Summary: Chelating agent and inhibitor of cellular respiration.

Top Publications

  1. Maind S, Kumar S, Chattopadhyay N, Gandhi C, Sudersanan M. Analysis of Indian blue ballpoint pen inks tagged with rare-earth thenoyltrifluoroacetonates by inductively coupled plasma-mass spectrometry and instrumental neutron activation analysis. Forensic Sci Int. 2006;159:32-42 pubmed
    ..The advantages and limitations of proposed analytical techniques are discussed. ..
  2. van Leeuwen F, Verboom W, Reinhoudt D. Selective extraction of naturally occurring radioactive Ra2+. Chem Soc Rev. 2005;34:753-61 pubmed
    ..This tutorial review deals with the selective extraction of the highly radiotoxic Ra2+. Special attention is paid to different types of organic extractants used. ..
  3. Zhang J, Fariss M. Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol. 2002;63:751-4 pubmed
    b>Thenoyltrifluoroacetone (TTFA), a conventional mitochondrial complex II inhibitor, was found to inhibit purified porcine liver carboxylesterase non-competitively with a K(i) of 0.61x10(-6)M and an IC(50) of 0.54x10(-6)M...
  4. Hadjichristov G, Stefanov I, Stanimirov S, Petkov I. The luminescence response of Eu(III)-thenoyltrifluoroacetonate complexes upon preresonant excitation with femtosecond laser pulses. Spectrochim Acta A Mol Biomol Spectrosc. 2010;75:448-52 pubmed publisher
  5. Qin P, Niu C, Zeng G, Ruan M, Tang L, Gong J. Time-resolved fluorescence based DNA detection using novel europium ternary complex doped silica nanoparticles. Talanta. 2009;80:991-5 pubmed publisher
    ..This approach was successfully employed for preliminary application in the detection of pure cultured E. coli, it might be an effective tool for pathogen DNA monitoring. ..
  6. Zheng N, Fung E, Buzescu A, Arnold M, Zeng J. Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2012;26:1291-304 pubmed publisher
    ..20 mM of diisopropylfluorophosphate (DFP), paraoxon, eserine, phenylmethylsulfonyl fluoride (PMSF) or 2-thenoyltrifluoroacetone (TTFA) was extracted by liquid-liquid extraction (LLE) and analyzed by an LC/MS/MS assay for BMS-068645 (..
  7. Sethi A, Lees D, Douthwaite J, Dawnay A, Corder R. Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. J Vasc Res. 2006;43:175-83 pubmed
    ..To investigate the role of mitochondrial metabolism in ROS production, cells were incubated with thenoyltrifluoroacetone (inhibitor of complex II) or carbonyl cyanide m-chlorophenylhydrazone (uncoupler of oxidative ..
  8. Nadanaciva S, Bernal A, Aggeler R, Capaldi R, Will Y. Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicol In Vitro. 2007;21:902-11 pubmed
    ..A major advantage of the immunocapture approach is that it can be used throughout drug screening from early compound evaluation to clinical trials. ..
  9. Indo H, Davidson M, Yen H, Suenaga S, Tomita K, Nishii T, et al. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion. 2007;7:106-18 pubmed
    ..ETC inhibitors (rotenone, 3-nitropropionic acid, thenoyltrifluoroacetone, antimycin A and sodium cyanide) were also tested to determine whether inhibitor treatment increased ..

More Information


  1. Lemarie A, Huc L, Pazarentzos E, Mahul Mellier A, Grimm S. Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction. Cell Death Differ. 2011;18:338-49 pubmed publisher
    ..This is achieved by the pH(i) decline that leads to the specific dissociation of the SDHA/SDHB subunits, which encompass the SDH activity, from the membrane-bound components of complex II that are required for the SQR activity. ..
  2. Dröse S, Bleier L, Brandt U. A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production. Mol Pharmacol. 2011;79:814-22 pubmed publisher
  3. Zheng Z, Yang Y, Shao H, Liu Z, Lu X, Xu Y, et al. Two thiophenes compounds are partial peroxisome proliferator-activated receptor ?/? dual agonists. Biol Pharm Bull. 2011;34:1631-4 pubmed
    ..These data indicate that the two thiophene derivatives are novel class of partial PPAR?/? dual agonists, which may be the mechanism underlying their regulatory effects on glucose homeostasis. ..
  4. Quagliaro L, Piconi L, Assaloni R, Da Ros R, Szabo C, Ceriello A. Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC. Nutr Metab Cardiovasc Dis. 2007;17:257-67 pubmed
    ..BH4), the peroxynitrite decomposition catalyst FP15, the inhibitor of mitochondrial complex II thenoyltrifluoroacetone (TTFA) and the antioxidant superoxide dismutase (SOD) mimetic Mn(III)tetrakis(4-benzoic acid) porphyrin ..
  5. Bera T, Nandi N, Sudhahar D, Akbar M, Sen A, Das P. Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance. J Bioenerg Biomembr. 2006;38:299-308 pubmed
    ..The iron-sulphur centre inhibitor thenoyltrifluoroacetone failed to inhibit the reduction of non permeable electron acceptors whereas capsaicin, an inhibitor of ..
  6. Berridge M, Tan A. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys. 1993;303:474-82 pubmed
    ..We conclude that most cellular reduction of MTT occurs extramitochondrially and probably involves the pyridine nucleotide cofactors NADH and NADPH. ..
  7. Sun J, Xu Y, Deng H, Sun S, Dai Z, Sun Y. Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes. J Mol Endocrinol. 2010;44:179-85 pubmed publisher the presence or in the absence of Mn(III) tetrakis(4-benzoic acid) porphyrin chloride (MnTBAP) or thenoyltrifluoroacetone (TTFA)...
  8. Zmijewski J, Moellering D, Le Goffe C, Landar A, Ramachandran A, Darley Usmar V. Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. Am J Physiol Heart Circ Physiol. 2005;289:H852-61 pubmed
    ..Taken together, these results suggest that oxLDL-dependent DCF fluorescence is mitochondrially associated and may be due to the formation of peroxynitrite. ..
  9. Menzel E, Bouldin K, Murdock R. Trace explosives detection by photoluminescence. ScientificWorldJournal. 2004;4:55-66 pubmed
  10. Guo C, Wu X, Xu W, Yang J. Resonance light-scattering enhancement effect of the protein-Y3+-TTA-SLS system and its analytical application. Luminescence. 2008;23:404-9 pubmed publisher
    ..In the Tris-HCl (pH 7.50) buffer, protein enhanced the RLS intensity of the Y(3+)-2-thenoyltrifluoroacetone (TTA)-sodium dodecyl sulphate (SLS) system...
  11. Carter C, Cao L, Kawai H, Smith P, Dryden W, Raftery M, et al. Chain length dependence of the interactions of bisquaternary ligands with the Torpedo nicotinic acetylcholine receptor. Biochem Pharmacol. 2007;73:417-26 pubmed
    ..Based on estimates of interonium distances, we suggest that bisquaternary ligands can interact with multiple binding sites on the nAChR and, depending on the conformational state of the receptor, these sites are 15-20A apart. ..
  12. Xu W, Bai X, Zhu Y, Liu T, Xu S, Dong B, et al. Communication: excitation band modulation with high-order photonic band gap in PMMA:Eu(TTA)3(TPPO)2 opals. J Chem Phys. 2013;138:181103 pubmed publisher
    ..We find shifts in the complex excitation band and changes in the integrated emission intensity that correlates with shifts in the high-order PBG through coupling to the excitation transition...
  13. Chen M, Andersen L, Zhai L, Kharazmi A. Characterization of the respiratory chain of Helicobacter pylori. FEMS Immunol Med Microbiol. 1999;24:169-74 pubmed
    ..The activity of NADH-FRD was inhibited by 2-thenoyltrifluoroacetone. A tentative scheme for the electron transfer pathway in H...
  14. Zhang J, Tirmenstein M, Nicholls Grzemski F, Fariss M. Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. Arch Biochem Biophys. 2001;393:87-96 pubmed
    ..The toxic effects of mitochondrial complex I and II inhibitors, rotenone (ROT) and thenoyltrifluoroacetone (TTFA), respectively, were dependent on oxidative stress and lipid peroxidation, while cell death induced ..
  15. Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, et al. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes. 2003;52:2570-7 pubmed
    ..production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression ..
  16. Moreno Sanchez R, Hernández Esquivel L, Rivero Segura N, Marin Hernandez A, Neuzil J, Ralph S, et al. Reactive oxygen species are generated by the respiratory complex II--evidence for lack of contribution of the reverse electron flow in complex I. FEBS J. 2013;280:927-38 pubmed publisher
    ..Here, we show that the CII Q site inhibitor thenoyltrifluoroacetone (TTFA) blocks succinate + rotenone-driven ROS production, whereas the complex III (CIII) Qo inhibitor ..
  17. Itoh Y, Ueda Y, Sugawara M, Kataoka M, Sato H, Umezawa Y. Nitrogenous synergists induced potentiometric response to metal ions with polymeric liquid membranes containing thenoyltrifluoroacetone as an ionophore. Anal Sci. 2006;22:219-23 pubmed divalent transition metal ions were investigated concerning polymeric liquid membranes containing thenoyltrifluoroacetone (Htta) as an ionophore. The tested synergists were pyridine (py) and 4,4'-dioctyl-2,2'-bipyridyl (C8bpy)...
  18. Doring O, Lüthje S. Inhibition of trans-membrane hexacyanoferrate III reductase activity and proton secretion of maize (Zea mays L.) roots by thenoyltrifluoroacetone. Protoplasma. 2001;217:3-8 pubmed
    ..Application of 4,4,4-trifluoro-1-(2-thienyl)-butane-1,3-dione (thenoyltrifluoroacetone) inhibited the reduction of ferricyanide in the incubation solution of intact maize roots up to 70%...
  19. Araújo A, Brito H, Malta O, Matos J, Teotonio E, Storpirtis S, et al. Synthesis and photophysical study of highly luminescent coordination compounds of rare earth ions with thenoyltrifluoroacetonate and AZT. J Inorg Biochem. 2002;88:87-93 pubmed
    ..Luminescence data confirm that the AZT complex and precursor compound have a comparable emission quantum efficiency. ..
  20. Li Y, Yan B. Photoactive europium(III) centered mesoporous hybrids with 2-thenoyltrifluoroacetone functionalized SBA-16 and organic polymers. Dalton Trans. 2010;39:2554-62 pubmed publisher
    ..mesoporous polymeric hybrids TTFA-S16-Eu-PMMA, TTFA-S16-Eu-PMAA, and TTFA-S16-Eu-PVP (TTFA = 2-Thenoyltrifluoroacetone; PMMA = polymethyl methacrylate; PMAA = polymethacrylic acid; PVP = polyvinylpyrrolidone) have been ..
  21. Ishiguro H, Yasuda K, Ishii N, Ihara K, Ohkubo T, Hiyoshi M, et al. Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors. IUBMB Life. 2001;51:263-8 pubmed
    ..Oxygen loading enhanced the damage of PC 12 cells by thenoyltrifluoroacetone (TTFA, a complex II inhibitor), but did not by rotenone (a complex I inhibitor), antimycin (a complex III ..
  22. Byun H, Kim H, Lim J, Seo Y, Yoon G. Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production. J Cell Biochem. 2008;104:1747-59 pubmed publisher, we investigated the effect of complex II inhibition using a subcytotoxic dose (400 microM) of 2-thenoyltrifluoroacetone (TTFA), a conventional complex II inhibitor, on cell cycle progression...
  23. Yamagishi S, Edelstein D, Du X, Brownlee M. Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction. Diabetes. 2001;50:1491-4 pubmed
    ..b>Thenoyltrifluoroacetone (TTFA), an inhibitor of mitochondrial electron transport chain complex II, and carbonyl cyanide m-..
  24. Jia Z, Yang J, Wu X, Sun C, Liu S, Wang F, et al. The sensitive determination of nucleic acids using resonance light scattering quenching method. Spectrochim Acta A Mol Biomol Spectrosc. 2006;64:555-9 pubmed
    ..03, 0.006 and 0.002 ng ml-1, respectively. Therefore, the proposed method is the most sensitive RLS method for the determination of nucleic acids so far. The interaction between nucleic acids and Eu3+-TTA-Phen is also discussed. ..
  25. Jia Z, Yang J, Wu X, Sun C, Wang F, Liu S, et al. The sensitive determination of nucleic acids using a fluorescence-quenching method. Luminescence. 2006;21:207-13 pubmed
    Experiments indicated that nucleic acids can quench the fluorescence of the Eu3+ -2-thenoyltrifluoroacetone (TTA)-1,10-phenanthroline (Phen) system. Based on this, a sensitive method for the determination of nucleic acids was proposed...
  26. Paddenberg R, Ishaq B, Goldenberg A, Faulhammer P, Rose F, Weissmann N, et al. Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol. 2003;284:L710-9 pubmed
    ..Presumably, its catalytic activity switches from succinate dehydrogenase to fumarate reductase at reduced oxygen tension, thereby modulating the directionality of the electron flow. ..
  27. Xu C, Li B, Wan J, Bu Z. Synthesis and characterization of a Eu-containing polymer precursor featuring thenoyltrifluoroacetone and 5-acrylamido-1,10-phenanthroline. Spectrochim Acta A Mol Biomol Spectrosc. 2011;82:159-63 pubmed publisher
    A polymerizable ligand, 5-acrylamido-1,10-phenanthroline (L), was synthesized. Its Eu(III) complex with 2-thenoyltrifluoroacetone (HTTA) was prepared and characterized by elemental analysis, IR, MS, and (1)H NMR spectra...
  28. González Aragón D, Ariza J, Villalba J. Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells. Biochem Pharmacol. 2007;73:427-39 pubmed
    ..Superoxide generation in cells was strongly potentiated by blocking the quinone site of Complex II with thenoyltrifluoroacetone, supporting the involvement of cytochrome b560 to drive electrons for increasing superoxide...
  29. Zhao J, Liu J, Pang X, Wang S, Wu D, Zhang X, et al. Angiotensin II induces C-reactive protein expression via AT1-ROS-MAPK-NF-?B signal pathway in hepatocytes. Cell Physiol Biochem. 2013;32:569-80 pubmed publisher
    ..Losartan reduced Ang II- induced CRP expression in hepatocytes. Losartan and thenoyltrifluoroacetone decreased Ang II-stimulated ROS production. N-acetylcysteine antagonized Ang II-induced CRP expression...
  30. Chen Z, Wu Y, Huang F, Gu D, Gan F. Synthesis, spectral, and thermal characterizations of Ni(II) and Cu(II) beta-diketone complexes with thenoyltrifluoroacetone ligand. Spectrochim Acta A Mol Biomol Spectrosc. 2007;66:1024-9 pubmed
    Two kinds of nickel(II) and copper(II) beta-diketone complexes derived from thenoyltrifluoroacetone ligand with blue-violet light absorption were synthesized by reacting free ligand and different metal(II) ions in sodium methoxide ..
  31. Arnaud N, Georges J. Comprehensive study of the luminescent properties and lifetimes of Eu(3+) and Tb(3+) chelated with various ligands in aqueous solutions: influence of the synergic agent, the surfactant and the energy level of the ligand triplet. Spectrochim Acta A Mol Biomol Spectrosc. 2003;59:1829-40 pubmed
    ..The ligands used include model compounds such as thenoyltrifluoroacetone and pyridine-2,6-dicarboxylic acid and organic analytes of biological or pharmaceutical interest...
  32. Eto Y, Kang D, Hasegawa E, Takeshige K, Minakami S. Succinate-dependent lipid peroxidation and its prevention by reduced ubiquinone in beef heart submitochondrial particles. Arch Biochem Biophys. 1992;295:101-6 pubmed
    When succinate and ADP-Fe3+ chelate were added to beef heart submitochondrial particles pretreated with 2-thenoyltrifluoroacetone, an inhibitor of succinate dehydrogenase of the mitochondrial respiratory chain, the formation of ..
  33. Matsson M, Ackrell B, Cochran B, Hederstedt L. Carboxin resistance in Paracoccus denitrificans conferred by a mutation in the membrane-anchor domain of succinate:quinone reductase. Arch Microbiol. 1998;170:27-37 pubmed
    ..The apparent Km for quinone (DPB) and the sensitivity to thenoyltrifluoroacetone was normal for the carboxin-resistant enzyme, but the succinate:quinone reductase activity was lower than ..
  34. Yamagishi S, Edelstein D, Du X, Kaneda Y, Guzman M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001;276:25096-100 pubmed
    ..Rotenone, thenoyltrifluoroacetone (TTFA), carbonyl cyanide m-chlorophenylhydrazone (CCCP), Mn(III)tetrakis (4-benzoic acid) porphyrin (..
  35. Srinivasan S, Yeh M, Danziger E, Hatley M, Riggan A, Leitinger N, et al. Glucose regulates monocyte adhesion through endothelial production of interleukin-8. Circ Res. 2003;92:371-7 pubmed
    ..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs. ..
  36. Minato Y, Fassio S, HASE C. Malonate inhibits virulence gene expression in Vibrio cholerae. PLoS ONE. 2013;8:e63336 pubmed publisher
    ..Unlike another SDH inhibitor, 2-thenoyltrifluoroacetone (TTFA), which increased toxT transcription and slightly inhibited V...
  37. Nishikawa T, Edelstein D, Du X, Yamagishi S, Matsumura T, Kaneda Y, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-90 pubmed
    ..Normalizing levels of mitochondrial reactive oxygen species with each of these agents prevents glucose-induced activation of protein kinase C, formation of advanced glycation end-products, sorbitol accumulation and NFkappaB activation. ..
  38. Zhang J, Nicholls Grzemski F, Tirmenstein M, Fariss M. Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents. Chem Biol Interact. 2001;138:267-84 pubmed
    ..Surprisingly, TS did not protect hepatocytes against thenoyltrifluoroacetone (TTFA), a complex II inhibitor-induced enhancement of EMS-induced toxic oxidative damage...
  39. Zuo L, Pasniciuc S, Wright V, Merola A, Clanton T. Sources for superoxide release: lessons from blockade of electron transport, NADPH oxidase, and anion channels in diaphragm. Antioxid Redox Signal. 2003;5:667-75 pubmed
    ..rat diaphragm were inhibited at complex I (amobarbital or rotenone) or complex I and II (rotenone plus thenoyltrifluoroacetone). NADPH oxidases were blocked by diphenyliodonium. None of these treatments inhibited O2*- release...
  40. Lv Y, Zhang J, Cao W, Juan J, Zhang F, Xu Z. Enhanced luminescence of Eu(3+) by Y(3+) in ternary complexes Eu(X)Y(1-X)(TTA)3Dipy. Spectrochim Acta A Mol Biomol Spectrosc. 2007;68:382-6 pubmed
    Rare-earth ternary complexes Eu(X)Y(1-X)(TTA)3Dipy {X=0, 0.1, 0.25, 0.5, 0.75, 0.9, 1.0, using thenoyltrifluoroacetone (TTA) as ligand and 2,2'-dipyridyl (Dipy) as synergic agent} were synthesized...
  41. Paddenberg R, Goldenberg A, Faulhammer P, Braun Dullaeus R, Kummer W. Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature. Adv Exp Med Biol. 2003;536:163-9 pubmed
    ..Functional complex II is also necessary for hypoxic pulmonary vasoconstriction. ..
  42. Chen Y, McMillan Ward E, Kong J, Israels S, Gibson S. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci. 2007;120:4155-66 pubmed
    ..These results indicate that targeting mETC complex I and II selectively induces autophagic cell death through a ROS-mediated mechanism. ..
  43. Zhu X, Wang X, Jiang C. Spectrofluorimetric determination of 5-hydroxytryptamine using chlorosulphonylthenoyltrifluoroacetone-europium probe. Luminescence. 2007;22:487-92 pubmed
    ..0 x 10(-7)-1.2 x 10(-5) mol/L and 8.5 x 10(-8) mol/L, respectively. This method is simple, practical and relatively free of interference from coexisting substances, and can be applied to assess 5-HT in urine samples. ..
  44. Schweinzer E, Mao Y, Krajnik P, Getoff N, Goldenberg H. Reduction of extracellular dehydroascorbic acid by K562 cells. Cell Biochem Funct. 1996;14:27-31 pubmed
    ..At a concentration of DHA of 100 mu M this is 25 per cent of the observed reduction. ..
  45. Yang T, Zhang A, Honeggar M, Kohan D, Mizel D, Sanders K, et al. Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem. 2005;280:34966-73 pubmed
    ..treatment were completely blocked by any one of the mitochondrial inhibitors tested, such as rotenone, thenoyltrifluoroacetone, or carbonyl cyanide m-chlorophenylhydrazone, associated with remarkable inhibition of COX-2 expression...
  46. Armson A, Grubb W, Mendis A. The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae. Int J Parasitol. 1995;25:261-3 pubmed
    ..This strongly suggests that the S. ratti FR is functionally linked with the S. ratti ET-Complex I. 2-Thenoyltrifluoroacetone (TTFA, an inhibitor of ET-Complex II) inhibited FR (EC50 = 2.6 x 10(-5) M) and SDH (EC50 = 2...
  47. Huang T, Wan Y, Zhu Y, Fang X, Hiramatsu N, Hayakawa K, et al. Downregulation of gap junction expression and function by endoplasmic reticulum stress. J Cell Biochem. 2009;107:973-83 pubmed publisher
    ..Furthermore, induction of ER stress by hypoxic chemicals thenoyltrifluoroacetone and cobalt chloride was found to be associated with a reduction in Cx43...
  48. Cervera A, Bayley J, Devilee P, McCreath K. Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol Cancer. 2009;8:89 pubmed publisher
    ..These results support the notion that loss of mitochondrial function alters epigenetic processes and might provide a signature methylation mark for paraganglioma. ..
  49. Li J, Zeng H, Yu Q, Cao Y, Wen P. [Fluorescence spectra of the rare earth complex-PAA-g-PE films]. Guang Pu Xue Yu Guang Pu Fen Xi. 2001;21:40-2 pubmed
    ..certain pH value, the grafted films were made to react with the alcohol-water solution of Eu3+ and alpha-thenoyltrifluoroacetone (TTA) or with the chloroform-water solution of Tb3+ and acetyl actone (AcAc), thus causing the ..
  50. Maind S, Chattopadhyay N, Gandhi C, Kumar S, Sudersanan M. Quantitative evaluation of europium in blue ballpoint pen inks/offset printing inks tagged with europium thenoyltrifluoroacetonate by spectrofluorometry and ICP-AES. Sci Justice. 2008;48:61-6 pubmed
    ..The advantages and limitations of the tagging approach and proposed analytical techniques are discussed. ..
  51. Ikezawa N, Ifuku K, Endo T, Sato F. Inhibition of photosystem II of spinach by the respiration inhibitors piericidin A and thenoyltrifluoroacetone. Biosci Biotechnol Biochem. 2002;66:1925-9 pubmed
    ..Among the agents tested, piericidin A and thenoyltrifluoroacetone (TTFA) inhibited the photosynthetic electron transport of spinach as measured from chlorophyll (Chl) ..
  52. Karawajew L, Rhein P, Czerwony G, Ludwig W. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood. 2005;105:4767-75 pubmed
    ..of mitochondrial transmembrane potential (MTMP) by inhibitors of electron transport (rotenone, thenoyltrifluoroacetone (TTFA)) and adenosine triphosphate (ATP) synthesis (oligomycin) prevented stress-induced p53 protein ..
  53. Zhu X, Ge X, Jiang C. Spectrofluorimetric determination of dopamine using chlorosulfonylthenoyltrifluoroacetone-europium probe. J Fluoresc. 2007;17:655-61 pubmed
    ..2 x 10(-8) mol/l. This method is simple, practical and relatively free of interference from coexisting substances, and can be applied to assess DA in injection and human serum samples with good precision and accuracy. ..