phloroglucinol

Summary

Summary: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.

Top Publications

  1. Kong C, Kim J, Yoon N, Kim S. Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells. Food Chem Toxicol. 2009;47:1653-8 pubmed publisher
    b>Phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from Ecklonia Cava...
  2. Kang K, Zhang R, Chae S, Lee S, Kim J, Kim J, et al. Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo. Chem Biol Interact. 2010;185:215-26 pubmed publisher
    ..We have investigated the radioprotective effect of phloroglucinol (1,3,5-trihydroxybenzene), phlorotannin compound isolated from Ecklonia cava, against gamma-ray radiation-..
  3. Liu J, Yang W, Fong Y, Kuo S, Chang C, Tang C. BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress. Biochem Pharmacol. 2010;79:1410-7 pubmed publisher
    ..This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (2,4-bis(2-fluorophenylacetyl)phloroglucinol; BFPP) in human chondrosarcoma cells...
  4. Lee J, Duke R, Tran V, Hook J, Duke C. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry. 2006;67:2550-60 pubmed
    ..63 microM) and furohyperforin (IC(50) 1.3 microM). As the acylphloroglucinols are potent inhibitors of the CYP3A4 enzyme, their modulation of the enzyme activity is unlikely to be involved in increased drug metabolism by St. John's wort. ..
  5. Park S, Ahn G, Lee N, Park J, Jeon Y, Jee Y. Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes. Food Chem Toxicol. 2011;49:2236-42 pubmed publisher
    b>Phloroglucinol (PG), a polyphenol compound of Eckloniacava known as brown algae abundant in Jeju island, has been proposed to exert the antioxidative and cytoprotective effects against oxidative stress...
  6. Rosa A, Deiana M, Atzeri A, Corona G, Incani A, Melis M, et al. Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. Chem Biol Interact. 2007;165:117-26 pubmed
    ..Arzanol, a pyrone-phloroglucinol etherodimer, and helipyrone, a dimeric pyrone, showed antioxidant activity, and could protect linoleic acid ..
  7. Li Y, Lee S, Le Q, Kim M, Kim S. Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI. J Agric Food Chem. 2008;56:12073-80 pubmed publisher
    Two bioactive phloroglucinol derivatives, fucodiphloroethol G (1) and phlorofucofuroeckol A (3) were first isolated from Eckolonia cava (EC) and characterized by nuclear magnetic resonance (NMR) spectroscopic methods, along with eckol (2)...
  8. Frapolli M, Pothier J, Défago G, Moënne Loccoz Y. Evolutionary history of synthesis pathway genes for phloroglucinol and cyanide antimicrobials in plant-associated fluorescent pseudomonads. Mol Phylogenet Evol. 2012;63:877-90 pubmed publisher
  9. Liu J, Liu Z, Wang D, Li M, Wang S, Wang R, et al. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011;190:91-101 pubmed publisher
    Hyperforin is an abundant phloroglucinol-type constituent isolated from the extract of the flowering upper portion of the plant Hypericum perforatum L...

More Information

Publications63

  1. Rosa A, Pollastro F, Atzeri A, Appendino G, Melis M, Deiana M, et al. Protective role of arzanol against lipid peroxidation in biological systems. Chem Phys Lipids. 2011;164:24-32 pubmed publisher
    This study examines the protective effect of arzanol, a pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp...
  2. Gey C, Kyrylenko S, Hennig L, Nguyen L, Büttner A, Pham H, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46:5219-22 pubmed
  3. Rothley M, Schmid A, Thiele W, Schacht V, Plaumann D, Gartner M, et al. Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo. Int J Cancer. 2009;125:34-42 pubmed publisher
    The phloroglucinol derivative hyperforin, a major bioactive constituent of St. John's wort, is increasingly recognized as being able to regulate a variety of pathobiological processes and, thus, to possess potential therapeutic properties...
  4. Ryu J, Zhang R, Hong B, Yang E, Kang K, Choi M, et al. Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity. PLoS ONE. 2013;8:e71178 pubmed publisher
    In this study, we investigated whether phloroglucinol (1,3,5-trihydroxybenzene) has therapeutic effects in cellular and animal model of Parkinson's disease (PD)...
  5. Brazelton J, Pfeufer E, Sweat T, Gardener B, Coenen C. 2,4-diacetylphloroglucinol alters plant root development. Mol Plant Microbe Interact. 2008;21:1349-58 pubmed publisher
    ..These results indicate that DAPG can alter crop root architecture by interacting with an auxin-dependent signaling pathway. ..
  6. Quiney C, Billard C, Faussat A, Salanoubat C, Kolb J. Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells. Leuk Lymphoma. 2007;48:1587-99 pubmed
    We showed previously that hyperforin (HF), a natural phloroglucinol, stimulated apoptosis in B cell chronic lymphocytic leukaemia cells (CLL) and displayed anti-angiogenic properties...
  7. Andrew R, Wallis I, Harwood C, Henson M, Foley W. Heritable variation in the foliar secondary metabolite sideroxylonal in Eucalyptus confers cross-resistance to herbivores. Oecologia. 2007;153:891-901 pubmed
  8. Shibaya T, Sugawara Y. Induction of multinucleation by beta-glucosyl Yariv reagent in regenerated cells from Marchantia polymorpha protoplasts and involvement of arabinogalactan proteins in cell plate formation. Planta. 2009;230:581-8 pubmed publisher
    ..Our results indicated that AGPs might have an important role in cell plate formation, and perturbation of AGPs with betaglcY might result in remarkable multinucleation in protoplast-regenerated cells of M. polymorpha...
  9. Magalhaes L, Kapadia G, da Silva Tonuci L, Caixeta S, Parreira N, Rodrigues V, et al. In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms. Parasitol Res. 2010;106:395-401 pubmed publisher
    ..The aim of this work was to evaluate the in vitro schistosomicidal activity of some phloroglucinol compounds, obtained from the rhizomes of Dryopteris species, against Schistosoma mansoni adult worms...
  10. Cerpa W, Hancke J, Morazzoni P, Bombardelli E, Riva A, Marin P, et al. The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Curr Alzheimer Res. 2010;7:126-33 pubmed
    ..We conclude that the hyperforin derivative, IDN5706, has therapeutic potential for prevention and treatment of AD. ..
  11. Bauer J, Koeberle A, Dehm F, Pollastro F, Appendino G, Northoff H, et al. Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochem Pharmacol. 2011;81:259-68 pubmed publisher
    ..italicum, and a rationale for further pre-clinical evaluation of this novel anti-inflammatory lead. ..
  12. Yang W, Stockwell B. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 2008;9:R92 pubmed publisher
    ..These data support the hypothesis that circadian clock genes can control the cell cycle and cell survival signaling, and emphasize a central role of CK1epsilon and PERIOD2 in linking these systems. ..
  13. Chang M, Chang H, Chan C, Chou H, Chang B, Yeung S, et al. Antiplatelet effect of phloroglucinol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Toxicol Appl Pharmacol. 2012;263:287-95 pubmed publisher
    ..Many antiplatelet agents are used for prevention and treatment of these diseases. In this study, phloroglucinol (2...
  14. Gupta P, Kumar R, Garg P, Singh I. Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase. Bioorg Med Chem Lett. 2010;20:4427-31 pubmed publisher
    In a recent report on anti-HIV activity of dimeric phloroglucinol compounds, seven out of twenty one compounds were shown to possess good activity in HIV infected human CD4+ T cell line...
  15. Freeman J, O Reilly Wapstra J, Vaillancourt R, Wiggins N, Potts B. Quantitative trait loci for key defensive compounds affecting herbivory of eucalypts in Australia. New Phytol. 2008;178:846-51 pubmed publisher
    ..Given the potential widespread occurrence of these QTL, their ontogenetic stability, and their impact on a range of dependent herbivores, it is possible that they have extended phenotypic effects in the Australian forest landscape. ..
  16. Verotta L, Appendino G, Bombardelli E, Brun R. In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study. Bioorg Med Chem Lett. 2007;17:1544-8 pubmed
    ..Related phloroglucinols like the hop beta-acids and the enantiomers of usnic acid showed only marginal activity, suggesting that hyperforin is a new antimalarial chemotype. ..
  17. Bae J. Antithrombotic and profibrinolytic activities of phloroglucinol. Food Chem Toxicol. 2011;49:1572-7 pubmed publisher
    b>Phloroglucinol is the monomeric units of phlorotannins abundant in brown algae...
  18. Andrew R, Wallis I, Harwood C, Foley W. Genetic and environmental contributions to variation and population divergence in a broad-spectrum foliar defence of Eucalyptus tricarpa. Ann Bot. 2010;105:707-17 pubmed publisher
    ..Sideroxylonal (a formylated phloroglucinol compound or FPC) is an important chemical defence in eucalypts...
  19. Bicker J, Petereit F, Hensel A. Proanthocyanidins and a phloroglucinol derivative from Rumex acetosa L. Fitoterapia. 2009;80:483-95 pubmed publisher
    ..as free phenols or peracetylated derivatives and, in part, after partial acid-catalysed degradation with phloroglucinol. A more abundant proanthocyanidin polymer was also isolated, purified and its chemical composition studied by (..
  20. Huang S, Cheung C, Chang C, Tang C, Liu J, Lin Y, et al. Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. J Cell Biochem. 2011;112:643-52 pubmed publisher
    This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (3,6-bis(3-chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells...
  21. Tian L, Zhang Y, Qu C, Wang Y, Yang C. Phloroglucinol glycosides from the fresh fruits of Eucalyptus maideni. J Nat Prod. 2010;73:160-3 pubmed publisher
    Five new phloroglucinol glycosides, eucalmainosides A-E (1-5), were isolated from the fresh fruits of Eucalyptus maideni, along with 15 flavonoids (6-20), seven (+)-oleuropeic acid derivatives (15, 16, and 22-26), three hydrolyzable ..
  22. Dell Aica I, Caniato R, Biggin S, Garbisa S. Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine. Clin Chim Acta. 2007;381:69-77 pubmed
    ..Modern research clearly vindicates epidemiological and historical evidence of the beneficial effects of two long-used allies from the plant kingdom, going a step beyond by shedding light on mechanistic keys. ..
  23. Lu D, Chang C, Yeh W, Tang C, Cheung C, Leung Y, et al. The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine. 2012;19:1093-100 pubmed publisher
    Prenyl-phloroglucinol derivatives from hop plants have been shown to have anticancer activities...
  24. Moon H. Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum Thunb. Phytother Res. 2010;24:941-4 pubmed publisher
    ..Five phloroglucinol derivatives, otogirin (1), otogirone (2), erectquione A (3), erectquione B (4), and erectquione C (5) were ..
  25. Yang F, Cao Y. Biosynthesis of phloroglucinol compounds in microorganisms--review. Appl Microbiol Biotechnol. 2012;93:487-95 pubmed publisher
    b>Phloroglucinol derivatives are a major class of secondary metabolites of wide occurrence in biological systems. In the bacteria kingdom, these compounds can only be synthesized by some species of Pseudomonads. Pseudomonas spp...
  26. Chauthe S, Bharate S, Sabde S, Mitra D, Bhutani K, Singh I. Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols. Bioorg Med Chem. 2010;18:2029-36 pubmed publisher
    ..Compounds 22 and 24 showed highest anti-HIV activity with an IC(50) of 0.28 microM and 2.71 microM, respectively, former was more active than the positive standard AZT in cell based assay. ..
  27. Kim S, Dunn I, Firestein R, Gupta P, Wardwell L, Repich K, et al. CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS ONE. 2010;5:e8979 pubmed publisher
  28. Kim M, Kim S. Effect of phloroglucinol on oxidative stress and inflammation. Food Chem Toxicol. 2010;48:2925-33 pubmed publisher
    The aim of this study is to investigate the inhibitory effect of phloroglucinol on oxidative stress and inflammation. Phloroglucinol is a monomer of phlorotannins abundant in brown algae...
  29. Tian T, Wu X, Duan H, Zhang L. The resistance-nodulation-division efflux pump EmhABC influences the production of 2,4-diacetylphloroglucinol in Pseudomonas fluorescens 2P24. Microbiology. 2010;156:39-48 pubmed publisher
    ..In conclusion, our results suggest that the EmhABC system is an important element that influences the production of antibiotic 2,4-DAPG and enhances resistance to toxic compounds in P. fluorescens 2P24. ..
  30. Hu Y, Qin Y, Zhao J. Localization of an arabinogalactan protein epitope and the effects of Yariv phenylglycoside during zygotic embryo development of Arabidopsis thaliana. Protoplasma. 2006;229:21-31 pubmed
    ..The possible roles of AGPs in A. thaliana zygotic embryo development are also discussed. ..
  31. Müller M, Essin K, Hill K, Beschmann H, Rubant S, Schempp C, et al. Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. J Biol Chem. 2008;283:33942-54 pubmed publisher
    ..Therefore, TRPC6 activation by hyperforin may represent a new innovative therapeutic strategy in skin disorders characterized by altered keratinocyte differentiation. ..
  32. Kidarsa T, Goebel N, Zabriskie T, Loper J. Phloroglucinol mediates cross-talk between the pyoluteorin and 2,4-diacetylphloroglucinol biosynthetic pathways in Pseudomonas fluorescens Pf-5. Mol Microbiol. 2011;81:395-414 pubmed publisher
    ..The first step in DAPG biosynthesis is production of phloroglucinol (PG) by PhlD...
  33. Henery M, Moran G, Wallis I, Foley W. Identification of quantitative trait loci influencing foliar concentrations of terpenes and formylated phloroglucinol compounds in Eucalyptus nitens. New Phytol. 2007;176:82-95 pubmed
    ..Leaves of eucalypt species contain a variety of plant secondary metabolites, including terpenoids and formylated phloroglucinol compounds (FPCs)...
  34. Chassany O, Bonaz B, Bruley des Varannes S, Bueno L, Cargill G, Coffin B, et al. Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol. A randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2007;25:1115-23 pubmed
    Abdominal pain is the predominant symptom in irritable bowel syndrome patients. Phloroglucinol and its methylated derivative are antispasmodic agents acting on smooth muscle...
  35. Appendino G, Ottino M, Marquez N, Bianchi F, Giana A, Ballero M, et al. Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum. J Nat Prod. 2007;70:608-12 pubmed
    An acetone extract of Helichrysum italicum ssp. microphyllum afforded the phloroglucinol alpha-pyrone arzanol (1a) as a potent NF-kappaB inhibitor. Arzanol is identical with homoarenol (2a), whose structure should be revised...
  36. Cao Y, Jiang X, Zhang R, Xian M. Improved phloroglucinol production by metabolically engineered Escherichia coli. Appl Microbiol Biotechnol. 2011;91:1545-52 pubmed publisher
    b>Phloroglucinol is a valuable chemical which has been successfully produced by metabolically engineered Escherichia coli. However, the low productivity remains a bottleneck for large-scale application and cost-effective production...
  37. Kwon Y, Jung S, Kim J, Lee S, Lee J, Lee B, et al. Phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in LLC-tumor-bearing mice. PLoS ONE. 2012;7:e33618 pubmed publisher
    There is increasing evidence that phloroglucinol, a compound from Ecklonia cava, induces the apoptosis of cancer cells, eventually suppressing tumor angiogenesis...
  38. Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, et al. Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell Mol Life Sci. 2009;66:2759-71 pubmed publisher
    ..Together, hyperforin is a novel type of 5-LO inhibitor apparently acting by interference with the C2-like domain, with high effectiveness in vivo. ..
  39. Dutta S, Basak A, Dasgupta S. Synthesis and ribonuclease A inhibition activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin: Importance of hydroxyl groups. Bioorg Med Chem. 2010;18:6538-46 pubmed publisher
    ..green tea extracts prompted us to synthesize novel catechin/epicatechin based conjugates with resorcinol and phloroglucinol with the aim to increase the number of phenolic OH groups...
  40. Wu X, Duan H, Tian T, Yao N, Zhou H, Zhang L. Effect of the hfq gene on 2,4-diacetylphloroglucinol production and the PcoI/PcoR quorum-sensing system in Pseudomonas fluorescens 2P24. FEMS Microbiol Lett. 2010;309:16-24 pubmed publisher
    ..Based on these results, we propose that Hfq functions as an important regulatory element in the complex network controlling environmental adaption in P. fluorescens 2P24...
  41. Griffith T, Varela Nallar L, Dinamarca M, Inestrosa N. Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Curr Med Chem. 2010;17:391-406 pubmed
    St. John's Wort (SJW) has been used medicinally for over 5,000 years. Relatively recently, one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest...
  42. Shim S, Choi J, Byun D. Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on Fc(epsilon)RI expression. Bioorg Med Chem. 2009;17:4734-9 pubmed publisher
    Two bioactive phloroglucinol derivatives, dioxinodehydroeckol (DHE) and phlorofucofuroeckol A (PFF-A) were isolated from edible marine brown alga, Ecklonia stolonifera, and evaluated for effects on cell surface Fc(epsilon)RI expression in ..
  43. Lorusso G, Vannini N, Sogno I, Generoso L, Garbisa S, Noonan D, et al. Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. Eur J Cancer. 2009;45:1474-84 pubmed publisher
  44. Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, et al. Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J. 2007;21:4101-11 pubmed
    ..Hyperforin integrates inhibition of neurotransmitter uptake and neurotrophic property by specific activation of TRPC6 and represents an interesting lead-structure for a new class of antidepressants. ..
  45. Moore B, Foley W, Wallis I, Cowling A, Handasyde K. Eucalyptus foliar chemistry explains selective feeding by koalas. Biol Lett. 2005;1:64-7 pubmed
    ..We tested whether a recently discovered group of plant secondary metabolites, the formylated phloroglucinol compounds (FPCs), deters koalas from feeding on some eucalypt foliage...
  46. Sardar H, Yang J, Showalter A. Molecular interactions of arabinogalactan proteins with cortical microtubules and F-actin in Bright Yellow-2 tobacco cultured cells. Plant Physiol. 2006;142:1469-79 pubmed
    ..Collectively, these studies indicate that glycosylphosphatidylinositol-anchored AGPs function to link the plasma membrane to the cytoskeleton. ..
  47. Singh I, Sidana J, Bansal P, Foley W. Phloroglucinol compounds of therapeutic interest: global patent and technology status. Expert Opin Ther Pat. 2009;19:847-66 pubmed publisher
    b>Phloroglucinol compounds, both synthetic as well as natural, have shown a vast array of biological activities...
  48. Li Z, Ma H, Lu H, Tao G. Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent. Talanta. 2008;74:788-92 pubmed publisher
    A spectrophotometric method for the determination of formaldehyde in foodstuffs was described by using phloroglucinol as the chromogenic agent...
  49. Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008;57:799-806 pubmed publisher
    ..Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo, thus providing a promising new strategy for the treatment of pancreatic tumours. ..
  50. Cabrelle A, Dell Aica I, Melchiori L, Carraro S, Brunetta E, Niero R, et al. Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease. J Leukoc Biol. 2008;83:212-9 pubmed
    ..Together, these properties qualify Hyp as a putative, therapeutic molecule for the treatment of autoimmune inflammatory disease sustained by Th1 cells, including EAE. ..
  51. Piao M, Zhang R, Lee N, Hyun J. Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator protein-1. Photochem Photobiol. 2012;88:381-8 pubmed publisher
    ..Recently, phloroglucinol (1,3,5-trihydroxybenzene) was demonstrated to attenuate the cell damage induced by oxidative stress by ..
  52. Moon C, Kim S, Kim J, Hyun J, Lee N, Park J, et al. Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice. Phytother Res. 2008;22:238-42 pubmed
    ..The radioprotective effects of two of the components of phlorotannin, phloroglucinol and eckol, in intestinal stem cells were examined by evaluating their effects on jejunal crypt survival and ..
  53. Dell Aica I, Niero R, Piazza F, Cabrelle A, Sartor L, Colalto C, et al. Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis. J Pharmacol Exp Ther. 2007;321:492-500 pubmed
    ..These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys. ..
  54. Kasajima N, Ito H, Hatano T, Yoshida T. Phloroglucinol diglycosides accompanying hydrolyzable tannins from Kunzea ambigua. Phytochemistry. 2008;69:3080-6 pubmed publisher
    Six phloroglucinol diglucosides-kunzeaphlogins A-F (1-6) and a hydrolyzable tannin, kunzeatannin A (7)-were isolated along with 10 known polyphenols from the leaf extract of Kunzea ambigua...