nystatin

Summary

Summary: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.

Top Publications

  1. Ates M, Akdeniz B, Sen B. The effect of calcium chelating or binding agents on Candida albicans. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:626-30 pubmed
    ..acid (EDTA), ethyleneglycol-tetraacetic acid (EGTA), sodium fluoride (NaF), titanium tetrafluoride (TiF4), nystatin, and ketoconazole. Minimum inhibitory and fungicidal concentrations of the solutions were determined...
  2. da Silva W, Rached R, Rosalen P, Del Bel Cury A. Effects of nystatin, fluconazole and propolis on poly(methyl methacrylate) resin surface. Braz Dent J. 2008;19:190-6 pubmed
    ..Therefore, the aim of this study was to evaluate the effects of fluconazole (FLU), nystatin (NYS) and propolis orabase gel (PRO) on poly (methyl-methacrylate) (PMMA) surfaces...
  3. Tewary P, Veena K, Pucadyil T, Chattopadhyay A, Madhubala R. The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages. Biochem Biophys Res Commun. 2006;339:661-6 pubmed
    ..We report here that cholesterol sequestration by the sterol-binding antifungal polyene antibiotic nystatin markedly inhibits binding and entry of non-opsonized L. donovani promastigotes into macrophages...
  4. Kovac M, Mitic G, Kovac Z. Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin. J Clin Pharm Ther. 2012;37:45-8 pubmed publisher
    ..10 case reports of interactions between oral anticoagulants and miconazole oral gel, but none so far between nystatin solution and anticoagulants...
  5. Kristanc L, Svetina S, Gomiscek G. Effects of the pore-forming agent nystatin on giant phospholipid vesicles. Biochim Biophys Acta. 2012;1818:636-44 pubmed publisher
    The effects of the polyene pore-forming agent nystatin were investigated on individual giant unilamellar phospholipid vesicles (GUVs), made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), in different methanol-water solutions ..
  6. Sekurova O, Brautaset T, Sletta H, Borgos S, Jakobsen M Ø, Ellingsen T, et al. In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. J Bacteriol. 2004;186:1345-54 pubmed
    Six putative regulatory genes are located at the flank of the nystatin biosynthetic gene cluster in Streptomyces noursei ATCC 11455...
  7. Aydemir C, Oguz S, Dizdar E, Akar M, Sarikabadayi Y, Saygan S, et al. Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed. 2011;96:F164-8 pubmed publisher
    ..The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low ..
  8. Croy S, Kwon G. The effects of Pluronic block copolymers on the aggregation state of nystatin. J Control Release. 2004;95:161-71 pubmed
    The purpose of this work was to characterize the effect of block copolymer composition on the aggregation state of nystatin in the presence of Pluronic micelles...
  9. Blot V, McGraw T. GLUT4 is internalized by a cholesterol-dependent nystatin-sensitive mechanism inhibited by insulin. EMBO J. 2006;25:5648-58 pubmed
    ..Approximately 80% of GLUT4 is internalized by a mechanism that is sensitive to the cholesterol-aggregating drug nystatin, and is independent of AP-2 clathrin adaptor and two putative GLUT4 endocytic motifs...

More Information

Publications62

  1. Bílková E, Imramovsky A, Buchta V, Sedlák M. Targeted antifungal delivery system: beta-glucosidase sensitive nystatin-star poly(ethylene glycol) conjugate. Int J Pharm. 2010;386:1-5 pubmed publisher
    A new targeted intravenous conjugate of nystatin with pentaerythritol poly(ethylene glycol)ether has been prepared and characterised (NY(4)-sPEG, M=25 160)...
  2. Urban V, de Souza R, Arrais C, Borsato K, Vaz L. Effect of the association of nystatin with a tissue conditioner on its ultimate tensile strength. J Prosthodont. 2006;15:295-9 pubmed
    This study evaluated the ultimate tensile strength of a tissue conditioner without nystatin incorporation (GI-control group) and the same tissue conditioner modified by the addition of nystatin in two concentrations: GII-500,000 ..
  3. Eggimann P, Wolff M, Garbino J. Oral nystatin as antifungal prophylaxis in critically ill patients: an old SDD tool to be renewed?. Intensive Care Med. 2005;31:1466-8 pubmed
  4. Khan M, Nasti T, Saima K, Mallick A, Firoz A, Wajahul H, et al. Co-administration of immunomodulator tuftsin and liposomised nystatin can combat less susceptible Candida albicans infection in temporarily neutropenic mice. FEMS Immunol Med Microbiol. 2004;41:249-58 pubmed
    ..The co-administration of tuftsin increased the efficiency of liposomised-polyene antibiotics (nystatin and amphotericin B) against experimental murine candidiasis in immunocompromised Balb/c mice...
  5. Rodighiero S, De Simoni A, Formenti A. The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques. Biochim Biophys Acta. 2004;1660:164-70 pubmed
    Human red blood cells (RBC) can be studied by means of whole-cell and nystatin-perforated patch-clamp techniques...
  6. Valitova J, Minibayeva F, Kotlova E, Novikov A, Shavarda A, Murtazina L, et al. Effects of sterol-binding agent nystatin on wheat roots: the changes in membrane permeability, sterols and glycoceramides. Phytochemistry. 2011;72:1751-9 pubmed publisher
    ..in membrane activity is to use agents that specifically bind with endogenous sterols, for example the antibiotic nystatin. Membrane characteristics and the composition of membrane lipids in the roots of wheat (Triticum aestivum L...
  7. Selinka H, Giroglou T, Sapp M. Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions. Virology. 2002;299:279-287 pubmed
    ..Together, our results suggest that binding of HPV pseudovirions to heparan sulfate proteoglycans, most likely syndecans, is followed by delayed internalization via the endosomal pathway. ..
  8. Lee M, Kong D, Han K, Sherman D, Bai L, Deng Z, et al. Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. Appl Microbiol Biotechnol. 2012;95:157-68 pubmed publisher
    Polyene antibiotics such as nystatin are a large family of very valuable antifungal polyketide compounds typically produced by soil actinomycetes...
  9. Wilson Ashworth H, Bahm Q, Erickson J, Shinkle A, Vu M, Woodbury D, et al. Differential detection of phospholipid fluidity, order, and spacing by fluorescence spectroscopy of bis-pyrene, prodan, nystatin, and merocyanine 540. Biophys J. 2006;91:4091-101 pubmed
    ..The fluorescent probes used (bis-pyrene, nystatin, prodan, and merocyanine) were chosen because they differ in the location they occupy in the membrane and in the ..
  10. Fernández Campos F, Clares Naveros B, López Serrano O, Alonso Merino C, Calpena Campmany A. Evaluation of novel nystatin nanoemulsion for skin candidosis infections. Mycoses. 2013;56:70-81 pubmed publisher
    ..The main aim of this work was to evaluate an optimal nystatin nanoemulsion for topical application avoiding undesirable side effects as systemic absorption and toxicity...
  11. Khan M, Aljarbou A, Khan A, Owais M. Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice. FEMS Immunol Med Microbiol. 2012;66:88-97 pubmed publisher
    ..neoformans to brain tissues. Moreover, the co-administration of tuftsin with nystatin liposomes augmented the anti-cryptococcal activity of nystatin, as mice treated with tuftsin-incorporated ..
  12. Sanchez S, Garcia P, Thomas K, Catlin M, Holmes K. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial. Am J Obstet Gynecol. 2004;191:1898-906 pubmed
    ..75% gel (containing 37.5 mg metronidazole per dose) with ovules containing metronidazole 500 mg and nystatin 100,000 U, for intravaginal treatment of bacterial vaginosis (BV)...
  13. Razonable R, Henault M, Watson H, Paya C. Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism. Antimicrob Agents Chemother. 2005;49:3546-9 pubmed
    b>Nystatin is an antifungal compound with potent proinflammatory properties...
  14. Van Leeuwen M, Golovina E, Dijksterhuis J. The polyene antimycotics nystatin and filipin disrupt the plasma membrane, whereas natamycin inhibits endocytosis in germinating conidia of Penicillium discolor. J Appl Microbiol. 2009;106:1908-18 pubmed publisher
    To investigate the differences in membrane permeability and the effect on endocytosis of the polyene antimycotics nystatin, filipin and natamycin on germinating fungal conidia...
  15. Fan S, Liu X. In vitro fluconazole and nystatin susceptibility and clinical outcome in complicated vulvovaginal candidosis. Mycoses. 2011;54:501-5 pubmed publisher
    To correlate fluconazole and nystatin susceptibility with clinical outcome for complicated vulvovaginal candidosis (VVC), 287 Candida isolates were collected from 283 patients with complicated VVC...
  16. Hombach J, Palmberger T, Bernkop Schnurch A. Development and in vitro evaluation of a mucoadhesive vaginal delivery system for nystatin. J Pharm Sci. 2009;98:555-64 pubmed publisher
    The purpose of the present study was to design and evaluate a novel vaginal delivery system for nystatin based on mucoadhesive polymers...
  17. Violaris K, Carbone T, Bateman D, Olawepo O, Doraiswamy B, LaCorte M. Comparison of fluconazole and nystatin oral suspensions for prophylaxis of systemic fungal infection in very low birthweight infants. Am J Perinatol. 2010;27:73-8 pubmed publisher
    We compared the efficacy and safety of fluconazole and nystatin oral suspensions for the prevention of systemic fungal infection (SFI) in very low birthweight infants...
  18. Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011;117:6392-403 pubmed publisher
    ..Intriguingly, cholesterol sequestration by nystatin, a polyene antifungal drug, significantly enhances endostatin uptake by endothelial cells through switching ..
  19. Chen Z, Yang C, He H, Zeng J. [The clinical research of nystatin in prevention of invasive fungal infections in patients on mechanical ventilation in intensive care unit]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013;25:475-8 pubmed publisher
    To observe the effect of nystatin on incidence of invasive fungal infections (IFI) and the prognosis of mechanically ventilated critically ill patients. A prospective study was conducted...
  20. Coutinho A, Silva L, Fedorov A, Prieto M. Cholesterol and ergosterol influence nystatin surface aggregation: relation to pore formation. Biophys J. 2004;87:3264-76 pubmed
    b>Nystatin interaction with liposomes mimicking fungal and mammalian membranes (ergosterol- and cholesterol-containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) large unilamellar vesicles, respectively) was studied by ..
  21. Pucadyil T, Shrivastava S, Chattopadhyay A. The sterol-binding antibiotic nystatin differentially modulates ligand binding of the bovine hippocampal serotonin1A receptor. Biochem Biophys Res Commun. 2004;320:557-62 pubmed
    ..of the bovine hippocampal 5-HT1A receptor following treatment with the sterol-binding antifungal antibiotic nystatin. Nystatin considerably inhibits the specific binding of the antagonist to 5-HT1A receptors in a concentration-..
  22. Ogawa Y, Mizumoto N, Tanaka H, Matsushima H, Takashima A. Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol. 2006;126:349-53 pubmed
    ..Here we report that nystatin (NYT), an antifungal drug of the family of polyene macrolide antibiotics, elevated YFP expression by the ..
  23. Foster L, de Hoog C, Mann M. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci U S A. 2003;100:5813-8 pubmed
    ..Our results provide the first large-scale and unbiased evidence, to our knowledge, for the connection of rafts with signaling and place limits on the fraction of plasma membrane composed by rafts. ..
  24. Wong P, Lo K, Tong G, Chan S, Lo M, Mak S, et al. Prevention of fungal peritonitis with nystatin prophylaxis in patients receiving CAPD. Perit Dial Int. 2007;27:531-6 pubmed
    ..The role of nystatin prophylaxis during antibiotic therapy in the prevention of FP remains controversial, especially in programs with ..
  25. Brautaset T, Sletta H, Degnes K, Sekurova O, Bakke I, Volokhan O, et al. New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei. Appl Environ Microbiol. 2011;77:6636-43 pubmed publisher
    Polyene macrolide antibiotics, including nystatin and amphotericin B, possess fungicidal activity and are being used as antifungal agents to treat both superficial and invasive fungal infections...
  26. Koide N, Naiki Y, Morikawa A, Tumurkhuu G, Dagvadorj J, Noman A, et al. Nystatin-induced nitric oxide production in mouse macrophage-like cell line RAW264.7. Microbiol Immunol. 2009;53:295-300 pubmed publisher
    b>Nystatin is known to deplete lipid rafts from mammalian cell membranes. Lipid rafts have been reported to be necessary for lipopolysaccharide signaling...
  27. Coutinho A, Prieto M. Cooperative partition model of nystatin interaction with phospholipid vesicles. Biophys J. 2003;84:3061-78 pubmed
    b>Nystatin is a membrane-active polyene antibiotic that is thought to kill fungal cells by forming ion-permeable channels...
  28. Normand S, Francois B, Dardé M, Bouteille B, Bonnivard M, Preux P, et al. Oral nystatin prophylaxis of Candida spp. colonization in ventilated critically ill patients. Intensive Care Med. 2005;31:1508-13 pubmed
    ..infection in intensive care unit (ICU) patients. We evaluated whether oral nystatin prophylaxis reduces Candida spp. colonization in ventilated ICU patients...
  29. Livraghi A, Mall M, Paradiso A, Boucher R, Ribeiro C. Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment. Am J Respir Cell Mol Biol. 2008;38:423-34 pubmed
    ..model of dysregulated Na(+) absorption by treating polarized normal human bronchial epithelial cells (HBEs) with nystatin (Nys), a polyene antibiotic that enables monovalent cations to permeate biological membranes...
  30. Liu G, Wang W, Sun G, Ma X, Liu Z, Yang J. Nystatin interferes with the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingolipid metabolism in human FL cells. Lipids. 2008;43:867-75 pubmed publisher
    ..On the other hand, the polyene antibiotic nystatin can block MNNG-induced receptor clustering...
  31. Zhang L, Zhang Y, Zhou Y, An S, Zhou Y, Cheng J. Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays. J Antimicrob Chemother. 2002;49:905-15 pubmed
    The response of the yeast Saccharomyces cerevisiae to two polyene antibiotics, amphotericin B and nystatin, was studied by genomic expression profiling...
  32. Al Jubory A, Handy R. Uptake of titanium from TiO? nanoparticle exposure in the isolated perfused intestine of rainbow trout: nystatin, vanadate and novel CO?-sensitive components. Nanotoxicology. 2013;7:1282-301 pubmed publisher
    ..8-fold reduction in the net uptake rate of Ti for TiO? NP exposure. Luminal additions of nystatin (endocytosis inhibitor), blocked the uptake of Ti from both bulk and TiO? NP treatments...
  33. Rosato A, Vitali C, Piarulli M, Mazzotta M, Argentieri M, Mallamaci R. In vitro synergic efficacy of the combination of Nystatin with the essential oils of Origanum vulgare and Pelargonium graveolens against some Candida species. Phytomedicine. 2009;16:972-5 pubmed publisher
    ..essential oils Origanum vulgare, Pelargonium graveolens and Melaleuca alternifolia and the antifungal compound Nystatin. Nystatin is considered a drug of choice in the treatment of fungal infections, but it can cause some ..
  34. Khan M, Syed F, Nasti H, Saima Dagger K, Haq W, Shehbaz A, et al. Use of tuftsin bearing nystatin liposomes against an isolate of Candida albicans showing less in vivo susceptibility to amphotericin B. J Drug Target. 2003;11:93-9 pubmed
    In the present study, we evaluated tuftsin bearing nystatin liposomes for their potential against an isolate of Candida albicans (C. albicans) showing less in vivo susceptibility to amphotericin B (Amp B)...
  35. Hac Wydro K, Dynarowicz Latka P. Interaction between nystatin and natural membrane lipids in Langmuir monolayers--the role of a phospholipid in the mechanism of polyenes mode of action. Biophys Chem. 2006;123:154-61 pubmed
    b>Nystatin (NYS), a polyene antifungal antibiotic, has been investigated in Langmuir monolayers alone and in mixtures with mammalian and fungi membrane sterols (cholesterol and ergosterol, respectively) as well as with a model phospholipid (..
  36. Woods O, Saliba I. Effect of nystatin on Guinea Pigs' inner ear. Neurotox Res. 2011;20:301-6 pubmed publisher
    b>Nystatin is a topical antifungal agent. Its wide spectrum of action and low cost make it a treatment of choice. Though it is safe for external ear use, no study has proven its safety in cases of tympanic membrane perforation (TMP)...
  37. Silva L, Coutinho A, Fedorov A, Prieto M. Nystatin-induced lipid vesicles permeabilization is strongly dependent on sterol structure. Biochim Biophys Acta. 2006;1758:452-9 pubmed
    The selectivity of the antibiotic nystatin towards ergosterol compared to cholesterol is believed to be a crucial factor in its specificity for fungi...
  38. te Welscher Y, ten Napel H, Balagué M, Souza C, Riezman H, de Kruijff B, et al. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. J Biol Chem. 2008;283:6393-401 pubmed publisher
    ..Other polyene antibiotics, like nystatin and filipin are known to interact with sterols, with some specificity for ergosterol thereby causing leakage of ..
  39. Ozturk M, Gunes T, Koklu E, Cetin N, Koc N. Oral nystatin prophylaxis to prevent invasive candidiasis in Neonatal Intensive Care Unit. Mycoses. 2006;49:484-92 pubmed
    The use of oral nystatin to prevent fungal colonisation and infection in neonates in the Neonatal Intensive Care Unit (NICU) is still an open question and not yet recommended as a standard of care...
  40. Silva L, Coutinho A, Fedorov A, Prieto M. Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study. Biophys J. 2006;90:3625-31 pubmed
    ..studies between cholesterol and ergosterol were carried out to gain insight into the binding interactions between nystatin and these sterols...
  41. Nasti T, Khan M, Owais M. Enhanced efficacy of pH-sensitive nystatin liposomes against Cryptococcus neoformans in murine model. J Antimicrob Chemother. 2006;57:349-52 pubmed
    To evaluate the efficacy of pH-sensitive liposomes of nystatin against Cryptococcus neoformans infection in a murine model...
  42. Muller M, Hollyoak M, Moaveni Z, Brown T, Herndon D, Heggers J. Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Burns. 2003;29:834-6 pubmed
    ..5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound surface areas were measured each three days...
  43. Katzman R, Longnecker R. Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein-Barr virus. J Gen Virol. 2003;84:2987-92 pubmed
    ..In this study, use of the cholesterol-binding drugs methyl-beta-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for ..
  44. Vitale R, Meis J, Mouton J, Verweij P. Evaluation of the post-antifungal effect (PAFE) of amphotericin B and nystatin against 30 zygomycetes using two different media. J Antimicrob Chemother. 2003;52:65-70 pubmed
    The post-antifungal effect (PAFE) of amphotericin B and nystatin against 30 clinical zygomycetes was evaluated using two different media. PAFE is a suppression of fungal growth after limited drug exposure...
  45. Urban V, Seo R, Giannini M, Arrais C. Superficial distribution and identification of antifungal/antimicrobial agents on a modified tissue conditioner by SEM-EDS microanalysis: a preliminary study. J Prosthodont. 2009;18:603-10 pubmed publisher
    ..The nystatin dosages incorporated into the tissue conditioner (Softone, Bosworth Co...
  46. Wallace T, Paetznick V, Cossum P, Lopez Berestein G, Rex J, Anaissie E. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997;41:2238-43 pubmed
    The purpose of this study was to examine the activity of liposomal nystatin against a disseminated Aspergillus fumigatus infection in neutropenic mice...
  47. Karpichev I, Cornivelli L, Small G. Multiple regulatory roles of a novel Saccharomyces cerevisiae protein, encoded by YOL002c, in lipid and phosphate metabolism. J Biol Chem. 2002;277:19609-17 pubmed
    ..These mutant cells are also resistant to the polyene antibiotic, nystatin. Gene chip analysis on yol002cDelta cells revealed that a variety of genes encoding proteins involved in fatty ..
  48. Charvalos E, Tsatsakis A, Tzatzarakis M, Dolapsakis G, Stiakakis J. New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with Fusarium oxysporum. Mycopathologia. 2002;153:15-9 pubmed
    Six water-soluble nystatin-polyvilnylpyrrolidone complexes with respective MW of 10 kDa (NC1), 25 kDa (NC2), 30 kDa (NC3), 40 kda (NC4), 90 kDa (NC5), 360 kDa (NC6) were synthesized...
  49. Jonsbu E, Christensen B, Nielsen J. Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture. Appl Microbiol Biotechnol. 2001;56:93-100 pubmed
    The central carbon metabolism of the nystatin-producing strain Streptomyces noursei ATCC 11455 was evaluated by 13C-labelling experiments...
  50. Brautaset T, Sekurova O, Sletta H, Ellingsen T, StrŁm A, Valla S, et al. Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. Chem Biol. 2000;7:395-403 pubmed
    The polyene macrolide antibiotic nystatin produced by Streptomyces noursei ATCC 11455 is an important antifungal agent...
  51. Zotchev S, Haugan K, Sekurova O, Sletta H, Ellingsen T, Valla S. Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455. Microbiology. 2000;146 ( Pt 3):611-9 pubmed
    Streptomyces noursei ATCC 11455 produces the antifungal polyene antibiotic nystatin containing the deoxysugar moiety mycosamine...
  52. Carrillo Munoz A, Quindos G, Tur C, Ruesga M, Miranda Y, del Valle O, et al. In-vitro antifungal activity of liposomal nystatin in comparison with nystatin, amphotericin B cholesteryl sulphate, liposomal amphotericin B, amphotericin B lipid complex, amphotericin B desoxycholate, fluconazole and itraconazole. J Antimicrob Chemother. 1999;44:397-401 pubmed
    The in-vitro susceptibilities of 120 clinical isolates of yeasts to liposomal nystatin were compared with those to amphotericin B lipid complex (ABLC), liposomal amphotericin B (LAB), amphotericin B cholesteryl sulphate (ABCD), ..
  53. Groll A, Just Nuebling G, Kurz M, Mueller C, Nowak Goettl U, Schwabe D, et al. Fluconazole versus nystatin in the prevention of candida infections in children and adolescents undergoing remission induction or consolidation chemotherapy for cancer. J Antimicrob Chemother. 1997;40:855-62 pubmed
    ..study was performed to assess the efficacy and safety of oral fluconazole 3 mg/kg once daily compared with oral nystatin 50,000 units/kg/day in four divided doses in preventing candida infections in 50 children undergoing remission ..