mevinphos

Summary

Summary: An organophosphate cholinesterase inhibitor that is used as an insecticide.

Top Publications

  1. Tuovinen K, Paakkanen H, Hanninen O, Ruuskanen J. Ion mobility spectrometric monitoring of phosdrin from foliage in greenhouse. AIHAJ. 2001;62:80-6 pubmed
    The monitoring of Phosdrin (mevinphos; insecticide) from foliage and foliage extracts was achieved by an aspiration-type ion mobility spectrometer...
  2. Yen D, Chan J, Huang C, Lee C, Chan S, Chang A. Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat. Shock. 2005;23:353-9 pubmed
    ..RVLM), a medullary site where sympathetic vasomotor tone originates and where the organophosphate poison mevinphos (Mev) acts to elicit cardiovascular intoxication...
  3. Chan J, Wu C, Tsai C, Cheng H, Dai K, Chan S, et al. Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death. J Physiol. 2007;581:1293-307 pubmed
    ..Using a clinically relevant animal model that employed the organophosphate pesticide mevinphos (Mev) as the experimental insult, we evaluated the hypothesis that transcriptional up-regulation of nitric oxide ..
  4. Chan J, Chan S, Li F, Tsai C, Cheng H, Chang A. Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms. Neuropharmacology. 2005;48:161-72 pubmed
    The organophosphate insecticide mevinphos (Mev) acts on the rostral ventrolateral medulla (RVLM), where sympathetic vasomotor tone originates, to elicit phasic cardiovascular responses via nitric oxide (NO) generated by NO synthase (NOS) ..
  5. Chang A, Chan J, Kao F, Huang C, Chan S. Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat. J Biomed Sci. 2001;8:475-83 pubmed
    We evaluated the relationship between the toxicity induced by the organophosphate mevinphos (Mev) and inducible nitric oxide synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic neurogenic ..
  6. Chan J, Tsai C, Wu C, Li F, Dai K, Sun E, et al. Sumoylation of hypoxia-inducible factor-1? ameliorates failure of brain stem cardiovascular regulation in experimental brain death. PLoS ONE. 2011;6:e17375 pubmed publisher
    ..It follows that sumoylation of HIF-1? in RVLM in response to hypoxia may play a modulatory role on brain stem cardiovascular regulation during experimental brain death...
  7. Dai K, Chan S, Chang A. Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla. J Biomed Sci. 2010;17:72 pubmed publisher
    ..with an experimental model of brain stem death that employed microinjection of the organophosphate insecticide mevinphos (Mev; 10 nmol) bilaterally into RVLM of adult male Sprague-Dawley rats...
  8. Yen D, Yen J, Len W, Wang L, Lee C, Chan S. Spectral changes in systemic arterial pressure signals during acute mevinphos intoxication in the rat. Shock. 2001;15:35-41 pubmed
    We investigated the cardiovascular consequences of acute intoxication by the organophosphate poison, mevinphos (Mev), and delineated the underlying mechanism...
  9. Chan J, Cheng H, Chou J, Li F, Dai K, Chan S, et al. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. J Biol Chem. 2007;282:4585-600 pubmed
    ..the underlying mechanisms, using a clinically relevant animal model that employed the organophosphate pesticide mevinphos (Mev) as the experimental insult...

More Information

Publications41

  1. Chang C, Chang A, Chan S. Neuroprotective role of heat shock protein 70 in the rostral ventrolateral medulla during acute mevinphos intoxication in the rat. J Biomed Sci. 2004;11:748-55 pubmed
    ..origin of sympathetic neurogenic vasomotor tone in the medulla oblongata where the organophosphate insecticide mevinphos (Mev) acts to elicit cardiovascular toxicity...
  2. Li F, Tseng H, Chang A. Neuroprotective role of coenzyme Q10 against dysfunction of mitochondrial respiratory chain at rostral ventrolateral medulla during fatal mevinphos intoxication in the rat. Ann N Y Acad Sci. 2005;1042:195-202 pubmed
    ..of sympathetic vasomotor tone, in an experimental model of fatal organophosphate poisoning using the insecticide mevinphos (Mev). We also investigated the neuroprotective role of coenzyme Q10 (CoQ10) in this process...
  3. Chan J, Chan S, Chang A. Differential contributions of NOS isoforms in the rostral ventrolateral medulla to cardiovascular responses associated with mevinphos intoxication in the rat. Neuropharmacology. 2004;46:1184-94 pubmed
    The organophosphate poison mevinphos (Mev) elicits cardiovascular responses via nitric oxide (NO) produced on activation of M2 muscarinic receptors (M2R) in the rostral ventrolateral medulla (RVLM), where sympathetic vasomotor tone ..
  4. Yen D, Chan J, Tseng H, Huang C, Lee C, Chan S, et al. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Shock. 2004;21:358-63 pubmed
    ..RVLM), a medullary site where sympathetic vasomotor tone originates and where the organophosphate poison mevinphos (Mev) acts to elicit cardiovascular intoxication...
  5. Chan J, Chan S, Dai K, Cheng H, Chou J, Chang A. Cholinergic-receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos. Neuropharmacology. 2006;51:1109-19 pubmed
    ..Pheochromocytoma PC12 cells incubated with the organophosphate pesticide mevinphos (0...
  6. Chang A, Chan J, Cheng H, Tsai C, Chan S. Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death. Shock. 2009;32:651-8 pubmed publisher
    ..Based on a clinically relevant animal model that used the organophosphate pesticide mevinphos (Mev) as the experimental insult, we reported previously that heat shock protein 70 (HSP70) in RVLM plays a ..
  7. Chan S, Chan J, Hsu K, Li F, Sun E, Chen W, et al. Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death. Br J Pharmacol. 2011;164:2015-28 pubmed publisher
    ..We investigated the role of tropomyocin receptor kinase B (TrkB) and its downstream signalling pathways in the rostral ventrolateral medulla (RVLM) during experimental brain stem death...
  8. Chang C, Chang A, Chan S. De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme l1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication. Shock. 2004;22:575-81 pubmed
    ..origin of sympathetic neurogenic vasomotor tone in the medulla oblongata where the organophosphate insecticide mevinphos (Mev) acts to elicit cardiovascular toxicity...
  9. Tsai C, Wu C, Chan S, Chang A. Muscarinic receptor-independent activation of cyclic adenosine monophosphate-dependent protein kinase in rostral ventrolateral medulla underlies the sympathoexcitatory phase of cardiovascular responses during mevinphos intoxication in the rat. Shock. 2007;27:559-64 pubmed
    ..RVLM), a medullary site where sympathetic vasomotor tone originates and where the organophosphate poison mevinphos (Mev) acts, is involved in the cardiovascular responses exhibited during organophosphate intoxication...
  10. Tsai C, Chang A, Chan J, Chan S. Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication. Biochem Pharmacol. 2014;88:75-85 pubmed publisher
    ..Employing the pesticide mevinphos as our experimental tool, we evaluated the hypothesis that transcriptional upregulation of nitric oxide synthase ..
  11. Kassa J. [Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice]. Ceska Slov Farm. 1999;48:44-7 pubmed
    ..At the equi-effective level which respects the toxicity of the oxime and is therefore more important for practical use, it is a therapeutically weaker reactivator of acetylcholinesterase than HI-6. ..
  12. Kassa J, Bielavsk√Ĺ J. The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice. Pharmacol Toxicol. 1997;81:144-6 pubmed
    ..was tested in combination with atropine sulphate against acute poisoning with the organophosphorus insecticide mevinphos in mice. When mice were treated two min...
  13. Cochran R, Formoli T, Silva M, Kellner T, Lewis C, Pfeifer K. Risks from occupational and dietary exposure to mevinphos. Rev Environ Contam Toxicol. 1996;146:1-24 pubmed
    b>Mevinphos (trade name, Phosdrin), a category 1 organophosphorus insecticide, has been used mainly as a cleanup pesticide for vegetable crops...
  14. Kangas J, Laitinen S, Jauhiainen A, Savolainen K. Exposure of sprayers and plant handlers to mevinphos in Finnish greenhouses. Am Ind Hyg Assoc J. 1993;54:150-7 pubmed
    The exposure of sprayers and plant handlers to mevinphos, a toxic organophosphate insecticide, was evaluated in eight flower-growing greenhouses...
  15. Allender W, Keegan J. Chromatographic analysis of cis- and trans-mevinphos in poisoned wildlife. J Chromatogr. 1992;609:315-20 pubmed
    A method is described for the analysis of the cis- and trans-isomers of mevinphos in baits and avian tissues. The procedure involves extraction of the mevinphos isomers with acetone-dichloromethane (1:1) followed by clean-up on alumina...
  16. Kassa J. [The effect of panpal prophylaxis on acetylcholinesterase activity in the blood, diaphragm and various parts of the brain in rats during treated and untreated poisoning with the organophosphorus insecticide phosdrine]]. Ceska Slov Farm. 2000;49:37-40 pubmed
  17. Li F, Li B, Wu J, Chang A. Transition from oxidative stress to nitrosative stress in rostral ventrolateral medulla underlies fatal intoxication induced by organophosphate mevinphos. Toxicol Sci. 2013;135:202-17 pubmed publisher
    ..Using the pesticide mevinphos as our tool, we investigated the roles of oxidative stress and nitrosative stress at the rostral ventrolateral ..
  18. Blanc Lapierre A, Bouvier G, Gruber A, Leffondre K, Lebailly P, Fabrigoule C, et al. Cognitive disorders and occupational exposure to organophosphates: results from the PHYTONER study. Am J Epidemiol. 2013;177:1086-96 pubmed publisher
    ..found, but an increased risk was observed with a 50-mg increase in the cumulative score, which was greater with mevinphos (Benton Visual Retention Test: odds ratio = 3.26, 95% confidence interval: 1.54, 6...
  19. Wang A, Liu R, Liu J, Teng M, Yen M. Positron emission tomography scan in cortical visual loss in patients with organophosphate intoxication. Ophthalmology. 1999;106:1287-91 pubmed
  20. Chang A. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. J Biomed Sci. 2012;19:96 pubmed publisher
    ..An experimental model of brain stem death that employed microinjection of the organophosphate insecticide mevinphos (Mev; 10 nmol) bilaterally into RVLM of Sprague-Dawley rats was used, alongside cardiovascular, pharmacological ..
  21. Chuang C, Lin T, Tsai M. Delayed neuropathy and myelopathy after organophosphate intoxication. N Engl J Med. 2002;347:1119-21 pubmed
  22. Guan H, Brewer W, Garris S, Morgan S. Disposable pipette extraction for the analysis of pesticides in fruit and vegetables using gas chromatography/mass spectrometry. J Chromatogr A. 2010;1217:1867-74 pubmed publisher
    ..Only very polar pesticides (e.g., acephate, mathamidophos) were not extracted well using DPX-RP. ..
  23. Kassa J, Bajgar J. [Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice]. Ceska Slov Farm. 1996;45:31-4 pubmed
    ..In the therapy of intoxication 2 minutes after the exposure of experimental animals to fosdrine, the effect of the antidotal therapy was relatively low regardless of the selected oxime...
  24. Sweeden M, McLeod P. Aphicide persistence on spinach and mustard greens. J Econ Entomol. 1997;90:195-8 pubmed
    ..samples from field grown spinach and mustard greens to determine the persistence of triazamate, dimethoate, and mevinphos. Treatment with each insecticide resulted in similar mortality initially on both crops...
  25. Moser V. Age-related differences in acute neurotoxicity produced by mevinphos, monocrotophos, dicrotophos, and phosphamidon. Neurotoxicol Teratol. 2011;33:451-7 pubmed publisher
    ..compared dose-responses using brain and red blood cell (RBC) ChE measurements, along with motor activity, for mevinphos, monocrotophos, dicrotophos, and phosphamidon...
  26. Ruebhart D, Radcliffe W, Eaglesham G. Alternative bioassay for the detection of saxitoxin using the speckled cockroach (Nauphoeta cinerea). J Toxicol Environ Health A. 2011;74:621-37 pubmed publisher
    ..The N. cinerea bioassay presents a selective test for PSP toxicity that is rapid, economical, efficient, and simple to perform. ..
  27. Hsiao C, Yang C, Deng J, Bullard M, Liaw S. Acute pancreatitis following organophosphate intoxication. J Toxicol Clin Toxicol. 1996;34:343-7 pubmed
    ..No cases of acute pancreatitis following mevinphos (CAS 7786-34-71) poisoning have been reported to date...
  28. Kassa J, Vachek J. [The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice]. Cas Lek Cesk. 1997;136:124-6 pubmed
    ..Oxime HI-6 is the most effective against highly toxic organophosphates and organophosphorus insecticides when combined with the centrally acting parasympatholytic benactyzine. ..
  29. Kassa J. [Comparison of the effect of selected cholinesterase reactivators combined with atropine on soman and fosdrin toxicity in mice]. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1995;38:63-6 pubmed
    ..These findings suggest that HI-6 has definite advantage over obidoxime as well as tetroxime in the treatment of poisoning with not only highly toxic organophosphates but also organophoshorus insecticides. ..
  30. Kassa J, Bielavsk√Ĺ J. A comparison of the efficacy of new monopyridinium oximes with the oxime HI-6 against mevinphos in mice. Acta Medica (Hradec Kralove). 1999;42:9-11 pubmed
    ..HI-6 was evaluated in combination with benactyzine against acute poisoning with the organophosphorus insecticide mevinphos in mice. 2...
  31. Kassa J. [Importance of reactivation of fosdrin-inhibited acetylcholinesterase in the brain and diaphragm for the in vivo therapeutic effect of oximes in rats poisoned with fosdrin]. Cas Lek Cesk. 2000;139:237-9 pubmed
  32. Kuo W. Photocatalytic oxidation of pesticide rinsate. J Environ Sci Health B. 2002;37:65-74 pubmed
    ..Carbofuran (a carbamate pesticide) and mevinphos (an organophosphate pesticide) with a concentration of 100 mg/L were selected as the test pesticide rinsates...