aurintricarboxylic acid

Summary

Summary: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.

Top Publications

  1. Kusaka K, Tada Y, Shigemi T, Sakamoto M, Nakayashiki H, Tosa Y, et al. Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis. FEBS Lett. 2004;578:363-7 pubmed
    ..Interestingly, this finding is contrasted with those in well-studied animal cell-free systems in which an apoptotic endonuclease is solely responsible for the DNA fragmentation. ..
  2. Yap Y, Zhang X, Andonov A, He R. Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins. Comput Biol Chem. 2005;29:212-9 pubmed
    We recently published experimental results that indicated Aurintricarboxylic Acid (ATA) could selectively inhibit SARS-CoV replication inside host cells by greater than 1000 times...
  3. Cho H, Lee D, Shrestha S, Shim Y, Kim K, Kim M, et al. Aurintricarboxylic acid translocates across the plasma membrane, inhibits protein tyrosine phosphatase and prevents apoptosis in PC12 cells. Mol Cells. 2004;18:46-52 pubmed
    b>Aurintricarboxylic acid (ATA) prevents apoptosis in a diverse range of cell types including PC12 cells...
  4. He R, Adonov A, Traykova Adonova M, Cao J, Cutts T, Grudesky E, et al. Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid. Biochem Biophys Res Commun. 2004;320:1199-203 pubmed
    ..In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV ..
  5. Gao X, Margolis R, Leeds P, Hough C, Post R, Chuang D. Carbamazepine induction of apoptosis in cultured cerebellar neurons: effects of N-methyl-D-aspartate, aurintricarboxylic acid and cycloheximide. Brain Res. 1995;703:63-71 pubmed
    ..b>Aurintricarboxylic acid (ATA), a polyanionic dye, also markedly suppressed DNA fragmentation and cell death detected by ..
  6. Rui H, Xu J, Mehta S, Fang H, Williams J, Dong F, et al. Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. J Biol Chem. 1998;273:28-32 pubmed
    ..Here we demonstrate that a single Jak-Stat pathway can be activated by aurintricarboxylic acid (ATA), a negatively charged triphenylmethane derivative (475 Da) with anti-apoptotic properties...
  7. Hung H, Tseng C, Yang J, Ju Y, Tseng S, Chen Y, et al. Aurintricarboxylic acid inhibits influenza virus neuraminidase. Antiviral Res. 2009;81:123-31 pubmed publisher
    ..We found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC(50)s (..
  8. Haimsohn M, Beery R, Karasik A, Kanety H, Geier A. Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. Endocrinology. 2002;143:837-45 pubmed
    b>Aurintricarboxylic acid (ATA), a polymeric carboxylated triphenylmethane derivate, prevents apoptotic death in a variety of cell systems...
  9. Tsi C, Chao Y, Chen C, Lin W. Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinas. Mol Pharmacol. 2002;62:90-101 pubmed
    To elucidate the mechanisms involved in cell protection by aurintricarboxylic acid (ATA), an endonuclease inhibitor, high nitric oxide (NO)-induced macrophage apoptosis was studied. In RAW 264...

More Information

Publications62

  1. Fraifeld V, Seidman R, Sagi O, Muradian K, Wolfson M. Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells. Anticancer Res. 2001;21:1975-8 pubmed
    The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells...
  2. Beery R, Haimsohn M, Wertheim N, Hemi R, Nir U, Karasik A, et al. Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Endocrinology. 2001;142:3098-107 pubmed
    b>Aurintricarboxylic acid (ATA), an endonuclease inhibitor, prevents the death of a variety of cell types in culture...
  3. Chen Y, Bopda Waffo A, Basu A, Krishnan R, Silberstein E, Taylor D, et al. Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor. Antivir Chem Chemother. 2009;20:19-36 pubmed publisher
    ..b>Aurintricarboxylic acid (ATA), a broad-spectrum antiviral agent, was evaluated and characterized for its anti-NS5B activity in ..
  4. Matsuno H, Kozawa O, Niwa M, Tanabe K, Ichimaru K, Takiguchi Y, et al. Multiple inhibition of platelet activation by aurintricarboxylic acid prevents vascular stenosis after endothelial injury in hamster carotid artery. Thromb Haemost. 1998;79:865-71 pubmed
    Activated platelets are instrumental in restenosis due to their role in thrombus formation. Aurintricarboxylic acid (ATA) has been reported to prevent platelet activation by inhibiting von Willebrand factor binding to platelet ..
  5. Hashem A, Flaman A, Farnsworth A, Brown E, Van Domselaar G, He R, et al. Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PLoS ONE. 2009;4:e8350 pubmed publisher
    ..While vaccines are effective, they have a number of limitations, and influenza strains resistant to currently available anti-influenza drugs are increasingly isolated. This necessitates the exploration of novel anti-influenza therapies...
  6. Hung H, Chen T, Fang M, Yen K, Shih S, Hsu J, et al. Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid. J Antimicrob Chemother. 2010;65:676-83 pubmed publisher
    ..The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism...
  7. Walther W, Stein U, Siegel R, Fichtner I, Schlag P. Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection. J Gene Med. 2005;7:477-85 pubmed
    ..Therefore, inhibition of nuclease-mediated DNA degradation by the nuclease inhibitor aurintricarboxylic acid (ATA) might lead to improved gene transfer efficiency in tumor tissues...
  8. Myskiw C, Deschambault Y, Jefferies K, He R, Cao J. Aurintricarboxylic acid inhibits the early stage of vaccinia virus replication by targeting both cellular and viral factors. J Virol. 2007;81:3027-32 pubmed
    b>Aurintricarboxylic acid (ATA) has been shown to inhibit the replication of viruses from several different families, including human immunodeficiency virus, vesicular stomatitis virus, and the coronavirus causing severe acute respiratory ..
  9. Chen C, Chao Y, Chang Y, Hsu M, Lin W. Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid. Br J Pharmacol. 2002;137:1011-20 pubmed
    ..In previous study, we have found that the endonuclease inhibitor aurintricarboxylic acid (ATA) can protect macrophages from cell death induced by bacterial lipopolysaccharide...
  10. Heiduschka P, Thanos S. Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid. Graefes Arch Clin Exp Ophthalmol. 2006;244:1512-21 pubmed
    ..We have demonstrated previously significant neuroprotective properties of the anti-apoptotic drug aurintricarboxylic acid in the model of axotomised retinal ganglion cells...
  11. Wei Y, Kang Z, Qi X, Mo L, Liu C, Zhou Q. [Resonance light scattering of aurintricarboxylic acid]. Guang Pu Xue Yu Guang Pu Fen Xi. 2003;23:115-8 pubmed
    Resonance light scattering (RLS), absorption and fluorescence spectra of aurintricarboxylic acid (ATA) were studied. In solutions with pH 3.7 to pH 11...
  12. Damian L, Marty Detraves C, Winterhalter M, Fournier D, Paquereau L. Single-strand DNA translation initiation step analyzed by Isothermal Titration Calorimetry. Biochem Biophys Res Commun. 2009;385:296-301 pubmed publisher
    ..The binding specificity was confirmed by antibiotic interferences which block the initiation complex formation. These results suggest that the limiting step in translation of ssDNA is the elongation process. ..
  13. Morris E, Geller H. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol. 1996;134:757-70 pubmed
    ..DNA fragmentation was also confirmed by the use of the in situ DNA end labeling assay. In addition, aurintricarboxylic acid, an inhibitor of the apoptotic endonuclease, partially protected against camptothecin-induced neuronal ..
  14. Zhan P, Li Z, Liu X. Cosalane and its analogues: a unique class of anti-HIV agents. Mini Rev Med Chem. 2010;10:966-76 pubmed
  15. Nar H, Messerschmidt A, Huber R, van de Kamp M, Canters G. Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip. J Mol Biol. 1991;221:765-72 pubmed
    ..The structure of the remainder of the azurin molecule, including the copper binding site, is not significantly affected by this transition. ..
  16. Blomberg P, Eskandarpour M, Xia S, Sylven C, Islam K. Electroporation in combination with a plasmid vector containing SV40 enhancer elements results in increased and persistent gene expression in mouse muscle. Biochem Biophys Res Commun. 2002;298:505-10 pubmed
    ..have also studied the effects of the vehicle in which the plasmid was delivered, and the DNase inhibitor aurintricarboxylic acid (ATA), on gene expression...
  17. Heiduschka P, Romann I, Stieglitz T, Thanos S. Perforated microelectrode arrays implanted in the regenerating adult central nervous system. Exp Neurol. 2001;171:1-10 pubmed
    ..The number of regenerating cells could be enhanced by injecting neuroprotective drugs like aurintricarboxylic acid and cortisol intravitreally...
  18. Deng X, Ruvolo P, Carr B, May W. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci U S A. 2000;97:1578-83 pubmed
    ..These data indicate a role for a stauro-resistant Bcl2 kinase (SRK). We show that aurintricarboxylic acid (ATA), a nonpeptide activator of cellular MEK/mitogen-activated protein kinase (MAPK) kinase, can induce ..
  19. Lee M, Guo J, Schwab C, McGeer E, McGeer P. Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex. Neurobiol Aging. 2012;33:2237-46 pubmed publisher
    ..Aurin tricarboxylic acid, aurin quadracarboxylic acid, and aurin hexacarboxylic acid may be effective therapeutic agents in Alzheimer disease and other degenerative disorders where self damage from the MAC occurs. ..
  20. Lu H, Wei G, Wang D, Yung P, Ying W. Posttreatment with the Ca(2+)-Mg(2+)-dependent endonuclease inhibitor aurintricarboxylic acid abolishes genotoxic agent-induced nuclear condensation and DNA fragmentation and decreases death of astrocytes. J Neurosci Res. 2008;86:2925-31 pubmed publisher
    ..and the DNA fragmentation were abolished by posttreatment of the cells with the CME inhibitor aurintricarboxylic acid (ATA). The ATA posttreatment also significantly, but only partially, decreased MNNG-induced cell death...
  21. Stoetzer O, Pogrebniak A, Pelka Fleischer R, Hasmann M, Hiddemann W, Nuessler V. Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity. Biochem Pharmacol. 2002;63:471-83 pubmed
    ..05). The protective effect of FCCP was, however, transient and lasted only 6 hr. Treatment with aurintricarboxylic acid completely prevented Che- and Sts-induced apoptotic cell death in CCRF-CEM and HL60 cells...
  22. Smee D, Hurst B, Wong M. Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice. Antivir Chem Chemother. 2010;20:201-5 pubmed publisher
    b>Aurintricarboxylic acid (ATA) and ethacrynic acid (ECA) have been reported to exhibit antiviral activity against vaccinia virus infections in cell culture by inhibiting early and late gene transcription, respectively...
  23. Gammon G, Chandler G, Depledge P, Elcock C, Wrigley S, Moore J, et al. A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules. Eur J Immunol. 1994;24:991-8 pubmed
    ..411F has the potential for development as an immunosuppressive agent with a novel mechanism of action. ..
  24. MacKeen L, Kahan L, Wahba A, Schwartz I. Photochemical cross-linking of initiation factor-3 to Escherichia coli 30 S ribosomal subunits. J Biol Chem. 1980;255:10526-31 pubmed
    ..5 M NH4Cl or 0.5 mM aurintricarboxylic acid. Covalent attachment reached its maximum level of 8...
  25. Clemetson K, Clemetson J. Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 2008;99:473-9 pubmed publisher
  26. Jasmer D, Kwak D. Fusion and differentiation of murine C2C12 skeletal muscle cells that express Trichinella spiralis p43 protein. Exp Parasitol. 2006;112:67-75 pubmed
    ..These effects may result from similarities of Tsp43 to DNase II. Use of the general DNase inhibitor aurintricarboxylic acid (ATA) enhanced expression of MYC-Tsp43 in transfected muscle cells...
  27. Kim H, Kim J, Wi H, Lee S, Kim J, Kang H, et al. Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation. Xenotransplantation. 2008;15:246-56 pubmed publisher
    ..We investigated the potential protective effect of aurintricarboxylic acid (ATA), a known inhibitor of platelet adhesion, on endothelial damage induced by xenogeneic serum...
  28. Gerber A, Masuno K, Diamond M. Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009;106:4929-34 pubmed publisher
    ..Our results have important implications for the development of GR modulators and the identification of cross-talk pathways that control selective GR gene regulation...
  29. Weaver J, Gergely P, Pine P, Patzer E, Aszalos A. Polyionic compounds selectively alter availability of CD4 receptors for HIV coat protein rgp120. AIDS Res Hum Retroviruses. 1990;6:1125-30 pubmed
    ..Studies using a number of membrane-active drugs showed that changes in membrane potential or ion fluxes were not involved in the inhibition of binding of rgp120 by Evans blue or aurin tricarboxylic acid. ..
  30. De Castro S, Pinto M, Pinto A. Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship. Microbios. 1994;78:83-90 pubmed
  31. Hugunin M, Quintal L, Mankovich J, Ghayur T. Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product. J Biol Chem. 1996;271:3517-22 pubmed
    ..b>Aurintricarboxylic acid, an inhibitor of apoptosis in mammalian cells, blocked Ced-3 autocatalytic activity, suggesting that an ..
  32. Mouratou B, Rouyre S, Pauillac S, Guesdon J. Development of nonradioactive microtiter plate assays for nuclease activity. Anal Biochem. 2002;309:40-7 pubmed
    ..these two assays by measuring S1 nuclease and DNase I activities, and the inhibitory effect of EDTA and aurintricarboxylic acid on the reaction...
  33. Hoffman E, Conley S, Stamer W, McKay B. Barriers to productive transfection of trabecular meshwork cells. Mol Vis. 2005;11:869-75 pubmed
    ..In some experiments, cells were treated with a DNase I inhibitor, 100 nM aurintricarboxylic acid. Uptake of plasmid DNA was measured by intracellular fluorescence of Cy3 and productive transfection ..
  34. Ogata K, Ohno R, Terao K, Iwasaki K, Endo Y. ATPase associated with ribosomal 30S-5SRNP particles and 40S subunits of rat liver. J Biochem. 1998;123:294-304 pubmed
    ..These results imply the participation of the intrinsic ATPase of 30S-5SRNP particles and 40S subunits in polypeptide elongation, and the important role of the 5SRNP moiety of 30S-5SRNP particles in the ATPase activity. ..
  35. Klein P, Cirioni O, Giacometti A, Scalise G. In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum. J Antimicrob Chemother. 2008;62:1101-4 pubmed publisher
    The aim of this study was to assess the effect of commercial aurintricarboxylic acid (ATA) against Cryptosporidium parvum...
  36. Zhang F, Wei W, Chai H, Xie X. Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration. J Immunol. 2013;190:1017-25 pubmed publisher
    ..b>Aurintricarboxylic acid (ATA), an inhibitor of protein-nucleic acid interaction, has been reported to block with the JAK/STAT ..
  37. Bhattacharya R, Lakshmana Rao P. Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. Toxicol Lett. 2001;119:59-70 pubmed
    ..5-3 h) of various pharmacological agents viz., Trolox (antioxidant), EGTA (Ca2+ modulator) and aurintricarboxylic acid (ATA; Ca2+/Mg2+ dependent endonuclease inhibitor)...
  38. Rozalski M, Boncler M, Golanski J, Watala C. Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic acid on platelet activation and degranulation. Biochem Pharmacol. 2001;62:1399-408 pubmed
    ..complex (GPIIb-IIIa)] inhibits activation and degranulation of human platelets, and opposes the action of aurintricarboxylic acid (ATA), the antagonist of von Willebrand factor, which augments platelet secretion...
  39. Udata C, Patel J, Pal D, Hejchman E, Cushman M, Mitra A. Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. Int J Pharm. 2003;250:157-68 pubmed
    ..Among the enhancers tested, 10 mM sodium desoxycholate and HP-beta-CD appear to be viable candidates for further development of an oral formulation of cosalane and its congeners. ..
  40. Sakai A, Saito C, Inada N, Kuroiwa T. Transcriptional activities of the chloroplast-nuclei and proplastid-nuclei isolated from tobacco exhibit different sensitivities to tagetitoxin: implication of the presence of distinct RNA polymerases. Plant Cell Physiol. 1998;39:928-34 pubmed
  41. Zhao Z, Morris C, Budde J, Wang N, Muraki S, Sun H, et al. Inhibition of myocardial apoptosis reduces infarct size and improves regional contractile dysfunction during reperfusion. Cardiovasc Res. 2003;59:132-42 pubmed
    ..In the present study, we examined whether inhibition of apoptosis with aurintricarboxylic acid (ATA), an endonuclease inhibitor, during R reduces infarct size and improves regional contractile ..
  42. Basu C, Luo H, Kausch A, Chandlee J. Transient reporter gene (GUS) expression in creeping bentgrass (Agrostis palustris) is affected by in vivo nucleolytic activity. Biotechnol Lett. 2003;25:939-44 pubmed
    ..When callus tissue was incubated for 24 h with heparin, spermidine, aurintricarboxylic acid or polyethylene glycol, only heparin and spermidine were effective as in vitro nuclease inhibitors, ..
  43. Suram A, Hegde M, Rao K. A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease. Arch Biochem Biophys. 2007;463:245-52 pubmed
    ..The nuclease specific inhibitor aurintricarboxylic acid prevented the DNA nicking property of Abeta...
  44. Mohamed T, Abou Leisa R, Baudoin F, Stafford N, Neyses L, Cartwright E, et al. Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes. J Mol Cell Cardiol. 2013;63:57-68 pubmed publisher
    ..In addition, similar approaches could be useful for studying the activity of other calcium transporters during excitation-contraction coupling in the heart. ..
  45. McConkey D, Chow S, Orrenius S, Jondal M. NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target. FASEB J. 1990;4:2661-4 pubmed
    ..The endonuclease inhibitor, aurintricarboxylic acid, inhibited both DNA fragmentation and killing without influencing the Ca2+ increase in target cells...
  46. Shadrick W, Mukherjee S, Hanson A, Sweeney N, Frick D. Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP. Biochemistry. 2013;52:6151-9 pubmed publisher
    b>Aurintricarboxylic acid (ATA) is a potent inhibitor of many enzymes needed for cell and virus replication, such as polymerases, helicases, nucleases, and topoisomerases...
  47. Lim D, Park Y, Kim S, Kim Y, Park C, Kim S, et al. Aurintricarboxylic acid promotes the conversion of naive CD4+CD25- T cells into Foxp3-expressing regulatory T cells. Int Immunol. 2011;23:583-92 pubmed publisher
    ..Among the several anti-apoptotic agents tested, aurintricarboxylic acid (ATA) was found to induce the in vitro conversion of naive CD4(+) T cells into Foxp3(+) Treg cells with ..
  48. Bardhan M, Chowdhury J, Ganguly T. Investigations on the interactions of aurintricarboxylic acid with bovine serum albumin: Steady state/time resolved spectroscopic and docking studies. J Photochem Photobiol B. 2011;102:11-9 pubmed publisher
    In this paper, the nature of the interactions between bovine serum albumin (BSA) and aurintricarboxylic acid (ATA) has been investigated by measuring steady state and time-resolved fluorescence, circular dichroism (CD), FT-IR and ..
  49. Fong K, Smith T. Citrate-mediated release of aurintricarboxylic acid from a calcium alginate complex: implications for intravaginal HIV chemoprophylaxis and related applications. Pharm Dev Technol. 2009;14:341-2 pubmed publisher
    ..These results suggest that seminal and prostatic fluid can be considered in the design of an intravaginal system for HIV chemoprophylaxis. ..
  50. Pattingre S, Bauvy C, Codogno P. Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem. 2003;278:16667-74 pubmed
    ..and Codogno, P. (2000) J. Biol. Chem. 275, 39090-39095). Here we show that ERK1/2 activation by aurintricarboxylic acid (ATA) treatment induces the phosphorylation of GAIP in an amino acid-dependent manner...
  51. Foresti R, Hoque M, Monti D, Green C, Motterlini R. Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. J Pharmacol Exp Ther. 2005;312:686-93 pubmed
    ..Thus, this study identified novel plant constituents that highly induce HO-1 in endothelial cells and investigated some of the mechanisms involved in this effect. ..
  52. Sagi O, Wolfson M, Utko N, Muradian K, Fraifeld V. p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid. Mech Ageing Dev. 2005;126:249-54 pubmed
    ..Also, we suggested that the level of p66ShcA could be modulated by a putative longevity-promoting agent aurintricarboxylic acid [aurintricarboxylic acid (ATA); Fraifeld, V., Wolfson, M., Sagi, O., Seidman, R., Asraf, H., Utko, N...
  53. Yoo J, Medina Franco J. Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies. J Mol Model. 2012;18:1583-9 pubmed publisher
    ..Trimethylaurintricarboxylic acid can be a valuable biochemical tool to study DNMT1 inhibition in cancer and other diseases related to DNA methylation. ..