isotretinoin

Summary

Summary: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.

Top Publications

  1. Malvasi A, Tinelli A, Buia A, De Luca G. Possible long-term teratogenic effect of isotretinoin in pregnancy. Eur Rev Med Pharmacol Sci. 2009;13:393-6 pubmed
    The isotretinoin, a 13-cis-retinoic acid, has revolutionized the management of severe treatment-resistant acne and it has been widely used for a range of dermatological conditions, in 90% of the time in young women between 13 and 45 years ..
  2. Gemmeke A, Wollina U. Folliculitis decalvans of the scalp: response to triple therapy with isotretinoin, clindamycin, and prednisolone. Acta Dermatovenerol Alp Pannonica Adriat. 2006;15:184-6 pubmed
    ..We report on a 27-year-old man with folliculitis decalvans successfully treated with a combination of isotretinoin, corticosteroids, and clindamycin.
  3. Tirado Sanchez A, León Dorantes G. [Erectile dysfunction during isotretinoin therapy]. Actas Urol Esp. 2005;29:974-6 pubmed
    b>Isotretinoin is a very effective drug for the treatment of severe recalcitrant acne. However, it's use is associated with many side effects, sometimes is associated with the emergence of psychiatric symptoms...
  4. Spada C, Riccioni M, Marchese M, Familiari P, Costamagna G. Isotretinoin-associated pan-enteritis. J Clin Gastroenterol. 2008;42:923-5 pubmed publisher
    ..Because of nodular acne, the patient had been treated with Isotretinoin, a 13-cis-retinoic acid (20-mg twice daily, for 15 d)...
  5. Teichert M, Visser L, Dufour M, Rodenburg E, Straus S, De Smet P, et al. Isotretinoin use and compliance with the Dutch Pregnancy Prevention Programme: a retrospective cohort study in females of reproductive age using pharmacy dispensing data. Drug Saf. 2010;33:315-26 pubmed publisher
    b>Isotretinoin is very effective in the treatment of severe acne...
  6. Ferguson S, Cisneros F, Hanig J, Berry K. Oral treatment with ACCUTANE does not increase measures of anhedonia or depression in rats. Neurotoxicol Teratol. 2007;29:642-51 pubmed
    ..A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459.]...
  7. Chang Y, Hu D, Wu W. Effect of oral 13-cis-retinoic acid treatment on postoperative clinical outcome of eyes with proliferative vitreoretinopathy. Am J Ophthalmol. 2008;146:440-446 pubmed publisher
    ..To determine whether postoperative oral 13-cis-retinoic acid (RA) treatment could improve the outcome of vitreoretinal surgery with silicone oil for the management of proliferative vitreoretinopathy (PVR)...
  8. Eksioglu E, Oztekin F, Unlu E, Cakci A, Keyik B, Karadavut I. Sacroiliitis and polyneuropathy during isotretinoin treatment. Clin Exp Dermatol. 2008;33:122-4 pubmed
    b>Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system...
  9. Ishikawa J, Sutoh C, Ishikawa A, Kagechika H, Hirano H, Nakamura S. 13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat. Eur J Neurosci. 2008;27:2363-72 pubmed publisher
    ..Moreover, RXR has a greater influence on the morphology of 5-HT neurons than RAR. The receptor-mediated actions of 13-cis-RA presented here may provide a clue for further research on depression associated with the use of 13-cis-RA. ..

More Information

Publications70

  1. Schaefer C, Meister R, Weber Schoendorfer C. Isotretinoin exposure and pregnancy outcome: an observational study of the Berlin Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy. Arch Gynecol Obstet. 2010;281:221-7 pubmed publisher
    Apart from thalidomide, retinoids like isotretinoin are the strongest teratogens in humans known today. The overall risk of birth defects is estimated as up to 30% after exposure during embryogenesis...
  2. Veal G, Errington J, Rowbotham S, Illingworth N, Malik G, Cole M, et al. Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma. Clin Cancer Res. 2013;19:469-79 pubmed publisher
    ..Body weight-based dosing should not be implemented for children less than 12 kg and pharmacologic data support higher doses for children unable to swallow 13-cisRA capsules. ..
  3. Dhir R, Gehi N, Agarwal R, More Y. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. Indian J Dermatol Venereol Leprol. 2008;74:187 pubmed
    Due to the late introduction of oral isotretinoin, there is only a single report of the use of this drug from India...
  4. Petersen B, Bygum A. Erosive pustular dermatosis of the scalp: a case treated successfully with isotretinoin. Acta Derm Venereol. 2008;88:300-1 pubmed publisher
  5. Karadag A, Ertugrul D, Tutal E, Akin K. Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?. Br J Dermatol. 2010;162:798-802 pubmed publisher
    b>Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment...
  6. Wang F, Kwak H, Elbuluk N, Kaczmarek A, Hamilton T, Voorhees J, et al. Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne. J Am Acad Dermatol. 2009;61:252-8 pubmed publisher
    ..The CYP26 enzyme acts specifically on tRA, but not 13-cis RA (isotretinoin), a retinoid used to treat severe acne...
  7. Bernstein C, Nugent Z, Longobardi T, Blanchard J. Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol. 2009;104:2774-8 pubmed publisher
    There is anecdotal evidence that isotretinoin use is associated with development of colitis. We aimed at determining whether there is an association between isotretinoin use and development of inflammatory bowel disease (IBD)...
  8. Bozdağ K, Gulseren S, Guven F, Cam B. Evaluation of depressive symptoms in acne patients treated with isotretinoin. J Dermatolog Treat. 2009;20:293-6 pubmed publisher
    There have been concerns about the association between isotretinoin therapy and depressive symptoms. The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression...
  9. Bagatin E, Parada M, Miot H, Hassun K, Michalany N, Talarico S. A randomized and controlled trial about the use of oral isotretinoin for photoaging. Int J Dermatol. 2010;49:207-14 pubmed publisher
    Topical retinoids are used to treat photoaging; oral isotretinoin is gold standard for acne; "off label" indications, including photoaging, have been reported with insufficient evidence of efficacy...
  10. Raza K, Singh B, Singla S, Wadhwa S, Garg B, Chhibber S, et al. Nanocolloidal carriers of isotretinoin: antimicrobial activity against Propionibacterium acnes and dermatokinetic modeling. Mol Pharm. 2013;10:1958-63 pubmed publisher
    Acne, a common skin disease in teenagers, is caused by Propionibacterium acnes (P. acnes). Isotretinoin (ITR) is though reported to have immense antiacne potential, yet there are hardly any reports vouching its antimicrobial activity...
  11. Marron S, Tomas Aragones L, Boira S. Anxiety, depression, quality of life and patient satisfaction in acne patients treated with oral isotretinoin. Acta Derm Venereol. 2013;93:701-6 pubmed publisher
    Oral isotretinoin is effective in the clinical control of acne, but the relationship between this treatment and its psychosocial impact on the patient has not been completely clarified...
  12. Manders K, de Vries L, Roumen F. [Pregnancy after isotretinoin use]. Ned Tijdschr Geneeskd. 2013;157:A6567 pubmed
    Acne is a common problem that is increasingly being effectively treated with isotretinoin, a highly teratogenic agent...
  13. Tinoco M, Tamler C, Maciel G, Soares D, Avelleira J, Azulay D. Pyoderma gangrenosum following isotretinoin therapy for acne nodulocystic. Int J Dermatol. 2008;47:953-6 pubmed publisher
    A 19-year-old man with nodulocystic acne on baseline was treated with isotretinoin therapy. After 1 month on the medication, he developed pyoderma gangrenosum on his pubis area, arms and legs, and pathergy on a puncture site...
  14. Pereira M, Roncada E, Oliveira C, Monteiro R, Abreu M, Ortigosa L. Acne fulminans and isotretinoin: case report. An Bras Dermatol. 2011;86:983-5 pubmed
    ..It can be induced by isotretinoin and some authors believe that the occurrence of this condition is dose dependent...
  15. Bremner J, Shearer K, McCaffery P. Retinoic acid and affective disorders: the evidence for an association. J Clin Psychiatry. 2012;73:37-50 pubmed publisher
    b>Isotretinoin (13-cis-retinoic acid), approved by the US Food and Drug Administration for the treatment of acne, carries a black box warning related to the risk of depression, suicide, and psychosis...
  16. De D, Kanwar A. Combination of low-dose isotretinoin and pulsed oral azithromycin in the management of moderate to severe acne: a preliminary open-label, prospective, non-comparative, single-centre study. Clin Drug Investig. 2011;31:599-604 pubmed publisher
    The conventionally used dose of isotretinoin in acne causes significant dose-related adverse effects. Low-dose isotretinoin has been used successfully in mild to moderate papulopustular acne...
  17. Halvorsen J, Stern R, Dalgard F, Thoresen M, Bjertness E, Lien L. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol. 2011;131:363-70 pubmed publisher
    ..Adverse events including suicidal ideation and depression that have been associated with therapies for acne may reflect the burden of substantial acne rather than the effects of medication. ..
  18. Crijns I, Straus S, Luteijn M, Gispen de Wied C, Raine J, de Jong van den Berg L. Implementation of the harmonized EU isotretinoin Pregnancy Prevention Programme: a questionnaire survey among European regulatory agencies. Drug Saf. 2012;35:27-32 pubmed publisher
    There is little information on the status of the implementation of the isotretinoin Pregnancy Prevention Programme (PPP) in the EU, and on compliance with this programme by the regulatory agencies...
  19. Gilbert M, Gonzalez J, Hunter K, Hess K, Giglio P, Chang E, et al. A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro Oncol. 2010;12:1167-72 pubmed publisher
    ..alone (150 mg/m²/day, 7/14-day schedule) or with doublet combinations of thalidomide (400 mg/day), isotretinoin (100 mg/m²/day), and/or celecoxib (400 mg twice daily), or all 3 agents. Toxicity was assessed after 4 weeks...
  20. Zanelato T, Gontijo G, Alves C, Pinto J, Cunha P. Disabling acne fulminans. An Bras Dermatol. 2011;86:S9-12 pubmed
    ..Use of isotretinoin, testosterone, and exacerbated immune responses in the body are related triggers...
  21. Liu Y, Kagechika H, Ishikawa J, Hirano H, Matsukuma S, Tanaka K, et al. Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. J Neurochem. 2008;106:1104-16 pubmed publisher
  22. Dopheide M, Morgan R. Isotretinoin (13-cis-retinoic acid) alters learning and memory, but not anxiety-like behavior, in the adult rat. Pharmacol Biochem Behav. 2008;91:243-51 pubmed publisher
    b>Isotretinoin (ISO, 13-cis-retinoic acid) is commonly prescribed as Accutane for the treatment of acne. ISO is a known teratogen and the physical side effects of the drug have been well documented...
  23. O Reilly K, Trent S, Bailey S, Lane M. 13-cis-Retinoic acid alters intracellular serotonin, increases 5-HT1A receptor, and serotonin reuptake transporter levels in vitro. Exp Biol Med (Maywood). 2007;232:1195-203 pubmed
    ..Accutane (13-cis-retinoic acid, isotretinoin) treatment has been reported to increase depression in humans...
  24. O Reilly K, Shumake J, Bailey S, Gonzalez Lima F, Lane M. Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice. Eur J Pharmacol. 2009;605:68-77 pubmed publisher
  25. Rozin A, Kagna O, Shiller Y. Sacroiliitis and severe disability due to isotretinoin therapy. Rheumatol Int. 2010;30:985-6 pubmed publisher
    We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and ..
  26. Aydogan K, Turan O, Onart S, Yazici B, Karadogan S, Tokgoz N. Neurological and neurophysiological effects of oral isotretinoin: a prospective investigation using auditory and visual evoked potentials. Eur J Dermatol. 2008;18:642-6 pubmed publisher
    ..The purpose of the present study was to investigate whether oral isotretinoin can affect brainstem and cortical sensorial activities...
  27. Berard A, Azoulay L, Nakhai Pour H, Moussally K. Isotretinoin and the risk of cardiovascular, cerebrovascular and thromboembolic disorders. Dermatology. 2011;223:45-51 pubmed publisher
    Case reports suggest that isotretinoin use is associated with an increased risk of cardiovascular disorders; however, the clinical significance has not been determined...
  28. Liu A, Yang D, Gerhardstein P, Hsu S. Relapse of acne following isotretinoin treatment: a retrospective study of 405 patients. J Drugs Dermatol. 2008;7:963-6 pubmed
    b>Isotretinoin is the most effective systemic treatment option for patients with nodulocystic acne or acne vulgaris who have failed a treatment with systemic antibiotics...
  29. Melnik B. The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. G Ital Dermatol Venereol. 2010;145:559-71 pubmed
    It is the purpose of this review to demonstrate that oral isotretinoin treatment restores all major pathogenetic factors of acne vulgaris by upregulation of the nuclear transcription factor FoxO1, which will be shown to be the major ..
  30. Sardana K, Garg V, Sehgal V, Mahajan S, Bhushan P. Efficacy of fixed low-dose isotretinoin (20 mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris. J Eur Acad Dermatol Venereol. 2009;23:556-60 pubmed publisher
    In view of the potentially serious side-effects of standard isotretinoin (0.5-1...
  31. Gorpelioglu C, Ozol D, Sarifakioglu E. Influence of isotretinoin on nasal mucociliary clearance and lung function in patients with acne vulgaris. Int J Dermatol. 2010;49:87-90 pubmed publisher
    ..We evaluated the effect of 13-cis-retinoic acid (isotretinoin) on nasal mucociliary clearance and pulmonary function tests (PFTs) in patients with severe acne vulgaris...
  32. Stobaugh D, Deepak P, Ehrenpreis E. Alleged isotretinoin-associated inflammatory bowel disease: disproportionate reporting by attorneys to the Food and Drug Administration Adverse Event Reporting System. J Am Acad Dermatol. 2013;69:393-8 pubmed publisher
    Some studies have purported to link isotretinoin prescribed for acne with the development of inflammatory bowel disease (IBD)...
  33. Kwinter J, Dekoven J. Generalized eruptive histiocytoma treated with isotretinoin. J Cutan Med Surg. 2009;13:146-50 pubmed
    ..We report for the first time the use of isotretinoin in the treatment of GEH...
  34. Marqueling A, Zane L. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review. Semin Cutan Med Surg. 2007;26:210-20 pubmed publisher
    b>Isotretinoin (13-cis retinoic acid) is an effective treatment for severe cystic or recalcitrant acne vulgaris; however, concerns have been raised regarding its potential association with depression and suicidal behavior...
  35. Hahm B, Min S, Yoon M, Shin Y, Kim J, Jung J, et al. Changes of psychiatric parameters and their relationships by oral isotretinoin in acne patients. J Dermatol. 2009;36:255-61 pubmed publisher
    Oral isotretinoin is a highly effective agent for the treatment of moderate to severe acne, but ever since oral isotretinoin was introduced as a modality for acne, the relationship between oral isotretinoin therapy and psychiatric ..
  36. Rehn L, Meririnne E, Hook Nikanne J, Isometsa E, Henriksson M. Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. J Eur Acad Dermatol Venereol. 2009;23:1294-7 pubmed publisher
    To investigate the putative association between isotretinoin treatment and depressive symptoms or suicidal ideation among Finnish male military conscripts...
  37. Shin J, Cheetham T, Wong L, Niu F, Kass E, Yoshinaga M, et al. The impact of the iPLEDGE program on isotretinoin fetal exposure in an integrated health care system. J Am Acad Dermatol. 2011;65:1117-25 pubmed publisher
    Preventing fetal exposure to isotretinoin is widely acknowledged as an important safety issue...
  38. Nelson A, Cong Z, Gilliland K, Thiboutot D. TRAIL contributes to the apoptotic effect of 13-cis retinoic acid in human sebaceous gland cells. Br J Dermatol. 2011;165:526-33 pubmed publisher
    The full mechanism of action of isotretinoin [13-cis retinoic acid (13-cis RA)] in treating acne is unknown...
  39. Lumsden K, Nelson A, Dispenza M, Gilliland K, Cong Z, Zaenglein A, et al. Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne. Br J Dermatol. 2011;165:302-10 pubmed publisher
    A clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. Lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area...
  40. McGrath E, Lovell C, Gillison F, Darvay A, Hickey J, Skevington S. A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms. Br J Dermatol. 2010;163:1323-9 pubmed
    b>Isotretinoin is an efficacious treatment for acne, but has been controversially linked with depression. This study aimed to examine the effects of isotretinoin on quality of life(QoL) and depression using a prospective design...
  41. Bidoli P, Cortinovis D, Colombo I, Crippa A, Cicchiello F, Villa F, et al. Isotretinoin plus clindamycin seem highly effective against severe erlotinib-induced skin rash in advanced non-small cell lung cancer. J Thorac Oncol. 2010;5:1662-3 pubmed publisher
    ..No effective treatment for the rash is available. We carried out a preliminary investigation on isotretinoin and clindamycin. Among 56 advanced lung cancer patients treated with erlotinib, 31 (53%) developed rash...
  42. Cumurcu T, Sezer E, Kilic R, Bulut Y. Comparison of dose-related ocular side effects during systemic isotretinoin administration. Eur J Ophthalmol. 2009;19:196-200 pubmed
    To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications.
  43. Karadag A, Tutal E, Ertugrul D, Akin K. Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study. Int J Dermatol. 2011;50:1564-9 pubmed publisher
    b>Isotretinoin (Iso) has been used for the treatment of acne. Some previous studies reported elevated homocysteine (Hcy) levels after treatment with Iso...
  44. Vezzoli P, Marzano A, Onida F, Alessi E, Galassi B, Tomirotti M, et al. Cetuximab-induced acneiform eruption and the response to isotretinoin. Acta Derm Venereol. 2008;88:84-6 pubmed publisher
  45. Schmitt J, Tavares M, Cerci F. Adult women with acne have a higher risk of elevated triglyceride levels with the use of oral isotretinoin. An Bras Dermatol. 2011;86:807-10 pubmed
    There are restrictions associated with the use of isotretinoin because of its effects on the lipid profile...
  46. Azoulay L, Oraichi D, Berard A. Isotretinoin therapy and the incidence of acne relapse: a nested case-control study. Br J Dermatol. 2007;157:1240-8 pubmed
    Previous studies on predictors of acne relapse in patients treated with isotretinoin had either small sample sizes, short follow-up periods, or lacked population-based data...
  47. Raza K, Singh B, Singla N, Negi P, Singal P, Katare O. Nano-lipoidal carriers of isotretinoin with anti-aging potential: formulation, characterization and biochemical evaluation. J Drug Target. 2013;21:435-42 pubmed publisher
    Treatment of photoaging includes non-prescription cosmeceuticals and prescription products, retinoids. Isotretinoin, an established anti-acne retinoid, is also reported to delay the aging process...
  48. Bremner J, McCaffery P. The neurobiology of retinoic acid in affective disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:315-31 pubmed
    ..of retinoic acid in the CNS has focused on the developing brain, in part stimulated by the observation that isotretinoin (13-cis retinoic acid), an isomer of retinoic acid used in the treatment of acne, is highly teratogenic for the ..
  49. Tsai P, Huang C, Lee C, Li C, Huang Y, Tsai Y, et al. Isotretinoin oil-based capsule formulation optimization. ScientificWorldJournal. 2013;2013:856967 pubmed publisher
    The purpose of this study was to develop and optimize an isotretinoin oil-based capsule with specific dissolution pattern. A three-factor-constrained mixture design was used to prepare the systemic model formulations...
  50. Crijns H, Straus S, Gispen de Wied C, de Jong van den Berg L. Compliance with pregnancy prevention programmes of isotretinoin in Europe: a systematic review. Br J Dermatol. 2011;164:238-44 pubmed publisher
    Most of the publications on isotretinoin, pregnancy and compliance with the pregnancy prevention programme (PPP) originate from North America. Information specific for the European situation is very limited...
  51. Autret Leca E, Kreft Jais C, Elefant E, Cissoko H, Darrouzain F, Grimaldi Bensouda L, et al. Isotretinoin exposure during pregnancy: assessment of spontaneous reports in France. Drug Saf. 2010;33:659-65 pubmed publisher
    In three previous studies, we have shown that pregnant women were still being exposed to isotretinoin and that compliance with recommendations was incomplete...
  52. Azoulay L, Blais L, Koren G, Lelorier J, Berard A. Isotretinoin and the risk of depression in patients with acne vulgaris: a case-crossover study. J Clin Psychiatry. 2008;69:526-32 pubmed
    To determine whether isotretinoin increases the risk of depression in patients with acne vulgaris. A case-crossover study was performed among subjects who received > or = 1 isotretinoin prescription from 1984 through 2003...
  53. Grønhøj Larsen F, Jakobsen P, Grønhøj Larsen C, Heidenheim M, Held E, Nielsen Kudsk F. The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. Br J Dermatol. 2009;161:664-70 pubmed publisher
    b>Isotretinoin is effective in the treatment of severe acne and rosacea. Both parent drug and its main metabolite 4-oxo-isotretinoin are potentially teratogenic compounds and contain a carboxylic acid moiety...
  54. Georgala S, Korfitis C, Ioannidou D, Alestas T, Kylafis G, Georgala C. Dissecting cellulitis of the scalp treated with rifampicin and isotretinoin: case reports. Cutis. 2008;82:195-8 pubmed
    ..We report 4 cases of dissecting cellulitis of the scalp successfully treated with oral rifampicin and oral isotretinoin. To our knowledge, this is the first report of oral rifampicin used concomitantly with oral isotretinoin in ..
  55. Matthay K, Reynolds C, Seeger R, Shimada H, Adkins E, Haas Kogan D, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol. 2009;27:1007-13 pubmed publisher
  56. Bachmann C, Grabarkiewicz J, Theisen F, Remschmidt H. Isotretinoin, depression and suicide ideation in an adolescent boy. Pharmacopsychiatry. 2007;40:128 pubmed
  57. Dispenza M, Wolpert E, Gilliland K, Dai J, Cong Z, Nelson A, et al. Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients. J Invest Dermatol. 2012;132:2198-205 pubmed publisher
    ..b>Isotretinoin is a pro-drug for all-trans retinoic acid, which can induce long-term remissions of acne; however, its complete ..
  58. Crijns H, van Rein N, Gispen de Wied C, Straus S, de Jong van den Berg L. Prescriptive contraceptive use among isotretinoin users in the Netherlands in comparison with non-users: a drug utilisation study. Pharmacoepidemiol Drug Saf. 2012;21:1060-6 pubmed publisher
    To assess the compliance with the isotretinoin Pregnancy Prevention Programme (PPP) by evaluating the use of prescribed contraceptives among isotretinoin users...
  59. Sundström A, Alfredsson L, Sjölin Forsberg G, Gerdén B, Bergman U, Jokinen J. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ. 2010;341:c5812 pubmed publisher
    To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne...
  60. Ertugrul D, Karadag A, Tutal E, Akin K. Isotretinoin does not induce insulin resistance in patients with acne. Clin Exp Dermatol. 2011;36:124-8 pubmed publisher
    b>Isotretinoin treatment causes hypertriglyceridaemia. Insulin resistance is also associated with hypertriglyceridaemia. It is not known if isotretinoin is related to insulin resistance...
  61. Soria A, Canoui Poitrine F, Wolkenstein P, Poli F, Gabison G, Pouget F, et al. Absence of efficacy of oral isotretinoin in hidradenitis suppurativa: a retrospective study based on patients' outcome assessment. Dermatology. 2009;218:134-5 pubmed publisher
    In analogy to acne, oral isotretinoin has been considered in the treatment of hidradenitis suppurativa (HS). To assess the efficacy of oral isotretinoin according to patients...