aminolevulinic acid


Summary: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.

Top Publications

  1. Zhao S, Wu J, Wang C, Liu H, Dong X, Shi C, et al. Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies. PLoS ONE. 2013;8:e63682 pubmed publisher
    We performed a systematic review and meta-analysis to address the (added) value of intraoperative 5-aminolevulinic acid (5-ALA)-guided resection of high-grade malignant gliomas compared with conventional neuronavigation-guided resection, ..
  2. Dirschka T, Radny P, Dominicus R, Mensing H, Bruning H, Jenne L, et al. Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo. Br J Dermatol. 2012;166:137-46 pubmed publisher
    ..BF-200 ALA is a very effective, well-tolerated new formulation for AK treatment with PDT and is superior to a registered MAL medication. Efficacies and adverse events vary greatly with the different light sources used. ..
  3. Christensen E, Mørk C, Skogvoll E. High and sustained efficacy after two sessions of topical 5-aminolaevulinic acid photodynamic therapy for basal cell carcinoma: a prospective, clinical and histological 10-year follow-up study. Br J Dermatol. 2012;166:1342-8 pubmed publisher
    ..The only lesion larger than 2·0 cm relapsed. Two sessions of DMSO-supported topical ALA-PDT and curettage can provide long-term effective treatment results with favourable cosmetic outcome in primary, small BCC. ..
  4. Anand S, Ortel B, Pereira S, Hasan T, Maytin E. Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Lett. 2012;326:8-16 pubmed publisher
    ..An emerging biomodulatory approach, using methotrexate or Vitamin D in combination with aminolevulinate-based PDT, is described. Finally, current clinical uses of PDT for solid malignancies are reviewed. ..
  5. Tsugu A, Ishizaka H, Mizokami Y, Osada T, Baba T, Yoshiyama M, et al. Impact of the combination of 5-aminolevulinic acid-induced fluorescence with intraoperative magnetic resonance imaging-guided surgery for glioma. World Neurosurg. 2011;76:120-7 pubmed publisher
    To compare intraoperative magnetic resonance imaging (MRI)-guided resection with resection guided by 5-aminolevulinic acid (5-ALA)-induced fluorescence in patients with gliomas and to evaluate the impact of intraoperative MRI in glioma ..
  6. Liu B, Farrell T, Patterson M. Comparison of noninvasive photodynamic therapy dosimetry methods using a dynamic model of ALA-PDT of human skin. Phys Med Biol. 2012;57:825-41 pubmed publisher
    ..The AFBM was less sensitive to treatment conditions but CSOL demonstrated the best overall performance...
  7. Nicolodelli G, Kurachi C, Rego R, Omairi T, Bagnato V. Evidence of 5-aminolevulinic acid (ALA) penetration increase due to microdrilling in soft tissue using femtosecond laser ablation. Lasers Med Sci. 2012;27:1067-71 pubmed publisher
    ..One of the main limitations of PDT using 5-aminolevulinic acid (ALA) is the superficial volume of treatment, mainly due to the limited penetration of topical ..
  8. Kamp M, Grosser P, Felsberg J, Slotty P, Steiger H, Reifenberger G, et al. 5-aminolevulinic acid (5-ALA)-induced fluorescence in intracerebral metastases: a retrospective study. Acta Neurochir (Wien). 2012;154:223-8; discussion 228 pubmed publisher
    ..We were interested in the potential impact of 5-aminolevulinic acid (5-ALA)-induced-fluorescence (5-AIF) as a diagnostic tool for the resection of intracerebral metastases...
  9. Panciani P, Fontanella M, Schatlo B, Garbossa D, Agnoletti A, Ducati A, et al. Fluorescence and image guided resection in high grade glioma. Clin Neurol Neurosurg. 2012;114:37-41 pubmed publisher
    ..Thus, the use of auxiliary techniques should always be subject to critical skills of the surgeon. We advocate a large-scale study to further improve the assessment of multimodal approaches. ..

More Information


  1. Roberts D, Valdes P, Harris B, Hartov A, Fan X, Ji S, et al. Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid). Neurosurg Clin N Am. 2012;23:371-7 pubmed publisher
    5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope...
  2. Etminan N, Peters C, Lakbir D, Bünemann E, Börger V, Sabel M, et al. Heat-shock protein 70-dependent dendritic cell activation by 5-aminolevulinic acid-mediated photodynamic treatment of human glioblastoma spheroids in vitro. Br J Cancer. 2011;105:961-9 pubmed publisher
    ..Here, we have studied the effect of 5-aminolevulinic acid (ALA)-mediated PDT on DCs in vitro in a human spheroid model of glioblastoma (GB)...
  3. Kang Z, Zhang J, Zhou J, Qi Q, Du G, Chen J. Recent advances in microbial production of ?-aminolevulinic acid and vitamin B12. Biotechnol Adv. 2012;30:1533-42 pubmed publisher
    ..Furthermore, the direction for future research and perspective are also summarized. ..
  4. Inoue K, Fukuhara H, Shimamoto T, Kamada M, Iiyama T, Miyamura M, et al. Comparison between intravesical and oral administration of 5-aminolevulinic acid in the clinical benefit of photodynamic diagnosis for nonmuscle invasive bladder cancer. Cancer. 2012;118:1062-74 pubmed publisher evaluate the clinical value of photodynamic diagnosis (PDD) with intravesical and oral instillation of 5-aminolevulinic acid (ALA) (ALA-PDD), and transurethral resection of bladder tumor (TURBT) guided by ALA-PDD (PDD-TURBT) for ..
  5. Murayama Y, Ichikawa D, Koizumi N, Komatsu S, Shiozaki A, Kuriu Y, et al. Staging fluorescence laparoscopy for gastric cancer by using 5-aminolevulinic acid. Anticancer Res. 2012;32:5421-7 pubmed
    Precise staging of gastric cancer is essential when selecting for the appropriate treatment approach. 5-Aminolevulinic acid (5-ALA) is metabolized and accumulated as protoporphyrin IX (PpIX), which is a photosensitizer...
  6. Widhalm G, Minchev G, Woehrer A, Preusser M, Kiesel B, Furtner J, et al. Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies. Neurosurg Rev. 2012;35:381-91; discussion 391 pubmed publisher
    ..Five-aminolevulinic acid (5-ALA) has been shown to accumulate in malignant tumor tissue...
  7. Sakamoto F, Doukas A, Farinelli W, Tannous Z, Su Y, Smith N, et al. Intracutaneous ALA photodynamic therapy: dose-dependent targeting of skin structures. Lasers Surg Med. 2011;43:621-31 pubmed publisher
    Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) depends on local drug uptake, metabolism to porphyrins, and depth of light penetration using different wavelengths. Topical ALA-PDT has limited depth of drug penetration...
  8. Hatakeyama T, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Ikoma H, et al. Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes in human colon cancer cells. Oncol Rep. 2013;29:911-6 pubmed publisher
    5-Aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) is a highly selective treatment for malignant cells...
  9. Kobuchi H, Moriya K, Ogino T, Fujita H, Inoue K, Shuin T, et al. Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation. PLoS ONE. 2012;7:e50082 pubmed publisher
    Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy...
  10. Kim C, Chung C, Choi K, Yoo J, Kim D, Jeong Y, et al. Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells. Int J Nanomedicine. 2011;6:1357-63 pubmed publisher
    ..exhibit an enhanced capacity for protoporphyrin IX (PpIX) synthesis facilitated by the administration of 5-aminolevulinic acid (ALA)...
  11. Gholam P, Weberschock T, Denk K, Enk A. Treatment with 5-aminolaevulinic acid methylester is less painful than treatment with 5-aminolaevulinic acid nanoemulsion in topical photodynamic therapy for actinic keratosis. Dermatology. 2011;222:358-62 pubmed publisher
    ..001) and a significantly (p < 0.05) lower number of treatment interruptions. Differences in selectivity for tumour cells and transport of ALA in peripheral neurons may play a role. ..
  12. Schucht P, Beck J, Abu Isa J, Andereggen L, Murek M, Seidel K, et al. Gross total resection rates in contemporary glioblastoma surgery: results of an institutional protocol combining 5-aminolevulinic acid intraoperative fluorescence imaging and brain mapping. Neurosurgery. 2012;71:927-35; discussion 935-6 pubmed publisher
    ..To evaluate the impact of using 5-aminolevulinic acid and intraoperative mapping and monitoring on the rate of complete resection of enhancing tumor (CRET), ..
  13. Buinauskaite E, Maciulaitis R, Buinauskiene J, Valiukeviciene S. Topical photodynamic therapy of actinic keratoses with 5-aminolevulinic acid: randomized controlled trial with six months follow-up. J Dermatolog Treat. 2014;25:519-22 pubmed publisher
    Topical 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) is an effective treatment for actinic keratosis (AK) with some transient adverse events...
  14. Liu B, Farrell T, Patterson M. Comparison of photodynamic therapy with different excitation wavelengths using a dynamic model of aminolevulinic acid-photodynamic therapy of human skin. J Biomed Opt. 2012;17:088001-1 pubmed publisher
    ..Clinical studies show inconsistent results for the effectiveness of aminolevulinic acid (ALA)-PDT performed at different wavelengths...
  15. Teper E, Makhov P, Golovine K, Canter D, Myers C, Kutikov A, et al. The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells. Urology. 2012;80:1391.e1-7 pubmed publisher
    ..A precursor of the heme synthetic pathway, 5-aminolevulinic acid, is metabolized to protoporphyrin IX, which is highly reactive with zinc...
  16. Ahmad S, Aboumarzouk O, Somani B, Nabi G, Kata S. Oral 5-aminolevulinic acid in simultaneous photodynamic diagnosis of upper and lower urinary tract transitional cell carcinoma - a prospective audit. BJU Int. 2012;110:E596-600 pubmed publisher
    ..5-Aminolevulinic acid (5-ALA) was first suggested for photodynamic diagnosis (PDD) of transitional cell cancer (TCC) of the ..
  17. Yoon J, Yoon H, Kim O, Kim S, Ahn S, Kang K. The enhanced anti-cancer effect of hexenyl ester of 5-aminolaevulinic acid photodynamic therapy in adriamycin-resistant compared to non-resistant breast cancer cells. Lasers Surg Med. 2012;44:76-86 pubmed publisher
    ..These findings suggest that ALA-hx PDT may be usable as a therapeutic alternative for adriamycin-resistant breast cancer. ..
  18. Nokes B, Apel M, Jones C, Brown G, Lang J. Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications. J Surg Res. 2013;181:262-71 pubmed publisher
    b>Aminolevulinic acid (ALA) is a heme precursor that may have potential applications for photodynamic detection and photodynamic therapy-based treatment of solid tumors in a variety of malignancies...
  19. von Campe G, Moschopulos M, Hefti M. 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies. Acta Neurochir (Wien). 2012;154:585-8; discussion 588 pubmed publisher
    ..This in turn increases the risk of hemorrhagic complications. We present the use of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX fluorescence in frameless stereotaxy to improve the procedure duration ..
  20. Fabricius S, Lerche C, Philipsen P, Wulf H. The relation between methyl aminolevulinate concentration and inflammation after photodynamic therapy in healthy volunteers. Photochem Photobiol Sci. 2013;12:117-23 pubmed publisher
    ..0005). Pain and post-treatment hyperpigmentation can be reduced but not eliminated by limiting the MAL concentration. An efficacy study of PDT with these three reduced concentrations has not been performed. ..
  21. Koizumi N, Harada Y, Murayama Y, Harada K, Beika M, Yamaoka Y, et al. Detection of metastatic lymph nodes using 5-aminolevulinic acid in patients with gastric cancer. Ann Surg Oncol. 2013;20:3541-8 pubmed publisher
    ..In this study, we focused on a known photosensitizer, 5-aminolevulinic acid (5-ALA), and examined the feasibility of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence to detect ..
  22. Baglo Y, Gabrielsen M, Sylte I, Gederaas O. Homology modeling of human ?-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy. PLoS ONE. 2013;8:e65200 pubmed publisher
    ..In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer ..
  23. Johnson R, Chung C, Jeong Y, Kang D, Suh H, Kim I. Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy. Int J Nanomedicine. 2012;7:2497-512 pubmed publisher
    5-Aminolevulinic acid (ALA) and its derivatives have been widely used in photodynamic therapy...
  24. Novak B, Schulten R, Lubbert H. ?-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:583-602 pubmed publisher
    Application of ?-aminolevulinic acid (ALA) or its methyl ester (MAL) onto cutaneous tumours increases intracellular Protoporphyrin IX (PpIX), serving as photosensitizer in photodynamic therapy (PDT)...
  25. Yoo J, Kim C, Chung C, Jeong Y, Kang D. 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy. Int J Nanomedicine. 2012;7:1997-2005 pubmed publisher
    ..For this purpose, 5-aminolevulinic acid (ALA) was incorporated into poly(vinyl alcohol) (PVA) nanofiber, and coated onto metal stents...
  26. Diez B, Ernst G, Teijo M, Batlle A, Hajos S, Fukuda H. Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells. Leuk Res. 2012;36:1179-84 pubmed publisher
    The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant ..
  27. Arita H, Kinoshita M, Kagawa N, Fujimoto Y, Kishima H, Hashimoto N, et al. ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. Cancer. 2012;118:1619-27 pubmed publisher
    The extent of tumor resection is acknowledged as 1 of the prognostic factors for glioma. 5-Aminolevulinic acid (5-ALA)-induced fluorescence guidance and neuronavigation integrated with (11) C-methionine positron emission tomography (PET) ..
  28. Aldave G, Tejada S, Pay E, Marigil M, Bejarano B, Idoate M, et al. Prognostic value of residual fluorescent tissue in glioblastoma patients after gross total resection in 5-aminolevulinic Acid-guided surgery. Neurosurgery. 2013;72:915-20; discussion 920-1 pubmed publisher
  29. Sanai N, Snyder L, Honea N, Coons S, Eschbacher J, Smith K, et al. Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas. J Neurosurg. 2011;115:740-8 pubmed publisher
    ..Although 5-aminolevulinic acid (5-ALA)-induced tumor fluorescence is a strategy that can improve EOR in gliomas, only glioblastomas ..
  30. Shi L, Wang X, Zhao F, Luan H, Tu Q, Huang Z, et al. In vitro evaluation of 5-aminolevulinic acid (ALA) loaded PLGA nanoparticles. Int J Nanomedicine. 2013;8:2669-76 pubmed publisher
    5-Aminolevulinic acid (ALA) is a prodrug for topical photodynamic therapy. The effectiveness of topical ALA can be limited by its bioavailability...
  31. Kim C, Chung C, Lee H, Kim D, Kwak T, Jeong Y, et al. Synergistic effects of 5-aminolevulinic acid based photodynamic therapy and celecoxib via oxidative stress in human cholangiocarcinoma cells. Int J Nanomedicine. 2013;8:2173-86 pubmed publisher
    5-Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has the potential to kill cancer cells via apoptotic or necrotic signals that are dependent on the generation of intracellular reactive oxygen species (ROS)...
  32. Cheng J, Sun X, Guo S, Cao W, Chen H, Jin Y, et al. Effects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages. Int J Nanomedicine. 2013;8:669-76 pubmed publisher
    Inflammatory cells exhibit an elevated level of protoporphyrin IX (PpIX) after the administration of 5-aminolevulinic acid (ALA)...
  33. Apalla Z, Sotiriou E, Panagiotidou D, Lefaki I, Goussi C, Ioannides D. The impact of different fluence rates on pain and clinical outcome in patients with actinic keratoses treated with photodynamic therapy. Photodermatol Photoimmunol Photomed. 2011;27:181-5 pubmed publisher
    ..Each lesion was randomly allocated to 25, 50 or 75 mW/cm2 of topical 5-aminolevulinic acid (5-ALA) PDT, using non-coherent light source...
  34. Colditz M, Jeffree R. Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies. J Clin Neurosci. 2012;19:1471-4 pubmed publisher
    ..The theoretical, biochemical and practical aspects of ALA use are reviewed in Part 2. ..
  35. Al Yousef A, Boccara O, Moyal Barracco M, Zimmermann U, Saiag P. Incomplete efficacy of 5-aminolevulinic acid (5 ALA) photodynamic therapy in the treatment of widespread extramammary Paget's disease. Photodermatol Photoimmunol Photomed. 2012;28:53-5 pubmed publisher
    Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an effective treatment for several conditions such as Bowen's disease, subsets of basal cell carcinomas and actinic keratosis...
  36. Harms F, de Boon W, Balestra G, Bodmer S, Johannes T, Stolker R, et al. Oxygen-dependent delayed fluorescence measured in skin after topical application of 5-aminolevulinic acid. J Biophotonics. 2011;4:731-9 pubmed publisher
    ..fluorescence is readily observed from skin in rat and man after topical application of the PpIX precursor 5-aminolevulinic acid (ALA). Delayed fluorescence lifetimes respond to changes in inspired oxygen fraction and blood supply...
  37. Colditz M, Leyen K, Jeffree R. Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. J Clin Neurosci. 2012;19:1611-6 pubmed publisher
    The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade...
  38. Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, et al. Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells. Mol Cell Biochem. 2011;358:297-307 pubmed publisher
    Accumulation of protoporphyrin IX (PpIX) in cancer cells is a basis of 5-aminolevulinic acid (ALA)-induced photodymanic therapy...
  39. Tykocki T, Michalik R, Bonicki W, Nauman P. Fluorescence-guided resection of primary and recurrent malignant gliomas with 5-aminolevulinic acid. Preliminary results. Neurol Neurochir Pol. 2012;46:47-51 pubmed
    ..The authors present preliminary results of 5-aminolevulinic acid (5-ALA) application during the resection of primary and recurrent MGs...
  40. Della Puppa A, De Pellegrin S, D Avella E, Gioffre G, Rossetto M, Gerardi A, et al. 5-aminolevulinic acid (5-ALA) fluorescence guided surgery of high-grade gliomas in eloquent areas assisted by functional mapping. Our experience and review of the literature. Acta Neurochir (Wien). 2013;155:965-72; discussion 972 pubmed publisher
    Only few data are available on the specific topic of 5-aminolevulinic acid (5-ALA) guided surgery of high-grade gliomas (HGG) located in eloquent areas...
  41. Takahashi K, Hasegawa T, Ishii T, Suzuki A, Nakajima M, Uno K, et al. Antitumor effect of combination of hyperthermotherapy and 5-aminolevulinic acid (ALA). Anticancer Res. 2013;33:2861-6 pubmed
    5-Aminolevulinic acid (ALA) is a precursor of heme...
  42. Ohgari Y, Miyata Y, Miyagi T, Gotoh S, Ohta T, Kataoka T, et al. Roles of porphyrin and iron metabolisms in the ?-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin and photodamage of tumor cells. Photochem Photobiol. 2011;87:1138-45 pubmed publisher
    b>Aminolevulinic acid (ALA)-induced porphyrin accumulation is widely used in the treatment of cancer, as photodynamic therapy...
  43. Ma L, Xiang L, Yu B, Yin R, Chen L, Wu Y, et al. Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. Photodiagnosis Photodyn Ther. 2013;10:583-90 pubmed publisher
    To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen...
  44. Suzuki T, Wada S, Eguchi H, Adachi J, Mishima K, Matsutani M, et al. Cadherin 13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma. J Neurosurg. 2013;119:1331-9 pubmed publisher
    ..Currently, fluorescence-guided resection using orally administered 5-aminolevulinic acid (5-ALA) has proved to be beneficial in improving the prognosis of patients with gliomas...
  45. Oh E, Jin S, Kim J, Park J, Park Y, Kim C. Retained topical delivery of 5-aminolevulinic acid using cationic ultradeformable liposomes for photodynamic therapy. Eur J Pharm Sci. 2011;44:149-57 pubmed publisher
    5-Aminolevulinic acid (5-ALA), inducing photodynamic protoporphyrin (PpIX), is a hydrophilic molecule, resulting in leashing the capacity to cross tissue barriers like stratum corneum (SC) of skin...
  46. Hino H, Murayama Y, Nakanishi M, Inoue K, Nakajima M, Otsuji E. 5-Aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes of different wavelengths in a mouse model of peritoneally disseminated gastric cancer. J Surg Res. 2013;185:119-26 pubmed publisher
    5-Aminolevulinic acid (5-ALA) is a precursor of the strong photosensitizer, protoporphyrin IX, in cancer cells...
  47. Ohmura T, Fukushima T, Shibaguchi H, Yoshizawa S, Inoue T, Kuroki M, et al. Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat. Anticancer Res. 2011;31:2527-33 pubmed
    5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA for deep-seated lesions was evaluated...
  48. Ali B, Huang C, Qi Z, Ali S, Daud M, Geng X, et al. 5-Aminolevulinic acid ameliorates cadmium-induced morphological, biochemical, and ultrastructural changes in seedlings of oilseed rape. Environ Sci Pollut Res Int. 2013;20:7256-67 pubmed publisher
    ..The present study evaluates the ameliorate effects of 5-aminolevulinic acid (ALA, 0, 0.4, 2, and 10 mg/l) on the growth of oilseed rape (B. napus L. cv...
  49. Della Puppa A, Rustemi O, Gioffre G, Troncon I, Lombardi G, Rolma G, et al. Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery. J Neurosurg. 2014;120:840-5 pubmed publisher
    ..The aim of this study was to assess the role of 5-aminolevulinic acid (5-ALA) fluorescence in guiding the resection of bone-invading meningiomas...
  50. Czarnecki O, Hedtke B, Melzer M, Rothbart M, Richter A, Schr ter Y, et al. An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts. Plant Cell. 2011;23:4476-91 pubmed publisher
    5-Aminolevulinic acid (ALA) is the universal precursor for tetrapyrrole biosynthesis and is synthesized in plants in three enzymatic steps: ligation of glutamate (Glu) to tRNA(Glu) by glutamyl-tRNA synthetase, reduction of activated Glu ..
  51. Lv Y, Fang M, Zheng J, Yang B, Li H, Xiuzigao Z, et al. Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma. Cell Physiol Biochem. 2012;30:321-33 pubmed publisher
    ..6 and 0.8 W/cm(2), plus 5-aminolevulinic acid (ALA)...
  52. Mallidi S, Anbil S, LEE S, Manstein D, Elrington S, Kositratna G, et al. Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema. J Biomed Opt. 2014;19:028001 pubmed publisher
    ..and PS re-accumulation post-PDT) to predict the clinical phototoxic response (erythema) resulting from 5-aminolevulinic acid PDT was compared with discrete SOL (DSOL)-based metrics (DSOL counts pre-PDT and change in DSOL counts pre/..
  53. Harris F, Pierpoint L. Photodynamic therapy based on 5-aminolevulinic acid and its use as an antimicrobial agent. Med Res Rev. 2012;32:1292-327 pubmed publisher
    Exogenous 5-aminolevulinic acid (ALA) is taken up directly by bacteria, yeasts, fungi, and some parasites, which then induces the accumulation of protoporphyrin IX (PPIX)...
  54. Valdes P, Kim A, Brantsch M, Niu C, Moses Z, Tosteson T, et al. ?-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro Oncol. 2011;13:846-56 pubmed publisher
    ..In this study we evaluate whether quantitative ex vivo tissue measurements of ?-aminolevulinic acid-induced protoporphyrin IX (PpIX) identify regions of increasing malignancy in low- and high-grade gliomas ..
  55. Chung C, Kim C, Choi K, Yoo J, Kim D, Chung K, et al. Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell. Eur J Pharm Biopharm. 2012;80:453-8 pubmed publisher
    ..PDT was shown to improve the median survival time of advanced-stage patients. Recently, 5-aminolevulinic acid (ALA) has been used as a pro-photosensitizer, which can be transferred to intercellular protoporphyrin IX (..
  56. Naeem M, Warusawitharana H, Liu H, Liu D, Ahmad R, Waraich E, et al. 5-aminolevulinic acid alleviates the salinity-induced changes in Brassica napus as revealed by the ultrastructural study of chloroplast. Plant Physiol Biochem. 2012;57:84-92 pubmed publisher
    5-Aminolevulinic acid (ALA) is an important plant growth regulator which is derived from 5-carbon aliphatic amino acid...