benzylidene compounds

Summary

Summary: Compounds containing the PhCH= radical.

Top Publications

  1. Shoji M, Sun A, Kisiel W, Lu Y, Shim H, McCarey B, et al. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. J Drug Target. 2008;16:185-97 pubmed
    ..It may also prove to be useful for treating drug-resistant tumors and micro-metastases in addition to primary tumors. ..
  2. Luberto C, Hassler D, Signorelli P, Okamoto Y, Sawai H, Boros E, et al. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002;277:41128-39 pubmed
    ..In conclusion, our results indicate that N-SMase activation is a necessary step for the full development of the cytotoxic program induced by TNF. ..
  3. Papke R, Porter Papke J. Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. Br J Pharmacol. 2002;137:49-61 pubmed
    ..Since these concentrations are relatively non-desensitizing, the contribution of choline-activated alpha7 receptor current may play a significant role in the regulation of calcium homeostasis in alpha7-expressing neurons. ..
  4. Thomas S, Zhong D, Zhou W, Malik S, Liotta D, Snyder J, et al. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle. 2008;7:2409-17 pubmed
  5. Marchesini N, Luberto C, Hannun Y. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003;278:13775-83 pubmed
    ..In conclusion, these results 1) show that nSMase2 is a structural gene for nSMase, 2) suggest that nSMase2 acts as a bona fide N-SMase in cells, and 3) implicate nSMase2 in the regulation of cell growth and cell signaling. ..
  6. Zhang J, Zhu D, Sheng R, Wu H, Hu Y, Wang F, et al. BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide. Eur J Pharmacol. 2009;613:1-9 pubmed publisher
    ..It is hopeful that BZYX becomes a potential candidate for use in the intervention for neurodegenerative diseases. ..
  7. Liang Y, Yin D, Hou L, Zheng T, Wang J, Meng X, et al. Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma. PLoS ONE. 2011;6:e23908 pubmed publisher
    ..Our study has offered a strategy that EF24 being a therapeutic agent for hepatocellular carcinoma. ..
  8. Thomas S, Zhao J, Li Z, Lou B, Du Y, Purcell J, et al. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem Pharmacol. 2010;80:1309-16 pubmed publisher
    ..These studies offer a novel strategy that combines the curcumin analog EF24 with a p38 inhibitor for potentially enhanced therapy in the treatment of lung cancer. ..
  9. Chatterjee P, Al Abed Y, Sherry B, Metz C. Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. Am J Physiol Cell Physiol. 2009;297:C1294-306 pubmed publisher
    ..Our results have significant implications for better understanding the therapeutic potential of cholinergic agonists for treating IL-6 mediated inflammatory conditions. ..

More Information

Publications62

  1. Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg N, Kutala V, et al. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem. 2007;282:28609-18 pubmed
    ..Therefore, EF24 appears to have a potential therapeutic role in human ovarian cancer through the activation of PTEN. ..
  2. Subramaniam D, May R, Sureban S, Lee K, George R, Kuppusamy P, et al. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer Res. 2008;68:1962-9 pubmed publisher
    ..Taken together, these data suggest that the novel curcumin-related compound EF24 is a potent antitumor agent that induces caspase-mediated apoptosis during mitosis and has significant therapeutic potential for gastrointestinal cancers. ..
  3. Pavlov V, Ochani M, Yang L, Gallowitsch Puerta M, Ochani K, Lin X, et al. Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit Care Med. 2007;35:1139-44 pubmed
    ..0006). These findings are of interest for the development of alpha7-nicotinic acetylcholine receptor agonists as a new class of anti-inflammatory therapeutics. ..
  4. Kasinski A, Du Y, Thomas S, Zhao J, Sun S, Khuri F, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008;74:654-61 pubmed publisher
    ..The effective inhibition of TNF-alpha-induced NF-kappaB signaling by EF24 extends the therapeutic application of EF24 to other NF-kappaB-dependent diseases, including inflammatory diseases such as rheumatoid arthritis. ..
  5. Pan Y, Wang Y, Cai L, Cai Y, Hu J, Yu C, et al. Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats. Br J Pharmacol. 2012;166:1169-82 pubmed publisher
    ..This novel compound is a potential anti-inflammatory agent and might be beneficial for the prevention of diabetic nephropathy. ..
  6. Capková K, Hixon M, Pellett S, Barbieri J, Johnson E, Janda K. Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. Bioorg Med Chem Lett. 2010;20:206-8 pubmed publisher
    ..A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported. ..
  7. Wheeler D, Knapp E, Bandaru V, Wang Y, Knorr D, Poirier C, et al. Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem. 2009;109:1237-49 pubmed publisher
  8. Aravind A, Sankar M, Varghese B, Baskaran S. Regioselective reductive cleavage of bis-benzylidene acetal: stereoselective synthesis of anticancer agent OGT2378 and glycosidase inhibitor 1,4-dideoxy-1,4-imino-l-xylitol. J Org Chem. 2009;74:2858-61 pubmed publisher
    ..By changing the order of deprotection, the chiral intermediate 6 was readily transformed to glycosidase inhibitor derivative 22. ..
  9. Czerwinska I, Juskowiak B. Photoisomerizable arylstilbazolium ligands recognize parallel and antiparallel structures of G-quadruplexes. Int J Biol Macromol. 2012;51:576-82 pubmed publisher
    ..The presence of quadruplex DNA hampered photoisomerization of quadruplex-bound ligand. ..
  10. Zhou S, You B, Yao Q, Chen M, Wang Y, Li W. DFT studies of structure and vibrational spectra of 4-benzylidene-1-phenyl-2-selenomorpholino-1H-imidazol-5(4H)-one and its derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2013;110:333-42 pubmed publisher
    ..Dimer model presents a better accuracy, but van del Waals correction on B3LYP hybrid function does not produce a significant change on accuracy in this system. ..
  11. El Mansy M, El Nahass M, Khusayfan N, El Menyawy E. DFT approach for FT-IR spectra and HOMO-LUMO energy gap for N-(p-dimethylaminobenzylidene)-p-nitroaniline (DBN). Spectrochim Acta A Mol Biomol Spectrosc. 2013;111:217-22 pubmed publisher
    ..Our calculated results have showed that the investigated compound possesses a dipole moment of 12 Debye and HOMO-LUMO energy gap of 2.94 eV which indicate high recommendations for photovoltaic devices fabrication. ..
  12. Li H, Hassona M, Lack N, Axerio Cilies P, Leblanc E, Tavassoli P, et al. Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer. Mol Cancer Ther. 2013;12:2425-35 pubmed publisher
    ..These results provide a foundation for the development of a new class of androgen receptor antagonists that can help address the problem of antiandrogen resistance in prostate cancer. ..
  13. Olivier B, Leahy C, Mullen T, Paylor R, Groppi V, Sarnyai Z, et al. The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?. Psychopharmacology (Berl). 2001;156:284-90 pubmed
    ..Alpha7 Nicotinergic receptor agonists were ineffective in this PPI paradigm. ..
  14. Gu W, Lu S, Ni Y, Liu Z, Zhou X, Zhu Y, et al. 2-(3',5'-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke. Neuroscience. 2016;316:26-40 pubmed publisher
    ..Taken together, our results indicate that DMBC can offer neuroprotective effects against cerebral ischemia with an extended therapeutic window and its mechanism might be associated with inhibition of the cathepsin B activation. ..
  15. Crich D, Pedersen C, Bowers A, Wink D. On the use of 3,5-O-benzylidene and 3,5-O-(di-tert-butylsilylene)-2-O-benzylarabinothiofuranosides and their sulfoxides as glycosyl donors for the synthesis of beta-arabinofuranosides: importance of the activation method. J Org Chem. 2007;72:1553-65 pubmed
  16. Crich D, Li L. 4,6-O-benzylidene-directed beta-mannopyranosylation and alpha-glucopyranosylation: the 2-deoxy-2-fluoro and 3-deoxy-3-fluoro series of donors and the importance of the O2-C2-C3-O3 interaction. J Org Chem. 2007;72:1681-90 pubmed
  17. Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, et al. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014;59:1118-29 pubmed publisher
    ..Exosomal transfer of miR-214 is a paradigm for the regulation of CCN2-dependent fibrogenesis and identifies fibrotic pathways as targets of intercellular regulation by exosomal miRs. ..
  18. Congiu C, Onnis V. Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents. Bioorg Med Chem. 2013;21:6592-9 pubmed publisher
    ..The determination of acute toxicity in athymic nudes mice proved some compounds to be non-toxic, making them good candidates for further study as antitumor agents. ..
  19. Surgucheva I, Sharov V, Surguchov A. ?-Synuclein: seeding of ?-synuclein aggregation and transmission between cells. Biochemistry. 2012;51:4743-54 pubmed publisher
    ..Our data suggest that post-translationally modified ?-synuclein possesses prion-like properties and may induce a cascade of events leading to synucleinopathies. ..
  20. Tronina T, Bartmańska A, Popłoński J, Huszcza E. Transformation of xanthohumol by Aspergillus ochraceus. J Basic Microbiol. 2014;54:66-71 pubmed publisher
    ..The major biotransformation product, was 8.6-fold stronger antioxidant than xanthohumol and 2.3-fold than ascorbic acid. ..
  21. Tang X, Shi M. An efficient route to 2-substituted N-(1-amino-3-methylpyrrol)amides by ring-opening cyclization of benzylidene- and alkylidenecyclopropylcarbaldehydes with hydrazides. J Org Chem. 2009;74:5983-6 pubmed publisher
    ..The in situ generated water significantly accelerates the reaction rate. A possible mechanism involving the cascade ring-opening and thermal-induced rearrangement to produce the five-membered ring is proposed. ..
  22. Shie C, Tzeng Z, Kulkarni S, Uang B, Hsu C, Hung S. Cu(OTf)2 as an efficient and dual-purpose catalyst in the regioselective reductive ring opening of benzylidene acetals. Angew Chem Int Ed Engl. 2005;44:1665-8 pubmed
  23. Suresh J, Vishnupriya R, Sivakumar S, Kumar R, Athimoolam S. Intermolecular C-H···O and C-H···X interactions in substituted spiroacenaphthylene structures. Acta Crystallogr C. 2012;68:o257-61 pubmed publisher
    ..In all three structures, molecules are linked through centrosymmetric ring motifs, further tailored through a relay of C-H···X [Cl in (I), Br in (II) and O in (III)] interactions. ..
  24. Sygula A, Karlen S, Sygula R, Rabideau P. Formation of the corannulene core by nickel-mediated intramolecular coupling of benzyl and benzylidene bromides: a versatile synthesis of dimethyl 1,2-corannulene dicarboxylate. Org Lett. 2002;4:3135-7 pubmed
  25. Brvar M, Perdih A, Hodnik V, Renko M, Anderluh G, Jerala R, et al. In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B. Bioorg Med Chem. 2012;20:2572-80 pubmed publisher
    ..The binding of the two most active compounds to the enzyme target was further characterised using surface plasmon resonance (SPR) and differential scanning fluorimetry methods (DSF). ..
  26. Sherman A, Mironov Y, Yudina O, Nifantiev N. The presence of water improves reductive openings of benzylidene acetals with trimethylaminoborane and aluminium chloride. Carbohydr Res. 2003;338:697-703 pubmed
  27. Dakin L, Block M, Chen H, Code E, Dowling J, Feng X, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012;22:4599-604 pubmed publisher
    ..The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data. ..
  28. Shi C, Yu R, Shao S, Li Y. Partial activation of ?7 nicotinic acetylcholine receptors: insights from molecular dynamics simulations. J Mol Model. 2013;19:871-8 pubmed publisher
    ..This conformation difference for the C-loop sheds light on the partial agonism of nAChR. ..
  29. Gomes L, Low J, Rodrigues A, Wardell J, Lima C, De Souza M. Five N'-benzylidene-N-methylpyrazine-2-carbohydrazides. Acta Crystallogr C. 2013;69:549-55 pubmed publisher
    ..There are ?-? stacking interactions in all five compounds. Three of these structures are compared with their nonmethylated counterparts, which have dihedral angles between the pyrazine rings and the benzene rings in the range 0-6°. ..
  30. Li Y, Meyer E, Walker D, Millard W, He Y, King M. Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures. J Neurochem. 2002;81:853-8 pubmed
  31. Baek M, Roy R. Synthesis and protein binding properties of T-antigen containing GlycoPAMAM dendrimers. Bioorg Med Chem. 2002;10:11-7 pubmed
    ..The inhibitory potential of these glycoPAMAM conjugates toward antibody-coating antigen interactions was enhanced up to 3800 times over that of the monomeric T-antigen residue (10). ..
  32. Sakaguchi N, Hirano S, Matsuda A, Shuto S. Radical reactions with 2-bromobenzylidene group, a protecting/radical-translocating group for the 1,6-radical hydrogen transfer reaction. Org Lett. 2006;8:3291-4 pubmed
    ..Using this PRT group, 4-branched ribose derivatives were stereoselectively prepared. ..
  33. Kem W, Mahnir V, Prokai L, Papke R, Cao X, LeFrancois S, et al. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol. 2004;65:56-67 pubmed
    ..Benzylidene anabaseines pharmacologically similar to the hydroxy metabolites, but which enter the brain more readily, may provide greater stimulation of alpha7 receptors in the whole organism. ..
  34. Saitoh A, Yoshikawa Y, Onodera K, Kamei J. Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats. Psychopharmacology (Berl). 2005;182:327-34 pubmed
    ..These results suggest that endogenous delta2-opioid-receptor-mediated systems are involved in the regulation of anxiety-related behaviors and might play a physiologically important role in the regulation of adrenocortical activity. ..
  35. Leite Silva C, Garcia F, Rodrigues J, Nakamura C, Ueda Nakamura T, Meyer E, et al. Synthesis, antitumor, antitrypanosomal and antileishmanial activities of benzo[4,5]canthin-6-ones bearing the N'-(Substituted benzylidene)-carbohydrazide and N-Alkylcarboxamide groups at C-2. Chem Pharm Bull (Tokyo). 2012;60:1372-9 pubmed
    ..4 to 16.70?µm. ..
  36. Ring J, Parkin S, Crooks P. (4-Methoxy-3-nitrobenzylideneamino)guanidinium chloride. Acta Crystallogr C. 2007;63:o392-4 pubmed
    ..In the title compound, C(9)H(12)N(5)O(3)(+) x Cl(-), the cation is almost entirely planar. The imine double bond is exclusively in the E geometry. ..
  37. Selvendiran K, Kuppusamy M, Bratasz A, Tong L, Rivera B, Rink C, et al. Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression. J Pharmacol Exp Ther. 2009;329:959-66 pubmed publisher
    ..HO-3867 is a potent drug, capable of overexpressing PTEN, which is a key target in the prevention of vascular remodeling, including restenosis. ..
  38. Papke R. Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). J Pharmacol Exp Ther. 2002;301:765-73 pubmed
    ..The ability of TC-2403 to protect receptor function from agonist-induced inhibition may point toward valuable new combination drug therapies. ..
  39. Hirose N, Murakawa K, Takada K, Oi Y, Suzuki T, Nagase H, et al. Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens. Neuroscience. 2005;135:213-25 pubmed
  40. Arias H, Xing H, MacDougall K, Blanton M, Soti F, Kem W. Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. Br J Pharmacol. 2009;157:320-30 pubmed publisher
    ..The desensitizing property of BAs suggests another possible mode of non-competitive inhibition in addition to direct channel-blocking mechanisms. ..
  41. Tashiro F, Sugiyama A, Urano Y, Kochi M. Sodium 5, 6-benzylidene-L-ascorbate induces in vitro neuronal cell differentiation accompanying apoptosis and necrosis. Anticancer Res. 2002;22:1423-31 pubmed
  42. El Nahass M, Kamel M, El Deeb A, Atta A, Huthaily S. Density functional theory (DFT) investigation of molecular structure and frontier molecular orbitals (FMOs) of P-N,N-dimethylaminobenzylidenemalononitrile (DBM). Spectrochim Acta A Mol Biomol Spectrosc. 2011;79:1499-504 pubmed publisher
    ..Also, its HOMO-LUMO gap decreased from 3.46 to 3.34 eV. From the cyclic voltammetry measurements the value of HOMO-LUMO gap is equal to 3.21 eV. This means that B3LYP/6-311++G(d,p) level of theory is the best one for calculations. ..
  43. Bertsch U, Winklhofer K, Hirschberger T, Bieschke J, Weber P, Hartl F, et al. Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. J Virol. 2005;79:7785-91 pubmed
    ..Moreover, SIFT-based screening may facilitate the search for drugs against other diseases linked to protein aggregation. ..
  44. Kim S, Ahn K, Jeon H, Lee D, Jung S, Jung K, et al. Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation. J Neurochem. 2010;112:1088-97 pubmed publisher
    ..This generation was suppressed by GW4869, an nSMase2 inhibitor, but not to fumonisin B(1), an inhibitor of the de novo ceramide synthesis pathway. The present study demonstrates the Ca2+-dependent activation of nSMase2. ..
  45. Han S, Inoue H, Terada T, Kamoda S, Saburi Y, Sekimata K, et al. N-benzylideneaniline and N-benzylaniline are potent inhibitors of lignostilbene-alpha,beta-dioxygenase, a key enzyme in oxidative cleavage of the central double bond of lignostilbene. J Enzyme Inhib Med Chem. 2003;18:279-83 pubmed
    ..The information obtained from the structure-activity relationships study here can aid in discovering inhibitors of both abscisic acid and vitamin A biosynthesis. ..
  46. Ovari L, Luo Y, Leyssner F, Haag R, Wolf M, Tegeder P. Adsorption and switching properties of a N-benzylideneaniline based molecular switch on a Au(111) surface. J Chem Phys. 2010;133:044707 pubmed publisher
    ..We propose that the photoisomerization is driven by a direct (intramolecular) electronic excitation of the adsorbed CBA molecules in the second ML (and above) analogous to CBA in the liquid phase. ..
  47. Bansal R, Acharya P. Synthesis and antileukemic activity of 16E-[4-(2-carboxy)ethoxybenzylidene]-androstene amides. Steroids. 2012;77:552-7 pubmed publisher
    ..94, 2.61, 6.90 and 1.79?M against CCRF-CEM, K-562, RPMI-8226 and SR leukemia cell lines, respectively. ..
  48. Olincy A, Stevens K. Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men. Biochem Pharmacol. 2007;74:1192-201 pubmed
    ..These data suggest that therapeutic agents selected for alpha7 nicotinic activity may have utility in treating certain symptoms of schizophrenia. ..
  49. Woodruff Pak D. Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning. Behav Brain Res. 2003;143:159-67 pubmed
    ..Reversal of mecamylamine-induced learning deficits by nicotine and GTS-21 suggests that nAChR agonists may have efficacy in ameliorating deficits caused by the loss of some types of nAChRs in diseases such as AD. ..
  50. Gao H, Guo W, Wang Q, Zhang L, Zhu M, Zhu T, et al. Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity. Bioorg Med Chem Lett. 2013;23:1776-8 pubmed publisher
  51. Radha A, Devi Rukhmini S, Sasikala V, Sakunthala P, Sreedharan B, Velayudhan M, et al. Bioactive derivatives of curcumin attenuate cataract formation in vitro. Chem Biol Drug Des. 2012;80:887-92 pubmed publisher
    ..These results indicated that curcumin and its derivatives--CD1 and CD2--are beneficial against selenite-induced cataract in vitro. Of these, CD1 is having higher bioactive potential compared with curcumin and CD2. ..
  52. Kittiwachana S, Wangkarn S, Grudpan K, Brereton R. Prediction of liquid chromatographic retention behavior based on quantum chemical parameters using supervised self organizing maps. Talanta. 2013;106:229-36 pubmed publisher
    ..The complex relationships between samples could be visualized using U-matrix and the influence of each variable on the predictive model could be investigated using component planes-which can provide chemical insight. ..
  53. Cheng H, Zhang L, Liu Y, Chen S, Cheng H, Lu X, et al. Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines. Eur J Med Chem. 2010;45:5950-7 pubmed publisher
    ..These composite results suggest that 4'-substituted 5-hydroxyaurone is indeed a candidate structural scaffold for anticancer agent targeting activated endothelial cells and fast-proliferating cancer cells. ..