schiff bases


Summary: Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. Singh A, Gupta V, Gupta B. Chromium(III) selective membrane sensors based on Schiff bases as chelating ionophores. Anal Chim Acta. 2007;585:171-8 pubmed
    The two chromium chelates of Schiff bases, N-(acetoacetanilide)-1,2-diaminoethane (L(1)) and N,N'-bis(acetoacetanilide)-triethylenetetraammine (L(2)), have been synthesized and explored as neutral ionophores for preparing poly(..
  2. Yao Y, Li Z. New insights into the mechanism of the Schiff base hydrolysis catalyzed by type I dehydroquinate dehydratase from S. enterica: a theoretical study. Org Biomol Chem. 2012;10:7037-44 pubmed publisher
    ..The new mechanistic insights obtained here will be valuable for the rational design of high-activity inhibitors of type I DHQD as non-toxic antimicrobials, anti-fungals, and herbicides...
  3. Joseph J, Nagashri K. Novel copper-based therapeutic agent for anti-inflammatory: synthesis, characterization, and biochemical activities of copper(II) complexes of hydroxyflavone Schiff bases. Appl Biochem Biotechnol. 2012;167:1446-58 pubmed publisher
    ..Superoxide dismutase and anti-inflammatory activities of the copper complexes have also been measured and discussed. ..
  4. Aboul Fadl T, Abdel Aziz H, Abdel Hamid M, Elsaman T, Thanassi J, Pucci M. Schiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase. Molecules. 2011;16:7864-79 pubmed publisher
    In the present study a series of Schiff bases of indoline-2,3-dione were synthesized and investigated for their Mtb gyrase inhibitory activity...
  5. Gwaram N, Ali H, Abdulla M, Buckle M, Sukumaran S, Chung L, et al. Synthesis, characterization, X-ray crystallography, acetyl cholinesterase inhibition and antioxidant activities of some novel ketone derivatives of gallic hydrazide-derived Schiff bases. Molecules. 2012;17:2408-27 pubmed publisher
    ..Some novel ketone derivatives of gallic hydrazide-derived Schiff bases were synthesized and examined for their antioxidant activities and in vitro and in silico acetyl cholinesterase ..
  6. Singh K, Kumar Y, Puri P, Kumar M, Sharma C. Cobalt, nickel, copper and zinc complexes with 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde Schiff bases: antimicrobial, spectroscopic, thermal and fluorescence studies. Eur J Med Chem. 2012;52:313-21 pubmed publisher
    Two new Schiff bases of 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde and 4-amino-5-mercapto-3-methyl/H-1,2,4-triazole [HL(1-2)] and their Cobalt, Nickel, Copper and Zinc complexes have been synthesized and characterized by elemental analyses,..
  7. Gwaram N, Ali H, Khaledi H, Abdulla M, Hadi A, Lin T, et al. Antibacterial evaluation of some Schiff bases derived from 2-acetylpyridine and their metal complexes. Molecules. 2012;17:5952-71 pubmed publisher
    A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies...
  8. Alam M, Choi J, Lee D. Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity. Bioorg Med Chem. 2012;20:4103-8 pubmed publisher
    ..Overall, 3f showed promising antioxidant and anti-inflammatory activities and may be used as the lead compound in a future study. ..
  9. Ibrahim M, Ali H, Abdullah M, Hassandarvish P. Acute toxicity and gastroprotective effect of the Schiff base ligand ¹H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats. Molecules. 2012;17:12449-59 pubmed publisher
    ..Research finding suggest that TNS and its nickel (II) complex could be considered as effective gastroprotective compounds. ..

More Information


  1. Singh A, Pandey O, Sengupta S. Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione. Spectrochim Acta A Mol Biomol Spectrosc. 2013;113:393-9 pubmed publisher
    Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2,3-dione...
  2. Qin W, Long S, Panunzio M, Biondi S. Schiff bases: a short survey on an evergreen chemistry tool. Molecules. 2013;18:12264-89 pubmed publisher outline on the synthesis and use of his most popular discovery: the imines, very well known and popular as Schiff Bases. Recent developments on their "metallo-imines" variants have been described...
  3. Duff B, Thangella V, Creaven B, Walsh M, Egan D. Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells. Eur J Pharmacol. 2012;689:45-55 pubmed publisher
    ..Results indicated that complexation of quinolinone Schiff bases with copper served to significantly enhance cytotoxicity...
  4. Anouar E, Raweh S, Bayach I, Taha M, Baharudin M, Di Meo F, et al. Antioxidant properties of phenolic Schiff bases: structure-activity relationship and mechanism of action. J Comput Aided Mol Des. 2013;27:951-64 pubmed publisher
    Phenolic Schiff bases are known for their diverse biological activities and ability to scavenge free radicals...
  5. Schaur R. Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Mol Aspects Med. 2003;24:149-59 pubmed
    ..Primary amines may alternatively react with the carbonyl group to form Schiff bases. Reactions which do not fit into this scheme are the oxidation and the reduction respective of the carbonyl ..
  6. Aboul Fadl T, Bin Jubair F, Aboul Wafa O. Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building. Eur J Med Chem. 2010;45:4578-86 pubmed publisher
    ..Thus, there is an urgent need for anti-TB drugs with enhanced activity against MDR strains. In recent years, Schiff bases of 1H-indole-2,3-diones are reported to exhibit anti-TB activity...
  7. Subramaniam S, Henderson R. Molecular mechanism of vectorial proton translocation by bacteriorhodopsin. Nature. 2000;406:653-7 pubmed publisher
    ..2 A in-plane and 3.6 A vertical) resolution, is largely localized to helices F and G, and provides an 'opening' of the protein to protons on the cytoplasmic side of the membrane...
  8. Gübbük I, Gup R, Ersoz M. Synthesis, characterization, and sorption properties of silica gel-immobilized Schiff base derivative. J Colloid Interface Sci. 2008;320:376-82 pubmed publisher
    ..Negative DeltaG values indicated that the sorption process for these three metal ions onto immobilized silica gel is spontaneous. ..
  9. Pandeya S, Sriram D, Nath G, Declercq E. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide. Eur J Pharm Sci. 1999;9:25-31 pubmed
    ..and 5-bromo derivatives have been reacted with N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and three ..
  10. Aquino A, Barbatti M, Lischka H. Excited-state properties and environmental effects for protonated schiff bases: a theoretical study. Chemphyschem. 2006;7:2089-96 pubmed
    ..CC2) methodologies have been used to study the ground state and excited states of protonated and neutral Schiff bases (PSB and SB) as models for the retinal chromophore...
  11. Kusnetzow A, Dukkipati A, Babu K, Ramos L, Knox B, Birge R. Vertebrate ultraviolet visual pigments: protonation of the retinylidene Schiff base and a counterion switch during photoactivation. Proc Natl Acad Sci U S A. 2004;101:941-6 pubmed
    ..The findings with MUV are in close analogy to rhodopsin and provides further support for the importance of the counterion switch in the photoactivation of both rod and cone visual pigments. ..
  12. Lanyi J. Bacteriorhodopsin. Annu Rev Physiol. 2004;66:665-88 pubmed
  13. Ritter E, Elgeti M, Hofmann K, Bartl F. Deactivation and proton transfer in light-induced metarhodopsin II/metarhodopsin III conversion: a time-resolved fourier transform infrared spectroscopic study. J Biol Chem. 2007;282:10720-30 pubmed
    ..We propose that the anti/syn conversion can only induce a fast reorientation and distance change of the Schiff base but fails to build up the full set of dark ground state constraints, presumably involving the Glu(134)/Arg(135) cluster. ..
  14. Palczewski K, Kumasaka T, Hori T, Behnke C, Motoshima H, Fox B, et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000;289:739-45 pubmed
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation. ..
  15. Szwergold B. Carnosine and anserine act as effective transglycating agents in decomposition of aldose-derived Schiff bases. Biochem Biophys Res Commun. 2005;336:36-41 pubmed
    ..k.a. Schiff bases) by nucleophilic attack of carnosine and/or anserine on the preformed aldosamine such as glucosyl-lysine...
  16. Okada A, Shibuguchi T, Ohshima T, Masu H, Yamaguchi K, Shibasaki M. Enantio- and diastereoselective catalytic Mannich-type reaction of a glycine schiff base using a chiral two-center phase-transfer catalyst. Angew Chem Int Ed Engl. 2005;44:4564-7 pubmed
  17. Verma M, Pandeya S, Singh K, Stables J. Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm. 2004;54:49-56 pubmed
    b>Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet)...
  18. Luecke H, Schobert B, Cartailler J, Richter H, Rosengarth A, Needleman R, et al. Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin. J Mol Biol. 2000;300:1237-55 pubmed publisher
    ..This accounts for the lowering of the pK(a) of Asp96, which then reprotonates the Schiff base via a newly formed chain of water molecules that is extending toward the Schiff base...
  19. Bondar A, Suhai S, Fischer S, Smith J, Elstner M. Suppression of the back proton-transfer from Asp85 to the retinal Schiff base in bacteriorhodopsin: a theoretical analysis of structural elements. J Struct Biol. 2007;157:454-69 pubmed
  20. Tian H, Guan R, Salsi E, Campanini B, Bettati S, Kumar V, et al. Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A. Biochemistry. 2010;49:6093-103 pubmed publisher
    ..Data suggest that interaction of intermediates with the substrate-binding loop and Q142 gives a properly aligned Michaelis complex and facilitates the beta-elimination reaction. ..
  21. Vogel R, Siebert F, Mathias G, Tavan P, Fan G, Sheves M. Deactivation of rhodopsin in the transition from the signaling state meta II to meta III involves a thermal isomerization of the retinal chromophore C[double bond]D. Biochemistry. 2003;42:9863-74 pubmed
    ..In the long term, Meta III decays likewise to opsin and free retinal by slow hydrolysis of the Schiff base. ..
  22. Kandori H. Hydration switch model for the proton transfer in the Schiff base region of bacteriorhodopsin. Biochim Biophys Acta. 2004;1658:72-9 pubmed
    ..This will have raised the pK(a) of the proton acceptor, and the proton transfer is from the Schiff base to Asp85. ..
  23. Raman N, Jeyamurugan R, Senthilkumar R, Rajkapoor B, Franzblau S. In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model. Eur J Med Chem. 2010;45:5438-51 pubmed publisher
    A new series of copper(II) and zinc(II) complexes have been designed and synthesized using a new type of Schiff bases derived from the reaction of 3-(3-phenyl-allylidene)-pentane-2,4-dione with para substituted aniline and benzene-1,2-..
  24. Szymczak J, Barbatti M, Lischka H. Is the photoinduced isomerization in retinal protonated Schiff bases a single- or double-torsional process?. J Phys Chem A. 2009;113:11907-18 pubmed publisher
  25. Vogel R, Fan G, Siebert F, Sheves M. Anions stabilize a metarhodopsin II-like photoproduct with a protonated Schiff base. Biochemistry. 2001;40:13342-52 pubmed
    ..This specificity correlates inversely with the strength of hydration of the respective anion species in solution and seems therefore to be determined mainly by its partitioning into the considerably less polar protein interior. ..
  26. Kumar K, Ganguly S, Veerasamy R, De Clercq E. Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones. Eur J Med Chem. 2010;45:5474-9 pubmed publisher
    ..Compound 2a showed better antiviral activity against the entire tested virus. ..
  27. Cheng L, Tang J, Luo H, Jin X, Dai F, Yang J, et al. Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases. Bioorg Med Chem Lett. 2010;20:2417-20 pubmed publisher
    Eight hydroxyl-substituted Schiff bases with the different number and position of hydroxyl group on the two asymmetric aromatic rings (A and B rings) were prepared by the reaction between the corresponding aromatic aldehyde and aniline...
  28. Chohan Z, Sumrra S, Youssoufi M, Hadda T. Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. Eur J Med Chem. 2010;45:2739-47 pubmed publisher
    A new series of oxovanadium(IV) complexes have been designed and synthesized with a new class of triazole Schiff bases derived from the reaction of 3,5-diamino-1,2,4-triazole with 2-hydroxy-1-naphthaldehyde, pyrrole-2-carboxaldehyde, ..
  29. Salga S, Ali H, Abdullah M, Abdelwahab S, Wai L, Buckle M, et al. Synthesis, characterization, acetylcholinesterase inhibition, molecular modeling and antioxidant activities of some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines. Molecules. 2011;16:9316-30 pubmed publisher
    Some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines were synthesized and characterized by mass spectroscopy, FTIR, UV-Visible, 1H and 13C-NMR...
  30. Chohan Z, Pervez H, Khan K, Rauf A, Maharvi G, Supuran C. Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins. J Enzyme Inhib Med Chem. 2004;19:85-90 pubmed
    ..The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active. ..
  31. Panneerselvam P, Nair R, Vijayalakshmi G, Subramanian E, Sridhar S. Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents. Eur J Med Chem. 2005;40:225-9 pubmed
    In the present study, a novel series of Schiff bases of 4-(4-aminophenyl)-morpholine were synthesised and characterised by IR, 1H-NMR, 13C-NMR, Mass spectral and elemental analysis...
  32. Garg B, Nandan Kumar D. Spectral studies of complexes of nickel(II) with tetradentate schiff bases having N2O2 donor groups. Spectrochim Acta A Mol Biomol Spectrosc. 2003;59:229-34 pubmed
    ..Kinetic and thermodynamic parameters were computed from the thermal decomposition data. The activation energy of either one step decomposition or two step decomposition of complexes lies 72-95 kJ mol(-1) range. ..
  33. Vogel R, Siebert F. Fourier transform IR spectroscopy study for new insights into molecular properties and activation mechanisms of visual pigment rhodopsin. Biopolymers. 2003;72:133-48 pubmed
  34. Chandra S, Kumar U. Spectral and magnetic studies on manganese(II), cobalt(II) and nickel(II) complexes with Schiff bases. Spectrochim Acta A Mol Biomol Spectrosc. 2005;61:219-24 pubmed
    ..Various physico-chemical techniques suggest an octahedral geometry for all the complexes. ..
  35. Light S, Minasov G, Shuvalova L, Duban M, Caffrey M, Anderson W, et al. Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. J Biol Chem. 2011;286:3531-9 pubmed publisher
    ..The structures and mechanistic insight presented here may inform the design of type I DHQD enzyme inhibitors...
  36. Mishra P, Rajak H, Mehta A. Synthesis of Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles and their evaluation for antimicrobial activities. J Gen Appl Microbiol. 2005;51:133-41 pubmed
    Twenty Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles have been synthesized with different aromatic aldehydes. The structures of the compounds were confirmed by nitrogen analysis, IR and 13C-NMR spectral data...
  37. Guo Z, Xing R, Liu S, Yu H, Wang P, Li C, et al. The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan. Bioorg Med Chem Lett. 2005;15:4600-3 pubmed
    Five kinds of Schiff bases of chitosan and carboxymethyl chitosan (CMCTS) have been prepared according to a previous method and the antioxidant activity was studied using an established system, such as superoxide and hydroxyl radical ..
  38. Jarrahpour A, Motamedifar M, Pakshir K, Hadi N, Zarei M. Synthesis of novel azo Schiff bases and their antibacterial and antifungal activities. Molecules. 2004;9:815-24 pubmed
    Ten new azo Schiff bases 5a-h and 7a-b were prepared in excellent yields via the condensation of different aromatic amines and a new azoaldehyde, 2-hydroxy-3- methoxy-5-(4-methoxyphenylazo)benzaldehyde (4) by two different methods...
  39. Karatepe M, Karatas F. Antioxidant, pro-oxidant effect of the thiosemicarbazone derivative Schiff base (4-(1-phenylmethylcyclobutane-3-yl)-2-(2-hydroxybenzylidenehydrazino) thiazole) and its metal complexes on rats. Cell Biochem Funct. 2006;24:547-54 pubmed
    ..In conclusion, the parameters measured show that Cu(L)2 caused considerable oxidative stress and Zn(L)2 behaved as an antioxidant. No oxidative stress in LH was observed compared to the control group. ..
  40. Zhang H, Syed S, Barbas C. Highly enantio- and diastereoselective Mannich reactions of glycine Schiff bases with in situ generated N-Boc-imines catalyzed by a cinchona alkaloid thiourea. Org Lett. 2010;12:708-11 pubmed publisher
    Highly enantio- and diastereoselective organocatalytic Mannich reactions of glycine Schiff bases with N-Boc-protected imines are described. Imines were generated in situ from bench-stable alpha-amido sulfones...
  41. Aggarwal N, Kumar R, Dureja P, Rawat D. Schiff bases as potential fungicides and nitrification inhibitors. J Agric Food Chem. 2009;57:8520-5 pubmed publisher
    A number of substituted Schiff bases were synthesized and characterized by (1)H NMR and mass spectrometry...
  42. Hearn M, Cynamon M, Chen M, Coppins R, Davis J, Joo On Kang H, et al. Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid. Eur J Med Chem. 2009;44:4169-78 pubmed publisher
  43. Lim Y, Wallace S, Bollinger J, Chen X, Lee D. Triferrocenes built on a C3-symmetric ligand platform: entry to redox-active pseudo-triphenylenes via chelation-driven stereoselection of triple Schiff bases. Inorg Chem. 2007;46:1694-703 pubmed
  44. Sineshchekov O, Sasaki J, Wang J, Spudich J. Attractant and repellent signaling conformers of sensory rhodopsin-transducer complexes. Biochemistry. 2010;49:6696-704 pubmed publisher
    ..have recently been distinguished experimentally by the opposite connection of their retinylidene protonated Schiff bases to the outwardly located periplasmic side and inwardly located cytoplasmic side...
  45. Ludeke S, Beck M, Yan E, Sakmar T, Siebert F, Vogel R. The role of Glu181 in the photoactivation of rhodopsin. J Mol Biol. 2005;353:345-56 pubmed
    ..A model for the specific role in coupling chromophore isomerization to protein conformational changes concomitant with receptor activation is presented. ..
  46. Virshup A, Punwong C, Pogorelov T, Lindquist B, Ko C, Martinez T. Photodynamics in complex environments: ab initio multiple spawning quantum mechanical/molecular mechanical dynamics. J Phys Chem B. 2009;113:3280-91 pubmed publisher
    ..Protein environments serve to direct the excited-state dynamics, leading to higher quantum yields and enhanced reaction selectivity. ..
  47. Schobert B, Brown L, Lanyi J. Crystallographic structures of the M and N intermediates of bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base. J Mol Biol. 2003;330:553-70 pubmed
    ..This suggests that the hydration of the cytoplasmic region we observe in N' might have occurred spontaneously, beginning at an existing water molecule as nucleus, in the cavities from residue rearrangements in the photocycle...
  48. Chohan Z, Farooq M, Scozzafava A, Supuran C. Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes. J Enzyme Inhib Med Chem. 2002;17:1-7 pubmed
    b>Schiff bases derived from oxaldiamide/oxalylhydrazine and pyrrol-2-carbaldehyde, or salicylaldehyde respectively, as well as their Zn(II) complexes have been prepared and tested as antibacterial agents...
  49. Luecke H, Schobert B, Richter H, Cartailler J, Lanyi J. Structure of bacteriorhodopsin at 1.55 A resolution. J Mol Biol. 1999;291:899-911 pubmed publisher
    ..A bilayer of 18 tightly bound lipid chains forms an annulus around the protein in the crystal. Contacts between the trimers in the membrane plane are mediated almost exclusively by lipids...
  50. Mahalingam M, Vogel R. The all-trans-15-syn-retinal chromophore of metarhodopsin III is a partial agonist and not an inverse agonist. Biochemistry. 2006;45:15624-32 pubmed
  51. Bayrak H, Demirbas A, Karaoglu S, Demirbas N. Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities. Eur J Med Chem. 2009;44:1057-66 pubmed publisher
    ..The antimicrobial activity study revealed that all the compounds screened showed good or moderate activity except compounds 3, 5c, 7, 9c, 9e, 9g, 9h, 11, and 13. ..
  52. Panneerselvam P, Rather B, Ravi Sankar Reddy D, Ramesh Kumar N. Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones. Eur J Med Chem. 2009;44:2328-33 pubmed publisher
    In the present study, a series of novel Schiff bases were synthesized by condensation of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones with different aromatic aldehydes via cyclized intermediate 6,8-dibromo-2-phenyl benzoxazin-4-one...
  53. Choi K, Lai V, Foster C, Morris A, Tolan D, Allen K. New superfamily members identified for Schiff-base enzymes based on verification of catalytically essential residues. Biochemistry. 2006;45:8546-55 pubmed
  54. Neutze R, Pebay Peyroula E, Edman K, Royant A, Navarro J, Landau E. Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport. Biochim Biophys Acta. 2002;1565:144-67 pubmed
  55. Lanyi J, Schobert B. Crystallographic structure of the retinal and the protein after deprotonation of the Schiff base: the switch in the bacteriorhodopsin photocycle. J Mol Biol. 2002;321:727-37 pubmed
  56. Kuz min V, Artemenko A, Lozytska R, Fedtchouk A, Lozitsky V, Muratov E, et al. Investigation of anticancer activity of macrocyclic Schiff bases by means of 4D-QSAR based on simplex representation of molecular structure. SAR QSAR Environ Res. 2005;16:219-30 pubmed
    ..990-0.861; cross-validation coefficient CVR=0.914-0.633). The molecular fragments increasing and decreasing anticancer activity were defined. This information may be useful for the design and direct synthesis of novel anticancer agents. ..
  57. Sakiyan I, Loğoğlu E, Arslan S, Sarı N, Sakiyan N. Antimicrobial activities of N-(2-hydroxy-1-naphthalidene)-amino acid(glycine, alanine, phenylalanine, histidine, tryptophane) Schiff bases and their manganese(III) complexes. Biometals. 2004;17:115-20 pubmed
    The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(..
  58. Benci S, Vaccari S, Mozzarelli A, Cook P. Time-resolved fluorescence of O-acetylserine sulfhydrylase. Biochim Biophys Acta. 1999;1429:317-30 pubmed
  59. Singh K, Singh D, Barwa M, Tyagi P, Mirza Y. Some bivalent metal complexes of Schiff bases containing N and S donor atoms. J Enzyme Inhib Med Chem. 2006;21:749-55 pubmed
    b>Schiff bases have been synthesized by the reaction of p-nitrobenzaldehyde, o-nitrobenzaldehyde and p-toluyaldehyde with 4-amino-5-mercapto-1,2,4-triazole...
  60. Waser M, Gratzer K, Herchl R, Muller N. Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts. Org Biomol Chem. 2012;10:251-4 pubmed publisher
    ..These compounds were found to catalyse the asymmetric ?-alkylation of glycine Schiff bases with high enantioselectivities and in good yields.
  61. Jezierska Mazzarello A, Panek J, Vuilleumier R, Koll A, Ciccotti G. Direct observation of the substitution effects on the hydrogen bridge dynamics in selected Schiff bases--a comparative molecular dynamics study. J Chem Phys. 2011;134:034308 pubmed publisher
    We have studied substituent effects on the properties of the intramolecular hydrogen bond of some ortho-hydroxy Schiff bases using density functional theory (DFT) based first-principle molecular dynamics (FPMD) and path integral molecular ..
  62. Kara D, Fisher A, Hill S. Determination of trace heavy metals in soil and sediments by atomic spectrometry following preconcentration with Schiff bases on Amberlite XAD-4. J Hazard Mater. 2009;165:1165-9 pubmed publisher
    ..The efficiency of the chelating resin and the accuracy of the proposed method were evaluated by the analysis of soil (SO-2) and sediment (LGC 6157 and MESS-3) certified reference materials. ..
  63. Jarrahpour A, Khalili D, De Clercq E, Salmi C, Brunel J. Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives. Molecules. 2007;12:1720-30 pubmed
    Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines...
  64. Ambike V, Adsule S, Ahmed F, Wang Z, Afrasiabi Z, Sinn E, et al. Copper conjugates of nimesulide Schiff bases targeting VEGF, COX and Bcl-2 in pancreatic cancer cells. J Inorg Biochem. 2007;101:1517-24 pubmed
    ..The mechanistic pathway for the biological activity involves inhibition of vascular endothelial growth factor (VEGF) and COX inhibition, as well as down regulation of antiapoptotic Bcl-2 and Bcl-(XL) proteins. ..
  65. Guiotto A, Ruzza P, Babizhayev M, Calderan A. Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs. Bioorg Med Chem. 2007;15:6158-63 pubmed
    ..The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress. ..
  66. Vogel R, Sakmar T, Sheves M, Siebert F. Coupling of protonation switches during rhodopsin activation. Photochem Photobiol. 2007;83:286-92 pubmed
  67. Chohan Z, Sumrra S. Synthesis, characterization and biological properties of thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes. J Enzyme Inhib Med Chem. 2012;27:187-93 pubmed publisher
    A new series of biologically active thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes have been synthesized and characterized on the basis of physical (m.p...
  68. Asiri A, Khan S. Synthesis and anti-bacterial activities of some novel Schiff bases derived from aminophenazone. Molecules. 2010;15:6850-8 pubmed publisher
    A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities...
  69. Röhrig U, Guidoni L, Laio A, Frank I, Rothlisberger U. A molecular spring for vision. J Am Chem Soc. 2004;126:15328-9 pubmed
    ..Hence, the initial step of vision can be understood as the compression of a molecular spring by a minor change of the nuclear coordinates. This spring can then release its strain by altering the protein environment. ..
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