- Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
Dev Cell 11:711-22. 2006
..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
- Defective B cell development and function in Btk-deficient mice
W N Khan
Howard Hughes Medical Institute, Childrens Hospital, Boston, Massachusetts 02115, USA
Immunity 3:283-99. 1995
..These results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development...
- Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria
Spencer D Polley
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Infect Immun 71:1833-42. 2003
..The results are important for design of a vaccine to induce protective antibodies, and they address hypotheses about repeat sequences in malaria antigens...
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
Immunity 10:387-98. 1999
..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
- The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in mice
Eric H Weening
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
Infect Immun 73:3358-66. 2005
..Collectively, these data show that six fimbrial operons (lpf, bcf, stb, stc, std, and sth) contribute to long-term intestinal carriage of S. enterica serotype Typhimurium in genetically resistant mice...
- Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus
Fatih M Uckun
Parker Hughes Center for Clinical Immunology, St Paul, MN 55113, USA
BMC Infect Dis 4:1. 2004
- Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose
Pamela K Kreeger
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
Biol Reprod 73:942-50. 2005
..The culture system can be adapted to each stage of development, which will be especially critical for translation to human follicles that have a longer developmental period...
- TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
J J Peschon
Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
J Immunol 160:943-52. 1998
..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
- Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice
Howard Florey Institute, University of Melbourne, Victoria, Australia
Neurobiol Dis 29:490-504. 2008
..Our results show that cognitive deficits in HD mice can be ameliorated by environmental enrichment and suggest that changes in synaptic composition may contribute to the cognitive alterations observed...
- Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners
Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
Laryngoscope 113:1707-13. 2003
..By studying contralateral suppression on cochlear output in subjects of different ages, it is possible to describe aging effects on the medial olivocochlear system...
- Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
J Immunol 168:5558-65. 2002
..Further characterization of the differentially expressed genes may lead to the development of diagnostic tests to monitor the tolerant state...
- Inducible gene targeting in mice
Institute for Genetics, University of Cologne, Germany
Science 269:1427-9. 1995
..Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo...
- Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes
G A Hollander
Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
Nature 373:350-3. 1995
..In addition, a normal thymic architecture is necessary for sustained T-cell ontogeny...
- Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes
Laboratory of Developmental Genetics and Imprinting and Laboratory of Computational Neuroscience, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
Biol Reprod 64:918-26. 2001
..No alterations were detected for the imprinted gene MEST: Preimplantation culture in the presence of serum can influence the regulation of multiple growth-related imprinted genes, thus leading to aberrant fetal growth and development...
- 'Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestine
Lydia M Bogomolnaya
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
Mol Microbiol 70:1105-19. 2008
..Our data suggest that the 12-2 antigen is a S. enterica subspecies I-specific LPS modification that enhances long-term intestinal colonization, and is in contrast to the role of O-antigen variation described for Shigella...
- Dynamic reprogramming of DNA methylation in the early mouse embryo
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
Dev Biol 241:172-82. 2002
..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...
- In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan
Nature 413:639-43. 2001
..We conclude that IgA+ cells in the gut lamina propria are generated in situ from B220+IgM+ lymphocytes...
- Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
D J Rawlings
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
Science 261:358-61. 1993
..A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions...
- Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
Sandra J Cheesman
Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 131:83-91. 2003
- Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF
J A Hamilton
Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia
Arterioscler Thromb Vasc Biol 19:98-105. 1999
- Improved cortical entrainment to infant communication calls in mothers compared with virgin mice
Robert C Liu
W M Keck Center for Integrative Neuroscience, University of California at San Francisco, 513 Parnassus Avenue, USA
Eur J Neurosci 23:3087-97. 2006
..In the broader context, our data suggest that auditory cortical responses to communication sounds are plastic, and that communicative significance is correlated with an improved cortical representation...
- Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance
National Institute of Immunology, New Delhi, India
J Immunol 168:2914-21. 2002
..Thus, Btk is involved in inducing many macrophage effector functions, and delayed mf clearance seen in Btk-deficient xid mice is due to poor NO induction in macrophages, resulting in compromised microfilarial toxicity...
- CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
Sir William Dunn School of Pathology, Oxford, United Kingdom
J Immunol 163:4805-10. 1999
..Our results suggest that, although anti-CD40L Abs are attractive clinical immunotherapeutic agents, additional therapies to control aggressive CD8+ T cell responses may be required...
- In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-gamma mRNA, and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes, and spleens d
G S Henderson
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37212
J Immunol 148:2261-9. 1992
..Hence, this study shows no evidence for increased Th1 cell activity during chronic infection and suggests that modulation may be effected by a generalized suppression of lymphokine synthesis...
- In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
Department of Immunology, Imperial College, Hammersmith Hospital, London, UK
Blood 109:827-35. 2007
..Taken together, these data suggest that in vitro-generated tailored Treg cells could be considered a therapeutic tool to promote donor-specific transplant tolerance...
- Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1
J A Hamilton
Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia
J Leukoc Biol 67:226-32. 2000
- Functional analysis of an arthritogenic synovial fibroblast
Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
Arthritis Res Ther 5:R140-57. 2003
..Our findings support an aggressive role for the SF in the development of the disease and reinforce the perspective of a transformed-like character of the SF...
- Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice
Nigel I Wood
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
Neurobiol Dis 25:342-53. 2007
..We suggest that this is due to the inability of Congo red to cross the blood-brain barrier. Since it does not improve the behavioural deterioration that is a key feature of HD, Congo red is unlikely to be useful as a therapy for HD...
- Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice
M J Guimond
Department of Biomedical Sciences, University of Guelph, Ontario, Canada
Biol Reprod 56:169-79. 1997
..These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success...
- Numerous, robust genetic markers for Plasmodium chabaudi by the method of amplified fragment length polymorphism
University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 123:95-104. 2002
..6 x 10(-4) per base pair. This is consistent with the sequence diversity found between alleles of candidate drug resistance genes from P. c. chabaudi clones AS and AJ identified and sequenced in this laboratory...
- Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants
Robert A Kingsley
Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
Infect Immun 71:629-40. 2003
..These data suggest that colonization of the murine cecum is required for efficient fecal shedding in mice...
- Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
Dev Biol 287:361-77. 2005
..These studies define the major characteristics of testicular and ovarian transcriptional programs and reveal the richness of signaling processes in differentiation of the bipotential gonads into testes and ovaries...
- Identification of regulatory T cells in tolerated allografts
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Exp Med 195:1641-6. 2002
..Our results suggest that T cell suppression of graft rejection is an active process that operates beyond secondary lymphoid tissue, and involves the persistent presence of regulatory T cells at the site of the tolerated transplant...
- Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 281:11846-55. 2006
..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
- The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity
Adv Immunol 33:1-71. 1982
- Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG
Matthew E Rogers
Liverpool School of Tropical Medicine, University of Liverpool, Pembroke Place, Liverpool L3 5QA, UK
Nature 430:463-7. 2004
..These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together...
- Linkage group selection: rapid gene discovery in malaria parasites
Institute of Immunity and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Genome Res 15:92-7. 2005
..We show that molecular markers closely linked to dhfr, and only those linked to this gene, were reduced or removed by pyrimethamine treatment in accordance with the expectations of LGS...
- Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
Division of Medical and Molecular Genetics, GKT School of Medicine, King s College London, UK
Ann Neurol 51:235-42. 2002
..Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease...
- Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
Stephen P Cobbold
Sir William Dunn School of Pathology, Oxford, UK
J Immunol 172:6003-10. 2004
..These data suggest that regulatory T cells maintaining transplantation tolerance after CD4 Ab blockade can be induced de novo through a TGF-beta-dependent mechanism, and come to accumulate in tolerated grafts...
- Spectrotemporal structure of receptive fields in areas AI and AAF of mouse auditory cortex
Jennifer F Linden
Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 90:2660-75. 2003
- GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Am J Transplant 7:759-68. 2007
- Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo
Institute of Reproduction and Development, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
Biol Reprod 62:16-22. 2000
..Therefore it is proposed that the differences in pyruvate and lactate metabolism at the different stages of development are due to differences in the in situ regulation of LDH by cytosolic redox potential...
- Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Transplantation 76:449-55. 2003
- Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
Department of Immunology, Faculty of Medicine, Imperial College London, UK
FASEB J 19:1000-2. 2005
..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
- Orally administered lactoferrin restores humoral immune response in immunocompromised mice
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Immunol Lett 89:9-15. 2003
- Mixed strain schistosome infections of snails and the evolution of parasite virulence
C M Davies
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford
Parasitology 124:31-8. 2002
..Reduced host survival was consistent with an adaptive conditional parasite response...
- Effect of ACE inhibitors and angiotensin II receptor antagonists in a mouse model of colorectal cancer liver metastases
Jaclyn H Neo
Department of Surgery, The University of Melbourne, Austin Hospital, Melbourne, Victoria, Australia
J Gastroenterol Hepatol 22:577-84. 2007
..The aim of this study was to investigate the effect of an ACE-I (captopril) and an AT1R antagonist (irbesartan) in colorectal cancer liver metastases...
- Virulence in rodent malaria: host genotype by parasite genotype interactions
M J Mackinnon
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
Infect Genet Evol 1:287-96. 2002
..Both mortality and morbidity-related factors might therefore influence the upper limit on virulence of malaria parasites...
- Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
Jacobus C de Roode
Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Proc Biol Sci 271:1073-80. 2004
..Host genotype and resistance could therefore play a key role in the outcome of within-host competition between parasite clones and in the evolution of parasite virulence...
- Is ischemia involved in the pathogenesis of murine cerebral malaria?
L A Sanni
Department of Pathology, University of Sydney, Sydney, Australia
Am J Pathol 159:1105-12. 2001
..Mild obstructive ischemia is a likely cause of the metabolic changes during CM, but a role for immune cell effector molecules cannot be ruled out...
- IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 166:3789-96. 2001
- Organ-specific distribution of CD4+ T1/ST2+ Th2 cells in Leishmania major infection
Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
Eur J Immunol 32:2450-9. 2002
..Since the majority of parasites persist at the local site of infection in nonhealing BALB/c mice, these results show that CD4(+) T1/ST2(+) T cells are localized at the site of active infection and inflammation in this model...
- Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice
Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Wrocław, Poland
Med Sci Monit 10:BR84-9. 2004
..The compound induces severe leuko- and neutropenia. Lactoferrin (LF) is a protein which plays a role in the innate immunity. In this study we evaluated the usefulness of LF in reversing CP-induced lympho- and neutropenia in mice...
- Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 72:66-75. 2004
..Intranasal immunization of CBA mice with MBP-MrpH (residues 23 to 157) conferred effective protection against urinary tract infection by P. mirabilis (P < 0.002)...
- Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation
Departments of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105, USA
Am J Pathol 158:1503-15. 2001
..These findings indicate that type-1 and type-2 granulomas display characteristic CK profiles with coordinated expression that is under cytokine-mediated regulation...
- Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 50:265-76. 2004
..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
- Active cell migration drives the unilateral movements of the anterior visceral endoderm
Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 131:1157-64. 2004
- Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice
Nicolas F Delahaye
Laboratoire de Pharmacogénétique des maladies parasitaires EA864, Universite de la Mediterranee IFR48, Marseille, France
J Infect Dis 193:312-21. 2006
- Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+)
Department of Animal Physiology, School of Agriculture, Nagoya University, Japan
J Biol Rhythms 9:51-60. 1994
..These results are discussed in relation to recent findings in retinally degenerate C57BL mice, which have been found to have normal circadian sensitivity to light...
- Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice
School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
Infect Immun 74:2996-3001. 2006
- T cell suppression in transplantation tolerance through linked recognition
J D Davies
Department of Biology and Cancer Center, University of California San Diego, La Jolla, 92093 0063, USA
J Immunol 156:3602-7. 1996
..In addition, our preliminary findings suggest that suppression via linked recognition can also lead to tolerance to the third party Ag...
- Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities
MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
Cell 86:71-82. 1996
..Thus, at least five different eye phenotypes are associated with changes in PAX6 expression. We provide evidence that not only reduced, but also increased levels of transcriptional regulators can cause developmental defects...
- Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:9282-92. 2006
..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
- Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca
Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland 21286, USA
Invest Ophthalmol Vis Sci 47:133-9. 2006
..To develop a mouse model of human chronic dry eye (keratoconjunctivitis sicca [KCS])...
- Animal model of drug-resistant tumor progression
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russian Federation
Ann N Y Acad Sci 1091:490-500. 2006
- Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Nature 376:355-8. 1995
- Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging
Bethany M Tesar
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8018, USA
Aging Cell 5:473-86. 2006
..Therefore, our results demonstrate that myeloid DCs manifest preserved TLR-mediated immune responses with aging. However, aging critically impairs intrinsic adaptive T-cell function...
- Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 52:2708-18. 2005
..To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with generalized osteoporosis, and the mechanisms involved...
- Enhanced proliferative potential in culture of cells from p53-deficient mice
Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Japan
Oncogene 8:3313-22. 1993
..No effects of p53-deficiency were found in proliferation of cardiac muscle cells or hepatocytes...
- Identification of gene markers for the prediction of allograft rejection or permanent acceptance
Institute of Medical Immunology, Charité University Medicine Berlin Campus Mitte, Germany
Am J Transplant 7:1091-102. 2007
..Interestingly, downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro...
- A central role for alpha beta T cells in the pathogenesis of murine lupus
J P Seery
Keratinocyte Laboratory, Lymphocyte Molecular Biology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
J Immunol 162:7241-8. 1999
..Our findings emphasize the relevance of this murine lupus model to the human disease...
- Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
D R Collingridge
PET Oncology Group, Imperial College School of Medicine, Hammersmith Hospital, MRC Cyclotron Building, Du Cane Road, London, W12 0NN, UK
Br J Cancer 84:626-30. 2001
..Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia...
- Evidence that the testis determination pathway interacts with a non-dosage compensated, X-linked gene
P S Burgoyne
Laboratory of Developmental Genetics, National Institute for Medical Research, London, UK
Int J Dev Biol 45:509-12. 2001
..These mice showed similar levels of testicular development to X(M)O mice with the transgene; thus the non-dosage compensated X gene maps outside the PAR...
- Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
J D Thomas
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
Science 261:355-8. 1993
..Because this region of Btk lies outside any obvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function...
- Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
D A Grillot
Department of Pathology, University of Michigan, Ann Arbor 48109 0608, USA
J Exp Med 182:1973-83. 1995
..In contrast to Bcl-2, which has been implicated in the maintenance of mature T cells, Bcl-xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection...
- Identification of the Ped gene at the molecular level: the Q9 MHC class I transgene converts the Ped slow to the Ped fast phenotype
Department of Biology, Northeastern University, Boston, Massachusetts 02115
Biol Reprod 51:695-9. 1994
..In addition, it was found that introduction of the Q9 gene converted the Ped gene phenotype of the recipient strain from slow to fast. Therefore, the Ped gene product is the Qa-2 antigen encoded by the Q9 gene...
- Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 177:1208-13. 2006
..We conclude that nonhemopoietic cells mediate the natural resistance to intestinal amoebiasis of B6 mice, yet this resistance depends on hemopoietic IL-10 activity...
- B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity
Ryohei F Tsuji
Noda Institute for Scientific Research, Chiba ken 278, Japan
J Exp Med 196:1277-90. 2002
..The IgM and challenge antigen likely form local complexes that activate complement, generating C5a, leading to local vascular activation to recruit the antigen-primed effector T cells that mediate the CS response...
- Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen
A E Lukacher
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 181:1683-92. 1995
..These results indicate identity between Pyvs and Mtv-7 sag, and demonstrate a novel mechanism of inherited susceptibility to virus-induced tumors based on effects of an endogenous superantigen on the host's T cell repertoire...
- Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
Sir William Dunn School of Pathology, Oxford, United Kingdom
J Immunol 165:4783-6. 2000
..Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise...
- Uropathogenic Escherichia coli outer membrane antigens expressed during urinary tract infection
Erin C Hagan
Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Infect Immun 75:3941-9. 2007
..coli isolates. Thus, we suggest that the conserved outer membrane antigens identified in this study could be rational candidates for a UTI vaccine designed to elicit protective immunity against UPEC infection...
- Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
Immunobiology 207:197-205. 2003
..In conclusion, we showed for the first time that lactoferrin, given orally to CP-immunosuppressed mice, could reconstitute a T-cell mediated immune response by renewal of the T cell pool...
- Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis
Robert R Langley
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:2971-6. 2003
..The immortalized endothelial cell lines established from H-2K(b)-tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems...
- Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Clin Invest 112:795-808. 2003
..We conclude that robust allogeneic hematopoietic chimerism and central tolerance can be established in the absence of host myeloablative conditioning using a peripheral transplantation tolerance protocol...
- Bacteriophages provide regulatory signals in mitogen-induced murine splenocyte proliferation
Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Rudolfa Weigla 12, 53 114 Wrocław, Poland
Cell Mol Biol Lett 8:699-711. 2003
..This phenomenon may explain the costimulatory activity of phages in the model described...
- Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model
Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, MD, USA
Cornea 26:84-9. 2007
..To compare the effects of topical dry eye medications including anti-inflammatory agents and lubricant eyedrops for the treatment of keratoconjunctivitis sicca (KCS) in a botulinum toxin B (BTX-B)-induced mouse model...
- Mainstream tobacco smoke causes paternal germ-line DNA mutation
Carole L Yauk
Mutagenesis Section, Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
Cancer Res 67:5103-6. 2007
..Our research suggests that the consequences of smoking extend beyond the smoker to their nonsmoking descendents...
- Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice
Imperial College London, Faculty of Medicine, Division of Investigative Science, Department of Immunology, London, UK
Parasite Immunol 25:439-47. 2003
..Thus, we conclude that differences in the age of the mice and in the arginase activity of the different isolates of parasites are factors that can influence the non-healing phenotype of IL-4-/- BALB/c mice...
- CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
Cherry I Kingsley
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Immunol 168:1080-6. 2002
..In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression...
- Noninvasive measurement of rodent intraocular pressure with a rebound tonometer
Wan Heng Wang
Alcon Research, Ltd, Fort Worth, Texas 76134, USA
Invest Ophthalmol Vis Sci 46:4617-21. 2005
..The present study evaluated the applicability of a rebound tonometer in measuring intraocular pressure (IOP) in rats and mice...
- Transcriptome of uropathogenic Escherichia coli during urinary tract infection
Jennifer A Snyder
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA
Infect Immun 72:6373-81. 2004
..This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis...
- Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
Xiao Han Tang
Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
Clin Cancer Res 10:301-13. 2004
..We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis in the mouse oral cavity...
- Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixtures
University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 136:117-22. 2004
..The precision of the method is sufficient to detect reliably the effects of phenotypic selection at loci closely linked to a genetic locus under selection...
- An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi
Institute for Immunology and Infection Research, School of Biological Science, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Malar J 4:11. 2005
..Despite the availability of some genome sequence data, an extensive genetic linkage map is needed for mapping the genes involved in certain traits...
- Apoptin induces apoptosis in an oral cancer mouse model
Remilio A L Schoop
Department of Otolaryngology, Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands
Cancer Biol Ther 7:1368-73. 2008
..The fact that apoptin induces apoptosis in primary squamous cell carcinoma cells indicates that apoptin is a potential therapeutic agent for treatment of head and neck squamous cell carcinoma...
- A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
Eur J Immunol 27:2588-92. 1997
..These results indicate that blocking the activities of both soluble and transmembrane TNF may be required to effectively neutralize the pathogenic potential of this cytokine in arthritis...
- Evaluation of T cell responses in healing and nonhealing leishmaniasis reveals differences in T helper cell polarization ex vivo and in vitro
B S Choi
Department of Immunology, Imperial College London, UK
Parasite Immunol 31:199-209. 2009
..Our results suggest that determination of both ex vivo as well as in vitro T cell responses is crucial to characterize immune responses during experimental leishmaniasis...
- Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
Eur J Immunol 27:1719-25. 1997
..In conclusion, these results indicate that the interaction between membrane TNF and TNFR2 is crucial in the development of this neurological syndrome...
- Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells
Debra M Guyer
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 70:4539-46. 2002
..coli CFT073, elicits defined damage to kidney epithelium during upper urinary tract infection and thus contributes to pathogenesis of urinary tract infection...
- Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
Laboratory of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
Curr Biol 6:1487-96. 1996
- Early treatment during a primary malaria infection modifies the development of cross immunity
Laboratorio de Immunología Molecular, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónomia de Mexico, Iztapalapa, Mexico
Parasite Immunol 26:7-17. 2004
..This finding should be taken into account for the development of effective malaria vaccines...