Summary: A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
- Montero Melendez T, Forfar R, Cook J, Jerman J, Taylor D, Perretti M. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017;74:1335-1345 pubmed publisher..The non-steroidal anti-inflammatory drug fenoprofen, but not the similar compound ibuprofen, presented PAM activity at MC3, MC4, and MC5Tran N, Gin K. Occurrence and removal of pharmaceuticals, hormones, personal care products, and endocrine disrupters in a full-scale water reclamation plant. Sci Total Environ. 2017;599-600:1503-1516 pubmed publisher..Several ECs, such as acetaminophen, atenolol, fenoprofen, indomethacin, ibuprofen, and oxybenzone, exhibited excellent removal efficiencies (>90%) in biological ..Ask K, Øiestad E, Pedersen Bjergaard S, Gjelstad A. Dried blood spots and parallel artificial liquid membrane extraction-A simple combination of microsampling and microextraction. Anal Chim Acta. 2018;1009:56-64 pubmed publisher..In a second procedure, ketoprofen, fenoprofen, flurbiprofen, and ibuprofen (acidic model analytes) were desorbed from the DBS into 20?mM formic acid, ..El Assassy A, Amin M, Abdelbary A. Immediate release three-layered chewing gum tablets of fenoprofen calcium: preparation, optimization and bioavailability studies in healthy human volunteers. Drug Dev Ind Pharm. 2012;38:603-15 pubmed publisherA three-layered gum tablet (1800 mg), containing 200 mg of Fenoprofen Calcium (Fn) with an inner core containing the drug, and two external layers containing antiadherent lubricant, has been prepared using direct compression...Kameshwar V, R K, Priya B, Swamy S. Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A2 from Vipera russelli. Mol Cell Biochem. 2017;426:161-175 pubmed publisher..In this study, we have prepared the fenoprofen and ibuprofen analogs containing 1,3,4-oxadiazole nucleus and tested against Vipera russelli venom's basic sPLA<..Hercegova A, Sadecka J, Polonsky J. Determination of some antirheumatics by capillary isotachophoresis. Electrophoresis. 2000;21:2842-7 pubmedIsotachophoresis (ITP) was applied for the determination of some antirheumatic drugs (fenoprofen, naproxen, ibuprofen, and ketoprofen) in human serum. The leading electrolyte contained hydrochloric acid (10 mmol x L(-1)), creatinine (pH 4...Castro E, Soraci A, Fogel F, Tapia O. Chiral inversion of R(-) fenoprofen and ketoprofen enantiomers in cats. J Vet Pharmacol Ther. 2000;23:265-71 pubmed..In this study, R(-) fenoprofen [R(-)FPF] and R(-) ketoprofen [R(-) KTF] were used to investigate their comparative stereoconversion in cats...Stevenson C, Bennett D, Lechuga Ballesteros D. Pharmaceutical liquid crystals: the relevance of partially ordered systems. J Pharm Sci. 2005;94:1861-80 pubmedFarghaly D, Aboelwafa A, Hamza M, Mohamed M. Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation. AAPS PharmSciTech. 2017;18:2898-2909 pubmed publisher..was to investigate the potential of surfactant-based nanovesicular system (spanlastics) for topical delivery of fenoprofen calcium (FPCa) to eliminate its oral gastrointestinal adverse effects...Barissa G, Poggi J, Donadi E, Dos Reis M, Lanchote V. Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen. Chirality. 2004;16:602-8 pubmedTo investigate the influence of rheumatoid arthritis on the stereoselective disposition of fenoprofen administered as a racemic mixture, eight patients with rheumatoid arthritis receiving calcium rac-fenoprofen (200 mg/8 h) and 7 healthy ..Mohamed M, Frag E, Hathoot A, Shalaby E. Spectrophotometric determination of fenoprofen calcium drug in pure and pharmaceutical preparations. Spectroscopic characterization of the charge transfer solid complexes. Spectrochim Acta A Mol Biomol Spectrosc. 2018;189:357-365 pubmed publisherSimple, accurate and robust spectrophotometric method was developed for determination of fenoprofen calcium drug (FPC)...Knadler M, Hall S. Stereoselective arylpropionyl-CoA thioester formation in vitro. Chirality. 1990;2:67-73 pubmed..thioester formation was studied in rat tissue homogenates and subcellular fractions for the enantiomers of fenoprofen, ibuprofen, and flurbiprofen...Kemal C, Casida J. Coenzyme A esters of 2-aryloxyphenoxypropionate herbicides and 2-arylpropionate antiinflammatory drugs are potent and stereoselective inhibitors of rat liver acetyl-CoA carboxylase. Life Sci. 1992;50:533-40 pubmed..The CoA esters of the antiinflammatory drugs ibuprofen and fenoprofen also strongly inhibit this carboxylase. (S)-Ibuprofenyl-CoA (Ki = 0...Madikizela L, Tavengwa N, Chimuka L. Applications of molecularly imprinted polymers for solid-phase extraction of non-steroidal anti-inflammatory drugs and analgesics from environmental waters and biological samples. J Pharm Biomed Anal. 2018;147:624-633 pubmed publisher..Also, the lack of MIP applications to some compounds such as fenoprofen has been observed which is likely to be developed in the near future.Murillo Pulgarín J, Alañón Molina A, Sánchez Ferrer Robles I. Rapid simultaneous determination of four non-steroidal anti-inflammatory drugs by means of derivative nonlinear variable-angle synchronous fluorescence spectrometry. Appl Spectrosc. 2010;64:949-55 pubmed publisher..spectrofluorimetric method has been proposed for the simultaneous quantification of diflunisal, salicylic acid, fenoprofen, and 6-methoxy-2-naphthylacetic acid (6MNA)...Sevoz C, Rousselle C, Benoit E, Buronfosse T. In vitro study of fenoprofen chiral inversion in rat: comparison of brain versus liver. Xenobiotica. 1999;29:1007-16 pubmedThe extent and the overall stereoselectivity of the combined steps involved in the chiral inversion of fenoprofen, a non-steroidal anti-inflammatory drug, was investigated in rat brain microsomes and cytosol...Itagaki S, Gopal E, Zhuang L, Fei Y, Miyauchi S, Prasad P, et al. Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8). Pharm Res. 2006;23:1209-16 pubmed..Ibuprofen and other structurally related NSAIDs interact with hSMCT1 as blockers of its transport function rather than as its transportable substrates. ..Petrović M, Debeljak Z, Blazević N. Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters. J Pharm Biomed Anal. 2005;39:531-4 pubmed..chromatography (GC) method for enantioseparation of well-known non-steroidal anti-inflammatory drugs ibuprofen, fenoprofen and ketoprofen methyl esters mixture was developed...Baccari M, Calamai F, Staderini G. Depression by fenoprofen of the rebound contractions' elicited by vagal stimulation and arterial infusion of ATP in the rabbit stomach in vivo. Exp Physiol. 1990;75:415-8 pubmed..Administration of fenoprofen depressed or abolished the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal ..Diaz D, Escobar Llanos C, Bernad Bernad M. Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium. Drug Dev Ind Pharm. 1999;25:107-10 pubmedInteractions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR...De Craemer D, Van den Branden C, Pauwels M, Vamecq J. Peroxisome-proliferating effects of fenoprofen in mice. Lipids. 1998;33:539-43 pubmedWe report on hepatic effects obtained in vivo by treating mice with different doses of fenoprofen, an arylpropionic acid previously shown to inhibit in vitro peroxisomal very long chain fatty acid oxidation...Wang H, Zou H, Zhang Y. Multi-site binding of fenoprofen to human serum albumin studied by a combined technique of microdialysis with high performance liquid chromatography. Biomed Chromatogr. 1998;12:4-7 pubmedA simple and fast method for the determination of the multi-site binding of fenoprofen (FP) to human serum albumin (HSA) has been developed by utilizing microdialysis sampling techniques combined with high performance liquid ..Volland C, Benet L. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology. 1991;43:53-60 pubmedThe diastereomeric glucuronic acid conjugates are major metabolites of the nonsteroidal anti-inflammatory drug fenoprofen (FEN)...Simazaki D, Fujiwara J, Manabe S, Matsuda M, Asami M, Kunikane S. Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment. Water Sci Technol. 2008;58:1129-35 pubmed publisherRemoval property of nine pharmaceuticals (clofibric acid, diclofenac, fenoprofen, gemfibrozil, ibuprofen, indomethacin, ketoprofen, naproxen and propyphenazone) by chlorination, coagulation-sedimentation and powdered activated carbon ..Delbeke F, Debackere M. A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine. Biomed Chromatogr. 1994;8:29-31 pubmedA high performance liquid chromatographic method to measure plasma and urine fenoprofen levels in equine biofluids is described. Liquid-liquid extraction with diethylether was used to isolate the drug from plasma and urine...Poggi J, Barissa G, Donadi E, Foss M, Cunha F, Lanchote V, et al. Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. J Clin Pharmacol. 2006;46:1328-36 pubmed..of type 1 and type 2 diabetes mellitus on the enantioselective pharmacodynamics and pharmacokinetics of fenoprofen. Patients with diabetes mellitus type 1 (n = 7) or type 2 (n = 7) and healthy volunteers (n = 13) received ..Menzel Soglowek S, Geisslinger G, Brune K. Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column. J Chromatogr. 1990;532:295-303 pubmed..high-performance liquid chromatographic assay to determine the enantiomers of ketoprofen, ibuprofen and fenoprofen in plasma is presented...Soraci A, Benoit E, Delatour P. Comparative metabolism of R(-)-fenoprofen in rats and sheep. J Vet Pharmacol Ther. 1995;18:167-71 pubmed..It is a unique reaction specific to this group of drugs. In this study R-(-)-fenoprofen (R-(-)-FPF) was used as a model compound to investigate metabolic chiral inversion in sheep in vivo and in vitro ..Rollins D, Jennison T, Jones G. Investigation of interference by nonsteroidal anti-inflammatory drugs in urine tests for abused drugs. Clin Chem. 1990;36:602-6 pubmed..or 200 mg three times a day, or 400 mg three times a day, and in 42 patients taking ibuprofen, naproxyn, or fenoprofen in therapeutic regimens for more than 30 days...Pribová M, Gregorova J, Drsata J. Inhibition of aromatic amino acid decarboxylase by a group of non-steroidal anti-inflammatory drugs. Pharmacol Res. 1992;25:271-7 pubmed..flobufen and 2',4'-difluorobiphenyl-4-yl acetate) and propionic acid derivatives (ibuprofen, ketoprofen, fenoprofen) were one order weaker...Hall S, Hassanzadeh Khayyat M, Knadler M, Mayer P. Pulmonary inversion of 2-arylpropionic acids: influence of protein binding. Chirality. 1992;4:349-52 pubmed..5% bovine serum albumin or 5% dextran, were used to study the pulmonary elimination of (R)- and rac-ibuprofen, fenoprofen, and flurbiprofen...Shirey R, Morton S, Lawton K, Lowell C, Kickler T, Ness P. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol. 1988;89:410-4 pubmedA 70-year-old man developed severe immune intravascular hemolysis and renal failure following ingestion of fenoprofen, a nonsteroidal, anti-inflammatory drug. The patient's red blood cells were sensitized with both IgG and C3d...Hixson L, Alberts D, Krutzsch M, Einsphar J, Brendel K, Gross P, et al. Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Cancer Epidemiol Biomarkers Prev. 1994;3:433-8 pubmed..A cytostatic response was demonstrated with sulindac sulfide. These data further support the potential role of these agents for chemoprevention of colorectal neoplasia. ..Fujii A, Kuboyama N, Kobayashi S, Namiki Y, Tamura T. Time-course study of gastric damages in rats by anti-inflammatory drugs using a gastroscope and its quantification. Jpn J Pharmacol. 1988;48:317-22 pubmed..The peak CHIs of aspirin (300 mg/kg), indomethacin (60 mg/kg), mefenamic acid (300 mg/kg) and fenoprofen calcium (300 mg/kg) appeared approximately 24 hr after a single forced oral administration of drugs...Abd El Hady D, Youssef A. Hyphenation of ionic liquid albumin glassy carbon biosensor or protein label-free sensor with differential pulse stripping voltammetry for interaction studies of human serum albumin with fenoprofen enantiomers. Anal Chim Acta. 2013;772:68-74 pubmed publisher..A rapid, simple and reliable method for the chiral discrimination and real time protein binding studies of fenoprofen enantiomers with HSA was developed by hyphenating ionic liquid albumin glassy carbon (ILAGC) biosensor with ..Botello I, Borrull F, Aguilar C, Calull M. Electrokinetic supercharging focusing in capillary zone electrophoresis of weakly ionizable analytes in environmental and biological samples. Electrophoresis. 2010;31:2964-73 pubmed publisherFive non-steroidal anti-inflammatory drugs, naproxen, fenoprofen, ketoprofen, diclofenac and piroxicam, were separated and analyzed by electrokinetic supercharging in CZE...Choi Y, Yang C, Kim H, Jung S. Monte Carlo simulations of the chiral recognition of fenoprofen enantiomers by cyclomaltoheptaose (beta-cyclodextrin). Carbohydr Res. 2000;328:393-7 pubmedDifferential complexation of fenoprofen enantiomers by cyclomaltoheptaose (beta-cyclodextrin) was investigated by Monte Carlo docking simulations...Roberts B, Knights K. Inhibition of rat peroxisomal palmitoyl-CoA ligase by xenobiotic carboxylic acids. Biochem Pharmacol. 1992;44:261-7 pubmed..inhibition of the high affinity form was observed with the 2-arylpropionates, ibuprofen, naproxen, benoxaprofen, fenoprofen, indoprofen, ketoprofen, tiaprofenic acid and cicloprofen, the hypolipidaemics, nafenopin and ciprofibrate, and ..Uccello Barretta G, Chiavacci C, Bertucci C, Salvadori P. Stereochemistry and dynamics of the inclusion complex of (S)-(+)-fenoprofen with cyclomaltoheptaose (beta-cyclodextrin). Carbohydr Res. 1993;243:1-10 pubmed..Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular 1H(1H)-NOE enhancements revealed the stereochemistry in solution. ..Volland C, Sun H, Benet L. Stereoselective analysis of fenoprofen and its metabolites. J Chromatogr. 1990;534:127-38 pubmedReversed-phase high-performance liquid chromatographic assays have been developed to quantitate simultaneously fenoprofen and its major metabolites as well as to distinguish between their R- and S- enantiomers following a single oral dose ..Benoit E, Delatour P, Olivier L, Caldwell J. (-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes. Biochem Pharmacol. 1995;49:1717-20 pubmedThe thioesterification of fenoprofen (FPF) by rat liver microsomes has been studied using an HPLC method enabling direct quantification of the FPF-CoA produced...Borga O, Borgå B. Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study. J Pharmacokinet Biopharm. 1997;25:63-77 pubmed..The following fumin values were calculated: diclofenac 0.21%; fenoprofen 0.25%, flurbiprofen 0.022%, ketoprofen 0.52%, naproxen 0.039%, and tolmetin 0.37%...Dasgupta A, Emerson L. Interaction of valproic acid with nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen in normal and uremic sera: lack of interaction in uremic sera due to the presence of endogenous factors. Ther Drug Monit. 1996;18:654-9 pubmed..The nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen are also strongly bound to albumin...Soraci A, Benoit E. In vitro fenoprofenyl-coenzyme A thioester formation: interspecies variations. Chirality. 1995;7:534-40 pubmedIn vitro coenzyme A thioester formation from (-)-(R)-fenoprofen (FPF) and palmitic acid has been studied using liver microsomes from rat, guinea pig, sheep, and dog...Volland C, Sun H, Dammeyer J, Benet L. Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein. Drug Metab Dispos. 1991;19:1080-6 pubmedStereoselective degradation of fenoprofen (FEN) glucuronides and irreversible binding of FEN enantiomers to human serum albumin via their glucuronides were studied...Bertucci C. Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholate. Chirality. 2001;13:372-8 pubmedMiners J, Lillywhite K. Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity. Biochem Pharmacol. 1991;41:838-41 pubmed..However, confirmation of this ultimately requires studies to be performed with purified isozymes, cDNAs expressed in cell culture, or specific inhibitory antibodies. ..Rades T, Mueller Goymann C. Interactions between fenoprofen sodium and poly (ethylene oxide). Eur J Pharm Biopharm. 1998;46:51-9 pubmedInteractions of the amphiphilic drug fenoprofen sodium (FNa) in solution below and above its critical micelle concentration with poly (ethylene oxide) (PEO) of different chain length (PEO 400 to PEO 20000) and between a liquid crystalline ..San Martin M, Soraci A, Fogel F, Tapia O, Islas S. Chiral inversion of (R)-(-)-fenoprofen in guinea-pigs pretreated with clofibrate. Vet Res Commun. 2002;26:323-32 pubmedThe influence of clofibrate on the stereoconversion of fenoprofen (FPF) was studied in guinea pigs. This hypolipidaemic agent has been related to some biochemical changes in the liver leading to an increase in the chiral inversion process...Patterson J, Bary A, Rades T. Physical stability and solubility of the thermotropic mesophase of fenoprofen calcium as pure drug and in a tablet formulation. Int J Pharm. 2002;247:147-57 pubmed..study was to investigate and compare the physical stability and solubility of the liquid crystalline form of fenoprofen calcium as pure drug and in a proprietary tablet formulation (Nalfon), and to investigate if a simple heat ..Marjanović M, Zorc B, Pejnović L, Zovko M, Kralj M. Fenoprofen and ketoprofen amides as potential antitumor agents. Chem Biol Drug Des. 2007;69:222-6 pubmed..b>Fenoprofen and ketoprofen showed modest antiproliferative activity, whereas the growth inhibitory activity of the tested ..Yamada H, Masuda K, Ishige T, Fujii K, Uekusa H, Miura K, et al. Potential of synchrotron X-ray powder diffractometry for detection and quantification of small amounts of crystalline drug substances in pharmaceutical tablets. J Pharm Biomed Anal. 2011;56:448-53 pubmed publisher..b>Fenoprofen calcium dihydrate was used as a model compound...Duan W, Shen C, Fang H, Li G. Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior. Carbohydr Res. 2009;344:9-13 pubmed publisher..The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied...Soraci A, Jaussaud P, Benoit E, Delatour P. Chiral inversion of fenoprofen in horses and dogs: an in vivo-in vitro study. Vet Res. 1996;27:13-22 pubmedb>Fenoprofen (FPF) is a chiral non-steroid antiinflammatory drug, marketed as a racemic mixture of its R(-) and S(+) enantiomers...Mehvar R, Jamali F. Stereospecific high-performance liquid chromatographic (HPLC) assay of fenoprofen enantiomers in plasma and urine. Pharm Res. 1988;5:53-6 pubmedA new high-performance liquid chromatographic (HPLC) assay suitable for pharmacokinetic studies of enantiomers of fenoprofen (FEN) was developed...Elliott G, Purmalis A, VanderMeer D, Denlinger R. The propionic acids. Gastrointestinal toxicity in various species. Toxicol Pathol. 1988;16:245-50 pubmed..This paper discusses observations made on fenoprofen, flurbiprofen, ibuprofen and naproxen...Kakodkar S, Zief M. Resolution of derivatized acids and amines on JTB-X: a new urea bonded chiral stationary phase. Chirality. 1990;2:124-7 pubmed..Typical alpha-value for dinitrobenzoyl phenylglycine was 1.7. Values for derivatized ibuprofen, naproxen, and fenoprofen were 2, 1.84, and 1.6, respectively...Eccleston C, Cooper T, Fisher E, Anderson B, Wilkinson N. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017;8:CD012537 pubmed publisher..Participants reporting an adverse event (one or more per person) by drug were: aspirin 85/202; fenoprofen 28/49; ibuprofen 40/45; indomethacin 9/30; ketoprofen 9/30; meloxicam 18/47; naproxen 44/202; and rofecoxib 47/..Lageweg W, Wanders R. Studies on the effect of fenoprofen on the activation and oxidation of long chain and very long chain fatty acids in hepatocytes and subcellular fractions from rat liver. Biochem Pharmacol. 1993;46:79-85 pubmedWe studied the effect of fenoprofen on the activation of palmitic acid (C16:0), lignoceric acid (C24:0) and cerotic acid (C26:0) in microsomal and peroxisomal fractions from rat liver...Stephenson G, Diseroad B. Structural relationship and desolvation behavior of cromolyn, cefazolin and fenoprofen sodium hydrates. Int J Pharm. 2000;198:167-77 pubmedThe hydrated crystal structures of cromolyn, cefazolin, and fenoprofen sodium salts are reported...Segelman A. Oral manifestations of drug therapies in the geriatric patient. Dent Clin North Am. 1989;33:67-73 pubmedBischer A, Iwaki M, Zia Amirhosseini P, Benet L. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos. 1995;23:900-3 pubmedThe stereoselective binding of fenoprofen enantiomers and fenoprofen glucuronide diastereomers to human serum albumin (HSA) was investigated using an ultrafiltration method...Zhu H, Xu J, Varlashkin P, Long S, Kidd C. Dehydration, hydration behavior, and structural analysis of fenoprofen calcium. J Pharm Sci. 2001;90:845-59 pubmedb>Fenoprofen calcium (FC) is a nonsteroidal, anti-inflammatory, analgesic, and antipyretic agent...Sattari S, Jamali F. Involvement of the rat gut epithelial and muscular layer, and microflora in chiral inversion and acyl-glucuronidation of R-fenoprofen. Eur J Drug Metab Pharmacokinet. 1997;22:97-101 pubmedIn the presence of excised human and rat gut, the pharmacologically inactive R enantiomers of both ibuprofen and fenoprofen (FN) are bioinverted to their anti-inflammatory antipodes...Yamamoto T, Matsuura K, Shintani S, Hara A, Miyabe Y, Sugiyama T, et al. Dual effects of anti-inflammatory 2-arylpropionic acid derivatives on a major isoform of human liver 3alpha-hydroxysteroid dehydrogenase. Biol Pharm Bull. 1998;21:1148-53 pubmed..Flurbiprofen, fenoprofen, ibuprofen, naproxen, ketoprofen and suprofen stimulated the activity of the human enzyme (1.5-2...Kamaruddin A, Uzir M, Aboul Enein H, Halim H. Chemoenzymatic and microbial dynamic kinetic resolutions. Chirality. 2009;21:449-67 pubmed publisher..Future developments in novel reactions and products of dynamic kinetic resolutions should consider factors that are needed to be extracted at the early synthetic stage to avoid inhibition at scale-up stage have been highlighted. ..James M, Heald G, Shorter J, Turner R. Joint space measurement in hand radiographs using computerized image analysis. Arthritis Rheum. 1995;38:891-901 pubmed..Computerization permits sensitive JS measurement and should be of benefit in studies of early joint disease. ..Sivaprasad S, Bunce C, Crosby Nwaobi R. Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database Syst Rev. 2012;:CD004239 pubmed publisher..Indomethacin was used orally and was found to be ineffective for chronic CMO in one trial. Topical fenoprofen appeared effective but not statistically significantly so for chronic CMO in another small trial...Kantoci D, Wechter W. Calculation of inversion half-lives of aryl propionic acid class nonsteroidal antiinflammatory drugs. J Clin Pharmacol. 1996;36:500-4 pubmed..animal data, we have mathematically determined the inversion half-life (t1/2i) for ibuprofen, ketoprofen, and fenoprofen. The relation of the sensitivity of this value to the terminal half-life (t1/2) of the R-enantiomers of APA ..Sallustio B, Meffin P, Thompson M. High-performance liquid chromatographic quantitation of triacylglycerols containing fenoprofen from biological samples. J Chromatogr. 1987;422:33-41 pubmed..HPLC) method has been developed for the quantitation of radiolabelled triacylglycerols containing fenoprofen, synthesized from [3H]glycerol by isolated hepatocytes and adipocytes...Panus P, Tober Meyer B, Ferslew K. Tissue extraction and high-performance liquid chromatographic determination of ketoprofen entantiomers. J Chromatogr B Biomed Sci Appl. 1998;705:295-302 pubmed..This represents the first non-radioactive method for determination of ketoprofen in tissues following transcutaneous iontophoresis. ..Zhao C, He Z, Cui S, Tang X, Zhang R. [Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix]. Yao Xue Xue Bao. 2001;36:63-6 pubmedTo study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcellulose (HPMC) matrices. The release of FC and the erosion properties of hydrophillic matrices containing HPMC was examined at different paddle speed...Sadecka J, Hercegova A, Polonsky J. Determination of fenoprofen in serum by capillary isotachophoresis. J Chromatogr B Biomed Sci Appl. 1999;729:11-7 pubmedA isotachophoretic method with conductivity detection was developed and validated to directly determine fenoprofen in human serum. The leading electrolyte contained hydrochloric acid (10 mmol/l), 6-aminocaproic acid (pH 4...Cristófani Poggi J, Barissa G, Donadi E, Lanchote V, Lemos dos Reis M. Enantioselective kinetic disposition of fenoprofen in rats with experimental diabetes or adjuvant-induced arthritis. Pharmacology. 2004;72:85-91 pubmed..investigate the influence of diabetes or arthritis on the enantioselective metabolism and kinetic disposition of fenoprofen in rats with streptozotocin-induced diabetes or Mycobacteriumtuberculosis adjuvant-induced arthritis...Sallustio B, Meffin P, Knights K. The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols. Biochem Pharmacol. 1988;37:1919-23 pubmedThe formation of triacylglycerols containing fenoprofen was studied in rat isolated adipocytes and hepatocytes incubated with [3H]glycerol and R or S fenoprofen...Wang Z, Liu C, Kang J. A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration. J Chromatogr A. 2011;1218:1775-9 pubmed publisherA highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed...