phenetidine

Summary

Summary: Used in the manufacture of acetophenetidin.

Top Publications

  1. Jensen C, Jollow D. The role of N-hydroxyphenetidine in phenacetin-induced hemolytic anemia. Toxicol Appl Pharmacol. 1991;111:1-12 pubmed
    ..As measured by decreased survival of 51Cr-labeled erythrocytes in rats, phenacetin, p-phenetidine, and PNOH were all hemolytic in vivo, with PNOH being significantly the most potent of the three...
  2. Kuek A, Hazleman B, Ostor A. Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution. Postgrad Med J. 2007;83:251-60 pubmed
    ..For the medical profession, IMID represents a breakthrough in the way pathology is classified. In this burgeoning era of biologic therapy the prospect of complete disease remission is conceivable...
  3. Gulkowska A, Krauss M, Rentsch D, Hollender J. Reactions of a sulfonamide antimicrobial with model humic constituents: assessing pathways and stability of covalent bonding. Environ Sci Technol. 2012;46:2102-11 pubmed publisher
    ..These processes could also hold true for soils, and a slow nonextractable residue formation with time could be related to a slow increase of the amount of covalently bound sulfonamide and the strength of bonding...
  4. Lindqvist T, Moldeus P, Lindeke B. Cellular effects of some metabolic oxidation products pertinent to 4-ethoxyaniline. Pharmacol Toxicol. 1991;69:117-21 pubmed
    ..No superoxide dismutase inhibitable reduction of acetylated cytochrome c was observed, thus none of the compounds undergoes measurable redox cycling...
  5. Lindqvist T, Kenne L, Lindeke B. On the chemistry of the reaction between N-acetylcysteine and 4-[(4-ethoxyphenyl)imino]-2,5-cyclohexadien-1-one, a 4-ethoxyaniline metabolite formed during peroxidase reactions. Chem Res Toxicol. 1991;4:489-96 pubmed
    4-Ethoxyaniline (p-phenetidine) is oxidized by peroxidases to form several products, one of which is 4-[(4-ethoxyphenyl)imino]-2,5-cyclohexadien-1-one (1)...
  6. Rachtan R, Starek A. [Antipyretic action of aniline derivatives in rats during different parts of the day]. Folia Med Cracov. 1990;31:289-302 pubmed
    ..The aim of the experiments was to evaluate the antipyretic action of phenacetin, p-phenetidine and acetaminophen in rats administered at different periods of day...
  7. Togei K, Sano N, Maeda T, Shibata M, Otsuka H. Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice. J Natl Cancer Inst. 1987;79:1151-8 pubmed
    ..Papilloma of the urinary bladder in 1 male mouse and papillary or nodular hyperplasia in 9 mice of both sexes were observed in groups given the high dose of bucetin...
  8. Imai K, Fukushima T, Yokosu H. A novel electrophilic reagent, 4-(N-chloroformylmethyl-N-methyl)amino- 7-N,N-dimethylaminosulphonyl-2,1,3-benzoxadiazole (DBD-COCl) for fluorometric detection of alcohols, phenols, amines and thiols. Biomed Chromatogr. 1994;8:107-13 pubmed
    ..of hydroxyls), (-)-mandelic and D,L-lactic acid (hydroxy acid), estrone (phenol), benzylamine (primary amine), phenetidine (aromatic amine) and alpha-mercapto-N,2-naphthylacetamide (thiol) to give fluorescent products bearing ..
  9. Pauluhn J, Mohr U. Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats. Inhal Toxicol. 2001;13:993-1013 pubmed
    ..and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882...

More Information

Publications12

  1. Kankuri E, Solatunturi E, Vapaatalo H. Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro. Thromb Res. 2003;110:299-303 pubmed
    ..the possible cyclooxygenase (COX)-1/COX-2 selectivity of the old analgesic drug phenacetin and its metabolite p-phenetidine, which exhibits high renal toxicity...
  2. Wood D, Davies S, Cummins A, Button J, Holt D, Ramsey J, et al. Energy-1 ('NRG-1'): don't believe what the newspapers say about it being legal. Emerg Med J. 2011;28:1068-70 pubmed publisher
    ..Future educational campaigns aimed at recreational drug and legal high users should include reference to the potential legal implications of buying these substances...
  3. Kobayashi Y, Fukami T, Higuchi R, Nakajima M, Yokoi T. Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. Biochem Pharmacol. 2012;84:1196-206 pubmed publisher
    ..a general esterase inhibitor, was found to decrease the levels of Met-Hb and the plasma concentration of p-phenetidine, a hydrolyzed metabolite of phenacetin...