ethylene oxide

Summary

Alias: oxirane
Summary: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)

Webpages

  1. sterilization of materials for aseptic surgeries
    www.etsu.edu/animals/dlar/sterile.htm
  2. biosafety - physical containment and ppe
    www.hawaii.edu/ehso/bio/BSM_part06.htm
  3. molecular absorption spectra
    www.coe.ou.edu/sserg/web/Results/results.htm
  4. guidelines for sterilization & disinfection
    vetmed.duhs.duke.edu/guidelines_for_sterilization_disinfecti ...
  5. carcinogens
    safety.science.tamu.edu/carcinogens.html
  6. proceedings of the oklahoma academy of science
    digital.library.okstate.edu/OAS/oas_htm_files/v58/p102_105nf ...
  7. alcohols, ethers, phenols and derivatives
    www.chem.qmul.ac.uk/iupac/class/alcoh.html
  8. cases of industrial accidents occurred in japan
    ncsp.tamu.edu/reports/jicosh_jp/CasesofIAOJapan.htm
  9. xenopus oocyte collection template
    casemed.case.edu/ora/arc/templates_xenopus_oocyte_collection ...
  10. occupational safety and health administration - osha home page
    www.osha.gov

Research Grants

  1. A biodegradable ophthalmic drug delivery device
    L RAYMOND DEBARGE; Fiscal Year: 2008
  2. Terminal Sterilization of Tendon Allografts Using Supercritical CO2- Phase II
    Renee A Christopher; Fiscal Year: 2007
  3. Terminal Sterilization of Tendon Allografts Using Supercritical CO2- Phase II
    Renee A Christopher; Fiscal Year: 2008
  4. High-Performance Sterilant Gas for Dialysis Membranes
    JONATHAN S NIMITZ; Fiscal Year: 2005
  5. Etiology Of Allergic Reactions In Platelet And Granulocy
    Susan Leitman; Fiscal Year: 2002
  6. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
  7. Enhanced Management of Ethylene Oxide Sterilizers
    Sudipto Majumdar; Fiscal Year: 2005
  8. A New Method for Sterilizing Biomedical Materials
    PENNY T STARKEY; Fiscal Year: 2002
  9. Thromboresistant vascular grafts:heparin-peptidomimetics
    Paul O Zamora; Fiscal Year: 2004
  10. Tape Mechanical Occlusive Device (TMOD)
    Gerald W Timm; Fiscal Year: 2006

Publications

  1. Residual ethylene oxide in medical devices and device material
    Anne D Lucas
    Center for Devices and Radiological Health, Office of Science and Technology, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Biomed Mater Res B Appl Biomater 66:548-52
  2. Effect of re-sterilization of surgical sutures by ethylene oxide
    Prem Anand Nagaraja
    Narayana Hrudayalaya, Bommasandra Industrial Area, Anekal Taluk, Bangalore, Karnataka, India
    ANZ J Surg 77:80-3
  3. Safety of plasma-based sterilization: surface modifications of polymeric medical devices induced by Sterrad and Plazlyte processes
    S Lerouge
    Biomedical Engineering Institute, Ecole Polytechnique, Station Centre-ville, PO Box 6079, Montreal, Quebec H3C 3A7, Canada
    Biomed Mater Eng 12:3-13
  4. Effect of sterilization on the physicochemical properties of molded poly(L-lactic acid)
    Shawn J Peniston
    Poly Med, Inc, Anderson, South Carolina, USA
    J Biomed Mater Res B Appl Biomater 80:67-77
  5. Effectiveness of microwave sterilization on three hard chairside reline resins
    Karin Hermana Neppelenbroek
    Department of Dental Materials and Prosthodontics, São Paulo State University, Araraquara Dental School, São Paulo, Brazil
    Int J Prosthodont 16:616-20
  6. Absorbable sandwich-like membrane for retinal-sheet transplantation
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    J Biomed Mater Res 61:19-25
  7. Impact of sterilization on the porous design and cell behavior in collagen sponges prepared for tissue engineering
    Ernst Magnus Noah
    Department of Plastic, Hand, and Burn Surgery, Technology University of Aachen, Germany
    Biomaterials 23:2855-61
  8. In vivo change of elastic property in polyethylene acetabular components
    Atsushi Kusaba
    Institute of Joint Replacement and Rheumatology, Ebina General Hospital, Ebina, Kanagawa, Japan
    Mod Rheumatol 18:140-5
  9. Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, São Paulo, 13081-970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77
  10. Effectiveness of microwave irradiation on the disinfection of complete dentures
    Mariana Montenegro Silva
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, São Paulo State University, Brazil
    Int J Prosthodont 19:288-93

Scientific Experts

Detail Information

Webpages88 found, 30 most recent shown here

  1. sterilization of materials for aseptic surgeries
    www.etsu.edu/animals/dlar/sterile.htm
  2. biosafety - physical containment and ppe
    www.hawaii.edu/ehso/bio/BSM_part06.htm
  3. molecular absorption spectra
    www.coe.ou.edu/sserg/web/Results/results.htm
  4. guidelines for sterilization & disinfection
    vetmed.duhs.duke.edu/guidelines_for_sterilization_disinfecti ...
  5. carcinogens
    safety.science.tamu.edu/carcinogens.html
  6. proceedings of the oklahoma academy of science
    digital.library.okstate.edu/OAS/oas_htm_files/v58/p102_105nf ...
  7. alcohols, ethers, phenols and derivatives
    www.chem.qmul.ac.uk/iupac/class/alcoh.html
  8. cases of industrial accidents occurred in japan
    ncsp.tamu.edu/reports/jicosh_jp/CasesofIAOJapan.htm
  9. xenopus oocyte collection template
    casemed.case.edu/ora/arc/templates_xenopus_oocyte_collection ...
  10. occupational safety and health administration - osha home page
    www.osha.gov
  11. dow wolff cellulosics - products
    www.dow.com/dowwolff/en/products/index.htm#hyaluronic
  12. medical surveillance guidelines for ethylene oxide (non-mandatory) - 1910.1047 app c
    www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STAND ...
  13. americanchemistry.com : what is ethylene oxide
    www.americanchemistry.com/s_acc/sec_CPT.asp?CID=1467&DID=543 ...
  14. case no. 44 inhaling ethylene oxide gas during sterilization work in a hospital
    ncsp.tamu.edu/reports/jicosh_jp/44.htm
  15. peru
    pe.usps.gov/text/imm/ps_005.htm
  16. ivan rusyn
    genomics.unc.edu/rusyn/rusyn_dw.htm
  17. electrochemistry encyclopedia – change of address
    electrochem.cwru.edu/ed/encycl/art-b01-brine.htm
  18. organic chemistry faculty - michael e. jung
    www.chem.ucla.edu/dept/Organic/Jung_Brochure.html
  19. b:g6a$n8&5f6h@s%j%9%h(b($b?@ln@6>!(b
    tutms.tut.ac.jp/STAFF/JINNO/pub.html
  20. riboflavin (vitamin b2
    www.chm.bris.ac.uk/webprojects2002/schnepp/vitaminb2.html
  21. international council of nurses [fact sheet - icn on disinfectants and sterilants
    www.icn.ch/matters_disinfectants.htm
  22. dinesh o. shah - chemical engineering at the university of florida
    www.che.ufl.edu/faculty/shah/
  23. radoslav bogoslovov's research on polymer electrolytes - resume, cv
    www.physics.unlv.edu/~radoslav/resume.htm
  24. our physicians - health information
    www.memorialhealth.com/healthinfo/content.aspx?pageid=P00705
  25. publications
    www.chem.ox.ac.uk/bayleygroup/Publications.htm
  26. max-planck-institut für kolloid- und grenzflächenforschung, potsdam - 2005
    www.mpikg-golm.mpg.de/kolloidchemie/Leitung/Publikationen/20 ...
  27. genomics|hugenet|fact sheets|gstm1, gstt1, and the risk of squamous cell carcinoma of the head and neck redirect
    www.cdc.gov/genomics/hugenet/factsheets/FS_GSTMIGSTTI.htm
  28. poly(acrylonitrile
    web.mst.edu/~WLF/Synthesis/pacrylonitrile.html
  29. silent spring institute | breast cancer and the environment
    www.silentspring.org/breast-cancer-and-environment/fact-shee ...

Research Grants37

  1. A biodegradable ophthalmic drug delivery device
    L RAYMOND DEBARGE; Fiscal Year: 2008
    ..material under dry and wet conditions; 2) the in vitro rate of drug elution from samples; 3) the effect of ethylene oxide sterilization on the drug-nanofiber mat samples; and 4) the in vitro biocompatibility of samples with human ..
  2. Terminal Sterilization of Tendon Allografts Using Supercritical CO2- Phase II
    Renee A Christopher; Fiscal Year: 2007
    ..The only two processes capable of terminal sterilization of allografts are ethylene oxide and gamma irradiation which suffer from major drawbacks if used at a concentration to achieve SAL6 thus ..
  3. Terminal Sterilization of Tendon Allografts Using Supercritical CO2- Phase II
    Renee A Christopher; Fiscal Year: 2008
    ..The only two processes capable of terminal sterilization of allografts are ethylene oxide and gamma irradiation which suffer from major drawbacks if used at a concentration to achieve SAL6 thus ..
  4. High-Performance Sterilant Gas for Dialysis Membranes
    JONATHAN S NIMITZ; Fiscal Year: 2005
    ..The new sterilant gas should be marketable worldwide and should allow use of existing ethylene oxide (EO) sterilizing equipment, thus reducing costs of medical care...
  5. Etiology Of Allergic Reactions In Platelet And Granulocy
    Susan Leitman; Fiscal Year: 2002
    ..tests (RAST), and basophil histamine release assays, specific IgE-mediated sensitization to ethylene oxide, a gas used to sterilize the plastic disposable apheresis kits, was found in ten of 16 plateletpheresis donors ..
  6. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2007
    ..Task 3. Conduct experiments designed to extend the use of F-spores for sterilization processes using ethylene oxide, hydrogen peroxide gas plasma, and radiation...
  7. Enhanced Management of Ethylene Oxide Sterilizers
    Sudipto Majumdar; Fiscal Year: 2005
    DESCRIPTION (provided by applicant): The effectiveness of ethylene oxide (EtO) for destroying pathogens in the case of heat and moisture sensitive materials has led to its wide spread use in sterilization processes...
  8. A New Method for Sterilizing Biomedical Materials
    PENNY T STARKEY; Fiscal Year: 2002
    ..that would be compatible with emerging biomaterials and biomimetic structures and would eventually replace ethylene oxide as a sterilization method. In particular, sterilization of the new synthetic extracellular matrix, a.k.a...
  9. Thromboresistant vascular grafts:heparin-peptidomimetics
    Paul O Zamora; Fiscal Year: 2004
    ..will also be conducted to establish if the peptide/heparin-coated graft can withstand sterilization with ethylene oxide, the preferred sterilization route for ePTFE...
  10. Tape Mechanical Occlusive Device (TMOD)
    Gerald W Timm; Fiscal Year: 2006
    ..b>Ethylene Oxide sterilization processes will be validated during the course of the grant and used to sterilize TMOD devices in ..
  11. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William E Collins; Fiscal Year: 2003
    ..the biocompatibility of an exciting family of biomaterials, polydimethylsiloxanes end-functionalized with poly(ethylene oxide) (PEO siloxanes), to further such design...
  12. A New Artificial Corneal Prosthesis (kPro)
    THOMAS C WHITE; Fiscal Year: 2002
    ..5-0.7mm with strength of 50 Newtons; 3) an independent laboratory determination of bioburden and ethylene oxide sterilization validation, and toxicology testing...
  13. Novel Polymers for Tissue Engineering
    Robert S Langer; Fiscal Year: 2008
    ..to grow tissue engineered cartilages that resemble native neocartilages by injecting a mixture of poly(ethylene oxide) dimethacrylate and chondrocytes followed by transdermal photopolymerization...
  14. Novel Polymers for Tissue Engineering
    Robert S Langer; Fiscal Year: 2007
    ..to grow tissue engineered cartilages that resemble native neocartilages by injecting a mixture of poly(ethylene oxide) dimethacrylate and chondrocytes followed by transdermal photopolymerization...
  15. A BIOMIMETIC BARRIER FOR ISLET IMMUNOISOLATION
    Elliot L Chaikof; Fiscal Year: 2002
    ..2) Define the transport characteristics of dendrimer based molecular channels. Poly(ethylene oxide) (PEO) dendrimers with macromolecular generations will be synthesized, end-functionalized with a polymerizable ..
  16. Smart Lidocaine Gels for Pain Management
    CHIRAKKAL KRISHNAN; Fiscal Year: 2008
    ..smart gels, containing lidocaine (an anesthetic drug) and mixtures of pluronic-based block copolymers (poly (ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)) in water, can be fine-tuned by copolymer composition and ..
  17. Smart Lidocaine Gels for Pain Management
    CHIRAKKAL KRISHNAN; Fiscal Year: 2007
    ..smart gels, containing lidocaine (an anesthetic drug) and mixtures of pluronic-based block copolymers (poly (ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)) in water, can be fine-tuned by copolymer composition and ..
  18. Interactions of Pluronic block copolymers in drug resistant cancer
    Alexander V Kabanov; Fiscal Year: 2007
    ..This goal is achieved by combining anti-cancer drugs and block copolymers of poly(ethylene oxide) and polypropylene oxide) ("Pluronics")...
  19. Cross-linked Polymer Micelles in Cancer Therapy
    Tatiana K Bronich; Fiscal Year: 2008
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  20. In-Vivo Study of an Oxirane Low Shrink-Stress Composite
    JOHN HENRY PURK; Fiscal Year: 2008
    ..Public Health Relevance: This Public Health Relevance is not available...
  21. Cross-linked Polymer Micelles in Cancer Therapy
    Tatiana K Bronich; Fiscal Year: 2007
    ..The nanofabrication of these micelles involves condensation of diblock copolymers of poly(ethylene oxide) (PEO) and poly(carboxylic acid) by divalent metal cations into spherical micelles of core-shell morphology...
  22. In-Vivo Study of an Oxirane Low Shrink-Stress Composite
    JOHN HENRY PURK; Fiscal Year: 2007
    ....
  23. Core B: Biomarkers Core
    Stephen S Hecht; Fiscal Year: 2008
    ..and butadiene in urine; anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-hemoglobin adducts, ethylene oxide-hemoglobin adducts, and hemoglobin adducts of ethylating agents...
  24. LC-MS/MS FOR HIGHLY SENSITIVE BIOMARKER DETECTION
    James A Swenberg; Fiscal Year: 2005
    ..into cisplatin DNA adducts, lipid composition, molecular dosimetry of DNA adducts derived from butadiene, ethylene oxide, propylene oxide and isoprene, and studies on choline metabolism, cancer causality and susceptibility, DNA ..
  25. Interactions of Block Copolymers in Blood Brain Barrier
    Alexander V Kabanov; Fiscal Year: 2006
    ..the brain delivery of drugs across the blood brain barrier (BBB) using a novel drug delivery system, poly(ethylene oxide)-poly(propylene oxide) block copolymers (Pluronic) or "poloxamer")...
  26. Three-Membered Ring Metabolites, Inhibition & Formation
    Hung-wen Liu; Fiscal Year: 2006
    ..This enzyme holds potential to be used to prepare bioactive agents containing a reactive oxirane group...
  27. Tissue Engineering Application to Craniofacial Defects
    PATRICIA S ARAUZ; Fiscal Year: 2008
    ..The polymer used to fabricate the hydrogel scaffold is poly ethylene oxide diacrylate and other modified versions of this polymer, which provide improved properties...
  28. Nanostructured Dental Composite Restorative Materials
    J David Eick; Fiscal Year: 2007
    ..stress using nanoclay fillers producing improved mechanical properties combined with BisGMA/TEGDEMA and/or oxirane resins...
  29. Nanostructured Dental Composite Restorative Materials
    J David Eick; Fiscal Year: 2008
    ..stress using nanoclay fillers producing improved mechanical properties combined with BisGMA/TEGDEMA and/or oxirane resins...
  30. Three-membered Ring Metabolites, Inhibition and Formation
    Hung-wen Liu; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): Many natural products contain cyclopropane, oxirane, or aziridine groups as key structural elements. These three-membered ring moieties are generally stable despite their considerable ring strain...
  31. Tissue Engineering Application to Craniofacial Defects
    PATRICIA S ARAUZ; Fiscal Year: 2007
    ..The polymer used to fabricate the hydrogel scaffold is poly ethylene oxide diacrylate and other modified versions of this polymer, which provide improved properties...
  32. Biomarkers Of Effect-Assessment Of Ethylene Oxide Tumors
    Robert C Sills; Fiscal Year: 2002
    b>Ethylene oxide was classified as a known human carcinogen by the International Agency for Research on Cancer (IARC) and was based on its potential to induce a persistent dose-related increase in the frequency of chromosomal aberrations ..
  33. BATZELLADINE A FOR SELECTIVE ANTIHIV DRUG DELIVERY
    David Y Gin; Fiscal Year: 2002
    ..Preparation of the block-copolymer for micelle construction involves the synthesis of poly(ethylene oxide)-poly(b-benzyl-L-aspartate) block copolymer, whose size, stability and drug housing capacity present an ..
  34. LONG-CIRCULATING TUMOR-SELECTIVE DNA DELIVERY SYSTEMS
    Mansoor M Amiji; Fiscal Year: 2005
    ..in the systemic circulation, long-circulating poly (ethylene glycol)-grafted (PEGylated) gelatin and poly (ethylene oxide) (PEO)-modified poly (beta-amino ester) nanoparticles will be taken up by the tumor mass due to the enhanced ..
  35. Development of Nanoscale Neuromodulationg Platforms
    David R Pepperberg; Fiscal Year: 2003
    ..GABAc receptors) expressed in Xenopus oocytes. The platform's active surface will consist of alkyl and poly(ethylene oxide) chains that are covalently linked to the surface, derivatized with a ferrocene/ferricinium moiety, and ..

Publications62

  1. Residual ethylene oxide in medical devices and device material
    Anne D Lucas
    Center for Devices and Radiological Health, Office of Science and Technology, U S Food and Drug Administration, Rockville, MD 20852, USA
    J Biomed Mater Res B Appl Biomater 66:548-52
    b>Ethylene oxide (EO) gas is commonly used to sterilize medical devices. The amount of residual EO remaining in a device depends partly on the type and size of polymeric material...
  2. Effect of re-sterilization of surgical sutures by ethylene oxide
    Prem Anand Nagaraja
    Narayana Hrudayalaya, Bommasandra Industrial Area, Anekal Taluk, Bangalore, Karnataka, India
    ANZ J Surg 77:80-3
    ..These unused sutures with their foil packs still unopened are sometimes re-sterilized using ethylene oxide to allow for reuse...
  3. Safety of plasma-based sterilization: surface modifications of polymeric medical devices induced by Sterrad and Plazlyte processes
    S Lerouge
    Biomedical Engineering Institute, Ecole Polytechnique, Station Centre-ville, PO Box 6079, Montreal, Quebec H3C 3A7, Canada
    Biomed Mater Eng 12:3-13
    Plasma-based sterilization is a promising alternative to the use of pure ethylene oxide (EO), for low-temperature clinical sterilization of medical instruments and devices...
  4. Effect of sterilization on the physicochemical properties of molded poly(L-lactic acid)
    Shawn J Peniston
    Poly Med, Inc, Anderson, South Carolina, USA
    J Biomed Mater Res B Appl Biomater 80:67-77
    ..The hydrogen peroxide gas plasma (HPGP) sterilization process was comparatively investigated against ethylene oxide (EtO)...
  5. Effectiveness of microwave sterilization on three hard chairside reline resins
    Karin Hermana Neppelenbroek
    Department of Dental Materials and Prosthodontics, São Paulo State University, Araraquara Dental School, São Paulo, Brazil
    Int J Prosthodont 16:616-20
    ..Specimens of three reline resins (Kooliner, Tokuso Rebase, and Ufi Gel Hard) were fabricated and subjected to ethylene oxide sterilization...
  6. Absorbable sandwich-like membrane for retinal-sheet transplantation
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    J Biomed Mater Res 61:19-25
    ..Three sterilization methods were conducted, with hydrogen peroxide gas plasma (HPGP), ethylene oxide (EO), and gamma-ray irradiation (gamma). The results were compared with those of a control (no disinfection)...
  7. Impact of sterilization on the porous design and cell behavior in collagen sponges prepared for tissue engineering
    Ernst Magnus Noah
    Department of Plastic, Hand, and Burn Surgery, Technology University of Aachen, Germany
    Biomaterials 23:2855-61
    ..Collagen sponges with uniform pore size (20 microm) were sterilized either with ethylene oxide (EO) or gamma irradiation (2.5 Mrad)...
  8. In vivo change of elastic property in polyethylene acetabular components
    Atsushi Kusaba
    Institute of Joint Replacement and Rheumatology, Ebina General Hospital, Ebina, Kanagawa, Japan
    Mod Rheumatol 18:140-5
    ..Thirty-two cups were sterilized by gamma irradiation in air and 24 by ethylene oxide gas (EtO)...
  9. Effects of different sterilization methods on the morphology, mechanical properties, and cytotoxicity of chitosan membranes used as wound dressings
    Paula Rulf Marreco
    Department of Biotechnological Processes, School of Chemical Engineering, PO Box 6066, State University of Campinas, São Paulo, 13081-970, Brazil
    J Biomed Mater Res B Appl Biomater 71:268-77
    ..work was to compare the effects induced by two different sterilization methods (exposure to gamma radiation or ethylene oxide) and an antiseptic technique (immersion in 70% ethanol aqueous solution) on the morphology, tensile strength, ..
  10. Effectiveness of microwave irradiation on the disinfection of complete dentures
    Mariana Montenegro Silva
    Department of Dental Materials and Prosthodontics, Araraquara Dental School, São Paulo State University, Brazil
    Int J Prosthodont 19:288-93
    ..MATERIALS AND METHODS: Eighty dentures were fabricated in a standardized procedure and subjected to ethylene oxide sterilization...
  11. Effects of ethylene oxide and steam sterilization on dialysis-induced cytokine release by cuprophan membrane
    Filippo Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo FG, Italy
    Artif Organs 26:543-5
    ..They were using a 1.3 m2 ethylene oxide (E3) or steam (E3S) sterilized Cuprophan membrane...
  12. Is steam sterilization really making any difference in dialysis-induced cytokine release?
    F Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo Italy
    Int J Artif Organs 25:832-7
    b>Ethylene oxide (ETO) is presently the most commonly used sterilization method for medical devices...
  13. Effect of an accelerated aging protocol on viscoelastic properties of UHMWPE
    Gladius Lewis
    Department of Mechanical Engineering, The University of Memphis, TN 38152-3180, USA
    Biomed Mater Eng 12:299-308
    ..Two sets comprised specimens that had been sterilized (using gamma radiation in air or ethylene oxide gas) while the other two sets comprised specimens that were sterilized and then exposed to an accelerated ..
  14. Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds
    Kirstie D Andrews
    UK Centre for Tissue Engineering, Division of Clinical Engineering, Duncan Building, Daulby Street, University of Liverpool, Liverpool, L69 3GA, UK
    Biomaterials 28:1014-26
    ..Scaffolds made from Tecoflex SG-80A polyurethane were sterilised using ethylene oxide and UV-ozone...
  15. Effect of gamma, ethylene oxide, electron beam, and plasma sterilization on the behaviour of SR-PLLA fibres in vitro
    Juha-Pekka Nuutinen
    Institute of Biomaterials, Tampere University of Technology, PO Box 589, FIN-33101, Tampere, Finland
    J Biomater Sci Polym Ed 13:1325-36
    ..The samples were sterilized using plasma, ethylene oxide (one and two cycles), gamma (25 kGy at room temperature, 25 kGy in dry ice, and 2 x 25 kGy at room temperature)..
  16. Comparison of the effects of sterilisation techniques on subsequent DNA profiling
    Kirsty Shaw
    Department of Forensic Science and Drug Monitoring, King s College London, London, SE1 9NH, UK
    Int J Legal Med 122:29-33
    ..Four sterilisation techniques (UV, gamma and beta radiation and ethylene oxide treatment) were examined for their potential to degrade contaminating DNA to such an extent that subsequent ..
  17. Long-term in vivo wear performance of porous-coated acetabular components sterilized with gamma irradiation in air or ethylene oxide
    Karl F Orishimo
    Anderson Orthopaedic Research Institute, Alexandria, VA 22306, USA
    J Arthroplasty 18:546-52
    ..28 hips implanted with Arthropor cups (Joint Medical Products, Stamford, CT) that were sterilized with ethylene oxide. Time-dependent variations in the radiographic wear rates were compared within each group...
  18. Enhanced retention of polymer physical characteristics and mechanical strength of 70:30 poly(L-lactide-co-D,L-lactide) after ethylene oxide sterilization
    Anastasia J McManus
    MacroPore Biosurgery, a Cytori Therapeutics Company, 3020 Callan Road, San Diego, California 92121, USA
    J Biomed Mater Res B Appl Biomater 82:325-33
    This study examined the effect of ethylene oxide (EtO) and electron beam (e-beam) irradiation on the properties of 70:30 poly(L-lactide-co-D,L-lactide)...
  19. A decontamination and sterilization protocol employed during reuse of cardiac electrophysiology catheters inactivates human immunodeficiency virus
    Julian D Druce
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Australia
    Infect Control Hosp Epidemiol 24:184-90
    ..no treatment, (2) washing in general purpose detergent, (3) washing in enzyme cleaner, (4) sterilization in ethylene oxide, or (5) the full protocol of sequential detergent-enzyme cleaner-ethylene oxide exposure...
  20. Technical views
    Helene Olefsky
    Nephrol News Issues 17:12
  21. Sterlization techniques for the dental office
    Rodney M Stine
    Tex Dent J 121:240-2
  22. A histological and immunohistochemical study of tissue reactions to solid poly(ortho ester) in rabbits
    M Ekholm
    Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Int J Oral Maxillofac Surg 35:631-5
    ..Resorption times and the effect of 2 different sterilization methods (gamma radiation and ethylene oxide) upon resorption were also evaluated...
  23. Sterilisation of bioresorbable polymer implants
    M Bernkopf
    BBF Sterilisations service GmbH Kernen, Germany
    Med Device Technol 18:26, 28-9
    ..The suitability of different sterilisation methods for bioresorbable polymers is discussed using polylactic acid implants as an example...
  24. The effect of choice of sterilisation method on the biocompatibility and biodegradability of SIS (small intestinal submucosa)
    Marguerita Grimes
    Biomedical Engineering Research Centre, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Limerick, Ireland
    Biomed Mater Eng 15:65-71
    ..Currently SIS products are sterilised using ethylene oxide, gamma irradiation and e-beam irradiation...
  25. In vitro cytotoxicity testing of AB-polymer networks based on oligo(epsilon-caprolactone) segments after different sterilization techniques
    Dorothee Rickert
    Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Prittwitzstrasse 43, D 89075 Ulm, Germany
    J Biomed Mater Res B Appl Biomater 67:722-31
    ..The influence of the different sterilization techniques on the cytotoxicity of the polymeric material, as well as the clinical relevance of the described differences, are discussed...
  26. Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture
    Jason Hodde
    Cook Biotech Incorporated, 1425 Innovation Place, West Lafayette, IN 47906, USA
    J Mater Sci Mater Med 18:537-43
    The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of ..
  27. Detection of viable fungal spores contaminant on documents and rapid control of the effectiveness of an ethylene oxide disinfection using ATP assay
    Malalanirina S Rakotonirainy
    Centre de Recherches sur la Conservation des Documents Graphiques CRCDG, MNHN MCC CNRS UMR 8573, 36 rue Geoffroy Saint Hilaire, 75005 Paris, France
    Luminescence 18:113-21
    ..The validity of the procedure was also tested on spores killed by steam and on spores treated with ethylene oxide. We showed that EC determination could be used for a rapid control of the effectiveness of a disinfection ..
  28. [Allogeneic implantation of the tendon tissue sterilized with gaseous ethylene oxide in experiment]
    I A Kuznetsov
    Vestn Khir Im I I Grek 162:61-3
    The implantation of the allo-tendon tissue sterilized with gaseous ethylene oxide was carried out in 51 while rats...
  29. Decomposition of ethylene oxide in the RF plasma environment
    W T Liao
    Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan
    Environ Technol 22:165-73
    A radio frequency (RF) plasma system was used to decompose the ethylene oxide (EO) contained gas in the EO/Ar, and EO/O2/Ar system, respectively...
  30. Ethylene oxide gas sterilization: a simple technique for storing explanted skull bone. Technical note
    David H Jho
    Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Neurosurg 107:440-5
    The authors evaluated the effectiveness of a simple technique using ethylene oxide (EtO) gas sterilization and room temperature storage of autologous bone grafts for reconstructive cranioplasty following decompressive craniectomy...
  31. Ethylene oxide sterilization of autologous bone flaps following decompressive craniectomy
    P Missori
    Neurosurgery and Neurotraumatology, Neuroradiology II and Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Acta Neurochir (Wien) 145:899-902; discussion 902-3
    ..bone was firstly washed in hydrogen peroxide and then placed in hermetically-sealed bags and sterilized using ethylene oxide. The bone was repositioned after an average period of 4.3 months...
  32. Reprocessing of single-use endoscopic biopsy forceps and snares. One hospital's study
    D Hambrick
    Gastrointestinal Laboratory, Montclair Center for Digestive Diseases, Montclair Baptist Medical Center, 800 Montclair Road, Birmingham, AL 35213, USA
    Gastroenterol Nurs 24:112-5
    ..Reprocessing of the single-use devices tested did not result in endoscopic instruments that met acceptable standards for sterility at our institution...
  33. Use of peracetic acid to sterilize human donor skin for production of acellular dermal matrices for clinical use
    Qizhi Huang
    Medical Cryobiology Unit, Department of Biology, The University of York, York, United Kingdom
    Wound Repair Regen 12:276-87
    ..In a comparison of gamma-irradiation, glycerol, and ethylene oxide, sterilization with ethylene oxide after treatment with glycerol provided the most satisfactory dermis in ..
  34. Effect of ethylene oxide sterilization on enamel and dentin demineralization in vitro
    Renske Z Thomas
    Department of Dentistry and Dental Hygiene, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Dent 35:547-51
    ..The aim of this study was to assess the effect of sterilising sound human enamel and dentin with ethylene oxide on lesion depth and mineral loss before and after in vitro demineralization...
  35. OSHA compliance: issues ethylene oxide in a commercial sterilization operation
    George Daniel
    US Department of Labor, Occupational Safety and Health Administration, St Louis Area Office, St Louis, Missouri, USA
    J Occup Environ Hyg 1:D121-5
  36. Prepared endotracheal tubes: are they a potential source for pathogenic microorganisms?
    Nivez F Rasic
    Department of Anesthesia, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    Anesth Analg 97:1133-6, table of contents
    ..A stylet was inserted into a 7-mm ETT, and this system was ethylene oxide sterilized. The PETTs were placed in 20 different locations and sampled 8 times in a 4-wk period...
  37. Factors affecting tailing in ethylene oxide sterilization part 1: When tailing is an artifact... and scientific deficiencies in ISO 11135 and EN 550
    Gregg A Mosley
    Biotest Laboratories, Inc, Minneapolis, MN, USA
    PDA J Pharm Sci Technol 58:81-95
    ..Application of these methods will allow more accurate calculations of process lethality that are supported by biological data and appropriate mathematical analyses...
  38. Round-robin evaluation of a solid-phase microextraction-gas chromatographic method for reliable determination of trace level ethylene oxide in sterilized medical devices
    Thomas Harper
    Sterile Process Technologies SPT, a Division of the Johnson and Johnson Corp, Route 1 and Commerce Blvd, North Brunswick, NJ 08902, USA
    Biomed Chromatogr 22:136-48
    Medical devices that are sterilized with ethylene oxide (EtO) retain small quantities of EtO residuals, which may cause negative systemic and local irritating effects, and must be accurately quantified to ensure non-toxicity...
  39. Comparative sterilization effectiveness of plasma in O2-H2O2 mixtures and ethylene oxide treatment
    J M F Silva
    Laboratory of Medicine and Cosmetic Quality Control, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
    PDA J Pharm Sci Technol 61:204-10
    ..the influence of variable parameters of plasma sterilization and compared its effectiveness with that of ethylene oxide using a reactive ion etching plasma reactor at 13.56 MHz...
  40. Effect of polyoxypropylene chain length on the critical micelle concentration of propylene oxide-ethylene oxide block copolymers
    Zhi Guo Zhang
    Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci B 6:219-21
    ..The change in the work of cohesion per oxypropylene group when passing from molecular into micellar state, calculated from the Shinoda equation, was 0.43 kT for the studied compounds...
  41. [Influence of processing and sterilization on the mechanical properties of pins made from bovine cortical bone]
    C Hofmann
    Klinik für Unfall, Wiederherstellungs und Handchirurgie, Philipps Universität, Marburg
    Unfallchirurg 106:478-82
    ..three to five were treated with sodium chloride and acetone and afterwards sterilized by different means (ethylene oxide, autoclavation, or gamma radiation). All pins were subjected to a three-point-bending test and a shear test...
  42. Influence of lamella features of UHMWPE on its physical and uniaxial tensile properties. I. Effect of sterilization method in uncrosslinked and unaged materials
    Sanjay Mishra
    Department of Physics, The University of Memphis, Memphis, TN 38152, USA
    Biomed Mater Eng 13:135-46
    ..sterilization treatments (none, gamma-irradiation in air, gamma-irradiation in a nitrogen-rich atmosphere, ethylene oxide gas, and gas plasma) were determined...
  43. The performance of gamma- and EtO-sterilised UHWMPE acetabular cups tested under severe simulator conditions. Part 1: role of the third-body wear process
    S Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 23:4839-46
    ..In order to evaluate the influence of the sterilisation method (gamma-irradiation and ethylene oxide(EtO)-treatment) and third-body particles on the ultra-high-molecular-weight-polyethylene wear behaviour, gamma-..
  44. Effects of the sterilisation method on the wear of UHMWPE acetabular cups tested in a hip joint simulator
    S Affatato
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1439-46
    ..This study was performed to investigate the effects of the sterilisation method (gamma irradiation and ethylene oxide treatment) on the wear and on the changes in physical properties of polyethylene acetabular cups...
  45. The effects of ethylene oxide and gas-plasma sterilization on failure strength and failure mode of pre-tied monofilament ligature loops
    Steven S Trostle
    Department of Surgical Sciences, University of Wisconsin, WI, USA
    Vet Surg 31:281-4
    OBJECTIVE: To evaluate the effects of ethylene oxide and gas-plasma sterilization on the failure strength and failure mode of pre-tied monofilament ligature loops...
  46. Assessment of reprocessed arthroscopic shaver blades
    Jonathan S King
    Department of Orthopaedic Surgery, Loma Linda University, Loma Linda, California 92354, USA
    Arthroscopy 22:1046-52
    ..shaver blades that had been reprocessed with mechanical cleaning, functional testing, and sterilization with ethylene oxide. A spectrophotometer measured the amount of nucleic acid and protein...
  47. Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds
    Yuan Ji
    Department of Materials Science and Engineering, SUNY at Stony Brook, Stony Brook, NY 11794-2275, USA
    Biomaterials 27:3782-92
    ..In order to facilitate the fiber formation during electrospinning, Poly (ethylene oxide) (PEO) was added into the aqueous solution of HA-DTPH at an optimal weight ratio of 1:1...
  48. Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene
    M M Endo
    School of Mechanical Engineering, University of Leeds, UK
    Biomed Mater Eng 11:23-35
    ..vacuum gamma irradiated), GUR 1120 crosslinked (acetylene enhanced irradiated) and non cross linked (ethylene oxide sterilised) GUR 1020 UHMWPE was compared in multidirectional pin-on-plate wear tests under three different ..
  49. Low-shrinkage dental restorative composite: modeling viscoelastic behavior during setting
    Bibi S Dauvillier
    Department of Inorganic Chemistry and Catalysis, Debije Institute, Utrecht University, Sorbonnelaan 16, NL 3584 CA Utrecht, The Netherlands
    J Biomed Mater Res B Appl Biomater 73:129-39
    ..The setting behavior of an experimental oxirane composite has been investigated by analyzing stress-strain data with two-parametric mechanical models...
  50. Assessment of parameters associated to the risk of PVC catheter reuse
    D L Granados
    National University of San Juan, Institute of Chemical Engineering, Avenida San Martín 1109 Oeste (5400, San Juan, Argentina
    J Biomed Mater Res 58:505-10
    ..b>Ethylene oxide hospital-reprocessed central venous catheter samples were obtained from the stock of a health-care institution...
  51. Sterilization and strength of 70/30 polylactide cages: e-beam versus ethylene oxide
    Theo H Smit
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 32:742-7
    ..OBJECTIVE: To evaluate the effect of e-beam and ethylene oxide sterilization on degradation and strength...
  52. [Influence of sterilization treatments on continuous carbon-fiber reinforced polyolefin composite]
    Shi bing Guan
    Department of Orthopedic Surgery, Second Affiliated Hospital of Shandong University, Jinan, China
    Zhonghua Yi Xue Za Zhi 87:2228-31
    ..into 7 equal groups to undergo sterilization by autoclave, 2% glutaraldehyde soaking, 75% alcohol soaking, ethylene oxide sterilization, and Co-60 gamma ray irradiation of the dosages 11 kGy, 25 kGy, and 18 kGy respectively, and ..
  53. Purification of protein and recycling of polymers in a new aqueous two-phase system using two thermoseparating polymers
    J Persson
    Department of Biochemistry, Lund University, Sweden
    J Chromatogr A 864:31-48
    ..The polymers used in this work are EO50PO50, a random copolymer of 50% ethylene oxide (EO) and 50% propylene oxide (PO), and a hydrophobically modified random copolymer of EO and PO with aliphatic ..
  54. Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection
    Lev Bromberg
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Bioconjug Chem 16:626-33
    ..poly(2-N-(dimethylaminoethyl) methacrylate) (pDMAEMA) and copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO) has been developed...
  55. Block lengths and block sequence of linear triblock and glycerol derivative diblock copolyethers by electrospray ionization--collision-induced dissociation mass spectrometry
    Peran Terrier
    Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement, Université d'Evry-Val d'Essonne, CNRS UMR 8587, Bât. Maupertuis, Bd. F. Mitterrand, 91025 Evry Cedex, France
    Anal Chem 78:1801-6
    Chemical properties of ethylene oxide (EO) and propylene oxide (PO) block copolymers are strongly dependent on their sequence. Useful information about copolymer sequence can be obtained by tandem mass spectrometry (MS/MS)...
  56. Development of a bacteriophage model system to investigate virus inactivation methods used in the treatment of bone allografts
    Carol Bienek
    Protein Fractionation Centre, Scottish National Blood Transfusion Service, Ellen s Glen Road, Edinburgh, EH17 7QT, UK
    Cell Tissue Bank 8:115-24
    ..Two common sterilisation protocols applied to bone allografts are gamma irradiation and ethylene oxide gas sterilisation, and there are currently no validated models available for measuring the anti-viral efficacy ..
  57. Gamma irradiation and ethylene oxide in the sterilization of native reindeer bone morphogenetic protein extract
    T Pekkarinen
    Bone Transplantation Research Group, Department of Orthopaedic and Trauma Surgery, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Scand J Surg 94:67-70
    ..We compared the effects of ethylene oxide and gamma irradiation in the sterilization of native reindeer BMP extract with regard to bone induction in the ..
  58. Effects of ethylene oxide gas sterilization on physical properties of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) microspheres
    Y C Ah
    Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, Korea
    J Biomater Sci Polym Ed 12:783-99
    The aggregation of poly(alpha-hydroxy acid) microspheres during ethylene oxide (EO) gas sterilization makes it difficult for the microspheres to be used in clinical applications...
  59. Damage of office supply, personal use items, and over-the-counter medical devices after sterilization by ethylene oxide gas, electron beam, and gamma radiation
    Anne D Lucas
    U S Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD, USA
    Biomed Instrum Technol 38:476-84
    ..The effects of three sterilization methods (i.e. ethylene oxide gas [EO], electron beam [e-beam] radiation, and gamma radiation) were evaluated for a variety of office supply ..
  60. Exposure of hematopoietic stem cells to ethylene oxide during processing represents a potential carcinogenic risk for transplant recipients
    Byron E Butterworth
    Butterworth Consulting, 4820 Regalwood Dr, Raleigh, NC 27613, USA
    Regul Toxicol Pharmacol 49:149-53
    ..Sterilization of disposables with ethylene oxide is widespread, even though those sets unavoidably retain residual amounts of ethylene oxide which is a potent, ..
  61. Resterilization of instruments used in a hospital-based oral and maxillofacial surgery clinic
    Nicholas J V Hogg
    Department of Oral and Maxillofacial Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia
    J Can Dent Assoc 71:179-82
    ..Consideration should be given to the classification of certain types of dental burs as single-use devices if sterilization cannot be guaranteed...