dieldrin

Summary

Summary: An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB)

Top Publications

  1. Briz V, Galofré M, Suñol C. Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation. Toxicol Sci. 2010;113:138-49 pubmed publisher
    b>Dieldrin was previously used as a pesticide. Although its use has been discontinued, humans are still exposed to it due to its high environmental persistence and because it accumulates in the adipose tissue of animals...
  2. Foster W, Mirshokraei P, Holloway A, Zhang B. Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice. Environ Res. 2008;108:21-7 pubmed publisher
    The objectives of this study were to: (1) determine the dosing range necessary to produce serum levels of dieldrin in mice representative of human body burdens; and (2) define the effect of developmental exposure to environmentally ..
  3. Slotkin T, MacKillop E, Ryde I, Tate C, Seidler F. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. Environ Health Perspect. 2007;115:93-101 pubmed
    ..different organophosphates (chlorpyrifos, diazinon, parathion), a carbamate (physostigmine), an organochlorine (dieldrin), and a metal (divalent nickel; Ni2+) and examined indices of cell replication and differentiation for both short-..
  4. Stevenson D, Walborg E, North D, Sielken R, Ross C, Wright A, et al. Monograph: reassessment of human cancer risk of aldrin/dieldrin. Toxicol Lett. 1999;109:123-86 pubmed
    In 1987, the US Environmental Protection Agency (EPA) classified aldrin and dieldrin as category B2 carcinogens, i.e. probable human carcinogens, based largely on the increase in liver tumors in mice fed either organochlorine insecticide...
  5. Kristensen M, Hansen K, Jensen K. Cross-resistance between dieldrin and fipronil in German cockroach (Dictyoptera: Blattellidae). J Econ Entomol. 2005;98:1305-10 pubmed
    The toxicity of fipronil and dieldrin was determined in one susceptible laboratory strain and seven insecticide-resistant field-collected strains of Blattella germanica (L)...
  6. Etang J, Manga L, Chandre F, Guillet P, Fondjo E, Mimpfoundi R, et al. Insecticide susceptibility status of Anopheles gambiae s.l. (Diptera: Culicidae) in the Republic of Cameroon. J Med Entomol. 2003;40:491-7 pubmed
    A large-scale survey of Anopheles gambiae Giles, 1902 susceptibility to DDT, dieldrin, permethrin, and deltamethrin was conducted in the Republic of Cameroon...
  7. Kitazawa M, Anantharam V, Kanthasamy A. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience. 2003;119:945-64 pubmed
    We previously reported that dieldrin, one of the potential environmental risk factors for development of Parkinson's disease, induces apoptosis in dopaminergic cells by generating oxidative stress...
  8. Zhao X, Salgado V, Yeh J, Narahashi T. Differential actions of fipronil and dieldrin insecticides on GABA-gated chloride channels in cockroach neurons. J Pharmacol Exp Ther. 2003;306:914-24 pubmed
    Fipronil and dieldrin are known to inhibit GABA receptors in both mammals and insects. However, the mechanism of selective toxicity of these insecticides between mammals and insects remains to be seen...
  9. Heusinkveld H, Westerink R. Organochlorine insecticides lindane and dieldrin and their binary mixture disturb calcium homeostasis in dopaminergic PC12 cells. Environ Sci Technol. 2012;46:1842-8 pubmed publisher
    ..link long-term environmental exposure of humans to persistent organochlorine (OC) insecticides lindane (HCH) and dieldrin (HEOD) to the development of neurodegenerative disorders, such as Parkinson's disease...

More Information

Publications62

  1. Yamada H, Jandrić Z, Chhem Kieth S, Vreysen M, Rathor M, Gilles J, et al. Anopheles arabiensis egg treatment with dieldrin for sex separation leaves residues in male adult mosquitoes that can bioaccumulate in goldfish (Carassius auratus auratus). Environ Toxicol Chem. 2013;32:2786-91 pubmed publisher
    ..sexing strain was developed whereby females can be eliminated by treating the eggs or larvae with the insecticide dieldrin. To evaluate the presence of dieldrin residues in male mosquitoes designated for SIT releases, a simple, ..
  2. Weisskopf M, Knekt P, O Reilly E, Lyytinen J, Reunanen A, Laden F, et al. Persistent organochlorine pesticides in serum and risk of Parkinson disease. Neurology. 2010;74:1055-61 pubmed publisher
    ..emerged with a summary score of the 5 organochlorine pesticides found at high levels, and only increasing dieldrin concentrations trended toward a higher risk of PD (OR per interquartile range [IQR] 1...
  3. Mao H, Fang X, Floyd K, Polcz J, Zhang P, Liu B. Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin. Brain Res. 2007;1186:267-74 pubmed
    ..b>Dieldrin, a highly persistent organochlorinated pesticide found enriched in the substantia nigra of some postmortem PD ..
  4. Hatcher J, Richardson J, Guillot T, McCormack A, Di Monte D, Jones D, et al. Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system. Exp Neurol. 2007;204:619-30 pubmed
    ..Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system...
  5. Richardson J, Caudle W, Wang M, Dean E, Pennell K, Miller G. Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB J. 2006;20:1695-7 pubmed
    ..Here, we report that perinatal exposure of mice during gestation and lactation to low levels of dieldrin (0...
  6. Wozniak A, Bulayeva N, Watson C. Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells. Environ Health Perspect. 2005;113:431-9 pubmed
    ..We investigated the effects of E2 versus several XEs representing organochlorine pesticides (dieldrin, endosulfan, o',p'-dichlorodiphenylethylene), plastics manufacturing by-products/detergents (nonylphenol, ..
  7. Stilwell G, ffrench Constant R. Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin. J Neurobiol. 1998;36:468-84 pubmed
    The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila...
  8. Snedeker S. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin. Environ Health Perspect. 2001;109 Suppl 1:35-47 pubmed
    ..I also discuss the emerging research on whether serum levels of the persistent organochlorine insecticide dieldrin are related to breast cancer risk in Danish and American women. Further research needs are also identified.
  9. Mao H, Liu B. Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin. Neuroreport. 2008;19:1317-20 pubmed publisher
    ..We report here that lindane and dieldrin, two widely present OCPs that are found enriched in the nigra of postmortem Parkinson's disease brains ..
  10. de Jong G, Swaen G, Slangen J. Mortality of workers exposed to dieldrin and aldrin: a retrospective cohort study. Occup Environ Med. 1997;54:702-7 pubmed
    To investigate the occurrence of long term health effects in humans exposed to aldrin and dieldrin, with an update of an earlier retrospective cohort mortality study...
  11. Cameron H, Foster W. Dieldrin promotes resistance to anoikis in breast cancer cells in vitro. Reprod Toxicol. 2008;25:256-62 pubmed publisher
    Epidemiological evidence suggests that exposure to the pesticide dieldrin, is associated with increased risk of breast cancer and mortality. We hypothesize that dieldrin promotes breast cancer by increasing survival of breast cancer cells...
  12. Damiens D, Vreysen M, Gilles J. Anopheles arabiensis sperm production after genetic manipulation, dieldrin treatment, and irradiation. J Med Entomol. 2013;50:314-6 pubmed
    ..genetic background of the original strain was first changed to create a genetic sexing strain that is based on a dieldrin-resistant mutation...
  13. Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy A. Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J Pharmacol Exp Ther. 2005;315:69-79 pubmed
    ..The organochlorine pesticide dieldrin is one of the environmental chemicals potentially linked to PD...
  14. Hope M, Menzies M, Kemp D. Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). J Econ Entomol. 2010;103:1355-9 pubmed
    ..have been characterized in many insect species, this report is the first to identify mutations associated with dieldrin resistance in the cattle tick...
  15. Slotkin T, Seidler F. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol Appl Pharmacol. 2008;233:211-9 pubmed publisher
    ..We contrasted effects of chlorpyrifos and diazinon, as well as non-OP neurotoxicants (dieldrin, Ni(2+)) using undifferentiated and differentiating PC12 cells, a well-established neurodevelopmental model...
  16. Tarraf C, El Sabban M, Bassam R, Beyrouthy M, Chamoun J, Talhouk R. Functional consequence of exposure to dieldrin on mammary development and function. Food Addit Contam. 2003;20:819-28 pubmed
    The effect of dieldrin (Dln) on the development of the mammary gland and on functional parameters of CID-9 mammary cells in culture was investigated...
  17. Kolaczinski J, Curtis C. Laboratory evaluation of fipronil, a phenylpyrazole insecticide, against adult Anopheles (Diptera: Culicidae) and investigation of its possible cross-resistance with dieldrin in Anopheles stephensi. Pest Manag Sci. 2001;57:41-5 pubmed
    ..4 and 4% of the cyclodiene insecticide dieldrin. Compared with the same doses of permethrin, fipronil showed less and delayed activity...
  18. Buznikov G, Nikitina L, Bezuglov V, Lauder J, Padilla S, Slotkin T. An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environ Health Perspect. 2001;109:651-61 pubmed
    ..b>Dieldrin, an organochlorine that targets GABA(A )receptors, was similarly ineffective...
  19. Hilber I, Wyss G, Mäder P, Bucheli T, Meier I, Vogt L, et al. Influence of activated charcoal amendment to contaminated soil on dieldrin and nutrient uptake by cucumbers. Environ Pollut. 2009;157:2224-30 pubmed publisher
    ..grown in agricultural soil with 0.07 mg kg(-1) of weathered dieldrin and 0, 200, 400, and 800 mg AC per kg soil...
  20. Kitazawa M, Anantharam V, Kanthasamy A. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radic Biol Med. 2001;31:1473-85 pubmed
    We examined the acute toxicity of dieldrin, a possible environmental risk factor of Parkinson's disease, in a dopaminergic cell model, PC12 cells, to determine early cellular events underlying the pesticide-induced degenerative processes...
  21. Park J, Kim S, Lee S, Kim C, Kim D, Kim S, et al. Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death. Neuroreport. 2008;19:1301-4 pubmed publisher
    ..In this study, we examined possible protective effects of CA on neurotoxicity induced by dieldrin, an organochlorine pesticide implicated in sporadic Parkinson's disease, in cultured dopaminergic cells (SN4741)...
  22. Cameron H, Foster W. Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice. PLoS ONE. 2009;4:e4303 pubmed publisher
    ..The organochlorine pesticide dieldrin is a persistent environmental toxicant thought to increase the risk of breast cancer and reduce survival in the ..
  23. Slotkin T, Seidler F. Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Res. 2009;1263:23-32 pubmed publisher
    ..We compared two organophosphate insecticides (chlorpyrifos, diazinon) with an organochlorine (dieldrin) and a metal (Ni(2+)) for similarities and differences in their effects on gene expression encoding subtypes of ..
  24. Sava V, Velasquez A, Song S, Sanchez Ramos J. Dieldrin elicits a widespread DNA repair and antioxidative response in mouse brain. J Biochem Mol Toxicol. 2007;21:125-35 pubmed
    b>Dieldrin is an organochlorine pesticide that is toxic for monoaminergic neurons...
  25. ffrench Constant R, Roush R, Mortlock D, Dively G. Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol. 1990;83:1733-7 pubmed
    High levels (about 4,000-fold) of resistance to dieldrin were isolated by screening field-collected populations of Drosophila melanogaster (Meigen). The resistance was made homozygous following 2-4 generations of selection...
  26. Corrigan F, Wienburg C, Shore R, Daniel S, Mann D. Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A. 2000;59:229-34 pubmed
    ..125 +/- 0.195; all differences from PD significant at p < .05, Mann-Whitney U-test). Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1,1'-(2,2-dichloroethenyl diene)-bis(4-..
  27. Martyniuk C, Kroll K, Doperalski N, Barber D, Denslow N. Genomic and proteomic responses to environmentally relevant exposures to dieldrin: indicators of neurodegeneration?. Toxicol Sci. 2010;117:190-9 pubmed publisher
    b>Dieldrin is a persistent organochlorine pesticide that induces neurotoxicity in the vertebrate central nervous system and impairs reproductive processes in fish...
  28. Vale C, Fonfria E, Bujons J, Messeguer A, Rodríguez Farré E, Suñol C. The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells. Neuroscience. 2003;117:397-403 pubmed
    The neurotoxic organochlorine pesticides gamma-hexachlorocyclohexane, alpha-endosulfan and dieldrin induce in mammals a hyperexcitability syndrome accompanied by convulsions. They reduce the GABA-induced Cl(-) flux...
  29. Matesic D, Blommel M, Sunman J, Cutler S, Cutler H. Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes. Cell Biol Toxicol. 2001;17:395-408 pubmed
    ..In this study, the organochlorine xenobiotics dieldrin and endosulfan, at micromolar concentrations, were found to inhibit gap junction-mediated intercellular ..
  30. Briz V, Molina Molina J, Sánchez Redondo S, Fernandez M, Grimalt J, Olea N, et al. Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures. Toxicol Sci. 2011;120:413-27 pubmed publisher
    The organochlorine chemicals endosulfan, dieldrin, and ?-hexachlorocyclohexane (lindane) are persistent pesticides to which people are exposed mainly via diet...
  31. Dodson S, Merritt C, Torrentera L, Winter K, Tornehl C, Girvin K. Dieldrin reduces male production and sex ratio in Daphnia galeata mendotae. Toxicol Ind Health. 1999;15:192-9 pubmed
    ..and fecundity and neonatal morphology, as an assay for detecting the effects of the insecticides endosulfan and dieldrin. Dieldrin caused a decrease in sex ratio (number of males/number of males plus females); we observed no ..
  32. Fowler P, Abramovich D, Haites N, Cash P, Groome N, Al Qahtani A, et al. Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations. Hum Reprod. 2007;22:2919-27 pubmed
    ..We investigated whether a model pesticide, dieldrin, at concentrations within both maternal circulation and environmental ranges (1 pmol/l = 0.0004 p.p.b. = 380...
  33. Brooke B, Hunt R, Matambo T, Koekemoer L, Van Wyk P, Coetzee M. Dieldrin resistance in the malaria vector Anopheles gambiae in Ghana. Med Vet Entomol. 2006;20:294-9 pubmed
    ..High levels of resistance to dieldrin were recorded in a wild-caught sample from Obuasi (south of Kumasi) as well as a laboratory colony established ..
  34. Gaytán B, Loguinov A, Lantz S, Lerot J, Denslow N, Vulpe C. Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast. Toxicol Sci. 2013;132:347-58 pubmed publisher
    Exposure to organochlorinated pesticides such as dieldrin has been linked to Parkinson's and Alzheimer's diseases, endocrine disruption, and cancer, but the cellular and molecular mechanisms of toxicity behind these effects remain largely ..
  35. Du W, Awolola T, Howell P, Koekemoer L, Brooke B, Benedict M, et al. Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis. Insect Mol Biol. 2005;14:179-83 pubmed publisher
    ..locus coding for a gamma-aminobutyric acid (GABA) receptor subunit with serine or glycine confer resistance to dieldrin in various insect species...
  36. Martyniuk C, Feswick A, Spade D, Kroll K, Barber D, Denslow N. Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus. Neurotoxicology. 2010;31:356-66 pubmed publisher
    Exposure to dieldrin induces neurotoxic effects in the vertebrate CNS and disrupts reproductive processes in teleost fish...
  37. Martyniuk C, Doperalski N, Kroll K, Barber D, Denslow N. Sexually dimorphic transcriptomic responses in the teleostean hypothalamus: a case study with the organochlorine pesticide dieldrin. Neurotoxicology. 2013;34:105-17 pubmed publisher
    Organochlorine pesticides (OCPs) such as dieldrin are a persistent class of aquatic pollutants that cause adverse neurological and reproductive effects in vertebrates...
  38. ffrench Constant R, Rocheleau T, Steichen J, Chalmers A. A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature. 1993;363:449-51 pubmed
    ..Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor...
  39. Wilkins E, Howell P, Benedict M. IMP PCR primers detect single nucleotide polymorphisms for Anopheles gambiae species identification, Mopti and Savanna rDNA types, and resistance to dieldrin in Anopheles arabiensis. Malar J. 2006;5:125 pubmed
    ..gambiae complex; (2) detection of the Mopti and Savanna rDNA types; and (3) an assay to distinguish resistance to dieldrin (Rdl) alleles in Anopheles arabiensis...
  40. Slotkin T, Seidler F. Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. Brain Res Bull. 2009;78:211-25 pubmed publisher
    ..and differences for organophosphate pesticides (chlorpyrifos, diazinon), an organochlorine pesticide (dieldrin) and a metal (Ni(2+)), focusing on transcriptional profiles related to differentiation into acetylcholine, ..
  41. Pelletier M, Roberge C, Gauthier M, Vandal K, Tessier P, Girard D. Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo. J Leukoc Biol. 2001;70:367-73 pubmed
    ..In this study, we found that the organochlorine insecticide dieldrin could not alter the ability of human neutrophils to phagocytose opsonized sheep red blood cells at nonnecrotic ..
  42. Jorgenson J. Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. Environ Health Perspect. 2001;109 Suppl 1:113-39 pubmed
    ..This review is a detailed examination of 2 of the 12 POPs, aldrin and dieldrin, and how scientific groups identify and measure their effects...
  43. Tantely M, Tortosa P, Alout H, Berticat C, Berthomieu A, Rutee A, et al. Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réunion Island. Insect Biochem Mol Biol. 2010;40:317-24 pubmed publisher
    ..test was developed to detect Rdl allele, encoding a gamma-aminobutyric acid (GABA) receptor resistant to dieldrin. Unexpectedly high Rdl frequencies were recorded over the whole island, despite this insecticide having been ..
  44. Kanthasamy A, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Mol Brain. 2008;1:12 pubmed publisher
    In previous work, we investigated dieldrin cytotoxicity and signaling cell death mechanisms in dopaminergic PC12 cells...
  45. Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy A. Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology. 2004;25:589-98 pubmed
    Previously, we demonstrated that the organochlorine pesticide dieldrin induces mitochondrial depolarization, caspase-3 activation and apoptosis in dopaminergic PC12 cells...
  46. Stedeford T, Cardozo Pelaez F, Nemeth N, Song S, Harbison R, Sanchez Ramos J. Comparison of base-excision repair capacity in proliferating and differentiated PC 12 cells following acute challenge with dieldrin. Free Radic Biol Med. 2001;31:1272-8 pubmed
    b>Dieldrin, an organochlorine pesticide and known neurotoxicant, is ubiquitously distributed in the environment. Dieldrin depletes brain monoamines in some animal species and is toxic for dopaminergic neurons in vitro...
  47. Brooke B, Hunt R, Coetzee M. Resistance to dieldrin + fipronil assorts with chromosome inversion 2La in the malaria vector Anopheles gambiae. Med Vet Entomol. 2000;14:190-4 pubmed
    ..We report resistance to dieldrin, a cyclodiene, in two laboratory strains of An...
  48. Thompson M, Steichen J, ffrench Constant R. Conservation of cyclodiene insecticide resistance-associated mutations in insects. Insect Mol Biol. 1993;2:149-54 pubmed
    ..The importance of single base pair substitutions in the evolution of pesticide resistance and in the design of molecular monitoring techniques is discussed. ..
  49. Kanthasamy A, Kitazawa M, Kanthasamy A, Anantharam V. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 2005;26:701-19 pubmed
    ..The organochlorine pesticide dieldrin has been found in human PD postmortem brain tissues, suggesting that this pesticide has potential to promote ..
  50. Wondji C, Dabire R, Tukur Z, Irving H, Djouaka R, Morgan J. Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the malaria vector Anopheles funestus in Africa. Insect Biochem Mol Biol. 2011;41:484-91 pubmed publisher
    ..Many agrochemicals target the GABA receptors, but cross-resistance from dieldrin resistance may preclude their introduction. Dieldrin resistance was detected in An...
  51. Saminathan H, Asaithambi A, Anantharam V, Kanthasamy A, Kanthasamy A. Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKC?-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology. 2011;32:567-77 pubmed publisher
    ..Exposure of N27 cells to the dopaminergic toxicant dieldrin (60 ?M) rapidly activated Fyn kinase, PKC?-tyr311 phosphorylation and proteolytic cleavage...
  52. Yamada H, Benedict M, Malcolm C, Oliva C, Soliban S, Gilles J. Genetic sex separation of the malaria vector, Anopheles arabiensis, by exposing eggs to dieldrin. Malar J. 2012;11:208 pubmed publisher
    ..A genetic sexing strain (GSS) of Anopheles arabiensis was created based on resistance to dieldrin, and methods of sex separation at the egg stage were developed...
  53. Hosie A, Baylis H, Buckingham S, Sattelle D. Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster. Br J Pharmacol. 1995;115:909-12 pubmed
    ..insecticide, fipronil, were examined on GABA responses recorded from Xenopus oocytes expressing either wild type (dieldrin-sensitive) or mutant (dieldrin-resistant) forms of the Drosophila melanogaster GABA-gated chloride channel homo-..