transplantation chimera

Summary

Summary: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.

Top Publications

  1. Buckley R, Win C, Moser B, Parrott R, Sajaroff E, Sarzotti Kelsoe M. Post-transplantation B cell function in different molecular types of SCID. J Clin Immunol. 2013;33:96-110 pubmed publisher
    ..However, the development of B cell function has been more problematic. We report here results of analyses of B cell function in 125 SCID recipients prior to and long-term after non-ablative BMT, according to their molecular type...
  2. Al Adra D, Pawlick R, Shapiro A, Anderson C. Targeting cells causing split tolerance allows fully allogeneic islet survival with minimal conditioning in NOD mixed chimeras. Am J Transplant. 2012;12:3235-45 pubmed publisher
    ..Furthermore, these chimeric NOD mice are immunocompetent, diabetes free and accept donor islet allografts...
  3. Haddad E, Leroy S, Buckley R. B-cell reconstitution for SCID: should a conditioning regimen be used in SCID treatment?. J Allergy Clin Immunol. 2013;131:994-1000 pubmed publisher
  4. Scandling J, Busque S, Dejbakhsh Jones S, Benike C, Sarwal M, Millan M, et al. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant. 2012;12:1133-45 pubmed publisher
    ..All 16 patients had excellent graft function at the last observation point with or without maintenance drugs...
  5. Teigland C, Parrott R, Buckley R. Long-term outcome of non-ablative booster BMT in patients with SCID. Bone Marrow Transplant. 2013;48:1050-5 pubmed publisher
    ..A majority of the patients alive today have normal or adequate T-cell function and are healthy. Nonablative booster BMT can be lifesaving for SCID. ..
  6. Jacewicz R, Lewandowski K, Rupa Matysek J, Jedrzejczyk M, Brzezinski P, Dobosz T, et al. Donor-derived DNA in hair follicles of recipients after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2010;45:1638-44 pubmed publisher
    ..Our results proved the existence of donor-derived stem DNA in the recipients' hair follicle cells. This report undermines the validity of data indicating that hair follicle cells maintain 100% of recipient origin...
  7. Zhu Z, Fan L, Wang Q. Simultaneous blockade of costimulatory signals CD28-CD80 and CD40-CD154 combined with monoclonal antibody against CD25 induced a stable chimerism and tolerance without graft-versus-host disease in rat. Eur Surg Res. 2011;46:109-17 pubmed publisher
    ..Our aim was to explore a nontoxic strategy for the induction of mixed chimerism by pretreatment with anti-CD25 monoclonal antibody (mAb), cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (CTLA4Ig) and anti-CD154 mAb...
  8. Bozulic L, Wen Y, Xu H, Ildstad S. Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants. Transplantation. 2011;91:908-15 pubmed publisher
    ..In this study, we evaluated the role of Treg in peripheral tolerance to composite tissue allografts (CTA)...
  9. Ikeguchi R, Sacks J, Unadkat J, Solari M, Horibe E, Thomson A, et al. Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression. Transplantation. 2008;85:237-46 pubmed publisher
    ..Since indefinite graft survival was not achieved, we have further modified the DC by pharmacologic (rapamycin; Rapa) conditioning and ascertained their influence on graft survival, without continued immunosuppressive therapy...

More Information

Publications62

  1. Gutman J, Turtle C, Manley T, Heimfeld S, Bernstein I, Riddell S, et al. Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood. 2010;115:757-65 pubmed publisher
    ..Future investigations based on these findings may result in strategies to predict a dominant unit and enhance graft-versus-leukemia effect...
  2. Li Z, Benghiat F, Charbonnier L, Kubjak C, Rivas M, Cobbold S, et al. CD8+ T-Cell depletion and rapamycin synergize with combined coreceptor/stimulation blockade to induce robust limb allograft tolerance in mice. Am J Transplant. 2008;8:2527-36 pubmed publisher
  3. Starzl T. Immunosuppressive therapy and tolerance of organ allografts. N Engl J Med. 2008;358:407-11 pubmed publisher
  4. Czechowicz A, Kraft D, Weissman I, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 2007;318:1296-9 pubmed
    ..Subsequent transplantation of these mice with donor HSCs led to chimerism levels of up to 90%. Extrapolation of these methods to humans may enable mild but effective conditioning regimens for transplantation...
  5. Bröcker V, Lehmann U, Langer F, Fellous T, Mengel M, Brittan M, et al. [Fibroblasts of recipient origin contribute to broncholitis obliterans in human lung transplants]. Verh Dtsch Ges Pathol. 2006;90:277-85 pubmed
    ..The participation of circulating precursor cells in the development of experimental pulmonary fibrosing lesions in mice has been recently demonstrated...
  6. Kristt D, Stein J, Yaniv I, Klein T. Assessing quantitative chimerism longitudinally: technical considerations, clinical applications and routine feasibility. Bone Marrow Transplant. 2007;39:255-68 pubmed
    ..This information also provides unique insights into the biological dynamics of engraftment underlying the fluctuations in the temporal course of a patient's chimeric status...
  7. Zhang C, Lou J, Li N, Todorov I, Lin C, Cao Y, et al. Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody. J Immunol. 2007;178:838-50 pubmed
    ..These results indicate that anti-CD3 conditioning separates GVL activity from GVHD via confining donor CD8(+) T cell expansion to host lymphohemological tissues as well as tolerizing them in the host...
  8. Ballen K, Spitzer T, Yeap B, McAfee S, Dey B, Attar E, et al. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant. 2007;13:82-9 pubmed
    ..Our findings indicate that adult patients can tolerate double UBC transplantation well and achieve sustained antitumor responses using this reduced-intensity conditioning regimen...
  9. Rahhal D, Xu H, Huang W, Wu S, Wen Y, Huang Y, et al. Dissociation between peripheral blood chimerism and tolerance to hindlimb composite tissue transplants: preferential localization of chimerism in donor bone. Transplantation. 2009;88:773-81 pubmed publisher
    ..Mixed chimerism induces donor-specific tolerance to composite tissue allotransplants (CTAs). In the present studies, we used a nonmyeloablative conditioning approach to establish chimerism and promote CTA acceptance...
  10. Yu P, Xiong S, He Q, Chu Y, Lu C, Ramlogan C, et al. Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts. Immunology. 2009;127:500-11 pubmed publisher
  11. Burroughs L, Storb R, Leisenring W, Pulsipher M, Loken M, Torgerson T, et al. Intensive postgrafting immune suppression combined with nonmyeloablative conditioning for transplantation of HLA-identical hematopoietic cell grafts: results of a pilot study for treatment of primary immunodeficiency disorders. Bone Marrow Transplant. 2007;40:633-42 pubmed
    ..However, there was a risk of GVHD, which is an undesirable outcome for this group of patients...
  12. Pan H, Zhao K, Wang L, Zheng Y, Zhang G, Mai H, et al. Mesenchymal stem cells enhance the induction of mixed chimerism and tolerance to rat hind-limb allografts after bone marrow transplantation. J Surg Res. 2010;160:315-24 pubmed publisher
  13. Scandling J, Busque S, Dejbakhsh Jones S, Benike C, Millan M, Shizuru J, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med. 2008;358:362-8 pubmed publisher
    ..Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease...
  14. Haspel R, Kao G, Yeap B, Cutler C, Soiffer R, Alyea E, et al. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant. 2008;41:523-9 pubmed
  15. Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360:692-8 pubmed publisher
    ..The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection...
  16. Chan W, Razavy H, Luo B, Shapiro A, Anderson C. Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras. J Immunol. 2008;180:5177-86 pubmed
    ..In contrast, the possibility of humoral tolerance to multiple donors is potentially beneficial...
  17. Huang W, Lin J, Wallace C, Chuang W, Wei F, Liao S. Vascularized bone grafts within composite tissue allotransplants can autocreate tolerance through mixed chimerism with partial myeloablative conditioning: an experimental study in rats. Plast Reconstr Surg. 2010;125:1095-103 pubmed publisher
    ..g., hand/forearm composite tissue allotransplants). The authors investigated the role of the vascularized bone graft within the hind-limb osteomyocutaneous flap in inducing tolerance...
  18. Li S, Salgar S, Kurimoto Y, Yousem S, Pham S. Mixed chimerism achieved by a nonlethal conditioning regimen induces donor-specific tolerance to lung allografts. J Surg Res. 2008;146:289-97 pubmed publisher
    ..The aim of this study was to develop a nonlethal conditioning regimen to induce tolerance to lung allografts...
  19. Hong Y, Liu H, Chen P, Chen Y, Lyou J, Hu H, et al. Hair follicle: a reliable source of recipient origin after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;40:871-4 pubmed
  20. Alexander S, Smith N, Hu M, Verran D, Shun A, Dorney S, et al. Chimerism and tolerance in a recipient of a deceased-donor liver transplant. N Engl J Med. 2008;358:369-74 pubmed publisher
    ..The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy...
  21. Kawai T, Cosimi A, Spitzer T, Tolkoff Rubin N, Suthanthiran M, Saidman S, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008;358:353-61 pubmed publisher
  22. Straathof K, Rao K, Eyrich M, Hale G, Bird P, Berrie E, et al. Haemopoietic stem-cell transplantation with antibody-based minimal-intensity conditioning: a phase 1/2 study. Lancet. 2009;374:912-20 pubmed publisher
    ..We tested a novel antibody-based minimal-intensity conditioning (MIC) regimen to assess whether this approach allowed curative donor stem-cell engraftment without non-haemopoietic toxicity...
  23. Zhang C, Todorov I, Lin C, Atkinson M, Kandeel F, Forman S, et al. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A. 2007;104:2337-42 pubmed
    ..Therefore, this radiation-free GVHD preventive approach for induction of chimerism may represent a viable means for reversing type 1 diabetes...
  24. Ophir E, Or Geva N, Gurevich I, Tal O, Eidelstein Y, Shezen E, et al. Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells. Blood. 2013;121:1220-8 pubmed publisher
    ..Thus, anti-third-party Tcms support TDBMT engraftment under reduced-conditioning through lymph-node sequestration and deletion of HADTCs, offering a novel and potentially safe approach for attaining stable hematopoietic chimerism...
  25. Strom S, Davila J, Grompe M. Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol. 2010;640:491-509 pubmed publisher
  26. Brehm M, Racki W, Leif J, Burzenski L, Hosur V, Wetmore A, et al. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood. 2012;119:2778-88 pubmed publisher
    ..These data provide a new immunodeficient mouse model that does not require irradiation preconditioning for human HSC engraftment and immune system development...
  27. Slack J, Dueck A, Fauble V, Sproat L, Reeder C, Noel P, et al. Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyt. Biol Blood Marrow Transplant. 2013;19:1167-74 pubmed publisher
    ..We conclude that FBM-A is an effective and safe conditioning regimen for adults up to age 69 with hematologic malignancies who have low-, intermediate-, or high-risk scores according to the DRI. ..
  28. Chen Y, Chang M, Chien C, Wu S, Yu C, Chen H. Contribution of mature hepatocytes to small hepatocyte-like progenitor cells in retrorsine-exposed rats with chimeric livers. Hepatology. 2013;57:1215-24 pubmed publisher
    ..Extensive elimination of oval cell response by repeated administration of 4,4'-methylenedianiline (DAPM) to retrorsine-exposed rats impaired the emergence of SHPC clusters...
  29. Graves S, Mathes D, Georges G, Kuhr C, Chang J, Butts T, et al. Long-term tolerance to kidney allografts after induced rejection of donor hematopoietic chimerism in a preclinical canine model. Transplantation. 2012;94:562-8 pubmed
    ..However, this procedure can result in graft-versus-host disease, thereby limiting its application. Here, we test the hypothesis that mixed chimerism can be intentionally reverted to host hematopoiesis without rejection of a kidney graft...
  30. Gungor T, Teira P, Slatter M, Stussi G, Stepensky P, Moshous D, et al. Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study. Lancet. 2014;383:436-48 pubmed publisher
    ..We examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients...
  31. Kawai T, Sachs D. Tolerance induction: hematopoietic chimerism. Curr Opin Organ Transplant. 2013;18:402-7 pubmed publisher
    ..In this review, recent progress in tolerance induction in preclinical (nonhuman primates) and clinical transplantation is summarized...
  32. Leonard D, Kurtz J, Cetrulo C. Vascularized composite allotransplantation: towards tolerance and the importance of skin-specific immunobiology. Curr Opin Organ Transplant. 2013;18:645-51 pubmed publisher
  33. Hoffmann J, Stabla K, Burchert A, Volkmann T, Bornhauser M, Thiede C, et al. Monitoring of acute myeloid leukemia patients after allogeneic stem cell transplantation employing semi-automated CD34+ donor cell chimerism analysis. Ann Hematol. 2014;93:279-85 pubmed publisher
    ..Here, we propose a novel semi-automated procedure for CD34+ DCC analysis after allogeneic SCT that is simple, reliable, and therefore applicable in all hematologic laboratories...
  34. Choi H, Geng Y, Cho H, Li S, Giri P, Felio K, et al. Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells. Blood. 2011;117:1880-7 pubmed publisher
    ..Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development...
  35. Graves S, Storer B, Butts T, Storb R. Comparing high and low total body irradiation dose rates for minimum-intensity conditioning of dogs for dog leukocyte antigen-identical bone marrow grafts. Biol Blood Marrow Transplant. 2013;19:1650-4 pubmed publisher
    ..TBI delivered at a high dose rate was well tolerated but was not associated with a better rate of allogeneic hematopoietic cell engraftment compared with TBI delivered at a lower dose rate. ..
  36. Corey D, Rosental B, Kowarsky M, Sinha R, Ishizuka K, Palmeri K, et al. Developmental cell death programs license cytotoxic cells to eliminate histocompatible partners. Proc Natl Acad Sci U S A. 2016;113:6520-5 pubmed publisher
  37. Lee S, Rigby R, Zotos D, Tsai L, Kawamoto S, Marshall J, et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J Exp Med. 2011;208:1377-88 pubmed publisher
    ..In conclusion, Bcl-6(+) T cells are necessary at B cell priming to form extrafollicular antibody responses, and these pre-GC Tfh cells can be distinguished phenotypically from GC Tfh cells...
  38. Ng C, Oldstone M. Infected CD8?- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection. Proc Natl Acad Sci U S A. 2012;109:14116-21 pubmed publisher
    ..Our findings further illuminate the contribution of DCs to the production of IL-10 and to viral persistence...
  39. Nakajima S, Ohashi J, Sawada A, Noda K, Fukumoto Y, Shimokawa H. Essential role of bone marrow for microvascular endothelial and metabolic functions in mice. Circ Res. 2012;111:87-96 pubmed publisher
    ..Recent studies have suggested the important role of the bone marrow (BM) in modulating cardiovascular and metabolic functions...
  40. Li S, Sun Z, Brunt K, Shi X, Chen M, Weisel R, et al. Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrow-derived progenitor cells and prevents cardiac dysfunction after a myocardial infarction. Eur Heart J. 2013;34:1157-67 pubmed publisher
    ..In aged individuals, these cells are diminished and dysfunctional. We evaluated the derivation of some of these cardiac progenitors and a method to restore their number and function...
  41. Colacios C, Casemayou A, Dejean A, Gaits Iacovoni F, Pedros C, Bernard I, et al. The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development. J Exp Med. 2011;208:2183-91 pubmed publisher
    ..Together, our data reveal a key role for Vav1-dependent T cell antigen receptor signaling in natural T(reg) cell development...
  42. Solem R, Eames B, Tokita M, Schneider R. Mesenchymal and mechanical mechanisms of secondary cartilage induction. Dev Biol. 2011;356:28-39 pubmed publisher
  43. Rezaee F, Peppelenbosch M, Dashty M. Donor chimera model for tolerance induction in transplantation. Hum Immunol. 2013;74:550-6 pubmed publisher
    ..This article introduces the 'donor chimera model' via the concept of the 'closed transplantation loop' approach for tolerance induction which seeks to limit the use of immunosuppressive therapy after transplantation...
  44. Pessac B, Nimmagadda V, Makar T, Fishman P, Bever C, Trisler D. Adult hematopoietic progenitors are multipotent in chimeric mice. C R Biol. 2012;335:454-62 pubmed publisher
    ..Thus, adult mammals carry cells that appear to exhibit a developmental potential reminiscent of ESCs and iPSCs suggesting they could be used for cell replacement therapy...
  45. Fitzhugh C, Weitzel R, Hsieh M, Phang O, Madison C, Luznik L, et al. Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model. Bone Marrow Transplant. 2013;48:1335-41 pubmed publisher
    ..These data identify a novel strategy for inducing mixed chimerism for the treatment of nonmalignant hematologic diseases. ..
  46. Feng Y, Zhang X, Chen G, Xu Y, Gong F, Zhu Z, et al. [Quantitative monitoring of multi-donor chimerism after multi-donor allogeneic hematopoietic stem cell transplantation]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013;21:436-40 pubmed publisher
    ..Compared to the D alleles, R alleles show more strategic importance because it can lead to more accurate result and allowed simplifying the arithmetic calculations for DD-CHM(%)...
  47. Lion T, Watzinger F, Preuner S, Kreyenberg H, Tilanus M, de Weger R, et al. The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation. Leukemia. 2012;26:1821-8 pubmed publisher
    ..Wide use of the European-harmonized protocol for chimerism analysis presented will provide a basis for optimal diagnostic support and timely treatment decisions...
  48. Cekic C, Sag D, Li Y, Theodorescu D, Strieter R, Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors. J Immunol. 2012;188:198-205 pubmed publisher
    ..The data suggest that blockade of A(2B)ARs enhances DC activation and CXCR3-dependent antitumor responses...
  49. Otsuru S, Rasini V, Bussolari R, Hofmann T, Dominici M, Horwitz E. Cytokine-induced osteopoietic differentiation of transplanted marrow cells. Blood. 2011;118:2358-61 pubmed publisher
    ..Post-BMT cytokine therapy may generate durable osteopoietic engraftment, which should lead to sustained clinical benefit and render BMT more applicable to bone disorders...
  50. Jaiswal S, Chakrabarti A, Chatterjee S, Bhargava S, Ray K, Chakrabarti S. Hemophagocytic syndrome following haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide. Int J Hematol. 2016;103:234-42 pubmed publisher
    ..Considering the fact that post-transplant HPS is usually a refractory and fatal condition, we discuss further attempts at deciphering the pathogenesis, developing modalities to prevent this complication and improve the outcome. ..
  51. Masaki H, Nakauchi H. Interspecies chimeras for human stem cell research. Development. 2017;144:2544-2547 pubmed publisher
  52. Chen Z, Jalabi W, Shpargel K, Farabaugh K, Dutta R, Yin X, et al. Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci. 2012;32:11706-15 pubmed publisher
    ..The therapeutic significance of these findings rests not only in identifying neuroprotective functions of microglia, but also in establishing the CNS location of TLR4 activation...
  53. Irish W, Arcona S, Gifford R, Baillie G, Cooper M. Enteric-coated mycophenolate sodium versus mycophenolate mofetil maintenance immunosuppression: outcomes analysis of the United Network for Organ Sharing/Organ Procurement and Transplantation Network database. Transplantation. 2010;90:23-30 pubmed publisher