Summary: Organic salts of cyanic acid containing the -OCN radical.

Top Publications

  1. Frick M, Björkner B, Hamnerius N, Zimerson E. Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate. Contact Dermatitis. 2003;48:305-9 pubmed
    ..Yet another patient, investigated in 1997 with suspected work-related contact dermatitis from the glue, is described. She, however, showed no positive reactions to any isocyanates. ..
  2. Gong X, Burbridge S, Cowley E, Linsdell P. Molecular determinants of Au(CN)(2)(-) binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl(-) channel pore. J Physiol. 2002;540:39-47 pubmed
    ..However, comparison of the effects of individual mutations on binding and selectivity suggest that these two aspects of the permeation mechanism are not strongly interdependent. ..
  3. Linsdell P, Gong X. Multiple inhibitory effects of Au(CN)(2-) ions on cystic fibrosis transmembrane conductance regulator Cl(-) channel currents. J Physiol. 2002;540:29-38 pubmed
    ..These results offer important caveats for the use of lyotropic pseudohalide anions such as Au(CN)(2-) as specific high affinity probes of Cl(-) channel pores. ..
  4. Tuominen J, Kylmä J, Kapanen A, Venelampi O, Itävaara M, Seppälä J. Biodegradation of lactic acid based polymers under controlled composting conditions and evaluation of the ecotoxicological impact. Biomacromolecules. 2002;3:445-55 pubmed
    ..All other polymers, including poly(ester-urethane) chain linked with 1,4-butane diisocyanate, showed no toxicological effect. ..
  5. Gong X, Linsdell P. Coupled movement of permeant and blocking ions in the CFTR chloride channel pore. J Physiol. 2003;549:375-85 pubmed
    ..We propose that multiple anions can bind simultaneously within the CFTR channel pore, and that repulsive interactions between bound anions speeds anion exit from the pore. ..
  6. Pronk A, Preller L, Raulf Heimsoth M, Jonkers I, Lammers J, Wouters I, et al. Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates. Am J Respir Crit Care Med. 2007;176:1090-7 pubmed
    ..Specific IgE was found in only a minority of symptomatic individuals. Specific IgG seems to be merely an indicator of exposure. ..
  7. Fent K, Jayaraj K, Ball L, Nylander French L. Quantitative monitoring of dermal and inhalation exposure to 1,6-hexamethylene diisocyanate monomer and oligomers. J Environ Monit. 2008;10:500-7 pubmed publisher
    ..This LC-MS method provides a valuable tool to investigate inhalation and dermal exposures to specific polyisocyanates and to explore relative differences in the exposure pathways. ..
  8. Gong X, Linsdell P. Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore. J Physiol. 2003;549:387-97 pubmed
    ..Binding to this site is also involved in coordination of multiple permeant anions within the pore, suggesting that anion binding in the outer mouth of the pore is an important aspect in the normal anion permeation mechanism. ..
  9. Pronk A, Yu F, Vlaanderen J, Tielemans E, Preller L, Bobeldijk I, et al. Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters. Occup Environ Med. 2006;63:624-31 pubmed
    ..Although (spray) painting with lacquers containing isocyanate hardeners results in the highest external exposures to HDI and oligomers, workers that do not perform paint related tasks may also receive a considerable internal dose. ..

More Information

Publications109 found, 100 shown here

  1. Wang Z, Nicholls S, Rodriguez E, Kummu O, Horkko S, Barnard J, et al. Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med. 2007;13:1176-84 pubmed
    ..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis. ..
  2. Donovan J, Kudla I, Dekoven J. Rapid development of allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate. Dermatitis. 2009;20:214-7 pubmed
    ..DMDI has strong sensitizing potential and requires rigorous safety monitoring in the workplace. ..
  3. Roberts J, Veres P, Cochran A, Warneke C, Burling I, Yokelson R, et al. Isocyanic acid in the atmosphere and its possible link to smoke-related health effects. Proc Natl Acad Sci U S A. 2011;108:8966-71 pubmed publisher
  4. Saxena A, Paul B, Sinha M, Dutta K, Das S, Ray P. A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacol Immunotoxicol. 1991;13:413-24 pubmed
    ..As the terminal differentiation process of B-cells were found equally affected in both PDC and NDMIC, it appears that MIC has no synergistic effect on the humoral immunity of the protein malnourished host. ..
  5. Piirilä P, Keskinen H, Luukkonen R, Salo S, Tuppurainen M, Nordman H. Work, unemployment and life satisfaction among patients with diisocyanate induced asthma--a prospective study. J Occup Health. 2005;47:112-8 pubmed
    ..Proper follow-up of asthma is essential for minimizing the social complaints of occupational asthma, as well as for enhancing life satisfaction. ..
  6. van Putten S, Wubben M, Hennink W, van Luyn M, Harmsen M. The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10. Biomaterials. 2009;30:730-5 pubmed publisher
    ..These results indicate that cmvIL-10 downmodulates the FBR, impairing the progression of the FBR. This study demonstrates the feasibility of interleukin-10 as a biomolecular tool in biomaterials for regenerative medicine...
  7. Hishiya T, Asanuma H, Komiyama M. Spectroscopic anatomy of molecular-imprinting of cyclodextrin. Evidence for preferential formation of ordered cyclodextrin assemblies. J Am Chem Soc. 2002;124:570-5 pubmed
    ..Direct spectroscopic evidence for molecular-imprinting effect has been obtained. Molecular imprinting of CyDs is potent for tailor-made preparation of synthetic receptors for nanometer-scaled guests. ..
  8. Lin M, Williams C, Murray M, Conn G, Ropp P. Ion chromatographic quantification of cyanate in urea solutions: estimation of the efficiency of cyanate scavengers for use in recombinant protein manufacturing. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;803:353-62 pubmed
    ..The pertinence of these approaches in preventing protein carbamylation during manufacturing are discussed. ..
  9. Jaisson S, Garnotel R, Gillery P. New evidence to support the clinical and biological relevance of the protein carbamylation process in human pathophysiology. Med Hypotheses. 2008;70:1070-1 pubmed publisher
  10. Eglin D, Griffon S, Alini M. Thiol-containing degradable poly(thiourethane-urethane)s for tissue engineering. J Biomater Sci Polym Ed. 2010;21:477-91 pubmed publisher
    ..The surface thiol groups add the prospect of further functionalization. This is an important benefit compared to biodegradable poly(urethane)s that usually present low biological activity. ..
  11. Brosse C, Soutif J, Brosse J. Preparation of microcapsules for skin allergy testing by the solvent evaporation process. J Microencapsul. 2000;17:111-6 pubmed
    ..The encapsulation yields, depending on the agent to be encapsulated, vary from 22 to 45%. ..
  12. Luque Almagro V, Blasco R, Fernández Romero J, de Castro M. Flow-injection spectrophotometric determination of cyanate in bioremediation processes by use of immobilised inducible cyanase. Anal Bioanal Chem. 2003;377:1071-8 pubmed
    ..Finally, the method was applied to different samples collected from the bioremediation tank using the standard addition method; recoveries between 85.9 and 97.4% were obtained...
  13. Henneken H, Hayen H, Vogel M, Karst U. Validation of a diffusive sampling method for airborne low-molecular isocyanates using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole-impregnated filters and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2006;1134:112-21 pubmed
    ..4 ppb for MIC and 1.3 ppb for EIC and PhIC applying 15 min sampling periods. Owing to high background signals, isocyanic acid could only be determined when it was present in concentrations in the high ppb range. ..
  14. Small W, Gjersing E, Herberg J, Wilson T, Maitland D. Magnetic resonance flow velocity and temperature mapping of a shape memory polymer foam device. Biomed Eng Online. 2009;8:42 pubmed publisher
    ..Though non-physiological conditions were used in this initial study, the utility of MRI in the development of a thermally-activated SMP foam device has been demonstrated. ..
  15. Ha E. Cyanate attenuates insulin secretion in cultured pancreatic ? cells. Mol Med Rep. 2012;5:1461-4 pubmed publisher
    ..The inhibitory effect was not mediated either by ROS generation or by apoptosis. Further studies to determine the underlying mechanisms will be of benefit. ..
  16. Bjorkner B, Bruze M, Moller H. High frequency of contact allergy to gold sodium thiosulfate. An indication of gold allergy?. Contact Dermatitis. 1994;30:144-51 pubmed
    ..Our findings make gold sodium thiosulfate the 2nd most common contact allergen after nickel sulfate. It is suggested that a positive skin test to gold sodium thiosulfate represents gold allergy...
  17. Mun K, Golper T. Impaired biological activity of erythropoietin by cyanate carbamylation. Blood Purif. 2000;18:13-7 pubmed
    ..Targeting dialysis doses specifically to urea concentrations may be more important than previously considered. ..
  18. Mitome H, Shirato N, Miyaoka H, Yamada Y, van Soest R. Terpene isocyanides, isocyanates, and isothiocyanates from the Okinawan marine sponge Stylissa sp. J Nat Prod. 2004;67:833-7 pubmed
    ..along with 12 known related compounds. Structural determinations of these compounds were made by spectroscopic analysis, and assessment was made of their cytotoxicity toward HeLa cells. ..
  19. Miao Q, Xu J, Lin A, Wu X, Wu L, Xie W. Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents. Curr Med Chem. 2017;: pubmed publisher
    ..In the past several decades, different kinds of organoselenium compounds, such as selenides, seleno(iso)cyanates, substituted selenoureas, selenious esters and Se-containing heterocycles have been reported as candidates of ..
  20. Sastre J, Banks D, Lopez M, Barkman H, Salvaggio J. Neutrophil chemotactic activity in toluene diisocyanate (TDI)-induced asthma. J Allergy Clin Immunol. 1990;85:567-72 pubmed
    ..These observations support the hypothesis that activation of mast cells or basophils is associated with TDI-induced early and late asthmatic reaction. ..
  21. Ekman J, Levin J, Lindahl R, Sundgren M, Ostin A. Comparison of sampling methods for 1,6-hexamethylene diisocyanate, (HDI) in a commercial spray box. Analyst. 2002;127:169-73 pubmed
    ..No significant difference was found between the three methods using ANOVA with a significance level of alpha = 0.05. ..
  22. Pauluhn J. Acute inhalation studies with irritant aerosols: technical issues and relevance for risk characterization. Arch Toxicol. 2004;78:243-51 pubmed
  23. Gu W, Ma Y, Zhu C, Chen B, Ma J, Gao H. Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin. Eur J Pharm Sci. 2012;47:556-63 pubmed publisher
  24. Carr R, Foster R, Freitag D, Pasutto F. Stereospecific high-performance liquid chromatographic determination of tocainide. J Chromatogr. 1991;566:155-62 pubmed
    ..25-10.0 mg/l for each enantiomer in plasma (r2 greater than 0.998). The inter-assay variability was less than 10% at all concentrations examined. The method can be used to determine the pharmacokinetics of tocainide enantiomers in man. ..
  25. van Putten S, Wübben M, Plantinga J, Hennink W, van Luyn M, Harmsen M. Endotoxin contamination delays the foreign body reaction. J Biomed Mater Res A. 2011;98:527-34 pubmed publisher
    ..This finding indicates that endotoxin contamination has significant implications for the in vivo function of biomaterials and medical devices and emphasizes the importance of endotoxin testing. ..
  26. Tsui G, Ninnemann N, Hosotani A, Lautens M. Expedient synthesis of chiral oxazolidinone scaffolds via rhodium-catalyzed asymmetric ring-opening with sodium cyanate. Org Lett. 2013;15:1064-7 pubmed publisher
  27. Wang X, Zhang J, Cheng R, Meng F, Deng C, Zhong Z. Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent. Biomacromolecules. 2016;17:882-90 pubmed publisher
    ..Hence, cystamine diisocyanate appears to be an innovative coupling agent that facilitates versatile synthesis of biocompatible and reductively degradable biopolymers. ..
  28. Tang Y, Labow R, Santerre J. Enzyme induced biodegradation of polycarbonate-polyurethanes: dose dependence effect of cholesterol esterase. Biomaterials. 2003;24:2003-11 pubmed
    ..The role of protein binding in modulating the hydrolytic action of the enzymes at different activity levels highlights a need for further study in this area. ..
  29. Kuo M, Chen H, Chao I. Cyanation: providing a three-in-one advantage for the design of n-type organic field-effect transistors. Chemistry. 2007;13:4750-8 pubmed
    ..They have the potential to outperform N-fluoroalkylated dicyanoperylene-3,4:9,10-bis(dicarboximides) (PDI-FCN(2)) in terms of electron mobility. ..
  30. Schaller H, Schmidhammer U, Riedle E, Mayr H. Ambident reactivity of the cyanate anion. Chemistry. 2008;14:3866-8 pubmed publisher
  31. Mokso R, Møllendal H, Guillemin J. A microwave spectroscopic and quantum chemical study of propa-1,2-dienyl selenocyanate (H(2)==C==CHSeC[triple bond]N) and cyclopropyl selenocyanate (C(3)H(5)SeC[triple bond]N). Phys Chem Chem Phys. 2008;10:4138-46 pubmed publisher
    ..The microwave study has been augmented by quantum chemical calculations at the B3LYP/6-311+ +G(3df,3pd) and MP2/6-311+ +G(3df,3pd) levels of theory. ..
  32. Yu S, Su S, Dorenkamp Y, Wodtke A, Dai D, Yuan K, et al. Competition between direct and indirect dissociation pathways in ultraviolet photodissociation of HNCO. J Phys Chem A. 2013;117:11673-8 pubmed publisher
    ..67 nm photolysis. Vibrational structures are observed in both direct and indirect dissociation pathways, which can be assigned to the NCO bending mode excitation with some stretching excitation. ..
  33. Martin S, Harding J. Site of carbamoylation of bovine gamma-II-crystallin by potassium [14C]cyanate. Biochem J. 1989;262:909-15 pubmed
    ..It appears that the alpha-amino group of the N-terminal glycine was the main site of carbamoylation. This site forms part of the charge network on the surface of gamma-II-crystallin...
  34. Wiethege T, Potthast J, Marczynski B, Marek W, Voss B, Baur X. [Induction of rat liver foci by inhaled diisocyanate exposure]. Pneumologie. 1995;49:373-7 pubmed
    ..3 +/- 3.2 and 1.8 +/- 1.4 respectively). In none of the animals exposed to TDI or HDI preneoplastic foci were detectable.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  35. Park K, Mun K, Chang E, Park S, Kim H. Inhibition of erythropoietin activity by cyanate. Scand J Urol Nephrol. 2004;38:69-72 pubmed
    ..C-EPO and high urea-derived cyanate levels may contribute to suboptimal erythropoietic responses to EPO therapy for chronic renal failure and ESRD, and may provide another measurement indicating inadequate dialysis. ..
  36. Narla S, Sun X. Orientated glyco-macroligand formation based on site-specific immobilization of O-cyanate chain-end functionalized glycopolymer. Org Biomol Chem. 2011;9:845-50 pubmed publisher
    ..In addition, the O-cyanate chain-end functionalized glycopolymer can also be used for site-specific polymer-protein conjugation. ..
  37. Chan Chan L, Vargas Coronado R, Cervantes Uc J, Cauich Rodríguez J, Rath R, Phelps E, et al. Platelet adhesion and human umbilical vein endothelial cell cytocompatibility of biodegradable segmented polyurethanes prepared with 4,4'-methylene bis(cyclohexyl isocyanate), poly(caprolactone) diol and butanediol or dithioerythritol as chain extend. J Biomater Appl. 2013;28:270-7 pubmed publisher
    ..These biodegradable segmented polyurethanes represent promising materials for cardiovascular applications. ..
  38. Bousová K, Krcmova I. [Diisocyanate exposure as a cause of occupational asthma]. Acta Medica (Hradec Kralove) Suppl. 2004;47:35-40 pubmed
  39. Fent K, Jayaraj K, Gold A, Ball L, Nylander French L. Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate. Scand J Work Environ Health. 2006;32:225-40 pubmed
    ..This study demonstrates that HDI on skin can be collected with tape-strips and quantified at occupational levels using LC-MS. ..
  40. Chuang T, Chen M, Lin F. Preparation and surface characterization of HMDI-activated 316L stainless steel for coronary artery stents. J Biomed Mater Res A. 2008;85:722-30 pubmed
    ..89 micromol/cm(2) amine group. We conclude that the HMDI-activated surface has more desirable surface characteristics than the APTS-activated surface has, such as chemical stability and the amount of active amine groups. ..
  41. Bindschedler S, Vu Bouquet T, Job D, Joseph E, Junier P. Fungal Biorecovery of Gold From E-waste. Adv Appl Microbiol. 2017;99:53-81 pubmed publisher
  42. Alexandersson R, Hedenstierna G, Plato N, Kolmodin Hedman B. Exposure, lung function, and symptoms in car painters exposed to hexamethylendiisocyanate and biuret modified hexamethylendiisocyanate. Arch Environ Health. 1987;42:367-73 pubmed
    ..Car platers did not differ from controls. ..
  43. Redlich C, Stowe M, Coren B, Wisnewski A, Holm C, Cullen M. Diisocyanate-exposed auto body shop workers: a one-year follow-up. Am J Ind Med. 2002;42:511-8 pubmed
  44. Holzer M, Gauster M, Pfeifer T, Wadsack C, Fauler G, Stiegler P, et al. Protein carbamylation renders high-density lipoprotein dysfunctional. Antioxid Redox Signal. 2011;14:2337-46 pubmed publisher
    ..The present results raise the possibility that HDL carbamylation contributes to foam cell formation in atherosclerotic lesions. ..
  45. Flack S, Fent K, Gaines L, Thomasen J, Whittaker S, Ball L, et al. Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate. Biomarkers. 2011;16:261-70 pubmed publisher
    ..3, p?<?0.06) than same day exposure (p???0.13) indicates long-term elimination kinetics for HDA-Hb adducts. This association demonstrates the suitability of HDA-Hb adducts for further validation as a biomarker of HDI exposure. ..
  46. Wang T, Zhang L, Li D, Yin J, Wu S, Mao Z. Mechanical properties of polyurethane foams prepared from liquefied corn stover with PAPI. Bioresour Technol. 2008;99:2265-8 pubmed
    ..8, and then declined; while the elongation at break decreased from 117% to 3.6%. The results indicated that by changing the [NCO]/[OH] ratio, mechanical properties of LCS-PU foams could be adjusted for various end uses. ..
  47. Flack S, Fent K, Trelles Gaines L, Thomasen J, Whittaker S, Ball L, et al. Quantitative plasma biomarker analysis in HDI exposure assessment. Ann Occup Hyg. 2010;54:41-54 pubmed publisher
    ..These findings indicate that HDA concentration in hydrolyzed plasma may be used as a biomarker of cumulative inhalation and dermal exposure to HDI and for investigating the effectiveness of exposure controls in the workplace. ..
  48. Roy S, Ghosh P, Sk U, Chakraborty P, Biswas J, Mandal S, et al. Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy. Bioorg Med Chem Lett. 2010;20:6951-5 pubmed publisher
    ..w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels. ..
  49. Wisnewski A, Redlich C. Recent developments in diisocyanate asthma. Curr Opin Allergy Clin Immunol. 2001;1:169-75 pubmed
    ..A better understanding of the pathogenesis of diisocyanate asthma should facilitate the development of better diagnostic tests and strategies for disease surveillance and intervention. ..
  50. Wisnewski A, Stowe M, Nerlinger A, Opare Addo P, Decamp D, Kleinsmith C, et al. Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG. Ann Occup Hyg. 2012;56:901-10 pubmed publisher
    ..The approach may also be applicable to evaluating isocyanate exposures in other settings, and may extend to other chemical allergens. ..
  51. Guilloton M, Lamblin A, Kozliak E, Gerami Nejad M, Tu C, Silverman D, et al. A physiological role for cyanate-induced carbonic anhydrase in Escherichia coli. J Bacteriol. 1993;175:1443-51 pubmed
  52. Blum T, Ermert J, Coenen H. No-carrier-added synthesis of aliphatic and aromatic radioselenoethers via selenocyanates. Nucl Med Biol. 2003;30:361-7 pubmed
    ..This is the first method described to obtain n.c.a. arylselenoethers. ..
  53. Schock S, Munyao N, Yakubchyk Y, Sabourin L, Hakim A, Ventureyra E, et al. Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance. Brain Res. 2007;1168:129-38 pubmed
    ..The results are consistent with the proposal that CSD releases ATP into the extracellular space and the subsequent activation of P2Y receptors makes a major contribution to the induction of ischemic tolerance in the brain. ..
  54. Luque Almagro V, Huertas M, Sáez L, Luque Romero M, Moreno Vivián C, Castillo F, et al. Characterization of the Pseudomonas pseudoalcaligenes CECT5344 Cyanase, an enzyme that is not essential for cyanide assimilation. Appl Environ Microbiol. 2008;74:6280-8 pubmed publisher
  55. Chan Chan L, Solis Correa R, Vargas Coronado R, Cervantes Uc J, Cauich Rodríguez J, Quintana P, et al. Degradation studies on segmented polyurethanes prepared with HMDI, PCL and different chain extenders. Acta Biomater. 2010;6:2035-44 pubmed publisher
    ..The formation of the porous structure on BSPU1 was observed by SEM, while a granular surface was observed on BSPU2 after alkaline degradation. ..
  56. Jaisson S, Pietrement C, Gillery P. Carbamylation-derived products: bioactive compounds and potential biomarkers in chronic renal failure and atherosclerosis. Clin Chem. 2011;57:1499-505 pubmed publisher
    ..Their use in clinical practice must still be validated by appropriate clinical studies. ..
  57. Thomasen J, Nylander French L. Penetration patterns of monomeric and polymeric 1,6-hexamethylene diisocyanate monomer in human skin. J Environ Monit. 2012;14:951-60 pubmed publisher
    ..A critical need exists to monitor dermal exposure quantitatively in exposed workers, to use proper protective equipment to reduce dermal exposure, and to re-evaluate regulatory exposure limits for isocyanates. ..
  58. Anderson P. Purification and properties of the inducible enzyme cyanase. Biochemistry. 1980;19:2882-8 pubmed
    ..6 mM. The initial product of the reaction is carbamate (or a related, unstable compound and/or carbamate precursor) which subsequently decomposes to ammonia and bicarbonate. ..
  59. Matsuno Yagi A, Hatefi Y. Ubiquinol:cytochrome c oxidoreductase (complex III). Effect of inhibitors on cytochrome b reduction in submitochondrial particles and the role of ubiquinone in complex III. J Biol Chem. 2001;276:19006-11 pubmed
    ..It was also shown that antimycin did not inhibit electron transfer from b (b(H)) to Q, in clear contrast to the assumption of the Q-cycle hypothesis regarding the site of antimycin inhibition. ..
  60. Sk U, Sharma A, Ghosh S, Bhattacharya S. Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,3'-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice. Eur J Med Chem. 2010;45:3265-73 pubmed publisher
    ..Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds, 6d being the most active one (6d>6c>6b>6a). ..
  61. Kassa R, Kasensa N, Monterroso V, Kayton R, Klimek J, David L, et al. On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure. Food Chem Toxicol. 2011;49:571-8 pubmed publisher
    ..g. protein disulfide isomerase), and maintenance of the cytoskeleton integrity (e.g. ?-spectrin). Studies are needed to elucidate the role of the aformentioned modifications in the pathogenesis of cassava-associated motor-system disease...
  62. Chalagalla S, Wang Y, Ray D, Zeng X, Perera I, Sun X. Synthesis and characterization of oriented glyco-capturing macroligand. Chembiochem. 2010;11:2018-25 pubmed publisher
  63. Nagarajan S, Reddy B, Tsibouklis J. In vitro effect on cancer cells: synthesis and preparation of polyurethane membranes for controlled delivery of curcumin. J Biomed Mater Res A. 2011;99:410-7 pubmed publisher
    ..The biocompatibility of these PU membranes was indicated by in vitro cytotoxicity studies using 3T3-L1-murine fibroblast cell. The in vitro therapeutic potential of the patches was demonstrated against A549 human lung cancer cells. ..
  64. Chen Y, Wu H, Sun J, Dong G, Wang T. Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery. Langmuir. 2013;29:3721-9 pubmed publisher
    ..The injectable thermoresponsive nanocomposite hydrogel system was biocompatible and degradable and had the slow controlled release property for anticancer drugs with potential applications in the field of drug delivery. ..
  65. Wank S, Jensen R, Gardner J. Kinetics of binding of cholecystokinin to pancreatic acini. Am J Physiol. 1988;255:G106-12 pubmed
    ..Computer analysis of the inhibition of 125I-CCK-8 by CCK-8 under experimental conditions where the rapidly dissociating state predominates demonstrated a complete loss of high-affinity binding sites.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  66. Bassey M, Etuk E, Ibe M, Ndon B. Diplazium sammatii: Athyraceae ('Nyama idim'): age-related nutritional and antinutritional analysis. Plant Foods Hum Nutr. 2001;56:7-12 pubmed
    ..3 mg/100 g dry matter, in young leaves. Oxalate levels were slightly higher in younger than older leaves. However, the reverse was true for tannin content. Both antinutritional compounds were present in levels which should be safe. ..
  67. Bernstein D, Ott M, Woolhiser M, Lummus Z, Graham C. Evaluation of antibody binding to diisocyanate protein conjugates in a general population. Ann Allergy Asthma Immunol. 2006;97:357-64 pubmed
    ..These antibody measurements may not be reliable indicators of diisocyanate exposure in nonoccupational populations and should not be interpreted as surrogates of diisocyanate exposure in the absence of defined referent populations. ..
  68. Yangyuoru P, Webb J, Shaw C. Proton-linked bi- and tri-metallic gold cyanide complexes observed by ESI-MS spectrometry. J Inorg Biochem. 2008;102:576-83 pubmed publisher
    ..Concentration-dependent studies demonstrated that the signals are independent of the solution concentrations of mono-metallic precursors, suggesting formation in the gas phase during or following droplet desolvation. ..
  69. Pauluhn J. Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate-polyisocyanate aerosols. Toxicology. 2008;247:33-45 pubmed publisher
    ..In summary, this study supports the conclusion that data from rat inhalation studies with these types of isocyanates appear to be more conservative and less variable than the respective data from mice. ..
  70. Wisnewski A, Srivastava R, Herick C, Xu L, Lemus R, Cain H, et al. Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am J Respir Crit Care Med. 2000;162:2330-6 pubmed
  71. Frija L, Reva I, Gomez Zavaglia A, Cristiano M, Fausto R. Photochemistry and vibrational spectra of matrix-isolated 5-ethoxy-1-phenyl-1H-tetrazole. J Phys Chem A. 2007;111:2879-88 pubmed
    ..This species has not been described before and is now characterized by infrared spectroscopy for the first time. ..
  72. Cruz J, Machado B. GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats. Auton Neurosci. 2009;146:47-55 pubmed publisher
    ..The results also show that Glutamate receptors in the PVN are not involved in maintenance of the baseline MAP, HR or in the cardiovascular responses to chemoreflex in awake rats. ..
  73. Claffey J, Deally A, Gleeson B, Hogan M, Méndez L, Müller Bunz H, et al. Pseudo-halide derivatives of titanocene: synthesis and cytotoxicity studies. Metallomics. 2009;1:511-7 pubmed publisher
    ..All four titanocene derivatives show significant cytotoxicity improvement when compared to unsubstituted titanocene dichloride and and showed similiar cytotoxic behaviour to Titanocene in vitro...
  74. El Gamal D, Holzer M, Gauster M, Schicho R, Binder V, Konya V, et al. Cyanate is a novel inducer of endothelial icam-1 expression. Antioxid Redox Signal. 2012;16:129-37 pubmed publisher
    ..Collectively, our data raise the possibility that cyanate amplifies vascular inflammation, linking inflammation, smoking, and uremia. ..
  75. Campiñez M, Aguilar de Leyva A, Ferris C, de Paz M, Galbis J, Caraballo I. Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery. Drug Dev Ind Pharm. 2013;39:1758-64 pubmed publisher
    ..It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release. ..
  76. Ishikawa S, Suyama K. Recovery and refining of Au by gold-cyanide ion biosorption using animal fibrous proteins. Appl Biochem Biotechnol. 1998;70-72:719-28 pubmed
    ..In column procedure, ESM packed on column removed gold-cyanide ion from the dilute aqueous solution to extremely low concentrations (nondetectable concentration of below 1 ppb). ..
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