fosinopril

Summary

Summary: A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

Top Publications

  1. Fogari R, Preti P, Zoppi A, Rinaldi A, Corradi L, Pasotti C, et al. Effects of amlodipine fosinopril combination on microalbuminuria in hypertensive type 2 diabetic patients. Am J Hypertens. 2002;15:1042-9 pubmed
    The aim of this study is to compare the long-term effect of amlodipine and fosinopril in monotherapy or in combination on urinary albumin excretion (UAE) in hypertensive diabetic patients...
  2. Cremonesi G, Cavalieri L, Cikes I, Dobovisek J, Bacchelli S, Degli Esposti D, et al. Fixed combinations of delapril plus indapamide vs fosinopril plus hydrochlorothiazide in mild to moderate essential hypertension. Adv Ther. 2002;19:129-37 pubmed
    ..5 mg and fosinopril (F) 20 mg plus hydrochlorothiazide (H) 12...
  3. van der Harst P, Asselbergs F, Hillege H, Voors A, van Veldhuisen D, van Gilst W. Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria. Am J Cardiol. 2008;102:223-5 pubmed publisher
    ..The aim of this study was to test the hypothesis that angiotensin-converting enzyme inhibition with fosinopril would reduce inflammation in a placebo-controlled trial involving 621 subjects...
  4. Zannad F, Kessler M, Lehert P, Grunfeld J, Thuilliez C, Leizorovicz A, et al. Prevention of cardiovascular events in end-stage renal disease: results of a randomized trial of fosinopril and implications for future studies. Kidney Int. 2006;70:1318-24 pubmed
    ..The study objective was to evaluate the effect of fosinopril on CVEs in patients with ESRD...
  5. Sarro G, Paola E, Gratteri S, Gareri P, Rispoli V, Siniscalchi A, et al. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacol Res. 2012;65:285-96 pubmed publisher
    ..was to evaluate the effects of some angiotensin-converting enzyme inhibitors (ACEi; captopril, enalapril, fosinopril and zofenopril), commonly used as antihypertensive agents, in the DBA/2 mice animal model of generalized tonic-..
  6. Asselbergs F, Diercks G, Hillege H, van Boven A, Janssen W, Voors A, et al. Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria. Circulation. 2004;110:2809-16 pubmed
    ..Of these subjects, 864 were randomized to fosinopril 20 mg or matching placebo and to pravastatin 40 mg or matching placebo...
  7. Beck L, Blanc Guillemaud V, Cherif O, Jover B, Davy J. Effects of spironolactone and fosinopril on the spontaneous and chronic ventricular arrhythmias in a rat model of myocardial infarction. Cardiology. 2001;96:85-93 pubmed
    ..in a first group of 58 rats after myocardial infarction (MI), then assessed the effects of spironolactone and fosinopril on morphological indexes and arrhythmias in a second group (n = 33)...
  8. Asselbergs F, Van Roon A, Hillege H, de Jong P, Gans R, Smit A, et al. Effects of fosinopril and pravastatin on carotid intima-media thickness in subjects with increased albuminuria. Stroke. 2005;36:649-53 pubmed
    ..as well as statins have been shown to lower UAE and the progression of IMT, we assessed the effects of fosinopril and pravastatin on carotid IMT in subjects with an increased UAE (15 to 300 mg/24 h)...
  9. Zhang W, Chen X, Shi S, Wei R, Wang J, Yamanaka N, et al. Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril. Nephrol Dial Transplant. 2005;20:892-901 pubmed
    ..modified chronic immune complex glomerulonephritis, and that angiotensin-converting enzyme (ACE) inhibition with fosinopril may prevent the activation of STAT3 and subsequent upregulation of tissue inhibitor of metalloproteinase-1 (TIMP-..

More Information

Publications62

  1. Gasic S, Wagner O, Fasching P, Ludwig C, Veitl M, Kapiotis S, et al. Fosinopril decreases levels of soluble vascular cell adhesion molecule-1 in borderline hypertensive type II diabetic patients with microalbuminuria. Am J Hypertens. 1999;12:217-22 pubmed
    ..b>Fosinopril (10 mg/day) was administered over 12 weeks to 11 microalbuminuric patients with non-insulin-dependent diabetes ..
  2. Menon S, Berezny K, Kilaru R, Benjamin D, Kay J, Hazan L, et al. Racial differences are seen in blood pressure response to fosinopril in hypertensive children. Am Heart J. 2006;152:394-9 pubmed
    ..enrolled at 78 clinical sites in the US, Russia, and Israel in a double blind study to evaluate the efficacy of fosinopril compared to placebo. The racial composition of the cohort included 60.1% white (152/253), 20...
  3. Pool J, Cushman W, Saini R, Nwachuku C, Battikha J. Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension. Am J Hypertens. 1997;10:117-23 pubmed
    ..double-blind, placebo-controlled, parallel group design to study the efficacy of 17 different doses of fosinopril (Fos), a phosphinic acid derived ACE inhibitor, and hydrochlorothiazide (HCTZ) in 550 patients with mild to ..
  4. Bilge A, Atilgan D, Tukek T, Ozcan M, Ozben B, Koylan N, et al. Effects of amlodipine and fosinopril on heart rate variability and left ventricular mass in mild-to-moderate essential hypertension. Int J Clin Pract. 2005;59:306-10 pubmed
    ..We studied the long-term effects of amlodipine and fosinopril on 24-h HRV and LV mass in mild-to-moderate essential hypertension...
  5. Meng Y, Zhang Z, Liang X, Wu C, Qi G. Effects of combination therapy with amlodipine and fosinopril administered at different times on blood pressure and circadian blood pressure pattern in patients with essential hypertension. Acta Cardiol. 2010;65:309-14 pubmed
    The objective of our study was to compare the effects of a combination therapy with amlodipine and fosinopril administered concomitantly or at different times on blood pressure and circadian blood pressure pattern in subjects with ..
  6. Brouwers F, Asselbergs F, Hillege H, de Boer R, Gansevoort R, van Veldhuisen D, et al. Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria:Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT). Am Heart J. 2011;161:1171-8 pubmed publisher
    ..We obtained extended follow-up data to approximately 10 years to investigate the long-term effects of fosinopril 20 mg and pravastatin 40 mg on cardiovascular outcomes in subjects with UAE >15 mg per 24 hours...
  7. Yu G, Liang X, Xie X, Su M, Zhao S. Diverse effects of chronic treatment with losartan, fosinopril, and amlodipine on apoptosis, angiotensin II in the left ventricle of hypertensive rats. Int J Cardiol. 2001;81:123-9; discussion 129-30 pubmed
    ..of angiotensin II (AngII) type I receptor antagonists, losartan, angiotensin converting enzyme (ACE) inhibitors, fosinopril, and calcium channel blockade, amlodipine on cardiomyocyte apoptosis and AngII in the left ventricle of ..
  8. Zanchetti A, Crepaldi G, Bond M, Gallus G, Veglia F, Mancia G, et al. Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind tr. Stroke. 2004;35:2807-12 pubmed
    ..Lipid-Lowering Italian Study (PHYLLIS) tested whether (1) the angiotensin-converting enzyme (ACE) inhibitor fosinopril (20 mg per day) was more effective on carotid atherosclerosis progression than the diuretic hydrochlorothiazide (..
  9. Li J, Berezny K, Kilaru R, Hazan L, Portman R, Hogg R, et al. Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?. Hypertension. 2004;44:289-93 pubmed
    We evaluated the efficacy, safety, and dose-response relationship of fosinopril in children aged 6 to 16 years with hypertension or high-normal blood pressure with an associated medical condition requiring treatment...
  10. Zhao J, Yang Y, You S, Jing Z, Wu Y, Cheng J, et al. Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Coron Artery Dis. 2006;17:463-9 pubmed
    Both fosinopril and valsartan are effective in protecting endothelial function. We hypothesized that they may also reduce myocardial no-reflow...
  11. Yu C, Wing Hon Lai K, Li P, Lam K, Leung J, Lai K. Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action. J Mol Cell Cardiol. 2004;36:445-53 pubmed
    This study investigated the effect of fosinopril (Fos), valsartan (Val), and combination of both drugs (Fos + Val) on the cardiac and renal expression of aquaporin-1 (AQP1) and aquaporin-2 (AQP2) in congestive heart failure (CHF)...
  12. Pouwels K, Visser S, Hak E. Effect of pravastatin and fosinopril on recurrent urinary tract infections. J Antimicrob Chemother. 2013;68:708-14 pubmed publisher
    ..Animal experiments and in vitro studies indicate that statins might prevent recurrent UTIs. We assessed the effects of pravastatin on UTI antibiotic prescribing among adults...
  13. Angulo E, Robles N, Grois J, Barquero A, Perez Miranda M. [Comparison of the antihypertensive activity of fosinopril and irbesartan]. An Med Interna. 2002;19:571-5 pubmed
    ..2 +/- 8.7 years, 9 men and 6 women) or fosinopril (20 mg once daily) (n = 15, mean age 57.4 +/- 11...
  14. Villa E, Rabano A, Ruilope L, Garcia Robles R. Effects of cicaprost and fosinopril on the progression of rat diabetic nephropathy. Am J Hypertens. 1997;10:202-8 pubmed
    We have studied the effects of chronic therapy with cicaprost (a PGI2 analog), fosinopril (a converting enzyme inhibitor), and the combination of both drugs on the progression of experimental diabetic nephropathy...
  15. Kavgaci H, Sahin A, Onder Ersoz H, Erem C, Ozdemir F. The effects of losartan and fosinopril in hypertensive type 2 diabetic patients. Diabetes Res Clin Pract. 2002;58:19-25 pubmed
    ..Twenty patients were randomized to receive 50 mg/day losartan and 13 patients to 10 mg/day fosinopril. Patients were studied at baseline and after 1 and 6 months...
  16. Pahor M, Franse L, Deitcher S, Cushman W, Johnson K, Shorr R, et al. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation. 2002;105:457-61 pubmed
    ..mellitus (n=96, 51% black) were randomized after an initial 4 weeks of placebo to double-blind 20 or 40 mg fosinopril or 5 or 10 mg amlodipine daily for 4 weeks in a fixed-dose regimen...
  17. Atthobari J, Asselbergs F, Boersma C, de Vries R, Hillege H, van Gilst W, et al. Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of r. Clin Ther. 2006;28:432-44 pubmed
    ..The PREVEND IT study was conducted to assess the effects of fosinopril 20 mg and pravastatin 40 mg on CVEs in subjects with specific inclusion criteria: urinary albumin excretion (UAE)..
  18. Maniu C, Meyer D, Redfield M. Hemodynamic and humoral effects of vasopeptidase inhibition in canine hypertension. Hypertension. 2002;40:528-34 pubmed
    ..Neither an equimolar dose of an ACE inhibitor (fosinopril) nor exogenous adrenomedullin had as potent of a hypotensive effect, and neither reduced preload...
  19. Haenni A, Berglund L, Reneland R, Anderssson P, Lind L, Lithell H. The alterations in insulin sensitivity during angiotensin converting enzyme inhibitor treatment are related to changes in the calcium/magnesium balance. Am J Hypertens. 1997;10:145-51 pubmed
    ..The serum ACE activity was determined in the group treated with fosinopril. Changes in insulin sensitivity index (M/I) were directly correlated to alterations in S-Mg (r = 0.24, P < ...
  20. Giovannini S, Cesari M, Marzetti E, Leeuwenburgh C, Maggio M, Pahor M. Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile. J Nutr Health Aging. 2010;14:457-60 pubmed
    The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease...
  21. Guo J, Li L, Qiu G, Deng Z, Fu Y, Yang M, et al. [Effects of Panax notoginseng saponins on ACE2 and TNF-alpha in rats with post-myocardial infarction-ventricular remodeling]. Zhong Yao Cai. 2010;33:89-92 pubmed
    ..the rats were randomly divided into control and experiment groups, then respectively administrated with NS, fosinopril and low, middle and high dosage of PNS for four consecutive weeks...
  22. García Testal A, Monzo A, Rabanaque G, Gonzalez A, Romeu A. [Evolution of the bone mass of hypertense menopausal women in treatment with fosinopril]. Med Clin (Barc). 2006;127:692-4 pubmed
    ..of non hypertense patients and one cohort of hypertense women who initiated antihypertensive treatment with oral fosinopril. Baseline and after 1 year bone mineral density of lumbar spine and femoral neck was made...
  23. He H, Wang W, Zhang H, Ma L, Wu H, Wang P, et al. Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. Cardiovasc Drugs Ther. 2006;20:259-71 pubmed
    ..of Protein Kinase C epsilon (PKC epsilon) and components of its signaling complexes after treatment with fosinopril and carvedilol and analyze potential molecular mechanisms of the two drugs for cardiac hypertrophy and heart ..
  24. MacFadyen R, Lee A, Morton J, Pringle S, Struthers A. How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure?. Heart. 1999;82:57-61 pubmed
    ..A representative range of ACE inhibitors (enalapril, lisinopril, captopril, perindopril, and fosinopril) was examined. Supine measurements showed a wide range of AII (10.5 (25.5) pg/ml), aldosterone (130...
  25. Zhang L, Ma J, Gu Y, Lin S. Effects of blocking the renin-angiotensin system on expression and translocation of protein kinase C isoforms in the kidney of diabetic rats. Nephron Exp Nephrol. 2006;104:e103-11 pubmed
    ..Our study focused on the effects of angiotensin blockade, using the angiotensin-converting enzyme inhibitor fosinopril, the Ang II receptor blocker irbesartan and their combination, on the expression and translocation of PKC ..
  26. Tong P, Ko G, Chan W, Ma R, So W, Lo M, et al. The efficacy and tolerability of fosinopril in Chinese type 2 diabetic patients with moderate renal insufficiency. Diabetes Obes Metab. 2006;8:342-7 pubmed
    ..We examined the efficacy and tolerability of fosinopril, an ACE inhibitor with dual hepatic and renal clearance, in 38 type 2 diabetic patients with moderate renal ..
  27. Korshunov V, Massett M, Carey R, Berk B. Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling. J Vasc Res. 2004;41:148-56 pubmed
    ..We compared the effects of omapatrilat (40 mg/kg/day, p.o.) to fosinopril (40 mg/kg/day, p.o.) on flow-induced vascular remodeling in New Zealand genetically hypertensive (GH) rats...
  28. Waldemar G, Ibsen H, Strandgaard S, Andersen A, Rasmussen S, Paulson O. The effect of fosinopril sodium on cerebral blood flow in moderate essential hypertension. Am J Hypertens. 1990;3:464-70 pubmed
    The effect of the angiotensin converting enzyme (ACE) inhibitor fosinopril sodium on regional cerebral blood flow (rCBF) was investigated in 8 patients with moderate essential hypertension...
  29. Yu G, Liang X, Xie X, Yang T, Sun M, Zhao S. Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan. Chin Med J (Engl). 2002;115:1287-91 pubmed
    ..II type 1 (AT(1)) receptor antagonist, losartan, and an angiotensin converting enzyme (ACE) inhibitor, fosinopril, on cardiomyocyte apoptosis, myocardial fibrosis, and angiotensin II (Ang II) in the left ventricle of ..
  30. Huang Y, Wang H, Zhu Q, Zhang H, Shen W, Wang Y. [Combination therapy with losartan and fosinopril for early diabetic nephropathy]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23:963-5 pubmed
    To observe the effects of combined use of losartan and fosinopril in the treatment of early diabetic nephropathy...
  31. Yeung E, Wong F, Wanless I, Shiota K, Guindi M, Joshi S, et al. Ramipril-associated hepatotoxicity. Arch Pathol Lab Med. 2003;127:1493-7 pubmed
    ..hepatic events, especially cholestasis, have rarely been reported with captopril, enalapril, lisinopril, and fosinopril. To date, hepatic injury associated with ramipril has not been reported...
  32. Baraka M, El Sadek M, Moussa E, Abd Alaty N. Spectrophotometric and atomic absorption determination of ramipril, enalapril maleate and fosinopril through ternary complex formation with molybdenum (V)-thiocyanate (Mo(V)-SCN). Chem Pharm Bull (Tokyo). 2008;56:1521-7 pubmed
    ..for the determination of three angiotensin-converting enzyme inhibitors, namely, ramipril, enalapril maleate and fosinopril. The first two spectrophotometric (extractive and non-extractive) procedures were based on ternary complex ..
  33. Filigheddu F, Argiolas G, Bulla E, Troffa C, Bulla P, Fadda S, et al. Clinical variables, not RAAS polymorphisms, predict blood pressure response to ACE inhibitors in Sardinians. Pharmacogenomics. 2008;9:1419-27 pubmed publisher
    ..and anthropometric variables, intermediate phenotypes and gene polymorphisms with blood pressure after fosinopril in a genetically homogeneous cohort...
  34. Zheng Z, Chen H, Xu X, Li C, Gu Q. Effects of angiotensin-converting enzyme inhibitors and beta-adrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy. Exp Eye Res. 2007;84:745-52 pubmed
    ..beta-adrenergic blockers had no influence on retinal VEGF expression in normal or diabetic rats. ..
  35. Buranakarl C, Kitjtawonrat A, Pondeenana S, Sunyasujaree B, Kanchanapangka S, Chaiyabutr N, et al. Comparison of dipyridamole and fosinopril on renal progression in nephrectomized rats. Nephrology (Carlton). 2003;8:80-91 pubmed
    ..In the present study, dipyridamole (DPM; 30 mg/kg per day, p.o.) or fosinopril (FOS; 20 mg/kg per day, p.o...
  36. Szucs T. Pharmacoeconomics of angiotensin converting enzyme inhibitors in heart failure. Am J Hypertens. 1997;10:272S-279S pubmed
    ..In addition, analysis of more recent studies of the treatment of fosinopril in patients with mild to moderate CHF have been performed and have proved this newer ACE inhibitor to be cost-..
  37. Parodi A, Cozzani E, Milesi G, Drosera M, Rebora A. Fosinopril as a possible pemphigus-inducing drug. Dermatology. 2002;204:139-41 pubmed
    b>Fosinopril has recently been added to the angiotensin-converting enzyme inhibitors inducing pemphigus...
  38. Hale L, Craver K, Berrier A, Sheffield M, Case L, Owen J. Combination of fosinopril and pravastatin decreases platelet response to thrombin receptor agonist in monkeys. Arterioscler Thromb Vasc Biol. 1998;18:1643-6 pubmed
    ..by alteration in platelet reactivity, we studied 55 monkeys receiving both, 1, or neither of the ACE inhibitor fosinopril and the HMG-CoA reductase inhibitor pravastatin...
  39. Oudit G, Girgrah N, Allard J. ACE inhibitor-induced angioedema of the intestine: Case report, incidence, pathophysiology, diagnosis and management. Can J Gastroenterol. 2001;15:827-32 pubmed
    A case report of fosinopril-induced angioedema of the intestine with a chronic course accompanied by multiple acute exacerbations is described...
  40. Dong Y, Zhou H, Shaffer E, Atamas N, Liao W, Wei C. The cardiovascular actions of omapatrilat in spontaneously hypertensive rats. Curr Hypertens Rep. 2001;3 Suppl 2:S1-5 pubmed
    ..Studies were performed in SHR that received vehicle (n = 9), omapatrilat (n = 10), or fosinopril (ACE inhibitor, n = 7) by daily gavage for 56 days...
  41. Vershinina A, Gapon L, Veber E, Popova S, Pliusnin A. [Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia]. Ter Arkh. 2005;77:55-8 pubmed
    To study effects of fosinopril on a 24-h profile of blood pressure (BP) in hypertensive patients with obesity and hypercholesterolemia...
  42. Shu C, Shen H, Hopfer U, Smith D. Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001;29:1307-15 pubmed
    The objective of this study was to delineate the transepithelial transport mechanisms of fosinopril in cultured cell lines expressing the intestinal and renal peptide transporters...
  43. Kalisz D, Dabrowski Z, Kakol B, Bełdowicz M, Obukowicz B, Kamiński J. Synthesis of optically active trans 4-cyclohexyl-L-proline as an intermediate product in the preparation of fosinopril. Acta Pol Pharm. 2005;62:121-6 pubmed
    ..The product is an intermediate in the preparation of fosinopril--an effective hypotensive drug. The total yield of the synthesis was 25%. The final product was 99.7% pure...
  44. Cao Z, Burrell L, Tikkanen I, Bonnet F, Cooper M, Gilbert R. Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats. Kidney Int. 2001;60:715-21 pubmed
    ..at a low dose of 10 mg/kg (L, N = 12) and at a high dose of 40 mg/kg (H, N = 10); or an ACE inhibitor, fosinopril, at a dose of 10 mg/kg (N = 12). Sham-operated rats were used as control animals (N = 12)...
  45. Borghi C, Bacchelli S, Ambrosioni E. The use of zofenopril and fosinopril in acute myocardial infarction and carotid artery disease. Am J Hypertens. 1994;7:96S-101S pubmed
    ..evaluated in PHYLLIS (Plaque HYpertension Lipid Lowering Italian Study), a multicenter clinical trial in which fosinopril sodium, a new ACE inhibitor, is administered to hypertensive patients with at least one uncomplicated carotid ..
  46. Agaev M, Azizov V. [Efficacy of combined use of fosinopril and propranolol in acute myocardial infarction]. Kardiologiia. 2003;43:29-34 pubmed
    ..30-70 years with first anterior Q-wave myocardial infarction (MI) for the study of effects of combination of fosinopril and propranolol (20 patients) in comparison with propranolol alone (20 patients) on hemodynamics and size of ..
  47. Eledrisi M, Alamoudi R. For potential resolution of cough associated with an angiotensin-converting enzyme inhibitor. Endocr Pract. 2005;11:70 pubmed
  48. Tiryaki O, Usalan C, Buyukhatipoglu H. Effect of combined angiotensin-converting enzyme and aldosterone inhibition on plasma plasminogen activator inhibitor type 1 levels in chronic hypertensive patients. Nephrology (Carlton). 2010;15:211-5 pubmed publisher
    ..Patients were randomized into two groups and were treated with either low salt diet plus fosinopril (group 1, n = 43) or low salt diet plus fosinopril plus spironolactone (group 2, n = 42)...
  49. Taskapilioglu O, Karli N, Erer S, Zarifoglu M, Bakar M, Turan F. Primary gait ignition disorder: report of three cases. Neurol Sci. 2009;30:333-7 pubmed publisher
    ..We reported our experience with pergolide in the treatment of patients suffering from primary GIF and underline the fact that more research is needed on the treatment of this condition...
  50. Gil mutdinova L, Syrtlanova E, Sharapova S. [Effect of fosinopril on some parameters of endothelial function in patients with metabolic syndrome]. Kardiologiia. 2005;45:45-50 pubmed
    Angiotensin converting enzyme inhibitor fosinopril was given for 12 weeks to 92 patients with hypertension and metabolic syndrome...
  51. Mancia G, Giannattasio C, Grassi G. Treatment of heart failure with fosinopril: an angiotensin converting enzyme inhibitor with a dual and compensatory route of excretion. Am J Hypertens. 1997;10:236S-241S pubmed
    ..CHF is accompanied with a decline or some sort of effect on renal function. An ACE inhibitor with a dual route of excretion, such as fosinopril, may be especially useful in treating patients with CHF.
  52. Zhao J, Yang Y, Zhang Y, Pei W, Sun Y, Chen J, et al. Chronic pretreatment of ACEI reduces no-reflow in patients with acute myocardial infarction treated with primary angioplasty. Clin Cardiol. 2007;30:130-4 pubmed
    ..Pretreatment with ACEI could preserve the microvascular integrity after acute myocardial infarction in humans. ..
  53. Kazory A, Weiner I. Primary hyperaldosteronism in a patient with end-stage renal disease. Nephrol Dial Transplant. 2007;22:917-9 pubmed