Summary: The imide of phthalic acids.

Top Publications

  1. Fellner M, Horton L, Cocke A, Stephens N, Ford E, Van Volkenburgh E. Light interacts with auxin during leaf elongation and leaf angle development in young corn seedlings. Planta. 2003;216:366-76 pubmed
    ..The more erect leaves in 3394 may contribute to the tolerance of the modern corn hybrid to dense planting. ..
  2. Hennessy E, Buchwald S. Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination. J Org Chem. 2005;70:7371-5 pubmed
    ..Thus, a variety of DAPH analogues can be quickly accessed in a modular fashion. In addition, the route described herein should also be amenable to the incorporation of other classes of nucleophiles into the molecular framework. ..
  3. Falcão E, de Melo S, Srivastava R, Catanho M, Do Nascimento S. Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3- and 4-(N-phthalimidophenyl)} pyrimidines. Eur J Med Chem. 2006;41:276-82 pubmed
    ..7a-c have been found to be twice more active than aspirin. Cytotoxical evaluations of compounds 7a-e using neoplastic cells (NCI-H(292) and Hep-2) presented 41% of growth inhibition of neoplastic cells NCI-H(292). ..
  4. Siedlecki P, Garcia Boy R, Musch T, Brueckner B, Suhai S, Lyko F, et al. Discovery of two novel, small-molecule inhibitors of DNA methylation. J Med Chem. 2006;49:678-83 pubmed
    ..The newly discovered inhibitors validate our screening procedure and also provide a useful basis for further rational drug development. ..
  5. Wang H, Duennwald M, Roberts B, Rozeboom L, Zhang Y, Steele A, et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc Natl Acad Sci U S A. 2008;105:7159-64 pubmed publisher
    ..Our studies provide mechanistic insights and reinvigorate hopes for small-molecule therapies that specifically disrupt intermolecular amyloid contacts. ..
  6. Wang F, Liu H, Irwin M, Xia Z, Huang Z, Ouyang J, et al. Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis. Can J Physiol Pharmacol. 2009;87:221-9 pubmed publisher
    ..CGP53353, but not rottlerin, abolished or attenuated all these changes. We conclude that PKCbeta(2) plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis. ..
  7. Verschueren W, Dierynck I, Amssoms K, Hu L, Boonants P, Pille G, et al. Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase. J Med Chem. 2005;48:1930-40 pubmed
  8. Sieberer T, Leyser O. Plant science. Auxin transport, but in which direction?. Science. 2006;312:858-60 pubmed
  9. Meng X, Han D, Zhang S, Guo W, Cui J, Li Z. Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2,3-dideoxy- and 2,3-unsaturated glycosides. Carbohydr Res. 2007;342:1169-74 pubmed
    ..Following deacetylation, the anti-inflammatory activities of these compounds were tested on mice and three were found to possess potent activity compared to hydrocortisone sodium succinate (HSS). ..

More Information

Publications102 found, 100 shown here

  1. Deng B, Xie S, Wang J, Xia Z, Nie R. Inhibition of protein kinase C ?(2) prevents tumor necrosis factor-?-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. J Vasc Res. 2012;49:144-59 pubmed publisher
    ..Upregulation of expression of NADPH subunits is important in this process, which leads to a new target in antioxidative therapy for vascular disease prevention. ..
  2. Blanck S, Geisselbrecht Y, Kräling K, Middel S, Mietke T, Harms K, et al. Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition. Dalton Trans. 2012;41:9337-48 pubmed publisher
    ..The biological activity of this new class of metalated phthalimides was evaluated by profiling two representative members against a large panel of human protein kinases...
  3. Lima L, Castro P, Machado A, Fraga C, Lugnier C, de Moraes V, et al. Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues. Bioorg Med Chem. 2002;10:3067-73 pubmed
    ..5mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. ..
  4. Sena V, Srivastava R, Silva R, Lima V. Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V. Farmaco. 2003;58:1283-8 pubmed
    A series of N-aryl- or N-(1,2,4-triazol-yl)-phthalimides (4a-4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a-2i)...
  5. Zhang S, Li Z, Cai M. Synthesis of N-sugar-substituted phthalimides and their derivatives from sugar azides and phthalic anhydride. Carbohydr Res. 2004;339:1419-20 pubmed
    N-Sugar-substituted phthalimides and tetrachlorophthalimide derivatives can be prepared in good yields under essentially neutral conditions...
  6. Casimiro I, Marchant A, Bhalerao R, Beeckman T, Dhooge S, Swarup R, et al. Auxin transport promotes Arabidopsis lateral root initiation. Plant Cell. 2001;13:843-52 pubmed
  7. Ljung K, Bhalerao R, Sandberg G. Sites and homeostatic control of auxin biosynthesis in Arabidopsis during vegetative growth. Plant J. 2001;28:465-74 pubmed
    ..This indicates that leaves are not only important sources for IAA synthesis, but that normal leaf expansion depends on rigorous control of IAA homeostasis. ..
  8. Morris D. Transmembrane auxin carrier systems--dynamic regulators of polar auxin transport. Plant Growth Regul. 2000;32:161-72 pubmed
    ..The way is now clear for the development of specific molecular probes with which to investigate the intracellular transport and targeting of auxin carrier proteins. ..
  9. Novak I, Kovac B. Photochemistry via photoelectron spectroscopy: N-substituted phthalimides. J Phys Chem A. 2006;110:7772-6 pubmed
    The electronic structures of several N-substituted phthalimides have been investigated by UV photoelectron spectroscopy and outer valence Greens function calculations...
  10. Holzgrabe U, De Amici M, Mohr K. Allosteric modulators and selective agonists of muscarinic receptors. J Mol Neurosci. 2006;30:165-8 pubmed
    ..The cooperativity is strongly dependent on the pair of allosteric/orthosteric ligands and on the receptor subtype. ..
  11. Roberts B, Duennwald M, Wang H, Chung C, Lopreiato N, Sweeny E, et al. A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nat Chem Biol. 2009;5:936-46 pubmed publisher
    ..Thus, synergistic small-molecule combinations that directly eradicate complete strain repertoires likely hold considerable therapeutic potential. ..
  12. Takaku T, Nagahori H, Sogame Y. Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals. Toxicol Appl Pharmacol. 2014;277:242-9 pubmed publisher
    ..For the safety assessment of flumioxazin, these results would be useful for further in vitro toxicology experiments. ..
  13. Huang H, Liu X, Deng J, Qiu M, Zheng Z. Rhodium-catalyzed enantioselective hydrogenation of beta-phthalimide acrylates to synthesis of beta2-amino acids. Org Lett. 2006;8:3359-62 pubmed
    ..Structure: see text] The enantioselective hydrogenation of beta-phthalimide acrylates provides the corresponding chiral beta2-amino acids in excellent enantiomeric excess catalyzed by Rh-monophosphorus...
  14. Miknyoczki S, Chang H, Grobelny J, Pritchard S, Worrell C, McGann N, et al. The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity. Mol Cancer Ther. 2007;6:2290-302 pubmed
    ..These data indicate that CEP-8983 and its prodrug are effective chemosensitizing agents when administered in combination with select chemotherapeutic agents against chemoresistant tumors. ..
  15. García Barrantes P, Cho H, Blobaum A, Niswender C, Conn P, Lindsley C. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs. Bioorg Med Chem Lett. 2016;26:1869-72 pubmed publisher
  16. Rishton G. Aggregator compounds confound amyloid fibrillization assay. Nat Chem Biol. 2008;4:159-60 pubmed publisher
  17. de Farias Silva N, Lameira J, Alves C. Computational analysis of aspartic protease plasmepsin II complexed with EH58 inhibitor: a QM/MM MD study. J Mol Model. 2011;17:2631-8 pubmed publisher
    ..The results indicate that the protonation of Asp214 favors a stable active site structure, which is consistent with our electrostatic binding free energy calculation and with previous published works. ..
  18. Takanashi K, Sugiyama A, Yazaki K. Involvement of auxin distribution in root nodule development of Lotus japonicus. Planta. 2011;234:73-81 pubmed publisher
    ..The inhibition of lenticel formation was correlated with the inhibition of nodule vascular bundle development. These results indicate that auxin is required for the normal development of determinate nodules in a multidirectional manner. ..
  19. Podbielska M, Szpyrka E, Piechowicz B, Zwolak A, Sadło S. Behavior of fluopyram and tebuconazole and some selected pesticides in ripe apples and consumer exposure assessment in the applied crop protection framework. Environ Monit Assess. 2017;189:350 pubmed publisher
    ..3% for the Gala variety and 9.3% for the Lobo variety. Likewise, the long-term daily intake of the detected substances by a Polish adult consumer was low, ranging from 0.02% ADI for pirimicarb to 0.72% ADI for captan. ..
  20. Mendyk A, Sałat K, Librowski T, Czarneck R, Malawska B. Influence of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice. Pol J Pharmacol. 2001;53:689-93 pubmed
  21. Lund I, Andersen H, Iversen L, Olsen O, Møller K, Pedersen A, et al. Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta. J Biol Chem. 2004;279:24226-35 pubmed
    ..Therefore, we anticipate that this strategy, here applied to PTPbeta, in principle can be used in the design and development of selective inhibitors of many, if not most PTPs. ..
  22. Penter L, Maier B, Frede U, Hackner B, Carell T, Hagemeier C, et al. A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma. Target Oncol. 2015;10:523-33 pubmed publisher
    ..These results complement existing studies and underline the reliability and versatility of our single well-based protocol. ..
  23. Di Landro A, Greco V, Valsecchi R. 'Lucky Luke' contact dermatitis from diapers with negative patch tests. Contact Dermatitis. 2002;46:48-9 pubmed
  24. Ferrell J, Vencill W. Flumioxazin soil persistence and mineralization in laboratory experiments. J Agric Food Chem. 2003;51:4719-21 pubmed
    ..2% after 64 days) than in the Greenville soil (2.0% after 64 days). From these data, it was concluded that microbes were the most influential factor concerning the degradation of flumioxazin. ..
  25. Smith A, Nourizadeh S, Peer W, Xu J, Bandyopadhyay A, Murphy A, et al. Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids. Plant J. 2003;36:433-42 pubmed
    ..Our results indicate that AtGSTF2 is involved not only in stress responses but also in development under normal growth conditions. ..
  26. Bigot A, Fontaine F, Clement C, Vaillant Gaveau N. Effect of the herbicide flumioxazin on photosynthetic performance of grapevine (Vitis vinifera L.). Chemosphere. 2007;67:1243-51 pubmed
    ..Stomatal closure, PSII photochemistry, change in energy metabolism and RuBP activity were affected by fmx treatment. ..
  27. Kawamura S, Yoshioka T, Mito N, Kishimoto N, Nakaoka M, Fantel A. Mechanism of Developmental Effects in Rats Caused by an N-Phenylimide Herbicide: Transient Fetal Anemia and Sequelae during Mid-to-Late Gestation. Birth Defects Res B Dev Reprod Toxicol. 2016;107:45-59 pubmed publisher
    ..Compensatory enlargement of the fetal heart results in failure of interventricular foramen closure and VSD. Reduced serum protein leads to delayed ossification and wavy ribs. ..
  28. Takahashi T, Mizuno T, Ido T, Iwata R, Watanabe K. Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds. Appl Radiat Isot. 2003;58:557-66 pubmed
    ..Direct tosylation with silver tosylate was effected in 65-85% yield for most commercial bromo-compounds, and with potassium phthalimide, the bromo-compounds in cold run were converted easily into phthalimide-compounds in 84-90% yield. ..
  29. Motoshima K, Ishikawa M, Hashimoto Y, Sugita K. Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity. Bioorg Med Chem. 2011;19:3156-72 pubmed publisher
    ..The results of structure-activity relationship analysis and docking studies led us to the potent PPAR agonists 13c-e. The absolute configuration of 13c-e affects the PPAR subtype selectivity. ..
  30. Okamoto H, Konishi H, Satake K. Fluorescence response of 3-trifluoroacetylaminophthalimide to a Li(+)-I(-) ion pair induced by 254 nm photolysis in acetonitrile. Chem Commun (Camb). 2012;48:2346-8 pubmed publisher
    ..A 3-trifluoroacetylaminophthalimide selectively distinguished LiI from other alkaline-metal iodides and lithium halides by a marked fluorescence colour change, from orange-yellow to sky-blue, subsequent to 254 nm photolysis. ..
  31. Ohashi Ito K, Matsukawa M, Fukuda H. An atypical bHLH transcription factor regulates early xylem development downstream of auxin. Plant Cell Physiol. 2013;54:398-405 pubmed publisher
    ..Moreover, N-1-naphthylphthalamic acid caused ectopic LHL3 expression in accordance with induced auxin maximum. These results suggest that LHL3 plays a positive role in xylem differentiation downstream of auxin. ..
  32. Tegg R, Shabala S, Cuin T, Davies N, Wilson C. Enhanced resistance to the cellulose biosynthetic inhibitors, thaxtomin A and isoxaben in Arabidopsis thaliana mutants, also provides specific co-resistance to the auxin transport inhibitor, 1-NPA. BMC Plant Biol. 2013;13:76 pubmed publisher
    ..We also show that NPA inhibitory response in roots occurs in the mature root zone but not the elongation zone. Responses of mutants to CBIs indicate a similar, but not identical mode of action of TA and IXB, in contrast to DCB. ..
  33. Akgul O, Sultan Kilic F, Erol K, Pabuccuoglu V. Synthesis and anticonvulsant activity of some N-phenyl-2-phtalimidoethanesulfonamide derivatives. Arch Pharm (Weinheim). 2007;340:656-60 pubmed
    ..However, introducing certain substituents, such as nitro, methyl, and chloro, into the N-phenyl ring lead to more active compounds in comparison to the unsubstituted derivatives. ..
  34. Bradley S, Watson J, Challiss R. Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor. Mol Pharmacol. 2009;76:1302-13 pubmed publisher
    ..g., transcriptional regulation) that is unachievable through orthosteric ligand interactions. ..
  35. Hernández I, Munné Bosch S. Naringenin inhibits seed germination and seedling root growth through a salicylic acid-independent mechanism in Arabidopsis thaliana. Plant Physiol Biochem. 2012;61:24-8 pubmed publisher
  36. Si W, Zhang T, Zhang L, Mei X, Dong M, Zhang K, et al. Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2016;26:2380-2 pubmed publisher
    ..The protein-ligand docking study demonstrated that the target compounds have special binding modes and these results are in agreement with the kinetic study. ..
  37. Lei S, Su W, Liu H, Xu J, Xia Z, Yang Q, et al. Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-?: the role of PKC-?2 and NADPH oxidase. Oxid Med Cell Longev. 2013;2013:678484 pubmed publisher
    ..It is concluded that nitroglycerine comprises the protective effects of propofol against TNF-? stimulation in endothelial cells, primarily through PKC-?2 dependent NADPH oxidase activation. ..
  38. Okunrobo L, Usifoh C, Scriba G. Synthesis and pharmacological evaluation of 2-hydroxymethylbenzamides as anti-inflammatory and analgesic agents. Acta Pol Pharm. 2006;63:25-31 pubmed
  39. Sim Y, Ariffin A, Khan M. Kinetic evidence for the formation of monocationic N,N'-disubstituted phthalamide in tertiary amine-catalyzed hydrolysis of N-substituted phthalimides. J Org Chem. 2007;72:8452-8 pubmed
  40. Chen K, Mackie J, Wojtalewicz D, Kennedy E, Dlugogorski B. Toxic pollutants emitted from thermal decomposition of phthalimide compounds. J Hazard Mater. 2011;187:407-12 pubmed publisher
    ..The oxidation of THPI produced 2-cyclohexen-1-one, a toxic unsaturated ketone. The results of the present study provide the data for quantitative risk assessments of emissions of toxicants in combustion processes involving PI and THPI. ..
  41. Xie L, Zheng H, Ye W, Qiu S, Lin Z, Guo L, et al. Novel colorimetric molecular switch based on copper(I)-catalyzed azide-alkyne cycloaddition reaction and its application for flumioxazin detection. Analyst. 2013;138:688-92 pubmed publisher
    ..14-14 nM, and the limit of detection was 0.056 nM (S/N = 3), which can meet the requirement of the maximum residue limits (MRLs) of United States of America (56 nM). ..
  42. Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall N, et al. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol Pharmacol. 2003;64:180-90 pubmed
  43. Miyamoto K, Hoshino T, Yamashita M, Ueda J. Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport. Physiol Plant. 2005;123:467-74 pubmed
  44. Barreda M, Lopez F, Villarroya M, Beltran J, García Baudín J, Hernandez F. Residue determination of captan and folpet in vegetable samples by gas chromatography/negative chemical ionization-mass spectrometry. J AOAC Int. 2006;89:1080-7 pubmed
    ..The limit of detection for both compounds were estimated to be 0.01 mg/kg. The developed method has been applied to treated and untreated samples collected from residue trials. ..
  45. Tang S, Peng P, Pi S, Liang Y, Wang N, Li J. Sequential intermolecular aminopalladation/ortho-arene C-H activation reactions of N-phenylpropiolamides with phthalimide. Org Lett. 2008;10:1179-82 pubmed publisher
    ..intermolecular aminopalladation/C-H activation method for selectively synthesizing (E)-(2-oxindolin-3-ylidene)phthalimides has been developed...
  46. Wu W, McKown L, Kuo G. Metabolism of the new alpha-1A-adrenergic receptor antagonist, phthalimide-phenylpiperazine analog (RWJ-69442), in rat, dog and human hepatic S9 fractions, and in rats. Eur J Drug Metab Pharmacokinet. 2005;30:113-20 pubmed
    ..RWJ-69442 is extensively metabolized in vitro in the rat and human (except dog), and in vivo in the rat. ..
  47. Dobek K. Temperature influence on the energy of nonspecific and specific interactions taking place between 4-aminophthalimide (4-AP) and homogeneous solvents. Photochem Photobiol Sci. 2008;7:361-70 pubmed publisher
    ..Temperature has been found to have different impact on the changes, upon excitation of the probe, in the mean values of the energies of different hydrogen bonds formed by 4-AP with solvents molecules. ..
  48. Geoffroy L, Frankart C, Eullaffroy P. Comparison of different physiological parameter responses in Lemna minor and Scenedesmus obliquus exposed to herbicide flumioxazin. Environ Pollut. 2004;131:233-41 pubmed
    ..The results demonstrated that the observed toxicity is related not only to interspecific variations but also to the selected parameter...
  49. Santner A, Watson J. The WAG1 and WAG2 protein kinases negatively regulate root waving in Arabidopsis. Plant J. 2006;45:752-64 pubmed
    ..Promoter fusions to the gusA reporter gene demonstrate that the WAG promoters are most active in root tips, consistent with the observed phenotypes in the wag mutants. ..
  50. Bar Nun N, Sachs T, Mayer A. A role for IAA in the infection of Arabidopsis thaliana by Orobanche aegyptiaca. Ann Bot. 2008;101:261-5 pubmed
    ..Disruption of auxin action or auxin flow at the contact site could be a novel basis for controlling infection by Orobanche. ..
  51. Brozic P, Cesar J, Kovac A, Davies M, Johnson A, Fishwick C, et al. Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1. Chem Biol Interact. 2009;178:158-64 pubmed publisher
  52. Wang Y, Lin W, Chen X, Xue H. The role of Arabidopsis 5PTase13 in root gravitropism through modulation of vesicle trafficking. Cell Res. 2009;19:1191-204 pubmed publisher
    ..These results suggest that 5PTase13 may modulate auxin transport by regulating vesicle trafficking and thereby play a role in root gravitropism. ..
  53. Niu Y, Jin C, Jin G, Zhou Q, Lin X, Tang C, et al. Auxin modulates the enhanced development of root hairs in Arabidopsis thaliana (L.) Heynh. under elevated CO(2). Plant Cell Environ. 2011;34:1304-17 pubmed publisher
    ..Our study suggests that elevated CO(2) enhanced the development of root hairs in Arabidopsis via the well-characterized auxin signalling and transport that modulate the initiation of root hairs and the expression of its specific genes. ..
  54. Das S, Sarkar M. Rotational dynamics of coumarin-153 and 4-aminophthalimide in 1-ethyl-3-methylimidazolium alkylsulfate ionic liquids: effect of alkyl chain length on the rotational dynamics. J Phys Chem B. 2012;116:194-202 pubmed publisher
  55. Pattison R, Catalá C. Evaluating auxin distribution in tomato (Solanum lycopersicum) through an analysis of the PIN and AUX/LAX gene families. Plant J. 2012;70:585-98 pubmed publisher
  56. Valensin D, Cau Y, Calandro P, Vignaroli G, Dello Iacono L, Chiariello M, et al. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions. Bioorg Med Chem Lett. 2016;26:894-898 pubmed publisher
    ..Our work provides molecular insights to the bioactive form of the 14-3-3 PPI inhibitor and facilitates further development as candidate therapeutic agent. ..
  57. Kim T, Wolford M, Topp M. Ultrashort-lived excited states of aminophthalimides in fluid solution. Photochem Photobiol Sci. 2003;2:576-84 pubmed
  58. Chhun T, Uno Y, Taketa S, Azuma T, Ichii M, Okamoto T, et al. Saturated humidity accelerates lateral root development in rice (Oryza sativa L.) seedlings by increasing phloem-based auxin transport. J Exp Bot. 2007;58:1695-704 pubmed
    ..It is proposed that high humidity conditions accelerate the phloem-based transport of IAA from the leaf to the root, resulting in an increase in the number of lateral roots. ..
  59. Coseri S, Nistor G, Fras L, Strnad S, Harabagiu V, Simionescu B. Mild and selective oxidation of cellulose fibers in the presence of N-hydroxyphthalimide. Biomacromolecules. 2009;10:2294-9 pubmed publisher
    ..Notably, water retention values of the oxidized fibers increased by 30% in comparison with the original nonoxidized sample, as a result of the introduction of hydrophilic carboxylate groups. ..
  60. Smrdel P, Grabnar I, Locatelli I, Cerne M, Andrensek S, Kovacic N, et al. Physicochemical and preclinical pharmacokinetic and toxicological evaluation of LK-423--a new phthalimido-desmuramyl-dipeptide derivative with immunomodulating activity. Drug Dev Ind Pharm. 2009;35:1293-304 pubmed publisher
    ..Acute and a subchronic toxicity results indicate that LK-423 is a safe and nontoxic drug under the applied experimental conditions. ..
  61. Zhang Q, Li J, Zhang W, Yan S, Wang R, Zhao J, et al. The putative auxin efflux carrier OsPIN3t is involved in the drought stress response and drought tolerance. Plant J. 2012;72:805-16 pubmed publisher
  62. Assis S, da Silva M, de Oliveira R, Lima V. Synthesis and anti-inflammatory activity of new alkyl-substituted phthalimide 1H-1,2,3-triazole derivatives. ScientificWorldJournal. 2012;2012:925925 pubmed publisher
    ..activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes...
  63. Min B, Kim D, Park H, Jun C. Pd/C-Catalyzed Carbonylative Esterification of Aryl Halides with Alcohols by Using Oxiranes as CO Sources. Chemistry. 2016;22:6234-8 pubmed publisher
    ..Intramolecular versions of this process serve as methods for the synthesis of lactones and phthalimides.
  64. Plieth C, Trewavas A. Reorientation of seedlings in the earth's gravitational field induces cytosolic calcium transients. Plant Physiol. 2002;129:786-96 pubmed
    ..It is concluded that [Ca(2+)](c) is part of the gravity transduction mechanism in young Arabidopsis seedlings. ..
  65. dos Santos H, Purgatto E, Mercier H, Buckeridge M. The control of storage xyloglucan mobilization in cotyledons of Hymenaea courbaril. Plant Physiol. 2004;135:287-99 pubmed
    ..This is likely to increase the efficiency of carbon reserves utilization by the growing seedling in the understorey light conditions of the rain forest. ..
  66. Warzecha K, Gorner H, Griesbeck A. Photoinduced decarboxylative benzylation of phthalimide triplets with phenyl acetates: a mechanistic study. J Phys Chem A. 2006;110:3356-63 pubmed
    The photodecarboxylative benzylation of N-alkyl, N-arylalkyl, and N-aryl phthalimides with arylacetic acids in aqueous solution proceeds via electron transfer from the arylalkanoate to the excited triplet state of the phthalimide, either ..
  67. Feng B, Toyama B, Wille H, Colby D, Collins S, May B, et al. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008;4:197-9 pubmed publisher
    ..They also blocked infection of yeast cells with Sup35 prions, which suggests that colloidal inhibition may be relevant in more biological milieus. ..
  68. Shi C, Park H, Lee J, Ryu S, Ryu C. Inhibition of primary roots and stimulation of lateral root development in Arabidopsis thaliana by the rhizobacterium Serratia marcescens 90-166 is through both auxin-dependent and -independent signaling pathways. Mol Cells. 2010;29:251-8 pubmed publisher
    ..Collectively, our results suggest that strain 90-166 can contribute to plant root development via multiple signaling pathways. ..
  69. Horvat M, Uzelac L, Marjanović M, Cindro N, Franković O, Mlinarić Majerski K, et al. Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro. Chem Biol Drug Des. 2012;79:497-506 pubmed publisher
    A series of (1-adamantyl)phthalimides, 1-4, and (2-adamantyl)phthalimides, 5-8, characterized by different chain length between the adamantyl and the phthalimide moiety were synthesized, as well as 1- and 2-adamantylphthalimides ..
  70. Dobek K, Karolczak J, Komar D. Temperature influence on 4-aminophthalimide emission in 1-chloroalkanes plus water mixtures. J Phys Chem A. 2012;116:6655-63 pubmed publisher
  71. Petrasek J, Elckner M, Morris D, Zazimalova E. Auxin efflux carrier activity and auxin accumulation regulate cell division and polarity in tobacco cells. Planta. 2002;216:302-8 pubmed
  72. Sun H, Basu S, Brady S, Luciano R, Muday G. Interactions between auxin transport and the actin cytoskeleton in developmental polarity of Fucus distichus embryos in response to light and gravity. Plant Physiol. 2004;135:266-78 pubmed
    ..Together, these results indicate a role for auxin in the orientation of developmental polarity and suggest interactions between the actin cytoskeleton and auxin transport in F. distichus embryos...
  73. Huang H, Chen Y, Wu Y. Experimental studies of the effects of ZnPcS2P2-based-photodynamic therapy on bone marrow purging. Chin Med J (Engl). 2005;118:105-10 pubmed
    ..Under an identical condition, the inhibitory rates of CFU-Mix, CFU-GM, CFU-E were 18.0%, 18.6%, and 17.8% respectively. ZnPc-PDT appears to be a promising approach for bone marrow purging. ..
  74. Genet J, Jaworska G, Deparis F. Effect of dose rate and mixtures of fungicides on selection for QoI resistance in populations of Plasmopara viticola. Pest Manag Sci. 2006;62:188-94 pubmed
    ..These results suggest that the choice of the fungicide partner and its dosage in the mixture can significantly affect the success of QoI resistance management strategies under practical conditions...
  75. Dessalew N. Investigation of the structural requirement for inhibiting HIV integrase: QSAR study. Acta Pharm. 2009;59:31-43 pubmed publisher
    ..A detailed investigation was made of the structural basis for the antiretroviral activity and the findings from the study could be usefully employed to design antagonists with a much more enhanced potency and selectivity. ..
  76. Zhou Y, Rodriguez A, Williams R, Weaver C, Conn P, Lindsley C. Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009;19:6502-6 pubmed publisher
    ..This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and further examples of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold. ..
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    ..Condensation of 4a-g with omega-bromoalkoxyphthalimides 5a-b afforded the titled compounds 6a-n, some of which exhibited significant antimalarial as well as antimicrobial activity. ..
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    ..Further optimization studies focusing on the docking model of 15 in the active site of Chk1 revealed that 32b (IC(50)=2.8nM) was a more potent inhibitor than UNC-01. ..
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