dicofol

Summary

Summary: An organochlorine insecticide.

Top Publications

  1. Dogheim S, El Marsafy A, Salama E, Gadalla S, Nabil Y. Monitoring of pesticide residues in Egyptian fruits and vegetables during 1997. Food Addit Contam. 2002;19:1015-27 pubmed
    ..b>Dicofol and dimethoate were the most frequently occurring pesticide residues at 5.1 and 5.0%, respectively...
  2. Li Q, Zhang H, Luo Y, Song J, Wu L, Ma J. Residues of DDTs and their spatial distribution characteristics in soils from the Yangtze River Delta, China. Environ Toxicol Chem. 2008;27:24-30 pubmed
    ..The computed ratios implied that the source of DDT might be related to the application of dicofol, an acaricide manufactured from technical DDTs and mainly used on cotton fields to treat mites.
  3. Thiel A, Guth S, Böhm S, Eisenbrand G. Dicofol degradation to p,p'-dichlorobenzophenone - a potential antiandrogen. Toxicology. 2011;282:88-93 pubmed publisher
    In the present investigation, the degradation of the acaricide dicofol (also known as kelthane) was investigated with special emphasis on generation of p,p'-dichlorobenzophenone (DCBP) under alkaline conditions as well as induced by UV-..
  4. Fujii Y, Haraguchi K, Harada K, Hitomi T, Inoue K, Itoh Y, et al. Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan. Chemosphere. 2011;82:25-31 pubmed publisher
    ..To investigate dicofol as a possible source of the DDTs in human breast milk, we collected breast milk samples from 2007 to 2009 in ..
  5. Han S, Qiao J, Zhang Y, Yang L, Lian H, Ge X, et al. Determination of n-octanol/water partition coefficient for DDT-related compounds by RP-HPLC with a novel dual-point retention time correction. Chemosphere. 2011;83:131-6 pubmed publisher
    n-Octanol/water partition coefficients (P) for DDTs and dicofol were determined by reversed-phase high performance liquid chromatography (RP-HPLC) on a C(18) column using methanol-water mixture as mobile phase...
  6. Qiu X, Zhu T, Yao B, Hu J, Hu S. Contribution of dicofol to the current DDT pollution in China. Environ Sci Technol. 2005;39:4385-90 pubmed
    ..ratios observed in the air over Taihu Lake, a lake near Shanghai, China, led us to suggest that current use of dicofol in the area north of the lake was the main source of the measured DDTs...
  7. Chan W, Liao J, Chou C, Chan P, Wei C, Ueng T. Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009;190:150-5 pubmed publisher
    The present study has determined the ability of dicofol, an organochlorine pesticide, to induce cytochrome P450 using rats treated with 1, 10, and 25mg/kg dicofol intraperitoneally for 4 days...
  8. Hoekstra P, Burnison B, Garrison A, Neheli T, Muir D. Estrogenic activity of dicofol with the human estrogen receptor: Isomer- and enantiomer-specific implications. Chemosphere. 2006;64:174-7 pubmed
    b>Dicofol is a non-systemic acaricide/miticide currently registered in the US and Canada for use on a wide variety of crops...
  9. Wang H, Yan H, Qiu M, Qiao J, Yang G. Determination of dicofol in aquatic products using molecularly imprinted solid-phase extraction coupled with GC-ECD detection. Talanta. 2011;85:2100-5 pubmed publisher
    ..The obtained MIM exhibited good recognition and selectivity to dicofol and it was successfully applied as selective sorbent of solid-phase extraction for the determination of dicofol ..

More Information

Publications62

  1. Weaver T, Ghadiri H, Hulugalle N, Harden S. Organochlorine pesticides in soil under irrigated cotton farming systems in Vertisols of the Namoi Valley, north-western New South Wales, Australia. Chemosphere. 2012;88:336-43 pubmed publisher
    ..b>Dicofol and Dieldrin, two OCPs previously undocumented in Vertisols were also detected...
  2. Haeba M, Hilscherova K, Mazurová E, Blaha L. Selected endocrine disrupting compounds (vinclozolin, flutamide, ketoconazole and dicofol): effects on survival, occurrence of males, growth, molting and reproduction of Daphnia magna. Environ Sci Pollut Res Int. 2008;15:222-7 pubmed
    ..We have studied effects of four model EDCs (vinclozolin, flutamide, ketoconazole and dicofol) on D...
  3. Guo Y, Yu H, Zeng E. Occurrence, source diagnosis, and biological effect assessment of DDT and its metabolites in various environmental compartments of the Pearl River Delta, South China: a review. Environ Pollut. 2009;157:1753-63 pubmed publisher
    ..There is evidence that new point sources, such as dicofol and anti-fouling paint, may have contributed DDTs to various environmental compartments...
  4. Brown M, Casida J. Metabolism of a dicofol impurity alpha-chloro-DDT, but not dicofol or dechlorodicofol, to DDE in mice and a liver microsomal system. Xenobiotica. 1987;17:1169-74 pubmed
    1. The important acaricide dicofol and two related compounds, alpha-chloro-DDT (an impurity in dicofol) and dechlorodicofol (DCD) (a photolysis product of dicofol), as [phenyl-14C]-labelled preparations, were administered i.p...
  5. Perobelli J, Martinez M, da Silva Franchi C, Fernandez C, de Camargo J, Kempinas W. Decreased sperm motility in rats orally exposed to single or mixed pesticides. J Toxicol Environ Health A. 2010;73:991-1002 pubmed publisher
    ..adverse health effects of low-level exposure to agrochemicals, the reproductive toxicity of the pesticides dicofol, dichlorvos, permethrin, endosulfan, and dieldrin was evaluated in rats dosed with these chemicals individually ..
  6. Mourer C, Hall G, Whitehead W, Shibamoto T, Shull L, Schwarzbach S. Chromatographic determination of dicofol and metabolites in egg yolks. Arch Environ Contam Toxicol. 1990;19:154-6 pubmed
    Egg yolk was spiked with p,p'-dicofol (p,p'-DCF) (0.1-2.0 micrograms/gm), p,p'-dichlorobenzophenone (p,p'-DCBP) (0.1-2.0 micrograms/gm), and 1,1-bis(4-chlorophenyl)-2,2-dichloroethylene (p,p'-DDE) (0.05-1.0 micrograms/gm)...
  7. Zhang J, Yan H, Yang T, Zong Y. Removal of dicofol from water by immobilized cellulase and its reaction kinetics. J Environ Manage. 2011;92:53-8 pubmed publisher
    Researches on the removal of dicofol catalyzed by immobilized cellulase were conducted. Factors, such as acidity, temperature, enzyme activity, and initial concentration of dicofol, which could influence the removal were studied...
  8. Kamata R, Shiraishi F, Nakajima D, Takahashi S, Shimizu A. Evaluation of the impact of in-ovo exposure to dicofol on avian reproduction. Environ Toxicol Chem. 2010;29:2316-22 pubmed publisher
    To assess the possible impact of the currently used organochlorine insecticide, dicofol, on the development and reproduction of avian species, in ovo exposure experiments to its p,p' and o,p' isomers were performed using Japanese quail (..
  9. Turgut C, Gokbulut C, Cutright T. Contents and sources of DDT impurities in dicofol formulations in Turkey. Environ Sci Pollut Res Int. 2009;16:214-7 pubmed publisher
    b>Dicofol is widely used as a pesticide in agriculture applications. Since dicofol is mainly synthesized from dichlorodiphenyltrichlorethane (DDT), it contains DDT as an impurity...
  10. Saha K, Saha T, Banerjee H, Bhattacharyya A, Chowdhury A, Somchoudhury A. Persistence of dicofol residue on tea under North-East Indian climatic conditions. Bull Environ Contam Toxicol. 2004;73:347-50 pubmed
  11. Ho T, Fauziah M, Saleh I. Laboratory evaluation of five pesticides for control of Leptotrombidium fletcheri (Acari: Trombiculidae). Southeast Asian J Trop Med Public Health. 1992;23:125-7 pubmed
    ..6 ppm, LC99 = 18.2 ppm), bromopropylate (LC50 = 9.2 ppm, LC99 = 239.6 ppm), dicofol (LC50 = 27.8 ppm, LC99 = 118.1 ppm), fenthion (LC50 = 15.4 ppm, LC99 = 29.7 ppm), and malathion (LC50 = 84...
  12. Surendranath P, Rao K. Kelthane residues in tissues of the tropical penaeid prawn, Metapenaeus monoceros (Fabricius), under sublethal chronic exposure--a monitoring study. J Appl Toxicol. 1991;11:219-22 pubmed
    ..This confirms that kelthane is a persistent insecticide of low biodegradability and capable of accumulating in tissues as residues even at sublethal concentration under chronic exposure. ..
  13. Lessenger J, Riley N. Neurotoxicities and behavioral changes in a 12-year-old male exposed to dicofol, an organochloride pesticide. J Toxicol Environ Health. 1991;33:255-61 pubmed
    The case of a 12-yr-old male exposed to a substantial amount of dicofol, a DDT analog, is presented. The patient was still contaminated 3 wk after exposure. Blood and fat analysis documented the presence of dicofol...
  14. Sato A, Abe K, Yuzuriha M, Fujii S, Takahashi N, Hojo H, et al. A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats. Mutat Res. 2014;762:17-23 pubmed publisher
    ..749-1G>T/+ heterozygotes having externally undetectable thyroidal lesions. ..
  15. Ribeiro M, Amador J, Polese L, Jardim E, Minelli E, de Cordis O. Effect of a pilot washing system on dicofol levels in orange matrix. J Agric Food Chem. 2000;48:2818-20 pubmed
    An efficient analytical method is described for the analysis of dicofol residues in pulp and orange peel. Samples are mixed with Celite and transferred to chromatographic columns prepacked with silica gel...
  16. Yan H, Cheng X, Sun N. Synthesis of multi-core-shell magnetic molecularly imprinted microspheres for rapid recognition of dicofol in tea. J Agric Food Chem. 2013;61:2896-901 pubmed publisher
    ..as the dummy template and were successfully used as a specific adsorbent for rapid isolation of trace levels of dicofol from teas...
  17. Gudleifsson B, Hallas T, Olafsson S, Sveinsson T. Chemical control of Penthaleus major (Acari: Prostigmata) in hayfields in Iceland. J Econ Entomol. 2002;95:307-12 pubmed
    ..A side effect of application was a small but significant reduction in potassium-content of the yield, and the reduction in mite population was accompanied by a corresponding reduction in the number of spiders. ..
  18. Park Y, Yoon C, Kim J, Park J, Cheong S. Numerical variations and spontaneous malformations in the early embryos of the Korean salamander, Hynobius leechii, in the farmlands of Korea. Environ Toxicol. 2010;25:533-44 pubmed publisher
    ..These results indicate that various agricultural chemicals and other unknown factors may cause the aforementioned forms of spontaneous malformations in the embryos of Hynobius leechii. ..
  19. Reddy G. Comparative effectiveness of an integrated pest management system and other control tactics for managing the spider mite Tetranychus ludeni (Acari: Tetranychidae) on eggplant. Exp Appl Acarol. 2001;25:985-92 pubmed
    ..neem oil), the standard (susceptible) eggplant variety (MDU1) grown by farmers and treated with an acaricide (dicofol) had significantly higher mite densities. The predator C...
  20. Zhu M, Wang Y. [Determination of dicofol residue in tea by wide-bore capillary gas chromatographic column]. Se Pu. 2000;18:64-6 pubmed
    b>Dicofol residue is harmful to health. More and more countries have established the limitation of dicofol in foods. This paper describes an efficient method of determination for the dicofol residue in tea...
  21. Shimada N, Yamauchi K. Characteristics of 3,5,3'-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response. J Endocrinol. 2004;183:627-37 pubmed
    ..Among the test chemicals, di-n-butyl phthalate, n-butylbenzyl phthalate and the miticide, dicofol, were the most powerful inhibitors of [125I]T3 uptake, with an IC50 of 2...
  22. El Shahawi M. Retention profiles of some commercial pesticides, pyrethroid and acaricide residues and their application to tomato and parsley plants. J Chromatogr A. 1997;760:179-92 pubmed
    ..Analysis of N, P, Na, K, Cu, Zn, Mn, Fe, humidity, wet and dry mass of tomato and parsley untreated and sprayed for different time intervals--i.e. 24, 72 and 120 h--with Chlorpyrifos, was carried out. ..
  23. Seenivasan S, Muraleedharan N. Survey on the pesticide residues in tea in south India. Environ Monit Assess. 2011;176:365-71 pubmed publisher
    ..of three years from 2006 to 2008 and 912 tea samples were analysed for the residues of certain pesticides such as dicofol, ethion, quinalphos, hexaconazole, fenpropathrin, fenvalerate and propargite which are used for pest and disease ..
  24. Kumari B, Duhan A. Persistence of dicofol residues in cotton lint seed, and soil. Environ Monit Assess. 2011;182:129-32 pubmed publisher
    A supervised field trial was conducted at the CCS Haryana Agricultural University, Hisar to assess the residues of dicofol on cotton, during Kharif season, 2008. Dicofol (Kelthane 18.5EC) was applied at 500 g a.i./ha (T(1)) and 1,000 g a...
  25. MacLellan K, Bird D, Shutt L, Fry D. Behavior of captive american kestrels hatched from o,p'-dicofol exposed females. Arch Environ Contam Toxicol. 1997;32:411-5 pubmed
    ..American kestrels (Falco sparverius) to investigate the possible behavioral alterations from the compound o,p'-dicofol. Paired females were exposed to three levels of dicofol by oral gavage...
  26. Guo J, Wu F, Zhang L, Liao H, Tang Z, Zheng C, et al. Characteristics of DDTs in fish from Lake Taihu: an indicator of continual DDTs input in China. Sci Total Environ. 2012;437:196-9 pubmed publisher
    ..e., dicofol-type DDT, also occurred...
  27. Di Bella G, Saitta M, La Pera L, Alfa M, Dugo G. Pesticide and plasticizer residues in bergamot essential oils from Calabria (Italy). Chemosphere. 2004;56:777-82 pubmed
    ..Residues of dicofol and tetradifon were found in oils from both crop years. The mean dicofol concentration was 0...
  28. el Amrani S, Pena Abaurrea M, Sanz Landaluze J, Ramos L, Guinea J, Camara C. Bioconcentration of pesticides in zebrafish eleutheroembryos (Danio rerio). Sci Total Environ. 2012;425:184-90 pubmed publisher
    ..approaches for REACH application has been evaluated for three test compounds, chlorpyrifos, dicofol and atrazine...
  29. Stark J, Banken J. Importance of population structure at the time of toxicant exposure. Ecotoxicol Environ Saf. 1999;42:282-7 pubmed
    ..Populations of T. urticae were exposed to 100 ppm of the pesticide dicofol; populations of A. pisum were exposed to 200 ppm Neemix. The ri for the three control populations of T...
  30. Feng J, Hu P, Zhang F, Sun J. HCHs and DDTs in Yellow River of Henan section-a typical agricultural area in China: levels, distributions and risks. Environ Geochem Health. 2016;38:1241-1253 pubmed
    ..1 % p,p'-DDD in SPM. The ratios of (DDE + DDD)/∑DDTs and o,p'-DDT/p,p'-DDT revealed that the DDTs in the studied area mainly derived from long-term weathering of technical DDTs residue and the input of dicofol.
  31. Sugiyama S, Shimada N, Miyoshi H, Yamauchi K. Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis. Toxicol Sci. 2005;88:367-74 pubmed
    ..phthalate, and di-n-butyl phthalate), two herbicides (ioxynil and pentachlorophenol) and a miticide (dicofol) had 3,3',5-L-triiodothyronine- T(3)- antagonist activity at concentrations ranging from 10(-6) to 10(-5) M...
  32. Fernandez M, Pico Y, Manes J. Pesticide residues in oranges from Valencia (Spain). Food Addit Contam. 2001;18:615-24 pubmed
    ..3%) samples at a mean level of 1.05 mg/kg. Among the residues from pre-harvest treatment, dicofol was detected in 28 (18.7%) samples at a mean level of .28 mg/kg chlorpyriphos in 19 (12...
  33. Settimi L, Masina A, Andrion A, Axelson O. Prostate cancer and exposure to pesticides in agricultural settings. Int J Cancer. 2003;104:458-61 pubmed
    ..5, 95% CI = 1.4-4.2), more specifically to the often contemporary used compounds DDT (OR = 2.1, 95% CI = 1.2-3.8), and dicofol (OR = 2.8, 95% CI = 1.5-5.0), whose effects could not be well separated.
  34. Yin G, Athanassiadis I, Bergman A, Zhou Y, Qiu Y, Asplund L. A refined method for analysis of 4,4'-dicofol and 4,4'-dichlorobenzophenone. Environ Sci Pollut Res Int. 2017;24:13307-13314 pubmed publisher
    The acaricide, dicofol, is a well-known pesticide and partly a substitute for dichlorodiphenyltrichloroethane (DDT). Only few reports on environmental occurrence and concentrations have been reported calling for improvements...
  35. Rotenberg S, Weinstein I. Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium. Mol Carcinog. 1991;4:477-81 pubmed
    ..Of those compounds tested, kepone and dicofol significantly stimulated PKC activity in the absence, but not the presence, of Ca2+...
  36. Di Muccio A, Camoni I, Citti P, Pontecorvo D. Survey of DDT-like compounds in Dicofol formulations. Ecotoxicol Environ Saf. 1988;16:129-32 pubmed
    The levels of o,p'-DDE, p,p'-DDE, o,p'-DDT, p,p'-TDE (DDD), and p,p'-DDT were determined in 19 samples of Dicofol formulations commercially available in Italy...
  37. MacLellan K, Bird D, Fry D, Cowles J. Reproductive and morphological effects of o,p'-dicofol on two generations of captive American kestrels. Arch Environ Contam Toxicol. 1996;30:364-72 pubmed
    ..kestrels (Falco sparverius) to investigate the possible reproductive and teratogenic effects of the pesticide dicofol. Paired females were exposed to three levels of dicofol: 0, 5, and 20 mg/kg...
  38. Jadaramkunti U, Kaliwal B. Dicofol formulation induced toxicity on testes and accessory reproductive organs in albino rats. Bull Environ Contam Toxicol. 2002;69:741-8 pubmed
  39. Jadarmkunti U, Kaliwal B. Effect of dicofol formulation on estrous cycle and follicular dynamics in albino rats. J Basic Clin Physiol Pharmacol. 1999;10:305-14 pubmed
    It is very important to study the effects of pesticides on reproduction. Dicofol, an organochlorine pesticide, was administered orally at doses of 20, 30, 40 and 50 mg/kg body weight to normal virgin rats for 30 days...
  40. Stumpf N, Nauen R. Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae). J Econ Entomol. 2001;94:1577-83 pubmed
    ..Furthermore, strain AKITA showed cross-resistance to dicofol. The METI resistant strains AKITA and UK-99 showed 2.4- and 1...
  41. Oliveira J, Silva D, Martins E, Langenbach T, Dezotti M. Biodegradation of 14C-dicofol in wastewater aerobic treatment and sludge anaerobic biodigestion. Environ Technol. 2012;33:695-701 pubmed
    ..This work investigated the biodegradation of 14C-dicofol organochloride during wastewater aerobic treatment and sludge anaerobic biodigestion...
  42. Brunninger B, Mano D, Scheunert I, Langenbach T. Mobility of the organochlorine compound dicofol in soil promoted by Pseudomonas fluorescens. Ecotoxicol Environ Saf. 1999;44:154-9 pubmed
    ..Br 12, resistant to kanamycin and rifampycin, was used to follow the cotransport of the organochlorine acaricide dicofol through a nonsterilized soil column. P...
  43. Liu Y, Cao R, Qin P, Liu R. Assessing the potential toxic effect of one persistent organic pollutant: non-covalent interaction of dicofol with the enzyme trypsin. Spectrochim Acta A Mol Biomol Spectrosc. 2012;89:210-5 pubmed publisher
    ..We selectively study the interaction between dicofol (DCF) and trypsin by steady state and time resolved fluorescence quenching measurements and UV-visible absorption ..
  44. Zhou R, Zhu L, Chen Y, Kong Q. Concentrations and characteristics of organochlorine pesticides in aquatic biota from Qiantang River in China. Environ Pollut. 2008;151:190-9 pubmed
    ..Composition analyses in various environmental media indicated a recent usage of lindane and dicofol into the river.
  45. Wiemeyer S, Clark D, Spann J, Belisle A, Bunck C. Dicofol residues in eggs and carcasses of captive American kestrels. Environ Toxicol Chem. 2001;20:2848-51 pubmed
    ..Residues of dicofol and its metabolites were then analyzed in the eggs and carcasses of females...
  46. Hongsibsong S, Prapamontol T, Suphavilai C, Wipasa J, Pattarawarapan M, Kasinrerk W. Production of monoclonal antibody to acaricide dicofol and its derivatives. Hybridoma (Larchmt). 2010;29:495-500 pubmed publisher
    In Thailand detection of acaricide dicofol residues has been sporadically performed due to the limitation of analytical techniques...
  47. Liu Y, Liu R. The interaction of ?-chymotrypsin with one persistent organic pollutant (dicofol): spectroscope and molecular modeling identification. Food Chem Toxicol. 2012;50:3298-305 pubmed publisher
    Great attention is devoted to persistent organic pollutant (POP), among which the pesticide dicofol is critical related to food safety and might raise the risk of cancer incidence...
  48. Salghi R, Luis G, Rubio C, Hormatallah A, Bazzi L, Gutierrez A, et al. Pesticide residues in tomatoes from greenhouses in Souss Massa Valley, Morocco. Bull Environ Contam Toxicol. 2012;88:358-61 pubmed publisher
    ..The detected residue levels ranged from 0.001 to 0.400 mg kg(-1) for dicofol, from 0.003 to 0.170 mg kg(-1) for procymidone, from 0.001 to 0.250 mg kg(-1) for chlorothalonil, from 0.050 to 0...
  49. Amichot M, Tares S, Brun Barale A, Arthaud L, Bride J, Bergé J. Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism. Eur J Biochem. 2004;271:1250-7 pubmed
    ..The CYP6A2vSVL enzyme had an enhanced metabolism of DDT, producing dicofol, dichlorodiphenyldichloroethane and dichlorodiphenyl acetic acid...
  50. Luo F, Song J, Chen M, Wei J, Pan Y, Yu H. Risk assessment of manufacturing equipment surfaces contaminated with DDTs and dicofol. Sci Total Environ. 2014;468-469:176-85 pubmed publisher
    ..In the present study wipe-samples were taken from the surfaces of dicofol manufacturing equipment at a chemical factory in north China and analyzed for chemicals of concern (COCs)...
  51. Li S, Tian Y, Ding Q, Liu W. The release of persistent organic pollutants from a closed system dicofol production process. Chemosphere. 2014;94:164-8 pubmed publisher
    ..Samples of workshop air, waste water, waste acid, and the dicofol product were collected from a pesticide factory in China that uses a closed-system dicofol production process, ..
  52. Jiménez J, Bernal J, del Nozal M, Toribio L, Bernal J. Use of SPE-GC/EIMS for residue analysis in wine elaborated from musts spiked with formulations of chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol. J Sep Sci. 2007;30:547-56 pubmed
    ..Formulations containing chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol were added to must, which was subjected to a usual vinification...
  53. Krynitsky A, Stafford C, Wiemeyer S. Combined extraction-cleanup column chromatographic procedure for determination of dicofol in avian eggs. J Assoc Off Anal Chem. 1988;71:539-42 pubmed
    b>Dicofol in avian eggs was completely oxidized to dichlorobenzophenone (DCBP) when a hexane Soxhlet extraction procedure was used. This degradation did not occur with other avian tissues (muscle and liver)...