sodium salicylate

Summary

Summary: A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

Top Publications

  1. Thakur P, Nehru B. Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. Neuroscience. 2013;231:420-31 pubmed publisher
    ..The anti-oxidative as well as anti-inflammatory properties of sodium salicylate (SS), suggest its neuroprotective potentials in PD...
  2. Xiao C, Giacca A, Lewis G. The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and ?-cell dysfunction in overweight and obese nondiabetic men. Am J Physiol Endocrinol Metab. 2009;297:E1205-11 pubmed publisher
    ..quot; We studied the effects of sodium salicylate, an anti-inflammatory agent, on lipid-induced alterations in ?-cell function and insulin sensitivity in six ..
  3. Wallhäusser Franke E, Mahlke C, Oliva R, Braun S, Wenz G, Langner G. Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus. Exp Brain Res. 2003;153:649-54 pubmed
    ..In gerbils, we investigated brain activation after systemic application of sodium salicylate or exposure to loud noise, both known to be reliable tinnitus-inductors...
  4. Mohanakumar K, Muralikrishnan D, Thomas B. Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2000;864:281-90 pubmed
    ..The present study suggests that SA acts as a free radical scavenger in the brain and indicates its strength as a valuable neuroprotectant. ..
  5. Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994;265:956-9 pubmed
    ..The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these ..
  6. Yang G, Lobarinas E, Zhang L, Turner J, Stolzberg D, Salvi R, et al. Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats. Hear Res. 2007;226:244-53 pubmed
    ..These preliminary physiology data suggest that salicylate induced tinnitus is associated with sound evoked hyperactivity in auditory cortex and spontaneous hypoactivity. ..
  7. Ruttiger L, Ciuffani J, Zenner H, Knipper M. A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus. Hear Res. 2003;180:39-50 pubmed
    ..Tinnitus was induced by the administration of sodium salicylate (350 mg/kg body weight) given 3 h before testing...
  8. Bair W, Hart N, Einspahr J, Liu G, Dong Z, Alberts D, et al. Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2002;11:1645-52 pubmed
    We conducted an in vivo carcinogenesis experiment to determine the efficacy of topical aspirin and sodium salicylate (NAS) in preventing UVB-induced nonmelanoma skin cancer...
  9. Grilli M, Pizzi M, Memo M, Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science. 1996;274:1383-5 pubmed
    ..with amounts in plasma during chronic anti-inflammatory therapy, acetylsalicylic acid and its metabolite sodium salicylate were found to be protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat ..

More Information

Publications62

  1. Nixon M, Wake D, Livingstone D, Stimson R, Esteves C, Seckl J, et al. Salicylate downregulates 11?-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012;61:790-6 pubmed publisher
    ..We treated diet-induced obese (DIO) 11?-HSD1-deficient mice and C57Bl/6 mice with sodium salicylate for 4 weeks. Glucose tolerance was assessed in vivo...
  2. Winegarden N, Wong K, Sopta M, Westwood J. Sodium salicylate decreases intracellular ATP, induces both heat shock factor binding and chromosomal puffing, but does not induce hsp 70 gene transcription in Drosophila. J Biol Chem. 1996;271:26971-80 pubmed
    b>Sodium salicylate has long been known to be an inducer of the heat shock puffs and presumably heat shock gene transcription in the polytene chromosomes of Drosophila salivary gland cells...
  3. Wu D, Cederbaum A. Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes. Mol Pharmacol. 2001;59:795-805 pubmed
    b>Sodium salicylate and acetylsalicylic acid are drugs used as anti-inflammatory agents. Salicylate prevents nuclear factor-kappa B activation and can cause apoptosis...
  4. Kotschwar J, Coetzee J, Anderson D, Gehring R, Kukanich B, Apley M. Analgesic efficacy of sodium salicylate in an amphotericin B-induced bovine synovitis-arthritis model. J Dairy Sci. 2009;92:3731-43 pubmed publisher
    This study examined the efficacy of sodium salicylate for providing analgesia in an amphotericin B-induced bovine synovitis-arthritis model using 10 male Holstein calves, 4 to 6 mo old and weighing approximately 250 kg...
  5. Paul A, Lobarinas E, Simmons R, Wack D, Luisi J, Spernyak J, et al. Metabolic imaging of rat brain during pharmacologically-induced tinnitus. Neuroimage. 2009;44:312-8 pubmed publisher
  6. Tariq M, Khan H, Al Moutaery K, Al Deeb S. Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats. Pharmacol Biochem Behav. 2002;73:647-54 pubmed
    ..This investigation was undertaken to study the effect of sodium salicylate (SS) on IDPN-induced behavioral abnormalities in rats...
  7. Huang Z, Chen P, Mei L, Fan Q, Xiao B, Wu Z. [Differentially expressed gene profiles of cochlea in rats induced by acute and chronic sodium salicylate injection]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:27-32 pubmed
    To study the mechanism of electrophysiologic changes caused by different type of sodium salicylate injection...
  8. Ebstein W. Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate. J Mol Med (Berl). 2002;80:618; discussion 619 pubmed
  9. Alekshun M, Levy S. Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro. J Bacteriol. 1999;181:4669-72 pubmed
    ..In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered ..
  10. Merinville E, Byrne A, Rawlings A, Muggleton A, Laloeuf A. Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol. 2010;9:174-84 pubmed publisher
    ..To provide evidence that sodium salicylate (SS) obtained from neutralization of 1% SA by sodium hydroxide can deliver significant anti-aging benefits...
  11. Wei L, Ding D, Sun W, Xu Friedman M, Salvi R. Effects of sodium salicylate on spontaneous and evoked spike rate in the dorsal cochlear nucleus. Hear Res. 2010;267:54-60 pubmed publisher
    ..To determine if sodium salicylate, a reliable tinnitus inducer, could evoke hyperactivity in the DCN, we measured the spontaneous and ..
  12. Dinis Oliveira R, de Pinho P, Ferreira A, Silva A, Afonso C, Bastos M, et al. Reactivity of paraquat with sodium salicylate: formation of stable complexes. Toxicology. 2008;249:130-9 pubmed publisher
    b>Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings...
  13. Coetzee J, Gehring R, Bettenhausen A, Lubbers B, Toerber S, Thomson D, et al. Attenuation of acute plasma cortisol response in calves following intravenous sodium salicylate administration prior to castration. J Vet Pharmacol Ther. 2007;30:305-13 pubmed
    ..This study examined the effect of oral aspirin and intravenous (i.v.) sodium salicylate on acute plasma cortisol response following surgical castration...
  14. Dinis Oliveira R, Sousa C, Remião F, Duarte J, Navarro A, Bastos M, et al. Full survival of paraquat-exposed rats after treatment with sodium salicylate. Free Radic Biol Med. 2007;42:1017-28 pubmed
    ..For this purpose, sodium salicylate (NaSAL) may constitute an adequate therapeutic drug, due to its ability to modulate inflammatory signaling ..
  15. Hyppolito M, de Oliveira J, Rossato M. Cisplatin ototoxicity and otoprotection with sodium salicylate. Eur Arch Otorhinolaryngol. 2006;263:798-803 pubmed
    ..Our proposal was to assess the action of sodium salicylate, which has a known antioxidant property, as a possible otoprotector of outer hair cells against the action ..
  16. Saunders M, Sansores Garcia L, Gilroy D, Wu K. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem. 2001;276:18897-904 pubmed
    ..This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-..
  17. Polonio R, Mermel L, Paquette G, Sperry J. Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin. Antimicrob Agents Chemother. 2001;45:3262-6 pubmed
    ..epidermidis (RP62A) by >or=99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 microg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >..
  18. Tran P, Gleason C, Robertson R. Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes. 2002;51:1772-8 pubmed
    ..inhibition of insulin secretion in pancreatic islets; and to examine possible sites of action through which sodium salicylate might affect IL-1beta/PGE(2) interactions...
  19. Baldridge S, Coetzee J, Dritz S, Reinbold J, Gehring R, Havel J, et al. Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves fo. Am J Vet Res. 2011;72:1305-17 pubmed publisher
    To determine the pharmacokinetic parameters of xylazine, ketamine, and butorphanol (XKB) administered IM and sodium salicylate (SAL) administered PO to calves and to compare drug effects on biomarkers of pain and distress following sham ..
  20. Zheng J, Shen W, He D, Long K, Madison L, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000;405:149-55 pubmed publisher
    ..We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell...
  21. Zeender E, Maedler K, Bosco D, Berney T, Donath M, Halban P. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. J Clin Endocrinol Metab. 2004;89:5059-66 pubmed
    ..activation, the thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate, can protect human beta-cells against the toxic effects of IL-1beta and high glucose in vitro...
  22. Dinis Oliveira R, Sousa C, Remião F, Duarte J, Ferreira R, Sanchez Navarro A, et al. Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Free Radic Biol Med. 2007;43:48-61 pubmed
    ..rats, 24, 48, and 96 h after PQ exposure (25 mg/kg ip) as well as the putative healing effects provided by sodium salicylate [(NaSAL), 200 mg/kg ip] when administered 2 h after PQ...
  23. Giardina C, Lis J. Sodium salicylate and yeast heat shock gene transcription. J Biol Chem. 1995;270:10369-72 pubmed
    The anti-inflammatory drug sodium salicylate modulates the activity of specific transcription factors in humans...
  24. He B, Zhao S, Zhang W, Li Y, Han P. Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids. Hepatobiliary Pancreat Dis Int. 2010;9:49-53 pubmed
    ..In insulin-resistant rats, we found that the supplementation of sodium salicylate is associated with a reduction of plasma malondialdehyde (MDA), a marker of oxidative stress...
  25. Pomposiello P, Bennik M, Demple B. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. J Bacteriol. 2001;183:3890-902 pubmed
    ..to the superoxide-generating agent paraquat (PQ), an inducer of the soxRS system, and to the weak acid salt sodium salicylate (NaSal), an inducer of the marRA system...
  26. Ferrero C, Massuelle D, Jeannerat D, Doelker E. Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. I. Pulse-field-gradient spin-echo NMR study of sodium salicylate diffusivity in swollen hydrogels with respect to polymer matrix physical. J Control Release. 2008;128:71-9 pubmed publisher
    ..nuclear magnetic resonance (PFG-SE NMR) was used to investigate the self-diffusion of the model solute sodium salicylate and, incidentally, that of water, in hydrogels made of hydroxypropyl methylcellulose (HPMC), ..
  27. Wang H, Luo B, Huang Y, Zhou K, Chen L. Sodium salicylate suppresses serotonin-induced enhancement of GABAergic spontaneous inhibitory postsynaptic currents in rat inferior colliculus in vitro. Hear Res. 2008;236:42-51 pubmed publisher
    Available evidence suggests that sodium salicylate (SS) may produce tinnitus through altering the balance between inhibition and excitation in the central auditory system...
  28. Kwon K, Chae H. Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes. Arch Pharm Res. 2003;26:545-53 pubmed
    ..of cyclooxygenase-2 (COX-2) is a characteristic response to inflammation, which can be inhibited with sodium salicylate. IL-1beta and TNF-alpha can induce extracellular signal-regulated kinase (ERK), IKK, IkappaB degradation and ..
  29. Dong Z, Huang C, Brown R, Ma W. Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. J Biol Chem. 1997;272:9962-70 pubmed
    ..The inhibition effects on the activation of AP-1 activity by aspirin and aspirin-like salicylates may further explain the anti-carcinogenesis mechanism of action of these drugs. ..
  30. Moon C, Ahn M, Jee Y, Heo S, Kim S, Kim H, et al. Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases. Neurosci Lett. 2004;356:123-6 pubmed
    We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune ..
  31. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li Z, Karin M, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001;293:1673-7 pubmed
    ..These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization. ..
  32. Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells. J Pharm Pharmacol. 2002;54:1675-9 pubmed
    ..In this study, we examined whether aspirin and sodium salicylate inhibit cell growth and induce apoptosis in rheumatoid synovial cells...
  33. Lemay S, Lebedeva T, Singh A. Inhibition of cytokine gene expression by sodium salicylate in a macrophage cell line through an NF-kappaB-independent mechanism. Clin Diagn Lab Immunol. 1999;6:567-72 pubmed
    ..We have therefore studied the effects of sodium salicylate on lipopolysaccharide (LPS)-induced kappaB-binding activity and on cytokine and chemokine gene expression in ..
  34. Bau J, Kurz E. Sodium salicylate is a novel catalytic inhibitor of human DNA topoisomerase II alpha. Biochem Pharmacol. 2011;81:345-54 pubmed publisher
    ..this effect was attenuated by pretreatment of cells with the hydroxyl radical scavengers sodium benzoate, sodium salicylate and, to a lesser extent, N-acetyl cysteine, but not Trolox™...
  35. Su Y, Luo B, Wang H, Chen L. Differential effects of sodium salicylate on current-evoked firing of pyramidal neurons and fast-spiking interneurons in slices of rat auditory cortex. Hear Res. 2009;253:60-6 pubmed publisher
    b>Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system...
  36. Derouet M, Thomas L, Moulding D, Akgul C, Cross A, Moots R, et al. Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1. J Immunol. 2006;176:957-65 pubmed
    ..In this report, we show that sodium salicylate (at 10 mM) greatly enhances the rate at which neutrophils undergo apoptosis and, in parallel, greatly ..
  37. Wang H, Luo B, Zhou K, Xu T, Chen L. Sodium salicylate reduces inhibitory postsynaptic currents in neurons of rat auditory cortex. Hear Res. 2006;215:77-83 pubmed
    b>Sodium salicylate (SS) is a medicine for anti-inflammation and for chronic pain relief with a side effect of tinnitus...
  38. Baert K, De Backer P. Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. J Vet Pharmacol Ther. 2002;25:449-53 pubmed
    Three nonsteroidal anti-inflammatory drugs (NSAIDs) [sodium salicylate, flunixin (FLU) and meloxicam (MEL)] were administered intravenously to broiler chickens...
  39. Yin S, Tang A, Xing X, Tan S, Xie L. [Effects of sodium salicylate on the expressions of gamma-aminobutyricacid and glutamate and auditory response properties of the inferior colliculus neurons]. Sheng Li Xue Bao. 2006;58:449-55 pubmed
    The effects of sodium salicylate (NaSA) on the expressions of gamma-aminobutyricacid (GABA) and glutamate (Glu), and auditory response properties of the inferior colliculus neurons in mice were studied...
  40. Liu Y, Li X. Effects of salicylate on voltage-gated sodium channels in rat inferior colliculus neurons. Hear Res. 2004;193:68-74 pubmed
    To investigate the effects of the tinnitus inducer, sodium salicylate, on voltage-gated sodium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method...
  41. Sakitani K, Kitade H, Inoue K, Kamiyama Y, Nishizawa M, Okumura T, et al. The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1beta at a translational step, but not at a transcriptional step, in hepatocytes. Hepatology. 1997;25:416-20 pubmed
    ..b>Sodium salicylate markedly inhibited the NO formation induced by IL-1beta, but did not affect NF-kappaB activation and iNOS ..
  42. Takahashi K, Komai M, Kinoshita N, Nakamura E, Hou X, Takatani Nakase T, et al. Application of hydrotropy to transdermal formulations: hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU. J Pharm Pharmacol. 2011;63:1008-14 pubmed publisher
    ..The enhancement effect was also compared with the hydrotropic formulation and the other formulations using ethanol, propylene glycol or mixed micelles...
  43. Sairam K, Saravanan K, Banerjee R, Mohanakumar K. Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res. 2003;966:245-52 pubmed
    We evaluated the hydroxyl radical (*OH) scavenging action of nonsteroidal anti-inflammatory drugs (NSAIDs), sodium salicylate (SA), diclofenac and celecoxib in Fenton's reaction and their neuroprotective effects in 1-methyl-4-..
  44. Amann R, Peskar B. Anti-inflammatory effects of aspirin and sodium salicylate. Eur J Pharmacol. 2002;447:1-9 pubmed
    ..providing an overview about the often conflicting results concerning the mechanisms of action of aspirin and sodium salicylate. At present, there is no common agreement about the extent to which salicylate contributes to aspirin's anti-..
  45. Xu H, Gong N, Chen L, Xu T. Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons. Neuroreport. 2005;16:813-6 pubmed
    b>Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief...
  46. Park E, Wong V, Guan X, Oprescu A, Giacca A. Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo. J Endocrinol. 2007;195:323-31 pubmed
    ..In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta , prevents hepatic insulin resistance caused by short-term elevation of FFA...
  47. Lee E, Park H, Kang H. Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. Int J Oncol. 2003;23:503-8 pubmed
    b>Sodium salicylate is known to induce apoptosis in a variety of cancer cells. However, the molecular mechanism for salicylate-induced apoptosis is yet unclear...
  48. Seo M, Oh S, Park M, Kim S, Kim M, Han S, et al. Implication of reactive oxygen species, ERK1/2, and p38MAPK in sodium salicylate-induced heat shock protein 72 expression in C6 glioma cells. Int J Mol Med. 2005;16:841-9 pubmed
    b>Sodium salicylate, one of anti-inflammatory agents, is known to partially induce the heat shock response: it stimulates the DNA-binding of heat shock factor 1 (HSF1) without inducing heat shock gene expression...
  49. Mitchell J, Saunders M, Barnes P, Newton R, Belvisi M. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997;51:907-12 pubmed
    ..b>Sodium salicylate inhibited prostaglandin E2 release when added together with interleukin 1beta for 24 hr with an IC50 value ..
  50. Foulon O, Jaussely C, Repetto M, Urtizberea M, Blacker A. Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate. J Appl Toxicol. 2000;20:205-9 pubmed
    ..Initially, 30 pregnant female rats were randomly distributed into two groups receiving 0 or 300 mg kg(-1) sodium salicylate on day 9 of pregnancy...
  51. Di Renzo F, Cappelletti G, Broccia M, Giavini E, Menegola E. The inhibition of embryonic histone deacetylases as the possible mechanism accounting for axial skeletal malformations induced by sodium salicylate. Toxicol Sci. 2008;104:397-404 pubmed publisher
    ..be the mechanism responsible for axial skeletal defects described after the exposure of pregnant rodents to sodium salicylate (SAL)...
  52. Osnes L, Foss K, Joø G, Okkenhaug C, Westvik A, Ovstebø R, et al. Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-alpha) in human monocytes. Thromb Haemost. 1996;76:970-6 pubmed
    We have investigated the effects of acetylsalicylic acid and sodium salicylate on the LPS-induced synthesis of the pro-coagulant protein tissue factor (TF) and the pro-inflammatory protein tumor necrosis factor-alpha (TNF-alpha), as well ..
  53. Chung Y, Bae Y, Lee S. Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis. Free Radic Biol Med. 2003;34:434-42 pubmed
    ..We examined the effects of sodium salicylate (NaSal) on reactive oxygen species (ROS) production and the association of these effects with apoptotic ..