selenomethionine

Summary

Summary: Diagnostic aid in pancreas function determination.

Top Publications

  1. Xia Y, Hill K, Li P, Xu J, Zhou D, Motley A, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr. 2010;92:525-31 pubmed publisher
    ..subjects each were assigned randomly to daily dose groups of 0, 21, 35, 55, 79, 102, and 125 micro g Se as l-selenomethionine. Plasma glutathione peroxidase (GPX) activity, SEPP1, and selenium were measured...
  2. Gupta V, Gupta R, Khare G, Salunke D, Tyagi A. Crystal structure of Bfr A from Mycobacterium tuberculosis: incorporation of selenomethionine results in cleavage and demetallation of haem. PLoS ONE. 2009;4:e8028 pubmed publisher
    ..In addition, this study provides evidence against the general belief that a selenium derivative of a protein represents its true physiological native structure...
  3. McKenzie R, Beckett G, McLean S, Arthur J, Macve J, Nicol F, et al. Differential effects of doses and forms of dietary selenium on immune cell numbers in the skin of ultraviolet-irradiated and unirradiated mice. Biol Trace Elem Res. 2008;125:255-67 pubmed publisher
    The effect of three different doses of dietary L-selenomethionine (SM) and sodium selenite (SS) on skin selenium (Se) content, glutathione peroxidase (GPx) activity, Langerhans cell (LC) and mast cell numbers in ultraviolet radiation-B (..
  4. Santos R, Takahashi C. Anticlastogenic and antigenotoxic effects of selenomethionine on doxorubicin-induced damage in vitro in human lymphocytes. Food Chem Toxicol. 2008;46:671-7 pubmed
    ..The present study investigated the possible protective effects of selenomethionine (SM) on the cytotoxicity, genotoxicity and clastogenicity of the chemotherapic doxorubicin (DXR), a key ..
  5. Wang H, Zhang J, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic Biol Med. 2007;42:1524-33 pubmed
    ..b>Selenomethionine is considered to be the most appropriate supplemental form due to its excellent bioavailability and lower ..
  6. Ozten N, Horton L, Lasano S, Bosland M. Selenomethionine and alpha-tocopherol do not inhibit prostate carcinogenesis in the testosterone plus estradiol-treated NBL rat model. Cancer Prev Res (Phila). 2010;3:371-80 pubmed publisher
    ..In this study, we examined the potential of selenomethionine and alpha-tocopherol to modulate prostate cancer development in the testosterone plus estradiol-treated NBL ..
  7. Goel A, Fuerst F, Hotchkiss E, Boland C. Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cancer Biol Ther. 2006;5:529-35 pubmed
    ..However, the molecular mechanisms of action of selenomethionine, an organoselenium compound present in selenized yeast and currently being investigated in human clinical ..
  8. Malkowski M, Quartley E, Friedman A, Babulski J, Kon Y, Wolfley J, et al. Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Proc Natl Acad Sci U S A. 2007;104:6678-83 pubmed
    ..However, extensive replacement of methionine by selenomethionine for anomalous dispersion phasing has proven intractable in yeast...
  9. Krysiak R, Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto's thyroiditis. J Clin Endocrinol Metab. 2011;96:2206-15 pubmed publisher
    No previous study determined monocyte- and lymphocyte-suppressing effects of levothyroxine and selenomethionine and assessed whether their coadministration is superior to treatment with only one of these drugs...

More Information

Publications66

  1. Yan L, DeMars L. Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. Int J Cancer. 2012;131:1260-6 pubmed publisher
    ..investigated the effects of dietary supplementation with methylseleninic acid (MSeA), in comparison with selenomethionine (SeMet), on spontaneous metastasis of Lewis lung carcinoma (LLC) in male C57BL/6 mice using intramuscular and ..
  2. Barton W, Tzvetkova Robev D, Erdjument Bromage H, Tempst P, Nikolov D. Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells. Protein Sci. 2006;15:2008-13 pubmed
    ..advantage of the anomalous signal from diverse atoms, but the dominant method for derivative preparation is selenomethionine substitution...
  3. Sabichi A, Lee J, Taylor R, Thompson I, Miles B, Tangen C, et al. Selenium accumulation in prostate tissue during a randomized, controlled short-term trial of l-selenomethionine: a Southwest Oncology Group Study. Clin Cancer Res. 2006;12:2178-84 pubmed
    ..We conducted a randomized, controlled, short-term trial of l-selenomethionine (SeMet) versus observation in men with organ-confined prostate cancer...
  4. Krause R, Elfarra A. Reduction of L-methionine selenoxide to seleno-L-methionine by endogenous thiols, ascorbic acid, or methimazole. Biochem Pharmacol. 2009;77:134-40 pubmed publisher
    ..Furthermore, the novel reduction of MetSeO by methimazole provides clear evidence that methimazole should not be used as an alternative FMO substrate when studying FMO-mediated oxidation of SeMet. ..
  5. Lippman S, Klein E, Goodman P, Lucia M, Thompson I, Ford L, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39-51 pubmed publisher
    ..Oral selenium (200 microg/d from L-selenomethionine) and matched vitamin E placebo, vitamin E (400 IU/d of all rac-alpha-tocopheryl acetate) and matched selenium ..
  6. Madduri K, Badger M, Li Z, Xu X, Thornburgh S, Evans S, et al. Development of stable isotope and selenomethionine labeling methods for proteins expressed in Pseudomonas fluorescens. Protein Expr Purif. 2009;65:57-65 pubmed publisher
    ..in structure elucidation studies, the availability of target proteins labeled with stable isotopes or selenomethionine is essential for the determination of protein structures...
  7. Waters D, Shen S, Kengeri S, Chiang E, Combs G, Morris J, et al. Prostatic response to supranutritional selenium supplementation: comparison of the target tissue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasis. Nutrients. 2012;4:1650-63 pubmed publisher
    ..the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no such cancer-protective advantage using selenomethionine (SeMet)...
  8. Ohta Y, Kobayashi Y, Konishi S, Hirano S. Speciation analysis of selenium metabolites in urine and breath by HPLC- and GC-inductively coupled plasma-MS after administration of selenomethionine and methylselenocysteine to rats. Chem Res Toxicol. 2009;22:1795-801 pubmed publisher
    Selenium is an essential trace element found in vegetables as selenomethionine (SeMet) and methylselenocysteine (MeSeCys)...
  9. Goulet A, Watts G, Lord J, Nelson M. Profiling of selenomethionine responsive genes in colon cancer by microarray analysis. Cancer Biol Ther. 2007;6:494-503 pubmed
    ..Previous studies by our group demonstrated that selenomethionine-induced growth arrest appears to be mediated by activation of ERK and subsequent phosphorylation of RSK and ..
  10. Le D, Liang X, Fomenko D, Raza A, Chong C, Carlson B, et al. Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Biochemistry. 2008;47:6685-94 pubmed publisher
    ..Furthermore, we prepared a selenomethionine form of an MRP and found that selenomethionine selenoxide residues can be efficiently reduced ..
  11. Jung H, Lee J, Seo Y. Enhancement of methyl methanesulfonate-induced base excision repair in the presence of selenomethionine on p53-dependent pathway. J Med Food. 2009;12:340-4 pubmed publisher
    b>Selenomethionine (SeMet) has been identified as a chemopreventive antioxidant to activate p53-mediated nucleotide excision repair. In this study, we examined whether p53-mediated base excision repair (BER) might be induced by SeMet...
  12. Facompre N, El Bayoumy K, Sun Y, Pinto J, Sinha R. 1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells. Cancer Prev Res (Phila). 2010;3:975-84 pubmed publisher
    ..Our initial investigations show that the naturally occurring organoselenium compound selenomethionine (SM) and the synthetic 1,4-phenylenebis(methylene)selenocyanate (p-XSC) can inhibit human prostate cancer ..
  13. Suzuki M, Endo M, Shinohara F, Echigo S, Rikiishi H. Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells. Cancer Chemother Pharmacol. 2011;67:1129-36 pubmed publisher
    ..These results suggest that SeMet-induced apoptosis is affected by the Akt/mTOR/ROS pathway in A549 cells. Akt serves an anti-survival function in the system of SeMet-treated lung cancer cells, but autophagic signaling remained unsolved. ..
  14. Kim A, Oh J, Park J, Chung A. Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells. J Cell Physiol. 2007;212:386-400 pubmed
    ..In this study, we examine the effects of methylselenol generated from selenomethionine (SeMet) by methioninase (METase) on cell proliferation, adhesion, and expression of integrins in murine ..
  15. Goulet A, Chigbrow M, Frisk P, Nelson M. Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells. Carcinogenesis. 2005;26:109-17 pubmed
    b>Selenomethionine (SeMet) is being tested alone and in combination with other agents in cancer chemoprevention trials...
  16. Kim J, Sun P, Lam Y, Troncoso P, Sabichi A, Babaian R, et al. Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1697-702 pubmed
    Evidence of the chemopreventive effects of the dietary antioxidants alpha-tocopherol (vitamin E) and l-selenomethionine (selenium) comes from secondary analysis of two phase III clinical trials that found treatment with these antioxidants ..
  17. Limburg P, Wei W, Ahnen D, Qiao Y, Hawk E, Wang G, et al. Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib. Gastroenterology. 2005;129:863-73 pubmed
    ..We conducted a randomized, controlled trial of selenomethionine 200 microg daily and/or celecoxib 200 mg twice daily (2 x 2 factorial design) among residents of Linxian, ..
  18. Suzuki K, Doi C, Suzuki N. Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite. Toxicol Appl Pharmacol. 2006;217:185-95 pubmed
    Se-Methylated selenoamino acids, Se-methylselenocysteine (MeSeCys) and selenomethionine (SeMet), are chemically inert storage forms of selenium in selenium-accumulators, and a nutritional and supplemental source...
  19. Heinz G, Hoffman D, Klimstra J, Stebbins K. A comparison of the teratogenicity of methylmercury and selenomethionine injected into bird eggs. Arch Environ Contam Toxicol. 2012;62:519-28 pubmed publisher
    ..For all three species, selenomethionine alone caused more deformities than did methylmercury alone...
  20. dos Santos A, Mateus M, Carvalho C, Batoréu M. Biomarkers of exposure and effect as indicators of the interference of selenomethionine on methylmercury toxicity. Toxicol Lett. 2007;169:121-8 pubmed
    The present study was conducted to clarify the interference of selenomethionine (SeMet) on methylmercury (MeHg) toxicity through the evaluation of changes in biomarkers of exposure and effect in rats exposed to MeHg and co-exposed to MeHg ..
  21. Stewart J, Ko Y, Kennedy A. Protective effects of L-selenomethionine on space radiation induced changes in gene expression. Radiat Environ Biophys. 2007;46:161-5 pubmed
    ..studies are to characterize HZE particle radiation induced biological effects and evaluate the effects of L-selenomethionine (SeM) on these adverse biological effects...
  22. Li G, Lee H, Wang Z, Hu H, Liao J, Watts J, et al. Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite. Carcinogenesis. 2008;29:1005-12 pubmed publisher
    ..methylselenol precursors methylseleninic acid (MSeA) and Se-methylselenocysteine (MSeC) in comparison with selenomethionine (SeMet) and selenite in DU145 and PC-3 human PCa xenografts in athymic nude mice...
  23. Tiwary A, Stegelmeier B, Panter K, James L, Hall J. Comparative toxicosis of sodium selenite and selenomethionine in lambs. J Vet Diagn Invest. 2006;18:61-70 pubmed
    ..The objective of the study reported here was to compare the acute toxicosis caused by organic selenium (selenomethionine) found in plants with that caused by the supplemental, inorganic form of selenium (sodium selenite)...
  24. Misra S, Hamilton C, Niyogi S. Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss). Toxicol In Vitro. 2012;26:621-9 pubmed publisher
    Fish are exposed to environmental selenium predominantly in the form of dietary selenomethionine (SeMet)...
  25. Wan X, Ware J, Zhou Z, Donahue J, Guan J, Kennedy A. Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents. Int J Radiat Oncol Biol Phys. 2006;64:1475-81 pubmed
    ..concentrations of N-acetylcysteine, ascorbic acid, sodium ascorbate, co-enzyme Q10, alpha-lipoic acid, l-selenomethionine, and vitamin E succinate on radiation-induced oxidative stress were evaluated in MCF10 human breast ..
  26. Laible P, Hata A, Crawford A, Hanson D. Incorporation of selenomethionine into induced intracytoplasmic membrane proteins of Rhodobacter species. J Struct Funct Genomics. 2005;6:95-102 pubmed
    ..Development of methods for the in vivo substitution of methionine by selenomethionine (SeMet) has revolutionized the process for determination of structures of soluble proteins in recent years...
  27. Anastasilakis A, Toulis K, Nisianakis P, Goulis D, Kampas L, Valeri R, et al. Selenomethionine treatment in patients with autoimmune thyroiditis: a prospective, quasi-randomised trial. Int J Clin Pract. 2012;66:378-83 pubmed publisher
    ..To test whether selenium administration affects autoantibodies to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-TG) titres in chronic autoimmune (Hashimoto's - HT) thyroiditis...
  28. Kaur P, Evje L, Aschner M, Syversen T. The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity. Toxicol In Vitro. 2009;23:378-85 pubmed publisher
    ..Therefore, we investigated whether 24h. preincubation or 50min. coincubation with selenomethionine (SeMet) was effective in reducing methylmercury (MeHg)-induced cytotoxicity in C6-glioma and B35-neuronal ..
  29. Berntsson R, Alia Oktaviani N, Fusetti F, Thunnissen A, Poolman B, Slotboom D. Selenomethionine incorporation in proteins expressed in Lactococcus lactis. Protein Sci. 2009;18:1121-7 pubmed publisher
    ..Here, we describe a protocol for incorporation of selenomethionine (SeMet) into proteins expressed in L. lactis...
  30. Duntas L. Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab. 2010;95:5180-8 pubmed publisher
    ..Maintenance of "selenostasis" via optimal intake not only aids preservation of general health but also contributes substantially to the prevention of thyroid disease. ..
  31. Miranda S, Wang Y, Purdie N, Osborne V, Coomber B, Cant J. Selenomethionine stimulates expression of glutathione peroxidase 1 and 3 and growth of bovine mammary epithelial cells in primary culture. J Dairy Sci. 2009;92:2670-83 pubmed publisher
    ..The effect of selenium as selenomethionine (SeMet) on the growth and viability of BMEC and GPx protein expression and activity were also studied...
  32. Laffon B, Valdiglesias V, Pasaro E, Mendez J. The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes. Biol Trace Elem Res. 2010;133:12-9 pubmed publisher
    The objective of this work was to evaluate the effects of selenomethionine (SeMet) on the induction, repair, and persistence of DNA damage in human leukocytes challenged with bleomycin (BLM)...
  33. Thomas J, Janz D. Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response. Aquat Toxicol. 2011;102:79-86 pubmed publisher
    b>Selenomethionine (Se-Met) is the major form of organoselenium present in food...
  34. Cheng A, Stabler T, Bolognesi M, Kraus V. Selenomethionine inhibits IL-1? inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. Osteoarthritis Cartilage. 2011;19:118-25 pubmed publisher
    ..Isolated primary human chondrocytes were pretreated with selenomethionine (SeMet) (0...
  35. Jung H, Kim H, Kim Y, Weon J, Seo Y. A novel chemopreventive mechanism of selenomethionine: enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair. Oncol Rep. 2013;30:1581-6 pubmed publisher
    ..Our previous study showed that selenomethionine (SeMet) induces p53 activation without genotoxic effects including apoptosis and cell cycle arrest...
  36. Yang Y, Huang F, Ren Y, Xing L, Wu Y, Li Z, et al. The anticancer effects of sodium selenite and selenomethionine on human colorectal carcinoma cell lines in nude mice. Oncol Res. 2009;18:1-8 pubmed
    ..to evaluate the chemotherapeutic potential of selenium containing compounds such as sodium selenite (SSe) and selenomethionine (SeMet). Three doses of anticancer drugs were used, including 0...
  37. Iwaoka M, Ooka R, Nakazato T, Yoshida S, Oishi S. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008;5:359-74 pubmed publisher
    ..our recent progresses in the transformation from sulfur-containing amino acids to selenocysteine (SeCys) and selenomethionine (SeMet) derivatives are reviewed along with the surveys of general organic methodologies for the synthesis of ..
  38. Vergara A, Merlino A, Pizzo E, D Alessio G, Mazzarella L. A novel method for detection of selenomethionine incorporation in protein crystals via Raman microscopy. Acta Crystallogr D Biol Crystallogr. 2008;64:167-71 pubmed publisher
    ..Mass spectrometry is currently used to evaluate the selenomethionine (SeMet) content in solution, but excluding fluorescence spectroscopy at the absorption edge, no other routine ..
  39. Larsson A, Jones T. Selenomethionine labeling of recombinant proteins. Methods Mol Biol. 2007;389:165-74 pubmed
    b>Selenomethionine incorporation is a standard method for determining the phases in protein crystallography by single- or multiwavelength anomalous dispersion...
  40. McSheehy S, Yang L, Sturgeon R, Mester Z. Determination of methionine and selenomethionine in selenium-enriched yeast by species-specific isotope dilution with liquid chromatography-mass spectrometry and inductively coupled plasma mass spectrometry detection. Anal Chem. 2005;77:344-9 pubmed
    b>Selenomethionine (SeMet) and methionine (Met), liberated by acid hydrolysis of selenium-enriched yeast, were quantified by liquid chromatography-mass spectrometry (LC/MS) using standard additions calibrations as well as isotope dilution (..
  41. Weber D, Connaughton V, Dellinger J, Klemer D, Udvadia A, Carvan M. Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiol Behav. 2008;93:250-60 pubmed
    ..0-0.30 microM MeHg and/or selenomethionine (SeMet) until 24 hpf then placed in clean medium...
  42. Andriamanalijaona R, Kypriotou M, Bauge C, Renard E, Legendre F, Raoudi M, et al. Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes. J Rheumatol. 2005;32:1958-67 pubmed
    To determine the effects of selenomethionine (Se-met) and epigallocatechin-gallate (EGCg) on gene expression, activation of mitogen-activating kinases, and DNA binding of nuclear factor-kappaB (NF-kappaB) and apolipoprotein-1 (AP-1) in ..
  43. Vega L, Rodriguez Sosa M, García Montalvo E, Del Razo L, Elizondo G. Non-optimal levels of dietary selenomethionine alter splenocyte response and modify oxidative stress markers in female mice. Food Chem Toxicol. 2007;45:1147-53 pubmed
    Many studies evaluating the effects of selenium (Se) status on immunity utilize inorganic Se, although selenomethionine (Se-Met) has been suggested to be more bioavailable and less toxic...
  44. Combs G, Midthune D, Patterson K, Canfield W, Hill A, Levander O, et al. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr. 2009;89:1808-14 pubmed publisher
    ..Twenty-eight healthy adults took 200 microg selenomethionine/d for 28 mo...
  45. Cherukuri D, Goulet A, Inoue H, Nelson M. Selenomethionine regulates cyclooxygenase-2 (COX-2) expression through nuclear factor-kappa B (NF-kappaB) in colon cancer cells. Cancer Biol Ther. 2005;4:175-80 pubmed
    Previously, we showed that selenomethionine (Se-Met) inhibits growth of colon cancer cells via suppressing COX-2 expression at both mRNA and protein level...
  46. Fakih M, Pendyala L, Smith P, Creaven P, Reid M, Badmaev V, et al. A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors. Clin Cancer Res. 2006;12:1237-44 pubmed
    ..a phase I study to determine the maximum tolerated dose (MTD) of irinotecan with fixed, nontoxic high dose of selenomethionine. Selenomethionine was given orally as a single daily dose containing 2,200 mug of elemental selenium (Se) ..
  47. Martinez J, Lisa S, Sanchez R, Kowalczyk W, Zurita E, Teixido M, et al. Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity. PLoS ONE. 2011;6:e27999 pubmed publisher
    ..fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties...
  48. Holton J. XANES measurements of the rate of radiation damage to selenomethionine side chains. J Synchrotron Radiat. 2007;14:51-72 pubmed
    The radiation-induced disordering of selenomethionine (SeMet) side chains represents a significant impediment to protein structure solution...
  49. Combs G, Jackson M, Watts J, Johnson L, Zeng H, Idso J, et al. Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. Br J Nutr. 2012;107:1514-25 pubmed publisher
    ..to characterise the responses of multiple biomarkers of Se status in healthy American adults to supplemental selenomethionine (SeMet) and to identify factors affecting those responses...
  50. Mazokopakis E, Papadakis J, Papadomanolaki M, Batistakis A, Giannakopoulos T, Protopapadakis E, et al. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Thyroid. 2007;17:609-12 pubmed
    ..All patients received 200 microg Se in the form of l-selenomethionine orally for 6 months...
  51. Wang X, Tipton J, Emmett M, Marshall A. Sites and extent of selenomethionine incorporation into recombinant Cas6 protein by top-down and bottom-up proteomics with 14.5 T Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2010;24:2386-92 pubmed publisher
    b>Selenomethionine-modified proteins can improve X-ray crystallographic structural resolution by multi-wavelength anomalous diffraction (MAD) phasing...
  52. Wang H, Riahi M, Pothen J, Bayse C, Riggs Gelasco P, Brumaghim J. Interactions of Cu(I) with selenium-containing amino acids determined by NMR, XAS, and DFT studies. Inorg Chem. 2011;50:10893-900 pubmed publisher
    ..selenium antioxidant activity, Cu(I) coordination of the selenoamino acids methyl-Se-cysteine (MeSeCys) and selenomethionine (SeMet) was investigated...
  53. Schwartz T, Kmiec E. Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides. BMC Mol Biol. 2007;8:7 pubmed
    ..In this report, we find that addition of selenomethionine reduces gene repair frequency in a dose-dependent fashion...
  54. Traynor N, McKenzie R, Beckett G, Gibbs N. Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photoimmunol Photomed. 2006;22:297-303 pubmed
    ..We examined whether selenomethionine could protect human skin cells from UV radiation-induced p53 transactivation, using a pRGCDeltafos-lacZ p53-..
  55. Xiong S, Markesbery W, Shao C, Lovell M. Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron death. Antioxid Redox Signal. 2007;9:457-67 pubmed
  56. Weekley C, Aitken J, Vogt S, Finney L, Paterson D, de Jonge M, et al. Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods. Biochemistry. 2011;50:1641-50 pubmed publisher
    ..The uptake, speciation, and distribution of the common selenoamino acid supplements, selenomethionine (SeMet) and Se-methylselenocysteine (MeSeCys), in A549 human lung cancer cells were investigated using X-ray ..
  57. Moreno F, García Barrera T, Gomez Ariza J. Simultaneous analysis of mercury and selenium species including chiral forms of selenomethionine in human urine and serum by HPLC column-switching coupled to ICP-MS. Analyst. 2010;135:2700-5 pubmed publisher
    ..and analyzing different selenium and mercury species (Se-methylselenocysteine, selenite, selenate, L-selenomethionine, D-selenomethionine, methylmercury and inorganic mercury)...