inbred strains mice

Summary

Summary: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Top Publications

  1. pmc Efficient control of population structure in model organism association mapping
    Hyun Min Kang
    Department of Computer Science, University of California, Los Angeles, California 90095 1596, USA
    Genetics 178:1709-23. 2008
  2. pmc Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization
    Denise M Monack
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Exp Med 199:231-41. 2004
  3. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
  4. pmc The recombinational anatomy of a mouse chromosome
    Kenneth Paigen
    Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 4:e1000119. 2008
  5. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
  6. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
  7. ncbi The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
  8. pmc Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse
    Jennifer L Moran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 16:436-40. 2006
  9. pmc Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    Mathias Lucas
    Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 26:503-17. 2007
  10. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005

Research Grants

  1. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2010
  2. MOLECULAR GENETICS OF LUNG TUMOR PROMOTION IN MICE
    Ming You; Fiscal Year: 2009
  3. MOLECULAR GENETICS OF LUNG TUMOR PROMOTION IN MICE
    MING contact YOU; Fiscal Year: 2010
  4. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
  5. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
  6. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
  7. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
  8. MECHANISMS OF MNU INDUCED LYMPHOMA IN AKR MICE
    Ellen Richie; Fiscal Year: 1992
  9. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 1999
  10. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001

Detail Information

Publications299 found, 100 shown here

  1. pmc Efficient control of population structure in model organism association mapping
    Hyun Min Kang
    Department of Computer Science, University of California, Los Angeles, California 90095 1596, USA
    Genetics 178:1709-23. 2008
    ..An R package implementation and webserver of our EMMA method are publicly available...
  2. pmc Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization
    Denise M Monack
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Exp Med 199:231-41. 2004
    ..Thus, interferon-gamma, which may affect the level of macrophage activation, plays an essential role in the control of the persistent S. typhimurium infection in mice...
  3. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..In the forced swim test, 10 and 18 mg/kg/day increased swimming and reduced immobility. Here we present several novel effects of chronic, but not subchronic, antidepressant treatment...
  4. pmc The recombinational anatomy of a mouse chromosome
    Kenneth Paigen
    Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 4:e1000119. 2008
    ..It appears that the regulation of mammalian recombination is a complex, dynamic process involving multiple factors reflecting species, sex, individual variation within species, and the properties of individual hotspots...
  5. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
    ..These results demonstrate, for the first time, that the increase of SWS need is under a strong genetic control, and they provide a basis for identifying genes underlying SWS homeostasis...
  6. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  7. ncbi The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  8. pmc Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse
    Jennifer L Moran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 16:436-40. 2006
    ..By using this approach, we identified DNA sequence changes in two ethylnitrosourea-induced mutants...
  9. pmc Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    Mathias Lucas
    Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 26:503-17. 2007
    ..Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system...
  10. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005
    ..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo...
  11. ncbi Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment
    William A Gomes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 255:164-77. 2003
    ..Therefore, BMPs are likely important mediators of astrocyte development in vivo...
  12. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..Under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death...
  13. pmc Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    Akiko Watanabe
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS Biol 5:e297. 2007
    ..We also discuss the results from the perspective of fetal programming...
  14. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
    ....
  15. ncbi Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    Prapaporn Pisitkun
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, NIH, Rockville, MD 20852, USA
    Science 312:1669-72. 2006
    ..These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation...
  16. pmc The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin
    B Engelhardt
    Max Planck Institut fur Physiologische und Klinische Forschung, W G Kerckhoff Institut, Bad Nauheim, Germany
    J Clin Invest 102:2096-105. 1998
    ..Furthermore, our in vitro studies suggest that the therapeutic effect of anti-alpha4-treatment of EAE might also be caused by inhibition of antigen-specific T cell proliferation...
  17. pmc Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism
    H Kanno
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Clin Exp Immunol 89:68-73. 1992
    ..This may present a useful concept for analysis of the developmental mechanisms of human chronic pancreatitis in an aspect of autoimmunity...
  18. pmc The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008
    ..Herein we present a progress report of the Collaborative Cross breeding program at ORNL and a description of the kinds of investigations that this resource will support...
  19. pmc Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells
    Nicolas Quoix
    Unit of Endocrinology and Metabolism, University of Louvain Faculty of Medicine, Brussels, Belgium
    Diabetes 58:412-21. 2009
    ..We studied how glucose and ATP-sensitive K(+) (K(ATP)) channel modulators affect alpha-cell [Ca(2+)](c)...
  20. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  21. doi Genetic susceptibility and resistance to influenza infection and disease in humans and mice
    Rita A Trammell
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9616, USA
    Expert Rev Mol Diagn 8:515-29. 2008
    ..Relying heavily on what we have learned from mice, this overview summarizes existing animal, human and epidemiologic data suggestive of host genetic influences on influenza infection...
  22. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  23. pmc A highly efficient recombineering-based method for generating conditional knockout mutations
    Pentao Liu
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:476-84. 2003
    ..This method should also facilitate the generation of knock-in mutations and transgene constructs, as well as expedite the analysis of regulatory elements and functional domains in or near genes...
  24. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
    ..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
  25. pmc Mouse segmental duplication and copy number variation
    Xinwei She
    Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, USA
    Nat Genet 40:909-14. 2008
    ..We show large and complex patterns of interstrain copy number variation restricted to large gene families associated with spermatogenesis, pregnancy, viviparity, pheromone signaling and immune response...
  26. ncbi Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice
    G W M Bothe
    Taconic Farms, Hover Avenue, Germantown, NY, USA
    Genes Brain Behav 3:149-57. 2004
    ..Contrary to earlier studies, we found that all strains habituated to the open field in at least two of these parameters (center distance and velocity)...
  27. ncbi Polygenic control of susceptibility to murine systemic lupus erythematosus
    L Morel
    Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610
    Immunity 1:219-29. 1994
    ..Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system...
  28. ncbi The influence of genetic background on the expression of the obese (Ob) gene in the mouse
    D L Coleman
    Diabetologia 9:287-93. 1973
  29. ncbi Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice
    Susanne Neschen
    Howard Hughes Medical Institute, Yale Medical School, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:924-8. 2006
    ..These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat...
  30. ncbi The mouse model of collagen-induced arthritis
    David D Brand
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, USA
    Methods Mol Med 102:295-312. 2004
    ....
  31. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  32. pmc Nestin-positive mesenchymal stem cells favour the astroglial lineage in neural progenitors and stem cells by releasing active BMP4
    Sabine Wislet-Gendebien
    Centre for Cellular and Molecular Neurobiology, University of Liege, Liege, Belgium
    BMC Neurosci 5:33. 2004
    ..Alternatively, several reports suggested that mesenchymal stem cells, isolated from adult bone marrow, are multipotent cells and could be used in autograft approach for replacement therapies...
  33. ncbi Inbred strain differences in prepulse inhibition of the mouse startle response
    R Paylor
    Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 132:169-80. 1997
    ..There was no correlation between the level of prepulse inhibition and the amplitude of the startle response. These findings indicate that inbred strains of mice may be a useful tool to study the genetic basis of sensorimotor gating...
  34. ncbi Ikaros sets thresholds for T cell activation and regulates chromosome propagation
    N Avitahl
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Immunity 10:333-43. 1999
    ..Proliferating T cells with reduced Ikaros activity display chromosome abnormalities. We propose that participation of Ikaros in higher-order chromatin structures controls cell cycle transitions and restricts DNA replication...
  35. ncbi Gene interaction and single gene effects in colon tumour susceptibility in mice
    T van Wezel
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Genet 14:468-70. 1996
    ..These findings and the accompanying paper on lung tumour susceptibility show that interlocus interactions are likely to be an important component of tumour susceptibility...
  36. ncbi Toll-dependent selection of microbial antigens for presentation by dendritic cells
    J Magarian Blander
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nature 440:808-12. 2006
    ..Furthermore, we show that the generation of peptide-MHC class II complexes is controlled by TLRs in a strictly phagosome-autonomous manner...
  37. pmc Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
    M Shlomchik
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Exp Med 171:265-92. 1990
    ....
  38. ncbi Genetic control of melatonin synthesis in the pineal gland of the mouse
    S Ebihara
    Science 231:491-3. 1986
    ..Pineal glands from C57BL/6J mice have neither NAT nor HIOMT activity. These results suggest that the two genes involved in melatonin deficiency are responsible for the absence of normal NAT and HIOMT enzyme activity...
  39. pmc Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
    M G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genet 2:1. 2001
    ..The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty...
  40. pmc Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number
    G D Rosen
    Dyslexia Research Laboratory and Charles A, Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BMC Neurosci 2:5. 2001
    ..We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia...
  41. pmc Hemophagocytic macrophages harbor Salmonella enterica during persistent infection
    Rebecca N Nix
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America
    PLoS Pathog 3:e193. 2007
    ..These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche...
  42. ncbi Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  43. ncbi Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse
    Petko M Petkov
    The Jackson Laboratory, Technology Development, Bar Harbor, ME 04609, USA
    Genomics 83:902-11. 2004
    ....
  44. ncbi Genetic, sex, and diet effects on body weight and obesity in the Berlin Fat Mouse Inbred lines
    Asja Wagener
    Institute of Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
    Physiol Genomics 27:264-70. 2006
    ..Our results demonstrate that the genetically related BFMI lines are novel models to study the genetic as well as the nutritional aspects of obesity...
  45. pmc Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus
    Gundula Min-Oo
    Department of Biochemistry, The Research Institute of McGill University Health Centre, McGill University, Montreal H3G 1Y6, Quebec, Canada
    J Exp Med 204:511-24. 2007
    ..These studies suggest that pantetheinase is critical for the host response to malaria...
  46. ncbi Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 22:37-43. 1999
    ..Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation...
  47. ncbi Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  48. ncbi Effects of repeated maternal separation on prepulse inhibition of startle across inbred mouse strains
    R A Millstein
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, MD 20852, USA
    Genes Brain Behav 5:346-54. 2006
    ..The development and validation of a reliable mouse model of early life stress remains an important research goal...
  49. ncbi Endoplasmic reticulum (ER) stress induced by a neurovirulent mouse retrovirus is associated with prolonged BiP binding and retention of a viral protein in the ER
    Derek E Dimcheff
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:33782-90. 2004
    ..Thus, the ER stress induced by FrCasE appears to be initiated by inefficient folding of its viral envelope protein, suggesting that the neurodegenerative disease caused by this virus represents a protein misfolding disorder...
  50. ncbi MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells
    J S Arthur
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 482:44-8. 2000
    ..Thus MSK1 is required for CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells...
  51. pmc In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets
    Andreas Beilhack
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    Blood 106:1113-22. 2005
    ..These findings underline the potential of T-cell subsets with defined trafficking patterns for immune reconstitution without the risk of GVHD...
  52. pmc Haplotype analysis in multiple crosses to identify a QTL gene
    Xiaosong Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 14:1767-72. 2004
    ..These findings support Apoa2 as the underlying Hdlq5 gene and suggest the Apoa2 polymorphisms responsible for the Hdlq5 phenotype. Therefore, haplotype analysis in multiple crosses can be used to support a candidate QTL gene...
  53. pmc A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
    M Sibilia
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 17:719-31. 1998
    ..Since EGFR is expressed in the affected cell-types, these results define a specific function for EGFR in the proliferation and/or differentiation of astrocytes and in the survival of postmitotic neurons...
  54. ncbi Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod
    M P McFadyen
    Genomics Institute, Wadsworth Center Jordan Road, Troy, New York 12180, USA
    Genes Brain Behav 2:214-9. 2003
    ..Thus, we have demonstrated a genetic component in rotorod performance, and we have shown that factors other than inherent motor ability can contribute to rotorod performance in mice...
  55. pmc Assessing autism-like behavior in mice: variations in social interactions among inbred strains
    Valerie J Bolivar
    Wadsworth Center, Troy, NY 12180, USA
    Behav Brain Res 176:21-6. 2007
    ..g., autism)...
  56. ncbi Antibody-mediated clearance of alphavirus infection from neurons
    B Levine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 254:856-60. 1991
    ..Thus, antibody can mediate clearance of alphavirus infection from neurons by restricting viral gene expression...
  57. pmc p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
    G I Topley
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 96:9089-94. 1999
    ..Thus, these findings have revealed a function of p21 as a suppressor of malignant but not benign skin-tumor formation and a determinant of the growth/differentiation potential of keratinocyte subpopulations...
  58. ncbi Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort
    David W Threadgill
    Department of Genetics, CB 7264, Lineberger Comprehensive Cancer Center, Rm 11 109, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mamm Genome 13:175-8. 2002
  59. pmc The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    Giuseppina Caretti
    Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 18:2627-38. 2004
    ....
  60. ncbi Immunodomination results from functional differences between competing CTL
    G Roy-Proulx
    Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
    Eur J Immunol 31:2284-92. 2001
    ....
  61. ncbi Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice
    Michael D Faulx
    Division of Cardiology, Dept of Medicine, Univ Hospitals of Cleveland and Case Western Reserve Univ, MS 5038, 11100 Euclid Ave, Cleveland, OH 44106 5038, USA
    Am J Physiol Heart Circ Physiol 289:H30-6. 2005
    ..Abnormalities in beta-adrenergic regulation may contribute to strain-related differences in the vulnerability to isoproterenol-induced cardiac changes...
  62. pmc Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice
    F E Johansen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Exp Med 190:915-22. 1999
    ..Production of SIgA might therefore be a variable in the initiation of human immunopathology such as inflammatory bowel disease or gluten-sensitive enteropathy...
  63. ncbi The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection
    Laura J Cliffe
    School of Biological Sciences, University of Manchester, Stopford Building, Manchester M13 9PT, UK
    Adv Parasitol 57:255-307. 2004
    ....
  64. ncbi Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    Hisashi Arase
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Science 296:1323-6. 2002
    ..These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen...
  65. pmc An efficient SNP system for mouse genome scanning and elucidating strain relationships
    Petko M Petkov
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 14:1806-11. 2004
    ..Applying a neighbor-joining method to the data, we constructed a mouse strain family tree, which in most cases confirmed existing genealogies...
  66. ncbi Olfactory fingerprints for major histocompatibility complex-determined body odors II: relationship among odor maps, genetics, odor composition, and behavior
    Michele L Schaefer
    Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 22:9513-21. 2002
    ..These data on natural odors are consistent with the combinatorial code hypothesis and identify subsets of glomeruli that are apt to play a significant role in mediating individual recognition...
  67. pmc An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes
    Aideen O'Doherty
    Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Science 309:2033-7. 2005
    ..Transchromosomic mouse lines such as Tc1 may represent useful genetic tools for dissecting other human aneuploidies...
  68. pmc Comparative recombination rates in the rat, mouse, and human genomes
    Michael I Jensen-Seaman
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 14:528-38. 2004
    ..This comparative approach provides additional insight into the causes and consequences of genomic heterogeneity in recombination...
  69. ncbi The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    P Riley
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Genet 18:271-5. 1998
    ..Their heart tubes showed abnormal looping and ventricular myocardial differentiation. Therefore, Hand1 is essential for differentiation of both trophoblast and cardiomyocytes, which are embryologically distinct cell lineages...
  70. ncbi Transient caloric restriction in early adulthood hastens disease endpoint in male, but not female, Cu/Zn-SOD mutant G93A mice
    Mazen J Hamadeh
    Department of Pediatrics, Rm 2H26, McMaster University Medical Center, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
    Muscle Nerve 34:709-19. 2006
    ..Assuming we can extrapolate these results to humans, short-term CR should be avoided in patients with amyotrophic lateral sclerosis, especially men...
  71. ncbi Genetic background determines the size and structure of the endocrine pancreas
    Troels Bock
    Research Laboratory for Stereology and Neuroscience, H S Bispebjerg Hospital, Copenhagen University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Diabetes 54:133-7. 2005
    ..We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas...
  72. ncbi Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
    K E Browman
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Alcohol Clin Exp Res 24:17-23. 2000
    ..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
  73. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
    ..Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits...
  74. ncbi Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice
    G Pitari
    Dipartmento di Biologia di Base ed Applicata Università di L Aquila, Italy
    FEBS Lett 483:149-54. 2000
    ....
  75. ncbi Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
    E Barbacci
    U423 INSERM, Hopital Necker Enfants Malades, France U257 INSERM, ICGM, France
    Development 126:4795-805. 1999
    ....
  76. ncbi On the subspecific origin of the laboratory mouse
    Hyuna Yang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 39:1100-7. 2007
    ....
  77. doi Segmental copy number variation shapes tissue transcriptomes
    Charlotte N Henrichsen
    The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Nat Genet 41:424-9. 2009
    ..Dosage alterations of brain-expressed genes are less frequent than those of other genes and are buffered by tighter transcriptional regulation. Our study provides initial evidence that CNVs shape tissue transcriptomes on a global scale...
  78. ncbi Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations
    Karen L Svenson
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    J Appl Physiol (1985) 102:2369-78. 2007
    ..Data generated by this effort builds on the value of inbred mouse strains as a powerful tool for biomedical research...
  79. ncbi Home cage activity and activity-based measures of anxiety in 129P3/J, 129X1/SvJ and C57BL/6J mice
    Xiangdong Tang
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501, USA
    Physiol Behav 84:105-15. 2005
    ..The findings illustrate that test variations and experience can influence performance and suggest the need for the consideration of how these factors interact with background strains in assessing gene-altered mice...
  80. ncbi Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition
    Daniel Kreisel
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Nat Med 8:233-9. 2002
    ....
  81. pmc Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
    ..These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells...
  82. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  83. pmc Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci
    Giacomo Manenti
    Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    PLoS Genet 5:e1000331. 2009
    ..Our results indicate that GWA studies in mouse inbred strains can suffer a high rate of false-positive results and that such an approach should be used in conjunction with classical linkage mapping in genetic crosses...
  84. pmc Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    S T Qureshi
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4
    J Exp Med 189:615-25. 1999
    ..Identification of distinct mutations involving the same gene at the Lps locus in two different hyporesponsive inbred mouse strains strongly supports the hypothesis that altered Tlr4 function is responsible for endotoxin tolerance...
  85. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    ..These findings uncover a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status...
  86. pmc Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull
    Y H Liu
    Department of Biochemistry and Molecular Biology, Kenneth R Norris Cancer Hospital and Institute, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 92:6137-41. 1995
    ..These mice provide a transgenic model of craniosynostosis as well as a point of entry into the molecular mechanisms that coordinate the growth of the brain and skull...
  87. pmc Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies
    Sona Gregorova
    Institute of Molecular Genetics, Department of Mouse Molecular Genetics, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic
    Genome Res 18:509-15. 2008
    ..PWD-mt conplastic strain. A pilot-phenotyping experiment project revealed a high number of variations among B6.PWD consomics...
  88. pmc Strain background effects and genetic modifiers of hearing in mice
    Kenneth R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Brain Res 1091:79-88. 2006
    ..Because modifier genes and digenic inheritance are not always distinguishable, we also include in this review several examples of digenic inheritance of hearing loss that have been reported in both mice and humans...
  89. ncbi H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice
    R Merino
    Department of Pathology, University of Geneva, Switzerland
    Eur J Immunol 22:295-9. 1992
    ....
  90. ncbi Autism-like behavioral phenotypes in BTBR T+tf/J mice
    H G McFarlane
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730, USA
    Genes Brain Behav 7:152-63. 2008
    ....
  91. ncbi Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis
    A Fortin
    Emerillon Therapeutics, Montreal, Canada
    Annu Rev Genomics Hum Genet 8:163-92. 2007
    ..tuberculosis will help to define the key molecules involved in host antituberculous immunity and should provide new insights into this important infectious disease...
  92. ncbi Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion
    Isabelle Leclerc
    Henry Wellcome Laboratories for Integrated Signalling and Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD Bristol, UK
    Am J Physiol Endocrinol Metab 286:E1023-31. 2004
    ..The inhibitory effects of metformin on insulin secretion may therefore need to be considered with respect to the use of this drug for the treatment of type 2 diabetes...
  93. pmc A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans
    Cheryl D Chun
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e22. 2007
    ....
  94. pmc The contributions of normal variation and genetic background to mammalian gene expression
    Colin Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 7:R26. 2006
    ..Although potentially important, the relative contributions of genomic versus epigenetic and stochastic factors to variation in gene expression have not been quantified in mammalian species...
  95. ncbi Molecular characterization of the mouse agouti locus
    S J Bultman
    Biology Division, Oak Ridge National Laboratory, University of Tennessee School of Biomedical Sciences
    Cell 71:1195-204. 1992
    ....
  96. pmc MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
    Daniel Y Lee
    Sunnybrook Health Sciences Centre and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 104:20350-5. 2007
    ..Our results suggest that miR-378 transfection enhanced cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1...
  97. ncbi Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H547-59. 2006
    ....
  98. ncbi Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice
    Timothy S Fenske
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:5029-38. 2006
    ....
  99. ncbi Recombinant inbred strain panels: a tool for systems genetics
    Gary A Churchill
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Physiol Genomics 31:174-5. 2007
  100. ncbi Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
    Sarah J Collins
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Wash, USA
    Nephron Exp Nephrol 104:e23-34. 2006
    ..Although increased intrarenal expression of PAI-1 is also a feature of diabetic nephropathy, evidence that PAI-1 plays a primary pathogenetic role in the renal pathology is lacking...
  101. pmc Reduced receptor editing in lupus-prone MRL/lpr mice
    Jennifer L Lamoureux
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 204:2853-64. 2007
    ..Less efficient receptor editing could allow some autoreactive cells to escape from the bone marrow in lupus-prone mice, thus predisposing to autoimmunity...

Research Grants82

  1. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2010
    ..This animal studies project will generate interpretable and useful information relevant to public health issues like osteoporosis and skeletal fluorosis. ..
  2. MOLECULAR GENETICS OF LUNG TUMOR PROMOTION IN MICE
    Ming You; Fiscal Year: 2009
    ..The significance of these studies is that they will identify candidate pulmonary inflammation susceptibility genes that may also contribute to genetic susceptibility to lung cancer in humans. ..
  3. MOLECULAR GENETICS OF LUNG TUMOR PROMOTION IN MICE
    MING contact YOU; Fiscal Year: 2010
    ..The significance of these studies is that they will identify candidate pulmonary inflammation susceptibility genes that may also contribute to genetic susceptibility to lung cancer in humans. ..
  4. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
    ....
  5. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ....
  6. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
    ....
  7. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2010
    ....
  8. MECHANISMS OF MNU INDUCED LYMPHOMA IN AKR MICE
    Ellen Richie; Fiscal Year: 1992
    ..5.) To molecularly clone endogenous MuLV sequences that encode the gp70 subclass defined by specific aim #4 and develop constructs for future retroviral mediated gene transfer...
  9. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 1999
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  10. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  11. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2000
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  12. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2012
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  13. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2010
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  14. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2010
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  15. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ....
  16. Genetic Determinants of Physiological Responses to Fluoride in Bone
    ERIC EVERETT; Fiscal Year: 2009
    ..This animal studies project will generate interpretable and useful information relevant to public health issues like osteoporosis and skeletal fluorosis. ..
  17. Genetic Determinants of Physiological Responses to Fluoride in Bone
    ERIC EVERETT; Fiscal Year: 2009
    ..This animal studies project will generate interpretable and useful information relevant to public health issues like osteoporosis and skeletal fluorosis. ..
  18. TRANSGENICS AND GENETIC CONSTRUCTS SHARED RESOURCE
    Steven Fiering; Fiscal Year: 2009
    ..By partnering with JAX, the world's foremost facility for mouse genetics, and by expanding our services to include genetic construct production, karyotyping, and genotyping, we will better serve NCCC investigators. ..
  19. Genetic Predisposition for Intimal Hyperplasia in Mice
    Renee C LeBoeuf; Fiscal Year: 2010
    ..It is our goal to identify biomarkers to assess risk of developing IH and molecular mediators for the development of therapies to treat susceptible vessels. This will be done using genetic approaches. ..
  20. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2007
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
  21. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2006
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
  22. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2004
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. ..
  23. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2005
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. ..
  24. BIOPHYSICAL STUDY OF ANTIPSYCHOTICS BEHAVIORAL EFFECTS
    Stephen Fowler; Fiscal Year: 2003
    ....
  25. BIOPHYSICAL STUDY OF ANTIPSYCHOTICS BEHAVIORAL EFFECTS
    Stephen Fowler; Fiscal Year: 2000
    ....
  26. BIOPHYSICAL STUDY OF ANTIPSYCHOTICS BEHAVIORAL EFFECTS
    Stephen Fowler; Fiscal Year: 2002
    ....
  27. BIOPHYSICAL STUDY OF ANTIPSYCHOTICS BEHAVIORAL EFFECTS
    Stephen Fowler; Fiscal Year: 2001
    ....
  28. GENETICS OF SUSCEPTIBILITY TO SKIN TUMOR PROMOTION
    John DiGiovanni; Fiscal Year: 1990
    ....
  29. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2009
    ..It will also be a potential target for drug discovery and pharmacological intervention in hyperlipidemic patients in the general population. ..
  30. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2007
    ..It will also be a potential target for drug discovery and pharmacological intervention in hyperlipidemic patients in the general population. [unreadable] [unreadable] [unreadable]..
  31. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2005
    ..It will also be a potential target for drug discovery and pharmacological intervention in hyperlipidemic patients in the general population. ..
  32. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2006
    ..It will also be a potential target for drug discovery and pharmacological intervention in hyperlipidemic patients in the general population. [unreadable] [unreadable] [unreadable]..
  33. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2001
    ..Further, targeting this pool by either understanding its fine specificity or the requirements for Th development can overcome genetic tendencies and provide protection from otherwise fatal infection. ..
  34. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1999
    ..Further, targeting this pool by either understanding its fine specificity or the requirements for Th development can overcome genetic tendencies and provide protection from otherwise fatal infection. ..
  35. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2000
    ..Further, targeting this pool by either understanding its fine specificity or the requirements for Th development can overcome genetic tendencies and provide protection from otherwise fatal infection. ..
  36. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2002
    ..Further, targeting this pool by either understanding its fine specificity or the requirements for Th development can overcome genetic tendencies and provide protection from otherwise fatal infection. ..
  37. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1992
    ..These studies should provide important insights towards the understanding of Th1 and Th2 cell subset maturation and the characteristics of critical parasite antigens involved in this process...
  38. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1993
    ..These studies should provide important insights towards the understanding of Th1 and Th2 cell subset maturation and the characteristics of critical parasite antigens involved in this process...
  39. Axons and the extracellular matrix in spinal cord injury
    LYN JAKEMAN; Fiscal Year: 2006
    ..abstract_text> ..
  40. Axons and the extracellular matrix in spinal cord injury
    LYN JAKEMAN; Fiscal Year: 2007
    ..abstract_text> ..
  41. GENETIC AND DYNAMIC ANALYSES OF PEAK BONE DENSITY
    Wesley Beamer; Fiscal Year: 1999
    ..Ultimately, the applicants propose to correlate the phenotypic modeling mechanisms disclosed by their dynamic studies of bone modeling with the genes mapped in the first Aim. ..
  42. Axons and the extracellular matrix in spinal cord injury
    LYN JAKEMAN; Fiscal Year: 2005
    ..abstract_text> ..
  43. GENETIC AND DYNAMIC ANALYSES OF PEAK BONE DENSITY
    Wesley Beamer; Fiscal Year: 1999
    ..Ultimately, the applicants propose to correlate the phenotypic modeling mechanisms disclosed by their dynamic studies of bone modeling with the genes mapped in the first Aim. ..
  44. Axons and the extracellular matrix in spinal cord injury
    LYN JAKEMAN; Fiscal Year: 2004
    ..abstract_text> ..
  45. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2003
    ..abstract_text> ..
  46. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..abstract_text> ..
  47. GENETIC LINKAGE OF AUDITORY GATING
    Karen Stevens; Fiscal Year: 2000
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
  48. GENETIC LINKAGE OF AUDITORY GATING
    Karen Stevens; Fiscal Year: 1999
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
  49. GENETIC LINKAGE OF AUDITORY GATING
    Karen Stevens; Fiscal Year: 2001
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
  50. MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH
    PAULA SCHAUWECKER; Fiscal Year: 2004
    ..Results gleaned from these studies will facilitate our understanding of the biological mechanisms that underlie neuronal sensitivity and provide information regarding the pathogenesis of human epilepsy. ..
  51. MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH
    PAULA SCHAUWECKER; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  52. MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH
    PAULA SCHAUWECKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH
    PAULA SCHAUWECKER; Fiscal Year: 2005
    ..Results gleaned from these studies will facilitate our understanding of the biological mechanisms that underlie neuronal sensitivity and provide information regarding the pathogenesis of human epilepsy. ..
  54. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2001
    ..A BAC contig containing the critical interval will be analyzed and transcripts identified. Allelic variants for the candidate gene will be identified and tested for their functional significance. ..
  55. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2002
    ..A BAC contig containing the critical interval will be analyzed and transcripts identified. Allelic variants for the candidate gene will be identified and tested for their functional significance. ..
  56. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2000
    ..A BAC contig containing the critical interval will be analyzed and transcripts identified. Allelic variants for the candidate gene will be identified and tested for their functional significance. ..
  57. GLYCOLIPID CELL MEMBRANE ANTIGENS
    Donald Marcus; Fiscal Year: 1992
    ..The aim of this project is to identify the abnormality in glycosylation that we believe is the primary defect that underlies the In(Lu) phenotype...
  58. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2006
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. [unreadable] [unreadable]..
  59. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2005
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. ..
  60. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2004
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. ..
  61. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2006
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. [unreadable] [unreadable]..
  62. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2003
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. ..
  63. Genetic Basis for susceptibility to Experimental Autoimmune Encephalomyelitis
    Vijay Kuchroo; Fiscal Year: 2007
    ..abstract_text> ..
  64. Genetic Basis for susceptibility to EAE
    Vijay Kuchroo; Fiscal Year: 2005
    ..abstract_text> ..
  65. Genetic Basis for susceptibility to EAE.
    Vijay Kuchroo; Fiscal Year: 2006
    ..abstract_text> ..
  66. Genetics of susceptibility to candidiasis
    Scott Filler; Fiscal Year: 2009
    ....
  67. Genetic Mouse Models of Cartilage Healing
    Linda Sandell; Fiscal Year: 2009
    ..This could have a huge public health impact as the pain and disability from OA is estimated to effect 40 million people and cost 3 billion dollars per year in work loss and special care. ..
  68. Genetic and environmental modulation of RNA editing
    Claudia Schmauss; Fiscal Year: 2009
    ..abstract_text> ..
  69. Genetic and environmental modulation of RNA editing
    Claudia Schmauss; Fiscal Year: 2011
    ..abstract_text> ..
  70. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2001
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  71. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2002
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  72. Genetic Mouse Models of Cartilage Healing
    LINDA J contact SANDELL; Fiscal Year: 2010
    ..This could have a huge public health impact as the pain and disability from OA is estimated to effect 40 million people and cost 3 billion dollars per year in work loss and special care. ..
  73. Genetic and environmental modulation of RNA editing
    Claudia Schmauss; Fiscal Year: 2010
    ..abstract_text> ..
  74. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2000
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  75. Neurobiology of sociability in a mouse model system relevant to autism
    EDWARD BRODKIN; Fiscal Year: 2009
    ..By testing the relationships among social behavior and brain phenotypes relevant to autism, these studies may identify promising directions for future clinical and basic research on sociability impairments in autism. ..
  76. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2003
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  77. Neurobiology of sociability in a mouse model system relevant to autism
    EDWARD BRODKIN; Fiscal Year: 2007
    ..By testing the relationships among social behavior and brain phenotypes relevant to autism, these studies may identify promising directions for future clinical and basic research on sociability impairments in autism. ..
  78. Genetic Elements that Influence Susceptibility to CNS Autoimmunity
    ANA ANDERSON; Fiscal Year: 2007
    ..These studies will complement ongoing studies of the effects of Idd loci on the development of Type I diabetes in the NOD mouse and will accelerate the analysis of the genes affecting the development of CNS autoimmunity. ..