dimethylnitrosamine

Summary

Summary: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.

Top Publications

  1. Tada S, Nakamuta M, Enjoji M, Sugimoto R, Iwamoto H, Kato M, et al. Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Exp Pharmacol Physiol. 2001;28:522-7 pubmed
    ..preventive effects of pirfenidone (PFD), an antifibrotic agent, on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. 2. Treatment with DMN caused a significant decrease in bodyweight and liver weight...
  2. Chen J, Chen H, Cheng J, Lin H, Tung Y, Lin C, et al. A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. J Ethnopharmacol. 2012;142:811-8 pubmed publisher
    ..In this study, we have investigated the affects of GZT on a rat model of dimethylnitrosamine (DMN)-induced liver fibrosis...
  3. Suzuki K, Aoki K, Ohnami S, Yoshida K, Kazui T, Kato N, et al. Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model. Gene Ther. 2003;10:765-73 pubmed
    ..adenovirus vector expressing the rat IFN-alpha gene (AxCA-rIFN) was injected intravenously into rats with dimethylnitrosamine-induced LC...
  4. Chong L, Hsu Y, Chiu Y, Yang K, Huang Y. Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. J Biomed Sci. 2006;13:403-18 pubmed
    ..An in vivo therapeutic study was conducted in dimethylnitrosamine (DMN)-treated rats, which were randomly assigned to 1 of 4 groups: vehicle (0...
  5. Yen M, Weng T, Liu S, Chai C, Lin C. The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats. Biol Pharm Bull. 2005;28:442-8 pubmed
    ..kaoi, an endemic plant to Taiwan, were used to be examined the hepatoprotective effect against dimethylnitrosamine (DMN)-induced hepatic fibrosis in rats, they were water extract (BKW), polysaccharide-enriched fractions (..
  6. Morinaga A, Ogata T, Kage M, Kinoshita H, Aoyagi S. Comparison of liver regeneration after a splenectomy and splenic artery ligation in a dimethylnitrosamine-induced cirrhotic rat model. HPB (Oxford). 2010;12:22-30 pubmed publisher
    ..However, there are no studies that directly compared the effects of a splenectomy and splenic artery ligation. In the present study, we compared the effects of a splenectomy and splenic artery ligation in cirrhotic rats...
  7. Lee M, Yoon S, Moon J. The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats. Biol Pharm Bull. 2004;27:72-6 pubmed
    ..In this study, we investigated the protective effect of naringenin on hepatic injury induced by dimethylnitrosamine (DMN) in rats...
  8. Galli A, Crabb D, Ceni E, Salzano R, Mello T, Svegliati Baroni G, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 2002;122:1924-40 pubmed
    ..or rosiglitazone) was tested on liver fibrosis induced in rats by either toxin administration (dimethylnitrosamine or carbon tetrachloride) or bile duct ligation...
  9. Kim E, Kim J, Choi M, Hong S, Bae Y. Effects of excretory/secretory products from Clonorchis sinensis and the carcinogen dimethylnitrosamine on the proliferation and cell cycle modulation of human epithelial HEK293T cells. Korean J Parasitol. 2008;46:127-32 pubmed publisher
    ..In cells exposed to the excretory/secretory products (ESP) of C. sinensis and the carcinogen dimethylnitrosamine (DMN), cellular proliferation and the proportion of cells in the G2/M phase increased...

More Information

Publications62

  1. Nakamuta M, Ohta S, Tada S, Tsuruta S, Sugimoto R, Kotoh K, et al. Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Int J Mol Med. 2001;8:553-60 pubmed
    We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight...
  2. Tanaka H, Ueda H, Fukuchi H, Ichinose M. Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine. Clin Exp Med. 2009;9:229-33 pubmed publisher
    ..Therefore, we examined its effect of EDA in rat model of liver cirrhosis induced by dimethylnitrosamine (DMN)...
  3. George J. Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Chim Acta. 2003;335:39-47 pubmed
    ..Liver injury was induced by intraperitoneal injections of dimethylnitrosamine (DMN) on three consecutive days of every week over a period of 21 days...
  4. Nishibe Y, Kaneko H, Suzuki H, Abe T, Matsuura Y, Takaku H. Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model. Gene Ther. 2008;15:990-7 pubmed publisher
    ..investigated the in vivo effect of AcMNPV in the mouse model of liver cirrhosis induced by the mutagen dimethylnitrosamine. Intraperitoneal injection of AcMNPV induced an immune response...
  5. Tahan V, Ozaras R, Canbakan B, Uzun H, Aydin S, Yildirim B, et al. Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats. J Pineal Res. 2004;37:78-84 pubmed
    ..We aimed to test the effects of melatonin on dimethylnitrosamine (DMN)-induced liver damage in rats. Wistar albino rats were injected with DMN intraperitoneally...
  6. Sathish P, Paramasivan V, Palani V, Sivanesan K. N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol. 2011;654:181-6 pubmed publisher
    ..was aimed to investigate the hepatoprotective and antioxidant property of N-acetylcysteine (NAC) against dimethylnitrosamine (DMN) induced oxidative stress and hepatocellular damage in male Wistar albino rats...
  7. Lee E, Lee H, Shin J, Yoon S, Moon J. The flavonoid quercetin inhibits dimethylnitrosamine-induced liver damage in rats. J Pharm Pharmacol. 2003;55:1169-74 pubmed
    ..In this study, we investigated the protective effect of quercetin on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight...
  8. Lee M, Liu M, Cheng A, Tsai M, Ho C, Liou W, et al. Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. Food Chem. 2013;138:802-7 pubmed publisher
    ..These data demonstrated that pterostilbene exhibited hepatoprotective effects on experimental fibrosis, potentially by inhibiting the TGF-?1/Smad signaling. ..
  9. Kma L, Sharan R. In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins. Mol Cell Biochem. 2006;288:143-9 pubmed
    ..PAR of bone marrow cell (BMC) and blood lymphocyte (BL) proteins in mice chronically exposed to low dose of dimethylnitrosamine (DMN) for up to four weeks in vivo...
  10. George J. Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis. Clin Biochem. 2006;39:984-91 pubmed
    ..The liver injury was induced by intraperitoneal injections of dimethylnitrosamine (DMN; N-nitrosodimethylamine, NDMA) in doses 1 mg/100 g body weight on 3 consecutive days of each week over ..
  11. Su L, Hsu S, Yang J, Tseng H, Huang S, Huang C. Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis. Gene Expr. 2006;13:107-32 pubmed
    ..Here we used dimethylnitrosamine (DMN), a nongenotoxic hepatotoxin, to induce rat necroinflammatory and hepatic fibrosis...
  12. Latella G, Vetuschi A, Sferra R, Catitti V, D Angelo A, Zanninelli G, et al. Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int. 2009;29:997-1009 pubmed publisher
    ..evaluate the potential protective role of Smad3 deficiency in the pathogenesis of liver fibrosis induced by dimethylnitrosamine (DMN) in Smad3 null mice...
  13. Lim C, Kim E, Lee H, Soh Y, Sohn Y, Kim S, et al. Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats. Biosci Biotechnol Biochem. 2010;74:477-83 pubmed
    ..In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN)...
  14. Choi J, Hwang Y, Choi C, Chung Y, Jeong H. Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats. Food Chem Toxicol. 2010;48:3137-43 pubmed publisher
    ..the anthocyanin fraction (AF) obtained from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine (DMN) administration in rats...
  15. Teng Y, Sun C, Li G, Sun G, Nomachi Y, Yokota J, et al. Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats. J Nat Med. 2010;64:288-94 pubmed publisher
    ..effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg dimethylnitrosamine (DMN)...
  16. Bae S, Lee S, Lee J, Lee Y, Lee I, Kim S, et al. Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. Int J Pharm. 2004;275:227-38 pubmed
    ..at a dose of 30 mg/kg to control Sprague-Dawley rats and rats with liver cirrhosis induced by dimethylnitrosamine. After intravenous administration in rats with liver cirrhosis, the area under the plasma concentration-..
  17. de Gouville A, Boullay V, Krysa G, Pilot J, Brusq J, Loriolle F, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005;145:166-77 pubmed
    ..in TGF-beta-overexpressing transgenic mice, in an acute model of liver disease and in a chronic model of dimethylnitrosamine (DMN)-induced liver fibrosis...
  18. Devi B, Schneeweiss F, Sharan R. Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: a possible biomarker for cancer detection. Cancer Detect Prev. 2005;29:66-71 pubmed
    ..Swiss albino mice were exposed to hepatocarcinogen, dimethylnitrosamine (DMN), at a chronic dose, which is known to induce carcinogenesis in liver...
  19. Kusunose M, Qiu B, Cui T, Hamada A, Yoshioka S, Ono M, et al. Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats. Biol Pharm Bull. 2002;25:1417-21 pubmed
    ..The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats...
  20. Hwang Y, Choi J, Yun H, Han E, Kim H, Kim J, et al. Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Food Chem Toxicol. 2011;49:93-9 pubmed publisher
    ..We examined whether an anthocyanin fraction (AF) from purple sweet potato may prevent dimethylnitrosamine (DMN)-induced liver injury by inducing antioxidants via nuclear erythroid 2-related factor 2 (Nrf2) ..
  21. Ray S, Parikh H, Bagchi D. Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Mutat Res. 2005;579:81-106 pubmed
    ..and co-exposure of proanthocyanidin-rich grape seed extract (GSPE) in preventing, reducing and/or delaying dimethylnitrosamine (N-nitrosodimethylamine, DMN)-induced liver tumorigenesis, carcinogenesis and mortality in male B6C3F1 mice ..
  22. Lu X, Liu P, Liu C, Xu G, Wang X, Chen W, et al. [Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats]. Zhonghua Gan Zang Bing Za Zhi. 2002;10:441-4 pubmed
    To study the role of hepatic sinusoidal endothelium injury during hepatic fibrogenesis induced by dimethylnitrosamine (DMN) in rats...
  23. Hamada T, Sato A, Hirano T, Yamamoto T, Son G, Onodera M, et al. Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats. Am J Pathol. 2007;171:872-81 pubmed
    ..we examined whether the introduction of OSM cDNA enhances the regeneration of livers damaged by dimethylnitrosamine (DMN) in rats...
  24. Wang X, Hu Y, Liu C, Liu P, Zhu D. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis]. Zhong Xi Yi Jie He Xue Bao. 2005;3:286-9 pubmed
    ..Rats in the untreated and SA-B-treated groups were injected intraperitoneally with 0.5% dimethylnitrosamine (DMN) for 4 weeks, daily for 3 days each week at a dose of 10 microg/kg, to induce hepatic fibrosis...
  25. Hong S, Jung K, Zheng H, Lee H, Suh J, Park I, et al. The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats. Arch Pharm Res. 2010;33:601-9 pubmed publisher
    ..In this study, we investigated the protective effects of resveratrol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats...
  26. Li W, Chen C, Xu M, Guo J, Li Y, Xia Q, et al. The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J. 2011;278:1522-32 pubmed publisher
    ..Here, we sought to examine whether microRNA (miRNA) became dysregulated in dimethylnitrosamine-induced hepatic fibrosis in rats...
  27. Takahara Y, Takahashi M, Wagatsuma H, Yokoya F, Zhang Q, Yamaguchi M, et al. Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. World J Gastroenterol. 2006;12:6473-99 pubmed
    ..Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis. ..
  28. Farombi E, Shrotriya S, Na H, Kim S, Surh Y. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol. 2008;46:1279-87 pubmed
    ..that oral administration of curcumin at 200mg/kg dose for four consecutive days not only protected against dimethylnitrosamine (DMN)-induced hepatic injury, but also resulted in more than three-fold induction of HO-1 protein ..
  29. Narmada B, Kang Y, Venkatraman L, Peng Q, Sakban R, Nugraha B, et al. Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis. Hum Gene Ther. 2013;24:508-19 pubmed publisher
    ..In rats, dimethylnitrosamine-induced liver fibrosis is manifested by an increase in collagen deposition and severe defenestration of ..
  30. Tada S, Iwamoto H, Nakamuta M, Sugimoto R, Enjoji M, Nakashima Y, et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol. 2001;34:529-36 pubmed
    ..that an inhibitor specific for p160ROCK (Y27632) could prevent experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Y27632 was given orally at 30 mg/kg daily for 4 weeks after the first injection of DMN...
  31. Lu X, Liu P, Xu G, Liu C, Li F, Liu C. [The role of hepatic sinusoid capillarization during the formation of portal hypertension in fibrotic rats induced by dimethylnitrosamine]. Zhonghua Gan Zang Bing Za Zhi. 2003;11:595-8 pubmed
    ..of hepatic sinusoid capillarization during the formation of portal hypertension in fibrotic rats induced by dimethylnitrosamine (DMN)...
  32. Kitamura K, Nakamoto Y, Akiyama M, Fujii C, Kondo T, Kobayashi K, et al. Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis. Lab Invest. 2002;82:571-83 pubmed
    ..the pathophysiologic role of the TNF-alpha/TNF receptor (TNFR) p55 signals in liver fibrosis, 10 mg/kg of dimethylnitrosamine, a specific hepatotoxicant, was administered twice a week into the peritoneal cavity of both TNFRp55 knock-..
  33. Lin H, Chen J, Lin C, Kao S, Cheng J, Chen H, et al. Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis. J Ethnopharmacol. 2011;134:953-60 pubmed publisher
    ..The present investigation was designed to assess the involvement of the fibrosis pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Liver fibrosis was induced by DMN injection (10mg/kg, i.p...
  34. Liu C, Tao Q, Sun M, Wu J, Yang W, Jian P, et al. Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab Invest. 2010;90:1805-16 pubmed publisher
    ..Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment...
  35. Lee E, Shin M, Yoon S, Moon J. Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Arch Pharm Res. 2010;33:925-32 pubmed publisher
    ..In this study, we investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats...
  36. Jung K, Hong S, Zheng H, Lee D, Hong S. Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J Pineal Res. 2009;47:173-83 pubmed publisher
    ..The study aimed to determine whether melatonin could prevent dimethylnitrosamine (DMN)-induced liver injury through nuclear erythroid 2-related factor 2 (Nrf2) and inflammation...
  37. Vendemiale G, Grattagliano I, Caruso M, Serviddio G, Valentini A, Pirrelli M, et al. Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha. Toxicol Appl Pharmacol. 2001;175:130-9 pubmed
    ..This study evaluated (1) the effect of the profibrotic agent dimethylnitrosamine (DMN) on the hepatic oxidative balance in the rat; (2) the role played by the antioxidant agent N-..
  38. Akamatsu S, Watanabe A, Tamesada M, Nakamura R, Hayashi S, Kodama D, et al. Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biol Pharm Bull. 2004;27:1957-60 pubmed
    ..The L.E.M. and ESMe were then examined for their hepatoprotective effect on dimethylnitrosamine-injured mice...
  39. Jabłoński J, Jabłońska E, Moniuszko Jakoniuk J. The Effect of N-nitrosodimethylamine on TRAIL and DR5 expression in human neutrophils--preliminary study. Immunopharmacol Immunotoxicol. 2007;29:287-96 pubmed
    ..However, the expression and secretion of DR5 by PBMCs were similar to those by PMNs. Differences above suggest that PMNs are more sensitive to unfavorable action of NDMA than PBMCs. ..
  40. Fong L, Nguyen V, Farber J. Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J Natl Cancer Inst. 2001;93:1525-33 pubmed
    ..Zinc replenishment of NMBA-treated ZD rats rapidly induces apoptosis in esophageal epithelial cells and thereby substantially reduces the development of esophageal cancer. ..
  41. Zhao X, Wang B, Wang T, Li X. [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2006;86:2563-6 pubmed
    ..into three groups: control group (15 rats); DMN model group (23 rats), injected intraperitoneally with dimethylnitrosamine (DMN) 10 mg/kg twice per week for 8 weeks to induce hepatic fibrosis; and silymarin group (23 rats), ..
  42. Hobbie K, DeAngelo A, George M, Law J. Neoplastic and nonneoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish. Vet Pathol. 2012;49:372-85 pubmed publisher
    ..b>Dimethylnitrosamine, used in rats to model human alcoholic cirrhosis and hepatic neoplasia, is also a potent hepatotoxin and ..
  43. Hsu Y, Lin Y, Chiu Y, Shiao M, Lee C, Huang Y. Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats. J Biomed Sci. 2005;12:185-95 pubmed
    ..Fibrosis was induced by dimethylnitrosamine (DMN) administration in rats...
  44. Sagelsdorff P, Lutz W, Schlatter C. DNA methylation in rat liver by daminozide, 1,1-dimethylhydrazine, and dimethylnitrosamine. Fundam Appl Toxicol. 1988;11:723-30 pubmed
    ..succinic acid 2',2'-dimethylhydrazide; 37 mg/kg), 1,1-[14C]dimethylhydrazine (UDMH; 19 mg/kg), and [14C]dimethylnitrosamine (DMNA; 0.1 mg/kg) were administered by oral gavage to male Sprague-Dawley rats...
  45. Mwanza T, Miyamoto T, Okumura M, Kadosawa T, Fujinaga T. Ultrasonography, biochemical and hematological profiles in liver disease caused by intravenous administration of dimethylnitrosamine in dogs. Jpn J Vet Res. 1997;45:153-61 pubmed
    ..function tests and ultrasonographical findings were analysed in 7 dogs that were intravenously injected dimethylnitrosamine (DMNA 2 mg/kg body weight) on 2 consecutive days each week for 10 weeks...
  46. Butterworth B, Templin M, Constan A, Sprankle C, Wong B, Pluta L, et al. Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice. Environ Mol Mutagen. 1998;31:248-56 pubmed
    ..The positive control, dimethylnitrosamine (DMN) is a DNA-reactive mutagen and carcinogen...
  47. Hutton J, Meier J, Hackney C. Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls. Mutat Res. 1979;66:75-94 pubmed
    ..and colon from 8 strains of mice were compared for their ability to metabolize benzo[a]pyrene (BP) and dimethylnitrosamine (DMN) to mutagens...
  48. Asakura S, Daimon H, Sawada S, Sagami F. A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea. Toxicol Lett. 1998;98:155-67 pubmed
    ..effects were studied in the hepatocytes of F344 rats exposed in vivo to the methylating agents dimethylnitrosamine (DMN, hepatocarcinogen) and methylnitrosourea (MNU, non-hepatocarcinogen)...
  49. George J, Chandrakasan G. Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine. Clin Biochem. 2000;33:563-70 pubmed
    ..The liver injury was induced in adult male albino rats by using dimethylnitrosamine (DMN) in doses of 1 mg/100 g body weight...
  50. George J, Rao K, Stern R, Chandrakasan G. Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology. 2001;156:129-38 pubmed
    b>Dimethylnitrosamine (DMN) is a potent hepatotoxin that can cause fibrosis of the liver. It's ability to provide a suitable rapid experimental murine model for early human cirrhosis was examined...
  51. Gollapudi B, Jackson K, Stott W. Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine. Mutat Res. 1998;419:131-5 pubmed
    ..of the Big Blue(R) rat for the detection of in vivo mutations was investigated by studying spontaneous and dimethylnitrosamine (DMN)-induced hepatic mutations...
  52. Yasuda M, Shimizu I, Shiba M, Ito S. Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. Hepatology. 1999;29:719-27 pubmed
    ..estradiol, hepatic fibrosis was induced in male and female rats by the administration of a single dose of dimethylnitrosamine (DMN)...
  53. Shane B, Smith Dunn D, de Boer J, Glickman B, Cunningham M. Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice. Mutat Res. 2000;452:197-210 pubmed
    ..mutational spectrum (MS) of lacI and cII from the same DNA samples isolated from the liver of control and dimethylnitrosamine (DMN)-treated mice. A three-fold (p<0...