radiation chimera

Summary

Summary: An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.

Top Publications

  1. Kawamura T, Koka R, Ma A, Kumar V. Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction. J Immunol. 2003;171:5085-90 pubmed
    ..These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells...
  2. Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf H, et al. The adaptor molecule CARD9 is essential for tuberculosis control. J Exp Med. 2010;207:777-92 pubmed publisher
    ..Our data provide evidence that deregulated innate responses trigger excessive lung inflammation and demonstrate a pivotal role of CARD9 signaling in autonomous innate host defense against tuberculosis...
  3. Ajami B, Bennett J, Krieger C, Tetzlaff W, Rossi F. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007;10:1538-43 pubmed
  4. Pelus L, Fukuda S. Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. Leukemia. 2008;22:466-73 pubmed
    ..It remains to be determined if the chemokine mobilization axis can be harnessed to mobilize other populations of unique adult stem cells with clinical utility...
  5. Bezbradica J, Hill T, Stanic A, Van Kaer L, Joyce S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci U S A. 2005;102:5114-9 pubmed
  6. Allen C, Ansel K, Low C, Lesley R, Tamamura H, Fujii N, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004;5:943-52 pubmed
    ..In contrast, CXCR5 helped direct cells to the light zone and deficiency in CXCL13 was associated with aberrant light zone localization...
  7. John B, Crispe I. Passive and active mechanisms trap activated CD8+ T cells in the liver. J Immunol. 2004;172:5222-9 pubmed
  8. Gonzalez M, Quezada S, Blazar B, Panoskaltsis Mortari A, Rudensky A, Noelle R. The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. J Immunol. 2002;169:5581-9 pubmed
    ..These findings underscore the decisive effect of the inflammatory environment created by irradiation in determining the ultimate fate and function of alloreactive T cells in vivo..
  9. Ratajczak J, Reca R, Kucia M, Majka M, Allendorf D, Baran J, et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood. 2004;103:2071-8 pubmed
    ..The C3a-C3aR axis may prevent an uncontrolled release of HSPCs into peripheral blood. These data further suggest that the C3aR antagonist SB 290157 could be developed as a drug to mobilize HSPCs for transplantation...

More Information

Publications62

  1. Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, et al. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol. 2003;170:4649-55 pubmed
  2. Schaefer B, Schaefer M, Kappler J, Marrack P, Kedl R. Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo. Cell Immunol. 2001;214:110-22 pubmed
    ..Dendritic cells undergo specific morphologic changes following interactions with antigen-specific T cells...
  3. Burkett P, Koka R, Chien M, Chai S, Chan F, Ma A, et al. IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory. Proc Natl Acad Sci U S A. 2003;100:4724-9 pubmed
    ..These unexpected results provide insights into how IL-15R alpha supports memory CD8(+) T cells...
  4. Koka R, Burkett P, Chien M, Chai S, Chan F, Lodolce J, et al. Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice. J Exp Med. 2003;197:977-84 pubmed
    ..These findings demonstrate that NK cell-independent IL-15Ralpha expression is critical for maintaining peripheral NK cells, while IL-15Ralpha expression on NK cells is not required for this function...
  5. Savage A, Constantinides M, Bendelac A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol. 2011;186:5801-6 pubmed publisher
    ..Its expression may also enhance the survival of agonist-signaled thymocytes. ..
  6. Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic I, Socher I, et al. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood. 2010;116:841-9 pubmed publisher
  7. Takada M, Kitamura H, Koi T, Nakamura T, Fujitaka K. Measured proton sensitivities of bubble detectors. Radiat Prot Dosimetry. 2004;111:181-9 pubmed
    ..Bubbles were clearly formed by protons, but the proton sensitivities were one order of magnitude smaller than the neutron sensitivities. Thus, counts of protons can be ignored in neutron measurements in aircraft...
  8. Pajerowski A, Shapiro M, Gwin K, Sundsbak R, Nelson Holte M, MEDINA K, et al. Adult hematopoietic stem cells require NKAP for maintenance and survival. Blood. 2010;116:2684-93 pubmed publisher
    ..These data establish NKAP as one of a very small number of transcriptional regulators that is absolutely required for adult HSC maintenance and survival...
  9. Bannard O, Horton R, Allen C, An J, Nagasawa T, Cyster J. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013;39:912-24 pubmed publisher
    ..Finally, we identify a network of DZ CXCL12-expressing reticular cells that likely support DZ functions. ..
  10. Sanos S, Nowak J, Fallet M, Bajenoff M. Stromal cell networks regulate thymocyte migration and dendritic cell behavior in the thymus. J Immunol. 2011;186:2835-41 pubmed publisher
    ..These results highlight the central role of stromal microanatomy in orchestrating the multiple cellular interactions necessary for T cell migration/development within the thymus...
  11. Funk J, Gohlke J, Kraft A, McPherson C, Collins J, Jean Harry G. Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun. 2011;25:1063-77 pubmed publisher
    ..These data suggest a contributory role for IL-6 induced by exercise for neuroprotection in the CNS similar to that seen in the periphery...
  12. Yeghiazarians Y, Khan M, Angeli F, Zhang Y, Jahn S, Prasad M, et al. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. J Card Fail. 2010;16:669-78 pubmed publisher
    ..We first established the optimal and clinically applicable dosages of these drugs in mobilizing hematopoietic stem cells (HSC), and then tested the efficacy of monotherapy and combination therapy post-MI...
  13. Fock E, Yan F, Pan S, Chong B. NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo. Exp Hematol. 2008;36:78-92 pubmed
    ..By overexpressing the p45 subunit of NF-E2, we aim to increase the proportion of mature MKs and the potential for platelet production in vitro and in vivo...
  14. Katayama Y, Battista M, Kao W, Hidalgo A, Peired A, Thomas S, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell. 2006;124:407-21 pubmed
    ..Further, administration of a beta(2) adrenergic agonist enhances mobilization in both control and NE-deficient mice. Thus, these results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche...
  15. Baron R, Carvajal I, Fredenburgh L, Liu X, Porrata Y, Cullivan M, et al. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004;18:1276-8 pubmed
    ..This study demonstrates that expression of NOS2 in lung epithelial cells is critical for the development of lung injury and mediates surfactant dysfunction independent of NOS2 inflammatory cell expression and cytokine production...
  16. Boulianne B, Rojas O, Haddad D, Zaheen A, Kapelnikov A, Nguyen T, et al. AID and caspase 8 shape the germinal center response through apoptosis. J Immunol. 2013;191:5840-7 pubmed publisher
    ..In addition, we show that the deletion of caspase 8 specifically in murine GC-B cells results in larger GCs and a delay in affinity maturation, demonstrating the importance of apoptosis in GC homeostasis and clonal selection. ..
  17. Li X, Hu Z, Jorgenson M, Wingard J, Slayton W. Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation. Exp Hematol. 2008;36:1143-1156 pubmed publisher
    ..Bone marrow sinusoids remain predominantly host-derived following bone marrow transplantation. Systematic analysis was conducted at the cellular level to investigate how the host sinusoidal structures survived after lethal irradiation...
  18. Sharp P, Martin Ramirez J, Mangsbo S, Boross P, Pusey C, Touw I, et al. Fc?RIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis. J Immunol. 2013;190:340-8 pubmed publisher
    ..Where there was a lack of Fc?RIIb on circulating myeloid cells, expression of Fc?RIIb on intrinsic renal cells provided an additional level of protection from Ab-mediated glomerulonephritis...
  19. Wang C, Kenefeck R, Wardzinski L, Attridge K, Manzotti C, Schmidt E, et al. Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells. J Immunol. 2012;189:1118-22 pubmed publisher
    ..This observation provides a potential resolution to the above paradox and suggests CTLA-4 function on both Tconv and regulatory T cells can be achieved through cell-extrinsic mechanisms...
  20. Kuhn S, Hyde E, Yang J, Rich F, Harper J, Kirman J, et al. Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. J Immunol. 2013;191:1984-92 pubmed publisher
  21. Valaperti A, Nishii M, Liu Y, Naito K, Chan M, Zhang L, et al. Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production. Circulation. 2013;128:1542-54 pubmed publisher
    ..We sought to determine how IRAK4 modulates inflammation and outcome in a mouse model of viral myocarditis...
  22. Bell D, Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene. 2004;23:7290-6 pubmed
  23. Tamoutounour S, Guilliams M, Montanana Sanchis F, Liu H, Terhorst D, Malosse C, et al. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity. 2013;39:925-38 pubmed publisher
    ..Therefore, a high degree of functional specialization occurs among the mononuclear phagocytes of the skin. ..
  24. Galic S, Fullerton M, Schertzer J, Sikkema S, Marcinko K, Walkley C, et al. Hematopoietic AMPK ?1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest. 2011;121:4903-15 pubmed publisher
    ..Thus, activation of AMPK ?1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance...
  25. Chen Q, Snapper C. Inflammatory monocytes are critical for induction of a polysaccharide-specific antibody response to an intact bacterium. J Immunol. 2013;190:1048-55 pubmed publisher
    ..pneumoniae during the early phase of the response. These data are the first, to our knowledge, to establish a critical role for IM in the induction of an Ig response to an intact extracellular bacterium...
  26. Grisanti L, Gumpert A, Traynham C, Gorsky J, Repas A, Gao E, et al. Leukocyte-Expressed ?2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury. Circulation. 2016;134:153-67 pubmed publisher
    ..Immune cell-expressed ?2AR plays an essential role in regulating the early inflammatory repair response to acute myocardial injury by facilitating cardiac leukocyte infiltration. ..
  27. Otero D, Rickert R. CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition. J Immunol. 2003;171:5921-30 pubmed
    ..Thus, in addition to promoting mature B cell homeostasis and Ag-induced responses, the early onset of CD19 expression acts to enhance B cell generation...
  28. Kawai T, Choi U, Cardwell L, DeRavin S, Naumann N, Whiting Theobald N, et al. WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4. Blood. 2007;109:78-84 pubmed
    ..We conclude that increased apoptosis of mature myeloid cells in WHIM is secondary to a failure of marrow release and progression to normal myeloid cell senescence, and not a direct effect of activation of mutated CXCR4...
  29. Tan B, Lee M, Ruan R. Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity. J Comp Neurol. 2008;509:167-79 pubmed publisher
  30. Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh G, et al. Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation. 2012;126:2236-47 pubmed publisher
    ..Recent studies suggest that ROCK1 in macrophages and bone marrow-derived cells mediates atherogenesis. However, a similar role for ROCK2 in the pathogenesis of atherosclerosis has not been determined...
  31. Verykokakis M, Krishnamoorthy V, Iavarone A, Lasorella A, Sigvardsson M, Kee B. Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. J Immunol. 2013;191:5973-83 pubmed publisher
    ..Therefore, iNKT cells show both adaptive and innate-like requirements for ID proteins at distinct checkpoints during iNKT cell development. ..
  32. Ii M, Nishimura H, Iwakura A, Wecker A, Eaton E, Asahara T, et al. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation. 2005;111:1114-20 pubmed
    ..The possibility that EPCs could act as reservoirs of cytokines has been implied by several observations; however, a specific role for cytokine delivery has not been identified...
  33. Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M. TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J Immunol. 2013;190:1447-56 pubmed publisher
    ..Thus, TLR9 has paradoxical roles in regulating anti-DNA B cells: it helps purge the peripheral repertoire of autoreactive cells, yet is also required for their activation...
  34. Gounaris E, Erdman S, Restaino C, Gurish M, Friend D, Gounari F, et al. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007;104:19977-82 pubmed
    ..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention...
  35. Janot L, Sirard J, Secher T, Noulin N, Fick L, Akira S, et al. Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin. Eur J Immunol. 2009;39:1587-96 pubmed publisher
    ..We suggest that the radioresistant lung epithelial cells are essential for initiating early, TLR5-dependent signalling in response to flagellin and thus triggering the lung's innate immune responses...
  36. Hall S, Lau K, Chen S, Felt J, Gridley D, Yee J, et al. An improved mouse Sca-1+ cell-based bone marrow transplantation model for use in gene- and cell-based therapeutic studies. Acta Haematol. 2007;117:24-33 pubmed
    ..In summary, this murine Sca-1+ cell-based strategy could be used in studies of HSC-based gene or cell therapies...
  37. Wang Y, Cella M, Gilfillan S, Colonna M. Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells. J Immunol. 2010;184:2751-5 pubmed publisher
    ..We conclude that MDA5 and TLR3 mediate substantially distinct yet complementary functions during poly I:C-mediated activation of Ag-specific CD8 T cell responses...
  38. Wang C, Ciliberti N, Li S, Szmitko P, Weisel R, Fedak P, et al. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy. Circulation. 2004;109:1392-400 pubmed
    ..It is unknown whether PPAR-gamma agonists favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote endothelial lineage differentiation and early reendothelialization after vascular intervention...
  39. Mitchell J, Fitzgerald K, Coyle A, Silverman N, Cartwright N. TOLLing away in Brazil. Nat Immunol. 2006;7:675-9 pubmed
  40. Wysoczynski M, Reca R, Lee H, Wu W, Ratajczak J, Ratajczak M. Defective engraftment of C3aR-/- hematopoietic stem progenitor cells shows a novel role of the C3a-C3aR axis in bone marrow homing. Leukemia. 2009;23:1455-61 pubmed publisher
  41. Despars G, O Neill H. A role for niches in the development of a multiplicity of dendritic cell subsets. Exp Hematol. 2004;32:235-43 pubmed
    ..Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations...
  42. Klein I, Crispe I. Complete differentiation of CD8+ T cells activated locally within the transplanted liver. J Exp Med. 2006;203:437-47 pubmed
    ..We conclude that local antigen presentation cannot explain liver tolerance. On the contrary, the liver may be an excellent priming site for naive CD8+ T cells...
  43. Kim T, Hanak M, Trampont P, Braciale T. Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells. J Clin Invest. 2015;125:3965-80 pubmed publisher
    ..Together, these findings offer insight into the mechanism of stress erythropoiesis and into disorders of erythrocyte generation associated with stress. ..
  44. Wang H, Lebert V, Hung C, Galles K, Saijo S, Lin X, et al. C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014;192:1107-1119 pubmed publisher
    ..Our work provides new insight into innate immune mechanisms that drive vaccine immunity and Th17 cells. ..
  45. LeibundGut Landmann S, Weidner K, Hilbi H, Oxenius A. Nonhematopoietic cells are key players in innate control of bacterial airway infection. J Immunol. 2011;186:3130-7 pubmed publisher
    ..These data add a new level of complexity to the coordination of the innate immune response to L. pneumophila and illustrate how the cross talk between leukocytes and nonhematopoietic cells contributes to efficient host protection...
  46. Rubio M, Saito T, Kattleman K, Zhao G, Buchli J, Sykes M. Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-. J Immunol. 2005;175:665-76 pubmed
    ..The pathways of donor marrow and tumor rejection lead to the development of tumor-specific cell-mediated cytotoxic responses that are not due to bystander killing by alloreactive T cells...
  47. Boisset J, Robin C. [Endothelial origin for hematopoietic stem cells: a visual proof]. Med Sci (Paris). 2011;27:875-81 pubmed publisher
    ..Here, we summarize and discuss the different theories in light of the recent articles, especially those using in vivo confocal microscopy technology...
  48. Hochmeister S, Zeitelhofer M, Bauer J, Nicolussi E, Fischer M, Heinke B, et al. After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream. Am J Pathol. 2008;173:1669-81 pubmed publisher
    ..Moreover, we also found these cells in both mesenteric lymph nodes and spleens. Hence, microglia- and bone marrow-derived DCs can leave the CNS via the blood stream...
  49. Fehr T, Wang S, Haspot F, Kurtz J, Blaha P, Hogan T, et al. Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol. 2008;181:4371-80 pubmed
    ..Thus, BM-derived B cells are potent tolerogenic APCs for alloreactive CD8 cells...
  50. Ferrer I, Liu D, Pinelli D, Koehn B, Stempora L, Ford M. CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules. J Immunol. 2012;189:4387-95 pubmed publisher
    ..We conclude that therapies designed to target inflammatory cytokines during donor-reactive T cell activation may be beneficial in attenuating these responses and prolonging graft survival...
  51. Ieronimakis N, Hays A, Reyes M. Bone marrow-derived cells do not engraft into skeletal muscle microvasculature but promote angiogenesis after acute injury. Exp Hematol. 2012;40:238-249.e3 pubmed publisher
    ..Therefore, despite the absence of BM engraftment to regenerated skeletal muscle microvasculature, macrophages recruited after injury promote angiogenesis and, in turn, vascular regeneration...
  52. Bauer E, Chanthaphavong R, Sodhi C, Hackam D, Billiar T, Bauer P. Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension. Circ Res. 2014;114:1596-600 pubmed publisher
    ..Recent studies demonstrate a role for toll-like receptor 4 (TLR4) in the pathogenesis of pulmonary hypertension (PH); however, the cell types involved in mediating the effects of TLR4 remain unknown...
  53. Pelletier A, Guimont Desrochers F, Ashton M, Brodnicki T, Lesage S. The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7. J Immunol. 2012;188:5561-70 pubmed publisher
    ..Our findings highlight the multigenic regulation of the size of the pDC compartment and will facilitate the identification of genes linked to this trait...