trimethylsilyl compounds


Summary: Organic silicon derivatives used to characterize hydroxysteroids, nucleosides, and related compounds. Trimethylsilyl esters of amino acids are used in peptide synthesis.

Top Publications

  1. Lou W, Zong M. Efficient kinetic resolution of (R,S)-1-trimethylsilylethanol via lipase-mediated enantioselective acylation in ionic liquids. Chirality. 2006;18:814-21 pubmed
    ..The preparative scale kinetic resolution of (R,S)-1-TMSE in C4MIm.PF6 is shown to be very promising and useful for the industrial production of enantiopure (S)-1-TMSE. ..
  2. Lou W, Chen L, Zhang B, Smith T, Zong M. Using a water-immiscible ionic liquid to improve asymmetric reduction of 4-(trimethylsilyl)-3-butyn-2-one catalyzed by immobilized Candida parapsilosis CCTCC M203011 cells. BMC Biotechnol. 2009;9:90 pubmed publisher
  3. Shibata J, Murakami K, Wierzba K, Aoyagi Y, Hashimoto A, Sano M, et al. Anticancer effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) against A549 non-small cell lung cancer cell line is related to its anti-invasive activity. Anticancer Res. 2000;20:3169-76 pubmed
    ..Taking into account the pharmacological properties of TAC-101, it is expected that TAC-101 may be a suitable candidate drug for the treatment of lung cancer patients, especially those with a predictable metastasizing potential. ..
  4. Liu X, Wang P, Yang Y, Wang P, Yang Q. (R)-(+)-Binol-functionalized mesoporous organosilica as a highly efficient pre-chiral catalyst for asymmetric catalysis. Chem Asian J. 2010;5:1232-9 pubmed publisher
    ..This work demonstrates the positive effect of the rigid pore wall in increasing the enantioselectivity of the chiral PMOs. ..
  5. Verhoeckx K, Gaspari M, Bijlsma S, van der Greef J, Witkamp R, Doornbos R, et al. In search of secreted protein biomarkers for the anti-inflammatory effect of beta2-adrenergic receptor agonists: application of DIGE technology in combination with multivariate and univariate data analysis tools. J Proteome Res. 2005;4:2015-23 pubmed
    ..The inhibition of MIP-1beta by zilpaterol and the involvement of the beta(2)-AR and cAMP were confirmed using a specific immunoassay. ..
  6. Hernandez E, Burgos C, Alicea E, Soderquist J. B-allenyl- and B-(gamma-trimethylsilylpropargyl)-10-phenyl-9-borabicyclo[3.3.2]decanes: asymmetric synthesis of propargyl and alpha-allenyl 3-degree-carbinols from ketones. Org Lett. 2006;8:4089-91 pubmed
    ..The air-stable boron byproduct is efficiently recovered and recycled back to either 1 or 2. The ozonolysis and bromination of 9 provide nonracemic alpha-hydroxy acids and gamma-bromopropynyl carbinols, respectively. ..
  7. Edrington T, Farrow R, Loneragan G, Ives S, Engler M, Wagner J, et al. Influence of beta-agonists (ractopamine HCl and zilpaterol HCl) on fecal shedding of Escherichia coli O157:H7 in feedlot cattle. J Food Prot. 2009;72:2587-91 pubmed
    ..1%). The current research showed minimal effects of beta-agonists on fecal shedding of E. coli O157:H7 and indicated that these compounds (fed immediately prior to slaughter) are not a cause for concern from a food safety standpoint...
  8. Retail B, Rose R, Pearce J, Greaves S, Orr Ewing A. The dynamics of reaction of Cl atoms with tetramethylsilane. Phys Chem Chem Phys. 2008;10:1675-80 pubmed publisher
    ..The large Arrhenius pre-exponential factor previously reported for this reaction is reconciled with the tight differential scattering observed in our study by considering the large size of the TMS molecule. ..
  9. Maity S, Basu N, Ghosh R. Efficient activation of thioglycosides with N-(p-methylphenylthio)-?-caprolactam-TMSOTf. Carbohydr Res. 2012;354:40-8 pubmed publisher
    ..Both 'armed' and 'disarmed' thioglycosyl donors were activated for glycosidic bond formation. Notably, this reagent combination works well in reactivity-based one-pot oligosaccharide assembly strategy. ..

More Information

Publications117 found, 100 shown here

  1. Guchhait S, Chaudhary V, Madaan C. A chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: generation of heteroaromatic molecular diversity. Org Biomol Chem. 2012;10:9271-7 pubmed publisher
    ..This reaction coupling with cascade cyclization provides various privileged tetracyclic heteroaromatic scaffolds. ..
  2. Shen P, Wong S, Yong E. Sensitive and rapid method to quantify icaritin and desmethylicaritin in human serum using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;857:47-52 pubmed
    ..51+/-1.6 nM) in sera of human volunteers after ingestion of an aqueous decoction of Epimedium. This sensitive method can be used to quantify serum levels of icaritin and desmethylicaritin for pharmacokinetic studies. ..
  3. Li J, Sha Y. A convenient synthesis of amino acid methyl esters. Molecules. 2008;13:1111-9 pubmed
    ..This method is not only compatible with natural amino acids, but also with other aromatic and aliphatic amino acids. ..
  4. Luqué L, Johnson B, Martin J, Miller M, Hodgen J, Hutcheson J, et al. Zilpaterol hydrochloride supplementation has no effect on the shelf life of ground beef. J Anim Sci. 2011;89:817-25 pubmed publisher
    ..Overall, ground beef from cattle supplemented with ZH was equal to or better than CON for sensory color and discoloration, instrumental color, and stability variables, including TBA reactive substances and aerobic plate counts. ..
  5. Hansen S, Frylinck L, Strydom P. The effect of vitamin D(3) supplementation on texture and oxidative stability of beef loins from steers treated with zilpaterol hydrochloride. Meat Sci. 2012;90:145-51 pubmed publisher
  6. Molnár B, Fodor B, Boldizsár I, Molnár Perl I. Trimethylsilyl speciations of cathine, cathinone and norephedrine followed by gas chromatography mass spectrometry: Direct sample preparation and analysis of khatamines. J Chromatogr A. 2016;1440:172-178 pubmed publisher
    ..061w/w% CAT and 0.014w/w% NE contents were obtained. In this tissue CTN was not found. Very likely attributable to the unfavorable climate for the plant: grown in Hungary of temperate zone and naturalized in the tropical Africa. ..
  7. Beckett J, Delmore R, Duff G, Yates D, Allen D, Lawrence T, et al. Effects of zilpaterol hydrochloride on growth rates, feed conversion, and carcass traits in calf-fed Holstein steers. J Anim Sci. 2009;87:4092-100 pubmed publisher
    ..1. This effect was not observed in Exp. 2. Holstein steers clearly respond to the beta-agonist ZH, and 20 d of feeding ZH with a 3-d withdrawal significantly increased carcass weights, muscling, and carcass leanness. ..
  8. Becker L, Bergfeld W, Belsito D, Hill R, Klaassen C, LIEBLER D, et al. Safety assessment of silylates and surface-modified siloxysilicates. Int J Toxicol. 2013;32:5S-24S pubmed publisher
  9. Marsol Vall A, Balcells M, Eras J, Canela Garayoa R. Injection-port derivatization coupled to GC-MS/MS for the analysis of glycosylated and non-glycosylated polyphenols in fruit samples. Food Chem. 2016;204:210-7 pubmed publisher
    ..Finally, the method was applied to real fruit samples containing the target compounds. The complete chromatographic runtime was 15min, which is faster than reported for recent HPLC methods able to analyze similar compounds...
  10. Reich H, Sikorski W, Sanders A, Jones A, Plessel K. Multinuclear NMR study of the solution structure and reactivity of tris(trimethylsilyl)methyllithium and its iodine ate complex. J Org Chem. 2009;74:719-29 pubmed publisher
    ..Additional calibrations are presented for the sensitive yet chemically inert (13)C NMR chemical shift thermometer 1-H. ..
  11. Chu L, Qing F. Copper-catalyzed oxidative trifluoromethylation of terminal alkenes using nucleophilic CF3SiMe3: efficient C(sp3)-CF3 bond formation. Org Lett. 2012;14:2106-9 pubmed publisher
    ..This method allows access to a variety of trifluoromethylated allylic compounds. ..
  12. Zhang X, Song X, Li H, Zhang S, Chen X, Yu X, et al. An organocatalytic cascade approach toward polysubstituted quinolines and chiral 1,4-dihydroquinolines-unanticipated effect of N-protecting groups. Angew Chem Int Ed Engl. 2012;51:7282-6 pubmed publisher
    ..In contrast, chiral 1,4-dihydroquinolines are obtained with an electron-withdrawing sulfonyl group (left)...
  13. Sacchetti A, Silvani A, Gatti F, Lesma G, Pilati T, Trucchi B. Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin. Org Biomol Chem. 2011;9:5515-22 pubmed publisher
    ..Further elaboration of the cyanide group allowed the preparation of a new oxindole-based peptidomimetic and a pharmaceutically relevant spirohydantoin. ..
  14. Looper R, Haussener T, Mack J. Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines. J Org Chem. 2011;76:6967-71 pubmed publisher
    ..Typically the reaction is complete in 15 min for primary and secondary aliphatic amines at rt. Hindered amines and anilines are also competent nucleophiles but require extended reaction times. ..
  15. Zhang W, Stambouli M, Pareau D. Detoxifying emulsion for overdosed aspirin intoxication. Int J Pharm. 2013;441:598-602 pubmed publisher
    ..1 mol/L sodium hydroxide as the inner aqueous phase in a volume ratio of 2 between internal aqueous phase and the oil phase. ..
  16. Boxer M, Yamamoto H. Tris(trimethylsilyl)silyl-governed aldehyde cross-aldol cascade reaction. J Am Chem Soc. 2006;128:48-9 pubmed
    ..HNTf2 is proposed to be an initiator, and highly Lewis acidic TTMSSNTf2 is the true catalyst. ..
  17. Rontani J, Aubert C. Hydrogen and trimethylsilyl transfers during EI mass spectral fragmentation of hydroxycarboxylic and oxocarboxylic acid trimethylsilyl derivatives. J Am Soc Mass Spectrom. 2008;19:66-75 pubmed
    ..Several fragmentation pathways involving trimethylsilyl and hydrogen transfers were proposed to explain the formation of these different fragment ions and were substantiated by deuterium labeling. ..
  18. Garmyn A, Shook J, VanOverbeke D, Beckett J, Delmore R, Yates D, et al. The effects of zilpaterol hydrochloride on carcass cutability and tenderness of calf-fed Holstein steers. J Anim Sci. 2010;88:2476-85 pubmed publisher
  19. Isidorov V, Rusak M, Szczepaniak L, Witkowski S. Gas chromatographic retention indices of trimethylsilyl derivatives of mono- and diglycerides on capillary columns with non-polar stationary phases. J Chromatogr A. 2007;1166:207-11 pubmed
    ..The article also presents mass spectra for a series of those glycerides which were not characterized earlier by these parameters. ..
  20. Kawai H, Tachi K, Tokunaga E, Shiro M, Shibata N. Cinchona alkaloid-catalyzed asymmetric trifluoromethylation of alkynyl ketones with trimethylsilyl trifluoromethane. Org Lett. 2010;12:5104-7 pubmed publisher
    ..Biologically attractive aryl heteroaryl trifluoromethyl carbinols were also synthesized...
  21. Hu K, Ellinger J, Chylla R, Markley J. Measurement of absolute concentrations of individual compounds in metabolite mixtures by gradient-selective time-zero 1H-13C HSQC with two concentration references and fast maximum likelihood reconstruction analysis. Anal Chem. 2011;83:9352-60 pubmed publisher
    ..The new approach is suitable for automatic metabolite profiling by simultaneous quantification of multiple metabolites in a complex mixture. ..
  22. Zhang B, Cheng J, Lou W, Wang P, Zong M. Efficient anti-Prelog enantioselective reduction of acetyltrimethylsilane to (R)-1-trimethylsilylethanol by immobilized Candida parapsilosis CCTCC M203011 cells in ionic liquid-based biphasic systems. Microb Cell Fact. 2012;11:108 pubmed publisher
    ..The substantially improved biocatalytic process appears to be effective and competitive on a preparative scale. ..
  23. Sebok A, Vasanits Zsigrai A, Helenkár A, Zaray G, Molnár Perl I. Multiresidue analysis of pollutants as their trimethylsilyl derivatives, by gas chromatography-mass spectrometry. J Chromatogr A. 2009;1216:2288-301 pubmed publisher
    ..The practical utility of the method was shown by the identification and quantification of the pollutant contents of Hungarian influent and effluent wastewaters (for six consecutive months and that of the Danube River for 2 months). ..
  24. Han S, Gao X, Krische M. Iridium-catalyzed anti-diastereo- and enantioselective carbonyl (trimethylsilyl)allylation from the alcohol or aldehyde oxidation level. J Am Chem Soc. 2010;132:9153-6 pubmed publisher
  25. Chau H, Kawase T, Oida T. Preparation of dicarboxylic acid-type gemini surfactant via Diels-Alder reaction & ozone oxidation. J Oleo Sci. 2013;62:409-14 pubmed
  26. Stuparu M, Gramlich V, Stanger A, Schlüter A. Double-stranded cycles: toward C84's belt region. J Org Chem. 2007;72:424-30 pubmed
    ..With the help of detailed NMR correlation studies and DFT computations, all important aspects were clarified including an unexpected selective H/D exchange at the naphthalenic moieties. ..
  27. Smith J, Jones R, Booker G, Pyke S. Sequential and selective Buchwald-Hartwig amination reactions for the controlled functionalization of 6-bromo-2-chloroquinoline: synthesis of ligands for the Tec Src homology 3 domain. J Org Chem. 2008;73:8880-92 pubmed publisher
    ..Introduction of the amino functionality of the 6-heterocyclic 2-aminoquinolines involved additional Buchwald-Hartwig chemistry utilizing lithium bis(trimethylsilyl)amide as an ammonia equivalent. ..
  28. Kern C, Meyer T, Droux S, Schollmeyer D, Miculka C. Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol. J Med Chem. 2009;52:1773-7 pubmed publisher
    ..X-ray crystallography revealed the absolute configuration of (-)-1 to be 6R,7R. ..
  29. Inoue Y, Nakayama Y, Sako T, Minagawa N, Abe Y, Nagato M, et al. 4- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line. In Vivo. 2007;21:381-7 pubmed
    ..Because the compounds inducing apoptotic activity are frequent targets of cancer therapy, TAC-101 may be a good candidate for use in the treatment of colon cancer. ..
  30. Qin Z, Zhang J, Troyan I, Palasyuk T, Eremets M, Chen X. High-pressure study of tetramethylsilane by Raman spectroscopy. J Chem Phys. 2012;136:024503 pubmed publisher
    ..We also observed two other possible phase transitions at 49-69 GPa and 96 GPa. No indication of metallization in tetramethylsilane was found with stepwise compression to 142 GPa. ..
  31. Verhoeckx K, Doornbos R, Witkamp R, van der Greef J, Rodenburg R. Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages. Int Immunopharmacol. 2006;6:1-7 pubmed
    ..We propose that the up-regulation of these proteins could play a role in the adverse effects of prolonged excessive usage of beta2-AR agonists on the airways besides the desensitization of the beta2-AR. ..
  32. Wang F, Qu M, Chen F, Li L, Shi M. An unusual Me3SiI-promoted [4+2] annulation and reduction: an efficient approach to construct 4H-benzopyrans. Chem Commun (Camb). 2012;48:437-9 pubmed publisher
    ..This tandem reaction proceeds with high efficiency through nucleophilic addition, silyl enol ether formation, substitution, reduction, and intramolecular nucleophilic cyclization. ..
  33. Cacho J, Campillo N, Vinas P, Hernández Córdoba M. Stir bar sorptive extraction coupled to gas chromatography-mass spectrometry for the determination of bisphenols in canned beverages and filling liquids of canned vegetables. J Chromatogr A. 2012;1247:146-53 pubmed publisher
    ..Recovery studies at two concentration levels, 0.1 and 1 ?g L?¹, were performed providing recoveries in the 86-122% range. The samples analyzed contained higher concentrations of BPA than of the other analytes. ..
  34. Tang Q, Xu Y, Wu D, Sun Y, Wang J, Xu J, et al. Studies on a new carrier of trimethylsilyl-modified mesoporous material for controlled drug delivery. J Control Release. 2006;114:41-6 pubmed
    ..Furthermore, the release rate of ibuprofen could be well modulated by changing the grafted content of TMS groups, and was found to decrease with increasing grafted amount of TMS groups. ..
  35. Maresova V, Chadt J, Novakova E. Screening and semiquantitative analysis of drugs and drugs of abuse in human serum samples using gas chromatography-mass spectrometry. Neuro Endocrinol Lett. 2008;29:749-54 pubmed
  36. Alcudia León M, Lucena R, Cardenas S, Valcarcel M. Stir membrane liquid-liquid microextraction. J Chromatogr A. 2011;1218:869-74 pubmed publisher
    ..8 ng/L (for 2,4,5-trichlorophenol) to 22.9 ng/L (for 3-chlorophenol) with a relative standard deviation lower than 8.7% (for 2,6-dichlorophenol). ..
  37. Martin R, Rodríguez Rivero M, Buchwald S. Domino cu-catalyzed C--N coupling/hydroamidation: a highly efficient synthesis of nitrogen heterocycles. Angew Chem Int Ed Engl. 2006;45:7079-82 pubmed
  38. Avendaño Reyes L, Torres Rodríguez V, Meraz Murillo F, Pérez Linares C, Figueroa Saavedra F, Robinson P. Effects of two beta-adrenergic agonists on finishing performance, carcass characteristics, and meat quality of feedlot steers. J Anim Sci. 2006;84:3259-65 pubmed
    ..In general, feedlot performance was greatly enhanced by beta-adrenergic agonists, and meat tenderness from treated animals was classified as intermediate. Furthermore, meat color was not altered by beta-agonist supplementation. ..
  39. Wang J, Dong M, Shim W, Kannan N, Li D. Improved cleanup technique for gas chromatographic-mass spectrometric determination of alkylphenols from biota extract. J Chromatogr A. 2007;1171:15-21 pubmed
    ..Simultaneous measurement of these compounds in water, sediment and biota; the resulting bio-concentration factor and their relationships confirm previously published works, validating the method applied. ..
  40. Li Y, Mo H, Lian G, Yu B. Revisit of the phenol O-glycosylation with glycosyl imidates, BF?·OEt? is a better catalyst than TMSOTf. Carbohydr Res. 2012;363:14-22 pubmed publisher
  41. Wu Q, Zhou J, Yao Z, Xu F, Shen Q. Lanthanide amides [(Me(3)Si)(2)N](3)Ln(?-Cl)Li(THF)(3) catalyzed hydrophosphonylation of aryl aldehydes. J Org Chem. 2010;75:7498-501 pubmed publisher
    ..1 mol % [(Me(3)Si)(2)N](3)La(?-Cl)Li(THF)(3) at room temperature within 5 min. The existence of LiCl in the catalyst was a key factor affecting the catalytic activity. The mechanism for the process of high efficiency was proposed. ..
  42. Botana A, Aguilar J, Nilsson M, Morris G. J-modulation effects in DOSY experiments and their suppression: the Oneshot45 experiment. J Magn Reson. 2011;208:270-8 pubmed publisher
    ..The sensitivity loss is negligible and the added phase cycling is modest. The new method is illustrated for a widely-used general purpose DOSY pulse sequence, Oneshot. ..
  43. Wang Q, Dong X, Xiao T, Zhou L. PhI(OAc)2-mediated synthesis of 6-(trifluoromethyl)phenanthridines by oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions. Org Lett. 2013;15:4846-9 pubmed publisher
    ..The reaction allows the direct formation of C-CF3 bonds and rapid access to phenanthridine ring systems in one catalytic cycle. ..
  44. Gironés M, Bolhuis Versteeg L, Lammertink R, Wessling M. Flux stabilization of silicon nitride microsieves by backpulsing and surface modification with PEG moieties. J Colloid Interface Sci. 2006;299:831-40 pubmed
    ..On the other hand, reduced fouling was observed with PEG-modified microsieves in combination with backpulsing and air sparging. ..
  45. Chiou S, Wu Y, Lin G. Activation mechanisms of butyrylcholinesterase by 2,4,6-trinitrotoluene, 3,3-dimethylbutyl-N-n-butylcarbamate, and 2-trimethylsilyl-ethyl-N-n-butylcarbamate. Appl Biochem Biotechnol. 2008;150:337-44 pubmed publisher
    ..Therefore, TNT, and compounds 1 and 2 may act as the excess of butyrylcholine in the substrate activator for the butyrylcholinesterase catalyzed reactions. ..
  46. Zhu S, Yan W, Mao B, Jiang X, Wang R. Enantioselective nucleophilic addition of trimethylsilylacetylene to n-phosphinoylimines promoted by C(2)-symmetric proline-derived beta-amino alcohol. J Org Chem. 2009;74:6980-5 pubmed publisher
    ..Furthermore, the Michael-type addition process of C horizontal lineN alkynylation was studied and proposed on the basis of React (31)P NMR investigation. ..
  47. Leutritz T, Hilfert L, Smalla K, Speck O, Zhong K. Accurate quantification of water-macromolecule exchange induced frequency shift: effects of reference substance. Magn Reson Med. 2013;69:263-8 pubmed publisher
    ..From the experimental data, the equilibrium binding constant between BSA and TMSP has been quantified to be K(d) = 1.3 ± 0.4, and the estimated number of interaction sites for BSA is 12.7 ± 2.6. ..
  48. Strydom P, Hope Jones M, Frylinck L, Webb E. The effects of a beta-agonist treatment, vitamin D3 supplementation and electrical stimulation on meat quality of feedlot steers. Meat Sci. 2011;89:462-8 pubmed publisher
    ..001). 6D7M, 6D7M7N and Z remained significantly tougher than C (P<0.001), while 3D7M and 9D1M improved WBSF under NES conditions. ES is more effective to alleviate beta-agonist induced toughness than high vitamin D3 supplements. ..
  49. Weber M, Dikeman M, Jaeger J, Unruh J, Murray L, Houser T. Effects of feeding a single or sequence of beta-adrenergic agonists on cull cow meat quality. Meat Sci. 2013;93:275-81 pubmed publisher
    ..Color and sensory traits of meat from RH+ZH cows were not different from C but flavor intensity was greater and off-flavor less than for C cows. ..
  50. Li Y, Tran T, Xu Y, Vecchio N. Spectroscopic studies of trimetoxypropylsilane and bis(trimethoxysilyl)ethane sol-gel coatings on aluminum and copper. Spectrochim Acta A Mol Biomol Spectrosc. 2006;65:779-86 pubmed
    ..15M NaCl solution. The corresponding electronic circuit parameters have been determined to match the experimental EIS data. ..
  51. Lu H, Cheng J. N-Trimethylsilyl amines for controlled ring-opening polymerization of amino acid N-carboxyanhydrides and facile end group functionalization of polypeptides. J Am Chem Soc. 2008;130:12562-3 pubmed publisher
    ..Polypeptides formed by the N-TMS amine-mediated polymerization have the expected molecular weights, narrow molecular weight distributions, and controlled functional groups at the C-termini of the polypeptides...
  52. Wang X, Luo L, Ouyang G, Lin L, Tam N, Lan C, et al. One-step extraction and derivatization liquid-phase microextraction for the determination of chlorophenols by gas chromatography-mass spectrometry. J Chromatogr A. 2009;1216:6267-73 pubmed publisher
    ..7% (2,3,5,6-TeCP), and environmental water samples collected from the Pearl River were analyzed with the optimized LPME method, the concentrations of 18 CPs ranged from 0.0237microgL(-1) (3,5-DCP) to 0.3623microgL(-1) (2,3,6-TCP)...
  53. Chen J, Bennett M. Quantitation of orotic acid in urine using isotope dilution-selected ion gas chromatography-mass spectrometry. Methods Mol Biol. 2010;603:445-51 pubmed publisher
    ..Quantitation is made against an eight-point standard curve using specific selected ions from both the labeled and unlabeled orotic acid. ..
  54. Fujioka H, Senami K, Kubo O, Yahata K, Minamitsuji Y, Maegawa T. Mild deprotection of methylene acetals in combination with trimethylsilyl triflate-2,2'-bipyridyl. Chem Pharm Bull (Tokyo). 2010;58:426-8 pubmed
    ..The selective deprotection between methylene acetal and benzophenone ketal was achieved. ..
  55. Wu W, Zhang Z, Liebeskind L. In situ carboxyl activation using a silatropic switch: a new approach to amide and peptide constructions. J Am Chem Soc. 2011;133:14256-9 pubmed publisher
    ..Excellent stereoretention is observed. ..
  56. Pharikronburee V, Punirun T, Soorukram D, Kuhakarn C, Tuchinda P, Reutrakul V, et al. Fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to anhydrides: synthesis of ?-difluoromethylated ?-lactams. Org Biomol Chem. 2013;11:2022-33 pubmed publisher
  57. Chen J, Qin Y, Zhang M. [Determination of anabolic steroid hormones in animal muscle tissues by gas chromatography/mass spectrometry]. Se Pu. 2006;24:19-22 pubmed
    ..5% - 26.8%. The real sample tests showed this method can be used for the sensitive and accurate determination of multi-steroid anabolic hormones residues in biological muscle samples. ..
  58. Smith A, Xian M, Kim W, Kim D. The [1,5]-Brook rearrangement: an initial application in anion relay chemistry. J Am Chem Soc. 2006;128:12368-9 pubmed
    ..That the mode of silyl migration is intramolecular was demonstrated by a crossover experiment. Finally, the tricomponent anion relay chemistry (ARC) coupling tactic was demonstrated employing the [1,5]-Brook rearrangement. ..
  59. Parr M, Geyer H, Hoffmann B, Köhler K, Mareck U, Schanzer W. High amounts of 17-methylated anabolic-androgenic steroids in effervescent tablets on the dietary supplement market. Biomed Chromatogr. 2007;21:164-8 pubmed
    ..The quantitation of metandienone, norandrostenedione, and stanozolol was performed using HPLC-DAD. ..
  60. de Meijere A, Sokolov V, Yufit D, Panchenko Y, De Maré G, Abramenkov A, et al. Vibrational spectra and ab initio analysis of tert-butyl, trimethylsilyl, trimethylgermyl, trimethylstannyl and trimethylplumbyl derivatives of 3,3-dimethylcyclopropene. XII. 1,2-Di-tert-butyl-3,3-dimethylcyclopropene. Spectrochim Acta A Mol Biomol Spectrosc. 2010;75:1253-60 pubmed publisher
  61. Hope Jones M, Strydom P, Frylinck L, Webb E. The efficiency of electrical stimulation to counteract the negative effects of ?-agonists on meat tenderness of feedlot cattle. Meat Sci. 2010;86:699-705 pubmed publisher
    ..ES can therefore be implemented to improve meat tenderness in zilpaterol supplemented steers, although steers without zilpaterol will still have an advantage in final tenderness. ..
  62. Pieber B, Schober S, Goebl C, Mittelbach M. Novel sensitive determination of steryl glycosides in biodiesel by gas chromatography-mass spectroscopy. J Chromatogr A. 2010;1217:6555-61 pubmed publisher
    ..On the given conditions high recovery rates ? 89% can be obtained. Evaluation of lab specific variance and intermediate precision underline the robustness of the method which will be further assessed by Round robin tests. ..
  63. Uchiyama N, Ogata T, Oka N, Wada T. Trimethylsilyl trifluoromethanesulfonate-promoted reductive 2'-O-arylmethylation of ribonucleoside derivatives. Nucleosides Nucleotides Nucleic Acids. 2011;30:446-56 pubmed publisher
    ..Anomerization of the uridine derivatives by TMSOTf was observed in CH(2)Cl(2), toluene, and CH(3)CN, but was completely suppressed when the reactions were conducted in 1,4-dioxane. ..
  64. Ghassabian S, Wright L, Dejager A, Smith M. Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;881-882:34-41 pubmed publisher
    ..The validated assay method successfully quantified the concentrations of risedronate in plasma samples from informed consenting healthy volunteers administered a single 35 mg risedronate tablet. ..
  65. Battenberg O, Yang Y, Verhelst S, Sieber S. Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification. Mol Biosyst. 2013;9:343-51 pubmed publisher
    ..This modification results in inhibition of the amino acylation of tRNAs catalyzed by S. aureus STS which is an essential enzymatic pathway for bacterial viability. ..
  66. Rene A, Vanthuyne N, Martinez J, Cavelier F. (L)-(Trimethylsilyl)alanine synthesis exploiting hydroxypinanone-induced diastereoselective alkylation. Amino Acids. 2013;45:301-7 pubmed publisher
    ..Among the different synthetic routes that were tested including several chiral inductors and different Schiff bases, this strategy was selected and afforded (L)-TMSAla in good chemical overall yield with 98 % ee. ..
  67. Yamakita Y, Isogai Y, Ohno K. Large Raman-scattering activities for the low-frequency modes of substituted benzenes: induced polarizability and stereo-specific ring-substituent interactions. J Chem Phys. 2006;124:104301 pubmed
  68. Ito J, Ohki Y, Iwata M, Tatsumi K. Trithio-chloro molybdate [MoClS3]-: a versatile precursor for molybdenum trisulfido complexes. Inorg Chem. 2008;47:3763-71 pubmed publisher
    ..The molecular structures of 2, 6c, 7, 8a, 8b, 8c, and 9 were determined by X-ray crystallography. ..
  69. Harris R, Becker E, Cabral De Menezes S, Granger P, Hoffman R, Zilm K. Further conventions for NMR shielding and chemical shifts IUPAC recommendations 2008. Solid State Nucl Magn Reson. 2008;33:41-56 pubmed publisher
    ..The notation and terminology used for describing chemical shift and shielding tensors in solids are reviewed in some detail, and recommendations are given for best practice. ..
  70. Matinlinna J, Ozcan M, Lassila L, Kalk W, Vallittu P. Effect of the cross-linking silane concentration in a novel silane system on bonding resin-composite cement. Acta Odontol Scand. 2008;66:250-5 pubmed publisher
  71. Zhou Y, Zhou J, Xu Y, Zha J, Ma M, Wang Z. An alternative method for the determination of estrogens in surface water and wastewater treatment plant effluent using pre-column trimethylsilyl derivatization and gas chromatography/mass spectrometry. Environ Monit Assess. 2009;158:35-49 pubmed publisher
    ..6% to 121.1% with relative standard deviation of 1.5-4.7% for spiked effluent of WWTP. The results suggested that the optimized method provides a robust solution for the determination of trace steroid estrogens in complex matrix. ..
  72. Rathmann R, Mehaffey J, Baxa T, Nichols W, Yates D, Hutcheson J, et al. Effects of duration of zilpaterol hydrochloride and days on the finishing diet on carcass cutability, composition, tenderness, and skeletal muscle gene expression in feedlot steers. J Anim Sci. 2009;87:3686-701 pubmed publisher
    ..Furthermore, a ZH feeding duration of 20 d appeared to be adequate for capturing lean yield benefits while limiting tenderness losses. ..
  73. Benedito F, Petrenko T, Bill E, Weyhermüller T, Wieghardt K. Square planar bis{3,6-bis(trimethylsilyl)benzene-1,2-dithiolato}metal complexes of Cr(II), Co(III), and Rh(II): an experimental and density functional theoretical study. Inorg Chem. 2009;48:10913-25 pubmed publisher
  74. Vallejo A, Usobiaga A, Martinez Arkarazo I, Prieto A, Etxebarria N, Zuloaga O, et al. Ultrasonic-assisted derivatization of estrogenic compounds in a cup horn booster and determination by GC-MS. J Sep Sci. 2010;33:104-11 pubmed publisher
    ..52 ng/L) and the precision (0.2-5.3%) of the method were studied. This is the first work in the literature where a cup horn booster is used with the aim of minimizing derivatization time during the determination of estrogenic compounds. ..
  75. Veldboer K, Vielhaber T, Ahrens H, Hardes J, Streitburger A, Karst U. Determination of zoledronic acid in human urine and blood plasma using liquid chromatography/electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:2073-80 pubmed publisher
    ..The linear dynamic range comprised 3.5 decades starting at the limit of quantification. The method was successfully applied for the analysis of spiked urine and blood plasma samples as well as samples from two osteoporosis patients...
  76. Wei G, Chalker J, Cohen T. Synthesis of (-)-?-kainic acid via TMSCl-promoted Pd-catalyzed zinc-ene cyclization of an allyl acetate. J Org Chem. 2011;76:7912-7 pubmed publisher
  77. Saraiva D, Semedo R, Castilho M, Silva J, Ramos F. Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:3806-11 pubmed publisher
    ..92 to 3.91 CV and intermediate precision ranging from 5.12 to 6.33) and recoveries (?93.6%) were obtained. Thus, it proved to be a helpful methodology in the quantification of predominant serum cholesterol origin in each patient...
  78. Kosobokov M, Dilman A, Levin V, Struchkova M. Difluoro(trimethylsilyl)acetonitrile: synthesis and fluoroalkylation reactions. J Org Chem. 2012;77:5850-5 pubmed publisher
    ..The obtained silane served as a good cyanodifluoromethylating reagent toward aldehydes, N-tosylimines, N-alkylimines, and enamines under basic or acidic conditions. ..
  79. Boxer M, Yamamoto H. Triflimide (HNTf2)-catalyzed aldehyde cross-aldol reaction using "super silyl" enol ethers. Nat Protoc. 2006;1:2434-8 pubmed
    ..This reaction is catalyzed by 0.05 mol% of the Brønsted acid triflimide (HNTf2) and is complete within 15 min, making the protocol very attractive for large-scale synthesis. ..
  80. Adeuya A, Price N. Rapid characterization of polyalcohols by silylation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2007;21:3977-81 pubmed
    ..The number of observed peaks was used to confirm the number of hydroxyl groups in each analyte. ..
  81. Xiu Y, Hess D, Wong C. UV and thermally stable superhydrophobic coatings from sol-gel processing. J Colloid Interface Sci. 2008;326:465-70 pubmed publisher
    ..Contact angles remained >160 degrees with contact angle hysteresis approximately 2 degrees. ..
  82. Carro A, Gonzalez P, Fajar N, Lorenzo R, Cela R. Solid-phase micro-extraction procedure for the determination of 1,3-dichloro-2-propanol in water by on-fibre derivatisation with bis(trimethylsilyl)trifluoroacetamide. Anal Bioanal Chem. 2009;394:893-901 pubmed publisher
    ..1% for 10 ng mL(-1) and n = 5). The limits of detection and quantification were 0.4 and 1.4 ng mL(-1), respectively. Analytical recoveries obtained for different water samples were approx. 100%...
  83. Miao H, Fan S, Zhou P, Zhang L, Zhao Y, Wu Y. Determination of melamine and its analogues in egg by gas chromatography-tandem mass spectrometry using an isotope dilution technique. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010;27:1497-506 pubmed publisher
    ..05) were 4.9-8.4 and 3.6-9.5 µg kg(-1), respectively. The method was successfully applied to egg samples and milk products as well. Satisfactory results were obtained as part of the 2009 European Union melamine proficiency test. ..
  84. Pichardo J, Milner R, Bolch W. MRI measurement of bone marrow cellularity for radiation dosimetry. J Nucl Med. 2011;52:1482-9 pubmed publisher
    ..AVF provides the appropriate parameter to account for patient-specific cellularity in BM mass predictive equations and is consistent with current micro-CT-based models of skeletal dosimetry. ..
  85. Ibad M, Langer P, Reiß F, Schulz A, Villinger A. Catalytic trimerization of bis-silylated diazomethane. J Am Chem Soc. 2012;134:17757-68 pubmed publisher
    ..The kinetics and thermodynamics are discussed on the basis of DFT calculations...
  86. Lu Y, Nguyen P, Lévaray N, Lebel H. Palladium-catalyzed Saegusa-Ito oxidation: synthesis of ?,?-unsaturated carbonyl compounds from trimethylsilyl enol ethers. J Org Chem. 2013;78:776-9 pubmed publisher
    ..Cyclic and acyclic enones as well as ?,?-unsaturated aldehydes are obtained in good to excellent yields. ..
  87. Toriba A, Homma C, Kita M, Uozaki W, Boongla Y, Orakij W, et al. Simultaneous determination of polycyclic aromatic hydrocarbon quinones by gas chromatography-tandem mass spectrometry, following a one-pot reductive trimethylsilyl derivatization. J Chromatogr A. 2016;1459:89-100 pubmed publisher
    ..This method has the highest practicality in monitoring PAHQs in atmosphere, combustion exhaust gas, and toxicity evaluation. Thus, the method has the potential to become a standard analytical method for such applications. ..
  88. Moros G, Chatziioannou A, Gika H, Raikos N, Theodoridis G. Investigation of the derivatization conditions for GC-MS metabolomics of biological samples. Bioanalysis. 2017;9:53-65 pubmed
    ..Formation and stability of derivatives among metabolites differ greatly, so derivatization should be studied before application in metabolomics studies. ..
  89. de Oca Porto R, Pérez A, Correa Vidal M. Electron ionization mass spectra of ephedrines in a doping confirmatory procedure: a curious migration of the trimethylsilyl group in the N-acetyl-O-trimethylsilyl derivatives. Rapid Commun Mass Spectrom. 2007;21:1871-6 pubmed
    ..A curious migration of the trimethylsilyl group is proposed. ..
  90. Poisson T, Gembus V, Oudeyer S, Marsais F, Levacher V. Product-catalyzed addition of alkyl nitriles to unactivated imines promoted by sodium aryloxide/ethyl(trimethylsilyl)acetate (ETSA) combination. J Org Chem. 2009;74:3516-9 pubmed publisher
    ..The corresponding beta-amino nitriles are obtained in good to almost quantitative isolated yields under mild conditions. A mechanism involving an autocatalytic pathway is proposed on the basis of experimental observations. ..
  91. Allenbrand R, Garg U. Quantitation of homovanillic acid (HVA) and vanillylmandelic acid (VMA) in urine using gas chromatography-mass spectrometry (GC/MS). Methods Mol Biol. 2010;603:261-9 pubmed publisher
    ..The derivatized samples are injected to into gas-chromatograph mass spectrometer. The concentration of HVA and VMA is determined by comparing responses of unknown sample to the responses of calibrators using selected ion monitoring. ..
  92. Zhang B, Wee A. Di- and trisubstituted ?-lactams via Rh(II)-carbenoid reaction of N-C?-branched, N-bis(trimethylsilyl)methyl ?-diazoamides. Synthesis of (±)-?-allokainic acid. Org Lett. 2010;12:5386-9 pubmed publisher
    ..The synthesis of ?-allokainic acid demonstrates the utility of the method. ..