Summary: A phenolphthalein that is used as a diagnostic aid in hepatic function determination.

Top Publications

  1. Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, et al. Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17?-glucuronide, estrone-3-sulfate, and sulfobromophthalein. Drug Metab Dispos. 2013;41:1859-66 pubmed publisher
    ..of the prototypical substrates [³H]estradiol-17?-glucuronide (E?G), [³H]estrone-3-sulfate (E?S), and [³H]sulfobromophthalein (BSP) were studied in OATP1B1-transfected cells...
  2. Passamonti S, Cocolo A, Braidot E, Petrussa E, Peresson C, Medic N, et al. Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. FEBS J. 2005;272:3282-96 pubmed
    ..In conclusion, carnation petals express a homologue of rat liver bilitranslocase, with a putative function in the membrane transport of secondary metabolites. ..
  3. Reisman S, Csanaky I, Yeager R, Klaassen C. Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. Toxicol Sci. 2009;109:24-30 pubmed publisher
    b>Sulfobromophthalein (BSP) is used to study hepatobiliary excretory function. BSP is conjugated with glutathione (GSH), whereas its dibrominated analog disulfobromophthalein (DBSP) is not conjugated with GSH prior to biliary excretion...
  4. Kolobe D, Sayed Y, Dirr H. Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics. Biochem J. 2004;382:703-9 pubmed
    ..This would explain the non-competitive behaviour of certain inhibitors that bind the active site (e.g. BSP). ..
  5. Itoh T. [Pharmacokinetic study of cancer chemotherapy]. Yakugaku Zasshi. 2006;126:723-35 pubmed
    ..b>Sulfobromophthalein partially inhibited the secretion of SN-38-glucronide into the gastrointestinal lumen, whereas little ..
  6. Ito D, Molina H, Andriolo A, Borges D. The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone. Braz J Med Biol Res. 2007;40:343-8 pubmed
    ..Our results suggest that the combination of atorvastatin with ethanol is not more hepatotoxic than the separate use of each substance. ..
  7. Seithel A, Klein K, Zanger U, Fromm M, Konig J. Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C. Mol Genet Genomics. 2008;279:149-57 pubmed
    ..Uptake experiments with sulfobromophthalein, estradiol-17ssD-glucuronide, pravastatin, and taurocholic acid showed no significant difference in the ..
  8. Joachim A, Lautscham E, Christoffers J, Ruttkowski B. Oesophagostomum dentatum: effect of glutathione S-transferase (GST) inhibitors on GST activity and larval development. Exp Parasitol. 2011;127:762-7 pubmed publisher
    ..Differences between Od-GST and GST of other organisms indicate structural and possibly functional peculiarities and highlight the potential of such enzymes as targets of intervention. ..
  9. González M, Contini M, Millen N, Mahieu S. Role of melatonin in the oxidative damage prevention at different times of hepatic regeneration. Cell Biochem Funct. 2012;30:701-8 pubmed publisher

More Information

Publications105 found, 100 shown here

  1. Gyurasics A, Koszorus L, Varga F, Gregus Z. Increased biliary excretion of glutathione is generated by the glutathione-dependent hepatobiliary transport of antimony and bismuth. Biochem Pharmacol. 1992;44:1275-81 pubmed
    ..Diethyl maleate, indocyanine green and sulfobromophthalein (BSP), which decreased biliary excretion of GSH, significantly diminished excretion of antimony and bismuth ..
  2. Fernandes T, de Oliveira D, Suzuki Kemmelmeier F, Bracht A. Inhibition by extracellular ATP of organic anion transport in the perfused rat liver. Eur J Pharmacol. 2002;454:225-34 pubmed
    ..This reinforces the suggestion that inhibition of organic anion transport could be a physiologically relevant effect of extracellular ATP. ..
  3. Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf N, et al. The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug Metab Dispos. 2007;35:779-86 pubmed
    ..By using sulfobromophthalein (BSP) and the HMG-CoA reductase inhibitor pravastatin as substrates, the effects of the macrolides ..
  4. Szabo M, Veres Z, Baranyai Z, Jakab F, Jemnitz K. Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity. PLoS ONE. 2013;8:e59432 pubmed publisher
    ..In conclusion, we demonstrated that HepaRG cells may provide a suitable tool for hepatic uptake studies. ..
  5. Kurisu H, Kamisaka K, Koyo T, Yamasuge S, Igarashi H, Maezawa H, et al. Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia. Life Sci. 1991;49:1003-11 pubmed
    ..The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities. ..
  6. Rodriguez Garay E, Larocca C, Pisani G, del Luján Alvarez M, Rodriguez G. Adaptive hepatic changes in mild stenosis of the common bile duct in the rat. Res Exp Med (Berl). 1999;198:307-23 pubmed
    ..These findings may explain the limited hepatic and systemic repercussion of experimental mild stenosis of the common bile duct and help us to understand the early stages of constriction of the common bile duct in man. ..
  7. Vignesvaran K, Alias Z. PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3). Arch Insect Biochem Physiol. 2016;92:210-21 pubmed publisher
    ..1,2-dichloro-4-nitrobenzene, 2,4-hexadienal, 2,4-heptadienal, p-nitrobenzyl chloride, ethacrynic acid, and sulfobromophthalein. Therefore, it was evident that DmGSTD3 has made use of distal amino acids Y97 and Y89 for GSH conjugation. ..
  8. Alexander B, Rogers C, Naftalin R. Hepatic arterial perfusion decreases intrahepatic shunting and maintains glucose uptake in the rat liver. Pflugers Arch. 2002;444:291-8 pubmed
    ..The microsphere data indicate that confluence between the hepatic arterial and portal venous vasculatures occurs mainly in sinusoidal zone II. ..
  9. Segawa M, Ogura J, Seki S, Itagaki S, Takahashi N, Kobayashi M, et al. Rapid stimulating effect of the antiarrhythmic agent amiodarone on absorption of organic anion compounds. Drug Metab Pharmacokinet. 2013;28:178-86 pubmed
    ..AMD also increased the absorption of sulfobromophthalein (BSP), which is a typical organic anion compound, and the expression level of Oatp2b1 at the membrane in in ..
  10. Jager W, Gehring E, Hagenauer B, Aust S, Senderowicz A, Thalhammer T. Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2). Life Sci. 2003;73:2841-54 pubmed
    ..In summary, we found that FLAP glucuronides are substrates of Mrp2 effectively inhibiting the biliary excretion of bilirubin. This may explain the increased serum bilirubin levels observed in cancer patients during FLAP therapy...
  11. Itagaki S, Sumi Y, Shimamoto S, Itoh T, Hirano T, Takemoto I, et al. Secretory transport of irinotecan metabolite SN-38 across isolated intestinal tissue. Cancer Chemother Pharmacol. 2005;55:502-6 pubmed
    ..This secretory transport required metabolic energy and was diminished by sulfobromophthalein. However, mitoxantrone, an inhibitor of breast cancer resistance protein (BCRP), did not affect the ileal ..
  12. Han Y, Busler D, Hong Y, Tian Y, Chen C, Rodrigues A. Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters. Drug Metab Dispos. 2010;38:1072-82 pubmed publisher
    ..9 and K(m2) = 307 microM). Collectively, the data show that hepatic uptake of EE2-Sul can be mediated by three transporters (OATP1B1, OATP2B1, and NTCP), whereas biliary excretion of EE2-Sul into bile likely involves BCRP...
  13. Visentin M, Chang M, Romero M, Zhao R, Goldman I. Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Mol Pharmacol. 2012;81:134-42 pubmed publisher
    ..describes highly pH-dependent OATP2B1-mediated antifolate transport and compares this property with that of sulfobromophthalein (BSP), a preferred OATP2B1 substrate. At pH 5.5 and low substrate concentrations (~2...
  14. Engel A, Oswald S, Siegmund W, Keiser M. Pharmaceutical excipients influence the function of human uptake transporting proteins. Mol Pharm. 2012;9:2577-81 pubmed publisher
    ..However, the clinical relevance of these findings needs to be evaluated in further in vivo studies. ..
  15. Shieh C, Chang M, Chen C. Dubin-Johnson syndrome presenting with neonatal cholestasis. Arch Dis Child. 1990;65:898-9 pubmed
    ..Liver histology was studied during the neonatal period and at 6 years of age. Distinct brownish pigment granules in hepatocytes were noted. This case confirms that Dubin-Johnson syndrome is a cause of neonatal cholestasis. ..
  16. Millard P, Roth B, Thi H, Yue S, Haugland R. Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl Environ Microbiol. 1997;63:2897-905 pubmed
    ..Marked reduction in the formation of CIVS by ethacrynic acid and sulfobromophthalein, inhibitors of glutathione S-transferase, suggested that dye processing can involve enzyme-mediated ..
  17. Wang P, Kim R, Chowdhury J, Wolkoff A. The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport. J Biol Chem. 2003;278:20695-9 pubmed
    ..that cultured rat hepatocytes transported bilirubin with kinetics virtually identical to the transport of sulfobromophthalein. This assay was then used to quantify bilirubin transport by HeLa cells that had been stably transfected ..
  18. Hume R, Williamson J, Whitelaw J. Red cell survival in biliary cirrhosis. J Clin Pathol. 1970;23:397-401 pubmed
    ..It was concluded that the anaemia of cirrhosis of the liver, including primary biliary cirrhosis, may be due to a number of mechanisms and a unifying hypothesis based on the degree of liver dysfunction is suggested...
  19. Okudaira N, Komiya I, Sugiyama Y. Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine. J Pharmacol Exp Ther. 2000;295:717-23 pubmed
    ..The efflux transport of ME3277 was inhibited by 1-naphthol, 1-choloro-2,4-dinitrobenzene, and sulfobromophthalein, and efflux of ME3277 and monoacid metabolites from intestinal tissue preloaded with ME3229 fell in the ..
  20. Takayanagi M, Sano N, Takikawa H. Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat. J Gastroenterol Hepatol. 2005;20:784-8 pubmed
    ..The biliary excretion of olmesartan was inhibited by sulfobromophthalein, cefpiramide and pravastatin, but was not inhibited by taurocholate or tauroursodeoxycholate...
  21. Omer S, Meredith D, Morris J, Christian H. Evidence for the role of adenosine 5'-triphosphate-binding cassette (ABC)-A1 in the externalization of annexin 1 from pituitary folliculostellate cells and ABCA1-transfected cell models. Endocrinology. 2006;147:3219-27 pubmed
    ..The use of the ABCA1-transporter inhibitors geranyl-geranyl pyrophosphate and sulfobromophthalein significantly inhibited ANXA1 externalization...
  22. Cheng F, Wang Y, Li Z, Dong C. Fluorescence study on the interaction of human serum albumin with bromsulphalein. Spectrochim Acta A Mol Biomol Spectrosc. 2006;65:1144-7 pubmed
    ..All these experimental results and theoretical data clarified that BSP could bind to HSA and be effectively transported and eliminated in body, which could be a useful guideline for further drug design. ..
  23. Roth S, Kinne A, Schweizer U. The tricyclic antidepressant desipramine inhibits T3 import into primary neurons. Neurosci Lett. 2010;478:5-8 pubmed publisher
    ..Numerous interactions between thyroid hormones, depressive symptoms, and antidepressant treatments have been reported in the literature. Our findings add to the evidence that antidepressant drugs may affect CNS thyroid hormone function. ..
  24. Tichý J, Loucka M, Trefný Z. The new clearance method for hepatic diagnostics. Prague Med Rep. 2005;106:229-42 pubmed
    ..Clearance values enable to differentiate liver diseases and to add their clinical staging. Pathophysiology of dye kinetics is discussed from two points of view i.e. sinusoidal and canalicular membrane transfer. ..
  25. Yamaguchi H, Sugie M, Okada M, Mikkaichi T, Toyohara T, Abe T, et al. Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet. 2010;25:314-7 pubmed
    ..1)) In conclusion, we found that estrone 3-sulfate is a novel substrate for OATP4C1. Moreover, our results indicate that estrone 3-sulfate does not bind to the recognition site for digoxin in OATP4C1. ..
  26. Yanxiao C, Ruijuan X, Jin Y, Lei C, Qian W, Xuefen Y, et al. Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats. Life Sci. 2011;89:1-6 pubmed publisher
    ..We analyzed the effect of probenecid, cimetidine, sulfobromophthalein sodium (BSP), verapamil, inhibitors of organic anion transporter (OAT), organic cation transporter (OCT), ..
  27. Yao D, Liu L, Jin S, Li J, Liu X. Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats. Neuroscience. 2012;227:283-92 pubmed publisher
    ..The present study demonstrated that chronic PTZ-kindling increased Mrp2 expression and function in the rat brain, and the up-regulation partly came from epileptic seizure. ..
  28. Wang P, Hata S, Xiao Y, Murray J, Wolkoff A. Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1052-9 pubmed publisher
    ..This was in accord with the finding that fully unglycosylated oatp1a1 was well expressed but located intracellularly with limited transport ability as a consequence of its reduced cell surface expression. ..
  29. Nunes R, Kiang C, Sorrentino D, Berk P. 'Albumin-receptor' uptake kinetics do not require an intact lobular architecture and are not specific for albumin. J Hepatol. 1988;7:293-304 pubmed
    ..well-stirred single cell suspensions of rat hepatocytes were incubated with 5-600 microM [3H]oleate or [35S]sulfobromophthalein (BSP) in the presence of 150 microM bovine serum albumin (BSA), uptake of both ligands increased as a ..
  30. Vavricka S, Van Montfoort J, Ha H, Meier P, Fattinger K. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002;36:164-72 pubmed
    The antibiotics rifamycin SV and rifampicin substantially reduce sulfobromophthalein (BSP) elimination in humans...
  31. Serrano M, Bayon J, Pascolo L, Tiribelli C, Ostrow J, Gonzalez Gallego J, et al. Evidence for carrier-mediated transport of unconjugated bilirubin across plasma membrane vesicles from human placental trophoblast. Placenta. 2002;23:527-35 pubmed
    ..These findings suggest the presence of distinct transporters in the two domains of human placental trophoblast that could cooperate to transfer UCB from the foetus to the maternal circulation. ..
  32. Tanaka H, Sano N, Takikawa H. Biliary excretion of phenolphthalein sulfate in rats. Pharmacology. 2003;68:177-82 pubmed
    ..The biliary excretion of leukotriene C(4) metabolites and sulfobromophthalein was inhibited by phenolphthalein sulfate infusion to some extent...
  33. Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T. Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury. Biol Pharm Bull. 2007;30:556-61 pubmed
  34. Chiba M, Itagaki S, Kobayashi M, Hirano T, Iseki K. Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats. Drug Metab Pharmacokinet. 2007;22:450-5 pubmed
    ..We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased...
  35. Hagenbuch N, Reichel C, Stieger B, Cattori V, Fattinger K, Landmann L, et al. Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J Hepatol. 2001;34:881-7 pubmed
    ..The hepatic clearance of drugs and cholephilic organic anions is stimulated by phenobarbital (PB). Our aim was to analyze the effects of PB on the expression of hepatocellular bile salt and organic anion transporters...
  36. Wang P, Boccanfuso M, Lemay A, Devries H, Sui J, She Y, et al. Sex-specific extraction of organic anions by the rat liver. Life Sci. 2008;82:436-43 pubmed publisher
    ..Our results suggest that differences in sinusoidal uptake are responsible for the sex-specific hepatic excretion of some organic anions. ..
  37. Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiyama Y, et al. The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Drug Metab Pharmacokinet. 2010;25:274-82 pubmed
    ..Pravastatin uptake into INS-1e cells was detected and this transport was inhibited by sulfobromophthalein and rifampicin, both of which are known to inhibit oatp family-mediated uptake...
  38. Ockner R, Manning J, Poppenhausen R, Ho W. A binding protein for fatty acids in cytosol of intestinal mucosa, liver, myocardium, and other tissues. Science. 1972;177:56-8 pubmed
    ..Binding of long-chain fatty acids by this protein is greater than that of other anions tested, including sulfobromophthalein, and does not depend on negative charge alone...
  39. Kullak Ublick G, Ismair M, Stieger B, Landmann L, Huber R, Pizzagalli F, et al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001;120:525-33 pubmed
    ..OATP-B, OATP-C, and OATP8 account for the major part of sodium-independent bile salt, organic anion, and drug clearance of human liver. ..
  40. Tazuma S, Horikawa K, Ochi H, Nishioka T, Sunami Y, Yasumiba S, et al. Dose-dependent conjugation of sulfobromophthalein and hepatic transit time in bile fistula rats: role of the microtubule-dependent vesicle pathway. Dig Dis Sci. 2001;46:1285-9 pubmed
    b>Sulfobromophthalein (BSP) is selectively taken up by the liver and secreted into the bile as unconjugated and conjugated forms...
  41. Sweet D, Miller D, Pritchard J, Fujiwara Y, Beier D, Nigam S. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002;277:26934-43 pubmed
    ..These data indicate a key role for Oat3 in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid. ..
  42. Itoh T, Itagaki S, Sasaki K, Hirano T, Takemoto I, Iseki K. Pharmacokinetic modulation of irinotecan metabolites by sulphobromophthalein in rats. J Pharm Pharmacol. 2004;56:809-12 pubmed
    ..These results suggested that cotreatment of CPT-11 with sulphobromophthalein might decrease intraluminal SN-38 concentrations without altering the pharmacokinetics of SN-38. ..
  43. Fretzayas A, Kitsiou S, Papadopoulou A, Nicolaidou P. Clinical expression of co-inherited Dubin-Johnson and thalassaemic heterozygous states. Dig Liver Dis. 2007;39:369-74 pubmed
    ..We report the first family with modified clinical expression of Dubin-Johnson heterozygous state due to genotypic interaction with co-inherited beta and deltabeta thalassaemia, an interaction that has never been described. ..
  44. Wang R, Hao H, Wang G, Xie H, Xu M, Wang W, et al. Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether. J Photochem Photobiol B. 2008;90:179-86 pubmed publisher
    ..In conclusion, this study provided firstly the full pharmacokinetic characteristics and mechanisms of deuxemether, which would be helpful for its clinical regiment design. ..
  45. Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, et al. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology. 1991;14:352-60 pubmed
    ..Biliary excretion of sulfobromophthalein was markedly impaired and almost no glutathione conjugate was excreted in the bile of the Eisai ..
  46. Hoener B, Tzika A, Englestad B, White D. Hepatic transport of the magnetic resonance imaging contrast agent Fe(III)-N-(3-phenylglutaryl)desferrioxamine B. Magn Reson Med. 1991;17:509-15 pubmed
    ..These results suggested that uptake of Fe-PGDF by the hepatocytes occurred via the BSP transporter and that no enterohepatic recycling of the contrast agent occurred...
  47. Kitamura T, Jansen P, Hardenbrook C, Kamimoto Y, Gatmaitan Z, Arias I. Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci U S A. 1990;87:3557-61 pubmed
    ..The defect in TR- mutant rats is phenotypically similar to that seen in mutant Corriedale sheep and in the Dubin-Johnson syndrome in man. ..
  48. Passamonti S, Battiston L, Sottocasa G. On the mechanism of bilitranslocase transport inactivation by phenylmethylsulphonyl fluoride. Mol Membr Biol. 1999;16:167-72 pubmed
    ..Also, in this study, the PMSF-modified serine(s) is shown to be involved in bilirubin binding by bilitranslocase. ..
  49. Honscha W, Petzinger E. Characterization of the bile acid sensitive methotrexate carrier of rat liver cells. Naunyn Schmiedebergs Arch Pharmacol. 1999;359:411-9 pubmed
    ..The carrier differs from previously described transporters for the uptake of organic anions. ..
  50. Yang B, Hill C. Nifedipine modulation of biliary GSH and GSSG/ conjugate efflux in normal and regenerating rat liver. Am J Physiol Gastrointest Liver Physiol. 2001;281:G85-94 pubmed
    ..Glutathione, but not BSP, efflux capacity was reduced following partial hepatectomy. We suggest GSH efflux is mediated by a high-capacity organic anion pathway capable of GSSG transport when its high-affinity route is saturated. ..
  51. Kato Y, Kuge K, Kusuhara H, Meier P, Sugiyama Y. Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther. 2002;302:483-9 pubmed
  52. Wang P, Wang J, Xiao Y, Murray J, Novikoff P, Angeletti R, et al. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem. 2005;280:30143-9 pubmed
    ..Plasma disappearance of the Oatp1a1 ligand [35S]sulfobromophthalein was correspondingly delayed in knock-out mice...
  53. Glaeser H, Mandery K, Sticht H, Fromm M, Konig J. Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010;159:698-708 pubmed publisher
    ..We demonstrated that the conserved positively charged amino acids Lys41 and Arg580 are pivotal to the transport activity of OATP1B3. ..
  54. Kiroğlu O, Aydinoglu F, Ogulener N. The effects of thiol modulators on nitrergic nerve- and S-nitrosothiols-induced relaxation in duodenum. J Basic Clin Physiol Pharmacol. 2013;24:143-50 pubmed publisher
    ..the effects of buthionine sulfoximine (100 ?M), an inhibitor of ?-glutamylcysteine synthetase, and sulfobromophthalein (100 ?M), an inhibitor of glutathione-S-transferase, were studied on relaxant responses to EFS and S-..
  55. Imaoka T, Mikkaichi T, Abe K, Hirouchi M, Okudaira N, Izumi T. Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor. Drug Metab Dispos. 2013;41:1442-9 pubmed publisher
  56. Hosokawa S, Tagaya O, Mikami T, Nozaki Y, Kawaguchi A, Yamatsu K, et al. A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Lab Anim Sci. 1992;42:27-34 pubmed
    ..The spontaneous hyperbilirubinuric rat (EHBR) may be a useful animal model for studying constitutive conjugated hyperbilirubinemia, bilirubin metabolism, cholestasis, and glomerulonephropathy subsequent to hepatic dysfunction. ..
  57. Gentile S, Persico M, Tiribelli C. Abnormal hepatic uptake of low doses of sulfobromophthalein in Gilbert's syndrome: the role of reduced affinity of the plasma membrane carrier of organic anions. Hepatology. 1990;12:213-7 pubmed
    The plasma disappearance rate of sulfobromophthalein (VBSP; mumol/kg/min) was measured in 15 Gilbert's syndrome patients and 12 control subjects after intravenous injection of two different doses (0.59 and 5.90 mumol/kg) of the dye...
  58. Milne R, Larsen L, Jørgensen K, Bastlund J, Stretch G, Evans A. Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein. Pharm Res. 2000;17:1511-5 pubmed
    ..Erythromycin reduced the canalicular transport of fexofenadine into bile, whereas DBSP reduced uptake across the sinusoidal membrane. ..
  59. Pettigrew N, Brush E, Colman R. 3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38. Biochemistry. 2001;40:7549-58 pubmed
    ..These results show that MOI reacts preferentially with GST pi. Such a compound may be useful in novel combination chemotherapy to enhance the efficacy of alkylating cancer drugs while minimizing toxic side effects. ..
  60. Sangsritavong S, Combs D, Sartori R, Armentano L, Wiltbank M. High feed intake increases liver blood flow and metabolism of progesterone and estradiol-17beta in dairy cattle. J Dairy Sci. 2002;85:2831-42 pubmed
    ..Higher rates of LBF and steroid metabolism in lactating than in nonlactating cows may indicate chronic effects of higher feed intakes as well. ..
  61. Pastor C, Planchamp C, Pochon S, Lorusso V, Montet X, Mayer J, et al. Kinetics of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation. Radiology. 2003;229:119-25 pubmed
    ..Measurements of gadolinium concentrations in hepatic tissues confirmed these findings. In the liver, the hepatospecific contrast agent Gd-BOPTA enters into hepatocytes likely through the organic anion transporting peptide 1. ..
  62. Hanawa N, Sano N, Takikawa H. Biliary excretion of azelnidipine, a calcium antagonist, in rats. J Gastroenterol Hepatol. 2004;19:413-7 pubmed
    ..Furthermore, the effect of sulfobromophthalein, taurocholate and vinblastine on the biliary excretion of azelnidipine metabolites was also studied in ..
  63. Steiner C, Sen S, Stange J, Williams R, Jalan R. Binding of bilirubin and bromosulphthalein to albumin: implications for understanding the pathophysiology of liver failure and its management. Liver Transpl. 2004;10:1531-8 pubmed
    ..C(bilirubin)/C(alb) appears to be important in albumin dialysis, and generally in liver disease patients, reinforcing the importance of the toxin-binding functions of albumin in liver disease. ..
  64. Yao H, Chiou W. The complexity of intestinal absorption and exsorption of digoxin in rats. Int J Pharm. 2006;322:79-86 pubmed
    ..Our study may have clinical implications in drug-drug or drug-food interactions involving transporters. ..
  65. Gui C, Hagenbuch B. Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comp Biochem Physiol C Toxicol Pharmacol. 2010;151:393-9 pubmed publisher
    ..In conclusion, the cloned canine Oatp1b4 will provide additional molecular basis to further characterize the species difference of the OATP1B family members. ..
  66. Ueno Y, Matsuda H, Mizutani H, Iwamoto T, Okuda M. Involvement of specific transport system on uptake of lactone form of SN-38 in human intestinal epithelial cell line Caco-2. Biol Pharm Bull. 2012;35:54-8 pubmed
    ..The type of inhibition by baicalin was competitive. In contrast, concomitant sulfobromophthalein, taurocholate and estrone 3-sulfate significantly increased SN-38L uptake...
  67. Salvemini D, Pistelli A, Vane J. Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. Br J Pharmacol. 1993;108:162-9 pubmed
    ..This decrease in NO formation shows that tolerance to GTN is mainly due to impaired biotransformation of GTN to NO. NAC, by directly forming NO from GTN, compensates for this failing mechanism. ..
  68. Soto A, Foy B, Frazier J. Effect of cadmium on bromosulfophthalein kinetics in the isolated perfused rat liver system. Toxicol Sci. 2002;69:460-9 pubmed
    ..Taken together, the data indicate that Cd has a significant effect on the kinetics of BSP in the IPRL and the dominant effects were mediated through the cholestatic effect of Cd. ..
  69. Hirouchi M, Suzuki H, Sugiyama Y. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Pharm Res. 2005;22:661-6 pubmed
    ..In addition, the plasma direct bilirubin level in EHBR was reduced by the expression of human MRP2. These results suggest that this evaluation system for human MRP2 may be useful for evaluating the function of human MRP2. ..
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    ..Furthermore, NAFLD may alter the plasma retention time of clinically relevant drugs that are reliant on these transporters and may increase the potential drug toxicity. ..
  72. Maestro A, Terdoslavich M, Vanzo A, Kuku A, Tramer F, Nicolin V, et al. Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter. Cardiovasc Res. 2010;85:175-83 pubmed publisher
    ..The uptake of some flavonoids into the vascular endothelium occurs via the bilirubin-specific membrane transporter bilitranslocase. This offers new insights into the vascular effects of both flavonoids and bilirubin. ..
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    ..In conclusion, these in vitro results demonstrate that several oral antidiabetic drugs may influence hepatic OATP-mediated drug uptake. The in vivo consequences of these results have to be analysed in further studies. ..
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    ..Moreover this data indicate the value of precision-cut liver slices for phenotypic drug uptake studies. ..
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    Both inactivation of sulfobromophthalein transport in rat liver plasma membrane vesicles by sulfhydryl group reagents and subsequent reactivation by 2-mercaptoethanol are shown to be modulated by ligands to bilitranslocase...
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    ..It would appear that a reduction in the biliary excretion of BSP cannot be taken to be an indication of reduced liver function in a general sense. ..
  79. Becq F, Hamon Y, Bajetto A, Gola M, Verrier B, Chimini G. ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes. J Biol Chem. 1997;272:2695-9 pubmed
    ..We report here that ABC1 generates an anion flux sensitive to glibenclamide, sulfobromophthalein, and blockers of anion transporters...
  80. Johnson D, Klaassen C. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicol Appl Pharmacol. 2002;180:56-63 pubmed
    ..This study also demonstrates the importance of compensatory hepatic transporters in eliminating DBSP by alternative pathways other than Mrp2. ..
  81. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier P. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002;16:2283-96 pubmed
    ..Thus, in contrast to most other family members, OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. ..
  82. Ninomiya M, Ito K, Hiramatsu R, Horie T. Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2). Drug Metab Dispos. 2006;34:2056-63 pubmed
    ..This is due not only to the difference in the Km and Vmax values, but also the qualitatively different mode of substrate and modulator recognition exhibited by different species. ..
  83. Bertolini A, Peresson C, Petrussa E, Braidot E, Passamonti S, Macri F, et al. Identification and localization of the bilitranslocase homologue in white grape berries (Vitis vinifera L.) during ripening. J Exp Bot. 2009;60:3861-71 pubmed publisher
    ..Such results strengthen the hypothesis that this BTL homologue acts as a carrier involved also in the membrane transport of colourless flavonoids and demonstrate the presence of such a carrier in different organs and tissues. ..
  84. Takano M, Otani Y, Tanda M, Kawami M, Nagai J, Yumoto R. Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2. Drug Metab Pharmacokinet. 2009;24:418-27 pubmed
    ..Probenecid, an MRP inhibitor, did not affect [(3)H]paclitaxel uptake in both cells. Sulfobromophthalein, an OATP1B3 inhibitor, inhibited [(3)H]paclitaxel uptake in HepG2 but not in PR-HepG2 cells...
  85. Catala A, Zanneti R. Leakage of sulphobromophthalein from large simple bilayer phospholipid vesicles. J Microencapsul. 1988;5:319-24 pubmed
    ..These vesicles incorporated up to one molecule of oleic acid for each two and a half molecules of egg lecithin, and appear to be suitable as acceptors in studies of fatty acid transfer between membranes. ..
  86. Li Q, Briggs M, Folkens D, Hill C. Models of depressed hepatic mrp2 activity reveal bromosulphophthalein-sensitive passive K+ flux. Can J Physiol Pharmacol. 2002;80:1167-72 pubmed
    ..The results demonstrate that BSP stimulates basolateral (sinusoidal) K+ channels independently of its canalicular excretion, revealing an early event in BAIF and suggesting that Kir4.2 may mediate BSP-sensitive K+ flux. ..
  87. Torres A, MacLaughlin M, Quaglia N, Stremmel W. Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney. Mol Cell Biochem. 2003;245:149-56 pubmed
    ..Western blot studies revealed positivity to antiBBBP antibodies in both BBMV and BLMV. So BBBP is also expressed in the kidneys and accounts, at least in part, for the renal tubular transport of PAH. ..
  88. Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, et al. Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003;285:G829-39 pubmed
    ..Ntcp mediated high affinity, sodium-dependent transport of [35S]sulfobromophthalein with a Km similar to that of oatp1-mediated transport of [35S]sulfobromophthalein (Km = 3.7 vs. 3...
  89. Han X, Yang C, Snajdr S, Nabb D, Mingoia R. Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats. Toxicol Lett. 2008;181:81-6 pubmed publisher
    ..The active uptake of PFO in rat hepatocytes was inhibited by sulfobromophthalein, a known substrate of organic anion transporting polypeptides, with apparent inhibition constants of 85...
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    ..Furthermore, they suggest the conscious rat model does not offer methodological advantage and the anesthesia model is suitable for a realistic approximation of the hepatobiliary transport of BSP. ..
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    ..In the present study, we examined the inhibitory effect of CsA on the hepatic uptake of sulfobromophthalein (BSP) in rats, focusing on a long-lasting inhibition...
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    b>Sulfobromophthalein (BSP) electrogenic transport activity in a plasma membrane vesicle preparation from rat liver is shown to depend on free sulfhydryl groups...