chlordecone

Summary

Summary: A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.

Top Publications

  1. Laessig S, Auger A, McCarthy M, Silbergeld E. Effects of prenatal chlordecone on sexually differentiated behavior in adult rats. Neurotoxicol Teratol. 2007;29:255-63 pubmed
    ..In this study, the effect of developmental exposure to the chlorinated pesticide, chlordecone (CD) on sexually differentiated behaviors in adults was investigated because CD binds to estrogen receptors and ..
  2. Mehendale H. Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses. Toxicol Lett. 1989;49:215-41 pubmed
    ..We developed such a model where prior exposure to non-toxic levels of the pesticide Kepone (chlordecone) results in a 67-fold amplification of CCl4 lethality in experimental animals...
  3. Murali B, Korrapati M, Warbritton A, Latendresse J, Mehendale H. Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity. Mech Ageing Dev. 2004;125:421-35 pubmed
    We have investigated the effects of chlordecone 1(CD)+CCl4 combination in adult (3 months), middle aged (14 months), and old aged (24 months) male Fischer 344 (F344) rats...
  4. Belfiore C, Yang R, Chubb L, Lohitnavy M, Lohitnavy O, Andersen M. Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling. Toxicology. 2007;234:59-72 pubmed
    b>Chlordecone (CD) and mirex (M) differ by a single carbonyl group in CD in place of two chlorines in M...
  5. Thakore K, Gargas M, Andersen M, Mehendale H. PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex. Toxicol Appl Pharmacol. 1991;109:514-28 pubmed
    ..Male Sprague-Dawley rats maintained for 15 days on normal diet (control), or on diets containing either chlordecone (CD, 10 ppm), phenobarbital (PB, 225 ppm) or mirex (M, 10 ppm), were used in gas uptake studies to determine ..
  6. Cabidoche Y, Achard R, Cattan P, Clermont Dauphin C, Massat F, Sansoulet J. Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue. Environ Pollut. 2009;157:1697-705 pubmed publisher
    b>Chlordecone was applied between 1972 and 1993 in banana fields of the French West Indies. This resulted in long-term pollution of soils and contamination of waters, aquatic biota, and crops...
  7. Kodavanti P, Kodavanti U, Faroon O, Mehendale H. Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. Toxicol Pathol. 1992;20:556-69 pubmed
    ..histomorphometric and biochemical studies suggested that the progressive phase of the interactive toxicity of chlordecone (CD) + CCl4 involves suppression of hepatocellular regeneration...
  8. Swartz W, Mall G. Chlordecone-induced follicular toxicity in mouse ovaries. Reprod Toxicol. 1989;3:203-6 pubmed
    The effect of the pesticide, chlordecone, on murine follicular development was examined. Female CD-1 mice were exposed to chlordecone for 5 consecutive days for each of 4 consecutive weeks (0.25 mg/day)...
  9. Jinna R, Uzodinma J, Desaiah D. Age-related changes in rat brain ATPases during treatment with chlordecone. J Toxicol Environ Health. 1989;27:199-208 pubmed
    b>Chlordecone was reported to produce neurotoxicity by modulating the Na+ pump in adult rat brain. The present in vitro and in vivo studies were initiated to investigate its effect on maturing rat brain ATPases...

More Information

Publications62

  1. Maier W, Costa L. Na+/K(+)-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: studies with chlordecone, organotins and mercury compounds. Toxicol Lett. 1990;51:175-88 pubmed
    ..The compounds chosen to test this hypothesis were the pesticide chlordecone, the organotin compounds triethyltin and tributyltin, mercuric chloride and methyl mercury...
  2. Multigner L, Ndong J, Giusti A, Romana M, Delacroix Maillard H, Cordier S, et al. Chlordecone exposure and risk of prostate cancer. J Clin Oncol. 2010;28:3457-62 pubmed publisher
    ..The estrogenic insecticide chlordecone was used extensively in the French West Indies, contaminating the population for more than 30 years...
  3. Dubuisson C, Heraud F, Leblanc J, Gallotti S, Flamand C, Blateau A, et al. Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone. Regul Toxicol Pharmacol. 2007;49:5-16 pubmed
    b>Chlordecone is an organochlorine insecticide used until 1993 in the banana plantations of the French Antilles. Recent surveys revealed its wide presence in the environment...
  4. Benachour N, Moslemi S, Sipahutar H, Seralini G. Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol. 2007;222:129-40 pubmed
    ..we tested aroclor 1254 (A1254), atrazine (AZ), o,p'-DDT, vinclozolin (VZ), p,p'-DDE, bisphenol A (BPA), chlordecone (CD), nonylphenol (NP), tributylin oxide (TBTO), and diethylstilbestrol (DES) for cellular toxicity against ..
  5. Lee J, Scheri R, Zhang Y, Curtis L. Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice. Toxicol Appl Pharmacol. 2008;233:193-202 pubmed publisher
    b>Chlordecone (CD) is one of many banned organochlorine (OC) insecticides that are widespread persistent organic pollutants. OC insecticides alter lipid homeostasis in rodents at doses that are not neurotoxic or carcinogenic...
  6. Guldner L, Multigner L, Heraud F, Monfort C, Thome J, Giusti A, et al. Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone. Environ Res. 2010;110:146-51 pubmed publisher
    b>Chlordecone, an environmentally persistent organochlorine insecticide used intensively in banana culture in the French West Indies until 1993, has permanently polluted soils and contaminated foodstuffs...
  7. Cai Z, Mehendale H. Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats. Pediatr Res. 1993;33:225-32 pubmed
    The interactive hepatotoxicity of CCl4 and chlordecone, at an individually nontoxic dosage, was studied in neonatal and young developing rats...
  8. Mottes C, Lesueur Jannoyer M, Le Bail M, Guéné M, Carles C, Malézieux E. Relationships between past and present pesticide applications and pollution at a watershed outlet: The case of a horticultural catchment in Martinique, French West Indies. Chemosphere. 2017;184:762-773 pubmed publisher
    ..We identified three types of pollution. First, we showed long-term chronic pollution by chlordecone, diuron and metolachlor resulting from horticultural practices applied 5-20 years ago (quantification frequency ..
  9. Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R. Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006;79:1160-9 pubmed
    ..and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively...
  10. Kadhel P, Monfort C, Costet N, Rouget F, Thome J, Multigner L, et al. Chlordecone exposure, length of gestation, and risk of preterm birth. Am J Epidemiol. 2014;179:536-44 pubmed publisher
    ..b>Chlordecone is an organochlorine pesticide that has been extensively used to control the banana root borer population in ..
  11. Andersen M, Clewell H, Gearhart J, Allen B, Barton H. Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors. J Toxicol Environ Health. 1997;52:189-209 pubmed
    ..With further development these pharmacodynamic estrus cycle models should be useful in aiding risk assessments for compounds causing mammary-tissue tumors associated with persistent estrus states. ..
  12. Shelby M, Newbold R, Tully D, Chae K, Davis V. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect. 1996;104:1296-300 pubmed
  13. Flouriot G, Pakdel F, Ducouret B, Valotaire Y. Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression. J Mol Endocrinol. 1995;15:143-51 pubmed
    ..We showed that chlordecone, nonylphenol, a polychlorobiphenol (PCB) mixture (Aroclor 1245) and lindane were able to induce ER and Vg mRNA ..
  14. Chetty K, Walker J, Brown K, Ivie G. Influence of dietary calcium on chlordecone-induced biochemical changes in serum of rat. Ecotoxicol Environ Saf. 1993;26:248-52 pubmed
    Male, Sprague-Dawley rats were treated with different (1, 10, 50, and 100 ppm) concentrations of chlordecone (Cd) in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days...
  15. Fujimori K, Benet H, Mehendale H, Ho I. In vivo and in vitro synthesis, release, and uptake of [3-H]-dopamine in mouse striatal slices after in vivo exposure to chlordecone. J Biochem Toxicol. 1986;1:1-12 pubmed
    Effects of treatment of mice with chlordecone (25 mg/kg/d) on striatal dopaminergic activities such as synthesis, turnover, uptake, and release were investigated in vivo and in vitro...
  16. Bondy S, McKee M. Prevention of chemically induced synaptosomal changes. J Neurosci Res. 1990;25:229-35 pubmed
    ..Incubation conditions used included the presence of methyl mercury or an organochlorine insecticide: chlordecone. Other adverse chemical conditions during incubation were the absence of calcium salts from the incubation ..
  17. Purushotham K, Lockard V, Mehendale H. Amplification of chloroform hepatotoxicity and lethality by dietary chlordecone (kepone) in mice. Toxicol Pathol. 1988;16:27-34 pubmed
    Male Swiss Webster mice (25-30 g) maintained on powdered control diet, or on diets containing chlordecone (CD, 10 ppm), mirex (M, 10 ppm), or phenobarbital (PB, 225 ppm) were used in this study...
  18. Curtis L. Chlordecone is a potent in vitro inhibitor of oligomycin-insensitive Mg2+ -ATPase of rat bile canaliculi-enriched fraction. J Biochem Toxicol. 1988;3:321-8 pubmed
    ..Mg2+ -ATPase (OIMATPase) of rat bile canaliculi-enriched fraction (BCEF) was inhibited by chlordecone (CD) in vitro (IC-50 = 25 microM). Kinetic analysis indicated noncompetitive inhibition...
  19. Thomas P, Dong J. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. J Steroid Biochem Mol Biol. 2006;102:175-9 pubmed
    ..The results indicate that nontraditional estrogen actions mediated through GPR30 are potentially susceptible to disruption by a variety of environmental estrogens. ..
  20. Dahlström King L, Couture J, Plaa G. Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis. Toxicol Lett. 1992;63:243-52 pubmed
    ..Phenobarbital, 3-methylcholanthrene, chlordecone or mirex were used as inducers, and SKF 525-A, piperonyl butoxide, or cobaltous chloride as inhibitors of ..
  21. Legrand E, Forget Leray J, Duflot A, Olivier S, Thome J, Danger J, et al. Transcriptome analysis of the copepod Eurytemora affinis upon exposure to endocrine disruptor pesticides: Focus on reproduction and development. Aquat Toxicol. 2016;176:64-75 pubmed publisher
    ..Copepods were exposed to sublethal concentrations of pyriproxyfen (PXF) and chlordecone (CLD) separately. After 48h, males and females (400 individuals each) were sorted for RNA extraction...
  22. Mallatt J, Stinson C. Toxicant extraction efficiency and branchial NaCl fluxes in lampreys exposed to Kepone. Arch Environ Contam Toxicol. 1990;19:307-13 pubmed
    ..These latter findings are difficult to reconciliate with accepted theories of Kepone's toxic action; they may relate to the fact that lampreys are unusually tolerant to Kepone poisoning. ..
  23. Bondy S, McKee M, Davoodbhoy Y. Prevention of chemically induced changes in synaptosomal membrane order by ganglioside GM1 and alpha-tocopherol. Biochim Biophys Acta. 1990;1026:213-9 pubmed
    ..b>Chlordecone, a neurotoxic insecticide, decreased the anisotropy of either dye and this change could be prevented by prior ..
  24. Kodavanti P, Cameron J, Yallapragada P, Desaiah D. Effect of chlordecone (Kepone) on calcium transport mechanisms in rat heart sarcoplasmic reticulum. Pharmacol Toxicol. 1990;67:227-34 pubmed
    Previous studies from our laboratory have indicated that chlordecone (Kepone CD), an organochlorine insecticide, inhibited cardiac sodium pump activity and catecholamine uptake suggesting that CD may interfere with cardiac function...
  25. Faroon O, Mehendale H. Bromotrichloromethane hepatotoxicity. The role of stimulated hepatocellular regeneration in recovery: biochemical and histopathological studies in control and chlordecone pretreated male rats. Toxicol Pathol. 1990;18:667-77 pubmed
    ..Pretreatment with nontoxic dietary levels of chlordecone (CD) results in amplification of BrCCl3 hepatotoxicity...
  26. Starcevic S, Bortolin S, Woodcroft K, Novak R. Kepone (chlordecone) disrupts adherens junctions in human breast epithelial cells cultured on matrigel. In Vivo. 2001;15:289-94 pubmed
    ..1 and 1.0 microM Kepone. Thus, Kepone disrupts cellular architecture, specifically E-cadherin-gamma-catenin containing adherens junctions, which may ultimately affect cellular phenotype. ..
  27. Hodges L, Bergerson J, Hunter D, Walker C. Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol Sci. 2000;54:355-64 pubmed
  28. Schrader T, Cooke G. Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol Sci. 2000;53:278-88 pubmed
    ..Thus, of the chemicals tested, some interact with the human androgen receptor in vitro as agonists, others as antagonists, and some as partial agonists/antagonists. ..
  29. Hegarty J, Glende E, Recknagel R. Potentiation by chlordecone of the defect in hepatic microsomal calcium sequestration induced by carbon tetrachloride. J Biochem Toxicol. 1986;1:73-8 pubmed
    ..on the capacity of hepatic microsomes to sequester calcium was studied following pretreatment of rats with chlordecone. Chlordecone pretreatment alone had no effect on the kinetics of calcium uptake by hepatic microsomes...
  30. Wang F, Sobel E, Butfiloski E, Roberts S. Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice. Toxicol Lett. 2008;183:1-9 pubmed publisher
    ..Treatment with estrogenic organochlorine pesticides (OCPs) such as chlordecone produces a similar effect...
  31. Lewandowski M, Levi P, Hodgson E. Induction of cytochrome P-450 isozymes by mirex and chlordecone. J Biochem Toxicol. 1989;4:195-9 pubmed
    ..Mice were treated intraperitoneally with low (6 mg/kg) and high (30 mg/kg) doses of mirex and chlordecone in corn oil for 2 days...
  32. Gamboa Carballo J, Melchor Rodríguez K, Hernández Valdés D, Enriquez Victorero C, Montero Alejo A, Gaspard S, et al. Theoretical study of chlordecone and surface groups interaction in an activated carbon model under acidic and neutral conditions. J Mol Graph Model. 2016;65:83-93 pubmed publisher
    ..b>Chlordecone (CLD, Kepone) is an organochlorinated synthetic compound that has been used mainly as agricultural insecticide...
  33. Clostre F, Lesueur Jannoyer M, Achard R, Letourmy P, Cabidoche Y, Cattan P. Decision support tool for soil sampling of heterogeneous pesticide (chlordecone) pollution. Environ Sci Pollut Res Int. 2014;21:1980-1992 pubmed publisher
    When field pollution is heterogeneous due to localized pesticide application, as is the case of chlordecone (CLD), the mean level of pollution is difficult to assess...
  34. Woignier T, Clostre F, Macarie H, Jannoyer M. Chlordecone retention in the fractal structure of volcanic clay. J Hazard Mater. 2012;241-242:224-30 pubmed publisher
    b>Chlordecone (CHLD), a soil and foodstuff pollutant, as well as an environmentally persistent organochlorine insecticide, was used intensively in banana fields...
  35. Kocarek T, Schuetz E, Guzelian P. Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. Mol Pharmacol. 1991;40:203-10 pubmed
    ..Kepone (chlordecone) treatment of the cultures increased P450e mRNA in a dose-dependent manner that disclosed a 10-fold greater ..
  36. Eckols K, Williams J, Uphouse L. Effects of chlordecone on progesterone receptors in immature and adult rats. Toxicol Appl Pharmacol. 1989;100:506-16 pubmed
    The ability of the chlorinated pesticide chlordecone to induce the CNS (hypothalamus and preoptic area) plus pituitary and uterine progesterone receptors was examined in CDF-344 female rats following treatment with 25 micrograms ..
  37. Crouch L, Ebel R. Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction. Xenobiotica. 1987;17:859-67 pubmed
    ..of benzo[a]pyrene (BP) by gerbil hepatic microsomes is increased following induction by phenobarbital (PB), chlordecone, mirex and 3-methylcholanthrene (3-MC). 2...
  38. Calabrese E, Baldwin L, Mehendale H. G2 subpopulation in rat liver induced into mitosis by low-level exposure to carbon tetrachloride: an adaptive response. Toxicol Appl Pharmacol. 1993;121:1-7 pubmed
    Recent findings by Mehendale (Med. Hypoth. 33, 289-299, 1990) indicate that prior exposure to chlordecone markedly enhances CCl4-induced lethality...
  39. Mehendale H. Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism. Med Hypotheses. 1990;33:289-99 pubmed
    ..One such model is available, where prior exposure to nontoxic levels of the pesticide Kepone (chlordecone) results in a 67-fold amplication of CCl4 lethality in rats...
  40. Das S, Thomas P. Pesticides interfere with the nongenomic action of a progestogen on meiotic maturation by binding to its plasma membrane receptor on fish oocytes. Endocrinology. 1999;140:1953-6 pubmed
  41. Johnson D. Estradiol-chlordecone (Kepone) interactions: additive effect of combinations for uterotropic and embryo implantation functions. Toxicol Lett. 1996;89:57-64 pubmed
    b>Chlordecone (Kepone) is a polychlorinated hydrocarbon that has a low affinity for the estrogen receptor...
  42. Britton R, Dolak J, Glende E, Recknagel R. Potentiation of carbon tetrachloride hepatotoxicity by chlordecone: dose-response relationships and increased covalent binding in vivo. J Biochem Toxicol. 1987;2:43-55 pubmed
    b>Chlordecone greatly potentiates carbon tetrachloride (CCl4) hepatotoxicity...
  43. Sirica A, Wilkerson C, Wu L, Fitzgerald R, Blanke R, Guzelian P. Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. Carcinogenesis. 1989;10:1047-54 pubmed
    b>Chlordecone (Kepone) has been extensively studied for its toxicity in male production workers who were exposed to large quantities of this organochlorine pesticide...
  44. Lerch S, Guidou C, Thome J, Jurjanz S. Non-dioxin-like Polychlorinated Biphenyls (PCBs) and Chlordecone Release from Adipose Tissue to Blood in Response to Body Fat Mobilization in Ewe (Ovis aries). J Agric Food Chem. 2016;64:1212-20 pubmed publisher
    ..The current study aimed to determine in nonlactating ewes whether polychlorinated biphenyls (PCBs) and chlordecone are released from AT to blood along with lipids during body fat mobilization achieved through ?-agonist ..
  45. Rao S, Young R, Mehendale H. Hepatic polyamines and related enzymes following chlordecone-potentiated carbon tetrachloride toxicity in rats. J Biochem Toxicol. 1989;4:55-63 pubmed
    b>Chlordecone potentiation of the hepatotoxic and lethal effects of CCL4 has been well established...
  46. Brown H, Salamanca S, Stewart G, Uphouse L. Chlordecone (Kepone) on the night of proestrus inhibits female sexual behavior in CDF-344 rats. Toxicol Appl Pharmacol. 1991;110:97-106 pubmed
    The effect of the estrogen-like chlorinated pesticide chlordecone (Kepone) on sexual behavior was examined in proestrous rats following treatment with 25, 50, or 75 mg/kg chlordecone...
  47. Cook L, Edens F, Tilson H. Possible brainstem involvement in the modification of thermoregulatory processes by chlordecone in rats. Neuropharmacology. 1988;27:871-9 pubmed
    The involvement of the central nervous system in the hypothermia induced by chlordecone was studied by evaluating the effects of infusions of chlordecone injected into the lateral and third ventricles and the cisterna magna on colonic ..
  48. Merlin C, Devers M, Béguet J, Boggio B, Rouard N, Martin Laurent F. Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function. Environ Sci Pollut Res Int. 2016;23:4185-98 pubmed publisher
    The insecticide chlordecone applied for decades in banana plantations currently contaminates 20,000 ha of arable land in the French West Indies...
  49. El Masri H, Thomas R, Benjamin S, Yang R. Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment. Toxicology. 1995;105:275-82 pubmed
  50. Meng Y, Zou E. Impacts of molt-inhibiting organochlorine compounds on epidermal ecdysteroid signaling in the fiddler crab, Uca pugilator, in vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2009;150:436-41 pubmed publisher
    ..PCB29, when given together with 20-HE, produced an additive effect on epidermal ecdysteroid signaling but such an additive effect was not observed when kepone was combined with 20-HE. ..
  51. Dolak J, Britton R, Glende E, Recknagel R. Chlordecone does not interfere with hepatic repair after carbon tetrachloride or partial hepatectomy. J Biochem Toxicol. 1987;2:57-66 pubmed
    The effect of chlordecone (CD) on hepatic repair, measured either as recovery of microsomal enzymatic functions or as the induction of cytosolic thymidine kinase (TK) activity, was evaluated in rats given carbon tetrachloride (CCl4)...
  52. Mehendale H, Purushotham K, Lockard V. The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity. Exp Mol Pathol. 1989;51:31-47 pubmed
    The mechanism by which chlordecone (CD) potentiates CHCl3 hepatotoxicity and lethality remains unknown...
  53. Soni M, Mehendale H. Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: biochemical and histological studies. Toxicol Appl Pharmacol. 1991;108:46-57 pubmed
    b>Chlordecone (CD) pretreatment is well known to greatly potentiate CCl4 toxicity. Previous work has shown that suppression of hepatocellular regeneration permits an ordinarily limited liver injury to progress in an irreversible manner...