trifluoroacetic acid


Summary: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.

Top Publications

  1. Suchocki P, Jakoniuk D, Fitak B. Specific spectrophotometric method with trifluoroacetic acid for the determination of selenium(IV) in selenitetriglycerides. J Pharm Biomed Anal. 2003;32:1029-36 pubmed
    ..We stated that selenitetriglycerides react quantitatively with trifluoroacetic acid (TFA) in dichloromethane giving a red-coloured conjugate...
  2. Arrieta Baez D, Stark R. Using trifluoroacetic acid to augment studies of potato suberin molecular structure. J Agric Food Chem. 2006;54:9636-41 pubmed
    Systematically varied reaction times and concentrations of trifluoroacetic acid (TFA) have been used to remove polysaccharides associated with suberin isolated from potato wound periderm, thereby augmenting spectroscopic determinations of ..
  3. Zhou B, Li Y, Gillespie J, He G, Horsley R, Schwarz P. Doehlert matrix design for optimization of the determination of bound deoxynivalenol in barley grain with trifluoroacetic acid (TFA). J Agric Food Chem. 2007;55:10141-9 pubmed
    ..of this study was to optimize a method for determination of nonextractable DON in barley grain using trifluoroacetic acid (TFA)...
  4. Zhou B, He G, Schwarz P. Occurrence of bound deoxynivalenol in Fusarium head blight-infected barley (Hordeum vulgare L.) and malt as determined by solvolysis with trifluoroacetic acid. J Food Prot. 2008;71:1266-9 pubmed
    ..detection after standard acetonitrile:water extraction, while total DON was determined using treatment with trifluoroacetic acid. Bound DON is the difference between the total and free values...
  5. Pauff S, Miller S. A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore. J Org Chem. 2013;78:711-6 pubmed publisher
    ..we report a sulfonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroacetic acid (TFA)...
  6. Han J, Kim N, Kim E. Trifluoroacetic acid activates ATP-sensitive K(+) channels in rabbit ventricular myocytes. Biochem Biophys Res Commun. 2001;285:1136-42 pubmed
    ..reported here used a patch-clamp technique to test the hypothesis that a metabolite of isoflurane, trifluoroacetic acid (TFA), contributes to isoflurane-induced cardioprotection via K(ATP) channel activation...
  7. Apffel A, Fischer S, Goldberg G, Goodley P, Kuhlmann F. Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases. J Chromatogr A. 1995;712:177-90 pubmed
    ..the sensitivity of peptide mapping with electrospray liquid chromatography--mass spectrometry using trifluoroacetic acid (TFA) containing HPLC mobile phases...
  8. Gaussier H, Morency H, Lavoie M, Subirade M. Replacement of trifluoroacetic acid with HCl in the hydrophobic purification steps of pediocin PA-1: a structural effect. Appl Environ Microbiol. 2002;68:4803-8 pubmed
    b>Trifluoroacetic acid (TFA) is a purification contaminant associated with pediocin PA-1 that interferes with Fourier transform infrared spectroscopy structural analysis...
  9. Sázelová P, Kašička V, Solínová V, Koval D. Determination of purity degree and counter-ion content in lecirelin by capillary zone electrophoresis and capillary isotachophoresis. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;841:145-51 pubmed
    ..Concentrations of contaminating counter-ions, the anions of trifluoromethanesulfonic acid (TFMSA), trifluoroacetic acid (TFA) and acetic acid (AcOH), were determined by CITP analyses in anionic mode with LE 10 mM HCl/His, pH 6...

More Information

Publications111 found, 100 shown here

  1. Lasch P, Nattermann H, Erhard M, Stämmler M, Grunow R, Bannert N, et al. MALDI-TOF mass spectrometry compatible inactivation method for highly pathogenic microbial cells and spores. Anal Chem. 2008;80:2026-34 pubmed publisher
    ..Among several physical, chemical, and mechanical inactivation procedures, inactivation by trifluoroacetic acid (TFA) proved to be the best method in terms of bactericidal capacity and information content of the mass ..
  2. Jerz G, Wybraniec S, Gebers N, Winterhalter P. Target-guided separation of Bougainvillea glabra betacyanins by direct coupling of preparative ion-pair high-speed countercurrent chromatography and electrospray ionization mass-spectrometry. J Chromatogr A. 2010;1217:4544-54 pubmed publisher
    ..2:2:1:5 (v/v/v/v) was used with addition of ion-pair forming reagent trifluoroacetic acid. The preparative HSCCC-eluate had to be modified by post-column addition of a make-up solvent stream ..
  3. Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, et al. Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand. Nucl Med Biol. 2017;46:50-53 pubmed publisher
    ..reacted with [11C]MeI, using DMF as the solvent and NaH as base, followed by deprotection with trifluoroacetic acid/water mixture, resulting in enantiomerically pure carbon-11 radioligand, [11C]THK-5351 - (S)-1-..
  4. Huang Z, Wang Y, Qiu M, Sun L, Liao J, Wang R, et al. Effect of T-2 toxin-injected shrimp muscle extracts on mouse macrophage cells (RAW264.7). Drug Chem Toxicol. 2018;41:16-21 pubmed publisher
    ..The effect of toxic shrimp muscle subjected to different processing conditions (high pressure, trifluoroacetic acid, acid and alkali digestions, artificial digestive juice [to simulate exposure to gastric and intestinal ..
  5. Lee C, Lin C, Lee J, Chiu C, Lu W, Wu M. Synthesis of carbazoles via an intramolecular cyclization of 2-(6-substituted 3(Z)-hexen-1,5-diynyl)anilines and their related molecules. J Org Chem. 2004;69:2106-10 pubmed
    ..Subsequent cyclizations of acetamide analogues 10a-g gave carbazoles 2a-g in 53-86% yields. ..
  6. Song Z, Xie B, Ma H, Zhang R, Li P, Liu L, et al. Modified HPLC-ESI-MS Method for Glycated Hemoglobin Quantification Based on the IFCC Reference Measurement Procedure and Its Application for Quantitative Analyses in Clinical Laboratories of China. J Clin Lab Anal. 2016;30:457-63 pubmed publisher
    ..1% (26.5 mmol/l) formic acid instead of trifluoroacetic acid. Moreover, in order to minimize matrix interference and reduce the running time, a solid-phase extraction ..
  7. Frison G, Frasson S, Zancanaro F, Tedeschi G, Zamengo L. Detection of 3-methylmethcathinone and its metabolites 3-methylephedrine and 3-methylnorephedrine in pubic hair samples by liquid chromatography-high resolution/high accuracy Orbitrap mass spectrometry. Forensic Sci Int. 2016;265:131-7 pubmed publisher
    ..after the addition of the internal standard 3,4-methylenedioxypropylamphetamine, extracted with methanol:trifluoroacetic acid 9:1 at 45°C for one night...
  8. Chen T, Yeung Y. Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid. Org Biomol Chem. 2016;14:4571-5 pubmed publisher
    A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed. The resulting 3,4-dihydroisocoumarines are valuable building blocks in organic synthesis.
  9. Le Saux G, Ciampi S, Gaus K, Gooding J. Electrochemical behavior of gold colloidal alkyl modified silicon surfaces. ACS Appl Mater Interfaces. 2009;1:2477-83 pubmed publisher
    ..Cyclic voltammetry showed that the enhancement of electron transfer to the silicon surface by the presence of nanoparticles is influenced by the number of tethered nanoparticles. ..
  10. Zhang C, Luo H, Wu Y, Zhang J, Zhang F, Lin G, et al. Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1011:45-52 pubmed publisher
    ..1mm) with isocratic elution using methanol containing 0.003% ammonium acetate (w/v) and 0.003% trifluoroacetic acid (v/v) at a flow of 0.3mL/min...
  11. Aoki K, Obata T, Yamazaki Y, Mori Y, Hirokawa H, Koseki J, et al. Potent platelet-derived growth factor-beta receptor (PDGF-betaR) inhibitors: Synthesis and structure-activity relationships of 7-[3-(cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one derivatives. Chem Pharm Bull (Tokyo). 2007;55:255-67 pubmed
    ..We found that trifluoroacetic acid (TFA)-catalyzed coupling of pyrrolo[2,3-b]pyridines with quinoxalin-2-ones proceeded efficiently under mild ..
  12. Takamuku T, Kyoshoin Y, Noguchi H, Kusano S, Yamaguchi T. Liquid structure of acetic acid-water and trifluoroacetic acid-water mixtures studied by large-angle X-ray scattering and NMR. J Phys Chem B. 2007;111:9270-80 pubmed
    The structures of acetic acid (AA), trifluoroacetic acid (TFA), and their aqueous mixtures over the entire range of acid mole fraction xA have been investigated by using large-angle X-ray scattering (LAXS) and NMR techniques...
  13. Zheng W, Park J, Abd El Aty A, Kim S, Cho S, Choi J, et al. Development and validation of a simple solid-phase extraction method coupled with liquid chromatography-triple quadrupole tandem mass spectrometry for simultaneous determination of lincomycin, tylosin A, and tylosin B in royal jelly. Biomed Chromatogr. 2017;: pubmed publisher
    ..For extraction and purification, we employ 1% trifluoroacetic acid and 0.1 M Na2 EDTA solutions along with an Oasis HLB cartridge...
  14. Stathopoulos P, Papas S, Tsikaris V. C-terminal N-alkylated peptide amides resulting from the linker decomposition of the Rink amide resin: a new cleavage mixture prevents their formation. J Pept Sci. 2006;12:227-32 pubmed
    ..Oxidized by-product in the tested Cys- and Met-containing peptides were not observed, even if thiols were not used in the cleavage mixture. ..
  15. García Ruano J, Torrente E, Alonso I, Rodriguez M, Martín Castro A, Degl Innocenti A, et al. Synthesis of enantiomerically pure anti-1,2-diaryl and syn-1,2-alkylaryl vic-selenoamines. J Org Chem. 2012;77:1974-82 pubmed publisher
    ..They are easily transformed into enantiomerically pure (1R,2S)-1-aryl[or (1S,2S)-1-alkyl]-2-(phenylseleno)-2-phenylethylamines by reaction with t-BuLi and subsequent methanolysis of the generated sulfinamide derivatives with TFA. ..
  16. Boullerne A, Polak P, Braun D, Sharp A, Pelligrino D, Feinstein D. Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis. J Neurochem. 2014;129:696-703 pubmed publisher
    ..These findings underscore the fact that a knowledge of peptide fraction is as critical as knowledge of peptide purity when using peptides from different sources. ..
  17. Lamiel Garcia O, Fernandez Hevia D, Caballero A, Illas F. Adsorption properties of trifluoroacetic acid on anatase (101) and (001) surfaces: a density functional theory study. Phys Chem Chem Phys. 2015;17:23627-33 pubmed publisher
    The interaction of trifluoroacetic acid with anatase TiO2(101) and TiO2(001) surfaces has been studied by means of periodic density functional theory based calculations...
  18. Pulici M, Quartieri F, Felder E. Trifluoroacetic anhydride-mediated solid-phase version of the Robinson-Gabriel synthesis of oxazoles. J Comb Chem. 2005;7:463-73 pubmed
    ..In addition, we disclose a novel variant of the Ugi four-component reaction that allows for the preparation of compounds 2 in a single synthetic step...
  19. Stovbun S, Skoblin A, Zanin A, Mikhailov A, Tverdislov V, Bragina E, et al. Metric similarity of dynamic commutation processes in situ and in vitro. Bull Exp Biol Med. 2012;153:843-5 pubmed
    ..Applications of these phenomena to in vivo cell commutation were discussed. ..
  20. Siderhurst M, Park S, Buller C, Jamie I, Manoukis N, Jang E, et al. Raspberry Ketone Trifluoroacetate, a New Attractant for the Queensland Fruit Fly, Bactrocera Tryoni (Froggatt). J Chem Ecol. 2016;42:156-62 pubmed publisher
    ..RKTA shows good potential as a new lure for improved surveillance and control of Q-fly. ..
  21. Shi X, Qiu Y, Yu H, Liu C, Yuan Y, Yin P, et al. Increasing the anticancer performance of bufalin (BUF) by introducing an endosome-escaping polymer and tumor-targeting peptide in the design of a polymeric prodrug. Colloids Surf B Biointerfaces. 2018;166:224-234 pubmed publisher
    ..After hydrolysis by trifluoroacetic acid and post-functionalization the final polymeric prodrug, P(OEGMA-co-BUF-co-RGD)-g-P(DEA-co-BMA), was ..
  22. Hernandez D, Mose R, Skrydstrup T. Reductive lithiation of methyl substituted diarylmethylsilanes: application to silanediol peptide precursors. Org Lett. 2011;13:732-5 pubmed publisher
    ..The replacement of the currently used diphenylsilane motif by a more labile diarylsilane moiety allows the selective hydrolysis of one or two aryl groups by treatment with TFA. ..
  23. Yang B, Kong E, Xue X, Zhao S, Lin S. [Qualitative and quantitative analysis of fluoxetine hydrochloride by 19F NMR]. Yao Xue Xue Bao. 2012;47:630-3 pubmed
    ..Long capillary tube containing trifluoroacetic acid was used as internal standard for the integration measurements and straight line was obtained with good ..
  24. Kim J, Tran T, Hong S, Jeong J. A reference measurement procedure for amino acids in blood using isotope dilution ultra-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1055-1056:72-80 pubmed publisher
    ..1% v/v trifluoroacetic acid. The limit of detection range of this method was 2-52fmol, and the RSDs of accuracy and precision from ..
  25. Wang X, Graveland Bikker J, de Kruif C, Robillard G. Oligomerization of hydrophobin SC3 in solution: from soluble state to self-assembly. Protein Sci. 2004;13:810-21 pubmed
    ..This value is similar to the critical concentration for SC3 self-assembly. Therefore, dimeric SC3 is indicated to be the building block for both aggregation in solution and self-assembly at hydrophobic/hydrophilic interfaces. ..
  26. Forsdahl G, Gmeiner G. Investigation of the silylation of ephedrines using N-methyl-N-trimethylsilyl-trifluoroacetamide. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;811:201-8 pubmed
    ..An evaluation of various silylation conditions compatible with screening methods in doping control analysis is presented. The method was found to be well suited for quantification of ephedrines in doping control...
  27. Brooks P. Electron transfer collisions with oriented trifluoroacetic acid (CF3CO2H). J Phys Chem A. 2009;113:14296-301 pubmed publisher
    Electron transfer collisions between neutral K atoms and neutral, oriented trifluoroacetic acid molecules, CF(3)CO(2)H, are studied in crossed molecular beams at center of mass energies from 6 to 18 eV...
  28. Giannetti L, Giorgi A, Necci F, Ferretti G, Buiarelli F, Neri B. Validation study on avermectine residues in foodstuffs. Anal Chim Acta. 2011;700:11-5 pubmed publisher
    ..0 to 200.0 ?g kg(-1). The main advantages of the presented method are its rapidity, the specificity, the good precision and recovery that make it very suitable to the detection and determination of avermectines...
  29. Kulikov A, Zinchenko A. Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations. J Pharm Biomed Anal. 2007;43:983-8 pubmed
    ..The method employs the Vydac Proteins C4 column with a mobile phase of aqueous solution of trifluoroacetic acid and UV detection at 206 nm. A linear response (r>0.9999) was observed in the range of 13...
  30. Bucak S, Cenker C, Nasir I, Olsson U, Zackrisson M. Peptide nanotube nematic phase. Langmuir. 2009;25:4262-5 pubmed publisher
    ..Because the peptides carry a positive charge, the nanotubes are charge-stabilized. Because of the very large aspect ratio, the tubes form an ordered phase that presumably is nematic. ..
  31. Kinoshita H, Ingham O, Ong W, Beeler A, Porco J. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. J Am Chem Soc. 2010;132:6412-8 pubmed publisher
    ..A number of tandem processes leading to novel chemotypes including aza-Prins/intramolecular Friedel-Crafts annulations have been identified, and both reaction scope and mechanism further investigated. ..
  32. Falconer I, Mant C, McKnight C, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017;1521:44-52 pubmed publisher
    ..Additionally, we report on the sensitivity of this elution behavior to the concentration of the additive trifluoroacetic acid in the mobile phase and present optimized conditions for separating HP36 from the full fusion protein by ..
  33. Song D, Chen Y, Wang R, Liu C, Jiang H, Luo G. Crossed-aldol condensation of cycloalkanones with aromatic aldehydes catalyzed by copper(II) trifluoroacetate. Prep Biochem Biotechnol. 2009;39:201-7 pubmed publisher
    ..The reaction proceeded smoothly in good to excellent yields. ..
  34. Xie J, Zhao J, Hu D, Duan J, Tang Y, Li S. Comparison of polysaccharides from two species of Ganoderma. Molecules. 2012;17:740-52 pubmed publisher
    ..HPTLC profiles of their TFA hydrolysates colored with different reagents and their monosaccharides composition were also similar. ..
  35. Huang D, Liu Y, Peng S, Liu S. Dinickel complexes with anthyridine-based ligands. Dalton Trans. 2016;45:8265-71 pubmed publisher
    ..Complexation of Ni(OAc)2 with and in trifluoroacetic acid provided the corresponding dinickel complexes [{Ni2()(H2O)6(CF3COO)2}(CF3COO)2] () and [Ni2()(CF3COO)4(H2O)]..
  36. Jamali S, Mousavi N, Bagherzadeh M, Kia R, Samouei H. Stimuli-responsive emissive behavior of 1- and 1,3-connectivities in azulene-based imine ligands: cycloplatination and Pt-Tl dative bond formation. Dalton Trans. 2017;46:11327-11334 pubmed publisher
    ..emissive behavior and their fluorescence can be switched on and off by protonation and neutralization with trifluoroacetic acid and trimethylamine, respectively...
  37. Royer A, Laporte F, Bouchonnet S, Communal P. Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide. J Chromatogr A. 2006;1108:129-35 pubmed
    ..The method, therefore, was shown to allow accurate determination of ethephon residues in drinking and surface water with a limit of quantification of 0.1 microg/L. ..
  38. Zhao L, Zou J, Wang X, Yan C, Gao R, Liu M, et al. [Separation of proteins by gradient pressurized capillary electrochromatography]. Se Pu. 2005;23:669-72 pubmed and the effects of applied voltage, stationary phase and concentration of ion-pairing agent (trifluoroacetic acid, TFA) on the gradient p-CEC were also studied...
  39. Du Y, Liu R, Linn G, Zhao K. Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization. Org Lett. 2006;8:5919-22 pubmed
    ..Other novel pyrrole-fused aromatic compounds can also be achieved by this method. ..
  40. Kurosu M, Biswas K, Crick D. Polymer-supported (2,6-dichloro- 4-alkoxyphenyl)(2,4-dichlorophenyl)methanol: a new linker for solid-phase organic synthesis. Org Lett. 2007;9:1141-4 pubmed
    ..However, the HTPM linkers can conveniently be cleaved by the solvolytic displacement reactions with 20% TFA. [structure: see text] ..
  41. Zhu K, Gu B, Kerry M, Mintert M, Luong J, Pursch M. Elimination of N,O-bis(trimethylsilyl)trifluoroacetamide interference by base treatment in derivatization gas chromatography mass spectrometry determination of parts per billion of alcohols in a food additive. J Chromatogr A. 2017;1490:74-79 pubmed publisher
    ..In contrast, aqueous sodium hydroxide decomposed BSTFA into trifluoroacetic acid, which went entirely into the aqueous layer...
  42. Pallotta A, Philippe V, Boudier A, Leroy P, Clarot I. Highly sensitive and simple liquid chromatography assay with ion-pairing extraction and visible detection for quantification of gold from nanoparticles. Talanta. 2018;179:307-311 pubmed publisher
    ..6mm, 3µm) column and with a mobile phase containing acetonitrile and 0.1% trifluoroacetic acid aqueous solution (25/75, V/V) at 1.0mLmin-1.and at a wavelength of 555nm...
  43. Hamada T, Tanaka H, Izumine H, Ohira M. Evaluation of an embedded polar C4 phase for hydrophobic protein analysis by reversed-phase liquid chromatography. J Chromatogr A. 2004;1043:27-32 pubmed
    ..Polar groups were embedded on this phase. And this column was evaluated with low concentration of trifluoroacetic acid (TFA) and formic acid...
  44. Sena L, Matos H, Dórea H, Pimentel M, de Santana D, de Santana F. Dispersive liquid-liquid microextraction based on solidification of floating organic drop and high-performance liquid chromatography to the analysis of cocaine's major adulterants in human urine. Toxicology. 2017;376:102-112 pubmed publisher
    ..6mm; 5?m; 80Å) in gradient elution mode using acetonitrile-trifluoroacetic acid 0.026% (v,v) (pH=2.5) at 1mLmin-1 as mobile phase, at 25°C, and detection at 235nm...
  45. Llamas Saiz A, Grotenbreg G, Overhand M, van Raaij M. Double-stranded helical twisted beta-sheet channels in crystals of gramicidin S grown in the presence of trifluoroacetic and hydrochloric acids. Acta Crystallogr D Biol Crystallogr. 2007;63:401-7 pubmed
    ..Synthetically obtained gramicidin S was crystallized from a solution containing water, methanol, trifluoroacetic acid and hydrochloric acid. The structure was solved and refined at 0.95 A resolution...
  46. Ema M, Naya M, Yoshida K, Nagaosa R. Reproductive and developmental toxicity of degradation products of refrigerants in experimental animals. Reprod Toxicol. 2010;29:1-9 pubmed publisher
    ..on the reproductive and developmental toxicity of the degradation products of refrigerants, including trifluoroacetic acid (TFA), carbon dioxide (CO(2)), carbon monoxide (CO), carbonyl fluoride (CF), hydrogen fluoride (HF) and ..
  47. Chen D, Han X, Du Y, Wang H, Xu P. In Situ Raman Monitoring of Silver(I)-Aided Laser-Driven Cleavage Reaction of Cyclobutane. Chemphyschem. 2016;17:46-50 pubmed publisher
    ..This work may open up a new avenue for studying cyclobutane cleavage reactions, as compared to the conventional routes using ex situ techniques. ..
  48. Wang E, Nagarajan Y, Carroll F, Schug K. Reversed-phase separation parameters for intact proteins using liquid chromatography with triple quadrupole mass spectrometry. J Sep Sci. 2016;39:3716-3727 pubmed publisher
    ..Chromatographic parameters including the concentration of trifluoroacetic acid, flow rate, gradient slope, temperature, mobile phase composition, and stationary phase chemistry were ..
  49. Fischer D, Geyer A, Loos E. Occurrence of glucosylsucrose [alpha-D-glucopyranosyl- (1-->2)-alpha-D-glucopyranosyl-(1-->2)-beta-D-fructofuranoside] and glucosylated homologues in cyanobacteria. Structural properties, cellular contents and possible function as thermoprotect. FEBS J. 2006;273:137-49 pubmed
    ..The results are discussed including previous reports on cyanobacterial oligosaccharides and with respect to possible functions of these compounds in the living cell...
  50. Karki S, Fábián L, Friscic T, Jones W. Powder X-ray diffraction as an emerging method to structurally characterize organic solids. Org Lett. 2007;9:3133-6 pubmed
    ..We illustrate such use of powder diffraction using two case studies of molecular cocrystals of trifluoroacetic acid and malonic acid, involving theobromine, a model active pharmaceutical ingredient...
  51. Diopan V, Adam V, Havel L, Kizek R. Phytohormones as important biologically active molecules--their simple simultaneous detection. Molecules. 2009;14:1825-39 pubmed publisher
    ..The determined content of alpha-naphthalene acetic acid was in good agreement with that declared by the manufacturer...
  52. Merten C, Li H, Nafie L. Simultaneous resonance Raman optical activity involving two electronic states. J Phys Chem A. 2012;116:7329-36 pubmed publisher
    ..Based on measured UV-vis electronic absorbance spectra and corresponding TD-DFT calculations, the most likely two states associated with the RROA spectra are identified...
  53. Naeem A, Akram M, Khan R. Conformational states of trifluoroacetic acid-treated cytochrome c in the presence of salts and alcohols. Protein J. 2004;23:185-95 pubmed
    ..carried out a systematic investigation of salts- and alcohols-induced conformational alterations on the trifluoroacetic acid (TFA)-treated ferricytochrome c by soret absorption spectroscopy, far UV circular dichroism (CD), ..
  54. Hassan S, Titchener Hooker N, Willoughby N. Determining particle density distribution of expanded bed adsorbents. Biotechnol Bioeng. 2005;92:659-63 pubmed
    ..This result confirms experimentally that an assumption of a single constant mean density for EBA particles is acceptable for hydrodynamic modelling and performance prediction purposes...
  55. Frolov A, Hoffmann R. Separation of Amadori peptides from their unmodified analogs by ion-pairing RP-HPLC with heptafluorobutyric acid as ion-pair reagent. Anal Bioanal Chem. 2008;392:1209-14 pubmed publisher
    ..Here, we compare aqueous acetonitrile and methanol gradients containing either trifluoroacetic acid (TFA) or heptafluorobutyric acid (HFBA) as ion-pairing agents to separate such peptide pairs...
  56. Lestard M, Tuttolomondo M, Wann D, Robertson H, Rankin D, Ben Altabef A. A conformational and vibrational study of CF(3)COSCH(2)CH(3). J Chem Phys. 2009;131:214303 pubmed publisher
    ..Using calculated frequencies as a guide, evidence for both C(s) and C(1) structures is obtained in the IR spectra. Harmonic vibrational frequencies and scaled force fields have been calculated for both conformers...
  57. Reid J, Holmes D, Mason D, Shah B, Borchers C. Towards the development of an immuno MALDI (iMALDI) mass spectrometry assay for the diagnosis of hypertension. J Am Soc Mass Spectrom. 2010;21:1680-6 pubmed publisher
    ..984. MS/MS sequence confirmation provides absolute specificity. The iMALDI angiotensin I assay, therefore, has the potential to be developed into a method for determining PRA that has advantages in time, in specificity, and in safety...
  58. Diekmann J, Adams K, Klunder G, Evans L, Steele P, Vogt C, et al. Portable microcoil NMR detection coupled to capillary electrophoresis. Anal Chem. 2011;83:1328-35 pubmed publisher
    ..An LOD of 31.8 nmol for perfluorotributylamine with a resolution of 4 ppm has been achieved with this system...
  59. Sardela V, Sardela P, Pereira H, Aquino Neto F. Consequences of the formation of 3,4-dimethyl-5-phenyl-1,3-oxazolidine on the analysis of ephedrines in urine by gas chromatography and a new method for confirmation as N-trifluoroacetyl-O-t-butyldimethylsilyl ether derivatives. J Chromatogr A. 2011;1218:1266-72 pubmed publisher
    ..These N-TFA-O-TBDMS derivatives lead to an increase in the number and mass of diagnostic ions, meet the identification criteria, and provide an improvement in chromatographic resolution, allowing the separation of the ephedrines...
  60. Henne S, Shallcross D, Reimann S, Xiao P, Brunner D, O Doherty S, et al. Future emissions and atmospheric fate of HFC-1234yf from mobile air conditioners in Europe. Environ Sci Technol. 2012;46:1650-8 pubmed publisher
    ..will be released into the atmosphere, where it is almost completely transformed to the persistent trifluoroacetic acid (TFA)...
  61. Davies S, Fletcher A, Lee J, Lorkin T, Roberts P, Thomson J. Asymmetric synthesis of (-)-martinellic acid. Org Lett. 2013;15:2050-3 pubmed publisher
  62. Miyazaki K, Tsugita A. C-terminal sequencing method for peptides and proteins by the reaction with a vapor of perfluoric acid in acetic anhydride. Proteomics. 2004;4:11-9 pubmed
  63. Metselaar G, Cornelissen J, Rowan A, Nolte R. Acid-initiated stereospecific polymerization of isocyanopeptides. Angew Chem Int Ed Engl. 2005;44:1990-3 pubmed
  64. Tseng Y, Liu C, Kuo F, Shieh M. Solid-phase column chromatographic and gas chromatographic-mass spectrometric determination of heptaminol in human urine and related pharmacokinetic profiles. J Anal Toxicol. 2006;30:365-9 pubmed
    ..The unchanged parent compound was completely eliminated in urine within 24 h and an average of approximately 97% of the dose was excreted through the renal pathway...
  65. Guthery B, Bassindale A, Pillinger C, Morgan G. The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2009;23:340-8 pubmed publisher
    ..6 and 5.4 ng/mL (flunitrazepam); 2.5 and 8.5 ng/mL (7-amino-FN), respectively. There is scope to extend this protocol to screen a large number of drugs and metabolites stored in a library database...
  66. Angelini G, De Maria P, Chiappe C, Fontana A, Pierini M, Siani G. Basicity of pyridine and some substituted pyridines in ionic liquids. J Org Chem. 2010;75:3912-5 pubmed publisher
    ..constants for ion pair formation of some pyridines have been evaluated by spectrophotometric titration with trifluoroacetic acid in different ionic liquids. The basicity order is the same in ionic liquids and in water...
  67. Valenti L, Paci M, De Pauli C, Giacomelli C. Infrared study of trifluoroacetic acid unpurified synthetic peptides in aqueous solution: trifluoroacetic acid removal and band assignment. Anal Biochem. 2011;410:118-23 pubmed publisher
    Synthetic peptide or protein samples are mostly unpurified with trifluoroacetic acid (TFA) used during the synthesis procedure, which strongly interferes with structure determination by infrared (IR) spectroscopy...
  68. Righi M, Bedini A, Piersanti G, Romagnoli F, Spadoni G. Direct, one-pot reductive alkylation of anilines with functionalized acetals mediated by triethylsilane and TFA. Straightforward route for unsymmetrically substituted ethylenediamine. J Org Chem. 2011;76:704-7 pubmed publisher
    ..This new procedure offers significant advantages over previous synthetic approaches, including brevity, mild reaction conditions, excellent yields, and high functional group tolerance...
  69. Renner R. Natural oceanic source for fluorinated tracer. Environ Sci Technol. 2005;39:357A-358A pubmed
  70. Dohi T, Minamitsuji Y, Maruyama A, Hirose S, Kita Y. A new H2O2/acid anhydride system for the iodoarene-catalyzed C-C bond-forming reactions of phenols. Org Lett. 2008;10:3559-62 pubmed publisher
    ..The catalytic system supplies a wide range of substrates and functional availabilities sufficient to be used in the key synthetic process of producing biologically important Amaryllidaceae alkaloids...
  71. Rasimick B, Nekich M, Hladek M, Musikant B, Deutsch A. Interaction between chlorhexidine digluconate and EDTA. J Endod. 2008;34:1521-3 pubmed publisher
    ..The precipitate was produced and redissolved in a known amount of dilute trifluoroacetic acid. The amount of chlorhexidine and EDTA present in the dissolved precipitate was determined by reverse-phase ..
  72. Nakamura K, Kanao T, Uesugi T, Hara T, Sato T, Kawakami T, et al. Synthesis of peptide thioesters via an N-S acyl shift reaction under mild acidic conditions on an N-4,5-dimethoxy-2-mercaptobenzyl auxiliary group. J Pept Sci. 2009;15:731-7 pubmed publisher
    ..The utility was demonstrated by the synthesis of a 41-mer peptide thioester, a phosphorylated peptide thioester and a 33-mer peptide thioester containing a trimethylated lysine residue...
  73. Ouyang Q, Zhu Y, Zhang C, Yan K, Li Y, Zheng J. An efficient PIFA-mediated synthesis of fused diporphyrin and triply-singly interlacedly linked porphyrin array. Org Lett. 2009;11:5266-9 pubmed publisher
    ..This reaction showed high selectivity for Zn(II) porphyrins and had been successfully applied in the synthesis of a novel triply-singly interlacedly linked porphyrin array with lower energy gap...
  74. Lien S, Kvitvang H, Bruheim P. Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites. J Chromatogr A. 2012;1247:118-24 pubmed publisher
    ..The developed method is thus a valuable contribution to the field of absolute quantitative metabolomics...
  75. Chen G, Li W, Zhang C, Zhou C, Feng S. Preparation of a novel hyperbranched carbosilane-silica hybrid coating for trace amount detection by solid phase microextraction/gas chromatography. J Chromatogr A. 2012;1256:213-21 pubmed publisher
    ..b>Trifluoroacetic acid, as a catalyst in this process, helps produce a homogeneous hybrid coating layer...
  76. Dohi T, Kita Y. Hypervalent Iodine-Induced Oxidative Couplings (New Metal-Free Coupling Advances and Their Applications in Natural Product Syntheses). Top Curr Chem. 2016;373:1-23 pubmed publisher
    ..Under such considerations, this chapter focuses on the oxidative coupling reactions of hypervalent iodine reagents found in total syntheses of biologically active natural products and their related compounds. ..
  77. Liu G, Sieburth S. Enantioselective alpha-silyl amino acid synthesis by reverse-aza-Brook rearrangement. Org Lett. 2003;5:4677-9 pubmed
    ..Standard coupling protocols, including the use of trifluoroacetic acid for removal of the Boc group, yield a tripeptide with a central silane amino acid.
  78. Hua F, Kita R, Wegner G, Meyer W. Interactions between brushlike polyacrylic acid side chains on a polyacrylate backbone in dioxane-water. Chemphyschem. 2005;6:336-43 pubmed
    ..The two d-PAAs were obtained by hydrolyzing d-P(tert-BA)s in the presence of trifluoroacetic acid (TFA)...
  79. Manyanga V, Grishina O, Yun Z, Hoogmartens J, Adams E. Comparison of liquid chromatographic methods with direct detection for the analysis of gentamicin. J Pharm Biomed Anal. 2007;45:257-62 pubmed
    ..a company method was checked by using a Gemini column and a mobile phase containing an aqueous solution of trifluoroacetic acid (TFA) and pentafluoropropionic acid (PFPA) adjusted to pH 2.6 with sodium hydroxide (NaOH)...
  80. Seveno M, Voxeur A, Rihouey C, Wu A, Ishii T, Chevalier C, et al. Structural characterisation of the pectic polysaccharide rhamnogalacturonan II using an acidic fingerprinting methodology. Planta. 2009;230:947-57 pubmed publisher
    ..This methodology was developed using RG-II fractions isolated from citrus pectins and then validated for RG-II isolated from the Arabidopsis mur1 mutant and irx10 irx10-like double mutant...
  81. Hasehira K, Miyanishi N, Sumiyoshi W, Hirabayashi J, Nakakita S. Development of a chemical strategy to produce rare aldohexoses from ketohexoses using 2-aminopyridine. Carbohydr Res. 2011;346:2693-8 pubmed publisher
    ..Although Gul and Ido represent the most unstable aldohexoses, our method provides a practical way to rapidly obtain these rare aldohexoses as needed...
  82. Yuan Y, Yang R, Zhang Negrerie D, Wang J, Du Y, Zhao K. One-pot synthesis of 3-hydroxyquinolin-2(1H)-ones from N-phenylacetoacetamide via PhI(OCOCF3)2-mediated ?-hydroxylation and H2SO4-promoted intramolecular cyclization. J Org Chem. 2013;78:5385-92 pubmed publisher
    ..The hydroxyl group in the generated ?-hydroxylated intermediate can be well tolerated in the second H2SO4-promoted cyclization step...
  83. Seo C, Shin H. HPLC-PDA Method for Simultaneous Determination of Nine Marker Components in Banhasasim-Tang. J Chromatogr Sci. 2016;54:299-304 pubmed publisher
    ..1% (v/v) trifluoroacetic acid in distilled water (A) and acetonitrile (B) as mobile phases. The flow rate was 1...
  84. Kobayashi J, Nakamura M, Mori Y, Yamashita Y, Kobayashi S. Catalytic enantio- and diastereoselective aldol reactions of glycine-derived silicon enolate with aldehydes: an efficient approach to the asymmetric synthesis of anti-beta-hydroxy-alpha-amino acid derivatives. J Am Chem Soc. 2004;126:9192-3 pubmed
    ..The resulting N-trifluoroacetyl group is easily cleaved under either acidic or basic conditions and can be used directly as a protecting group for further transformations...
  85. Shou W, Naidong W. Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;825:186-92 pubmed
    b>Trifluoroacetic acid (TFA) is a commonly used additive in HPLC and LC-MS analysis of basic compounds...
  86. Wood P, Khan M, Moskal J. Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;831:313-9 pubmed
  87. Raj S, Kumar G, Raghavalu T, Kumar P, Mohan R, Jayavel R. Structural, spectral, linear and nonlinear optical properties of new nonlinear optical L-histidinium trichloroacetate crystals. Spectrochim Acta A Mol Biomol Spectrosc. 2006;65:1021-4 pubmed
    ..These preliminary results suggest that LHTCA crystal can act as a potential and promising candidate for frequency doubling applications even from the near UV region to the near IR...
  88. Boyer J, Vetrone F, Cuccia L, Capobianco J. Synthesis of colloidal upconverting NaYF4 nanocrystals doped with Er3+, Yb3+ and Tm3+, Yb3+ via thermal decomposition of lanthanide trifluoroacetate precursors. J Am Chem Soc. 2006;128:7444-5 pubmed
  89. Crankshaw M, Grant G. Modification of cysteine. Curr Protoc Protein Sci. 2001;Chapter 15:Unit15.1 pubmed publisher
    ..Gentle oxidation of cysteine residues to disulfides by exposure to air is detailed. Support protocols are included for recrystallization of iodoacetic acid, colorimetric detection of free sulfhydryls, and desalting of modified samples...
  90. Luecken D, L Waterland R, Papasavva S, Taddonio K, Hutzell W, Rugh J, et al. Ozone and TFA impacts in North America from degradation of 2,3,3,3-Tetrafluoropropene (HFO-1234yf), a potential greenhouse gas replacement. Environ Sci Technol. 2010;44:343-8 pubmed publisher
    ..Atmospheric decomposition of HFO-1234yf produces trifluoroacetic acid (TFA), which is subject to wet and dry deposition...
  91. Kitagawa S, Noji A, Matsushita N, Nakagawa H, Asai T, Ohitani H. Large-volume sample on-line concentration of angiotensins in non-aqueous capillary electrophoresis. Electrophoresis. 2011;32:1480-5 pubmed publisher
    ..When the sample solution (ACN containing 0.5% trifluoroacetic acid and angiotensins) was injected as a large-volume plug, the analytes were concentrated at the inlet end of ..
  92. Kajimoto T, Morimoto K, Ogawa R, Dohi T, Kita Y. Glycosylation Reaction of Thioglycosides by Using Hypervalent Iodine(III) Reagent as an Excellent Promoter. Chem Pharm Bull (Tokyo). 2016;64:838-44 pubmed publisher
    ..We report now that the hypervalent iodine effectively induced glycosylation reaction of thioglycosides with various alcohols. This method features a high efficiency, completion in a short time, and proceeding under very mild conditions. ..