inbred wky rats

Summary

Summary: A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).

Top Publications

  1. ncbi Catecholamine-related gene expression correlates with blood pressures in SHR
    Valin Reja
    Hypertension and Stroke Research Laboratories, Department of Physiology, University of Sydney, Sydney, Australia
    Hypertension 40:342-7. 2002
  2. ncbi Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
  3. ncbi A physiogenomic approach to study the regulation of blood pressure
    Timm H Westhoff
    Medizinische Klinik IV, Nephrology, Charite, Campus Benamin Franklin, Berlin, Germany
    Physiol Genomics 23:46-53. 2005
  4. pmc Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels
    Kenichi Goto
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    J Physiol 561:215-31. 2004
  5. ncbi Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression
    He Wang
    Human Biomarker Center, Translational Medicine and Technology, GlaxoSmithKline, USA
    Biochem Biophys Res Commun 315:363-8. 2004
  6. ncbi Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
  7. ncbi Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
    Dario Leosco
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 293:H1596-603. 2007
  8. ncbi Cellular aspects of vascular remodeling in hypertension revealed by confocal microscopy
    S M Arribas
    Clinical Research Initiative in Heart Failure, Institute of Biomedical and Life Sciences, Western Infirmary, University of Glasgow, UK
    Hypertension 30:1455-64. 1997
  9. ncbi Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats
    Joseph Friedman
    A J Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Hashomer, Israel
    Am J Hypertens 16:1049-52. 2003
  10. ncbi Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas, Maracaibo, Venezuela
    J Pharmacol Exp Ther 315:51-7. 2005

Research Grants

  1. Rodent Model of PTSD-like conditions-Role of Noradrenergic System
    SHANAZ MOHAMMEDALI TEJANI BUTT; Fiscal Year: 2010
  2. Kevin C H Pang; Fiscal Year: 2016
  3. David A Morilak; Fiscal Year: 2016
  4. Nicotine, Neurotrophins and Depression
    Yousef Tizabi; Fiscal Year: 2009
  5. YAHUAN LOU; Fiscal Year: 2015
  6. Hongyu Qiu; Fiscal Year: 2016
  7. Neural mechanisms of extinction-resistant avoidance behavior
    Kevin D Beck; Fiscal Year: 2013
  8. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
  9. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
  10. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 1999

Detail Information

Publications279 found, 100 shown here

  1. ncbi Catecholamine-related gene expression correlates with blood pressures in SHR
    Valin Reja
    Hypertension and Stroke Research Laboratories, Department of Physiology, University of Sydney, Sydney, Australia
    Hypertension 40:342-7. 2002
    ..Clearly, a decrease in central alpha2A-R and an increase in alpha1A-R is consistent with the elevated blood pressure and sympathetic activity observed in SHR...
  2. ncbi Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
    ..Therefore, beta2ARs play a critical role in endothelial cell proliferation and function including revascularization, suggesting a novel and physiologically relevant role in neoangiogenesis in response to ischemia...
  3. ncbi A physiogenomic approach to study the regulation of blood pressure
    Timm H Westhoff
    Medizinische Klinik IV, Nephrology, Charite, Campus Benamin Franklin, Berlin, Germany
    Physiol Genomics 23:46-53. 2005
    ..The present physiogenomic approach is capable of detecting vasoregulatory mechanisms and may provide deeper insight into the genetics and physiology of blood pressure regulation...
  4. pmc Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels
    Kenichi Goto
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    J Physiol 561:215-31. 2004
    ....
  5. ncbi Impaired angiogenesis in SHR is associated with decreased KDR and MT1-MMP expression
    He Wang
    Human Biomarker Center, Translational Medicine and Technology, GlaxoSmithKline, USA
    Biochem Biophys Res Commun 315:363-8. 2004
    ..Our results indicate down-regulated KDR and MT1-MMP expression is associated with an impaired angiogenesis in SHRs. VEGF gene transfer is effective in ameliorating the impaired angiogenesis in SHRs...
  6. ncbi Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
    ..We conclude that artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter may provide a novel approach for correcting peripheral sympathetic hyperactivity in hypertension...
  7. ncbi Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
    Dario Leosco
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 293:H1596-603. 2007
    ..In conclusion, we demonstrate for the first time that exercise and beta-AR blockade can similarly ameliorate beta-AR signaling in the aged heart, leading to improved beta-AR responsiveness and corresponding LV inotropic reserve...
  8. ncbi Cellular aspects of vascular remodeling in hypertension revealed by confocal microscopy
    S M Arribas
    Clinical Research Initiative in Heart Failure, Institute of Biomedical and Life Sciences, Western Infirmary, University of Glasgow, UK
    Hypertension 30:1455-64. 1997
    ....
  9. ncbi Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats
    Joseph Friedman
    A J Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Hashomer, Israel
    Am J Hypertens 16:1049-52. 2003
    ..Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases...
  10. ncbi Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas, Maracaibo, Venezuela
    J Pharmacol Exp Ther 315:51-7. 2005
    ..Results suggest that NF-kappaB-driven intrarenal inflammatory reactivity play a major role in the pathogenesis of hypertension in the SHR...
  11. ncbi Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006
    ..Decreased calcium current after cardiac nNOS gene transfer contributes to the normalization of beta-adrenergic hyperresponsiveness in the SAN from hypertensive rats by modulating cyclic nucleotide signaling...
  12. pmc The role of particulate matter-associated zinc in cardiac injury in rats
    Urmila P Kodavanti
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27710, USA
    Environ Health Perspect 116:13-20. 2008
    ..Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air...
  13. ncbi Decreased endothelial size and connexin expression in rat caudal arteries during hypertension
    Nicole M Rummery
    Autonomic Synapse Group, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Hypertens 20:247-53. 2002
    ..Hypertension is accompanied by endothelial dysfunction. The present study has investigated endothelial cell morphology and connexin expression in the caudal artery of the rat during the development of hypertension...
  14. doi Subchronic inhalation of zinc sulfate induces cardiac changes in healthy rats
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 232:69-77. 2008
    ..These data indicate that inhalation of zinc at environmentally relevant levels induces cardiac effects. While changes are small in healthy rats, these may be especially relevant in individuals with pre-existent cardiovascular disease...
  15. ncbi Quantitative trait loci in genetically hypertensive rats. Possible sex specificity
    J S Clark
    Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland
    Hypertension 28:898-906. 1996
    ..1). The sex specificity of blood pressure quantitative trait loci will be important in designing congenic strains and substrains for fine genetic mapping and for identifying genes that regulate blood pressure...
  16. pmc New target regions for human hypertension via comparative genomics
    M Stoll
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 10:473-82. 2000
    ....
  17. ncbi Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki shi, Japan
    J Hypertens 19:1769-73. 2001
    ..These findings suggest that peripheral systemic injection of TH AS ODN may be effective as hypotensive therapy in SHR...
  18. ncbi Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway
    Loren E Wold
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Hypertension 39:69-74. 2002
    ..These data indicate that the leptin-induced cardiac contractile response is abolished by spontaneous hypertension, possibly because of mechanisms involving altered JAK/STAT, MAP kinase signaling, and NO response...
  19. ncbi Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection
    M Azizul Haque
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 169:1542-9. 2002
    ....
  20. ncbi Structure, function, and endothelium-derived hyperpolarizing factor in the caudal artery of the SHR and WKY rat
    Shaun L Sandow
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    Arterioscler Thromb Vasc Biol 23:822-8. 2003
    ..To quantify structural and functional characteristics of the caudal artery from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats with particular reference to endothelium-derived hyperpolarizing factor (EDHF)...
  21. ncbi Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants
    C C Will
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Psychiatry 8:925-32. 2003
    ....
  22. ncbi Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats
    Simona Racasan
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    Hypertension 44:83-8. 2004
    ..This suggests a critical role for perinatal pro- and antioxidant balance in programming BP later in life...
  23. ncbi Two different putative genetic animal models of childhood depression
    Oz Malkesman
    Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Ramat Gan
    Biol Psychiatry 59:17-23. 2006
    ..In an attempt to model childhood depression, we examined whether existing genetic animal models of depression in adult rats are also valid in prepubertal rats...
  24. ncbi Rat survival to anthrax lethal toxin is likely controlled by a single gene
    S H Nye
    PhysioGenix Inc, 10437 Innovation Drive, Milwaukee, WI 53226, USA
    Pharmacogenomics J 8:16-22. 2008
    ..We conclude that a rat test population can detect strain differences in response to anthrax lethal toxin. Survival is influenced by the host genome background and is likely due to a single gene with a recessive mode of inheritance...
  25. ncbi Cardiopulmonary responses of Wistar Kyoto, spontaneously hypertensive, and stroke-prone spontaneously hypertensive rats to particulate matter (PM) exposure
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
    J Toxicol Environ Health A 70:1912-22. 2007
    ..Preexisting cardiovascular disease may influence susceptibility to PM pulmonary and cardiac health effects in a disease-specific manner...
  26. ncbi Reduction of NO- and EDHF-mediated vasodilatation in hypertension: role of asymmetric dimethylarginine
    Jie Li
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China
    Clin Exp Hypertens 29:489-501. 2007
    ....
  27. ncbi Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats
    Li Sun
    Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Chin Med J (Engl) 121:2305-11. 2008
    ..The aim of this study was to evaluate PPAR isoforms expression profile in important organs of spontaneously hypertensive rats (SHR) and to understand the modulation of endogenous PPAR isoforms under inflammatory condition...
  28. ncbi Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome
    D L Ely
    Department of Biology, University of Akron, Ohio 44325
    Hypertension 16:277-81. 1990
    ..The data strongly suggest that hypertension in the SHR has two primary components of equal magnitude, one consisting of a small number of autosomal loci with a second Y-linked component...
  29. ncbi Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats
    R M McCarron
    Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892
    Am J Physiol 267:H2491-7. 1994
    ..In summary, these findings indicate hypertension may enhance responsiveness of endothelium to factors that promote monocyte adhesion...
  30. ncbi Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus
    B Jeffs
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, UK
    Nat Genet 16:364-7. 1997
    ..We identified a highly significant QTL on rat chromosome 5 with a lod score of 16.6 which accounts for 67% of the total variance, co-localizes with the genes encoding atrial and brain natriuretic factor and is blood pressure independent...
  31. ncbi Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats
    N D Vaziri
    Division of Nephrology, Department of Medicine, University of California at Irvine, USA
    Hypertension 31:1248-54. 1998
    ..Thus, development of hypertension is not due to a primary impairment of NO production in SHR. On the contrary, NO production is increased in young SHR both before and after the onset of hypertension...
  32. ncbi Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways
    F Thevenod
    II Department of Physiology, University of Saarland, D 66421 Homburg, Germany
    FASEB J 13:1751-61. 1999
    ..Degradation of oxidatively damaged Na+/K(+)-ATPase may contribute to the 'Fanconi syndrome'-like Na(+)-dependent transport defects associated with Cd-nephrotoxicity...
  33. ncbi Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain
    S M MacKenzie
    MRC Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK
    J Mol Endocrinol 24:321-8. 2000
    ..This is the first direct evidence that steroid hydroxylases involved in the final stages of corticosteroid biosynthesis are present in specific regions of the central nervous system...
  34. ncbi Leptin induces direct vasodilation through distinct endothelial mechanisms
    G Lembo
    Instituto di Ricovero e Cura a Carattere Scientifico, Neuromed, Pozzilli, Italy
    Diabetes 49:293-7. 2000
    ..Finally, the inhibition of nitric oxide synthase by NG-nitro-L-arginine-methyl ester does not modify blood pressure response to leptin, suggesting a predominant role of the EDHF mechanism in the hypotensive effect of leptin...
  35. ncbi Location of resistance arteries
    K L Christensen
    Department of Pharmacology, University of Aarhus, Denmark
    J Vasc Res 38:1-12. 2001
    ..Furthermore, evidence concerning man is not available. We therefore conclude the review with suggestions for future research in this area...
  36. ncbi p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 37:574-80. 2001
    ..These results indicate differential roles of ERK1/2 and p38 MAP kinase in AT(1)-stimulated VSMC growth and collagen production, which may contribute to vascular remodeling in hypertension...
  37. ncbi Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D 17495 Karlsburg, Germany
    J Hypertens 20:131-8. 2002
    ..In addition, the effect of differential genetic predisposition to hypertension of recipients of an SHR kidney on the development of post-transplantation hypertension was studied...
  38. ncbi The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia?
    Maurizio Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino 5, 62032, Camerino, Italy
    Mech Ageing Dev 123:547-59. 2002
    ..The occurrence in the hippocampus of SHR of regressive changes and astroglial reaction similar to those occurring in neurodegenerative disorders with cognitive impairment suggests that they represent an animal model of vascular dementia...
  39. ncbi Noradrenergic content and turnover rate in kidney and heart shows gender and strain differences
    Ann Caplea
    Department of Biology, The University of Akron, Akron, Ohio 44325 3908, USA
    J Appl Physiol 92:567-71. 2002
    ..This study suggests both a strain and gender difference in sympathetic nervous system activity through noradrenergic neurotransmission...
  40. ncbi Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH
    Paul R Saunders
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Dig Dis Sci 47:208-15. 2002
    ..We speculate that a stress-induced barrier defect may allow uptake of immunogenic substances into the colonic mucosa, initiating or exacerbating intestinal inflammation...
  41. ncbi The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes
    Lilia A Silveira
    Renal Pathophysiology Laboratory, Nephrology Unit, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Diabetes 51:1529-34. 2002
    ..The decreased glomerular cell proliferation in prehypertensive diabetic SHR is at least partly mediated by a higher expression of the Cdk inhibitor p27(Kip1)...
  42. ncbi Alfa 1 adrenergic potentiation of progesterone accumulation stimulated by vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in cultured rat granulosa cells
    Elzbieta Wasilewska-Dziubinska
    Department of Clinical Neuroendocrinology Medical Centre of Postgraduate Education, 04 158 Warsaw, Poland
    Neuro Endocrinol Lett 23:141-8. 2002
    ..These effects were markedly potentiated by alpha(1) adrenergic receptor stimulation...
  43. ncbi Estradiol increases salt intake in female normotensive and hypertensive rats
    Eric Kensicki
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    J Appl Physiol 93:479-83. 2002
    ..In conclusion, E2 was positively correlated with sodium intake in both strains of rat, with the hypertensive rats consuming more sodium than the normotensive rats...
  44. ncbi Difference of gene expression profiles in spontaneous hypertensive rats and Wistar-Kyoto rats from two sources
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 296:537-43. 2002
    ..Our study showed the complex nature of the genetic heterogeneity between SHR and WKY from different sources...
  45. ncbi Pulmonary and systemic effects of zinc-containing emission particles in three rat strains: multiple exposure scenarios
    Urmila P Kodavanti
    Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 70:73-85. 2002
    ..Inhalation exposures may result in particle accumulation and macrophage recruitment with potential strain differences in EPM clearance...
  46. ncbi Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats
    Urmila P Kodavanti
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 65:1545-69. 2002
    ..This evidence is consistent with greater cardiovascular events during acute PM episodes in compromised humans...
  47. ncbi Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat
    Urmila P Kodavanti
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:237-45. 2003
    ..These findings provide supportive evidence for the epidemiological associations of cardiovascular morbidity and ambient PM...
  48. ncbi A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats
    Kylie A Scoggan
    Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, Ontario, Canada
    J Lipid Res 44:911-6. 2003
    ..The identification of this naturally occurring mutation confirms that these rat strains are important animal models of sitosterolemia in which to study the mechanisms of sterol trafficking...
  49. ncbi Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities
    Sibel Ulker
    Department of Medicine, Institute of Clinical Science Block B, Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Hypertension 41:534-9. 2003
    ....
  50. ncbi Microarray analysis of rat chromosome 2 congenic strains
    Martin W McBride
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, Scotland
    Hypertension 41:847-53. 2003
    ..8 x 10(-3); P=0.0034) and WKY 4.03 x 10(-3)+/-5.1 x 10(-4); (95% CI -5.4 x 10(-3) to -8.9 x 10(-4); P=0.027). We also identified regions of conserved synteny, each containing the Gstm2 gene, on mouse chromosome 3 and human chromosome 1...
  51. ncbi Changes in autonomic activity and baroreflex sensitivity with the hypertension process and age in rats
    Ryuji Nagai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Pharmacol Physiol 30:419-25. 2003
    ..Therefore, the contribution of autonomic activity to hypertension may be discussed separately as a developmental period and a sustained period...
  52. ncbi Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II
    Ping Ye
    Medical Research Council Blood Pressure Group, Western Infirmary, Glasgow, Scotland G11 6NT, United Kingdom
    Endocrinology 144:3321-8. 2003
    ..To summarize, we have identified a local CYP11B2 response to sodium depletion in the hippocampus and cerebellum. This is the first such regulation of CYP11B2 transcription to be identified in the CNS...
  53. ncbi Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts
    Teruaki Mizobuchi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 171:1140-7. 2003
    ..Collectively, these data show that the Tregs that mediate col(V)-induced tolerance to lung allografts do not express SMAD7 and, therefore, are permissive to TGF-beta-mediated signaling...
  54. ncbi Immunity and beta-endorphin concentrations in hypothalamus and plasma in rats with steroid-induced polycystic ovaries: effect of low-frequency electroacupuncture
    Elisabet Stener-Victorin
    Department of Physiology, Götenborg University, Götenborg, Germany
    Biol Reprod 70:329-33. 2004
    ..In conclusion, these findings show that both the beta-endorphinergic and the immune system are significantly impaired in rats with steroid-induced PCO and that repeated EA treatments can restore some of these disturbances...
  55. pmc Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery
    Shaun L Sandow
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Physiol 556:875-86. 2004
    ..Furthermore, the data show for the first time that this developmentally regulated EDHF is dependent on direct electrotonic coupling via MEGJs...
  56. ncbi AKT participates in endothelial dysfunction in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, University of Naples Federico II, Italy
    Circulation 109:2587-93. 2004
    ..It was recently reported that AKT phosphorylates and activates endothelial nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction...
  57. ncbi Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs
    M Semmler
    GSF National Research Center, Institute for Inhalation Biology, Neuherberg Munich, Germany
    Inhal Toxicol 16:453-9. 2004
    ..1983) and Bailey et al. (1985)...
  58. ncbi Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter
    Peter S Gilmour
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, USA
    Inhal Toxicol 16:5-18. 2004
    ..Thus, one of the mechanisms for greater susceptibility of SH rats to PM exposure may involve an increased activation of the TLR4 signaling pathway...
  59. ncbi A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression
    Richard De La Garza
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Forchheimer Building Room 111, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Brain Res 1021:209-18. 2004
    ....
  60. ncbi Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    J Hypertens 22:2025-33. 2004
    ..e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)] in the kidney of SHR fed a regular or an antioxidant-rich diet...
  61. ncbi Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Br J Nutr 92:411-7. 2004
    ..The present results suggest that low-dose oral GABA has a hypotensive effect in SHR/Izm and that the hypotensive effect of FMG is due to GABA...
  62. ncbi Angiotensin-converting enzyme inhibition restores endothelial but not medial connexin expression in hypertensive rats
    Nicole M Rummery
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia
    J Hypertens 23:317-28. 2005
    ..The objective of this study was to determine whether similar changes are found in the aorta and whether effects in both aorta and caudal artery are present in the pre-hypertensive period or can be reversed by antihypertensive treatment...
  63. ncbi Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress
    Martin W McBride
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
    Hypertension 45:786-92. 2005
    ..Coupled to significant increases in nitrotyrosine levels in the kidney, this suggests a pathophysiological role of this protein in hypertension and oxidative stress. Similar processes may underlie oxidative stress in the vasculature...
  64. ncbi Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes
    Cruz A Hinojos
    Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Hypertension 45:698-704. 2005
    ..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression...
  65. ncbi Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries
    Luigi Manni
    Cardiovascular Institute and Wallenberg Laboratory, Sahlgrenska Academy, Goteborg University, Goteborg SE 413 45, Sweden
    Auton Neurosci 118:79-87. 2005
    ..Overall, our findings suggest that therapeutical approaches aimed at down-regulating the sympathetic tone to the ovary could be useful in the prevention and clinical treatment of PCOS...
  66. ncbi Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Together, our data highlight the complexity of hypertension and the numerous genes involved in and affected by this condition...
  67. ncbi Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls
    Lourdes A Fortepiani
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 289:R763-70. 2005
    ..Increasing oxidative stress elevated blood pressure further in SHR but not WKY. WKY are likely protected because of higher bioavailable levels of NO and the ability to upregulate catalase and GPx...
  68. ncbi Corticotropin-releasing factor 1 receptor-mediated mechanisms inhibit colonic hypersensitivity in rats
    B Greenwood-Van Meerveld
    Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neurogastroenterol Motil 17:415-22. 2005
    ..Our findings suggest that CRF1 receptor antagonism may represent a novel therapeutic approach for the treatment of IBS...
  69. pmc Effect of electro-acupuncture on ovarian expression of alpha (1)- and beta (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries
    Luigi Manni
    Cardiovascular Institute and Wallenberg Laboratory, Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    Reprod Biol Endocrinol 3:21. 2005
    ..Low-frequency (2 Hz) electro-acupuncture (EA) has been shown to modulate sympathetic markers as well as ovarian blood flow as a reflex response via the ovarian sympathetic nerves, in rats with EV-induced PCO...
  70. ncbi Cardiovascular and blood coagulative effects of pulmonary zinc exposure
    Peter S Gilmour
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 211:41-52. 2006
    ..These data suggest that cardiovascular blood coagulation impairments are likely following pulmonary zinc exposure and associated pulmonary injury and inflammation...
  71. pmc Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells
    Marianne Geiser
    Institute for Anatomy, University of Bern, Bern, Switzerland
    Environ Health Perspect 113:1555-60. 2005
    ..Particles within cells are not membrane bound and hence have direct access to intracellular proteins, organelles, and DNA, which may greatly enhance their toxic potential...
  72. pmc Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical properties
    Urmila P Kodavanti
    Pulmonary Toxicology Branch, Experimental Toxicology Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 113:1561-8. 2005
    ..Biologic effects were evident in those six studies. These studies demonstrate a pattern of rat strain-specific pulmonary and systemic effects that are not linked to high mass but appear to be dependent on CAP chemical composition...
  73. ncbi Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects
    Buket Demirci
    Department of Medicine, Institute of Clinical Science Block B, Queen s University Belfast, Belfast, UK
    J Hypertens 23:2219-27. 2005
    ..To assess the blockade of the renin-angiotensin system (RAS) or blood pressure-lowering on cardiovascular functions in hypertensive and ageing animals...
  74. ncbi Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine
    Elena M V de Cavanagh
    Physical Chemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Helguera 2365, Buenos Aires 1417, Argentina
    Am J Physiol Regul Integr Comp Physiol 290:R1616-25. 2006
    ..The mitochondrial-antioxidant actions of losartan may be an additional or alternative way to explain some of the beneficial effects of AT1-receptor antagonists...
  75. ncbi Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats
    Hannelore Haase
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    FASEB J 20:865-73. 2006
    ..The positive inotropic effect of MLC-1 peptides occurred in the absence of a hypertrophic response. Thus, expression of N-terminal domains of MLC-1 represent a valuable tool for the treatment of the failing heart...
  76. ncbi Distribution pattern of inhaled ultrafine gold particles in the rat lung
    S Takenaka
    GSF Institute for Inhalation Biology, Neuherberg Munich, Germany
    Inhal Toxicol 18:733-40. 2006
    ..To a low degree, systemic particle translocation took place...
  77. ncbi Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone
    Maria Astin Nielsen
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, SE 431 83 Molndal, Sweden
    Scand J Gastroenterol 41:773-81. 2006
    ..The aim of this study was to compare the role of the vagal cholinergic and nitrergic pathways in the accommodation reflex in these rat strains...
  78. ncbi Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats
    Natalia de las Heras
    Department of Physiology, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    J Hypertens 25:629-38. 2007
    ..The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension...
  79. pmc Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats
    Daniel Ely
    Department of Biology, University of Akron, Akron, OH 44325, USA
    BMC Cardiovasc Disord 7:6. 2007
    ..A potential candidate for this Y chromosome hypertension locus is Sry, a gene that encodes a transcription factor that is responsible for testes development and the Sry protein may affect other target genes...
  80. ncbi Systemic translocation of particulate matter-associated metals following a single intratracheal instillation in rats
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 98:231-9. 2007
    ....
  81. ncbi Hypertension increases retinal inflammation in experimental diabetes: a possible mechanism for aggravation of diabetic retinopathy by hypertension
    Kamila C Silva
    Renal Pathophysiology Laboratory, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Curr Eye Res 32:533-41. 2007
    ..Aggravation of the inflammatory process may be involved in the mechanism by which essential hypertension exacerbates retinopathy in the presence of diabetes...
  82. ncbi Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC
    Michele Ciccarelli
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Cell Signal 19:1949-55. 2007
    ..We propose a novel signal transduction pathway for beta(2)AR stimulation trough G(alphai) and SRC, leading to activation of AKT...
  83. ncbi Arterial hypertension exacerbates oxidative stress in early diabetic retinopathy
    Camila C Pinto
    Renal Pathophysiology Laboratory, Department of Internal Medicine, Faculty of Medical Sciences FCM, State University of Campinas, Campinas, Sao Paulo, Brazil
    Free Radic Res 41:1151-8. 2007
    ..0001). Hypertension aggravates oxidative-induced cytotoxicity in diabetic retina due to increasing of superoxide production and impairment of antioxidative system...
  84. pmc Endothelial alpha1-adrenoceptors regulate neo-angiogenesis
    M Ciccarelli
    Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular Sciences, Federico II University of Naples, Naples, Italy
    Br J Pharmacol 153:936-46. 2008
    ..The presence of alpha(1)-adrenoceptors on the endothelium suggests that these receptors may participate in regenerative phenomena by regulating the responses of endothelial cells involved in neo-angiogenesis...
  85. ncbi Evaluation of baroreflex function in young spontaneously hypertensive rats
    Vitor E Valenti
    Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 92:205-15. 2009
    ..The literature describes contradictory data regarding the onset of the baroreflex reduction in spontaneously hypertensive rats...
  86. ncbi Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway
    Carmine Vecchione
    IRCCS Neuromed, Pozzilli Is, Italy
    Diabetes 51:168-73. 2002
    ..In conclusion, leptin induces NO production by activating a PI 3-kinase-independent Akt-eNOS phosphorylation pathway...
  87. ncbi Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: reversal by lifelong antioxidant supplementation
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    Kidney Int 65:219-27. 2004
    ..The study further sought to explore the effect of diet modification on renal tissue NAD(P)H oxidase and calcineurin abundance...
  88. ncbi Quinapril effects on resistance artery structure and function in hypertension
    Lufang Yang
    Smooth Muscle Research Programme and Department of Anaesthesia, McMaster University, Hamilton, ON, Canada, L8N 3Z5
    Naunyn Schmiedebergs Arch Pharmacol 370:444-51. 2004
    ..An increase in apoptotic process of medial smooth muscle cells is one of the mechanisms underlying the vascular structural improvement...
  89. ncbi Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation
    Henrik Ten Freyhaus
    Klinik III für Innere Medizin der Universität zu Köln, Germany
    Cardiovasc Res 71:331-41. 2006
    ..We characterized the effects of the novel Nox inhibitor VAS2870 on PDGF-dependent ROS liberation and cellular events in vascular smooth muscle cells (VSMC)...
  90. ncbi Characterisation of colonic accommodation in Wistar Kyoto rats with impaired gastric accommodation
    Vicente Martinez
    Department of Integrative Pharmacology Gastrointestinal Biology, AstraZeneca R and D, Mölndal SE 431 83, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 376:205-16. 2007
    ..In WKY rats, impaired accommodation of the smooth muscle might not be a widespread phenomenon along the GI tract but rather a local disturbance...
  91. pmc Prevention by blockade of angiotensin subtype1-receptors of the development of genetic hypertension but not its heritability
    P Madeddu
    Clinica Medica and Farmacologia, University of Sassari, Italy
    Br J Pharmacol 115:557-62. 1995
    ..Thus, heritability of the SHR's hypertensive trait is not affected by pharmacological manipulation of the cardiovascular phenotype...
  92. ncbi Antisense inhibition of thyrotropin-releasing hormone reduces arterial blood pressure in spontaneously hypertensive rats
    S I Garcia
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Hypertension 37:365-70. 2001
    ..To summarize, the central TRH system seems to be involved in the etiopathogenesis of hypertension in this model of essential hypertension...
  93. pmc Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats
    J Duarte
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Br J Pharmacol 133:117-24. 2001
    ..These effects were associated with a reduced oxidant status due to the antioxidant properties of the drug...
  94. ncbi Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat
    S El Bardai
    UFR Physiologie-Pharmacologie, , Fes, Maroc
    Clin Exp Hypertens 23:329-43. 2001
    ....
  95. ncbi Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?
    G Zalba
    Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, Pamplona, Spain
    Nephrol Dial Transplant 16:2-5. 2001
    ..This study was designed to test the hypothesis that increased O2(.-) production, more than diminished nitric oxide (NO) generation, plays a critical role in endothelial dysfunction present in spontaneously hypertensive rats (SHR)...
  96. ncbi Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats
    H Girouard
    Department of Physiology, Faculty of Medicine, , Succursale Centreville, , Canada
    J Hypertens 19:1369-77. 2001
    ....
  97. ncbi Intrarenal transport and vasoactive substances in hypertension
    P A Ortiz
    Division of Hypertension, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Hypertension 38:621-4. 2001
    ..However, important questions regarding humoral control of nephron transport and its implications in hypertension remain unanswered, and intensive research in these areas is required...
  98. ncbi alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats
    Linda F Hayward
    Cardiovascular Center and Department of Internal Medicine, University of Iowa and Research Service of the Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Am J Physiol Heart Circ Physiol 282:H2336-45. 2002
    ..The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered alpha(2)-adrenoreceptor mechanisms in SHR...
  99. ncbi Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats
    Sheila A Doggrell
    Cardiovascular Pharmacology Group, Faculty of Medicine and Health Science, The University of Auckland, New Zealand
    J Pharm Pharmacol 54:707-15. 2002
    ..However, as the positive inotropic effect is not observed with clinically relevant concentrations at a physiological rate in heart failure, dofetilide is unlikely to be useful as a positive inotrope in the treatment of heart failure...
  100. ncbi Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats
    Mitsuhide Naruse
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo, Japan
    Hypertension 40:28-33. 2002
    ..These results suggest that aldosterone breakthrough occurs during long-term AT1A therapy, mainly by an AT2-dependent mechanism. Residual aldosterone may attenuate the cardioprotective effects of AT1A...
  101. ncbi Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats
    Masayuki Ushiyama
    Laboratory of Medicine, School of Medicine, Toho University, 6 11 1 Omori Nishi, Ota ku, Tokyo 146 8541, Japan
    Heart Vessels 16:189-95. 2002
    ..The effect of CO in the regulation of blood pressure is augmented, resulting in increased expression of HO gene when the function and/or production of NO is impaired...

Research Grants75

  1. Rodent Model of PTSD-like conditions-Role of Noradrenergic System
    SHANAZ MOHAMMEDALI TEJANI BUTT; Fiscal Year: 2010
    ....
  2. Kevin C H Pang; Fiscal Year: 2016
    ....
  3. David A Morilak; Fiscal Year: 2016
    ..abstract_text> ..
  4. Nicotine, Neurotrophins and Depression
    Yousef Tizabi; Fiscal Year: 2009
    ..The findings may also facilitate the development and evaluation of novel antidepressants and/or compounds useful in smoking cessation. ..
  5. YAHUAN LOU; Fiscal Year: 2015
    ..Accomplishment of those aims will not only reveal a unique immune tolerance mechanism occurring in the target organ, but also provide a working model for development of cell-based immunotherapy for autoimmune GN. ..
  6. Hongyu Qiu; Fiscal Year: 2016
    ....
  7. Neural mechanisms of extinction-resistant avoidance behavior
    Kevin D Beck; Fiscal Year: 2013
    ..Counteracting the neurobiological processes sub-serving enhanced processing of threat and safety in the medial prefrontal cortex will reduce avoidance to tolerable levels. ..
  8. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
    ..The observed changes in hemodynamics, renal and sympatho-adrenal function may suggest more appropriate and effective therapeutic interventions...
  9. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
    ..Interactions between these factors will be studied; and comparisons made of the various neuronal populations (and their sensitivities) in the pregnant and non-pregnant SHR and WKY animals...
  10. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 1999
    ..The results provided from these studies should increase our knowledge of the mechanism of hormonal modulation of vascular tone in a clinically relevant tissue, the renal vascular bed and its role in the etiology of hypertension. ..
  11. ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSION
    RUSSELL MANKES; Fiscal Year: 1992
    ....
  12. MECHANISM OF DEPRESSIVE BEHAVIOR IN WISTAR-KYOTO RATS
    Shanaz Tejani Butt; Fiscal Year: 2001
    ..The information gained from this study could provide a better understanding of why a clinical response is observed in some populations of depressed patients, while a resistance in treatment response is seen in others. ..
  13. Pathogenesis of Exercise Pressor Reflex Dysfunction in Hypertension
    ANNA LEAL; Fiscal Year: 2009
    ....
  14. NEURONAL CALCIUM CURRENT ALTERATIONS IN HYPERTENSION
    STEPHEN IKEDA; Fiscal Year: 1993
    ..It is hoped that the proposed study will help fill this void in our understanding of the pathobiology of hypertension and provide a basis for the development of improved antihypertensive agents...
  15. SODIUM AND CALCIUM METABOLISM IN PREHYPERTENSIVE STATE
    Vito Campese; Fiscal Year: 1990
    ....
  16. REGULATION OF NA+ REABSORPTION IN RAT COLLECTING DUCT
    C Hawk; Fiscal Year: 1993
    ..This will indicate the fraction of he observed Na+ flux which occurs through an amiloride-sensitive, electrogenic pathway versus a putative electroneutral cotransport pathway or by free diffusion through the paracellular pathway...
  17. HYPERTENSION, CIRCUMVENTRICULAR ORGANS, NUTRIENTS
    DIANE HARTLE; Fiscal Year: 1990
    ..If a simple amino acid like glutamate can have this marked an effect on blood pressure in the SHR, many other blood-borne nutrients may be able to excite or inhibit CVO neurons...
  18. BRAIN PEPTIDE AND AMINE TRANSMITTERS IN NEW STRAINS
    EDITH HENDLEY; Fiscal Year: 1993
    ....
  19. ATRIAL PEPTIDES IN NORMAL AND HYPERTENSIVE PREGNANCY
    Marshall Lindheimer; Fiscal Year: 1990
    ..Finally, this response to the solicited RFA represents an extension of applicants' ongoing research interests that center on the kidney and volume homeostasis in pregnancy...
  20. Role of Cerebrovascular K+ Channels in Hypertension
    NANCY RUSCH; Fiscal Year: 2005
    ..abstract_text> ..
  21. INCREASED HYPOXIA SENSITIVITY IN HYPERTENSIVE
    ROBERT TALLITSCH; Fiscal Year: 1992
    ..P. injection of the membrane stabilizer chlorpromazine...
  22. MECHANISMS CONTRIBUTING TO HYPERTENSION
    Amy Milsted; Fiscal Year: 1999
    ....
  23. NEURAL ASPECTS OF IMMUNE DEFICIENCY
    Vincent Gattone; Fiscal Year: 1991
    ..The SHR model may prove to be valuable for both: a) understanding neurally induced immunodeficiency and b) testing drug efficacy for increasing immune function in the immune deficient subject (i.e. AIDS patients)...
  24. MICROVASCULAR NETWORK IN GROWTH & HYPERTENSION
    Thomas Skalak; Fiscal Year: 1992
    ..By applying this method to both WKY and SHIR, a test can be made of the hypothesis that the elevated resistance in spontaneous hypertension is an adaptation to changes in hemodynamic conditions, but is based on a common growth principle...
  25. GENETIC MAPPING IN THE HYPERCALCIURIC STONE-FORMING RAT
    STEVEN SCHEINMAN; Fiscal Year: 2003
    ..abstract_text> ..
  26. ENDOTHELIAL CONTROL OF THE PERIPHERAL CIRCULATION
    Richard Rivers; Fiscal Year: 1992
    ..Hypertension will be studied by comparing the endothelial function in the mesentaric arterioles of SHR and WKY rats using the techniques to be developed in phase I...
  27. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  28. SIGNALING PATHWAYS REGULATED BY MECHANICAL STRAIN IN VSM
    Raphael Nemenoff; Fiscal Year: 2002
    ..Specific Aim 3 will compare the effects of mechanical strain on aortic SMC isolated from SHR and WKY rats to determine if abnormal responses to strain mediate the altered growth properties of these cells. ..
  29. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  30. HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGES
    Robert Cox; Fiscal Year: 2007
    ..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..
  31. Effect of CRF1 Receptor Genotype and Stress on Anxiety and Alcohol Endophenotypes
    Lisa Conti; Fiscal Year: 2008
    ..The purpose of these studies is to examine the relationship between stress and different CRF genotypes on anxiety and alcohol use endophenotypes. [unreadable] [unreadable] [unreadable]..
  32. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  33. Metabolomics and metabolic compartmentation in the brain
    Julian Griffin; Fiscal Year: 2006
    ..To correlate NMR observable metabolite changes with transcriptional changes. Our data will provide proof-of principle for this methodology, and establish a means for exploring other neurolodegenerative disorders. ..
  34. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  35. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  36. Mechanisms of peripheral vascular anesthetic sensitivity
    THOMAS STEKIEL; Fiscal Year: 2008
    ..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
  37. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  38. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  39. Molecular fingerprints of alcohol-induced organ damage using new genetic models
    Steven Nye; Fiscal Year: 2008
    ..Relevance to public health: biomarkers will arm clinicians with the tools to predict individuals at risk for the effects of alcohol consumption and to track the progression of disease in patients. ..
  40. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  41. Linage and Segregation in Complex Genetic Diseases
    SUSAN HODGE; Fiscal Year: 2007
    ..The project will also be flexible and will move rapidly to address new and pressing problems as they arise during the grant period, as this investigator has done successfully in the past. ..
  42. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
  43. The Renin-Angiotensin II System in Cardiovascular Remodeling
    KATHLEEN BERECEK; Fiscal Year: 2007
    ..These studies will allow us to identify new targets for pharmacological intervention to prevent adverse cardiovascular remodeling in hypertension. ..
  44. ANATOMICAL STUDIES OF BRAINSTEM CARDIOVASCULAR SYSTEMS
    Sue Aicher; Fiscal Year: 2007
    ..This collaborative project provides a unique opportunity to directly address structural and physiological questions regarding NTS neuronal function in both the normal and hypertensive states. [unreadable] [unreadable]..
  45. Arteriogenesis by Ultrasonic Microbubble Destruction
    Richard J Price; Fiscal Year: 2010
    ..Given the broad applicability of this targeted gene delivery method, it is likely these studies will have a significant impact on the investigation and treatment of many other pathologies and conditions. ..
  46. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. Development of an In-Vitro Angiogenesis System
    Thomas Neumann; Fiscal Year: 2006
    ..Moreover, the model has a significant potential to be translated into microvascular systems for artificial tissues and organs. We consider our research program to be ideally suited to the R21 mechanism. ..
  48. REGULATION OF AUTOIMMUNITY THROUGH EPITOPE SPREADING
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..This in turn would contribute to developing novel therapeutic approaches for RA and other autoimmune diseases. [unreadable] [unreadable]..
  49. Proteome Mapping of Heart Failure in Aging
    MARVIN BOLUYT; Fiscal Year: 2005
    ..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
  50. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ....
  51. ENDOTHELIAL CONTROL OF ARTERIOLAR TONE IN HYPERTENSION
    Akos Koller; Fiscal Year: 2004
    ....
  52. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  53. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..We also will assess the effect of NAT1 and NAT2 genotypes in breast cancer risk through participation in ongoing molecular epidemiology investigations of breast cancer in Shanghai China and in Nashville, Tennessee. ..
  54. Vascular Protection & Endothelin B Receptors in Diabetes
    Adviye Ergul; Fiscal Year: 2009
    ..abstract_text> ..
  55. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..
  56. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  57. NEPHRITOGENIC EPITOPES IN GOODPASTURES SYNDROME
    WARREN BOLTON; Fiscal Year: 2001
    ..Further, the knowledge resultant from these investigations may provide a basis for the eventual development of specific therapeutic interventions for Goodpasture's syndrome. ..
  58. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  59. Growth hormone secretagogue MK-677 therapy in CKD and ESRD
    WARREN BOLTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  61. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..A specific objective is to develop a method to separate passive from active transport properties of pericardium and diaphragm, tissues that have both mesothelium and interstitium. ..
  62. Modulation of Autoimmunity by Green Tea Polyphenols
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..The results of this study would help in establishing a reliable scientific basis for the use of PGT in autoimmune arthritis, and in developing better therapeutic approaches for RA. ..
  63. Sympathetic Outflow to Catecholamine Storage Vesicles
    DANIEL O CONNOR; Fiscal Year: 2006
    ..Finally, these photoprotein and cDNA reagents can be widely employed by other investigators in elucidating biosynthetic, trafficking, and ion flux events in the sympathochromaffin system. ..
  64. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. [unreadable] [unreadable] [unreadable]..
  65. Molecular Mechanism of Acupuncture
    Gabriela Garcia; Fiscal Year: 2006
    ..We believe that our studies may open new era towards molecular understanding of acupuncture treatment in pain, inflammation, as well as a variety of vascular diseases in humans. ..
  66. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  67. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2005
    ..abstract_text> ..
  68. Combinatorial rat panels that genetically screen anthrax
    Steven Nye; Fiscal Year: 2003
    ..Decoding these data will begin to define the genomic contribution of the host-pathogen relationship. The goal in this project is to validate a new panel of rats for detecting the genetic effects of anthrax LeTx. ..
  69. Mechanism of Endothelial Dysfunction in Diabetes
    Adviye Ergul; Fiscal Year: 2004
    ..The results will lead to the development of novel therapeutic targets for the high-risk diabetic patients and may identify subgroups of patients that would be more suitable for these new treatment strategies. ..
  70. Effect Of Stress On Vascular NOS In Aged
    LESLIE FUCHS; Fiscal Year: 2004
    ..These studies may lead to better treatment of the cardiovascular diseases associated with behavioral stress. ..
  71. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..
  72. BRAIN AND CARDIAC ANGIOTENSIN II IN HYPERTENSION
    KATHLEEN BERECEK; Fiscal Year: 2003
    ..These studies are highly novel and could help to define new strategies not only for the treamtent of hypertension but its prevention as well. ..