ketoprofen

Summary

Summary: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.

Top Publications

  1. Amagai Y, Tanaka A, Matsuda A, Oida K, Jung K, Nishikawa S, et al. Topical application of ketoprofen improves gait disturbance in rat models of acute inflammation. Biomed Res Int. 2013;2013:540231 pubmed publisher
    ..The approach also indicated that ketoprofen is superior to other NSAIDs for providing pain relief because of its higher skin permeability...
  2. Neirinckx E, Croubels S, De Boever S, Remon J, Bosmans T, Daminet S, et al. Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen. Res Vet Sci. 2011;91:415-21 pubmed publisher
    ..elucidate frequent and species-specific causes of differences in oral bioavailability, a 3mg/kg dose of racemic ketoprofen, a high permeability/low solubility compound in the human biopharmaceutics classification system, was ..
  3. Salgado R, Pereira V, Carvalho G, Soeiro R, Gaffney V, Almeida C, et al. Photodegradation kinetics and transformation products of ketoprofen, diclofenac and atenolol in pure water and treated wastewater. J Hazard Mater. 2013;244-245:516-27 pubmed publisher
    Pharmaceutical compounds such as ketoprofen, diclofenac and atenolol are frequently detected at relatively high concentrations in secondary effluents from wastewater treatment plants...
  4. Mustonen K, Ala Kurikka E, Orro T, Peltoniemi O, Raekallio M, Vainio O, et al. Oral ketoprofen is effective in the treatment of non-infectious lameness in sows. Vet J. 2011;190:55-9 pubmed publisher
    The efficacy of ketoprofen in the treatment of non-infectious lameness in sows was examined in a double-blinded study. Two dose rates of oral ketoprofen were compared to placebo treatment over five consecutive days...
  5. Singh S, Gajra B, Rawat M, Muthu M. Enhanced transdermal delivery of ketoprofen from bioadhesive gels. Pak J Pharm Sci. 2009;22:193-8 pubmed
    ..of this study was to evaluate and compare the in vitro and in vivo transdermal potential of bioadhesive gels of ketoprofen by using gelling polymers like sodium carboxymethylcellulose, xanthan gum, poloxamer 407 and carbopol 934P as ..
  6. Nyangoga H, Aguado E, Goyenvalle E, Baslé M, Chappard D. A non-steroidal anti-inflammatory drug (ketoprofen) does not delay beta-TCP bone graft healing. Acta Biomater. 2010;6:3310-7 pubmed publisher
    ..Animals were studied after 8 and 28 days. Ketoprofen (a non-steroidal anti-inflammatory drug (NSAID)) was given for 8 and 28 days to evaluate its effects on the ..
  7. Shinkai N, Korenaga K, Mizu H, Yamauchi H. Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats. J Control Release. 2008;131:107-12 pubmed publisher
    The purpose of this study was to evaluate percutaneous penetration and pharmacological effects of ketoprofen after transdermal administration, compared to the oral route...
  8. Shukuri M, Takashima Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, et al. In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. J Nucl Med. 2011;52:1094-101 pubmed publisher
    ..However, the specific functions of these isoforms are still unclear. We recently developed (11)C-labeled ketoprofen methyl ester as a PET probe that targets the COXs for imaging neuroinflammation, though its responsible isoform ..
  9. Rutyna R, Popowicz M, Wojewoda P, Nestorowicz A, Białek W. [Pre-emptive ketoprofen for postoperative pain relief after urologic surgery]. Anestezjol Intens Ter. 2011;43:18-21 pubmed
    ..of non-steroidal antiinflammatory agents (NSAIDs) for pre-emptive analgesia, we assessed the efficacy of ketoprofen administered before urological surgery...

More Information

Publications65

  1. Shinkai N, Korenaga K, Okumura Y, Mizu H, Yamauchi H. Microdialysis assessment of percutaneous penetration of ketoprofen after transdermal administration to hairless rats and domestic pigs. Eur J Pharm Biopharm. 2011;78:415-21 pubmed publisher
    The study was performed to evaluate the percutaneous penetration of ketoprofen after transdermal administration using a microdialysis technique in pigs, in comparison with rats...
  2. Fosse T, Horsberg T, Haga H, Hormazabal V, Ranheim B. Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age. J Vet Pharmacol Ther. 2011;34:153-9 pubmed publisher
    Following intravenous dose of 6mg/kg racemic ketoprofen, the chiral pharmacokinetics of ketoprofen was investigated in eight piglets aged 6 and 21days old...
  3. Brogliato A, Antunes C, Carvalho R, Monteiro A, Tinoco R, Bozza M, et al. Ketoprofen impairs immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2. Shock. 2012;38:620-9 pubmed publisher
    ..The role of prostanoids was evaluated in vivo and in vitro by treatment with the cyclooxygenase inhibitor ketoprofen. Balb/c mice were more susceptible than C57BL/6 to severe sepsis and to secondary infection, with a greater ..
  4. Silion M, Hritcu D, Jaba I, Tamba B, Ionescu D, Mungiu O, et al. In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides. J Mater Sci Mater Med. 2010;21:3009-18 pubmed publisher
    b>Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method. The drug intercalation was confirmed by X-ray diffraction (XRD) and FTIR spectroscopy...
  5. Gao Y, Deshusses M. Adsorption of clofibric acid and ketoprofen onto powdered activated carbon: effect of natural organic matter. Environ Technol. 2011;33:1719-27 pubmed
    The adsorption of two acidic pharmaceutically active compounds (PhACs), clofibric acid and ketoprofen, onto powdered activated carbon (PAC) was investigated with a particular focus on the influence of natural organic matter (NOM) on the ..
  6. Cirri M, Maestrelli F, Mennini N, Mura P. Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids. J Pharm Biomed Anal. 2009;50:683-9 pubmed publisher
    Binary and ternary interaction products of ketoprofen (an anti-inflammatory drug very poorly water soluble) with phospholipids (phosphatidylcholine (EPC3) and phosphatidylglycerol (EPG)) and cyclodextrins (beta-cyclodextrin and its ..
  7. Liu S, Mizu H, Yamauchi H. Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression, and regulation of multiple signaling pathways. Free Radic Biol Med. 2010;48:772-80 pubmed publisher
    b>Ketoprofen (KP) is photolabile and undergoes degradation when irradiated by sunlight, causing the development of various skin diseases...
  8. Szabó R, Megyeri C, Illes E, Gajda Schrantz K, Mazellier P, Dombi A. Phototransformation of ibuprofen and ketoprofen in aqueous solutions. Chemosphere. 2011;84:1658-63 pubmed publisher
    The UV (254 nm) and UV/VUV (254/185 nm) photolysis of two anti-inflammatory drugs, ibuprofen and ketoprofen, have been studied in aqueous solutions as a possible process for the removal of non-biodegradable compounds...
  9. Oliveira R, Nascimento T, Lima E. Design and characterization of sustained release ketoprofen entrapped carnauba wax microparticles. Drug Dev Ind Pharm. 2012;38:1-11 pubmed publisher
    b>Ketoprofen is a non-steroid anti-inflammatory drug (NSAID) used in the treatment of rheumatic diseases and in mild to moderate pain...
  10. Yildiz N, Atalay N, Gungen G, Sanal E, Akkaya N, Topuz O. Comparison of ultrasound and ketoprofen phonophoresis in the treatment of carpal tunnel syndrome. J Back Musculoskelet Rehabil. 2011;24:39-47 pubmed publisher
    The aim of this study was to compare the efficacy of ultrasound (US) and ketoprofen phonophoresis (PH) in the treatment of carpal tunnel syndrome (CTS)...
  11. Sakeena M, Muthanna F, Ghassan Z, Kanakal M, Elrashid S, Munavvar A, et al. Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery. J Oleo Sci. 2010;59:223-8 pubmed
    ..present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was ..
  12. Del Gaudio P, Russo P, Rosaria Lauro M, Colombo P, Aquino R. Encapsulation of ketoprofen and ketoprofen lysinate by prilling for controlled drug release. AAPS PharmSciTech. 2009;10:1178-85 pubmed publisher
    In this paper, ketoprofen and ketoprofen lysinate were used as model drugs in order to investigate release profiles of poorly soluble and very soluble drug from sodium alginate beads manufactured by prilling...
  13. Nakamura K, Radhakrishnan K, Wong Y, Rockson S. Anti-inflammatory pharmacotherapy with ketoprofen ameliorates experimental lymphatic vascular insufficiency in mice. PLoS ONE. 2009;4:e8380 pubmed publisher
    ..therapy in this disease, we examined the impact of a nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, and of a soluble TNF-alpha receptor (sTNF-R1) upon tumor necrosis factor (TNF)-alpha activity in a mouse model ..
  14. Atarashi K, Mori T, Yoshiki R, Kabashima K, Kuma H, Tokura Y. Skin application of ketoprofen systemically suppresses contact hypersensitivity by inducing CD4(+) CD25(+) regulatory T cells. J Dermatol Sci. 2009;53:216-21 pubmed publisher
    b>Ketoprofen (KP) is a widely used nonsteroidal anti-inflammatory drug that inhibits prostaglandin biosynthesis...
  15. Horie M, Sekiya I, Nakamura T, Tanaka H, Maekawa K, Nakanishi M, et al. In vivo pharmacokinetics of ketoprofen after patch application in the Mexican hairless pig. Biopharm Drug Dispos. 2009;30:204-8 pubmed publisher
    ..A ketoprofen patch was applied on the back of Mexican hairless pigs for 24 h, followed by sequential collection of blood ..
  16. Cirri M, Maestrelli F, Mennini N, Mura P. Influence of the preparation method on the physical-chemical properties of ketoprofen-cyclodextrin-phosphatidylcholine ternary systems. J Pharm Biomed Anal. 2009;50:690-4 pubmed publisher
    ..the effectiveness and actual advantages of the microwave (MW) technology for preparing ternary complexes of ketoprofen (Keto) with beta-cyclodextrin (beta-Cd) or methylated-beta-cyclodextrin (Mebeta-Cd) and phosphatidylcholine (..
  17. Naidoo V, Venter L, Wolter K, Taggart M, Cuthbert R. The toxicokinetics of ketoprofen in Gyps coprotheres: toxicity due to zero-order metabolism. Arch Toxicol. 2010;84:761-6 pubmed publisher
    In a safety study, Cape Griffon vultures (Gyps coprotheres) were dosed with ketoprofen at single doses of ~1 mg/kg (n = 5) and 5 mg/kg (n = 11). No toxicity was reported in the 1 mg/kg group, with the AUC(inf), V(z) and Cl being 10...
  18. Yu D, Yu J, Chen L, Williams G, Wang X. Modified coaxial electrospinning for the preparation of high-quality ketoprofen-loaded cellulose acetate nanofibers. Carbohydr Polym. 2012;90:1016-23 pubmed publisher
    ..With CA employed as a filament-forming matrix and ketoprofen (KET) as an active pharmaceutical ingredient, modified coaxial processes using sheath fluids comprising only ..
  19. Shientag L, Wheeler S, Garlick D, Maranda L. A therapeutic dose of ketoprofen causes acute gastrointestinal bleeding, erosions, and ulcers in rats. J Am Assoc Lab Anim Sci. 2012;51:832-41 pubmed
    Perioperative treatment of several rats in our facility with ketoprofen (5 mg/kg SC) resulted in blood loss, peritonitis, and death within a day to a little more than a week after surgery that was not related to the gastrointestinal tract...
  20. Shi D, Jin Y, Tang Y, Hu H, Xu S, Yu L, et al. Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains. Acta Pharmacol Sin. 2012;33:710-6 pubmed publisher
    To investigate the stereoselective binding of mexiletine or ketoprofen enantiomers with different recombinant domains of human serum albumin (HSA).
  21. Giraudel J, Gruet P, Alexander D, Seewald W, King J. Evaluation of orally administered robenacoxib versus ketoprofen for treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. Am J Vet Res. 2010;71:710-9 pubmed publisher
    ..0 to 2.4 mg of robenacoxib/kg, q 12 h [daily dosage, 2.0 to 4.8 mg/kg]), and group 3 (ketoprofen [mean dosage, 1 mg/kg, q 24 h]). All cats were administered tablets PO for 5 or 6 days...
  22. Duffield T, Heinrich A, Millman S, Dehaan A, James S, Lissemore K. Reduction in pain response by combined use of local lidocaine anesthesia and systemic ketoprofen in dairy calves dehorned by heat cauterization. Can Vet J. 2010;51:283-8 pubmed
    This study assessed the efficacy of ketoprofen for mitigating pain following dehorning with an electric cautery iron...
  23. van der Heide H, Hannink G, Buma P, Schreurs B. No effect of ketoprofen and meloxicam on bone graft ingrowth: a bone chamber study in goats. Acta Orthop. 2008;79:548-54 pubmed publisher
    ..9 goats received no NSAIDs, 9 received ketoprofen, and 9 received meloxicam--all for 6 weeks...
  24. Kneer W, Rother I, Rother M, Seidel E. A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. Curr Drug Saf. 2009;4:5-10 pubmed
    ..Diractin (formerly IDEA-033) is a viscous, aqueous formulation for epicutaneous application of ketoprofen based on ultra-deformable, self-regulating carrier (Transfersome)...
  25. Naidoo V, Wolter K, Cromarty D, Diekmann M, Duncan N, Meharg A, et al. Toxicity of non-steroidal anti-inflammatory drugs to Gyps vultures: a new threat from ketoprofen. Biol Lett. 2010;6:339-41 pubmed publisher
    ..Here, we report on the safety testing of the NSAID ketoprofen, which was not reported to cause mortality in clinical treatment of scavenging birds and is rapidly eliminated ..
  26. Monti S, Ottani S, Manoli F, Manet I, Scagnolari F, Zambelli B, et al. Chiral recognition of 2-(3-benzoylphenyl)propionic acid (ketoprofen) by serum albumin: an investigation with microcalorimetry, circular dichroism and molecular modelling. Phys Chem Chem Phys. 2009;11:9104-13 pubmed publisher
    The interaction of enantiomeric ketoprofen (KP) with BSA and HSA was studied by isothermal titration calorimetry (ITC). Affinity constants and thermodynamic parameters for complexation in two main protein sites were determined...
  27. Ni Z, Zhou P, Jin X, Lin X. Integrating In Silico and In vitro approaches to dissect the stereoselectivity of Bacillus subtilis lipase A toward ketoprofen vinyl ester. Chem Biol Drug Des. 2011;78:301-8 pubmed publisher
    ..subtilis lipase A, as a model enzyme, is studied systematically to dissect its stereoselectivity toward (rac)-ketoprofen vinyl ester using a combination scheme of molecular docking and quantum mechanical/molecular mechanical (QM/MM) ..
  28. Tettey Amlalo R, Kanfer I, Skinner M, Benfeldt E, Verbeeck R. Application of dermal microdialysis for the evaluation of bioequivalence of a ketoprofen topical gel. Eur J Pharm Sci. 2009;36:219-25 pubmed publisher
    The purpose was to investigate dermal microdialysis (DMD) for the assessment of the bioavailability of a ketoprofen topical gel formulation and to evaluate this technique as a tool for the determination of bioequivalence...
  29. Fosse T, Toutain P, Spadavecchia C, Haga H, Horsberg T, Ranheim B. Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling. J Vet Pharmacol Ther. 2011;34:338-49 pubmed publisher
    The chiral pharmacokinetics and pharmacodynamics of ketoprofen were investigated in a placebo-controlled study in piglets after intramuscular administration of 6 mg/kg racemic ketoprofen...
  30. Westerén Punnonen S, Ypparila Wolters H, Partanen J, Nieminen K, Hyvärinen A, Kokki H. Somatosensory evoked potentials by median nerve stimulation in children during thiopental/sevoflurane anesthesia and the additive effects of ketoprofen and fentanyl. Anesth Analg. 2008;107:799-805 pubmed publisher
    ..In addition, the effects of two analgesics (ketoprofen and fentanyl) on SEPs were evaluated. Median nerve SEPs were recorded before premedication with midazolam 0...
  31. Combettes E, Benhamou D, Mazoit J, Beloeil H. Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. Eur J Anaesthesiol. 2010;27:642-7 pubmed
    ..or physiological saline); a left sciatic block (bupivacaine or physiological saline); and a systemic injection (ketoprofen or physiological saline)...
  32. Stigliani M, Aquino R, Del Gaudio P, Mencherini T, Sansone F, Russo P. Non-steroidal anti-inflammatory drug for pulmonary administration: design and investigation of ketoprofen lysinate fine dry powders. Int J Pharm. 2013;448:198-204 pubmed publisher
    ..The purpose of the present research was to produce respirable engineered particles of ketoprofen lysinate, a non-steroidal anti-inflammatory drug able to fight lung inflammatory status by direct administration ..
  33. Neirinckx E, Croubels S, Remon J, Devreese M, De Backer P, Vervaet C. Chiral inversion of R(-) to S(+) ketoprofen in pigs. Vet J. 2011;190:290-2 pubmed publisher
    The S(+) enantiomer of ketoprofen is predominant in the plasma of pigs after administration of racemic ketoprofen, although the occurrence and extent of R(-)-to-S(+) inversion is uncertain...
  34. Bartolucci P, el Murr T, Roudot Thoraval F, Habibi A, Santin A, Renaud B, et al. A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults. Blood. 2009;114:3742-7 pubmed publisher
    ..We conducted a phase 3, double-blind, randomized, placebo-controlled trial with ketoprofen (300 mg/day for 5 days), a nonselective cyclooxygenase inhibitor, for severe VOC in adults...
  35. Jin Y, Tang Y, Zeng S. Analysis of flurbiprofen, ketoprofen and etodolac enantiomers by pre-column derivatization RP-HPLC and application to drug-protein binding in human plasma. J Pharm Biomed Anal. 2008;46:953-8 pubmed publisher
    ..reversed-phase high-performance liquid chromatography (HPLC) assay to determine the enantiomers of flurbiprofen, ketoprofen and etodolac in human plasma was developed...
  36. Herwadkar A, Sachdeva V, Taylor L, Silver H, Banga A. Low frequency sonophoresis mediated transdermal and intradermal delivery of ketoprofen. Int J Pharm. 2012;423:289-96 pubmed publisher
    The objective of this study was to test low frequency sonophoresis at 20 kHz for delivery of ketoprofen into and across the skin...
  37. Izu K, Hino R, Isoda H, Nakashima D, Kabashima K, Tokura Y. Photocontact dermatitis to ketoprofen presenting with erythema multiforme. Eur J Dermatol. 2008;18:710-3 pubmed publisher
    A 74-year-old Japanese man developed erythema multiforme on the inner aspect of his left elbow where ketoprofen-containing tape was applied and exposed to sunlight, and the eruption subsequently spread to the four limbs and trunk...
  38. Api O, Ergen B, Api M, Ugurel V, Emeksiz M, Unal O. Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2010;203:28.e1-7 pubmed publisher
    ..We sought to investigate the analgesic efficacy of oral dexketoprofen trometamol and intrauterine lidocaine in patients undergoing fractional curettage...
  39. Shohin I, Kulinich J, Ramenskaya G, Abrahamsson B, Kopp S, Langguth P, et al. Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen. J Pharm Sci. 2012;101:3593-603 pubmed publisher
    ..vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed...
  40. Samulak D, Michalska M, Gaca M, Wilczak M, Mojs E, Chuchracki M. Efficiency of postoperative pain management after gynecologic oncological surgeries with the use of morphine + acetaminophen + ketoprofen versus morphine + metamizol + ketoprofen. Eur J Gynaecol Oncol. 2011;32:168-70 pubmed
    ..In the instances of pain rated at 5 or more, patients were additionally administered ketoprofen intravenously...
  41. Kim B, Won M, Lee K, Kim C. In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug. Drug Deliv. 2008;15:465-9 pubmed
    We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability...
  42. Kamei S, Sakayama K, Tamashiro S, Aizawa J, Miyawaki J, Miyazaki T, et al. Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma. J Orthop Res. 2009;27:909-15 pubmed publisher
    The aim of this study was to investigate whether ketoprofen (KP) in topical formulation affected the tumor growth and pulmonary metastasis of LM8 cells, which were inoculated subcutaneously into the back space of male nude mice...
  43. Shah P, Desai P, Singh M. Effect of oleic acid modified polymeric bilayered nanoparticles on percutaneous delivery of spantide II and ketoprofen. J Control Release. 2012;158:336-45 pubmed publisher
    ..bilayered nanoparticles (NPS) on combined delivery of two anti-inflammatory drugs, spantide II (SP) and ketoprofen (KP) on the skin permeation. NPS were prepared using poly(lactic-co-glycolic acid) (PLGA) and chitosan...
  44. Gigante A, Tagarro I. Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole. Clin Drug Investig. 2012;32:221-33 pubmed publisher
    ..prevention of NSAID-induced gastropathy, with a particular focus on the first fixed-dose NSAID/PPI formulation: ketoprofen/omeprazole modified-release capsules...
  45. Vučen S, Vuleta G, Crean A, Moore A, Ignjatovic N, Uskokovic D. Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. J Pharm Pharmacol. 2013;65:1451-62 pubmed publisher
    The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery.
  46. Martins T, Kahvegian M, Noel Morgan J, Leon Roman M, Otsuki D, Fantoni D. Comparison of the effects of tramadol, codeine, and ketoprofen alone or in combination on postoperative pain and on concentrations of blood glucose, serum cortisol, and serum interleukin-6 in dogs undergoing maxillectomy or mandibulectomy. Am J Vet Res. 2010;71:1019-26 pubmed publisher
    To compare analgesic effects of tramadol, codeine, and ketoprofen administered alone and in combination and their effects on concentrations of blood glucose, serum cortisol, and serum interleukin (IL)-6 in dogs undergoing maxillectomy or ..
  47. Kheradmandnia S, Vasheghani Farahani E, Nosrati M, Atyabi F. Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomedicine. 2010;6:753-9 pubmed publisher
    ..b>Ketoprofen as a model drug was incorporated into SLNs prepared from a mixture of beeswax and carnauba wax using Tween 80 ..
  48. Rodríguez M, Arbós R, Amaro S. Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller. Expert Rev Neurother. 2008;8:1625-40 pubmed publisher
  49. Sener M, Yilmazer C, Yilmaz I, Bozdogan N, Ozer C, Donmez A, et al. Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. J Clin Anesth. 2008;20:103-8 pubmed publisher
    To compare the efficacy of injectable lornoxicam with diclofenac, ketoprofen, and dipyrone for acute postoperative pain. Prospective, randomized, placebo-controlled, double-blind study. University hospital...
  50. Leman P, Kapadia Y, Herington J. Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury. Emerg Med J. 2003;20:511-3 pubmed
    ..88 (1.48 to 32.0), 3.79 (1.59 to 9.01), 5.19 (2.29 to 11.78), and 5.87 (2.68 to 12.88). Dexketoprofen trometamol is an effective and rapidly acting analgesic for the treatment of acute musculoskeletal injuries. ..
  51. Sutherland M, Mellor D, Stafford K, Gregory N, Bruce R, Ward R. Cortisol responses to dehorning of calves given a 5-h local anaesthetic regimen plus phenylbutazone, ketoprofen, or adrenocorticotropic hormone prior to dehorning. Res Vet Sci. 2002;73:115-23 pubmed
    ..purpose of this work was to assess whether the non-steroidal anti-inflammatory drugs (NSAIDs) phenylbutazone and ketoprofen, and an adrenocorticotropic hormone (ACTH) induced cortisol surge, reduce the cortisol response which occurs ..
  52. Barbanoj M, Antonijoan R, Gich I. Clinical pharmacokinetics of dexketoprofen. Clin Pharmacokinet. 2001;40:245-62 pubmed
    ..is a water-soluble salt of the dextrorotatory enantiomer of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. Racemic ketoprofen is used as an analgesic and an anti-inflammatory agent, and is one of the most potent in ..
  53. Skordi E, Wilson I, Lindon J, Nicholson J. Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy. Xenobiotica. 2005;35:715-25 pubmed
    ..The spontaneous degradation of the diastereoisomeric beta-1-O-acyl glucuronide metabolites of the racemic drug ketoprofen, two of its ring-hydroxylated metabolites and of tolmetin beta-1-O-acyl glucuronide was investigated by (1)H-NMR ..
  54. Rugyte D, Kokki H. Intravenous ketoprofen as an adjunct to patient-controlled analgesia morphine in adolescents with thoracic surgery: a placebo controlled double-blinded study. Eur J Pain. 2007;11:694-9 pubmed
    ..To evaluate the efficacy of intravenous ketoprofen, a NSAID, as an adjunct to PCA morphine in pain treatment in children having pectus surgery...
  55. Wang L, Chiang H, Wu P. Kinetics and hydrolysis mechanism of polymeric prodrugs containing ibuprofen, ketoprofen, and naproxen as pendent agents. J Biomater Sci Polym Ed. 2002;13:287-99 pubmed
    ..acid (MA) copolymerization with 2-hydroxyethyl methacrylate (HEMA), covalently linked with ibuprofen (HI), ketoprofen (HK), or naproxen (HN)...
  56. Wu P, Chang J, Huang Y, Chai C, Tsai Y. Evaluation of percutaneous absorption and skin irritation of ketoprofen through rat skin: in vitro and in vivo study. Int J Pharm. 2001;222:225-35 pubmed
    ..such as menthol, azone, ethanol and nonivarnide) regarding the percutaneous absorption and skin irritation of ketoprofen formulations through rat skin were investigated by in vitro and in vivo study...