chalcones

Summary

Summary: Derivatives of CHALCONE that are important intermediates in the formation of FLAVONOIDS with anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties.

Top Publications

  1. Champelovier P, Chauchet X, Hazane Puch F, Vergnaud S, Garrel C, Laporte F, et al. Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects. Toxicol In Vitro. 2013;27:2305-15 pubmed publisher
    b>Chalcones are naturally occurring compounds with diverse pharmacological activities. Chalcones derive from the common structure: 1,3-diphenylpropenone...
  2. Shenvi S, Kumar K, Hatti K, Rijesh K, Diwakar L, Reddy G. Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: structure-activity relationship. Eur J Med Chem. 2013;62:435-42 pubmed publisher
    2,4,5-Trimethoxy chalcones and analogues were synthesized from asaronaldehyde derived from ?-asarone...
  3. Tadigoppula N, Korthikunta V, Gupta S, Kancharla P, Khaliq T, Soni A, et al. Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents. J Med Chem. 2013;56:31-45 pubmed publisher
    ..In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from Crotalaria medicagenia , which exhibited antimalarial activity ..
  4. Chow Y, Lee K, Vidyadaran S, Lajis N, Akhtar M, Israf D, et al. Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-?/LPS-stimulated BV2 microglia via NF-?B signalling pathway. Int Immunopharmacol. 2012;12:657-65 pubmed publisher
    ..Taken together, our experimental data provide mechanistic insights for the anti-inflammatory actions of cardamonin in BV2 and thus suggest a possible therapeutic application of cardamonin for targeting neuroinflammatory disorders. ..
  5. Sharma V, Singh G, Kaur H, Saxena A, Ishar M. Synthesis of ?-ionone derived chalcones as potent antimicrobial agents. Bioorg Med Chem Lett. 2012;22:6343-6 pubmed publisher
    A series of chalcones (3a-v) have been synthesized by condensation of ?-ionone (1) with a variety of aldehydes (2a-v)...
  6. Repanas A, Katsori A, Hadjipavlou Litina D. Chalcones in cancer: understanding their role in terms of QSAR. II part. Mini Rev Med Chem. 2013;13:952-70 pubmed
    b>Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family and possess a wide variety of cytoprotective and modulatory functions...
  7. Yuan X, Zhang B, Chen N, Chen X, Liu L, Zheng Q, et al. Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. J Asian Nat Prod Res. 2012;14:789-98 pubmed publisher
    ..Our findings suggested that ISL treatment induced apoptosis by increasing intracellular ROS levels in HeLa cells. ..
  8. Li L, Zhao X, Luo Y, Zhao J, Yang X, Zhang H. Novel cytotoxic chalcones from Litsea rubescens and Litsea pedunculata. Bioorg Med Chem Lett. 2011;21:7431-3 pubmed publisher
    ..The new chalcones were found to contain the rare epoxy or ethylidenedioxy group...
  9. Chiruta C, Schubert D, Dargusch R, Maher P. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012;55:378-89 pubmed publisher
    ..Here we describe a multitiered approach to screening that has allowed us to identify fisetin derivatives with significantly enhanced activity in an in vitro neuroprotection model while at the same time maintaining other key activities. ..

More Information

Publications62

  1. Robinson M, Overmeyer J, Young A, Erhardt P, Maltese W. Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death. J Med Chem. 2012;55:1940-56 pubmed publisher
    ..Thus, it may serve as a prototype for drugs that could be used to trigger death by methuosis in cancers that are resistant to conventional forms of cell death (e.g., apoptosis). ..
  2. Syam S, Abdelwahab S, Al Mamary M, Mohan S. Synthesis of chalcones with anticancer activities. Molecules. 2012;17:6179-95 pubmed publisher
    Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, ..
  3. Zhou G, Song L, Yang B. Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. Mol Med Rep. 2013;7:531-6 pubmed publisher
    ..These results indicate that cell cycle arrest and the caspase-mediated apoptosis pathway may participate in the antiproliferative activity of ISL in U87 cells by regulating the expression of specific molecules. ..
  4. Firoozpour L, Edraki N, Nakhjiri M, Emami S, Safavi M, Ardestani S, et al. Cytotoxic activity evaluation and QSAR study of chromene-based chalcones. Arch Pharm Res. 2012;35:2117-25 pubmed publisher
    ..The results indicate that type A of chromene-chalcones demonstrated better cytotoxic profile than type B especially in MDA-MB-231 cell line...
  5. Song N, Yoon H, Kim K, Jung S, Jang W, Seo C, et al. Butein is a novel anti-adipogenic compound. J Lipid Res. 2013;54:1385-96 pubmed publisher
  6. Lv H, Mo J, Fang X, Chi Y. Formal Diels-Alder reactions of chalcones and formylcyclopropanes catalyzed by chiral N-heterocyclic carbenes. Org Lett. 2011;13:5366-9 pubmed publisher
    Highly enantioselective (formal) hetero-Diels-Alder reactions between chalcones and formylcyclopropanes are disclosed...
  7. Warmka J, Solberg E, Zeliadt N, Srinivasan B, Charlson A, Xing C, et al. Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog. Biochem Biophys Res Commun. 2012;424:488-92 pubmed publisher
    We are interested in investigating the biological activity of chalcones, a major class of compounds found in the beverage kava, in order to develop potent and selective chemopreventive candidates...
  8. Juvale K, Pape V, Wiese M. Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorg Med Chem. 2012;20:346-55 pubmed publisher
    ..The aim of the current study was to investigate different multi-substituted chalcones for their BCRP inhibition. We synthesized chalcones and benzochalcones with different substituents (viz...
  9. Khan N, Adhami V, Afaq F, Mukhtar H. Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. Antioxid Redox Signal. 2012;16:1195-204 pubmed publisher
    ..For the first time, we have shown that butein caused inhibition of prostate tumor growth in-vivo. We suggest that butein could be developed as an agent against PCa. Antioxid. Redox Signal. 16, 1195-1204. ..
  10. Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day B, Winnischofer S, et al. Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. J Med Chem. 2012;55:3193-200 pubmed publisher
    ..Potent and selective ABCG2 inhibitors with low cytotoxicity were investigated among a series of 44 chalcones and analogues (1,3-diarylpropenones), by evaluating their inhibitory effect on the transport of mitoxantrone, a ..
  11. Neves M, Cravo S, Lima R, Vasconcelos M, Nascimento M, Silva A, et al. Solid-phase synthesis of 2'-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines. Bioorg Med Chem. 2012;20:25-33 pubmed publisher
    ..b>Chalcones were tested for their growth inhibitory activity in three human tumor cell lines (MCF-7, NCI-H460 and A375-C5) ..
  12. Aryapour H, Riazi G, Ahmadian S, Foroumadi A, Mahdavi M, Emami S. Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones. Pharm Biol. 2012;50:1551-60 pubmed publisher
    ..A series of chromene-based chalcones with chlorine, methoxy, fluorine, tetrahydropyranyloxy and cyanide substituents were prepared and evaluated for ..
  13. Oracz K, Voegele A, Tarkowska D, Jacquemoud D, Turecková V, Urbanová T, et al. Myrigalone A inhibits Lepidium sativum seed germination by interference with gibberellin metabolism and apoplastic superoxide production required for embryo extension growth and endosperm rupture. Plant Cell Physiol. 2012;53:81-95 pubmed publisher
    ..MyA negatively affected both of these processes and acted as a scavenger of apoplastic reactive oxygen species. We propose that MyA is an allelochemical with a novel mode of action on seed germination...
  14. Chiaradia L, Martins P, Cordeiro M, Guido R, Ecco G, Andricopulo A, et al. Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB). J Med Chem. 2012;55:390-402 pubmed publisher
    ..In this work, 100 chalcones were designed, synthesized, and investigated for their inhibitory properties against MtbPtps...
  15. Amslinger S, Al Rifai N, Winter K, Wörmann K, Scholz R, Baumeister P, et al. Reactivity assessment of chalcones by a kinetic thiol assay. Org Biomol Chem. 2013;11:549-54 pubmed publisher
    The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other ?,?-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes...
  16. Orlikova B, Schnekenburger M, Zloh M, Golais F, Diederich M, Tasdemir D. Natural chalcones as dual inhibitors of HDACs and NF-?B. Oncol Rep. 2012;28:797-805 pubmed publisher
    ..Using a fluorescence assay, we tested the in vitro HDAC inhibitory activity of twenty-one natural chalcones, a widespread group of natural products with well-known anti-inflammatory and antitumor effects...
  17. Moreira Osório T, Delle Monache F, Domeneghini Chiaradia L, Mascarello A, Regina Stumpf T, Roberto Zanetti C, et al. Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2012;22:225-30 pubmed publisher
    ..In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and ..
  18. Mielcke T, Mascarello A, Filippi Chiela E, Zanin R, Lenz G, Leal P, et al. Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation. Eur J Med Chem. 2012;48:255-64 pubmed publisher
    ..pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention, including chalcones. In the present study, eight synthetic quinoxaline-derived chalcones, structurally based on the selective PI3K? ..
  19. Srivastava S, Sonkar R, Mishra S, Tiwari A, Balaramnavar V, Balramnavar V, et al. Antidyslipidemic and antioxidant effects of novel Lupeol-derived chalcones. Lipids. 2013;48:1017-27 pubmed publisher
    A series of Lupeol-based chalcones have been synthesized aiming to enhance the therapeutic efficacy of parent compound, the novel compounds were evaluated for their antidyslipidemic activity in triton-WR 1339 induced hyperlipidemic rats...
  20. Yuan X, Yu B, Wang Y, Jiang J, Liu L, Zhao H, et al. Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. Recent Pat Anticancer Drug Discov. 2013;8:191-9 pubmed
    ..ISL induces apoptosis via ER stress-triggered signaling pathways in SKOV-3 cells. ER stress-induced cancer cell apoptosis has been discussed in some patents. ..
  21. Bajgai S, Prachyawarakorn V, Mahidol C, Ruchirawat S, Kittakoop P. Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis. Phytochemistry. 2011;72:2062-7 pubmed publisher
    Hybrid flavan-chalcones, desmosflavans A (1) and B (2), together with three known compounds, cardamonin (3), pinocembrin (4) and chrysin (5), were isolated from leaves of Desmos cochinchinensis...
  22. Sohn J, Han K, Lee S, Hwang J. Protective effects of panduratin A against oxidative damage of tert-butylhydroperoxide in human HepG2 cells. Biol Pharm Bull. 2005;28:1083-6 pubmed
    ..It was also found that panduratin A reduced intracellular ROS formation caused by t-BHP. These results strongly suggest that panduratin A has significant protective ability against oxidative damage caused by reactive intermediates...
  23. Orlikova B, Tasdemir D, Golais F, Dicato M, Diederich M. The aromatic ketone 4'-hydroxychalcone inhibits TNF?-induced NF-?B activation via proteasome inhibition. Biochem Pharmacol. 2011;82:620-31 pubmed publisher
    b>Chalcones are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-cancer activities. The aim of this study was to investigate the anti-inflammatory and anti-cancer activity of 4'-hydroxychalcone...
  24. Messier C, Grenier D. Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans. Mycoses. 2011;54:e801-6 pubmed publisher
    ..albicans. These results suggest a therapeutic potential of licochalcone A and glabridin for C. albicans oral infections. ..
  25. Wu X, Tiekink E, Kostetski I, Kocherginsky N, Tan A, Khoo S, et al. Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene. Eur J Pharm Sci. 2006;27:175-87 pubmed
    A series of ferrocenyl chalcones were synthesized and evaluated in vitro against Plasmodium falciparum (K1) in a [3H] hypoxanthine uptake assay...
  26. Pandey M, Sandur S, Sung B, Sethi G, Kunnumakkara A, Aggarwal B. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. J Biol Chem. 2007;282:17340-50 pubmed
    ..Overall, our results indicated that antitumor and anti-inflammatory activities previously assigned to butein may be mediated in part through the direct inhibition of IKK, leading to the suppression of the NF-kappaB activation pathway. ..
  27. Ono M, Haratake M, Mori H, Nakayama M. Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains. Bioorg Med Chem. 2007;15:6802-9 pubmed
    ..The radioiodinated chalcones were successfully prepared through an iododestannylation reaction from the corresponding tributyltin derivatives ..
  28. Lahtchev K, Batovska D, Parushev S, Ubiyvovk V, Sibirny A. Antifungal activity of chalcones: a mechanistic study using various yeast strains. Eur J Med Chem. 2008;43:2220-8 pubmed publisher
    We reported the synthesis, antifungal evaluation and study on substituent effects of 21 chalcones. A lot of genetically defined strains belonging to different yeast genera and species, namely Saccharomyces cerevisiae, Hansenula ..
  29. Damazio R, Zanatta A, Cazarolli L, Chiaradia L, Mascarello A, Nunes R, et al. Antihyperglycemic activity of naphthylchalcones. Eur J Med Chem. 2010;45:1332-7 pubmed publisher
    ..In addition, chalcones 2 and 4 stimulated significantly the insulin secretion induced by glucose...
  30. Aponte J, Castillo D, Estevez Y, Gonzalez G, Arevalo J, Hammond G, et al. In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones. Bioorg Med Chem Lett. 2010;20:100-3 pubmed publisher
    The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent ..
  31. Rukayadi Y, Lee K, Han S, Yong D, Hwang J. In vitro activities of panduratin A against clinical Staphylococcus strains. Antimicrob Agents Chemother. 2009;53:4529-32 pubmed publisher
    ..Panduratin A had a MIC at which 90% of bacteria were inhibited of 1 microg/ml for clinical staphylococcal isolates and generally was more potent than commonly used antimicrobials...
  32. Cariou B, Zair Y, Staels B, Bruckert E. Effects of the new dual PPAR ?/? agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care. 2011;34:2008-14 pubmed publisher
    ..1% [-? to -1.1], P = 0.004). No specific adverse safety signals were reported during the studies. GFT505 may be considered a new drug candidate for the treatment of lipid and glucose disorders associated with the metabolic syndrome. ..
  33. Hatziieremia S, Gray A, Ferro V, Paul A, Plevin R. The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFkappaB signalling pathways in monocytes/macrophages. Br J Pharmacol. 2006;149:188-98 pubmed
    ..However, although some selectivity in cardamonin's action is implicated by its inability to affect COX-2 expression, its exact mechanism(s) of action has yet to be identified. ..
  34. Kondo K, Shiba M, Nakamura R, Morota T, Shoyama Y. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Biol Pharm Bull. 2007;30:1271-7 pubmed
    ..However, since 6% of licorice examined and hybrids were exceptions to the rule, their genetic information is necessary for the accurate species identification of licorice...
  35. Vogel S, Ohmayer S, Brunner G, Heilmann J. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity. Bioorg Med Chem. 2008;16:4286-93 pubmed publisher
    A general strategy for the synthesis of 3'-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop (Humulus lupulus L...
  36. Lee C, Son S, Park K, Park J, Lim S, Kim S, et al. Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice. Basic Clin Pharmacol Toxicol. 2008;103:48-54 pubmed publisher
    ..These results suggest that supplementation with LCA may be beneficial in counteracting the side effects of cisplatin therapy in cancer patients. ..
  37. Romagnoli R, Baraldi P, Carrion M, Cruz Lopez O, Cara C, Balzarini J, et al. Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2009;19:2022-8 pubmed publisher
    Research into the anti-tumor properties of chalcones has received significant attention over the last few years Two novel large series of alpha-bromoacryloylamido chalcones 1a-m and 2a-k containing a pair of Michael acceptors in their ..
  38. Boumendjel A, Ronot X, Boutonnat J. Chalcones derivatives acting as cell cycle blockers: potential anti cancer drugs?. Curr Drug Targets. 2009;10:363-71 pubmed
    b>Chalcones (1,3-diphenylpropen-1-ones) are naturally occurring compounds belonging to the flavonoid family and are largely investigated in various therapeutic area and especially as antitumor drugs...
  39. Ducki S, Rennison D, Woo M, Kendall A, Chabert J, McGown A, et al. Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. Bioorg Med Chem. 2009;17:7698-710 pubmed publisher
    ..Upon treatment with SD400, remarkable cell shape changes were elicited in HUVEC cells, consistent with vasculature damaging activity. ..
  40. Qiu J, Feng H, Xiang H, Wang D, Xia L, Jiang Y, et al. Influence of subinhibitory concentrations of licochalcone A on the secretion of enterotoxins A and B by Staphylococcus aureus. FEMS Microbiol Lett. 2010;307:135-41 pubmed publisher
    ..aureus and methicillin-resistant S. aureus. These results may increase the desirability of using licochalcone A as a lead compound for the design of more potent antibacterial agents based on the chalcone template. ..
  41. Sivakumar P, Prabhawathi V, Doble M. Antibacterial activity and QSAR of chalcones against biofilm-producing bacteria isolated from marine waters. SAR QSAR Environ Res. 2010;21:247-63 pubmed publisher
    ..Among the spatial descriptors, Jurs descriptors showed their contribution in all the three antibacterial QSARs. ..
  42. Szliszka E, Czuba Z, Mazur B, Paradysz A, Krol W. Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells. Molecules. 2010;15:5336-53 pubmed publisher
    b>Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent...
  43. Lee Y, Lim D, Choi H, Jung J, Chung W, Park J. Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. J Med Food. 2009;12:8-14 pubmed publisher
    ..We demonstrate that ISL promotes cell cycle arrest in DU145 and MLL cells, thereby providing insights into the mechanisms underlying its antitumorigenic activities...
  44. Ye L, Gho W, Chan F, Chen S, Leung L. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. Int J Cancer. 2009;124:1028-36 pubmed publisher
    ..3 and II was suppressed in these cells. Deactivation of C/EBP could be the underlying molecular mechanism. Our study demonstrated that ILN was an inhibitor of aromatase and a potential chemopreventive agent against breast cancer. ..
  45. Nobre Júnior H, Oliveira R, Maia F, Nogueira M, de Moraes M, Bandeira M, et al. Neuroprotective effects of chalcones from Myracrodruon urundeuva on 6-hydroxydopamine-induced cytotoxicity in rat mesencephalic cells. Neurochem Res. 2009;34:1066-75 pubmed publisher
    ..All together, our results demonstrated neuroprotective effects of chalcones, which are able to reduce oxidative stress and apoptotic injury caused by 6-OHDA...
  46. Batovska D, Todorova I. Trends in utilization of the pharmacological potential of chalcones. Curr Clin Pharmacol. 2010;5:1-29 pubmed
    b>Chalcones (1,3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act as attractants to the pollinators...
  47. Gacche R, Dhole N, Kamble S, Bandgar B. In-vitro evaluation of selected chalcones for antioxidant activity. J Enzyme Inhib Med Chem. 2008;23:28-31 pubmed
    Synthetic chalcones (SCs) having different side chains on the 1-(2-Hydroxy-3-(2-hydroxy-cyclohexyl)-4,6 dimethoxy-phenyl(-methanone structure were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine)..
  48. Liu X, Go M. Antiproliferative activity of chalcones with basic functionalities. Bioorg Med Chem. 2007;15:7021-34 pubmed
    A library of chalcones with different basic groups were synthesized and evaluated for antiproliferative activities against the human breast cancer (MCF 7) and colon cancer (HCT 116) cell lines...
  49. Xiao X, Hao M, Yang X, Ba Q, Li M, Ni S, et al. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis. Cancer Lett. 2011;302:69-75 pubmed publisher
    ..In addition, LCA-induced apoptosis by its effects on the expression of PARP, caspase-3, Bcl-2 and Bax. These data provide evidence that LCA has the potential to be used in the treatment of gastric cancer. ..
  50. Cheah S, Appleton D, Lee S, Lam M, Hadi A, Mustafa M. Panduratin A inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-kappaB translocation. Molecules. 2011;16:2583-98 pubmed publisher
    ..Our study provides evidence for cell growth inhibition and induction of apoptosis by panduratin A in the A549 cell line, suggesting its therapeutic potential as an NF-?B inhibitor. ..
  51. Chiaradia L, dos Santos R, Vitor C, Vieira A, Leal P, Nunes R, et al. Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: quantitative structure-activity relationships. Bioorg Med Chem. 2008;16:658-67 pubmed
    ..In the search for hits to obtain lead compounds for new drugs of this class, 14 synthetic chalcones derived from 2,4,6-trimethoxyacetophenone were evaluated in terms of their inhibitory action, in vitro, in ..
  52. Lee C, Kim H, Kim H, Kim J, Yoon J, Cho Y, et al. Inhibitory effect of panduratin A isolated from Kaempferia panduarata Roxb. on melanin biosynthesis. Phytother Res. 2010;24:1600-4 pubmed publisher
    ..These results indicate that panduratin A effectively inhibits melanin biosynthesis, thus creating the possibility of developing a new skin-whitening agent...
  53. Kozlowski D, Trouillas P, Calliste C, Marsal P, Lazzaroni R, Duroux J. Density functional theory study of the conformational, electronic, and antioxidant properties of natural chalcones. J Phys Chem A. 2007;111:1138-45 pubmed
    b>Chalcones are natural compounds that are largely distributed in plants, fruits, and vegetables. They belong to the flavonoid group of molecules, and some of them exhibit numerous biological activities...