inbred hrs mice

Summary

Summary: Homozygous, permanently near-hairless mice which lose their hair at about 10 days of age.

Top Publications

  1. ncbi Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen
    Sitarina Widyarini
    Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    Photochem Photobiol 81:32-7. 2005
  2. ncbi Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection
    Catherine S Tripp
    Department of Arthritis and Inflammation Pharmacology, Pharmacia Corporation, St Louis, Missouri, USA
    J Invest Dermatol 121:853-61. 2003
  3. ncbi Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin
    H J Kim
    Department of Dermato Immunology, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul, South Korea 137 040
    Apoptosis 9:449-56. 2004
  4. ncbi Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen
    Scott C Wasdo
    Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA
    Pharm Res 21:940-6. 2004
  5. ncbi Influence of hydroxypropyl-beta-cyclodextrin on the transdermal permeation and skin accumulation of oxybenzone
    Linda A Felton
    University of New Mexico, Health Sciences Center, College of Pharmacy, 2502 Marble NE, Albuquerque, NM 87131, USA
    Drug Dev Ind Pharm 28:1117-24. 2002
  6. ncbi Topical tacrolimus in combination with simulated solar radiation does not enhance photocarcinogenesis in hairless mice
    Catharina M Lerche
    Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Exp Dermatol 17:57-62. 2008
  7. ncbi Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC
    Ronnie L Aycock
    Department of Biochemistry, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    J Invest Dermatol 123:592-9. 2004
  8. ncbi Inhibition of ultraviolet light-induced oxidative events in the skin and internal organs of hairless mice by isoflavone genistein
    Huachen Wei
    Department of Dermatology, Box 1047, Mount Sinai School of Medicine, One Gustave Levy Place, 1425 Madison Avenue, New York, NY 10029, USA
    Cancer Lett 185:21-9. 2002
  9. ncbi Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches
    Kathy P An
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 76:73-80. 2002
  10. ncbi In-vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS
    Adrian Peter Funke
    Pharmaceutical Development, Schering AG, 13342, Berlin, Germany
    J Control Release 82:63-70. 2002

Detail Information

Publications190 found, 100 shown here

  1. ncbi Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen
    Sitarina Widyarini
    Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    Photochem Photobiol 81:32-7. 2005
    ....
  2. ncbi Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection
    Catherine S Tripp
    Department of Arthritis and Inflammation Pharmacology, Pharmacia Corporation, St Louis, Missouri, USA
    J Invest Dermatol 121:853-61. 2003
    ..We hypothesize that selective COX-2 inhibition, as described herein, may lead to enhanced removal of ultraviolet-damaged keratinocytes, thereby decreasing malignant transformation in the epidermis...
  3. ncbi Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin
    H J Kim
    Department of Dermato Immunology, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul, South Korea 137 040
    Apoptosis 9:449-56. 2004
    ..These results suggest that the TAPS co-treatment synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2...
  4. ncbi Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen
    Scott C Wasdo
    Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA
    Pharm Res 21:940-6. 2004
    ....
  5. ncbi Influence of hydroxypropyl-beta-cyclodextrin on the transdermal permeation and skin accumulation of oxybenzone
    Linda A Felton
    University of New Mexico, Health Sciences Center, College of Pharmacy, 2502 Marble NE, Albuquerque, NM 87131, USA
    Drug Dev Ind Pharm 28:1117-24. 2002
    ..When the concentration of HPCD was increased to 20%, both transdermal permeation and skin accumulation decreased. These data suggest the formation of a drug reservoir on the surface of the skin...
  6. ncbi Topical tacrolimus in combination with simulated solar radiation does not enhance photocarcinogenesis in hairless mice
    Catharina M Lerche
    Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Exp Dermatol 17:57-62. 2008
    ..363). We conclude that tacrolimus ointment does not accelerate photocarcinogenesis or induce any dermal carcinogenicity in hairless mice...
  7. ncbi Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC
    Ronnie L Aycock
    Department of Biochemistry, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    J Invest Dermatol 123:592-9. 2004
    ..In conclusion, SPARC appears to have a crucial role in mediating tumor formation in response to UV irradiation...
  8. ncbi Inhibition of ultraviolet light-induced oxidative events in the skin and internal organs of hairless mice by isoflavone genistein
    Huachen Wei
    Department of Dermatology, Box 1047, Mount Sinai School of Medicine, One Gustave Levy Place, 1425 Madison Avenue, New York, NY 10029, USA
    Cancer Lett 185:21-9. 2002
    ..Thus, the antioxidative properties of genistein may explain for the mechanisms of anti-photocarcinogenic action of genistein...
  9. ncbi Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches
    Kathy P An
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 76:73-80. 2002
    ..In summary, enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC. These results suggest that COX-2 inhibitors could have potent anticarcinogenic effects in UVB-induced skin cancer...
  10. ncbi In-vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS
    Adrian Peter Funke
    Pharmaceutical Development, Schering AG, 13342, Berlin, Germany
    J Control Release 82:63-70. 2002
    ....
  11. ncbi Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors
    Alice P Pentland
    Departments of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cancer Res 64:5587-91. 2004
    ..The lack of protection observed here confirms cancer mechanisms are distinct in UV- and tumor promotor-induced cancer models and indicates that chemoprevention strategies must specifically address cancer causes to be effective...
  12. ncbi Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling
    Gu Mallikarjuna
    Department of Pharmaceutical Sciences, School of Pharmacy, and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cancer Res 64:6349-56. 2004
    ..Furthermore, these results also identify in vivo molecular mechanisms of silibinin efficacy against photocarcinogenesis...
  13. ncbi Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester
    Petras Juzenas
    Division of Dermatology, Notre Dame Hospital, Montreal University Hospital Center, 1560 Sherbrooke Street East, Rm K 5201, Quebec, H2L 4M1, Montreal, Canada
    J Photochem Photobiol B 67:11-7. 2002
    ..In conclusion, the highest tumour to normal skin PpIX ratio was observed 3 h after application of 8% ALA-Me, suggesting that light exposure should be performed at this time in order to achieve an optimal PDT effect in this tumour model...
  14. ncbi Ergocalciferol promotes in vivo differentiation of keratinocytes and reduces photodamage caused by ultraviolet irradiation in hairless mice
    Hiroaki Mitani
    Kose Co Research and Development Division, 1 18 4 Azusawa, Itabashi ku, Tokyo, Japan
    Photodermatol Photoimmunol Photomed 20:215-23. 2004
    ..Ergocalciferol (VD(2)) is usually administered orally and it is metabolized to produce its biologically active metabolites in the liver and kidney. Active vitamin D is a well-known potent regulator of cell growth and differentiation...
  15. ncbi Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo
    R Blaudschun
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, 50934 Cologne, Germany
    Br J Dermatol 146:581-7. 2002
    ..Ultraviolet (UV)-B irradiation has been shown to be an inducer of vascular endothelial growth factor (VEGF) in primary keratinocytes and epidermal cell lines in vitro...
  16. ncbi Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA
    Eur J Cancer Prev 11:S28-36. 2002
    ..Using data from individual mice and linear regression analysis, we found a highly significant positive correlation between the thickness of the dermal fat layer away from tumors and the number of tumors per mouse...
  17. ncbi Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors
    Traci A Wilgus
    The Ohio State University, Department of Pathology, Columbus, Ohio, USA
    J Invest Dermatol 122:1488-94. 2004
    ....
  18. ncbi Exposure to soil contaminated with an environmental PCB/PCDD/PCDF mixture modulates ultraviolet radiation-induced non-melanoma skin carcinogenesis in the Crl:SKH1-hrBR hairless mouse
    Rhian B Cope
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4804, USA
    Cancer Lett 191:145-54. 2003
    ..Contaminant exposure was also associated with increased UV absorbance of skin methanol extracts implying a sunscreen-like effect...
  19. ncbi Effects of topical L-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice
    Karen E Burke
    Department of Biostatistics, University of Connecticut Health Center, Farmington, USA
    J Am Acad Dermatol 49:458-72. 2003
    ..The antioxidants selenium and vitamin E can be effective in reducing acute and chronic ultraviolet (UV)-induced skin damage...
  20. ncbi Influence of cyclodextrin complexation on the in vivo photoprotective effects of oxybenzone
    Linda A Felton
    Health Sciences Center, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Drug Dev Ind Pharm 30:95-102. 2004
    ..No single HPCD-containing sunscreen, however, was found to be equivalent to a commercially available sunscreen product for all biomarkers investigated...
  21. ncbi Chronic UVB exposure enhances in vitro percutaneous penetration of 5-aminulevulinic acid in hairless mouse skin
    Johanna T H M van den Akker
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, United Kingdom
    Lasers Surg Med 34:141-5. 2004
    ..This might be the result of a higher percutaneous penetration of ALA into (pre)cancerous skin...
  22. ncbi Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms
    Yen Kim Won
    Department of Community, Occupational, and Family Medicine, Faculty of Medicine, National University of Singapore, 16 Medical Drive, Singapore 117597, Republic of Singapore
    Carcinogenesis 25:1449-58. 2004
    ....
  23. ncbi Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis
    Sivanandhan Dhanalakshmi
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Carcinogenesis 25:1459-65. 2004
    ..Comparable effects of silibinin following its pre- or post-UV application suggest that mechanisms other than sunscreen effect are operational in silibinin efficacy against UV-caused skin damages...
  24. ncbi Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen
    Adrian Peter Funke
    Pharmaceutical Development, Schering AG, Berlin, Germany
    Drug Dev Ind Pharm 29:785-93. 2003
    ..06 microg cm(-2) h(-1). However, application of these TDSs on skin pretreated with permeation enhancers raised the fluxes to 2.6 microg cm(-2) h(-1) from Gelva/HPC and 0.46 microg cm(-2) h(-1) from fleece/Sekisui...
  25. pmc Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study
    Fredric J Burns
    Department of Environmental Medicine, School of Medicine, New York University, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Environ Health Perspect 112:599-603. 2004
    ....
  26. ncbi Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin
    Angela K Pannier
    Department of Biological Systems Engineering, University of Nebraska, Lincoln, NE 68583 0726, USA
    Int J Pharm 275:217-26. 2004
    ..The presence of G-quartets correlated with better PMO penetration from a water vehicle. Overall, the data suggest that some oligomers and vehicles would be better for transdermal delivery and others for topical applications...
  27. ncbi Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 121:362-7. 2003
    ..These results suggest that, like the nervous system, influx of calcium and chloride ions into epidermal keratinocytes through ionotropic receptors plays a crucial role in cutaneous barrier homeostasis...
  28. ncbi Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 24:1379-88. 2003
    ..Together, it can be suggested that inhibition of photocarcinogenesis by GSP treatment may be associated with the reduction in UVB-induced oxidative damage and tissue fat content...
  29. ncbi In vitro permeation study of hinokitiol: effects of vehicles and enhancers
    Hyang Hee Joo
    School of Biotechnology and Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, Kangwon Do, Korea
    Drug Deliv 15:19-22. 2008
    ..Each was added to the HKL solution (1%) so that the concentration of the enhancer was 1%. Among the enhancers, DP was the most effective and it enhanced the permeation of HKL approximately 5-10 times...
  30. ncbi Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
    ..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...
  31. doi Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice
    Shelley B Riedel
    Section of Molecular Genetics and Microbiology, The University of Texas, Austin, TX 78712, USA
    Anticancer Drugs 19:175-81. 2008
    ..In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits...
  32. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  33. ncbi Skin permeation, biodistribution, and expression of topically applied plasmid DNA
    Min Jeong Kang
    College of Pharmacy, Seoul National University, Seoul, South Korea
    J Gene Med 6:1238-46. 2004
    ..Topical application is emerging as a new route of gene delivery. However, the extent of skin permeation and the in vivo fate of topically applied plasmid DNA are not fully understood...
  34. ncbi Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice
    Heggert Rebel
    Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, Leiden, The Netherlands
    Carcinogenesis 26:2123-30. 2005
    ....
  35. ncbi Skin permeation of ketotifen applied from stick-type formulation
    Chiharu Kimura
    College of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan
    Eur J Pharm Biopharm 67:420-4. 2007
    ..The rate of skin permeation of KT was approximately proportional to the loading dose of the drug...
  36. ncbi Protection from photodamage by topical application of caffeine after ultraviolet irradiation
    S W Koo
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Br J Dermatol 156:957-64. 2007
    ..Topical caffeine application to mouse skin that had previously been treated with UV has been shown to inhibit the subsequent development of squamous cell carcinomas...
  37. ncbi Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development
    Vladislava O Melnikova
    Department of Immunology, The University of Texas MD Anderson Cancer Center, PO Box 301402, Unit 902, Houston, TX 77030, USA
    Oncogene 24:7055-63. 2005
    ....
  38. ncbi Depletion of CD4+ cells exacerbates the cutaneous response to acute and chronic UVB exposure
    Jennifer L Hatton
    Department of Pathology, The Ohio State University, Columbus, Ohio, USA
    J Invest Dermatol 127:1507-15. 2007
    ..Our findings suggest that CD4+ T cells play an important role in modulating both the acute inflammatory and the chronic carcinogenic response of the skin to UVB...
  39. ncbi Investigation of iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity
    Yifan Song
    Laboratory for Drug Delivery, Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, NJMS, 111 Lock Street, Newark, NJ 07103, USA
    Pharm Res 22:1918-25. 2005
    ..Very few chemical enhancers for transdermal drug delivery have been approved for clinical use due to irritancy and toxicity concerns. Novel chemical enhancers (iminosulfuranes) were synthesized and studied for their activity and toxicity...
  40. ncbi Using cyclodextrin complexation to enhance secondary photoprotection of topically applied ibuprofen
    Donald A Godwin
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Eur J Pharm Biopharm 62:85-93. 2006
    ..Edema and epidermal lipid damage data demonstrated that application of ibuprofen-HPCD formulations within 1h of UV exposure provided significant photoprotection...
  41. ncbi Effects of UVB on E prostanoid receptor expression in murine skin
    Kathleen L Tober
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    J Invest Dermatol 127:214-21. 2007
    ..Differential expression of the EP receptors suggests that each receptor may play a distinct role in skin tumor development...
  42. ncbi Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice
    Yao Ping Lu
    William M and Myrle W Garbe Professor of Cancer and Leukemia Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
    Carcinogenesis 28:199-206. 2007
    ..Our studies suggest that caffeine-SB and caffeine may be good agents for inhibiting the formation of sunlight-induced skin cancer...
  43. ncbi Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:412-7. 2006
    ..0, 3.0 MHz), intensity (1.0, 2.5 W/cm2), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode...
  44. ncbi The effect of sunscreen on skin elastase activity induced by ultraviolet-A irradiation
    Kazue Tsukahara
    Biological Science Laboratories, Kao Corporation, Ichikai, Haga, Japan
    Biol Pharm Bull 28:2302-7. 2005
    ..These results suggest the partial efficacy of the topical photoprotection from UVA by the sunscreen in inhibiting elastase activation, and also suggest the possibility of reducing photoaging...
  45. ncbi Chemical peeling by SA-PEG remodels photo-damaged skin: suppressing p53 expression and normalizing keratinocyte differentiation
    Teruki Dainichi
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Invest Dermatol 126:416-21. 2006
    ..These results suggest that the stratum corneum plays a protective role against carcinogenesis, and provide a novel strategy for the prevention of photo-induced skin tumors...
  46. ncbi Importance of the EP(1) receptor in cutaneous UVB-induced inflammation and tumor development
    Kathleen L Tober
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    J Invest Dermatol 126:205-11. 2006
    ..This study suggests that drugs designed to block EP(1) may have the potential to be used as anti-inflammatory and/or chemopreventive agents that reduce the risk of skin cancer development...
  47. ncbi Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression
    J Doig
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Oncogene 25:6229-38. 2006
    ..These responses are more pronounced than have been reported for other NER-deficient mice, demonstrating that Ercc1 has a key role in protecting against UV-induced skin cancer...
  48. ncbi [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
    Jin Kyoung Kim
    Department of Dermato Immunology, College of Medicine, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea
    Free Radic Res 41:603-14. 2007
    ..These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders...
  49. ncbi Influence of Transcutol CG on the skin accumulation and transdermal permeation of ultraviolet absorbers
    Donald A Godwin
    University of New Mexico Health Sciences Center, College of Pharmacy, 2502 Marble NE, Albuquerque, NM 87131, USA
    Eur J Pharm Biopharm 53:23-7. 2002
    ..The results of this study demonstrate that the inclusion of Transcutol CG in sunscreen formulations increases the skin accumulation of the UV absorbers oxybenzone and cinnamate without a concomitant increase in transdermal permeation...
  50. ncbi Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice
    Pavel Kramata
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 65:3577-85. 2005
    ....
  51. ncbi The formation of wrinkles caused by transition of keratin intermediate filaments after repetitive UVB exposure
    Tomohiko Sano
    Skin Care Research Laboratories, Kao Corporation, 2 1 3 Bunka Sumidaku, 131 8501, Tokyo, Japan
    Arch Dermatol Res 296:359-65. 2005
    ..We conclude that the deterioration of KIFs in the stratum corneum caused by repetitive UVB irradiation decreases the elastic properties of the stratum corneum, resulting in the formation of wrinkles...
  52. ncbi An accumulation of glucosylceramide in the stratum corneum due to attenuated activity of beta-glucocerebrosidase is associated with the early phase of UVB-induced alteration in cutaneous barrier function
    Yutaka Takagi
    Kao Biological Science Laboratories, 2606 Akabane, Ichikai machi, Haga, Tochigi 321 3497, Japan
    Arch Dermatol Res 297:18-25. 2005
    ....
  53. ncbi Development of topical functionalized formulations added with propolis extract: stability, cutaneous absorption and in vivo studies
    F Marquele-Oliveira
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto USP, Av do Cafe S N, 14049 903 Ribeirao Preto, SP, Brazil
    Int J Pharm 342:40-8. 2007
    ....
  54. ncbi Multiple large-surface photodynamic therapy sessions with topical or systemic aminolevulinic acid and blue light in UV-exposed hairless mice
    Younan Liu
    Division of Dermatology, University of Montreal Hospital Centre, Montreal, Quebec, Canada
    J Cutan Med Surg 8:131-9. 2004
    ..The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses...
  55. ncbi Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha
    Suk Won Lim
    R and D Center for Skin Science and Cosmetics, ENPRANI, Inchon, Korea
    J Dermatol 34:625-34. 2007
    ..Taken together, these results suggest that UA and ONA will be pertinent candidates for the improvement of epidermal permeability barrier function...
  56. ncbi More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine
    Ymke G L de Graaf
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 17:349-55. 2008
    ..011). UV-induced UDS in humans is dominated by repair of cyclobutane pyrimidine dimers, and these DNA lesions can lead to 'UV-signature' mutations in the P53 gene, giving rise to p53 patches...
  57. ncbi Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice
    Ahmed N Uddin
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 221:329-38. 2007
    ....
  58. ncbi Combined effects of iontophoretic and chemical enhancement on drug delivery. II. Transport across human and murine skin
    L M A Nolan
    School of Chemistry, Trinity College, Dublin 2, Ireland
    Int J Pharm 341:114-24. 2007
    ..The investigation also indicated that the barrier properties of the skin recover following the constant current iontophoresis in the presence of oleic or lauric acids...
  59. ncbi Comparison of the effects of commonly used wound agents on epithelialization and neovascularization
    D Kjolseth
    Division of Plastic and Reconstructive Surgery, University of Louisville, KY 40292
    J Am Coll Surg 179:305-12. 1994
    ..For this study, a new wound model was used in which direct visualization and quantification of wound epithelialization and neovascularization were carried out throughout the entire healing process...
  60. ncbi Fermentable metabolite of Zymomonas mobilis controls collagen reduction in photoaging skin by improving TGF-beta/Smad signaling suppression
    Hiroshi Tanaka
    Research Laboratories, Nippon Menard Cosmetic Co Ltd, 2 7 Torimi cho, Nishi ku, Nagoya 451 0071, Japan
    Arch Dermatol Res 300:S57-64. 2008
    ..mobilis. From this experimental data, it is suggested that FM of Z. mobilis is effective for suppression of wrinkle formation in photoaging skin by inhibition of type I procollagen synthesis reduction...
  61. ncbi Effect of barrier disruption by acetone treatment on the permeability of compounds with various lipophilicities: implications for the permeability of compromised skin
    J C Tsai
    Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Pharm Sci 90:1242-54. 2001
    ..The results imply the possibility of using both TEWL and drug lipophilicity to predict alterations in skin permeability and hence the dose adjustment of topically applied medication for patients with impaired skin barrier function...
  62. ncbi Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect
    D J Robinson
    Photodynamic Therapy and Optical Spectroscopy Research Program, Subdivision of Clinical Physics, Department of Radiation Oncology, Daniel den Hoed Cancer Centre, University Hospital Rotterdam, Rotterdam, The Netherlands
    Photochem Photobiol 72:794-802. 2000
    ..PpIX photoproducts are formed during illumination and subsequently photobleached. PpIX photoproducts do not dissipate in the 2 h dark interval between illuminations...
  63. doi Cutaneous challenge with chemical warfare agents in the SKH-1 hairless mouse. (I) Development of a model for screening studies in skin decontamination and protection
    F Dorandeu
    Département de toxicologie et risque chimique, Institut de Recherche Biomédicale des Armées, Centre de Recherches du Service de Sante des Armees, La Tronche, France
    Hum Exp Toxicol 30:470-90. 2011
    ..Long-term effects of SM burn were also evaluated. The model was then used in the companion paper (Taysse et al.(1))...
  64. ncbi HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity
    Jurgen Fuchs
    Department of Dermatology, Medical School, J W Goethe University, Frankfurt, Germany
    Free Radic Biol Med 34:330-6. 2003
    ..Hence it is concluded that vitamin E alone is not a determinant of individual photosensitivity in humans...
  65. ncbi Effects of retinoids on phorbol ester-stimulated epidermal DNA synthesis and hyperplasia in hairless mice
    G J Gendimenico
    Bristol Myers Co, Pharmaceutical Research and Development Division, Buffalo, New York 14213
    J Invest Dermatol 93:363-7. 1989
    ..The biologic significance of a temporary suppression of TPA-stimulated epidermal DNA synthesis by the retinoids and fluocinonide is not understood at this time...
  66. ncbi Effects of systemic indomethacin, meclizine, and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin
    I E Kochevar
    Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston 02114
    J Invest Dermatol 100:186-93. 1993
    ....
  67. ncbi Delivery of hydrocortisone from liposomal suspensions to the hairless mouse skin following topical application under non-occlusive and occlusive conditions
    M K Kim
    College of Pharmacy, Seoul National University, Korea
    J Microencapsul 15:21-9. 1998
    ....
  68. ncbi Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate
    Chun Xiao Sun
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 11:3167-78. 2002
    ..These results suggest that merlin growth suppression requires HRS expression and that the binding of merlin to HRS may facilitate its ability to function as a tumor suppressor...
  69. ncbi An experimental approach to study the binding properties of vitamin E (alpha-tocopherol) during hairless mouse skin permeation
    A R Lee
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Chem Pharm Bull (Tokyo) 49:659-63. 2001
    ..During skin permeation, vitamin E forms a very strong reservoir in the skin tissue and this amount of vitamin E, about 30%, exists as a bound-form with the lipid components of the stratum corneum...
  70. ncbi Quantitative alterations of hyaluronan and dermatan sulfate in the hairless mouse dorsal skin exposed to chronic UV irradiation
    I Koshiishi
    Faculty of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi, Inage, Chiba shi, Chiba 263 8522, Japan
    Biochim Biophys Acta 1428:327-33. 1999
    ..These findings indicate that the increases of glycosaminoglycan contents in the UV-irradiated skin are related to the accumulation of the extracellular matrix components in the lower dermis...
  71. doi A noninvasive method for assessing interior skin damage caused by chronological aging and photoaging based on near-infrared diffuse reflection spectroscopy
    Yuta Miyamae
    POLA Chemical Industries, Inc, Corporate Planning Department, 27 1 Takashimadai, Kanagawa ku, Yokohama 221 0833 Japan
    Appl Spectrosc 62:677-81. 2008
    ..NIR-DR spectroscopy and PCA may allow us to noninvasively assess the degree of photoaging and chronological aging as the degeneration of elasticity in collagen protein and the degradation of protein quantity, respectively...
  72. ncbi Feasibility of transdermal delivery of prochlorperazine
    Yasuko Obata
    Department of Pharmaceutics, Hoshi University, Tokyo, Japan
    Biol Pharm Bull 33:1454-7. 2010
    ..Thus, it was considered that PCPZ was delivered to brain via systemic circulation by the administration of PCPZ hydrogel...
  73. doi Transport behavior of hairless mouse skin during constant current DC iontophoresis, part 2: iontophoresis of nonionic molecules with cotransport of polystyrene sulfonate oligomers
    Mark R Liddell
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Pharm Sci 100:2816-25. 2011
    ..Compared with the baseline results, the calculated radii were found to have increased up to around twofold and the iontophoretic fluxes of the probe permeants increased by as much sixfold...
  74. ncbi Hairless mouse epidermal antioxidants and lipid peroxidation assessed by He-Ne laser
    Y G Kim
    Department of Biological Science, College of Natural Sciences, Chosun University, Kwangju, Korea
    Lasers Surg Med 27:420-6. 2000
    ..To evaluate the possibility of oxygen radical damage in the skin after He-Ne laser irradiation according to dose intensity and time...
  75. ncbi Effect of sodium dodecyl sulfate on iontophoresis of hydrocortisone across hairless mouse skin
    Y Wang
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA
    Pharm Dev Technol 5:533-42. 2000
    ..Further increase in SDS concentration decreased flux, suggesting that the transport of micellar-solubilized drug is retarded by anodal iontophoresis, possibly due to electrostatic attraction...
  76. ncbi Designing for topical delivery: prodrugs can make the difference
    Kenneth B Sloan
    Department of Medicinal Chemistry, P O Box 100485, University of Florida, Gainesville, Florida 32610, USA
    Med Res Rev 23:763-93. 2003
    ..34 log SAQ. Numerous recent examples are also given where more water-soluble members of homologous series of prodrugs give higher flux values from water vehicles in vitro through human skin than the more lipid soluble ones...
  77. doi Cutaneous challenge with chemical warfare agents in the SKH-1 hairless mouse (II): effects of some currently used skin decontaminants (RSDL and Fuller's earth) against liquid sulphur mustard and VX exposure
    L Taysse
    Centre d études du Bouchet Defense research center Vert Le Petit, France
    Hum Exp Toxicol 30:491-8. 2011
    ..Some of these observations are different from our previous results obtained in domestic swine and these changes are thus discussed in the perspective of using SKH-1 hairless mice for the initial in vivo screening of decontaminants...
  78. ncbi Synthesis and evaluation of N-acetylprolinate esters - novel skin penetration enhancers
    S N Tenjarla
    Department of Pharmaceutical Sciences, Southern School of Pharmacy, Mercer University, Atlanta, GA 30341, USA
    Int J Pharm 192:147-58. 1999
    ..The 18- carbon ester which has a cis-double bond in the alkyl side chain, also increased the flux significantly...
  79. doi Retinyl retinoate induces hyaluronan production and less irritation than other retinoids
    Jin Eun Kim
    R and D Center of Skin Science and Cosmetics, ENPRANI, Incheon, South Korea
    J Dermatol 37:448-54. 2010
    ..Taken together, we suggest that retinyl retinoate is more effective on hyaluronan production and less of an irritant than other retinoids...
  80. pmc Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin
    Neera V Gopee
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 111:37-48. 2009
    ..Future dermal risk assessments of nanoscale materials should consider key barrier aspects of skin and its overall physiologic integrity...
  81. ncbi In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins
    Patricia M B G Maia Campos
    Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Brazil
    Photochem Photobiol 82:683-8. 2006
    ....
  82. ncbi Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems
    Amnon C Sintov
    Department of Pharmacology and School of Pharmacy, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Int J Pharm 311:55-62. 2006
    ..However, this unusual phenomenon observed in non-freshly used porcine skin places a question mark on its relevancy for in vitro penetration studies involving aqueous vehicle systems...
  83. ncbi Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse
    H J Ruven
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands
    Cancer Res 53:1642-5. 1993
    ..The selective repair of active genes in the epidermis of mice resembles that of rodent cells in culture and shows the biological relevance of repair studies performed with cultured rodent cells in vitro...
  84. ncbi Codiffusion of propylene glycol and dimethyl isosorbide in hairless mouse skin
    E Squillante
    Department of Applied Pharmaceutics, University of Rhode Island, Kingston, RI 02881, USA
    Eur J Pharm Biopharm 46:265-71. 1998
    ..Over a 24-h test period a dose dependent response was observed for N, with 4.9-15.6 mg of N delivered from the lowest and highest doses, respectively, and the highest dose yielding zero-order flux of 146 (g/h per cm2)...
  85. doi Evaluation of salicylic acid fatty ester prodrugs for UV protection
    Jong Seob Im
    College of Pharmacy, Yeungnam University, Dae Dong, Gyongsan, South Korea
    Drug Dev Ind Pharm 37:841-8. 2011
    ..Thus, the palmitoyl oxysalicylate (C16SA) might be a potential candidate for UV protection due to its absence of skin permeation, smaller uptake in the lipid phase and relatively lower skin accumulation...
  86. ncbi Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
    Christian R Gomez
    Department of Cell Biology, Neurobiology and Anatomy, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA
    Crit Care Med 35:246-51. 2007
    ..The objective of this study was to analyze pulmonary inflammatory responses in young and aged mice after administration of lipopolysaccharide...
  87. ncbi [Evaluation of the permeability of corticosteroid in hairless mouse and hairless micropig skin from admixture of commercially available corticosteroid ointments and/or creams]
    Michiteru Ohtani
    Department of Hospital Pharmacy, Tokyo Postal Services Agency Hospital, 2 14 23, Fujimi, Chiyoda ku, Tokyo 102 8798, Japan
    Yakugaku Zasshi 122:589-94. 2002
    ....
  88. ncbi Evaluation of the effect of different fatty acids on the percutaneous absorption of metaproterenol sulfate
    B M Elyan
    Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
    J Pharm Sci 85:101-5. 1996
    ..The data indicated that lauric acid increased the diffusivity of MPS in the skin by forming a complex and by affecting its partition coefficient between the skin and the delivery system...
  89. ncbi In vitro transungual permeation of ciclopirox from a hydroxypropyl chitosan-based, water-soluble nail lacquer
    Daniela Monti
    Department of Bioorganic Chemistry and Biopharmaceutics, University of Pisa, Pisa, Italy
    Drug Dev Ind Pharm 31:11-7. 2005
    ..This effect might be tentatively attributed to a particular affinity of HPCH for the membrane, resulting in intimate contact and strong adhesion of the HPCH lacquer to the keratin substrate...
  90. ncbi New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice
    A Sintov
    Ben Gurion University of the Negev, The Institutes for Applied Research, PO Box 653, Beer Sheva, Israel
    Int J Pharm 194:125-34. 2000
    ..It is therefore suggested that this topical composition containing flutamide or finasteride may effectively result in regression of male-pattern baldness...
  91. ncbi Determination of the maximal tumor/normal skin ratio after HpD or m-THPC administration in hairless mouse (SKh-1) by fluorescence spectroscopy--a non-invasive method
    E Bossu
    Laboratoire d Hematologie, Physiologie et Biologie Cellulaire, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Henri Poincare Nancy I, France
    Anticancer Drugs 8:67-72. 1997
    ..Photodynamic therapy with the same doses of HpD and m-THPC used in this pharmacokinetic study must also be carried out to compare the toxicities of the two photosensitizers and to determine which is best for this type of tumor...
  92. ncbi Cyclodextrins as permeation enhancers: some theoretical evaluations and in vitro testing
    M Masson
    Department of Pharmacy, University of Iceland, Hofsvallagata 53, P O Box 7210, IS 107 Reykjavik, Iceland
    J Control Release 59:107-18. 1999
    ....
  93. ncbi Melanoma induction in a hairless mouse with short-term application of dimethylbenz[a]anthracene
    L H Kligman
    Department of Dermatology, University of Pennsylvania School of Medicine, 202 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Melanoma Res 11:319-24. 2001
    ..Metastases were present in lymph nodes and lungs. There was a marked similarity between this melanoma and its precursor lesions and those seen in an earlier, Weiser-Maple guinea pig model, which, in turn, resembled human melanoma...
  94. ncbi From actinic keratosis to squamous cell carcinoma
    Jean Paul Ortonne
    CHU Nice, Service de Dermatologie, Hôpital L Archet 2, BP 3079, 06202 Nice cedex, France
    Br J Dermatol 146:20-3. 2002
    ..The relative efficacy of UV wavelengths (action spectrum) that induce SCC has been determined using the hairless mouse as a model. The action spectrum has been extrapolated to humans skin and is recognised worldwide...
  95. ncbi Protoporphyrin IX fluorescence photobleaching during ALA-mediated photodynamic therapy of UVB-induced tumors in hairless mouse skin
    D J Robinson
    Department of Radiation Oncology, Clinical Physics, Daniel den Hoed Cancer Centre, University Hospital Rotterdam, The Netherlands
    Photochem Photobiol 69:61-70. 1999
    ..The same correlation could be made with the data obtained from UVB-induced tumor tissue using a single light exposure. However, there was no such correlation when fractionation schemes were employed upon the tumor tissue...
  96. ncbi Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect
    D J Robinson
    Centre for Photobiology and Photodynamic Therapy, Research School of Medicine, University of Leeds, UK
    Photochem Photobiol 67:140-9. 1998
    ..In the absence of oxygen, PpIX and its photoproducts are not photobleached. We present a method of calculating a therapeutic dose delivered during superficial PDT that demonstrates a strong correlation with PDT damage...
  97. ncbi Degenerative alterations of dermal collagen fiber bundles in photodamaged human skin and UV-irradiated hairless mouse skin: possible effect on decreasing skin mechanical properties and appearance of wrinkles
    Y Nishimori
    POLA Laboratories, POLA Chemical Industries Inc, Yokohama, Japan
    J Invest Dermatol 117:1458-63. 2001
    ..Furthermore, degeneration of DCFB as detected ultrastructurally may, by its effect on skin elasticity, result in an increase in the appearance of wrinkles...
  98. ncbi Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin
    D J Chatterjee
    College of Pharmacy, University of Michigan, Ann Arbor 48109, USA
    Pharm Res 14:1058-65. 1997
    ....
  99. doi A correlation of flux through a silicone membrane with flux through hairless mouse skin and human skin in vitro
    Scott C Wasdo
    Department of Medicinal Chemistry, University of Florida, P O Box 100485, Gainesville, FL 32610, USA
    Int J Pharm 373:62-7. 2009
    ....
  100. ncbi Effects of cryobiological variables on the survival of skin using a defined murine model
    J N Kearney
    Yorkshire Regional Tissue Bank, Pinderfields General Hospital, Wakefield, United Kingdom
    Cryobiology 27:164-70. 1990
    ..Dimethyl sulfoxide was a marginally better cryoprotectant overall, although this difference was not statistically significant...
  101. ncbi Gene expression of retinoic acid receptors and cellular retinoic acid-binding proteins in rhino and hairless mouse skin
    B C Beehler
    Dermatology Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Buffalo, New York 14213, USA
    Arch Dermatol Res 287:488-93. 1995
    ..The results also support these two animals as models for evaluating the therapeutic potential of retinoids...

Research Grants67

  1. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..The results of these studies are intended to provide the basic information required for the development of novel skin disorders. ..
  2. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  3. Transcription regulation in the hairless pathway
    Andrew Engelhard; Fiscal Year: 2007
    ..abstract_text> ..
  4. Rapid Transdermal Delivery of Opioid Pain Medications
    Alan Smith; Fiscal Year: 2002
    ..A small pilot clinical study will also be performed to determine the feasibility of delivering fentanyl with a commercially available transdermal patch in conjunction with the microporation system. ..
  5. Therapeutic immunosuppression, inflammation & skin cancer
    Tatiana Oberyszyn; Fiscal Year: 2009
    ..The studies in the present proposal will help to clarify the role of CD4* T cells in UVB induced inflammation as well as in the cutaneous carcinogenesis process. ..
  6. Elucidation of the hr-dependent pathway of hair growth
    Andrey Panteleyev; Fiscal Year: 2005
    ..Thus, the experiments outlined in this proposal are designed to dissect the cellular and molecular mechanisms of hair follicle catagen transformation using the hairless phenotype as an experimental model. ..
  7. Mitochondrial DNA Mutations in Keratinocyte Hyperplasia
    JAMES SLIGH; Fiscal Year: 2006
    ....
  8. Mitochondrial DNA Mutations in Keratinocyte Hyperplasia
    JAMES SLIGH; Fiscal Year: 2007
    ....
  9. Elucidation of the hr-dependent pathway of hair growth
    Andrey Panteleyev; Fiscal Year: 2003
    ..abstract_text> ..
  10. Quantitative Characterization of UV induced skin damage
    Elisabeth Papazoglou; Fiscal Year: 2007
    ..abstract_text> ..
  11. NATURE OF THE MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 1993
    ..These studies could lead to novel approaches to enhance transdermal drug delivery, potentially allowing whole new classes of formerly excluded compounds to access the internal environment...
  12. Mouse Models of Skin Cancer
    Susan Fischer; Fiscal Year: 2007
    ..3) Where indicated, models with multiple genetic alterations will be developed. ..
  13. Hypoxia signaling to checkpoint activation and apoptosis
    Wafik El Deiry; Fiscal Year: 2009
    ..The work may lead to new strategies for limiting tumor growth at its earliest stages. ..
  14. Cancer Chemoprevention by Pomegranate Fruit Extract
    Farrukh Afaq; Fiscal Year: 2006
    ..HEALTH RELEVANCE: This proposal intends to define a novel photochemo- preventive agent against skin cancer for its possible use in humans. ..
  15. CYCLOOXYGENASE AND PGE2 RECEPTOR FUNCTION IN SKIN CANCER
    Alice Pentland; Fiscal Year: 2004
    ..EP receptor effects on keratinocyte proliferation, apoptosis and differentiation will be studied as markers of cutaneous neoplasia. ..