oxaloacetic acid


Summary: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.

Top Publications

  1. Shilo M. The enzymic conversion of the tartaric acids to oxaloacetic acid. J Gen Microbiol. 1957;16:472-81 pubmed
  2. ABDEL TAWAB G, Broda E, Kellner G. The production of pyruvic acid, oxaloacetic acid and alpha-oxoglutaric acid from glucose by tissue in culture. Biochem J. 1959;72:619-23 pubmed
  3. Abrego J, Gunda V, Vernucci E, Shukla S, King R, Dasgupta A, et al. GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. Cancer Lett. 2017;400:37-46 pubmed publisher
    ..Thus, GOT1 plays an important role in energy metabolism and ROS balance in chronic acidosis stress. Our studies suggest that targeting anaplerotic glutamine metabolism may serve as an important therapeutic target in PDAC. ..
  4. Boyle N, Sengupta N, Morgan J. Metabolic flux analysis of heterotrophic growth in Chlamydomonas reinhardtii. PLoS ONE. 2017;12:e0177292 pubmed publisher
    ..When compared to predictions by flux balance analysis, fluxes measured with 13C-MFA were found to be suboptimal with respect to biomass yield; C. reinhardtii sacrifices biomass yield to produce ATP and reducing equivalents. ..
  5. Małecki J, Jakobsson M, Ho A, Moen A, Rustan A, Falnes P. Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. J Biol Chem. 2017;292:17950-17962 pubmed publisher
    ..Based on the established naming nomenclature for similar enzymes, we suggest that METTL12 be renamed CS-KMT (gene name CSKMT). ..