- Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
Science 282:2085-8. 1998
..Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact...
- MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
Department of Immunology, Saga Medical School, Saga, Japan
J Exp Med 189:1777-82. 1999
..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
- Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
J Exp Med 195:99-111. 2002
..In conclusion, this is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs...
- TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Cell 119:457-68. 2004
..Identification of an I. scapularis receptor for B. burgdorferi is the first step toward elucidating arthropod ligands that are required for survival of spirochetes in nature...
- The Lyme disease agent exploits a tick protein to infect the mammalian host
Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 436:573-7. 2005
..scapularis drastically reduced the capacity of tick-borne spirochaetes to infect mice. These results show the capacity of a pathogen to use a secreted arthropod protein to help it colonize the mammalian host...
- Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
S T Qureshi
Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4
J Exp Med 189:615-25. 1999
..Identification of distinct mutations involving the same gene at the Lps locus in two different hyporesponsive inbred mouse strains strongly supports the hypothesis that altered Tlr4 function is responsible for endotoxin tolerance...
- Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
Department of Biochemistry, Hyogo College of Medicine, Japan
J Immunol 162:3749-52. 1999
..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
- Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Science Center, 407 Reynolds Medical Building, College Station, 77843, USA
Mol Microbiol 59:1591-601. 2006
..burgdorferi-specific pathogenic mechanisms, particularly in the context of dissemination, secondary colonization and/or persistence...
- Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA
J Infect Dis 184:1056-64. 2001
..These results categorize the prominent salivary gland proteins in I. scapularis and demonstrate the presence of a potent antioxidant in tick saliva...
- Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
Sarah C Higgins
Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Immunol 171:3119-27. 2003
..pertussis, which both directly, and by promoting the induction of IL-10-secreting type 1 regulatory T cells, may inhibit Th1 responses and limit inflammatory pathology in the lungs during infection with B. pertussis...
- Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 98:670-5. 2001
..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
- Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
J Clin Invest 111:1589-602. 2003
- Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus
S B Han
Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology KRIBB, 52 Oundong, Yusong, Taejon 305 333, South Korea
Int Immunopharmacol 3:1301-12. 2003
..senticosus, activates B cells and macrophages by interacting with TLRs and leading to the subsequent activation of mitogen-activated protein kinases and NF-kappaB...
- Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Bacteriol 185:4432-41. 2003
..Although vlsE genetic diversity is maintained through tick stages, the VlsE protein is unlikely to be of functional importance in the vector, because the protein was expressed by very few (<1%) bacteria in the vector...
- Altered dopaminergic profiles: implications for the regulation of voluntary physical activity
Amy M Knab
Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
Behav Brain Res 204:147-52. 2009
- MyD88 plays a unique role in host defense but not arthritis development in Lyme disease
Devin D Bolz
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Immunol 173:2003-10. 2004
..The findings presented here point to a dichotomy between the recruitment of inflammatory cells to tissue and an inability of these cells to kill localized spirochetes...
- Coinoculation of Borrelia spp. with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific
N S Zeidner
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
J Parasitol 88:1276-8. 2002
..lusitaniae. Protein profile analysis indicated at least 5 major protein differences between I. scapularis and I. ricinus SGL, which can possibly account for this specific tick-spirochete interaction...
- BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype
Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Infect Immun 72:7147-54. 2004
..The inactivation of BBE02 thus eliminates a transformation barrier for infectious B. burgdorferi B31 and will provide a valuable tool for studying the virulence factors of Lyme disease...
- Differential antigen processing by dendritic cell subsets in vivo
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
Science 315:107-11. 2007
..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
- Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
A M Sangoram
Department of Neurobiology and Physiology and National Science Foundation, Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
Neuron 21:1101-13. 1998
..Taken together, these results demonstrate that mTim and hTIM are mammalian orthologs of timeless and provide a framework for a basic circadian autoregulatory loop in mammals...
- Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
S B Potterf
Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
Hum Genet 107:1-6. 2000
..Our data support a model in which the hypopigmentation in WS, of which these factors have been implicated, results from a disruption in function of the central melanocyte transcription factor MITF...
- T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease
M D McKisic
Center for Comparative Medicine, University of California, Davis, California 95616, USA
Infect Immun 68:5190-7. 2000
..These data demonstrate that B-cell activation during a T-cell-independent response may be critical for resolution of arthritis and carditis and that protective antibodies are generated during this response...
- In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4
Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, and Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
J Infect Dis 183:1617-24. 2001
..Activation of myocardial NF-kappaB was observed within 30 min in C3HeB/FeJ mice but not in C3H/HeJ mice. These findings suggest that myocardial TLR-4 is involved in signaling cytokine production within the heart during endotoxic shock...
- Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil
J Neurosci 29:359-70. 2009
- The extra domain A of fibronectin activates Toll-like receptor 4
Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Biol Chem 276:10229-33. 2001
..These observations provided a mechanism by which EDA-containing fibronectin fragments promote expression of genes involved in the inflammatory response...
- Genome-wide, large-scale production of mutant mice by ENU mutagenesis
M H Hrabe de Angelis
Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
Nat Genet 25:444-7. 2000
..Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html)...
- Bystander elimination of antigen loss variants in established tumors
Michael T Spiotto
Department of Pathology and the Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
Nat Med 10:294-8. 2004
..These results highlight the general importance of targeting the tumor stroma to prevent the escape of variant cancer cells...
- Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease
South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 7824, USA
Infect Immun 76:391-402. 2008
..burgdorferi in select tissues. Infectivity analysis of the BBA64 mutant suggests that B. burgdorferi may utilize multiple determinants to establish infection in mammalian hosts...
- Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi
Laboratory of Immunopathology, Centro de Pesquisas Rene Rachou, FIOCRUZ, Av Augusto de Lima 1715, Barro Preto, 30190 002 Belo Horizonte, MG, Brazil
J Endotoxin Res 10:425-30. 2004
- In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
Jean Christophe Bambou
INSERM, EMI 0212, 156 rue de Vaugirard, 75015 Paris, France
J Biol Chem 279:42984-92. 2004
..These findings provide strong evidence that flagellin released by flagellated commensal bacteria in the intestinal lumen can induce a pro-inflammatory response in enterocytes in vivo...
- Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
J Immunol 171:6466-77. 2003
..The higher ability of 129Sv mice to produce IFN-alpha in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-alpha in vitro in response to viral stimulation...
- Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect
Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
Dev Biol 277:155-69. 2005
..Our study suggests that Sox8 and Sox10 are jointly required for the maintenance of these vagal neural crest stem cells...
- BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
Proskelia Pharmaceuticals, Romainville, France
J Bone Miner Res 18:1842-53. 2003
..The precise role of this cascade in osteoblast differentiation was examined. We show that a Wnt autocrine loop mediates the induction of alkaline phosphatase and mineralization by BMP-2 in pre-osteoblastic cells...
- An enteric helminth infection protects against an allergic response to dietary antigen
Mohamed Elfatih H Bashir
Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 169:3284-92. 2002
..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...
- A vector for expressing foreign genes in the brains and hearts of transgenic mice
D R Borchelt
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
Genet Anal 13:159-63. 1996
..The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain...
- Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
Laboratoire de Physiopathologie Retinienne, Clinique Ophthalmologique, Universite Louis Pasteur, Centre Hospitalier Regional Universitaire, Strasbourg, France
Invest Ophthalmol Vis Sci 40:2724-34. 1999
..To evaluate the neuroprotective potential of glial cell line-derived neurotrophic factor (GDNF) in the retinal degeneration (rd/rd) mouse model of human retinitis pigmentosa...
- Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
M D Lehner
Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
J Immunol 166:5161-7. 2001
- Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
Sheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007
..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
- Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
Mol Cell 5:905-15. 2000
..Together, these results illustrate how the addition of multiple histone modifications may be coupled during the process of gene expression...
- "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
Sabine M Hoelter
Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
Front Biosci 13:5810-23. 2008
..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
- Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
Albert J Chong
Division of Cardiothoracic Surgery, Department of Surgery, The University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Thorac Cardiovasc Surg 128:170-9. 2004
..We used C3H/HeJ mice, which express a nonfunctional toll-like receptor 4, to assess the pertinence of this receptor to tissue injury after reperfusion of ischemic myocardium...
- Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
E Y Lin
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
J Exp Med 193:727-40. 2001
..Our data suggest that agents directed at CSF-1/CSF-1R activity could have important therapeutic effects...
- Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis
Department of Biochemistry, Osaka University Graduate School Faculty of Dentistry, Japan
Mol Biol Cell 14:545-55. 2003
..Thus, BMP2 controls adipocytic differentiation by using two distinct signaling pathways that play differential roles in this process in C3H10T1/2 cells...
- Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene
H V Nielsen
Department of Mycobacteria and Parasitology, Statens Serum Institut, University of Copenhagen, Copenhagen, Denmark
Infect Immun 67:6358-63. 1999
..In conclusion, DNA vaccination with p1tPASAG1 gave effective protection in mice against T. gondii infection and the protection could be adoptively transferred by purified CD8(+) T cells...
- Genetic control of the innate immune response
Christine A Wells
Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia
BMC Immunol 4:5. 2003
- Genetic background determines metabolic phenotypes in the mouse
Marie France Champy
Institut Clinique de la Souris, BP 10142, 67404, Illkirch Cedex, France
Mamm Genome 19:318-31. 2008
- Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
Prashant S Patole
Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
Kidney Int 68:2582-7. 2005
..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation...
- Genetic influence on daily wheel running activity level
J Timothy Lightfoot
Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
Physiol Genomics 19:270-6. 2004
..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex...
- Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Gastroenterology 130:2050-9. 2006
..The normal host immune response to antigens of the enteric microbiota is poorly defined. In this study, we isolated recombinant microbial antigens from commensal bacteria and used them to probe the normal murine immune response...
- Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
J H Hong
Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
Int J Radiat Biol 75:1421-7. 1999
..To investigate cytokine gene expression in the lung after single and fractionated doses of radiation, and to investigate the effect of steroids and the genetic background...
- Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Sci 77:249-57. 2004
..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
- Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
Joel D Schilling
Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:4203-8. 2003
..These results demonstrated that bladder epithelial cells play a critical role in TLR4-mediated innate immunity in vivo during a mucosal bacterial infection...
- Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Science 298:1025-9. 2002
..These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens...
- Plasmid requirements for infection of ticks by Borrelia burgdorferi
Keith O Strother
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Vector Borne Zoonotic Dis 5:237-45. 2005
..This study has pinpointed specific plasmids whose absence is deleterious to infecting nymphal tick guts and salivary glands...
- Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence
Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794 5120, USA
Proc Natl Acad Sci U S A 103:12897-902. 2006
..Thus, tolC is a critical virulence factor of F. tularensis in addition to its role in multidrug resistance, which suggests the presence of a functional type I secretion system...
- Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
Jong Sung Park
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 279:7370-7. 2004
..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
- Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks
K E Hagman
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
Infect Immun 68:4759-64. 2000
..The failure of DbpA immunization to protect tick-challenged mice contradicts the results of earlier needle inoculation vaccination experiments and suggests that DbpA may not be suitable as a Lyme disease vaccine...
- CD14 is required for MyD88-independent LPS signaling
Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
Nat Immunol 6:565-70. 2005
..Thus, the TLR4-MD-2 complex receptor can function in two separate modes: one in which full signaling occurs and one limited to MyD88-dependent signaling...
- Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
J Immunol 164:558-61. 2000
..We conclude that Tlr4 mediates hsp60 signaling. This is the first report of a putative endogenous ligand of the Tlr4 complex...
- Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor
Institut fur Biochemie, Universitat Erlangen Nurnberg, Germany
J Mol Biol 361:11-21. 2006
- The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
Megan S Ford
Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
J Exp Med 196:261-7. 2002
..These findings clearly demonstrate that B6/lpr DNTC have a potent immune regulatory function in vitro and in vivo. They also provide new insights into the mechanisms involved in the development of autoimmune disease in lpr mice...
- Functional modifications in rod bipolar cells in a mouse model of retinitis pigmentosa
Department of Physiology, University of Alcala, Alcala de Henares, E 28871, Madrid, Spain
Vision Res 43:879-85. 2003
..In our opinion, this work describes for the first time the changes in neurotransmitter sensitivity that affect rod bipolar cells after photoreceptor degeneration of the mouse retina...
- Induction of immune cell infiltration into murine SCCVII tumour by photofrin-based photodynamic therapy
Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, Canada
Br J Cancer 71:549-55. 1995
..It seems, therefore, that the PDT-induced acute inflammatory infiltration of myeloid cells into the treated tumour is associated with functional activation of immune cells...
- The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
D H Lynch
Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington 98101
Immunity 1:131-6. 1994
..Thus, the data demonstrate that the gld phenotype is the result of a point mutation in the Fasl gene and that Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome 1...
- C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
F T Liang
Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
Infect Immun 69:3224-31. 2001
..In contrast, antibody to the more conserved invariable region IR(6) of VlsE was present in all of these dog and human serum samples...
- The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
D M Underhill
Department of Immunology, University of Washington, Seattle 98195, USA
Nature 401:811-5. 1999
- Macrophage-independent fungicidal action of the pulmonary collectins
Francis X McCormack
Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
J Biol Chem 278:36250-6. 2003
- Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins
C J Gomer
Clayton Ocular Oncology Center, Childrens Hospital Los Angeles, California 90027, USA
Cancer Res 56:2355-60. 1996
- Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse
MRC Institute of Hearing Research, University Park, Nottingham, U K
Pigment Cell Res 7:17-32. 1994
..Injection of normal neural crest cells into 9.5-day-old mutant embryos increased the extent of skin pigmentation on the head and coat of adult chimeras and was associated with a small increase in the proportion of pigmented strias...
- Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice
Jun ichi Oyama
Department of Cardiovascular Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Mass 02115, USA
Circulation 109:784-9. 2004
..This study assessed the role of TLR4 in myocardial infarction and inflammation in a murine model of ischemia-reperfusion injury...
- Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
Infect Immun 68:54-63. 2000
..Thus, archaeosomes may be potent vaccine carriers capable of facilitating strong primary and memory humoral, and cell-mediated immune responses to the entrapped antigen...
- Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains
W J Hopkins
Department of Surgery, University of Wisconsin, Madison, Wisconsin 43792, USA
Infect Immun 66:2798-802. 1998
..The latter result strongly suggests that the presence or absence of specific host genes will determine how effectively an E. coli UTI will be resolved...
- Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains
Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime, Japan
Arthritis Rheum 46:1067-74. 2002
..To clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gene, lpr (MRL/lpr)...
- Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Immunol 167:5067-76. 2001
..coli LPS, but not P. gingivalis LPS. Therefore, LPS from different bacteria activate DC subsets to produce different cytokines, and induce distinct types of adaptive immunity in vivo...
- Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice
Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
Blood 87:73-82. 1996
- Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10
Joshua S Woodworth
Division of Rheumatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 76:4199-205. 2008
..The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development...
- RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants
Melissa J Caimano
Center for Microbial Pathogenesis, University of Connecticut Health Center, 263 Farmington Ave, Farmington 06030 3710, USA
Infect Immun 72:6433-45. 2004
- The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
Xiao Dong Chen
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 18:948-58. 2004
..However, the response of bgn-deficient osteoblasts to BMP-4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP-4-induced signaling to control osteoblast differentiation...
- Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse
Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226, Japan
Nucleic Acids Res 25:3428-32. 1997
..Peg5/Neuronatin maps to sub-distal Chr 2, proximal to the previously established imprinted region where imprinted genes cause abnormal shape and behavior in neonates...
- IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma
BioXell, Milan, Italy
J Immunol 170:5491-501. 2003
..These data demonstrate that IFN-gamma has a dual role, pathogenic and protective, in IDDM development, and its deletion allows IL-12 to establish alternative pathways leading to diabetes acceleration...
- Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
Celina V Zerbinatti
Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:1075-80. 2004
..These results provide in vivo evidence that LRP may contribute to memory deficits typical of Alzheimer's disease by modulating the pool of small soluble forms of Abeta...
- Resistance to Lyme disease in decorin-deficient mice
E L Brown
The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030, USA
J Clin Invest 107:845-52. 2001
..These differences, which were observed regardless of genetic background of the mice (BALB/c or C3H/HeN) or method of infection, demonstrate the importance of decorin in the pathogenesis of LD...
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
P M Nolan
MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, UK
Nat Genet 25:440-3. 2000
..Our work, along with the programme reported in the accompanying paper, has led to a substantial increase in the mouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics...
- Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
P H Roseboom
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 63:189-97. 1998
..The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity...
- Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation
J N Murdoch
Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
Genomics 78:55-63. 2001
..8 cM on central chromosome 15. Partial penetrance of the craniorachischisis phenotype in Crc/+,Lp/+double heterozygotes suggests the existence of a third, unlinked genetic locus that influences the interaction between Crc and Lp...
- CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
Ian P Lewkowich
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 202:1549-61. 2005
..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
- A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
Joye E Purser
Graduate School of Biomedical Sciences and Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, MSB 2 278, 6431 Fannin St, Houston, TX 77225, USA
Mol Microbiol 48:753-64. 2003
..These results indicate that some plasmid-encoded products fulfil physiological functions required in the enzootic cycle of pathogenic Borrelia...
- Tissue-specific expression and regulation of sexually dimorphic genes in mice
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Genome Res 16:995-1004. 2006
..Moreover, many tissue-specific transcription factor binding sites were found to be enriched in the sexually dimorphic genes...
- Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance
Gavin C O'Brien
Department of Academic Surgery, National University of Ireland, Cork University Hospital, Cork, Ireland
J Immunol 174:1020-6. 2005
..These results indicate that BLP, a TLR2 ligand, protects highly susceptible TLR4-deficient mice from Gram-negative sepsis via enhanced bacterial clearance...
- Integrating genetic and network analysis to characterize genes related to mouse weight
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
PLoS Genet 2:e130. 2006
..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
- Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
J Exp Med 197:403-11. 2003
..These findings provide the first evidence that Treg respond directly to proinflammatory bacterial products, a mechanism that likely contributes to the control of inflammatory responses...
- Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region
Howard Hughes Medical Institute, Dallas, TX 75235 9050, USA
Blood Cells Mol Dis 24:340-55. 1998
..Only a single intact gene was identified within the entire critical region. This gene encodes the Toll-4 receptor, a member of the IL-1 receptor family...
- Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families
Carl J Johnston
University of Rochester, Department of Pediatrics, Environmental Medicine, and Radiation Oncology, Rochester, New York 14642, USA
Radiat Res 157:256-65. 2002
..These studies suggest that monocyte/macrophage and lymphocyte recruitment and activation are key components of radiation-induced fibrosis...
- Genetic variation for body weight change in mice in response to physical exercise
Larry J Leamy
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
BMC Genet 10:58. 2009
- Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages
Graduate School of Medical Science and Engineering, Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
Blood 113:2605-13. 2009
..In conclusion, TLR4 in LECs plays an essential role in LPS-induced inflammatory lymphangiogenesis by chemotactic recruitment of macrophages...
- Toll-like receptor 4-mediated activation of murine mast cells
J D McCurdy
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
J Leukoc Biol 70:977-84. 2001
..These findings have important implications for the mechanism of mast cell responses to pathogens and their products and suggest that different TLR4-expressing cells might have different thresholds for activation with LPS...
- Ipr1 gene mediates innate immunity to tuberculosis
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 434:767-72. 2005
..Our data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis...
- Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks
Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS Pathog 3:e33. 2007
..Taken together, these data suggest that OspB has an important role within Ixodes scapularis and that B. burgdorferi relies upon multiple genes to efficiently persist in ticks...
- Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
Sarah M Fortune
Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
J Immunol 172:6272-80. 2004
..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Science 265:808-11. 1994
..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
- A phenotype-based screen for embryonic lethal mutations in the mouse
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, and the Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:7485-90. 1998
..Two mutations produce novel early phenotypes and map to regions of the genome not previously implicated in embryonic patterning...