Summary: Derivatives of UREA where one of the amino groups is replaced with hydrazine.

Top Publications

  1. Cooper K, Kennedy D. Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking. Food Addit Contam. 2007;24:935-42 pubmed
    ..Metabolite stock and working standard solutions in methanol were also stable for 10 months at 4 degrees C. Only a 10 ng ml(-1) solution of SEM showed a small drop in concentration over this extended storage period. ..
  2. Jain J, Kumar Y, Stables J, Sinha R. Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents. Med Chem. 2010;6:44-50 pubmed
    ..These compounds were found to elevate gamma-amino butyric acid (GABA) levels in the midbrain region, thus indicating that (+/-) 3-menthone semicarbazides could be considered as a lead molecule in designing of a potent anticonvulsant drug.
  3. Azam F, El Gnidi B, Alkskas I. Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides. Eur J Med Chem. 2010;45:2817-26 pubmed publisher
    A series of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides (3a-19a; 3b-6b) were synthesized in good yield and evaluated for their anticonvulsant and antioxidant activities...
  4. Siwek A, Stefanska J. Antimicrobial activity and SAR study of some novel thiosemicarbazide derivatives bearing piperidine moiety. Med Chem. 2011;7:690-6 pubmed
    ..The significant molecular descriptors related to the compounds with antifungal activity were: electrostatic potential surface, the highest occupied molecular orbital energy, surface area, volume, and hydration energy. ..
  5. Salgin Gökşen U, Gökhan Kelekçi N, Goktas O, Köysal Y, Kiliç E, Isik S, et al. 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti-inflammatory and antimicrobial activities. Bioorg Med Chem. 2007;15:5738-51 pubmed
    ..While most compounds were exhibiting high activity in the analgesic-anti-inflammatory field, most of them were found to be inactive against bacteria and fungi. ..
  6. Azam F, Alkskas I, Khokra S, Prakash O. Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants. Eur J Med Chem. 2009;44:203-11 pubmed publisher
    A series of N(4)-(naphtha[1,2-d]thiazol-2-yl)semicarbazides were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p...
  7. Siwek A, Staczek P, Wujec M, Stefanska J, Kosikowska U, Malm A, et al. Biological and docking studies of topoisomerase IV inhibition by thiosemicarbazides. J Mol Model. 2011;17:2297-303 pubmed publisher
    ..The difference in activity against type IIA topoisomerases between (1) and (2) was further investigated by docking studies, which suggested that these compounds target the ATP binding pocket. ..
  8. Siwek A, Staczek P, Stefanska J. Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides. Eur J Med Chem. 2011;46:5717-26 pubmed publisher
  9. Delatour T, Gremaud E, Mottier P, Richoz J, Arce Vera F, Stadler R. Preparation of stable isotope-labeled 2-nitrobenzaldehyde derivatives of four metabolites of nitrofuran antibiotics and their comprehensive characterization by UV, MS, and NMR techniques. J Agric Food Chem. 2003;51:6371-9 pubmed
    ..A major advantage of the described procedure is that it can be extended to the preparation of other carbon-13-labeled derivatives of metabolites of nitrofuran antibiotics. ..

More Information

Publications111 found, 100 shown here

  1. Singh S, Husain K, Athar F, Azam A. Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives. Eur J Pharm Sci. 2005;25:255-62 pubmed
    ..81microM of 11, IC50=0.84 microM of 17 versus IC50=1.81microM of metronidazole). The study suggests the possibility of developing triazine analogues as potential drug candidates for antiamoebic activity. ..
  2. Roy K, Basu S, Ramaswami A, Nayak D, Lahiri S. Incorporation of thiosemicarbazide in Amberlite IRC-50 for separation of astatine from alpha-irradiated bismuth oxide. Appl Radiat Isot. 2004;60:793-9 pubmed
    ..The resin showed high selectivity for astatine. The adsorbed astatine was recovered using 0.1M EDTA at pH approximately 10...
  3. Coffinier Y, Szunerits S, Jama C, Desmet R, Melnyk O, Marcus B, et al. Peptide immobilization on amine-terminated boron-doped diamond surfaces. Langmuir. 2007;23:4494-7 pubmed
    ..The resulting surfaces were characterized using X-ray photoelectron spectroscopy (XPS) and fluorescence measurements. ..
  4. Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A. A ninety-day toxicity study of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol. 2009;47:2490-8 pubmed publisher
  5. Nugiel D, Vidwans A, Dzierba C. Parallel synthesis of acylsemicarbazide libraries: preparation of potent cyclin dependent kinase (cdk) inhibitors. Bioorg Med Chem Lett. 2004;14:5489-91 pubmed
    ..Several compounds were active against cdk4/D1 and cdk2/E in the low nanomolar range. The SAR indicates a wide variety of substituents are tolerated at the acylsemicarbazide moiety. ..
  6. Anirudhan T, Jalajamony S. Ethyl thiosemicarbazide intercalated organophilic calcined hydrotalcite as a potential sorbent for the removal of uranium(VI) and thorium(IV) ions from aqueous solutions. J Environ Sci (China). 2013;25:717-25 pubmed
    ..The adsorbent can be regenerated effectively from U(VI) and Th(IV) loaded ones using 0.01 mol/L HCl. The new adsorbent was quite stable for many cycles, without much reduction in its adsorption capacity towards the metals. ..
  7. Li M, Zhang Z, Li R, Wang J, Ali A. Removal of Pb(II) and Cd(II) ions from aqueous solution by thiosemicarbazide modified chitosan. Int J Biol Macromol. 2016;86:876-84 pubmed publisher
    ..The metal ions adsorption mechanism was concluded to be mainly dominated by complexation reaction process. The desorption study indicated that the target adsorbent was easy to be regenerated. ..
  8. Chowdhury S, Davis R. Influence of dietary osteolathyrogens on the ultrastructure of shell and membranes of eggs from laying hens. Br Poult Sci. 1995;36:575-83 pubmed
    ..3. Establishment between shell and membranes is reduced. Within the cone layer both type A and type B mammillary bodies occur. Large interstitial spaces and late fusion of the palisade layer indicate reduced resistance to fracture. ..
  9. Nguelefack T, Nana P, Atsamo A, Dimo T, Watcho P, Dongmo A, et al. Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). J Ethnopharmacol. 2006;106:70-5 pubmed
    ..The extract protected 20% of animals against death in seizures induced by TSC and STN. These results suggest a peripheral and central analgesic activities as well as an anticonvulsant effect of the leaves of Kalanchoe crenata...
  10. Maia P, Nguyen H, Ponader D, Hagenbach A, Bergemann S, Gust R, et al. Neutral gold complexes with tridentate SNS thiosemicarbazide ligands. Inorg Chem. 2012;51:1604-13 pubmed publisher
    ..On the other hand, the reduction of Au(III) to Au(I) leads to a considerable decrease of the cytotoxicity. ..
  11. Qi B, Mi B, Zhai X, Xu Z, Zhang X, Tian Z, et al. Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors. Bioorg Med Chem. 2013;21:5246-60 pubmed publisher
    ..In this study, a promising compound 28 was identified, which displayed 2.1-, 3.3-, 48.4- and 3.6-fold increase against A549, HT-29, U87MG and NCI-H460 cell lines, respectively, compared with that of Foretinib. ..
  12. Omar A, Farghaly A, Hazzai A, Eshba N, Sharabi F, Daabees T. Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other pharmacological properties. J Pharm Sci. 1981;70:1075-9 pubmed
    ..The products showed no antileukemic activity in the P-388 lymphocytic leukemia system and did not exhibit any anticonvulsant or estrogenic properties. ..
  13. Di Costanzo L, Pique M, Christianson D. Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster. J Am Chem Soc. 2007;129:6388-9 pubmed
  14. Bourguet C, Sabatino D, Lubell W. Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides. Biopolymers. 2008;90:824-31 pubmed publisher
    ..A proof of concept for the use of benzophenone protection has been established by the synthesis of an aza-peptide analog of a potent activator of caspase 9 in cancer cells. ..
  15. Cwiek Ludwicka K. [Hazards for health related to migration of substances from packaging into food]. Rocz Panstw Zakl Hig. 2010;61:341-7 pubmed
  16. Pomarnacka E, Kozlarska Kedra I. Synthesis of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)semi-carbazides and their transformation into 4-chloro-2-mercapto-N-(4,5-dihydro-5-oxo-4-phenyl-1H-1,2,4-triazol-3-yl)benzenesulfonamides as potential anticancer and anti-HIV agents. Farmaco. 2003;58:423-9 pubmed
    Synthesis of a series of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)semicarbazides (6-16) and 4-chloro-2-mercapto-N-(4,5-dihydro-5-oxo-4-phenyl-1H-1,2,4-triazol-3-yl)benzenesulfonamides (17-22) were reported...
  17. Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, et al. Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties. J Med Chem. 2008;51:314-23 pubmed publisher
    ..In summary, the multifunctional prodrugs of tegafur display selectivity toward cancer cells, antiangiogenic activity and anticancer activities in vitro and in vivo, superior to those of tegafur. ..
  18. Cooper K, Le J, Kane C, Kennedy D. Kinetics of semicarbazide and nitrofurazone in chicken eggs and egg powders. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:684-92 pubmed publisher
    ..NFZ was detectable in whole eggs during ingestion of only 0.1% of the therapeutic NFZ dose, making detection of intact NFZ in eggs a feasible means to prove conclusively the administration of this banned compound. ..
  19. Maczyński M, Zimecki M, Taraszkiewicz M, Ryng S. Synthesis, immunological activity and computational study of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides. Acta Pol Pharm. 2008;65:543-9 pubmed
    A series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides (M1-M9) were obtained by reacting 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide with isocyanate and isothiocyanate...
  20. Cui F, Fan J, Li J, Hu Z. Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy. Bioorg Med Chem. 2004;12:151-7 pubmed
    ..A practical method was proposed for the determination of BCPT in human serum samples. ..
  21. Zanoveli J, Ferreira Netto C, Brandao M. Conditioned place aversion organized in the dorsal periaqueductal gray recruits the laterodorsal nucleus of the thalamus and the basolateral amygdala. Exp Neurol. 2007;208:127-36 pubmed
    ..From this evidence we suggest that a loop dPAG-LD-BLA-dPAG is activated during the panic disorder with agoraphobia. ..
  22. Riahi S, Ganjali M, Hariri M, Abdolahzadeh S, Norouzi P. Determination of the formation constant for the inclusion complex between Lanthanide ions and Dansyl chloride derivative by fluorescence spectroscopy: theoretical and experimental investigation. Spectrochim Acta A Mol Biomol Spectrosc. 2009;74:253-8 pubmed publisher
    ..It can be concluded that this derivative of Dansyl chloride with inherent high fluorescence intensity is a suitable reagent for the selective determination of the Er(3+) ion which can be used in constructing selective Er(3+) sensors. ..
  23. Miura M, Hori W, Kasahara Y, Nakagawa I. Quantitative assessment of the metabolic activation of alicyclic amines via aldehyde. J Pharmacol Toxicol Methods. 2010;61:44-51 pubmed publisher
    ..The post-incubation method is useful for screening newly synthesized compounds to quantitatively assess the bioactivation of aldehydes descending from alicyclic amines. ..
  24. Duburcq X, Olivier C, Desmet R, Halasa M, Carion O, Grandidier B, et al. Polypeptide semicarbazide glass slide microarrays: characterization and comparison with amine slides in serodetection studies. Bioconjug Chem. 2004;15:317-25 pubmed
  25. Becalski A, Lau B, Lewis D, Seaman S. Semicarbazide formation in azodicarbonamide-treated flour: a model study. J Agric Food Chem. 2004;52:5730-4 pubmed
    ..2 mg/kg. Similar levels of semicarbazide were found in the crusts of breads made from azodicarbonamide-treated flour. ..
  26. Yang S, Lee S, Kwak H, Gong Y. Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate. J Org Chem. 2013;78:438-44 pubmed publisher
    ..The resulting 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeleton are functionalized with various electrophiles such as alkyl halide, acid halides, and sulfornyl chloride in high yields. ..
  27. Pachuta Stec A, Dobosz M. Synthesis of new derivatives of bis-3(4-R-delta2-1,2,4-triazolin-5-one). Acta Pol Pharm. 2001;58:307-11 pubmed
    ..Cyclization of these derivatives with an aqueous 2% sodium hydroxide led to formation of new derivatives of delta2-1,2,4-triazolin-5-one [XIII-XXIV]. ..
  28. Borelli K, Ferreira Netto C, Brandão M. Distribution of Fos immunoreactivity in the rat brain after freezing or escape elicited by inhibition of glutamic acid decarboxylase or antagonism of GABA-A receptors in the inferior colliculus. Behav Brain Res. 2006;170:84-93 pubmed
    ..The extent of the brain activation during freezing appears to be limited to the anatomical connections of the dmPAG, whereas an overall activation of the limbic system predominates during escape behavior induced by IC stimulation. ..
  29. Marttila Ichihara F, Castermans K, Auvinen K, oude Egbrink M, Jalkanen S, Griffioen A, et al. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice. J Immunol. 2010;184:3164-73 pubmed publisher
    ..We conclude that tumors use the catalytic activity of VAP-1 to recruit myeloid cells into tumors and to support tumor progression. Small-molecule VAP-1 inhibitors therefore might be a potential new tool for immunotherapy of tumors. ..
  30. El Sharief M, Abbas S, El Bayouki K, El Gammal E. Synthesis of thiosemicarbazones derived from N-(4-hippuric acid)thiosemicarbazide and different carbonyl compounds as antimicrobial agents. Eur J Med Chem. 2013;67:263-8 pubmed publisher
    ..These compounds comprise a new class of promising broad-spectrum antibacterial and antifungal agents. ..
  31. Chandra S, Gupta L, Sangeetika -. Spectroscopic, cyclic voltammetric and biological studies of transition metal complexes with mixed nitrogen-sulphur (NS) donor macrocyclic ligand derived from thiosemicarbazide. Spectrochim Acta A Mol Biomol Spectrosc. 2005;62:453-60 pubmed
    ..Most of the complexes have higher activity than that of the metal free ligand. ..
  32. Carion O, Souplet V, Olivier C, Maillet C, Medard N, El Mahdi O, et al. Chemical micropatterning of polycarbonate for site-specific peptide immobilization and biomolecular interactions. Chembiochem. 2007;8:315-22 pubmed
    ..The method described here is an easy way to modify polycarbonate surfaces for biomolecular interaction studies and should stimulate the use of PC for developing plastic biosensors. ..
  33. Balouch A, Memon N, Bhanger M, Khuhawar M. Utilization of picolinaldehyde-4-phenyl-3-thiosemicarbazone in sodium dodecylsulfate micelles for the spectrophotometric determination of iron, vanadium, and cobalt following partial least-squares regression analysis. J AOAC Int. 2009;92:248-56 pubmed
  34. Chen Y, Skiles G, Shou M, Hickman D, Hsieh F. A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A. Drug Metab Dispos. 2011;39:1668-73 pubmed publisher
    ..A chemical inhibition study in NADPH-fortified S9 fraction indicated that the oxidation of AMG657417 was catalyzed almost exclusively by CYP3A. ..
  35. Kucukguzel S, Oruç E, Rollas S, Sahin F, Ozbek A. Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds. Eur J Med Chem. 2002;37:197-206 pubmed
    ..25 microg mL(-1). None of the compounds showed significant antimicrobial activity against the microorganisms used whereas 3a and 7a inhibited the growth of several bacteria and fungi. ..
  36. Cooper K, McCracken R, Kennedy D. Nitrofurazone accumulates in avian eyes--a replacement for semicarbazide as a marker of abuse. Analyst. 2005;130:824-7 pubmed
  37. Chen H, Zhang T, Zhang J. Synthesis, characterization and properties of nitrogen-rich salts of trinitrophloroglucinol. J Hazard Mater. 2009;161:1473-7 pubmed publisher
    ..It can be concluded that the five compounds are worthy of further in-depth studies as the gas-generating composition, emission reagents and propellants. ..
  38. Kosaka K, Asami M, Konno Y, Oya M, Kunikane S. Identification of antiyellowing agents as precursors of N-nitrosodimethylamine production on ozonation from sewage treatment plant influent. Environ Sci Technol. 2009;43:5236-41 pubmed
    ..HDMS and TMDS were frequently present in surface waters and STP effluents in the Yodo River basin and were also detected in surface waters from several other areas in Japan. ..
  39. Vlastos D, Moshou H, Epeoglou K. Evaluation of genotoxic effects of semicarbazide on cultured human lymphocytes and rat bone marrow. Food Chem Toxicol. 2010;48:209-14 pubmed publisher
    ..On the other hand, oral administration of 50, 100 and 150 mg kg(-1) b.w. of SEM showed a statistically significant effect in MN frequencies on Wistar rats' bone marrow PCEs, with no dose-response pattern. ..
  40. Zhang J. Preparation, characterization and application of thiosemicarbazide grafted multiwalled carbon nanotubes for solid-phase extraction of Cd(II), Cu(II) and Pb(II) in environmental samples. J Environ Sci (China). 2013;25:2331-7 pubmed
    ..5% (n = 6). The new adsorbent shows superior reusability and stability. The procedure was successfully applied to the determination of trace quantities of Cd(II), Cu(II) and Pb(II) in water samples. ..
  41. Ojala C, Ostman J, Ojala W. The saccharide-hydrazide linkage: molecular and crystal structures of the semicarbazide derivatives of D-glucose, D-galactose, and D-xylose, including a 'forbidden' conformation of the galactose derivative. Carbohydr Res. 2002;337:21-9 pubmed
    ..In these semicarbazides the N [bond] N [bond] C[double bond] O torsional angle is approximately 180 degrees, in contrast to the angles ..
  42. Sorouraddin M, Iranifam M, Imani Nabiyyi A. Study of the enhancement of a new chemiluminescence reaction and its application to determination of beta-lactam antibiotics. Luminescence. 2009;24:102-7 pubmed publisher
    ..The proposed method was successfully applied to the determination of ampicillin sodium and amoxicillin in some pharmaceutical dosage forms. ..
  43. Pansare S, Paul E. Organocatalytic asymmetric direct vinylogous aldol reactions of ?-crotonolactone with aromatic aldehydes. Chem Commun (Camb). 2011;47:1027-9 pubmed publisher
    ..The reaction is a simple alternative to the classical vinylogous aldol reaction of silyloxy furans. ..
  44. Dawson D, Wilke T. Joint toxic action of binary mixtures of osteolathyrogens at malformation-inducing concentrations for Xenopus embryos. J Appl Toxicol. 1991;11:415-21 pubmed
    ..The mixture testing approach has potential value in determining compounds that act similarly. ..
  45. Mostafa M. Spectroscopic studies of some thiosemicarbazide compounds derived from Girard's T and P. Spectrochim Acta A Mol Biomol Spectrosc. 2007;66:480-6 pubmed
    ..Finally, the absence of any type of hydrogen bonding (inter- and/or intra-) within these compounds is discussed on the basis of the data of melting points, IR and 1H NMR spectra and molecular weight measurements. ..
  46. Thanigaimalai P, Rao E, Lee K, Sharma V, Roh E, Kim Y, et al. Structure-activity relationship of naphthaldehydethiosemicarbazones in melanogenesis inhibition. Bioorg Med Chem Lett. 2012;22:886-9 pubmed publisher
    ..Conversely, concomitant substitutions decrease the inhibitory potency. In addition, the presence of sulfur in thiosemicarbazone is essential for the activity. ..
  47. Donovalova J, Cigáň M, Stankovicova H, Gašpar J, Danko M, Gaplovsky A, et al. Spectral properties of substituted coumarins in solution and polymer matrices. Molecules. 2012;17:3259-76 pubmed publisher
    ..This is caused by stiffening of the coumarin structure in polar polymer matrices, such as PMMA and PVC, due to higher micro-viscosity than in solution and intermolecular dipole-dipole interaction between chromophore (dopant) and matrix. ..
  48. Proulx C, Sabatino D, Hopewell R, Spiegel J, García Ramos Y, Lubell W. Azapeptides and their therapeutic potential. Future Med Chem. 2011;3:1139-64 pubmed publisher
    ..This review aims to provide a historical look at the development of azapeptide science along with a focus on recent developments and perspectives on the future of this useful tool for medicinal chemistry. ..
  49. Maranghi F, Tassinari R, Lagatta V, Moracci G, Macri C, Eusepi A, et al. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol. 2009;47:472-9 pubmed publisher
    ..SEM administration during juvenile period exerted pleiotropic effects and further studies are suggested to elucidate mechanisms. ..
  50. el Sabbagh O, Rady H. Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation. Eur J Med Chem. 2009;44:3680-6 pubmed publisher
    ..The antiviral activity of the new compounds against Hepatitis A Virus (HAV) using the plague infectivity reduction assay revealed that the acridine 4 and the hydrazone 12 were more active than the reference drug amantadine. ..
  51. Jain J, Kumar Y, Sinha R, Kumar R, Stables J. Menthone aryl acid hydrazones: a new class of anticonvulsants. Med Chem. 2011;7:56-61 pubmed
    ..menthone Schiff bases, menthone semicarbazides and thiosemicarbazides.
  52. An H, Henry M, Cain T, Tran B, Paek H, Farley D. Determination of total nitrofuran metabolites in shrimp muscle using liquid chromatography/tandem mass spectrometry in the atmospheric pressure chemical ionization mode. J AOAC Int. 2012;95:1222-33 pubmed
    ..Interday precision with samples containing incurred AOZ concentrations of 0.92 to 17.8 ppb performed over a year was 10.4% RSD. The method is accurate and precise for determining nitrofuran concentrations in the edible tissue of shrimp. ..
  53. Kitaoka T, Yoshiyama C, Uemura F. Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses. Carbohydr Polym. 2013;92:374-9 pubmed publisher
    ..This approach to designing carbohydrate-based scaffolds should provide a basis for the functional development of glyco-decorated biointerfaces for cell culture applications. ..
  54. Xie Y, Li P, Zhang J, Wang H, Qian H, Yao W. Comparative studies by IR, Raman, and surface-enhanced Raman spectroscopy of azodicarbonamide, biurea and semicarbazide hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2013;114:80-4 pubmed publisher
  55. Dziadulewicz E, Walpole C, Snell C, Wrigglesworth R, Hughes G, Beattie D, et al. Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold. Bioorg Med Chem Lett. 2001;11:705-9 pubmed
    ..A beta-turn overlay hypothesis has been used to transform the core scaffold of a selective non-peptide bradykinin B2 receptor antagonist into ligands specifically recognized by the CCK2 or NK1 receptors. ..
  56. Borelli K, Ferreira Netto C, Coimbra N, Brandão M. Fos-like immunoreactivity in the brain associated with freezing or escape induced by inhibition of either glutamic acid decarboxylase or GABAA receptors in the dorsal periaqueductal gray. Brain Res. 2005;1051:100-11 pubmed
    ..Therefore, the freezing elicited by activation of dlPAG appears to be related to the acquisition of aversive information, whereas most brain structures involved in the defense reaction are recruited during escape. ..
  57. Mercier N, El Hadri K, Osborne Pellegrin M, Nehme J, Perret C, Labat C, et al. Modifications of arterial phenotype in response to amine oxidase inhibition by semicarbazide. Hypertension. 2007;50:234-41 pubmed
    ..Because these abnormalities are essentially absent in SSAO-deficient mice, our results suggest that lysyl oxidase inhibition is responsible for the major part of the vascular phenotype of SCZ-treated rats. ..
  58. Nguyen H, Maia P, Deflon V, Abram U. Oxotechnetium(V) complexes with a novel class of tridentate thiosemicarbazide ligands. Inorg Chem. 2009;48:25-7 pubmed publisher
    ..The compounds represent the first examples of oxotechnetium(V) complexes with NS chelate-bonded thiosemicarbazones. ..
  59. Yi W, Cao R, Wen H, Yan Q, Zhou B, Ma L, et al. Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009;19:6157-60 pubmed publisher
    ..The inhibition kinetics and inhibition mechanism study revealed that compound 9a was reversible and competitive type inhibitor, whereas compound 13a was reversible and competitive-uncompetitive mixed-II type inhibitor. ..
  60. Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A. Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats. Toxicol Pathol. 2010;38:598-605 pubmed publisher
    ..These results suggest that growing animals are more susceptible to toxicity of SEM-HCl than adults are. Effects and the induced lesions link to the developing stage of the target organs. ..
  61. Anita K, Rajmuhon Singh N. Absorption spectral analysis of 4f-4f transitions for the complexation of Pr(III) and Nd(III) with thiosemicarbazide in absence and presence of Zn(II) in aqueous and organic solvents. Spectrochim Acta A Mol Biomol Spectrosc. 2011;81:117-21 pubmed publisher
    ..Various solvents and their equimolar mixtures are also used to discuss the participation of solvents in the complexation...
  62. Li M, Zhang L, Zhang D, Ji B, Zhao J. Synthesis, crystal structures, and biological evaluation of manganese(II) and nickel(II) complexes of 4-cyclohexyl-1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide. Eur J Med Chem. 2011;46:4383-90 pubmed publisher
    ..The tested compounds may exert their cytotoxicity activity via induced loss of MMP. ..
  63. Wang Y, Chan W. Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography-Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples. J Agric Food Chem. 2016;64:2802-8 pubmed publisher
  64. Hashmi M, Anders M. Enzymatic reaction of beta-N-methylaminoalanine with L-amino acid oxidase. Biochim Biophys Acta. 1991;1074:36-9 pubmed
    ..These results indicate that BMAA is converted by L-AAO to the corresponding alpha-imino acid, which undergoes hydrolysis to beta-N-methylaminopyruvate. The alpha-keto acid is readily oxidized to N-methylglycine by hydrogen peroxide. ..
  65. Nobre M, Sandner G, Brandão M. Enhancement of acoustic evoked potentials and impairment of startle reflex induced by reduction of GABAergic control of the neural substrates of aversion in the inferior colliculus. Hear Res. 2003;184:82-90 pubmed
  66. Saito Y, Nishio K, Yoshida Y, Niki E. Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species. Toxicology. 2005;210:235-45 pubmed
  67. Maczyński M, Zimecki M, Ryng S. Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative. Acta Pol Pharm. 2004;61 Suppl:82-3 pubmed
    ..In the present study, we examined the effect of compound RM2 on the spontaneous proliferative response of splenocytes and mitogen-induced splenocyte proliferation. Synthesis and biological effect is reported. ..
  68. Drasković B, Bogdanović G, Leovac V, Brceski I, Poleti D. Transition metal complexes with thiosemicarbazide-based ligands. LIII. [4-(2-Diphenylphosphino-alpha-ethoxybenzyl-kappaP)-S-methyl-1-(4-oxidopent-3-en-4-ylidene-kappaO)thiosemicarbazido-kappa(2)N(1),N(4)]nickel(II). Acta Crystallogr C. 2006;62:m319-22 pubmed
    ..pi interaction with the opposing phenyl ring. There are no hydrogen bonds; instead, numerous intermolecular C-H...pi interactions dominate in the crystal packing. ..
  69. Bhat A, Athar F, van Zyl R, Chen C, Azam A. Synthesis and biological evaluation of novel 4-substituted 1-{[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]methylidene}thiosemicarbazides as new class of potential antiprotozoal agents. Chem Biodivers. 2008;5:764-76 pubmed publisher
    ..Only one compound out of six showed an activity comparable to standard drug. ..
  70. Cushing T, Baichwal V, Berry K, Billedeau R, Bordunov V, BROKA C, et al. A novel series of IKK? inhibitors part II: description of a potent and pharmacologically active series of analogs. Bioorg Med Chem Lett. 2011;21:423-6 pubmed publisher
    ..In this Letter we document our efforts at further optimization of this series, culminating in 2 with submicromolar potency in a HWB assay and efficacy in a CIA mouse model. ..
  71. Plech T, Wujec M, Siwek A, Kosikowska U, Malm A. Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety. Eur J Med Chem. 2011;46:241-8 pubmed publisher
    ..An attempt was made to clarify the influence of the nature/position of substituents on antibacterial activity of compounds described...
  72. Van Poucke C, Detavernier C, Wille M, Kwakman J, Sorgeloos P, Van Peteghem C. Investigation into the possible natural occurence of semicarbazide in Macrobrachium rosenbergii prawns. J Agric Food Chem. 2011;59:2107-12 pubmed publisher
    ..In addition to this animal trial, commercial samples of other crustacean species, the shell and meat of which were analyzed separately, were also analyzed for the presence of SEM. ..
  73. Xu S, Hao Y, Sun W, Fang C, Lu X, Li M, et al. 2:1 multiplexing function in a simple molecular system. Sensors (Basel). 2012;12:4421-30 pubmed publisher
    ..When solvents are introduced as the third control, a molecular 2:1 multiplexer is constructed to report selectively the inputs. Therefore, a molecular 2:1 multiplexer is realized in a simple molecular system. ..
  74. He J, Wang X, Zhao X, Liang Y, He H, Fu L. Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety. Eur J Med Chem. 2012;54:925-30 pubmed publisher
    ..From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their antitumor activity. ..
  75. Novaković S, Bogdanović G, Leovac V, Rodić M, Vojinović Jesić L, Ivkovic S. (E)-4-[(2-carbamoylhydrazinylidene)methyl]-3-hydroxy-5-hydroxymethyl-2-methylpyridin-1-ium nitrate. Acta Crystallogr C. 2013;69:761-4 pubmed publisher
    ..01?Å). The molecules are linked into flat layers by N-H···O and C-H···O hydrogen bonds. O-H···O hydrogen bonds involving the hydroxymethyl group as a donor interconnect the layers into a three-dimensional structure. ..
  76. Crosbie A, Callingham B. Semicarbazide-sensitive amine oxidases in sheep plasma: interactions with some substrates and inhibitors. J Neural Transm Suppl. 1994;41:427-32 pubmed
  77. Brandão M, Borelli K, Nobre M, Santos J, Albrechet Souza L, Oliveira A, et al. Gabaergic regulation of the neural organization of fear in the midbrain tectum. Neurosci Biobehav Rev. 2005;29:1299-311 pubmed
    ..It is suggested that GABAergic mechanisms of MT are also called into play when sensory gating of the MT is activated during different emotional states. ..
  78. Novaković S, Bogdanović G, Fraisse B, Ghermani N, Bouhmaida N, Spasojević de Biré A. Topological features of both electron density and electrostatic potential in the bis(thiosemicarbazide)zinc(II) dinitrate complex. J Phys Chem A. 2007;111:13492-505 pubmed
    ..Finally, among other electrostatic potential critical points, the values at the maxima corresponding to the nuclear sites were used as indices of the hydrogen-bonding capacity of the thiosemicarbazide ligand. ..
  79. Che X. Bis[1-(2-hydroxyethyl)-4,10-diazapyrazolo[4,3-b]fluoren-5(1H)-one thiosemicarbazonato]zinc(II) dimethylformamide trisolvate monohydrate. Acta Crystallogr C. 2008;64:m5-7 pubmed publisher
    ..There are three dimethylformamide molecules and one water molecule solvating the complex. The coordination behavior of the ligand is compared with that of related ligands in similar complexes. ..
  80. Parmar S, Kumar Y. Synthesis, spectroscopic, and antimicrobial studies of the bivalent nickel, and copper complexes of thiosemicarbazide. Chem Pharm Bull (Tokyo). 2009;57:603-6 pubmed
    ..Thiosemicarbazide and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. ..
  81. Gao R, Hu Z, Chang X, He Q, Zhang L, Tu Z, et al. Chemically modified activated carbon with 1-acylthiosemicarbazide for selective solid-phase extraction and preconcentration of trace Cu(II), Hg(II) and Pb(II) from water samples. J Hazard Mater. 2009;172:324-9 pubmed publisher
    ..The relative standard deviation under optimum conditions is less than 4.0% (n=8). The prepared sorbent was applied for the preconcentration of trace Cu(II), Hg(II) and Pb(II) in certified and water samples with satisfactory results. ..
  82. Yang Y, Ko S, Shin I, Tae J. Fluorescent detection of methylmercury by desulfurization reaction of rhodamine hydrazide derivatives. Org Biomol Chem. 2009;7:4590-3 pubmed publisher
    ..In this report, we describe an irreversible rhodamine chemosensor for the detection of methylmercury and real-time monitoring of methylmercury in living cells and organisms. ..
  83. Mercier N, Moldes M, El Hadri K, Feve B. Regulation of semicarbazide-sensitive amine oxidase expression by tumor necrosis factor-alpha in adipocytes: functional consequences on glucose transport. J Pharmacol Exp Ther. 2003;304:1197-208 pubmed
    ..This suggests a potential role of this regulatory process in the pathogenesis of glucose homeostasis dysregulations observed during diseases accompanied by TNF-alpha overproduction, such as cachexia or obesity. ..
  84. El Ayaan U, Kenawy I, El Reash Y. Synthesis, thermal and spectral studies of first-row transition metal complexes with Girard P reagent-based ligand. Spectrochim Acta A Mol Biomol Spectrosc. 2007;68:211-9 pubmed
    ..Thermal stability and degradation kinetics have been measured using thermogravimetric analyzer. Kinetic parameters were obtained for each stage of thermal degradation of complexes using Coats-Redfern method. ..
  85. Barsoum F, Girgis A. Facile synthesis of bis(4,5-dihydro-1H-pyrazole-1-carboxamides) and their thio-analogues of potential PGE(2) inhibitory properties. Eur J Med Chem. 2009;44:2172-7 pubmed publisher
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    b>Semicarbazides, besides possessing medicinal properties, also find wide applications in agriculture and industry...
  87. El Metwally N, Al Hazmi G. Spectroscopic evaluation for VO(II), Ni(II), Pd(II) and Cu(II) complexes derived from thiosemicarbazide: a special emphasis on EPR study and DNA cleavage. Spectrochim Acta A Mol Biomol Spectrosc. 2013;107:289-95 pubmed publisher
    ..The effect of all compounds on DNA were photographed. A successive degradation for the DNA target was observed with Pd(II) and Ni(II) complexes beside their original ligand. ..
  88. Maruyama W, Naoi M, Kasamatsu T, Hashizume Y, Takahashi T, Kohda K, et al. An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells. J Neurochem. 1997;69:322-9 pubmed
    ..Apoptosis induced by neurotoxins may be a mechanism underlying the cell death of dopamine neurons in the substantia nigra of Parkinson's disease. ..
  89. Vianna D, Graeff F, Landeira Fernandez J, Brandao M. Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray. Learn Mem. 2001;8:164-9 pubmed
    ..A discussion on different neural circuitries that might underlie different inhibitory and active defensive behavioral patterns that animals display during threatening situations is presented. ..
  90. Wujec M, Stefanska J, Siwek A, Tatarczak M. Synthesis, lipophilicity and antimicrobial activity of new derivatives of thiosemicarbazides and 1,2,4-triazoline-5-thione. Acta Pol Pharm. 2009;66:73-82 pubmed
    ..All compounds were screened for their in vitro activity against some species of aerobic bacteria and fungi. The lipophilicity of the synthesized molecules was also studied. ..
  91. Stastny K, Frgalova K, Hera A, Vass M, Franek M. In-house validation of liquid chromatography tandem mass spectrometry for determination of semicarbazide in eggs and stability of analyte in matrix. J Chromatogr A. 2009;1216:8187-91 pubmed publisher
    ..The study proved by a two-sampling test that SEM at levels of 17. 7, 1.2, 10.6 and 0.47 microg kg(-1) was stable for up to 12 months. ..
  92. El Ashry E, Aly A, Aouad M, Amer M. Revisit to the reaction of o-phenylene diamine with thiosemicarbazide to give benzimidazole-2-thione rather than benzotriazine-2-thione and its glycosylation. Nucleosides Nucleotides Nucleic Acids. 2010;29:698-706 pubmed publisher
    ..The regioselectivity of glycosylation reaction has been investigated. ..