furazolidone

Summary

Summary: A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)

Top Publications

  1. Isakov V, Domareva I, Koudryavtseva L, Maev I, Ganskaya Z. Furazolidone-based triple 'rescue therapy' vs. quadruple 'rescue therapy' for the eradication of Helicobacter pylori resistant to metronidazole. Aliment Pharmacol Ther. 2002;16:1277-82 pubmed
    ..To compare the efficacy of quadruple and furazolidone-based triple therapy in the eradication of H. pylori resistant to metronidazole...
  2. Guo C, Wu Y, Liu H, Wu J, Zhong M. Clinical evaluation of four one-week triple therapy regimens in eradicating Helicobacter pylori infection. World J Gastroenterol. 2004;10:747-9 pubmed
    ..treatment with OAC (omeprazole 20 mg + amoxicillin 1 000 mg + clarithromycin 250 mg), OFC (omeprazole 20 mg + furazolidone 100 mg + clarithromycin 250 mg), OFA (omeprazole 20 mg + furazolidone 100 mg + amoxicillin 1 000 mg) and OMC (..
  3. Abbas Z, Yakoob J, Abid S, Jafri W, Islam M, Azam Z, et al. Furazolidone, co-amoxiclav, colloidal bismuth subcitrate, and esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy. Dig Dis Sci. 2009;54:1953-7 pubmed publisher
    ..UBT) done 4-6 weeks after the completion of triple therapy were offered a combination regimen comprised of furazolidone 200 mg b.i.d, co-amoxiclav 1 g b.i.d., colloidal bismuth subcitrate 240 mg b.i.d., and esomeprazole 40 mg b.i.d...
  4. Treiber G, Ammon S, Malfertheiner P, Klotz U. Impact of furazolidone-based quadruple therapy for eradication of Helicobacter pylori after previous treatment failures. Helicobacter. 2002;7:225-31 pubmed
    ..This study investigated whether a quadruple regimen containing furazolidone could be effective as a third-line (salvage) therapy. All patients with previous H...
  5. Frota L, da Cunha M, Luz C, de Araujo Filho A, Frota L, Braga L. Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy: an open randomized clinical trial. Arq Gastroenterol. 2005;42:111-5 pubmed
    ..To evaluate H. pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy in northeastern of Brazil...
  6. Jin X, Tang S, Chen Q, Zou J, Zhang T, Liu F, et al. Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells. Toxicol Lett. 2011;201:205-12 pubmed publisher
    b>Furazolidone (FZD) is an antimicrobial agent that has been shown to have mutagenic, genotoxic and potentially carcinogenic properties when tested in a variety of systems in vitro and in vivo...
  7. Coelho L, Moretzsohn L, Vieira W, Gallo M, Passos M, Cindr J, et al. New once-daily, highly effective rescue triple therapy after multiple Helicobacter pylori treatment failures: a pilot study. Aliment Pharmacol Ther. 2005;21:783-7 pubmed
    ..To determine the efficacy of the combination of rabeprazole, levofloxacin and furazolidone as a rescue therapy. Duodenal ulcer patients previously submitted, without success, to at least two H...
  8. Wong W, Wong B, Lu H, Gu Q, Yin Y, Wang W, et al. One-week omeprazole, furazolidone and amoxicillin rescue therapy after failure of Helicobacter pylori eradication with standard triple therapies. Aliment Pharmacol Ther. 2002;16:793-8 pubmed
    To test the efficacy of omeprazole, furazolidone and amoxicillin triple therapy for the treatment of Helicobacter pylori infection after failure of standard first-line therapy recommended by the Asia-Pacific Consensus on the management of ..
  9. Huo X, Chu J, Yang X, Wang J, Zhang L, Ma J, et al. Efficacy of one-day quadruple therapy for H pylori infection in Chinese patients. World J Gastroenterol. 2006;12:3105-7 pubmed
    ..and confirmed H pylori infection were randomized to receive either omeprazole 40 mg, amoxycillin 1 g, and furazolidone 100 mg, all twice a day for 7 d or omeprazole 20 mg (at breakfast and dinner), amoxicillin 1 g, furazolidone ..

More Information

Publications62

  1. Fakheri H, Malekzadeh R, Merat S, Khatibian M, Fazel A, Alizadeh B, et al. Clarithromycin vs. furazolidone in quadruple therapy regimens for the treatment of Helicobacter pylori in a population with a high metronidazole resistance rate. Aliment Pharmacol Ther. 2001;15:411-6 pubmed
    ..Both clarithromycin and furazolidone are potential alternatives for metronidazole...
  2. Felga G, Silva F, Barbuti R, Navarro Rodriguez T, Zaterka S, Eisig J. Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease. World J Gastroenterol. 2008;14:6224-7 pubmed
    To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole, bismuth subcitrate, furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens ..
  3. Xiao S, Liu W, Hu P, Xia D, Tytgat G. High cure rate of Helicobacter pylori infection using tripotassium dicitrato bismuthate, furazolidone and clarithromycin triple therapy for 1 week. Aliment Pharmacol Ther. 1999;13:311-5 pubmed
    ..d. and two antibiotics: furazolidone 100 mg b.d. plus clarithromycin 250 mg b.d. (Group A); or clarithromycin 250 mg b.d. plus amoxycillin 1000 mg b...
  4. Reimão J, Taniwaki N, Tempone A. Furazolidone is a selective in vitro candidate against Leishmania (L.) chagasi: an ultrastructural study. Parasitol Res. 2010;106:1465-9 pubmed publisher
    ..parasites including the use of re-purposed drugs. Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity and is used for the treatment of ..
  5. Fu H, Leng W, Wang J, Zhang W, Peng J, Wang L, et al. Transcriptional profile induced by furazolidone treatment of Shigella flexneri. Appl Microbiol Biotechnol. 2007;77:657-67 pubmed
    ..b>Furazolidone, a nitrofuran derivative, is very effective against the infection with S. flexneri...
  6. Buzás G, Józan J. Nitrofuran-based regimens for the eradication of Helicobacter pylori infection. J Gastroenterol Hepatol. 2007;22:1571-81 pubmed
    ..The aim of this study was the systematic review and meta-analysis of the effect of furazolidone- and nitrofurantoin-based regimens in the eradication of infection...
  7. Liu W, Xiao S, Hu P, Lu H, Cui Y, Tytgat G. A new quadruple therapy for Helicobacter pylori using tripotassium dicitrato bismuthate, furazolidone, josamycin and famotidine. Aliment Pharmacol Ther. 2000;14:1519-22 pubmed
    In our previous study, a triple therapy using tripotassium dicitrato bismuthate (TDB), josamycin and furazolidone achieved a suboptimal cure rate of Helicobacter pylori infection...
  8. Calafatti S, Ortiz R, Deguer M, Martinez M, Pedrazzoli J. Effect of acid secretion blockade by omeprazole on the relative bioavailability of orally administered furazolidone in healthy volunteers. Br J Clin Pharmacol. 2001;52:205-9 pubmed
    ..of this study was to investigate the effects of a 5 day administration of omeprazole on the pharmacokinetics of furazolidone. Eighteen healthy (nine male and nine female) volunteers were selected...
  9. Nijevitch A, Shcherbakov P, Sataev V, Khasanov R, Al Khashash R, Tuygunov M. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy with nifuratel to furazolidone. Aliment Pharmacol Ther. 2005;22:881-7 pubmed
    ..To evaluate the efficacy of amoxicillin, bismuth subcitrate and omeprazole and nifuratel or furazolidone for H. pylori eradication in children who failed initial treatment with a standard triple therapy...
  10. Khatibian M, Ajvadi Y, Nasseri Moghaddam S, Ebrahimi Dariani N, Vahedi H, Zendehdel N, et al. Furazolidone-based, metronidazole-based, or a combination regimen for eradication of Helicobacter pylori in peptic ulcer disease. Arch Iran Med. 2007;10:161-7 pubmed
    b>Furazolidone has been effective against Helicobacter pylori in Iran, with no resistance, but with intolerable side effects in the second week. One-week regimens have not been useful here...
  11. De Francesco V, Ierardi E, Hassan C, Zullo A. Furazolidone therapy for Helicobacter pylori: is it effective and safe?. World J Gastroenterol. 2009;15:1914-5 pubmed
    Some aspects related with the use of furazolidone as a rescue therapy for Helicobacter pylori (H pylori) infection should be remarked, especially regarding its potential oncologic risk...
  12. Hausen M, Freitas J, Monteiro Leal L. The effects of metronidazole and furazolidone during Giardia differentiation into cysts. Exp Parasitol. 2006;113:135-41 pubmed
    ..Supported by this knowledge, we analyzed the inhibitory effects of metronidazole (MZ) and furazolidone (FZ) on the differentiation of Giardia into cysts and its viability...
  13. Neal R, Van Bueren J, Hooper G. The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo. Ann Trop Med Parasitol. 1988;82:453-6 pubmed
    b>Furazolidone and nitrofurazone showed in vitro activity against amastigotes of Leishmania donovani, L. enriettii and L. major in macrophages, at concentrations which were also toxic to the macrophages...
  14. Tempone A, Mortara R, de Andrade H, Reimão J. Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis. Int J Antimicrob Agents. 2010;36:159-63 pubmed publisher
    ..In this study, we developed a liposomal formulation of furazolidone that targets Leishmania (Leishmania) chagasi amastigotes in a hamster model...
  15. Eisig J, Silva F, Rodriguez T, Hashimoto C, Barbuti R. A furazolidone-based quadruple therapy for Helicobacter pylori retreatment in patients with peptic ulcer disease. Clinics (Sao Paulo). 2005;60:485-8 pubmed
    ..This study was aimed at assessing the efficacy and safety of a quadruple therapy with furazolidone for H. pylori retreatment. Patients who had failed one or more eradication regimens against H...
  16. Kawakami E, Machado R, Ogata S, Langner M, Fukushima E, Carelli A, et al. Furazolidone-based triple therapy for H pylori gastritis in children. World J Gastroenterol. 2006;12:5544-9 pubmed
    To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis. A prospective and consecutive open trial was carried out...
  17. Verdon E, Couedor P, Sanders P. Multi-residue monitoring for the simultaneous determination of five nitrofurans (furazolidone, furaltadone, nitrofurazone, nitrofurantoine, nifursol) in poultry muscle tissue through the detection of their five major metabolites (AOZ, AMOZ, SEM, AHD,. Anal Chim Acta. 2007;586:336-47 pubmed
    Following the ban of four nitrofurans in the mid-90s (furazolidone, furaltadone, nitrofurantoine, nitrofurazone), the nifursol, a veterinary drug from the nitrofuran class of antibacterials which has been used prophylactically as feed ..
  18. Araujo Castillo R, Pinto Valdivia J, Ramírez D, Cok Garcia J, Bussalleu Rivera A. [New ultrashort scheme for helicobacter pylori infection eradication using tetracyline, furazolidone and colloidal bismuth subcitrate in dyspeptic patients with or without peptic ulceration in the National Hospital Cayetano Heredia]. Rev Gastroenterol Peru. 2005;25:23-41 pubmed
    ..They were randomly assigned to receive one of the following therapeutic schemes: tetracycline 500 mg qid, furazolidone 100 mg qid and colloidal bismuth subcitrate 120 mg qid for 3 days (Scheme I) or 4 days (Scheme II)...
  19. Riahizadeh S, Malekzadeh R, Agah S, Zendehdel N, Sotoudehmanesh R, Ebrahimi Dariani N, et al. Sequential metronidazole-furazolidone or clarithromycin-furazolidone compared to clarithromycin-based quadruple regimens for the eradication of Helicobacter pylori in peptic ulcer disease: a double-blind randomized controlled trial. Helicobacter. 2010;15:497-504 pubmed publisher
    b>Furazolidone is a much cheaper drug with a very low resistance against Helicobacter pylori compared to clarithromycin...
  20. Graham D, Osato M, Hoffman J, Opekun A, Anderson S, El Zimaity H. Furazolidone combination therapies for Helicobacter pylori infection in the United States. Aliment Pharmacol Ther. 2000;14:211-5 pubmed
    Antibiotic resistance has begun to impair the ability to cure Helicobacter pylori infection. To evaluate furazolidone as a component of combination therapies for treatment of H. pylori infection in the United States...
  21. Xiao S, Liu W, Hu P, Ouyang Q, Wang J, Zhou L, et al. A multicentre study on eradication of Helicobacter pylori using four 1-week triple therapies in China. Aliment Pharmacol Ther. 2001;15:81-6 pubmed
    ..pylori of 1-week regimens containing three medications: omeprazole (O) or colloidal bismuth subcitrate (B), furazolidone (F) or metronidazole (M), and amoxicillin (A) or clarithromycin (C)...
  22. Qasim A, Sebastian S, Thornton O, Dobson M, McLoughlin R, Buckley M, et al. Rifabutin- and furazolidone-based Helicobacter pylori eradication therapies after failure of standard first- and second-line eradication attempts in dyspepsia patients. Aliment Pharmacol Ther. 2005;21:91-6 pubmed
    ..care level was treated using strategies including antibiotic sensitivity testing and the use of rifabutin- and furazolidone-based therapies...
  23. Ebrahimi Dariani N, Mirmomen S, Mansour Ghanaei F, Noormohammadpoor P, Sotodehmanesh R, Haghpanah B, et al. The efficacy of furazolidone-based quadruple therapy for eradication of Helicobacter pylori infection in Iranian patients resistant to metronidazole-based quadruple therapy. Med Sci Monit. 2003;9:PI105-8 pubmed
    b>Furazolidone has recently shown promising efficacy in H...
  24. Roghani H, Massarrat S, Shirekhoda M, Butorab Z. Effect of different doses of furazolidone with amoxicillin and omeprazole on eradication of Helicobacter pylori. J Gastroenterol Hepatol. 2003;18:778-82 pubmed
    ..In contrast, the clarithromycin-based regimen is not cost-effective for developing countries. Furazolidone is a very good substitute for metronidazole and clarithromycin, but its many side-effects limit widespread use...
  25. Bartlet A, Harvey S, Klandorf H. Contrasting effects of nitrofurans on plasma corticosterone in chickens following administration as a bolus or diet additive. J Vet Pharmacol Ther. 1990;13:261-9 pubmed
    Administration of furazolidone as a bolus dose (8-500 mg/kg), produced a decrease in plasma corticosterone in chickens. In contrast, addition of furazolidone or furaltadone to the diet (0...
  26. Sotoudehmanesh R, Malekzadeh R, Vahedi H, Dariani N, Asgari A, Massarrat S. Second-line Helicobacter pylori eradication with a furazolidone-based regimen in patients who have failed a metronidazole-based regimen. Digestion. 2001;64:222-5 pubmed
    ..In a retrospective study, we undertook to evaluate efficacy and tolerability of a furazolidone-based regimen (omeprazole, furazolidone, bismuth, and tetracycline) in patients who had previously failed the ..
  27. Su Z, Xu H, Zhang C, Shao S, Li L, Wang H, et al. Mutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistance. Croat Med J. 2006;47:410-5 pubmed
    To determine the rate of furazolidone resistance of Helicobacter pylori (H. pylori) isolated from gastric biopsy specimens and to explore the relationship between genetic mutations in porD and oorD genes of H...
  28. Prasad C, Sripriya V, Saha R, Parimoo P. Simultaneous determination of tinidazole, furazolidone and diloxanide furoate in a combined tablet preparation by second-derivative spectrophotometry. J Pharm Biomed Anal. 1999;21:961-8 pubmed
    ..spectrophotometric procedure has been developed for the simultaneous determination of tinidazole (TD), furazolidone (FD) and diloxanide furoate (DF) in a commercial preparation...
  29. Sasaki N, Sakai N, Ikenaka Y, Kamiya T, Heewon M, Sakamoto K, et al. Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liver. J Vet Med Sci. 2008;70:223-6 pubmed
    b>Furazolidone (FZ), one of the nitrofuran fungicides, is used as a veterinary medicine in the Middle and Far Eastern countries. In this study, FZ (125 mg/kg) was administered orally to Wistar rats for 3 days...
  30. Dani R, Queiroz D, Dias M, Franco J, Magalhaes L, Mendes G, et al. Omeprazole, clarithromycin and furazolidone for the eradication of Helicobacter pylori in patients with duodenal ulcer. Aliment Pharmacol Ther. 1999;13:1647-52 pubmed
    To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. Forty H...
  31. Li Y, Wang X, Shen S. [Efficacy of 4 kinds of triple strategy for Helicobacter pylori eradication]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33:1129-31 pubmed
    ..Group A was treated with rabeprazole, clarithromycin, and furazolidone (RCF); Group B with ranitidine bismuth citrate, clarithromycin, and furazolidone (BCF); Group C with ..
  32. Eisig J, Silva F, Barbuti R, Rodriguez T, Malfertheiner P, Moraes Filho J, et al. Efficacy of a 7-day course of furazolidone, levofloxacin, and lansoprazole after failed Helicobacter pylori eradication. BMC Gastroenterol. 2009;9:38 pubmed publisher
    ..The study aimed at determining the efficacy, compliance and adverse effects of a regimen that included furazolidone, levofloxacin and lansoprazole in patients with persistent Helicobacter pylori infection, who had failed to ..
  33. Sasaki N. Effects of furazolidone on duration of righting reflex loss induced with hexobarbital and zoxazolamine in the rat. J Vet Med Sci. 1994;56:667-70 pubmed
    Effects of furazolidone (FZ) on the sleeping time induced with hexobarbital (HEX) and paralysis time induced by zoxazolamine (ZOX) were investigated by measuring the length of time required to recover from righting reflex loss in rats ..
  34. Jiang X, Sun L, Qiu J, Sun X, Li S, Wang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS ONE. 2013;8:e72335 pubmed publisher
    ..b>Furazolidone (FZD) was shown to inhibit bone marrow transformation mediated by several leukemia fusion proteins, including ..
  35. Daghaghzadeh H, Emami M, Karimi S, Raeisi M. One-week versus two-week furazolidone-based quadruple therapy as the first-line treatment for Helicobacter pylori infection in Iran. J Gastroenterol Hepatol. 2007;22:1399-403 pubmed
    b>Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective although less tolerable...
  36. Malekzadeh R, Ansari R, Vahedi H, Siavoshi F, Alizadeh B, Eshraghian M, et al. Furazolidone versus metronidazole in quadruple therapy for eradication of Helicobacter pylori in duodenal ulcer disease. Aliment Pharmacol Ther. 2000;14:299-303 pubmed
    b>Furazolidone, an old but cheap antibiotic, was shown to be a good alternative to metronidazole in triple therapy for Helicobacter pylori eradication in areas where metronidazole resistant bacteria are common, but randomized studies are ..
  37. Lu H, Zhang D, Hu P, Li Z, Lu X, Fang X, et al. One-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline effectively eradicate Helicobacter pylori: a multicentre, randomized, double-blind study. Aliment Pharmacol Ther. 2001;15:1975-9 pubmed
    ..To evaluate the efficacy and safety of new 1-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline. One hundred and twenty patients with H...
  38. Hasan S, Vahid V, Reza P, Roham S. Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of Helicobacter pylori. Saudi J Gastroenterol. 2010;16:14-8 pubmed publisher
    ..The clarithromycin-based regimen is not cost-effective for use in developing countries. Though furazolidone is a great substitute it has many side effects...
  39. Timperio A, Kuiper H, Zolla L. Identification of a furazolidone metabolite responsible for the inhibition of amino oxidases. Xenobiotica. 2003;33:153-67 pubmed
    1 Furazolidone, a drug widely used in human and veterinary medicine, exhibits inhibition of monoamine oxidase activity, as observed in the tissues of a number of different animal species, including man...
  40. Xu C, Xiao L, Zou H. [Effect of birid triple viable on peptic ulcer patients with Helicobacter pylori infection]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:1000-4 pubmed publisher
    ..The control group was treated with the triple therapy including Esomeprazole, Amoxicillin, and Furazolidone. The treatment group was treated with the same triple therapy plus birid triple viable...
  41. Siavoshi F, Saniee P, Latifi Navid S, Massarrat S, Sheykholeslami A. Increase in resistance rates of H. pylori isolates to metronidazole and tetracycline--comparison of three 3-year studies. Arch Iran Med. 2010;13:177-87 pubmed
    ..5 microg/mL), clarithromycin (2 microg/mL), amoxicillin (1 microg/mL) and furazolidone (0.5 microg/mL)...
  42. Fakheri H, Merat S, Hosseini V, Malekzadeh R. Low-dose furazolidone in triple and quadruple regimens for Helicobacter pylori eradication. Aliment Pharmacol Ther. 2004;19:89-93 pubmed
    b>Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective. Unfortunately, the usual dose of furazolidone is not tolerable in many patients...
  43. Zullo A, Ierardi E, Hassan C, De Francesco V. Furazolidone-based therapies for Helicobacter pylori infection: a pooled-data analysis. Saudi J Gastroenterol. 2012;18:11-7 pubmed publisher
    b>Furazolidone-based therapies are used in developing countries to cure Helicobacter pylori infection due to its low cost...
  44. Gu L, Lin W, Lu H, Chen X, Ge Z, Li X. Quadruple therapy with medications containing either rufloxacin or furazolidone as a rescue regimen in the treatment of Helicobacter pylori-infected dyspepsia patients: a randomized pilot study. Helicobacter. 2011;16:284-8 pubmed publisher
    ..They were randomized to receive a 14-day quadruple therapy with pantoprazole, bismuth citrate, and furazolidone in combination with either rufloxacin (Group Ruf, n=70) or levofloxacin (Group Lev, n=68). The H...
  45. Ghadir M, Shafaghi A, Iranikhah A, Pakdin A, Joukar F, Mansour Ghanaei F. Furazolidone, amoxicillin and omeprazole with or without bismuth for eradication of Helicobacter pylori in peptic ulcer disease. Turk J Gastroenterol. 2011;22:1-5 pubmed
    b>Furazolidone has been introduced as an effective drug against Helicobacter pylori infection in Iran, but intolerable side effects may limit its use...
  46. Silva F, Eisig J, Chehter E, Silva J, Laudanna A. Omeprazole, furazolidone, and tetracycline: an eradication treatment for resistant H. pylori in Brazilian patients with peptic ulcer disease. Rev Hosp Clin Fac Med Sao Paulo. 2002;57:205-8 pubmed
    ..pylori) using omeprazole, tetracycline, and furazolidone in a Brazilian peptic ulcer population, divided into 2 subgroups: untreated and previously treated for the ..
  47. Machado R, Silva M, Viriato A. Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children. J Pediatr (Rio J). 2008;84:160-5 pubmed publisher
    To evaluate furazolidone, tetracycline and omeprazole as first line therapy for Helicobacter pylori in children with digestive symptoms. Prospective and consecutive open trial...
  48. López de Alba P, Lopez Martinez L, Wrobel K, Yepez Murrieta M, Amador Hernández J. Application of the bivariate spectrophotometric method for the determination of metronidazole, furazolidone and di-iodohydroxyquinoline in pharmaceutical formulations. J Pharm Biomed Anal. 1997;16:349-55 pubmed
    The bivariate calibration algorithm was applied to the spectrophotometric determination of metronidazole, furazolidone and di-iodohydroxyquinoline in pharmaceutical dosage forms...
  49. Gwathmey J, Kim C, Hajjar R, Khan F, DiSalvo T, Matsumori A, et al. Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol. Am J Physiol. 1999;276:H1678-90 pubmed
    Broad-breasted white turkey poults fed furazolidone developed dilated cardiomyopathy (DCM) characterized by ventricular dilatation, decreased ejection fraction, beta1-receptor density, sarcoplasmic reticulum (SR) Ca2+-ATPase, myofibrillar ..
  50. Ahmed H, El Aziem S, Abdel Wahhab M. Potential role of cysteine and methionine in the protection against hormonal imbalance and mutagenicity induced by furazolidone in female rats. Toxicology. 2008;243:31-42 pubmed
    ..b>Furazolidone (FUZ) is a nitrofuran drug, which has been used for many years as an antibacterial drug in veterinary practice...
  51. Cheng H, Hu F. Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori. World J Gastroenterol. 2009;15:860-4 pubmed
    To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori (H pylori)...
  52. Hu X, Xu Y, Yediler A. Determinations of residual furazolidone and its metabolite, 3-amino-2-oxazolidinone (AOZ), in fish feeds by HPLC-UV and LC-MS/MS, respectively. J Agric Food Chem. 2007;55:1144-9 pubmed
    The antibacterial drug furazolidone belonging to the group of nitrofuran antibacterial agents has been widely used as an antibacterial and antiprotozoal feed additive for poultry, cattle, and farmed fish in China...
  53. Navarro Rodriguez T, Silva F, Barbuti R, Mattar R, Moraes Filho J, De Oliveira M, et al. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study. BMC Gastroenterol. 2013;13:56 pubmed publisher
    ..If the first-line therapy fails a second-line treatment using tetracycline, furazolidone and proton-pump inhibitors has been effective and low cost in Brazil; however it implies in a lot of adverse ..