coordination complexes


Summary: Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.

Top Publications

  1. Gao E, Su J, Jin H, Liu S, Zhao F, Meng Y, et al. pH Dependent synthesis of two isomeric dinuclear Cerium(II) complexes: Structures, DNA interactions, cytotoxic activity and apoptotic study. J Photochem Photobiol B. 2017;170:173-180 pubmed publisher
    ..The Cerium(II) complexes showed good cytotoxic activity against cancer cell lines, being 2 the most potent complex. Apoptotic studies of the two novel dinuclear complexes showed significant inhibitory rate on cancer cell growth line KB. ..
  2. Sarbadhikary P, Dube A. Iodinated chlorin p6 copper complex induces anti-proliferative effect in oral cancer cells through elevation of intracellular reactive oxygen species. Chem Biol Interact. 2017;277:137-144 pubmed publisher
    ..It is suggested that ICp6-Cu may provide tumor selective chemotoxicity by exploiting difference of redox environment in normal and cancer cells. ..
  3. Jones M, Dyrager C, Hoarau M, Korshavn K, Lim M, Ramamoorthy A, et al. Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-? peptide aggregation. J Inorg Biochem. 2016;158:131-138 pubmed publisher
  4. Santini C, Pellei M, Gandin V, Porchia M, Tisato F, Marzano C. Advances in copper complexes as anticancer agents. Chem Rev. 2014;114:815-62 pubmed publisher
  5. Prier C, Rankic D, MacMillan D. Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Chem Rev. 2013;113:5322-63 pubmed publisher
  6. Sato O. Switchable materials: an electric effect. Nat Chem. 2010;2:10-1 pubmed publisher
  7. Yang X, Wu T, Phipps R, Toste F. Advances in catalytic enantioselective fluorination, mono-, di-, and trifluoromethylation, and trifluoromethylthiolation reactions. Chem Rev. 2015;115:826-70 pubmed publisher
  8. Xu J, Feng C, Miao Y. Evaluation of novel 111In-labeled gonadotropin-releasing hormone peptides for human prostate cancer imaging. Bioorg Med Chem Lett. 2017;27:4647-4651 pubmed publisher
  9. Gill M, Derrat H, Smythe C, Battaglia G, Thomas J. Ruthenium(II) metallo-intercalators: DNA imaging and cytotoxicity. Chembiochem. 2011;12:877-80 pubmed publisher

More Information


  1. Gou Y, Li J, Fan B, Xu B, Zhou M, Yang F. Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents. Eur J Med Chem. 2017;134:207-217 pubmed publisher
  2. Basu A, Bhattacharjee A, Baral R, Biswas J, Samanta A, Bhattacharya S. Vanadium(III)-l-cysteine enhances the sensitivity of murine breast adenocarcinoma cells to cyclophosphamide by promoting apoptosis and blocking angiogenesis. Tumour Biol. 2017;39:1010428317705759 pubmed publisher
    ..Hence, this study suggested that vanadium(III)-l-cysteine may offer potential therapeutic benefit in combination with cyclophosphamide by augmenting anticancer efficacy and diminishing toxicity to the host. ..
  3. Sun K, Liu S, Bec P, Driver T. Rhodium-catalyzed synthesis of 2,3-disubstituted indoles from ?,?-disubstituted stryryl azides. Angew Chem Int Ed Engl. 2011;50:1702-6 pubmed publisher
  4. Zhou C, Liao T, Li Z, Gonzalez Garcia J, Reynolds M, Zou M, et al. Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes. Chemistry. 2017;23:4713-4722 pubmed publisher
    ..Based on the spectroscopic data, a possible binding mode between complex 2?c and the dimeric G-quadruplex DNA under study is proposed. ..
  5. Farrer N, Woods J, Salassa L, Zhao Y, Robinson K, Clarkson G, et al. A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angew Chem Int Ed Engl. 2010;49:8905-8 pubmed publisher
  6. Paulpandiyan R, Raman N. Oxovanadium(IV) complexes with Knoevenagel Schiff base condensate as impending chemotherapeutic agents: Synthesis, characterization, biological screening and anti-proliferative assay. Bioorg Chem. 2017;73:100-108 pubmed publisher
    ..Interestingly, complex (2) exhibits more potent cytotoxic activity than the other complex and standard drug (cisplatin). The mode of cell death was assessed by Hoechst 33258 staining morphological studies. ..
  7. Sut Lohmann M, Raab T. Quick detection and quantification of iron-cyanide complexes using fourier transform infrared spectroscopy. Environ Pollut. 2017;227:64-72 pubmed publisher
    ..Thus, FTIR spectroscopy, in combination with the statistical approach applied here seems to be a feasible and quick method for screening of contaminated sites. ..
  8. Charif R, Granotier Beckers C, Bertrand H, Poupon J, Ségal Bendirdjian E, Teulade Fichou M, et al. Association of a Platinum Complex to a G-Quadruplex Ligand Enhances Telomere Disruption. Chem Res Toxicol. 2017;30:1629-1640 pubmed publisher
  9. Mei J, Leung N, Kwok R, Lam J, Tang B. Aggregation-Induced Emission: Together We Shine, United We Soar!. Chem Rev. 2015;115:11718-940 pubmed publisher
  10. Reineke S, Rosenow T, Lüssem B, Leo K. Improved high-brightness efficiency of phosphorescent organic LEDs comprising emitter molecules with small permanent dipole moments. Adv Mater. 2010;22:3189-93 pubmed publisher
  11. Torres Martin De Rosales R, Tavare R, Paul R, Jauregui Osoro M, Protti A, Glaria A, et al. Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent. Angew Chem Int Ed Engl. 2011;50:5509-13 pubmed publisher
  12. Silva A, Luís D, Santos S, Silva J, Mendo A, Coito L, et al. Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach. Drug Metabol Drug Interact. 2013;28:167-76 pubmed publisher
  13. Oohora K, Tang N, Morita Y, Hayashi T. Cobalt tetradehydrocorrins coordinated by imidazolate-like histidine in the heme pocket of horseradish peroxidase. J Biol Inorg Chem. 2017;22:695-703 pubmed publisher
    ..Taken together, these results indicate that HRP reconstituted with cobalt tetradehydrocorrin is a suitable cobalamin-dependent enzyme model with imidazolate-like His residue. ..
  14. Vančo J, Trávníček Z, Křikavová R, Gáliková J, Dvorak Z, Chalupová M. Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents. J Photochem Photobiol B. 2017;173:423-433 pubmed publisher
  15. Zhao A, Howson S, Zhao C, Ren J, Scott P, Wang C, et al. Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA. Nucleic Acids Res. 2017;45:5026-5035 pubmed publisher
    ..Further studies show that ?1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes. ..
  16. Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H. Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance. Bioorg Med Chem. 2017;25:4686-4700 pubmed publisher
    ..Moreover, complex 10 effectively inhibited the tumor growth in the NCI-H460 xenograft model. ..
  17. Montel A, Dos Santos R, da Costa P, Silveira Lacerda E, Batista A, Dos Santos W. Neutron activation increases activity of ruthenium-based complexes and induces cell death in glioma cells independent of p53 tumor suppressor gene. Biometals. 2017;30:295-305 pubmed publisher
    ..Neutron activation of ruthenium compounds rendered them more active than their original counterparts suggesting a new strategy to improve the antitumor activity of these compounds. ..
  18. Nicolas G, Mansi R, McDougall L, Kaufmann J, Bouterfa H, Wild D, et al. Biodistribution, Pharmacokinetics, and Dosimetry of 177Lu-, 90Y-, and 111In-Labeled Somatostatin Receptor Antagonist OPS201 in Comparison to the Agonist 177Lu-DOTATATE: The Mass Effect. J Nucl Med. 2017;58:1435-1441 pubmed publisher
    ..Clinical studies are warranted to confirm the efficacy and advantageous toxicity profile of 177Lu-OPS201. ..
  19. Vellé A, Maguire R, Kavanagh K, Sanz Miguel P, Montagner D. Steroid-AuI -NHC Complexes: Synthesis and Antibacterial Activity. ChemMedChem. 2017;12:841-844 pubmed publisher
    ..Toxicity profiling was estimated in?vitro versus Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, and in?vivo on Galleria mellonella larvae against E.?coli. ..
  20. Davies H, DU BOIS J, Yu J. C-H functionalization in organic synthesis. Chem Soc Rev. 2011;40:1855-6 pubmed publisher
  21. Ross M, Fidai I, Cowan J. Analysis of Structure-Activity Relationships Based on the Hepatitis?C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK?Cu Complex. Chembiochem. 2017;18:1743-1754 pubmed publisher
    ..Together, the data yielded insights into structure-function relationships that will guide future optimization efforts. ..
  22. Sousa E Silva F, Tierno A, Wengryniuk S. Hypervalent Iodine Reagents in High Valent Transition Metal Chemistry. Molecules. 2017;22: pubmed publisher
    ..We will cover advancements in both catalysis and high valent complex isolation with a key focus on the subtle effects that oxidant choice can have on reaction outcome, as well as limitations of current reagents. ..
  23. de Barros M, Perciano P, dos Santos M, de Oliveira L, Costa E, Moreira M. Antibacterial Activity of 7-Epiclusianone and Its Novel Copper Metal Complex on Streptococcus spp. Isolated from Bovine Mastitis and Their Cytotoxicity in MAC-T Cells. Molecules. 2017;22: pubmed publisher
    ..The compounds were not cytotoxic. Based on these results, 7-epi and 7-epi-Cu exhibited desirable antimicrobial properties and could potentially be used in bovine mastitis treatment. ..
  24. Knape M, Herberg F. Metal coordination in kinases and pseudokinases. Biochem Soc Trans. 2017;45:653-663 pubmed publisher
    ..Interestingly, pseudokinases are present in all kingdoms of life and their specific roles remain enigmatic. More studies are needed to unravel the crucial functions of those interesting proteins. ..
  25. Bandyopadhyay N, Pradhan A, Das S, Naskar J. Comparative study of an osazone based ligand and its palladium(II) complex with human serum albumin: A spectroscopic, thermodynamic and molecular docking approach. J Photochem Photobiol B. 2017;173:1-11 pubmed publisher
    ..These parameters indicate that the binding processes are spontaneous both for LH2 and 1. Molecular docking analyses reveal that both LH2 and 1 reside in domain-I of HSA. ..
  26. Farrer N, Salassa L, Sadler P. Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Trans. 2009;:10690-701 pubmed publisher
    ..Nanoparticles (Ag, Au) and quantum dots (Cd) are also discussed for their photothermal destructive potential. We also discuss the potential held in particular by mixed-metal systems and Ru complexes. ..
  27. Wilk P, Uehlein M, Kalms J, Dobbek H, Mueller U, Weiss M. Substrate specificity and reaction mechanism of human prolidase. FEBS J. 2017;284:2870-2885 pubmed publisher
    ..The refined structure coordinates as well as the corresponding structure factor amplitudes have been deposited in the PDB under the accession numbers 5M4G, 5M4J, 5M4L, and 5M4Q. ..
  28. Dalm S, Haeck J, Doeswijk G, De Blois E, de Jong M, van Deurzen C. SSTR-Mediated Imaging in Breast Cancer: Is There a Role for Radiolabeled Somatostatin Receptor Antagonists?. J Nucl Med. 2017;58:1609-1614 pubmed publisher
    ..92 ± 0.43 vs. 0.90 ± 0.17; P = 0.002). Conclusion: SSTR antagonists are promising candidates for BC imaging. ..
  29. Jbara M, Guttmann Raviv N, Maity S, Ayoub N, Brik A. Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3. Bioorg Med Chem. 2017;25:4966-4970 pubmed publisher
    ..Our study enabled us to identify KDM4D lysine demethylase as a potential regulator for trimethylated H3 at Lys79. ..
  30. Xu J, Medina Rangel P, Haupt K, Tse Sum Bui B. Guide to the Preparation of Molecularly Imprinted Polymer Nanoparticles for Protein Recognition by Solid-Phase Synthesis. Methods Enzymol. 2017;590:115-141 pubmed publisher
    ..Moreover, these water-compatible polymers, targeting different domains of the enzyme, can also function as protective agents (armor), hence preventing the target proteins from denaturation by heat or pH. ..
  31. Qi J, Deng J, Qian K, Tian L, Li J, He K, et al. Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle. Eur J Med Chem. 2017;134:34-42 pubmed publisher
    ..Caspase activation was somewhat mediated by the release of Cyt C from mitochondria after incubation with selected agents. Both types of Ga(III) complexes showed more effective in inhibition of the G1/S transition than the ligand alone. ..
  32. Yamada Y. Development of Batch and Flow Immobilized Catalytic Systems with High Catalytic Activity and Reusability. Chem Pharm Bull (Tokyo). 2017;65:805-821 pubmed publisher
    ..This device promoted a variety of organic transformations as a heterogeneous catalyst. The Mizoroki-Heck reaction proceeded with 280?mol?ppb (0.000028?mol%) of the catalyst, affording the corresponding products in high yield. ..
  33. Yilmaz V, Icsel C, Batur J, Aydinlik S, Sahinturk P, Aygün M. Structures and biochemical evaluation of silver(I) 5,5-diethylbarbiturate complexes with bis(diphenylphosphino)alkanes as potential antimicrobial and anticancer agents. Eur J Med Chem. 2017;139:901-916 pubmed publisher
    ..Mechanistic studies showed that 1 and 2 display effective cell growth inhibition by triggering S and G2/M phase arrest, induce apoptosis via mitochondrial pathways and also damage to DNA due to the overproduction of ROS. ..
  34. Tesmar A, Wyrzykowski D, Kruszyński R, Niska K, Inkielewicz Stępniak I, Drzeżdżon J, et al. Characterization and cytotoxic effect of aqua-(2,2',2''-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells. Biometals. 2017;30:261-275 pubmed publisher
    ..Thus, the [VO(nta)(H2O)]- containing coordination compounds can be considered as possible antitumor agents in the osteosarcoma model of bone-related cells in culture. ..
  35. Apps M, Johnson B, Sutcliffe O, Brown S, Wheate N. Amide coupling reaction for the synthesis of bispyridine-based ligands and their complexation to platinum as dinuclear anticancer agents. J Vis Exp. 2014;: pubmed publisher
  36. Niu G, Chen X. RGD PET: From Lesion Detection to Therapy Response Monitoring. J Nucl Med. 2016;57:501-2 pubmed publisher
  37. Lapa C, Reiter T, Werner R, Ertl G, Wester H, Buck A, et al. [(68)Ga]Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction. JACC Cardiovasc Imaging. 2015;8:1466-1468 pubmed publisher
  38. Shiina I. Asymmetric Mukaiyama aldol reactions using chiral diamine-coordinated Sn(II) triflate: development and application to natural product synthesis. Chem Rec. 2014;14:144-83 pubmed
    ..In this Personal Account, the history of the development of this powerful methodology and the application of the asymmetric Mukaiyama aldol reaction in the synthesis of natural products are reviewed. ..
  39. Ringhieri P, Morelli G, Accardo A. Supramolecular Delivery Systems for Non-Platinum Metal-Based Anticancer Drugs. Crit Rev Ther Drug Carrier Syst. 2017;34:149-183 pubmed publisher
  40. Wang B, Wang Z, Ai F, Tang W, Zhu G. A monofunctional platinum(II)-based anticancer agent from a salicylanilide derivative: Synthesis, antiproliferative activity, and transcription inhibition. J Inorg Biochem. 2015;142:118-25 pubmed publisher
    ..This study not only enriches the family of monofunctional platinum-based anticancer agents but also guides the design of more potent monofunctional platinum complexes. ..
  41. Salas J, Caballero A, Esteban Parra G, Méndez Arriaga J. Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease. Curr Med Chem. 2017;24:2796-2806 pubmed publisher
  42. Hansen W, Khare S. Benchmarking a computational design method for the incorporation of metal ion-binding sites at symmetric protein interfaces. Protein Sci. 2017;26:1584-1594 pubmed publisher
  43. Rischpler C, Nekolla S, Kossmann H, Dirschinger R, Schottelius M, Hyafil F, et al. Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI. J Nucl Cardiol. 2016;23:131-3 pubmed publisher
  44. Gasser G, Ott I, Metzler Nolte N. Organometallic anticancer compounds. J Med Chem. 2011;54:3-25 pubmed publisher
  45. Popolin C, Reis J, Becceneri A, Graminha A, Almeida M, Corrêa R, et al. Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells. PLoS ONE. 2017;12:e0183275 pubmed publisher
    ..Complex (4) should be further investigated in vivo in order to stablish its potential to improve breast cancer treatment. ..
  46. Seibold U, Wängler B, Wängler C. Rational Design, Development, and Stability Assessment of a Macrocyclic Four-Hydroxamate-Bearing Bifunctional Chelating Agent for 89 Zr. ChemMedChem. 2017;12:1555-1571 pubmed publisher
    ..Finally, we performed comparative complex stability tests for 89 Zr-CHT36-c(RGDfK) and 89 Zr-DFO-c(RGDfK), showing improved complex stability for the newly developed chelator CTH36. ..
  47. Andrade Volkart P, Benedetti Gassen R, Mühlen Nogueira B, Nery Porto B, Eduardo Vargas J, Arigony Souto A. Antitumor activity of resveratrol is independent of Cu(II) complex formation in MCF-7 cell line. Bioorg Med Chem Lett. 2017;27:3238-3242 pubmed publisher
  48. Guo F, McGilvary M, Jeffries M, Graves B, Graham S, Wu Y. Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N-Boc-4-pyridone. Molecules. 2017;22: pubmed publisher
  49. Alatrash N, Narh E, Yadav A, Kim M, Janaratne T, Gabriel J, et al. Synthesis, DNA Cleavage Activity, Cytotoxicity, Acetylcholinesterase Inhibition, and Acute Murine Toxicity of Redox-Active Ruthenium(II) Polypyridyl Complexes. ChemMedChem. 2017;12:1055-1069 pubmed publisher
  50. Cardoso J, Guerreiro S, Lourenço A, Alves M, Montemor M, Mira N, et al. Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus. PLoS ONE. 2017;12:e0177355 pubmed publisher
    ..The high antibacterial and anti-Candida activities of the here studied camphorimine complexes, especially of complexes 1 and 7, suggests a potential therapeutic application for these compounds. ..
  51. Sánchez M, Sabio L, Galvez N, Capdevila M, Domínguez Vera J. Iron chemistry at the service of life. IUBMB Life. 2017;69:382-388 pubmed publisher
    ..2017 IUBMB Life, 69(6):382-388, 2017. ..
  52. Chakraborty I, Jimenez J, Sameera W, Kato M, Mascharak P. Luminescent Re(I) Carbonyl Complexes as Trackable PhotoCORMs for CO delivery to Cellular Targets. Inorg Chem. 2017;56:2863-2873 pubmed publisher
    ..These species hold significant promise as theranostic photoCORMs (photoinduced CO releasing molecules), where the entry of the pro-drug can be tracked within the cellular matrices...
  53. Mao P, Liu Y, Liu X, Wang Y, Liang J, Zhou Q, et al. Bimetallic AgCu/Cu2O hybrid for the synergetic adsorption of iodide from solution. Chemosphere. 2017;180:317-325 pubmed publisher
    ..g., acidic, alkaline and seawater environments). Therefore, this study is expected to promote the development of Cu2O into a highly efficient adsorbent for the removal of iodide from solution. ..
  54. Margheriti L, Chiappe D, Mannini M, Car P, Sainctavit P, Arrio M, et al. X-ray detected magnetic hysteresis of thermally evaporated terbium double-decker oriented films. Adv Mater. 2010;22:5488-93 pubmed publisher
  55. Warad I, Awwadi F, Daqqa M, Al Ali A, Ababneh T, AlShboul T, et al. New isomeric Cu(NO2-phen)2Br]Br complexes: Crystal structure, Hirschfeld surface, physicochemical, solvatochromism, thermal, computational and DNA-binding analysis. J Photochem Photobiol B. 2017;171:9-19 pubmed publisher
    ..Absorption and viscosity titration studies concluded that the [Cu(NO2-phen)2Br]Br complex is a very good CT-DNA binder. ..
  56. Joseph R, Rao C. Ion and molecular recognition by lower rim 1,3-di-conjugates of calix[4]arene as receptors. Chem Rev. 2011;111:4658-702 pubmed publisher
  57. Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, et al. Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate. Biosci Rep. 2013;33: pubmed publisher
  58. Bandyopadhyay N, Basu P, Kumar G, Guhathakurta B, Singh P, Naskar J. Biophysical studies on the interaction of a novel oxime based palladium(II) complex with DNA and RNA. J Photochem Photobiol B. 2017;173:560-570 pubmed publisher
    ..However, the magnitude of the binding constant as determined for RNA interaction with 1 is found to be higher than that for DNA interaction. ..
  59. Gaur R, Choubey D, Usman M, Ward B, Roy J, Mishra L. Synthesis, structures, nuclease activity, cytotoxicity, DFT and molecular docking studies of two nitrato bridged homodinuclear (Cu-Cu, Zn-Zn) complexes containing 2,2'-bipyridine and a chalcone derivative. J Photochem Photobiol B. 2017;173:650-660 pubmed publisher
    ..2±0. 044?? for complex 2. Complex 2 induces the cell apoptosis at a later-stage as compared to complex 1. The cell apoptosis and topoisomerase inhibition by complexes enable them to be potential candidates as future anticancer drugs. ..
  60. Li H, Zhou T, Liu H, Xu F, Niu Y, Wang C, et al. Discovery of a cobalt complex with high MEK1 binding affinity. Bioorg Med Chem Lett. 2017;27:2221-2224 pubmed publisher
    ..02?M) and AZD6244 (2.20?M). Docking study was used to elucidate the binding modes of complex 2 with MEK1. Thus cobalt(II) complex 2 may be further developed as a novel MEK1 inhibitor. ..
  61. Khan S, Malla A, Zafar A, Naseem I. Synthesis of novel coumarin nucleus-based DPA drug-like molecular entity: In vitro DNA/Cu(II) binding, DNA cleavage and pro-oxidant mechanism for anticancer action. PLoS ONE. 2017;12:e0181783 pubmed publisher
    ..These findings will establish ligand-L as a lead molecule to synthesize new molecules with better copper chelating and pro-oxidant properties against different malignancies. ..
  62. Nagaj J, Starosta R, Jeżowska Bojczuk M. Acid-base characterization, coordination properties towards copper(II) ions and DNA interaction studies of ribavirin, an antiviral drug. J Inorg Biochem. 2015;142:68-74 pubmed publisher
    ..It proved not to generate plasmid DNA scission products. However, the calf thymus (CT)-DNA binding studies showed that it reacts with ribavirin and its cupric complex. Moreover, the interaction with the complex is much more efficient. ..
  63. Völker T, Meggers E. Chemical Activation in Blood Serum and Human Cell Culture: Improved Ruthenium Complex for Catalytic Uncaging of Alloc-Protected Amines. Chembiochem. 2017;18:1083-1086 pubmed publisher
    ..Furthermore, alloc-protected doxorubicin, as an anticancer prodrug, could be activated in human cell culture and induced apoptosis with a single low dose (1??m) of the new catalyst. ..
  64. Jiang X, Wang R. Recent developments in catalytic asymmetric inverse-electron-demand Diels-Alder reaction. Chem Rev. 2013;113:5515-46 pubmed publisher
  65. Zhao W, Xu J, Chen H. Photoelectrochemical DNA biosensors. Chem Rev. 2014;114:7421-41 pubmed publisher
  66. M Vidal L, Pimentel E, Cruces M, Hernandez S, Ruiz Azuara L. Cytotoxic and genotoxic actions of Casiopeina III-Ea (Cas III-Ea) in somatic and germ cells of Drosophila melanogaster. J Toxicol Environ Health A. 2017;80:365-373 pubmed publisher
    ..Data suggest that Cas III-Ea is a weak genotoxic but selective mutagen. Failure to obtain a dose-related genotoxic response suggests that one of the preferred mechanisms of action of Cas III-Ea is to induce apoptosis. ..
  67. Pulido Reyes G, Martín E, Gu Coronado J, Leganés F, Rosal R, Fernández Piñas F. Physicochemical and biological interactions between cerium oxide nanoparticles and a 1,8-naphthalimide derivative. J Photochem Photobiol B. 2017;172:61-69 pubmed publisher
    ..The results of this study contribute to expand the knowledge of the interaction between nanoparticles and organic molecules which may be useful for understanding the behavior of nanoparticles in complex matrices. ..