phenylhydrazines

Summary

Summary: Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)

Top Publications

  1. Pruitt R, Hanson J, Safdi M, Wruble L, Hardi R, Johanson J, et al. Balsalazide is superior to mesalamine in the time to improvement of signs and symptoms of acute mild-to-moderate ulcerative colitis. Am J Gastroenterol. 2002;97:3078-86 pubmed
    ..Balsalazide is an effective and safe treatment for mild-to-moderate ulcerative colitis. Improvement of symptoms occurs considerably earlier with balsalazide than with mesalamine. ..
  2. Kimura I, Kawasaki M, Nagahama S, Matsuda A, Kataoka M, Kokuba Y. Determination of the active moiety of BX661A, a new therapeutic agent for ulcerative colitis, by studying its therapeutic effects on ulcerative colitis induced by dextran sulfate sodium in rats. Arzneimittelforschung. 1998;48:1091-6 pubmed
    ..Therefore, it seems that BX661A is clinically safe and more effective than SASP in the treatment of patients with ulcerative colitis. ..
  3. Levine D, Riff D, Pruitt R, Wruble L, Koval G, Sales D, et al. A randomized, double blind, dose-response comparison of balsalazide (6.75 g), balsalazide (2.25 g), and mesalamine (2.4 g) in the treatment of active, mild-to-moderate ulcerative colitis. Am J Gastroenterol. 2002;97:1398-407 pubmed
    ..4 g daily) in improving signs and symptoms of acute ulcerative colitis. Balsalazide (6.75 g daily) is well tolerated, and the safety profile does not differ from that of balsalazide (2.25 g daily) and mesalamine (2.4 g daily). ..
  4. Green J, Swan C, Gibson J, Kerr G, Swarbrick E, Thornton P. Patient-led variable dosing with balsalazide as long-term therapy for maintenance in ulcerative colitis: a 3-year prospective observational study. Aliment Pharmacol Ther. 2004;19:435-42 pubmed
    ..033). Long-term, patient-led, maintenance treatment with balsalazide is well tolerated with a good safety profile and is effective for patients with ulcerative colitis. ..
  5. Mackowiak J. A two-stage decision analysis to assess the cost of 5-aminosalicylic acid failure and the economics of balsalazide versus mesalamine in the treatment of ulcerative colitis. Manag Care Interface. 2006;19:39-46, 56 pubmed
    ..Coordinated efforts should be taken to avoid the cost and morbidity associated with 5-ASA treatment failures. ..
  6. MacGregor D, Kim Y, Sleisenger M, Johnson L. Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse. Int J Oncol. 2000;17:173-9 pubmed
    ..BSZ produces a dose-dependent chemopreventive effect on colon carcinogenesis. A possible mechanism is consistent with the inhibition of cellular proliferation and the induction of apoptosis. ..
  7. Menon M, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski D. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest. 2006;116:683-94 pubmed
    ..Stress erythropoiesis, therefore, requires stage-specific EpoR-PY343-Stat5 signals, some of which selectively bolster SCF and oncostatin-M action. ..
  8. Hirschler Laszkiewicz I, Zhang W, Keefer K, Conrad K, Tong Q, Chen S, et al. Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis. Exp Hematol. 2012;40:71-83 pubmed publisher
  9. Dodd D, Pluta L, Sochaski M, Wall H, Thomas R. Subchronic hepatotoxicity evaluation of hydrazobenzene in Fischer 344 rats. Int J Toxicol. 2012;31:564-71 pubmed publisher
    ..002 to 0.006 µg/mL in rats of the 200 or 300 ppm groups. A no observed effect level of 80 ppm (4.80 mg/kg per d) was selected based on the observation of microscopic hepatocyte alterations at ?200 ppm HZB. ..

More Information

Publications110 found, 100 shown here

  1. Turhan O, Tezbaşaran E. In situ observation of ninhydrin and phenylhydrazine reaction in solution by FTIR. Spectrochim Acta A Mol Biomol Spectrosc. 2013;113:297-301 pubmed publisher
    ..Both ratios resulted in same product (1,2,3-tris-phenylhydrazonoindan). The results showed that, phenylhydrazine react with all of the carbonyl groups in ninhydrin at both run. ..
  2. Ohno H, Tojo H, Kakihata K, Nomura M, Takayama S. Heinz body hemolytic anemia induced by DQ-2511, a new anti-ulcer drug, in dogs. Fundam Appl Toxicol. 1993;20:141-6 pubmed
    ..These results suggest that decreases in reduced glutathione in erythrocytes play an important role in the anemia and Heinz body formation induced by DQ-2511, but not by beta-acetylphenylhydrazine. ..
  3. Kles K, Vavricka S, Turner J, Musch M, Hanauer S, Chang E. Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum. Inflamm Bowel Dis. 2005;11:253-7 pubmed
    ..Physicians should use caution when providing higher doses of the pro-drug forms of 5-ASA to their patients, as this could lead to increased diarrhea. ..
  4. Marković S, Zižić J, Obradović A, Ognjanović B, Stajn A, Saičić Z, et al. Energy production and redox status of rat red blood cells after reticulocytosis induced by various treatments. Acta Biol Hung. 2011;62:122-32 pubmed publisher
  5. Sersen F, Gregan F, Kotora P, Kmetova J, Filo J, Loos D, et al. Synthesis and Free Radical Scavenging Activity of New Hydroxybenzylidene Hydrazines. Molecules. 2017;22: pubmed publisher
    ..and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N'-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by 1H-NMR, 13C-NMR, 19F-NMR, IR spectroscopy, LC-..
  6. Wefes I, Mastrandrea L, Haldeman M, Koury S, Tamburlin J, Pickart C, et al. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Proc Natl Acad Sci U S A. 1995;92:4982-6 pubmed
    ..These data implicate regulated components of the ubiquitin conjugation machinery in erythroid differentiation. ..
  7. Vokurka M, Krijt J, Sulc K, Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res. 2006;55:667-74 pubmed
    ..We propose that hepcidin is exclusively sensitive to iron utilization for erythropoiesis and hepatocyte iron balance, and these changes are not sensed by other genes involved in the control of iron metabolism in the liver. ..
  8. Hothi P, Lee M, Cullis P, Leys D, Scrutton N. Catalysis by the isolated tryptophan tryptophylquinone-containing subunit of aromatic amine dehydrogenase is distinct from native enzyme and synthetic model compounds and allows further probing of TTQ mechanism. Biochemistry. 2008;47:183-94 pubmed
    ..This is attributed to the absence of structural rearrangement prior to H-transfer that limits the rate of TTQ reduction by para-substituted benzylamines in native enzyme. ..
  9. Luo S, Wehr N. Protein carbonylation: avoiding pitfalls in the 2,4-dinitrophenylhydrazine assay. Redox Rep. 2009;14:159-66 pubmed publisher
    ..Avoiding oxidizing conditions, removal of nucleic acids, and prompt assay of samples can prevent artifactual effects on protein carbonyl measurements. ..
  10. Hou D, Fan J, Han L, Ruan X, Feng F, Liu W, et al. Determination of small halogenated carboxylic acid residues in drug substances by high performance liquid chromatography-diode array detection following derivatization with nitro-substituted phenylhydrazines. J Chromatogr A. 2016;1438:46-56 pubmed publisher
    ..Different nitro-substituted phenylhydrazines (NPHs) derivatization reagents were systematically compared and evaluated...
  11. Goto I, Agar N, Maede Y. Relation between reduced glutathione content and Heinz body formation in sheep erythrocytes. Am J Vet Res. 1993;54:622-6 pubmed
  12. Trifunovic A, Zaric J, Lusic M, Mijatovic M, Glisin V, Popovic Z. Induced synthesis of albumin-like protein in damaged rat reticulocytes. Br J Haematol. 2001;115:205-12 pubmed
    ..Haemolytic anaemia, either hereditary (b/b rat) or drug-induced (phenylhydrazine-treated normal rat), results in increased accumulation of the albumin-like protein in rat RBCs as a result of its induced synthesis. ..
  13. Biancone L, Tosti C, Fina D, Fantini M, de Nigris F, Geremia A, et al. Review article: maintenance treatment of Crohn's disease. Aliment Pharmacol Ther. 2003;17 Suppl 2:31-7 pubmed
    ..Several sub-clinical markers of relapse have indeed been reported in quiescent Crohn's disease, although their usefulness in clinical practice in currently uncertain. ..
  14. Radfar A, Diez A, Bautista J. Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum. Free Radic Biol Med. 2008;44:2034-42 pubmed publisher
    ..Targeting these processes might provide ways of combating chloroquine-resistance and developing new antimalarial drugs. ..
  15. Zamponi G, French R. Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence. Biophys J. 1994;67:1015-27 pubmed
    ..If so, our data place limits on the distance between this receptor and the intrapore site at which charged amines bind. ..
  16. Zaidi A, Michaelis M. Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase. Free Radic Biol Med. 1999;27:810-21 pubmed
    ..The PMCA appears to be very sensitive to inhibition by ROS and hence may be a target of oxidative stress in the aging brain. Reduction in its activity may contribute to age-related alterations in neuronal [Ca2+]i regulation. ..
  17. Hokari S, Miyazaki T, Matsunaga T, Koyama I, Hasegawa M, Komoda T. Expression of pyrimidine 5'-nucleotidase subclass I during erythrocyte maturation in rats. J Hematother Stem Cell Res. 2001;10:703-7 pubmed
    ..In conclusion, these findings indicate that the rat P5N-I enzyme is expressed specifically in reticulocytes and may therefore be essential in the maturation process of rat erythrocytes. ..
  18. Sultana R, Perluigi M, Butterfield D. Proteomics identification of oxidatively modified proteins in brain. Methods Mol Biol. 2009;564:291-301 pubmed publisher
    ..Separated proteins are identified following tryptic digestion, mass spectrometry, and interrogation of appropriate databases. ..
  19. Conrad C, Choi J, Malakowsky C, Talent J, Dai R, Marshall P, et al. Identification of protein carbonyls after two-dimensional electrophoresis. Proteomics. 2001;1:829-34 pubmed
    ..We have developed a method that allows the IPG strips to be derivatized with DNP directly following isoelectric focusing of the proteins. This method allows the visualization of oxidized proteins by 2-DE with high reproducibility. ..
  20. Frazer D, Inglis H, Wilkins S, Millard K, Steele T, McLaren G, et al. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut. 2004;53:1509-15 pubmed
  21. Zhu M, Chen Y, Loh T. Radical-mediated diamination of alkenes with phenylhydrazine and azodicarboxylates: highly diastereoselective synthesis of trans-diamines from cycloalkenes. Chemistry. 2013;19:5250-4 pubmed publisher
    ..This process works with the assistance of acetic acid by means of a radical mechanism and displays a high trans selectivity when cycloalkene substrates were used in the reaction. ..
  22. Korchazhkina O, Exley C, Andrew Spencer S. Measurement by reversed-phase high-performance liquid chromatography of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;794:353-62 pubmed
    ..181+/-0.063 microM/mmol creatinine. We demonstrate that the commonly used TBA assay in conjunction with HPLC may overestimate the MDA concentration in human urine by almost 10-fold. ..
  23. Diallo A, Gbeassor M, Vovor A, Eklu Gadegbeku K, Aklikokou K, Agbonon A, et al. Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats. Fitoterapia. 2008;79:332-6 pubmed publisher
    ..grandis enhanced the osmotic resistance of the red blood cells that confirm the important presence of young red blood cells. These results support partially the traditional use of T. grandis in the treatment of anaemia. ..
  24. Ryan A, Wang C, Laurieri N, Westwood I, Sim E. Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases. Protein Cell. 2010;1:780-90 pubmed publisher
    ..The low sequence identities observed among NAD(P)H quinone oxidoreductase and azoreductase enzymes suggests convergent evolution...
  25. Meyer B, Baum F, Vollmer G, Pischetsrieder M. Distribution of protein oxidation products in the proteome of thermally processed milk. J Agric Food Chem. 2012;60:7306-11 pubmed publisher
    ..The protein was identified by its peptide mass fingerprint as a variant of ?(S1)-casein (?(S1)-casein*). Similar oxidation patterns were observed in several commercial milk products. ..
  26. Zivny J, Gelderman M, Xu F, Piper J, Holada K, Simak J, et al. Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp-/-) mice. Blood Cells Mol Dis. 2008;40:302-7 pubmed
    ..These observations indicate that PrPc may modulate tissue hypoxia-sensing mechanisms or effect hypoxia target gene expression. ..
  27. Elias R, Laurie V, Ebeler S, Wong J, Waterhouse A. Analysis of selected carbonyl oxidation products in wine by liquid chromatography with diode array detection. Anal Chim Acta. 2008;626:104-10 pubmed publisher
    ..The technique offers good specificity, reproducibility (%RSD 0.45-10.6), and limits of detection (1.29-7.53microgL(-1)). The method was successfully used to monitor concentration changes of these compounds in both white and red wines. ..
  28. Li Y, Shao J, Yu X, Xu X, Lin H, Cai Z, et al. Design of two pyrazole-based sensors with similar configuration and different fluorescent response to anions. J Fluoresc. 2010;20:3-8 pubmed publisher
    ..The results of Job plots and ESI-mass spectrum indicate that L1 bind anions such as F(-), AcO(-), H(2)PO (4) (-) to form 2:1 host-guest complexation, while L2 bind anions to form 1:1 host-guest complexation in the solution. ..
  29. Yamada K, Hyodo S, Kinoshita M, Hayakawa T, Kakehi K. Hyphenated technique for releasing and MALDI MS analysis of O-glycans in mucin-type glycoprotein samples. Anal Chem. 2010;82:7436-43 pubmed publisher
    ..Kakehi, K. J. Proteome Res. 2009, 8, 521-537). We also applied the method to the analysis of O-glycans in serum samples. The present technique is the first attempt to use MS measurement for routine clinical diagnostic works. ..
  30. Linss W, Halbhuber K, Werner J, Zimmermann N, Meyer H. [Does induced Heinz body formation lead to the liberation of IgG receptors on the erythrocyte membrane?]. Acta Histochem Suppl. 1990;39:423-34 pubmed
    ..Photographs of such cells obtained by immunofluorescence microscopy are very similar to the pictures known from the literature. ..
  31. Korchazhkina O, Yang Y. Methyl malondialdehyde is not suitable as an internal standard for malondialdehyde detection in urine after derivatisation with 2,4-dinitrophenylhydrazine. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;806:295-8 pubmed
    ..We conclude, that MeMDA is not suitable as an internal standard for the measurement of MDA in urine under previously reported conditions when DNPH is used as a deriviatising agent. ..
  32. Dubois J, Klinman J. Role of a strictly conserved active site tyrosine in cofactor genesis in the copper amine oxidase from Hansenula polymorpha. Biochemistry. 2006;45:3178-88 pubmed
    ..The opposing effects of mutations at position 305 in biogenesis versus catalysis indicate that a single residue can be recruited for different roles during these processes. ..
  33. Igarashi J, Michel T. The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. Circ Res. 2008;102:630-2 pubmed publisher
  34. Wang T, Qing X, Dai C, Su Z, Wang C. Regioselective construction of 1,3-diaryl tetrahydroindazolones via the three-component reaction of 1,3-cyclohexanediones, β-nitrostyrenes and arylhydrazines. Org Biomol Chem. 2018;16:2456-2463 pubmed publisher
    ..a one-pot three-component system that combines substituted β-nitrostyrenes, 1,3-cyclohexanediones and phenylhydrazines. This reaction involves a highly efficient domino sequence consisting of the aza-Michael reaction, ..
  35. Novitskii V, Ryazantseva N, Shperling I, Filippova O, Rogov O. Mechanisms of hemolytic anemia during experimental methemoglobinemias. Bull Exp Biol Med. 2006;142:565-9 pubmed
    ..The severity and duration of anemia syndrome depended on chemical structure of xenobiotics, blood methemoglobin level, and the duration of the acute period of methemoglobinemia. ..
  36. Chen L, Jin H, Xu H, Sun L, Yu A, Zhang H, et al. Microwave-assisted extraction coupled online with derivatization, restricted access material cleanup, and high-performance liquid chromatography for determination of formaldehyde in aquatic products. J Agric Food Chem. 2009;57:3989-94 pubmed publisher
    ..The recoveries obtained by analyzing 11 spiked aquatic products were in the range of 70.0%-105.0%. The online technique was demonstrated to be rapid with little consumption of samples and reagents. ..
  37. Popova M, Chen C, Chen P, Huang C, Bankova V. A validated spectrophotometric method for quantification of prenylated flavanones in pacific propolis from Taiwan. Phytochem Anal. 2010;21:186-91 pubmed publisher
    ..Its application to a number of commercial samples could be used as a basis for standardisation and quality control of Pacific propolis. ..
  38. Zegota H. High-performance liquid chromatography of methanol released from pectins after its oxidation to formaldehyde and condensation with 2,4-dinitrophenylhydrazine. J Chromatogr A. 1999;863:227-33 pubmed
    ..The calibration curve was linear in the methanol concentration range between 0.04 and 15 micromol/ml (R=0.9995). The total recovery from pectin solutions spiked with methanol was equal to 100.6+/-5.1%. ..
  39. Fustero S, Román R, Sanz Cervera J, Simón Fuentes A, Cuñat A, Villanova S, et al. Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: synthesis and biological activity of fluorinated tebufenpyrad analogs. J Org Chem. 2008;73:3523-9 pubmed publisher
  40. Peh K, Wan B, Assem E, Pearce F. Effect of sulphasalazine and balsalazide on histamine release from mast cells. Inflamm Res. 2007;56 Suppl 1:S9-10 pubmed
  41. Barman B. Accurate determination of aldehydes in amine catalysts or amines by 2,4-dinitrophenylhydrazine derivatization. J Chromatogr A. 2014;1327:19-26 pubmed publisher
    ..These solutions have effective pHs of 10 or higher and provide much lower aldehyde concentrations compared to their true values. Mechanisms for the formation of 2,4-dinitrophenylhydrazones in both acidic and basic media are discussed. ..
  42. Bailey S, Patel V, Young T, Asayama K, Cunningham C. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res. 2001;25:726-33 pubmed
  43. Schulte Ladbeck R, Lindahl R, Levin J, Karst U. Characterization of chemical interferences in the determination of unsaturated aldehydes using aromatic hydrazine reagents and liquid chromatography. J Environ Monit. 2001;3:306-10 pubmed
    ..As with DNPH, the formation of a side product is observed. In contrast to DNPH, the alteration of the pH immediately after sampling leads to only one reaction product, which is stable and storable in solution at 4 degrees C for 2 days. ..
  44. Tucker S. Investigation of reagent distributions on glass fiber membrane filters used in air sampling. J Environ Monit. 2007;9:1122-30 pubmed
    ..Factors affecting the distribution of such coatings include choice of reagent and choice of solvent for the reagent solution. ..
  45. Schulzova V, Hajslova J, Peroutka R, Gry J, Andersson H. Influence of storage and household processing on the agaritine content of the cultivated Agaricus mushroom. Food Addit Contam. 2002;19:853-62 pubmed
    ..However, it is not yet known to what extent agaritine and other phenylhydrazine derivatives occurring in the cultivated mushroom are degraded into other biologically active compounds during the cooking procedure. ..
  46. Wang Y, Qiao L, Liu C, Lin N. [Effect and its mechanism of Coptis chinensis on oxidative hemolysis of erythrocytes in mice induced by acetylphenylhydrazine]. Zhongguo Zhong Yao Za Zhi. 2010;35:2449-52 pubmed
    ..To investigate the effect of Coptis chinensis on oxidative hemolysis of erythrocytes in mice...
  47. Zhang H, Zhan Y, Chang J, Liu J, Xu L, Wang Z, et al. Enzymatic synthesis of ?-N-(?-L(+)-glutamyl)phenylhydrazine with Escherichia coli ?-glutamyltranspeptidase. Biotechnol Lett. 2012;34:1931-5 pubmed publisher
    ..800 ml. After 6 h at 37 °C, the product was obtained with a conversion rate of 93 % (mol/mol). ?-Glutamyltranspeptidase was reversibly inhibited only when phenylhydrazine was above 300 mM. ..
  48. Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, et al. Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Biochim Biophys Acta. 2010;1800:669-73 pubmed publisher
    ..This is in contrast to the carcinogenic activity previously ascribed to this compound. Our results also show that this activity is distinct from that of beta-glucan, which indirectly suppresses proliferation of tumor cells. ..
  49. Nomura T, Yamamoto I, Morishita F, Furukawa Y, Matsushima O. Purification and some properties of alanine racemase from a bivalve mollusc Corbicula japonica. J Exp Zool. 2001;289:1-9 pubmed
    ..J. Exp. Zool. 289:1-9, 2001. ..
  50. Banerjee M, Ray A. The role of thyroid hormone on phenylhydrazine hydrochloride mediated inhibitory effects on blood acetylcholinesterase: an in vivo and in vitro study. J Biochem Mol Toxicol. 2002;16:162-8 pubmed
    ..Thus, thyroid hormone distinctly demonstrated a counteraction or protective nature of action on the PHH-induced inhibition of total blood and RBC membrane AChE activity. ..
  51. Uchiyama S, Matsushima E, Aoyagi S, Ando M. Simultaneous determination of C1-C4 carboxylic acids and aldehydes using 2,4-dinitrophenylhydrazine-impregnated silica gel and high-performance liquid chromatography. Anal Chem. 2004;76:5849-54 pubmed
    ..After sampling, the cartridges were heated at 80 degrees C for 5 h and extracted with acetonitrile for HPLC analysis. Under these optimized conditions, the LOD is 0.4 ug/m(3) for an air sample collected for 24 h at 100 mL/min (144 L). ..
  52. Ramot Y, Koshkaryev A, Goldfarb A, Yedgar S, Barshtein G. Phenylhydrazine as a partial model for beta-thalassaemia red blood cell hemodynamic properties. Br J Haematol. 2008;140:692-700 pubmed publisher
    ..It is proposed that PHZ-treated RBC resemble beta-thalassaemia RBC in their deformability and adhesiveness, but not in their aggregability, and thus can be used as a limited model for beta-thalassaemia RBC phenotypes. ..
  53. Uchiyama S, Inaba Y, Kunugita N. Determination of acrolein and other carbonyls in cigarette smoke using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine. J Chromatogr A. 2010;1217:4383-8 pubmed publisher
    ..This HQ-DNPH-method can be applied for the determination of acrolein and other alpha,beta-unsaturated aldehydes, such as crotonaldehyde, in cigarette smoke. ..
  54. Vemula S, Shi J, Mali R, Ma P, Liu Y, Hanneman P, et al. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Blood. 2012;120:2868-78 pubmed publisher
    ..These findings are expected to offer new perspectives on stress erythropoiesis and may provide a potential therapeutic target in human disease characterized by anemia. ..
  55. Porcheddu A, Mura M, De Luca L, Pizzetti M, Taddei M. From alcohols to indoles: a tandem Ru catalyzed hydrogen-transfer Fischer indole synthesis. Org Lett. 2012;14:6112-5 pubmed publisher
    ..Fischer indole synthesis, primary and secondary alcohols have been catalytically oxidized in the presence of phenylhydrazines and protic or Lewis acids to give the corresponding indoles...
  56. Jackowetz J, Mira de Orduña R. Improved sample preparation and rapid UHPLC analysis of SO2 binding carbonyls in wine by derivatisation to 2,4-dinitrophenylhydrazine. Food Chem. 2013;139:100-4 pubmed publisher
    ..Equipment utilisation could be reduced by rapid LC separation while maintaining analytical performance parameters. The improved method will be a valuable addition for the analysis of total SO2 binder pools in oenological samples. ..
  57. Amini N, Vousooghi N, Hadjighassem M, Bakhtiyari M, Mousavi N, Safakheil H, et al. Efficacy of Human Adipose Tissue-Derived Stem Cells on Neonatal Bilirubin Encephalopathy in Rats. Neurotox Res. 2016;29:514-24 pubmed publisher
    ..This study provides important information for the development of therapeutic strategies using human adiposity-derived stem cells in prenatal brain damage to reduce potential sensori motor deficit. ..
  58. Ninfali P, Palma F, Baronciani L, Piacentini G. Glucose-6-phosphate dehydrogenase activity and protein turnover in erythroblasts separated by velocity sedimentation at unit gravity and Percoll gradient centrifugation. Mol Cell Biochem. 1991;106:151-60 pubmed
    ..The rates of proteolysis obtained with total proteins and methyl-G6PDH clearly indicate that the proteolytic machinery of the erythroblasts reduces its activity during the cell maturation. ..
  59. Coleman D. Purification and properties of delta-aminolevulinate dehydratase from tissues of two strains of mice. J Biol Chem. 1966;241:5511-7 pubmed
  60. Hasegawa S, Rodgers G, Shio H, Schechter A, Uyesaka N. Impaired deformability of Heinz body-forming red cells. Biorheology. 1993;30:275-86 pubmed
    ..In summary, this study supports the conclusion that RBC deformability is impaired by the presence of Heinz bodies as well as the related oxidative damage involved in their formation. ..
  61. Maduka H, Okoye Z, Eje A. The influence of Sacoglottis gabonensis stem bark extract and its isolate bergenin, Nigerian alcoholic beverage additives, on the metabolic and haematological side effects of 2,4-dinitrophenyl hydrazine-induced tissue damage. Vascul Pharmacol. 2002;39:317-24 pubmed
    ..By virtue of its essentially similar activity under the same conditions, bergenin appears to be the phytochemical constituent that is largely responsible for the observed action of the bark extract. ..
  62. Nakanishi A, Kinuta K, Abe T, Araki K, Yoshida Y, Liang S, et al. Formation of meso, N-diphenylprotoporphyrin IX by an aerobic reaction of phenylhydrazine with oxyhemoglobins. Acta Med Okayama. 2003;57:249-56 pubmed
  63. Labieniec M, Gabryelak T. Measurement of DNA damage and protein oxidation after the incubation of B14 Chinese hamster cells with chosen polyphenols. Toxicol Lett. 2005;155:15-25 pubmed
    ..The used methods and obtained results provide additional information about the potential use of these phenols not only as antioxidants but also as pro-oxidants in biological systems. ..
  64. Shao J, Lin H, Lin H. A simple and efficient colorimetric anion receptor for H(2)PO(4)(-). Spectrochim Acta A Mol Biomol Spectrosc. 2008;70:682-5 pubmed
  65. Umukoro S, Ashorobi B. Further pharmacological studies on aqueous seed extract of Aframomum melegueta in rats. J Ethnopharmacol. 2008;115:489-93 pubmed
    ..The results of this study, suggest that Aframomum melegueta possess membrane-stabilizing activity, along with anti-oxidant property and may also have a modifying effect, on the responses of WBC to tissue injury. ..
  66. Siegel D, Rasenko T, Koch M, Nehls I. Determination of the Alternaria mycotoxin tenuazonic acid in cereals by high-performance liquid chromatography-electrospray ionization ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine. J Chromatogr A. 2009;1216:4582-8 pubmed publisher
    ..TA was detected in 13 and quantified in 3 out of 27 cereal samples obtained from a local supermarket, the average content being 49 microg/kg (highest incidence: 851+/-41 microg/kg). ..
  67. Draper H, Csallany A, Hadley M. Urinary aldehydes as indicators of lipid peroxidation in vivo. Free Radic Biol Med. 2000;29:1071-7 pubmed
    ..Consequently, urinalysis for aldehydic products of lipid peroxidation is an unreliable indicator of the general state of peroxidative stress in vivo. ..
  68. Johnson L, Pruitt R, Green J. Treatment of ulcerative colitis with balsalazide: response to editorial by Drs. Farrell and Peppercorn and letter to the editor by Dr. Hanauer. Am J Gastroenterol. 2003;98:216-9 pubmed
  69. Latunde Dada G, Vulpe C, Anderson G, Simpson R, McKie A. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004;1690:169-76 pubmed
    ..The probable association of the erythroid and the store regulators of iron homeostasis and absorption in the mice is discussed. ..
  70. Akiyama H, Kondo K. [Agaritine and phenylhydrazine derivatives in Agaricus bisporus and Agaricus blazei Murrill]. Shokuhin Eiseigaku Zasshi. 2007;48:J397-401 pubmed
  71. Chen X, Zhang T, Du G. Advanced glycation end products serve as ligands for lectin-like oxidized low-density lipoprotein receptor-1(LOX-1): biochemical and binding characterizations assay. Cell Biochem Funct. 2008;26:760-70 pubmed publisher
    ..LOX-1 serves as receptor for AGEs which may give some insight into the role of LOX-1 in the pathogenesis of diabetes and related disorders. ..
  72. Chandel A, Khan S, Kher R, Tiwari A. Investigation on the chemiluminescence reaction of the phenylhydrazine-luminol-peroxide system. Luminescence. 2012;27:455-8 pubmed publisher
    ..The effect of temperature on CL intensity has also been studied. The CL spectra revealed a broad peak at 425?nm, which suggests excited 3-aminophthalate ion as the luminophor. A mechanism to explain the reactions is suggested. ..
  73. Schreuder A, Rice A, Vaníkova J, Vitek L, Shapiro S, Verkade H. Albumin administration protects against bilirubin-induced auditory brainstem dysfunction in Gunn rat pups. Liver Int. 2013;33:1557-65 pubmed publisher
    ..Albumin treatment is neuroprotective in acute hyperbilirubinemia in Gunn rat pups. Our present results underline the importance of functional diagnostic test of neurotoxicity above biochemical concentrations. ..
  74. Wang K, Bermudez E, Pryor W. The ozonation of cholesterol: separation and identification of 2,4-dinitrophenylhydrazine derivatization products of 3 beta-hydroxy-5-oxo-5,6-secocholestan-6-al. Steroids. 1993;58:225-9 pubmed
    ..A possible mechanism involving an enamine functionality is proposed for the formation of 3a. The ratio of 3a/(3b + 3c) depends on the concentration of acid used and the reaction time. ..
  75. Frebort I, Pec P, Luhová L, Toyama H, Matsushita K, Hirota S, et al. Two amine oxidases from Aspergillus niger AKU 3302 contain topa quinone as the cofactor: unusual cofactor link to the glutamyl residue occurs only at one of the enzymes. Biochim Biophys Acta. 1996;1295:59-72 pubmed
    ..However, there may exist an unusual ester link between the topa-404 and Glu-145 in the native enzyme. ..
  76. Stopka T, Zakova D, Fuchs O, Kubrova O, Blafkova J, Jelinek J, et al. Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia. Leukemia. 2000;14:1247-52 pubmed
    ..In CD34+ AML progenitors over-expression of SMARCA5 may thus dysregulate the genetic program required for normal differentiation. ..
  77. Croci S, Pedrazzi G, Passeri G, Piccolo P, Ortalli I. Acetylphenylhydrazine induced haemoglobin oxidation in erythrocytes studied by Mössbauer spectroscopy. Biochim Biophys Acta. 2001;1568:99-104 pubmed
  78. Tanaka T, Wada K, Yamamori H, Tanaka S, Kudo T, Takeda M. [Biological markers for Alzheimer disease]. Seishin Shinkeigaku Zasshi. 2003;105:387-92 pubmed
    ..The result suggests that protein oxidation is highly involved in AD and that this method might be useful to differentiate AD from other neurological disease. ..
  79. Kaliman P, Strel chenko K, Barannik T, Nikitchenko I, Inshina N, Pavychenko O, et al. [Metabolism of heme and hemeproteins and some indices of the antioxidant system in rat erythrocytes and tissues under anemia caused by phenylhydrazine]. Fiziol Zh. 2003;49:66-72 pubmed
    ..The role of key enzymes of heme biosynthesis and degradation in adaptation of metabolism under phenylhydrazine action is discussed. ..
  80. Yu H, Chertkow H, Bergman H, Schipper H. Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma. Proteomics. 2003;3:2240-8 pubmed
    ..Moreover, the data implicate isoforms of Tf, Hpx and alpha-1-AT as potential biological markers of this condition. ..
  81. Herrington J, Fan Z, Lioy P, Zhang J. Low acetaldehyde collection efficiencies for 24-hour sampling with 2,4-dinitrophenylhydrazine (DNPH)-coated solid sorbents. Environ Sci Technol. 2007;41:580-5 pubmed
    ..These results indicate that assuming approximately 100% CEs for 24-hour acetaldehyde sampling, as commonly done with DNPH-coated solid sorbent methods, would substantially under estimate acetaldehyde concentrations. ..
  82. Guan X, Rubin E, Anni H. An optimized method for the measurement of acetaldehyde by high-performance liquid chromatography. Alcohol Clin Exp Res. 2012;36:398-405 pubmed publisher
    ..The method has an extended linear range, is reproducible and applicable to small-volume sampling of culture media and biological fluids. ..
  83. Zhang J, Al Eryani R, Ball H. Mass spectrometry analysis of 2-nitrophenylhydrazine carboxy derivatized peptides. J Am Soc Mass Spectrom. 2011;22:1958-67 pubmed publisher
    ..Finally, sequence scrambling is a charge dependent phenomenon, which affects CAD of doubly charged peptides far more than their singly charged counterparts. ..
  84. Anderson N, Javadi M, Berndl E, Berberovic Z, Bailey M, Huang K, et al. Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. PLoS ONE. 2013;8:e75472 pubmed publisher
    ..Our data suggest that perturbing JAK2 activation may have unexpected consequences in elevation of platelet number and correspondingly, important implications for treatment of hematological disorders with constitutive Jak2 activity. ..
  85. Peters L, White R, Birkenmeier C, Bloom M, Lux S, Barker J. Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo. Proc Natl Acad Sci U S A. 1992;89:5749-53 pubmed
  86. McKeveney P, Hodges V, Mullan R, Maxwell P, Simpson D, Thompson A, et al. Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. Br J Haematol. 2001;112:1016-24 pubmed
    ..Although ERIC-1/TACC3 is expressed in a wide range of tissues, its upregulation by Epo in erythroid progenitors implies that it has a role in terminal erythropoiesis. ..
  87. Tang C, Klinman J. The catalytic function of bovine lysyl oxidase in the absence of copper. J Biol Chem. 2001;276:30575-8 pubmed
    ..These studies demonstrate that the mature form of lysyl oxidase retains many of its functions in the absence of copper. ..
  88. Kruis W, Schreiber S, Theuer D, Brandes J, Schutz E, Howaldt S, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut. 2001;49:783-9 pubmed
    ..5 g twice daily) or a standard dose of mesalazine (0.5 g three times daily). All three treatments were safe and well tolerated. ..
  89. Szu S, Bystricky S. Physical, chemical, antigenic, and immunologic characterization of polygalacturonan, its derivatives, and Vi antigen from Salmonella typhi. Methods Enzymol. 2003;363:552-67 pubmed
  90. Maurer K, McShea A, Strathmann M, Dill K. The removal of the t-BOC group by electrochemically generated acid and use of an addressable electrode array for peptide synthesis. J Comb Chem. 2005;7:637-40 pubmed
  91. Rokushima M, Omi K, Imura K, Araki A, Furukawa N, Itoh F, et al. Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen. Toxicol Sci. 2007;100:290-302 pubmed
    ..These results indicate that altered splenic expression of a subset of genes may allow detection of drug-induced hemolytic anemia, with better sensitivity than that of erythrocyte counts in the blood. ..
  92. Scherl E, Pruitt R, Gordon G, Lamet M, Shaw A, Huang S, et al. Safety and efficacy of a new 3.3 g b.i.d. tablet formulation in patients with mild-to-moderately-active ulcerative colitis: a multicenter, randomized, double-blind, placebo-controlled study. Am J Gastroenterol. 2009;104:1452-9 pubmed publisher
    ..This new formulation with a reduced pill and dosing burden offers the potential to improve convenience and compliance in patients with active UC. ..