- The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006
..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
Janine L Coombes
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
J Exp Med 204:1757-64. 2007
..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
- T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Thorsten R Mempel
The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 427:154-9. 2004
- An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
M B Lutz
Department of Dermatology, University of Erlangen, Germany
J Immunol Methods 223:77-92. 1999
..This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations. It will be valuable to study DC biology notably at the molecular level...
- Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
Immunity 17:375-87. 2002
..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
- Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
J Exp Med 192:303-10. 2000
..This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity...
- The immunology of susceptibility and resistance to Leishmania major in mice
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 2:845-58. 2002
..major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses...
- Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Cancer Res 66:1123-31. 2006
..Our data provide evidence that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses...
- IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
M M Fort
DNAX Research Institute, Palo Alto, CA 94304, USA
Immunity 15:985-95. 2001
..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
- Development of a human adaptive immune system in cord blood cell-transplanted mice
Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
Science 304:104-7. 2004
..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
- OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Y Y Kong
Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
Nature 397:315-23. 1999
..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
- CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
J Immunol 170:394-9. 2003
..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
- CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
Rebecca S McHugh
Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 16:311-23. 2002
..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
- Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
D F Fiorentino
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
J Exp Med 170:2081-95. 1989
..The potential role of CSIF in crossregulation of Th1 and Th2 responses is discussed...
- Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
Susanne J Szabo
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Science 295:338-42. 2002
..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 2:261-8. 2001
..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
- Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
Alexander S Pym
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
Mol Microbiol 46:709-17. 2002
..Knocking-in five other RD loci did not affect the virulence of BCG. This study describes a genetic lesion that contributes to safety and opens new avenues for vaccine development...
- Chitin induces accumulation in tissue of innate immune cells associated with allergy
Tiffany A Reese
Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
Nature 447:92-6. 2007
..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...
- In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
Nature 460:1021-5. 2009
..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
- Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
Immunity 11:141-51. 1999
..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
- HMG-1 as a late mediator of endotoxin lethality in mice
Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
Science 285:248-51. 1999
..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
- G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Nat Immunol 3:687-94. 2002
..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
- Cloning of a new cytokine that induces IFN-gamma production by T cells
Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
Nature 378:88-91. 1995
..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions...
- New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
Liver Cancer Institute and Zhong Shan Hospital, Shanghai Medical University, Peoples Republic of China
Br J Cancer 81:814-21. 1999
..PCR products of HBsAg and HBxAg were both positive. The cell line MHCC97 still retained some characteristic features of original tumour. Establishment of cell line MHCC97 should be beneficial to the studies of HCC metastatic mechanisms...
- Expression of programmed death 1 ligands by murine T cells and APC
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Immunol 169:5538-45. 2002
..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
- Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
Department of Immunology, Faculty of Medicine, Imperial College London, UK
FASEB J 19:1000-2. 2005
..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
- Control of regulatory T cell development by the transcription factor Foxp3
Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
Science 299:1057-61. 2003
..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
- Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 93:3444-9. 1996
..Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells...
- Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Sandra S Diebold
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
Science 303:1529-31. 2004
..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
- T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
S P Schoenberger
Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
Nature 393:480-3. 1998
..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
- CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
Cell 99:23-33. 1999
..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
- Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
Cytos Biotechnology, Schlieren, Switzerland
J Immunol 172:5598-605. 2004
- Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
Suzanne L Epstein
Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Bethesda, MD 20852, USA
Vaccine 23:5404-10. 2005
..Thus, gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity...
- Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
Padraic G Fallon
Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Exp Med 203:1105-16. 2006
..We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion...
- In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
Immunity 17:211-20. 2002
..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
- The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
Patricia A Taylor
University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis 55455, USA
Blood 99:3493-9. 2002
..CD4(+)CD25(+) cells warrant consideration as an exciting new modality of cellular therapy for the inhibition of undesirable autologous and allogeneic responses...
- Arthritis critically dependent on innate immune system players
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Immunity 16:157-68. 2002
..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
- B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
S Y Tseng
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Exp Med 193:839-46. 2001
..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
- The role of IL-10 in promoting disease progression in leishmaniasis
M M Kane
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Immunol 166:1141-7. 2001
..This IgG allows amastigotes to exploit the antiinflammatory effects of Fc gamma R ligation to induce the production of IL-10, which renders macrophages refractory to the activating effects of IFN-gamma...
- Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
Science 291:319-22. 2001
..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...
- Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
Nat Immunol 2:725-31. 2001
..These studies show that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen...
- Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
J Exp Med 198:615-21. 2003
..These results indicate that DC number and tissue inflammation are critical parameters for DC-based vaccination...
- Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
M S Jordan
The Wistar Institute, Philadelphia, PA 19104, USA
Nat Immunol 2:301-6. 2001
..Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion...
- Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
Fred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Immunol Rev 201:139-55. 2004
- High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
J Exp Med 192:565-70. 2000
..Together, these results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis...
- Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
Immunology Section, BMC D14, 221 84 Lund University, Lund, Sweden
J Exp Med 205:2139-49. 2008
..Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal inflammatory responses...
- Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
S J Szabo
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 185:817-24. 1997
..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
- Organ-specific disease provoked by systemic autoimmunity
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
Cell 87:811-22. 1996
..We suggest that human RA develops by an analogous mechanism...
- IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
Immunity 6:541-9. 1997
..Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of V beta 4 V alpha 8 CD4+ T cells after cognate interaction with a single antigen from this complex organism...
- Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
Blood 105:4743-8. 2005
..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
- Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
J Bacteriol 184:4177-86. 2002
..The PSA prophage DNA sequence reconstitutes a complete tRNA(Arg) gene. The modified vector, pPL2, was integration proficient at the same frequency as pPL1 in common laboratory serotype 1/2 strains as well as serotype 4b strains...
- Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Istituto Oncologico Veneto, Padua, Italy
J Clin Invest 116:2777-90. 2006
..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
- Suppression of allergic airway inflammation by helminth-induced regulatory T cells
Mark S Wilson
Institute of Immunology and Infection Research, University of Edinburgh, UK
J Exp Med 202:1199-212. 2005
..These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo...
- Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 194:629-44. 2001
..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
- Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
Nature 409:1055-60. 2001
..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
- A multigenic program mediating breast cancer metastasis to bone
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Cancer Cell 3:537-49. 2003
- Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma
V P Badovinac
Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
Science 290:1354-8. 2000
..Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules...
- Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Immunity 14:617-29. 2001
- Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
Matthew D Taylor
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
Eur J Immunol 39:192-206. 2009
..These CD4(+)Foxp3(+) Treg cells are predominantly recruited from the 'natural' regulatory pool and act to inhibit protective immunity over the full course of infection...
- Deacetylase inhibition promotes the generation and function of regulatory T cells
Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
Nat Med 13:1299-307. 2007
..Our data show that use of HDACi allows the beneficial pharmacologic enhancement of both the numbers and suppressive function of Foxp3(+) T(reg) cells...
- New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25
Stephen D Hurst
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
J Immunol 169:443-53. 2002
..Further, these data demonstrate the heterogeneity of function within the IL-17 cytokine family and suggest that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13, and eotaxin...
- The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
Kota Arun Kumar
Michael Heidelberger Division of Immunology, Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
Nature 444:937-40. 2006
..Thus, although hundreds of other Plasmodium genes are expressed in sporozoites and EEFs, CS is a dominant protective antigen. Nevertheless, sterile immunity could be obtained by immunization of CS transgenics with three doses of IrSp...
- Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major
Faculty of Medicine, Department of Immunology, Imperial College London, London, United Kingdom
Infect Immun 72:1920-8. 2004
..This is the first study showing that TLR4 contributes to the effective control of Leishmania infection in vivo...
- Stromal cells direct local differentiation of regulatory dendritic cells
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Immunity 21:805-16. 2004
..The ability of tissue stromal cells to direct the development of DC with a regulatory phenotype thus provides a new mechanism for local immune regulation...
- IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 448:484-7. 2007
..We show that an IL-2 cytokine family member, IL-21, cooperates with TGF-beta to induce T(H)17 cells in naive Il6-/- T cells and that IL-21-receptor-deficient T cells are defective in generating a T(H)17 response...
- Epigenetic control of the foxp3 locus in regulatory T cells
Experimentelle Rheumatologie, Charite Universitaetsmedizin Berlin, Berlin, Germany
PLoS Biol 5:e38. 2007
- B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Immunity 6:303-13. 1997
..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
- Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Cell 117:927-39. 2004
..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
- A novel transcription factor, T-bet, directs Th1 lineage commitment
S J Szabo
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cell 100:655-69. 2000
..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
- Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 203:2841-52. 2006
..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
- Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
Laura J Cliffe
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Science 308:1463-5. 2005
..This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense...
- Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
Jill R Johnson
Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
Am J Respir Crit Care Med 169:378-85. 2004
..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly...
- Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 99:12293-7. 2002
- Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
Nat Immunol 3:135-42. 2002
..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
- Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
Nat Immunol 6:769-76. 2005
..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
- T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
J Exp Med 204:41-7. 2007
..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
- Migration of Plasmodium sporozoites through cells before infection
M M Mota
Department of Pathology, New York University School of Medicine, 341 East 25 Street, New York, NY 10010, USA
Science 291:141-4. 2001
..Sporozoite migration through several cells in the mammalian host appears to be essential for the completion of the life cycle...
- Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
J Exp Med 196:389-99. 2002
..Our results demonstrate that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells can determine the outcome of aGVHD...
- Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
I D Iliev
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Mucosal Immunol 2:340-50. 2009
..Thus, we have uncovered an essential mechanism in which EC control of DC function is required for tolerance induction...
- CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
Thomas R Malek
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
Immunity 17:167-78. 2002
..These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4(+)CD25(+) regulatory T cells...
- Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
University of Milano-Bicocca, Department of Biotechnology and Bioscience, Piazza della Scienza 2, Milan, Italy
Nat Immunol 2:882-8. 2001
..In contrast, macrophages did not produce IL-2 upon bacterial stimulation. Thus, IL-2 is an additional key cytokine that confers unique T cell stimulatory capacity to DCs...
- Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
Kathryn B Renegar
Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Immunol 173:1978-86. 2004
- Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
Stephen P Saville
Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Eukaryot Cell 2:1053-60. 2003
..albicans pathogenesis. This engineered strain should provide a useful tool in unraveling the individual contributions of the yeast and filamentous forms at various stages of the infectious process...
- Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
Nat Med 13:703-10. 2007
..These effects were mediated by the binding of CO to hemoglobin, preventing hemoglobin oxidation and the generation of free heme, a molecule that triggers ECM pathogenesis...
- Aquatic insects as a vector for Mycobacterium ulcerans
Laboratoire de bactériologie virologie hygiène, CHU, 49033 Angers, France
Appl Environ Microbiol 68:4623-8. 2002
..ulcerans from wild aquatic insects collected from a zone in the Daloa region of Ivory Coast where Buruli ulcer is endemic. Taken together, these results point to aquatic insects as a possible vector of M. ulcerans...
- Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Exp Med 204:3133-46. 2007
..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
- Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
R A Clynes
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
Nat Med 6:443-6. 2000
- Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1875-86. 2003
..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
- Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
J Immunol 174:636-45. 2005
..These mechanisms occur in STAT6(-/-) mice because STAT6 deficiency prevents signaling through the type 2 IL-4Ralpha, thereby blocking the production of arginase and promoting the synthesis of NO...
- Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
J Exp Med 203:2691-702. 2006
..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy...
- The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
Nature 375:151-5. 1995
..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
- Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
Research Institute of Molecular Pathology, 1030 Vienna, Austria
Nat Immunol 8:351-8. 2007
..Thus, 'routing' of mTEC-derived self antigens may determine whether specific thymocytes are deleted or enter the regulatory T cell lineage...
- Inducing and expanding regulatory T cell populations by foreign antigen
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Immunol 6:1219-27. 2005
..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
- Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
PLoS Pathog 3:e110. 2007
..tuberculosis and support a direct causal relationship between virulence of pathogenic mycobacteria and their ability to inhibit macrophage apoptosis...
- ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Molecular Immunology, Robert Koch Institut, Berlin, Germany
Nature 397:263-6. 1999
..Our results indicate that ICOS is another major regulator of the adaptive immune system...
- Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow
Department of Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
J Exp Med 194:1151-64. 2001
..Mice in which RAG-2 was deleted at birth maintained a small population of activated B cells with an increased proportion of marginal zone B cells. Additionally, an increase of the pool of IgM secreting cells and B-1a cells was observed...
- Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS Pathog 3:1374-9. 2007
- MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
Picower Institute for Medical Research, Manhasset, New York 11030
Nature 365:756-9. 1993
..We conclude that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock...
- Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
Proc Natl Acad Sci U S A 99:13031-6. 2002
..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
D J Berg
Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
J Clin Invest 98:1010-20. 1996
..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
- Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
Robert M Anthony
Department of Medicine, New Jersey Medical School, 185 S Orange Avenue, Newark, New Jersey 07103, USA
Nat Med 12:955-60. 2006