chlorogenic acid

Summary

Summary: A naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68).

Top Publications

  1. Liu Y, Zhou C, Qiu C, Lu X, Wang Y. Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL?60 cells. Mol Med Rep. 2013;8:1106-10 pubmed publisher
    b>Chlorogenic acid (CA), is found in high abundance in the leaves of a number of plants and has antibacterial, antiphlogistic, antimutagenic, antioxidant and other biological activities...
  2. Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, et al. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology. 2013;303:107-14 pubmed publisher
    b>Chlorogenic acid (CGA) is a type of polyphenol with anti-inflammatory, antioxidant activities. Our previous studies showed CGA could efficiently inhibit carbon tetrachloride (CCl(4))-induced liver fibrosis in rats...
  3. Mubarak A, Bondonno C, Liu A, Considine M, Rich L, Mas E, et al. Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. J Agric Food Chem. 2012;60:9130-6 pubmed publisher
    ..Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric ..
  4. Mills C, Oruna Concha M, Mottram D, Gibson G, Spencer J. The effect of processing on chlorogenic acid content of commercially available coffee. Food Chem. 2013;141:3335-40 pubmed publisher
    ..These results highlight the broad range of CGA quantity in commercial coffee and demonstrate that coffee choice is important in delivering optimum CGA intake to consumers. ..
  5. Shen W, Qi R, Zhang J, Wang Z, Wang H, Hu C, et al. Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons. Brain Res Bull. 2012;88:487-94 pubmed publisher
    ..As a natural phenolic acid, chlorogenic acid (CGA) has been shown to have anti-inflammatory properties...
  6. Chao J, Wang H, Zhao W, Zhang M, Zhang L. Investigation of the inclusion behavior of chlorogenic acid with hydroxypropyl-?-cyclodextrin. Int J Biol Macromol. 2012;50:277-82 pubmed publisher
    The inclusion complexation behavior of chlorogenic acid (CGA) with the hydroxypropyl-?-cyclodextrin (HP-?-CD) was investigated in both solution and the solid state by UV-vis and fluorescence spectroscopy, infrared spectroscopy (IR), NMR ..
  7. Shi H, Dong L, Dang X, Liu Y, Jiang J, Wang Y, et al. Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells. Inflamm Res. 2013;62:581-7 pubmed publisher
    This study was aimed at investigating the effect of chlorogenic acid (CGA) on lipopolysaccharide (LPS)-induced proinflammatory signaling in hepatic stellate cells (HSCs)...
  8. Hunyadi A, Martins A, Hsieh T, Seres A, Zupko I. Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats. PLoS ONE. 2012;7:e50619 pubmed publisher
    ..activity of an extract of mulberry leaves (MA), and to examine to what extent three major constituents, chlorogenic acid, rutin and isoquercitrin, might contribute to the observed activity...
  9. Lou Z, Wang H, Zhu S, Ma C, Wang Z. Antibacterial activity and mechanism of action of chlorogenic acid. J Food Sci. 2011;76:M398-403 pubmed publisher
    In this study, the antibacterial activity and mechanism of action of chlorogenic acid against bacteria were assessed...

More Information

Publications62

  1. Kwon S, Lee H, Kim J, Hong S, Kim H, Jo T, et al. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol. 2010;649:210-7 pubmed publisher
    b>Chlorogenic acid is a major polyphenolic component of many plants and beverages, and is particularly abundant in coffee...
  2. Li S, Bian H, Liu Z, Wang Y, Dai J, He W, et al. Chlorogenic acid protects MSCs against oxidative stress by altering FOXO family genes and activating intrinsic pathway. Eur J Pharmacol. 2012;674:65-72 pubmed publisher
    b>Chlorogenic acid as an antioxidant exists widely in edible and medicinal plants, and can protect cell against apoptosis induced by oxidative stress. However, its molecular mechanisms remain largely unknown...
  3. Xu J, Hu Q, Liu Y. Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem. 2012;60:11625-30 pubmed publisher
    b>Chlorogenic acid is a well-known antioxidant and has more isomers according to the difference in binding location and number of caffeic on quinic acid...
  4. Rodriguez Mateos A, Cifuentes Gomez T, Tabatabaee S, Lecras C, Spencer J. Procyanidin, anthocyanin, and chlorogenic acid contents of highbush and lowbush blueberries. J Agric Food Chem. 2012;60:5772-8 pubmed publisher
    ..were analyzed for their anthocyanin, flavanol oligomer, and chlorogenic acid contents...
  5. Boettler U, Volz N, Pahlke G, Teller N, Kotyczka C, Somoza V, et al. Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Mol Nutr Food Res. 2011;55:798-802 pubmed publisher
    ..Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo. ..
  6. Tsuda S, Egawa T, Ma X, Oshima R, Kurogi E, Hayashi T. Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle. J Nutr Biochem. 2012;23:1403-9 pubmed publisher
    b>Chlorogenic acid is an ester of caffeic and quinic acids, and is one of the most widely consumed polyphenols because it is abundant in foods, especially coffee...
  7. Hebeda C, Bolonheis S, Nakasato A, Belinati K, Souza P, Gouvea D, et al. Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus. J Ethnopharmacol. 2011;135:261-9 pubmed publisher
    Species of Lychnophora are used in Brazilian folk medicine as analgesic and anti-inflammatory agents. Chlorogenic acid (CGA) and their analogues are important components of polar extracts of these species, as well in several European and ..
  8. Kitagawa S, Yoshii K, Morita S, Teraoka R. Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage. Chem Pharm Bull (Tokyo). 2011;59:793-6 pubmed
    We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin...
  9. Kim Y, Kim N, Lee Y, Kim J. Preventive effect of chlorogenic acid on lens opacity and cytotoxicity in human lens epithelial cells. Biol Pharm Bull. 2011;34:925-8 pubmed
    The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts...
  10. Mennella G, Lo Scalzo R, Fibiani M, D Alessandro A, Francese G, Toppino L, et al. Chemical and bioactive quality traits during fruit ripening in eggplant (S. melongena L.) and allied species. J Agric Food Chem. 2012;60:11821-31 pubmed publisher
    ..revealed a higher sugar content and low PPO activity in NAS- compared to D3R-typologies, whereas higher chlorogenic acid and anthocyanin contents were present in D3R-typologies...
  11. Francisco V, Costa G, Figueirinha A, Marques C, Pereira P, Miguel Neves B, et al. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-?B pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol. 2013;148:126-34 pubmed publisher
    ..Cymbopogon citratus (DC.) Stapf leaves infusion is used in traditional medicine for the treatment of inflammatory conditions, however little is known about their bioactive compounds...
  12. Kim J, Lee S, Shim J, Kim H, Kim J, Jang Y, et al. Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H?O?-induced apoptosis in primary cortical neurons. Neurochem Int. 2012;60:466-74 pubmed publisher
    ..the protective effects of caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid (5-O-caffeoylquinic acid), which is present in both caffeinated and decaffeinated coffee, against oxidative ..
  13. Kim C, Kim J, Lee Y, Sohn E, Jo K, Kim J. Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats. Arch Pharm Res. 2011;34:847-52 pubmed publisher
    b>Chlorogenic acid (5-O-caffeoylquinic acid, CA), a phenolic compound found ubiquitously in plants, has antidiabetic effect in diabetic animal models. In this study, we investigated the inhibitory effect of CA on diabetic cataractogenesis...
  14. Crozier T, Stalmach A, Lean M, Crozier A. Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct. 2012;3:30-3 pubmed publisher
    ..New data are needed to provide informative labelling, with attention to bean variety, preparation, and barista methods. ..
  15. Yun N, Kang J, Lee S. Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. J Nutr Biochem. 2012;23:1249-55 pubmed publisher
    ..b>Chlorogenic acid (CGA), one of the most abundant polyphenols in the human diet, has been shown to exert potent anti-..
  16. Ong K, Hsu A, Tan B. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLoS ONE. 2012;7:e32718 pubmed publisher
    b>Chlorogenic acid (CGA) has been shown to delay intestinal glucose absorption and inhibit gluconeogenesis...
  17. Atanasova Penichon V, Pons S, Pinson Gadais L, Picot A, Marchegay G, Bonnin Verdal M, et al. Chlorogenic acid and maize ear rot resistance: a dynamic study investigating Fusarium graminearum development, deoxynivalenol production, and phenolic acid accumulation. Mol Plant Microbe Interact. 2012;25:1605-16 pubmed publisher
    ..We found that chlorogenic acid is more abundant in the moderately resistant variety, with levels spiking in the earliest kernel stages ..
  18. Ong K, Hsu A, Tan B. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol. 2013;85:1341-51 pubmed publisher
    b>Chlorogenic acid (CGA) has been shown to stimulate glucose uptake in skeletal muscle through the activation of AMPK...
  19. Li X, Liu Y, Hou X, Peng H, Zhang L, Jiang Q, et al. Chlorogenic acid inhibits the replication and viability of enterovirus 71 in vitro. PLoS ONE. 2013;8:e76007 pubmed publisher
    ..Furthermore, CHA inhibited secretions of IL-6, TNF-?, IFN-? and MCP-1 in EV71-infected RD cells. Altogether, these results revealed that CHA may have antiviral properties for treating EV71 infection. ..
  20. Wan C, Wong C, Pin W, Wong M, Kwok C, Chan R, et al. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-? in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother Res. 2013;27:545-51 pubmed publisher
    ..In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high-density ..
  21. Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm. 2011;403:136-8 pubmed publisher
    ..Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid...
  22. Zhang L, Chang C, Liu Y, Chen Z. [Effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011;33:281-6 pubmed publisher
    To explore the effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism...
  23. Oku H, Ogawa Y, Iwaoka E, Ishiguro K. Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol Pharm Bull. 2011;34:1330-3 pubmed
    ..Bioassay-guided fractionation of the 35% EtOH extract led to isolation of chlorogenic acid (1) and three known iridoid derivatives, loganin (2), secoxyloganin (3) and sweroside (4), all of which ..
  24. Laguerre M, Chen B, Lecomte J, Villeneuve P, McClements D, Decker E. Antioxidant properties of chlorogenic acid and its alkyl esters in stripped corn oil in combination with phospholipids and/or water. J Agric Food Chem. 2011;59:10361-6 pubmed publisher
    ..b>Chlorogenic acid and its butyl, dodecyl, and hexadecyl esters were used as model phenolic antioxidants with various ..
  25. Tunnicliffe J, Eller L, Reimer R, Hittel D, Shearer J. Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats. Appl Physiol Nutr Metab. 2011;36:650-9 pubmed publisher
    ..Given the widespread consumption and availability of coffee, CGA may be a viable prevention tool for T2D. ..
  26. Wang Z, Wang D, Yu Y, Sui Y, Cui H, Zhang M. [Study on allergenicity of chlorogenic acid in Qingkailing injection]. Zhongguo Zhong Yao Za Zhi. 2011;36:1870-3 pubmed
    To observe the allergenicity of chlorogenic acid (CA) in Qingkailing injection...
  27. Ji L, Jiang P, Lu B, Sheng Y, Wang X, Wang Z. Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. J Nutr Biochem. 2013;24:1911-9 pubmed publisher
    b>Chlorogenic acid (CGA) is one of the most abundant dietary polyphenols, possessing well-known antioxidant capacity...
  28. Burgos Morón E, Calderón Montaño J, Orta M, Pastor N, Pérez Guerrero C, Austin C, et al. The coffee constituent chlorogenic acid induces cellular DNA damage and formation of topoisomerase I- and II-DNA complexes in cells. J Agric Food Chem. 2012;60:7384-91 pubmed publisher
    b>Chlorogenic acid (CGA) is a plant polyphenol with known antioxidant properties...
  29. Shin J, Sohn J, Park K. Chlorogenic acid decreases retinal vascular hyperpermeability in diabetic rat model. J Korean Med Sci. 2013;28:608-13 pubmed publisher
    To evaluate the effect of chlorogenic acid (CGA), a polyphenol abundant in coffee, on retinal vascular leakage in the rat model of diabetic retinopathy, Sprague-Dawley rats were divided into four groups: controls, streptozotocin-induced ..
  30. Escamilla Trevino L, Shen H, Hernandez T, Yin Y, Xu Y, Dixon R. Early lignin pathway enzymes and routes to chlorogenic acid in switchgrass (Panicum virgatum L.). Plant Mol Biol. 2014;84:565-76 pubmed publisher
    ..b>Chlorogenic acid (CGA, caffeoyl quinate) is the major soluble phenolic compound in switchgrass, and the lignin and CGA ..
  31. Li X, Wang R, Shen Y, Meng Z, Chen J, Yang J, et al. [Simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigeron breviscapus by high-performance liquid chromatography]. Zhongguo Zhong Yao Za Zhi. 2013;38:2237-40 pubmed
    A high-performance liquid chromatographic (HPLC) method was developed for simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigerontis Herba...
  32. Wu X, Yang H, Lin D, Zhang J, Luo F, Xu X. [Comprehensive research and evaluation of chlorogenic acid allergy]. Zhongguo Zhong Yao Za Zhi. 2010;35:3357-61 pubmed
    The non-allergy of chlorogenic acid was demonstrated by the study result of allergy with different purity of chlorogenic acid and comprehensive analysis of literature...
  33. Rakshit S, Mandal L, Pal B, Bagchi J, Biswas N, Chaudhuri J, et al. Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Biochem Pharmacol. 2010;80:1662-75 pubmed publisher
    b>Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via ..
  34. Santos W, Santhiago M, Yoshida I, Kubota L. Novel electrochemical sensor for the selective recognition of chlorogenic acid. Anal Chim Acta. 2011;695:44-50 pubmed publisher
    ..a novel sensitive molecularly imprinted electrochemical sensor was constructed for the selective detection of chlorogenic acid (CGA) by deposition of a molecularly imprinted siloxane (MIS) film, prepared by sol-gel process, onto Au bare ..
  35. Lee K, Lee J, Jang H, Kim S, Chang M, Park S, et al. Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. Eur J Pharmacol. 2012;689:89-95 pubmed publisher
    b>Chlorogenic acid (CGA) has been reported to have various beneficial effects on the cardiovascular and central nervous systems...
  36. Mullen W, Nemzer B, Ou B, Stalmach A, Hunter J, Clifford M, et al. The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. J Agric Food Chem. 2011;59:3754-62 pubmed publisher
    ..Antioxidant activity in whole coffee fruit extracts was up to 25-fold higher than in powders dependent upon the radical. Total antioxidant activity of samples displayed strong correlation to CGA content. ..
  37. Dong J, Wang Y, Wang S, Yin L, Xu G, Zheng C, et al. Selenium increases chlorogenic acid, chlorophyll and carotenoids of Lycium chinense leaves. J Sci Food Agric. 2013;93:310-5 pubmed publisher
    ..Selenium has been reported to increase some components of plants. In this study, the composition of polyphenols of L. chinense leaves were analysed, and the effects of selenium on the polyphenols and other components were studied...
  38. Kim C, Yu H, Sohn J. The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization. Korean J Ophthalmol. 2010;24:163-8 pubmed publisher
    To evaluate the inhibitory effect of chlorogenic acid on laser-induced choroidal neovascularization (CNV) in a rat model...
  39. Park H, Davis S, Liang H, Rosenberg D, Bruno R. Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice. Nutr Cancer. 2010;62:362-70 pubmed publisher
    ..data have suggested that coffee consumption is inversely related to CRC risk, which may be attributed to chlorogenic acid (CGA), an ester of caffeic acid (CA) and quinic acid...
  40. van Dijk A, Olthof M, Meeuse J, Seebus E, Heine R, van Dam R. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009;32:1023-5 pubmed publisher
    ..We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance...
  41. Guo B, Zhang Z, Butron A, Widstrom N, Snook M, Lynch R, et al. Lost P1 allele in sh2 sweet corn: quantitative effects of p1 and a1 genes on concentrations of maysin, apimaysin, methoxymaysin, and chlorogenic acid in maize silk. J Econ Entomol. 2004;97:2117-26 pubmed
    ..In a study of quantitative genetic control over silk maysin, AM-maysin (apimaysin and methoxymaysin), and chlorogenic acid contents in an F2 population derived from GE37 (dent corn, P1A1) and 565 (sh2 sweet corn, p1a1), we ..
  42. Clifford M, Knight S, Surucu B, Kuhnert N. Characterization by LC-MS(n) of four new classes of chlorogenic acids in green coffee beans: dimethoxycinnamoylquinic acids, diferuloylquinic acids, caffeoyl-dimethoxycinnamoylquinic acids, and feruloyl-dimethoxycinnamoylquinic acids. J Agric Food Chem. 2006;54:1957-69 pubmed
    ..The mass spectrometric resolution of six isomeric chlorogenic acids (Mr 544) in a crude plant extract by fragment-targeted LC-MS2 and LC-MS3 experiments illustrates the analytical power and advantage of ion trap mass spectroscopy. ..
  43. Herling A, Burger H, Schubert G, Hemmerle H, Schaefer H, Kramer W. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur J Pharmacol. 1999;386:75-82 pubmed
    ..5-b]pyridin-1-yl-3-phenyl-acryloyloxy)-cyclohexanecarboxylic acid), a derivative of chlorogenic acid, specifically inhibits the glucose-6-phosphate translocating component T1 of the glucose-6-phosphatase system...
  44. Johnston K, Clifford M, Morgan L. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003;78:728-33 pubmed
    ..5 mmol chlorogenic acid/L). Blood samples were taken frequently over the following 3 h...
  45. Bandyopadhyay G, Biswas T, Roy K, Mandal S, Mandal C, Pal B, et al. Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood. 2004;104:2514-22 pubmed
    We report that chlorogenic acid (Chl) induces apoptosis of several Bcr-Abl-positive chronic myelogenous leukemia (CML) cell lines and primary cells from CML patients in vitro and destroys Bcr-Abl-positive K562 cells in vivo...
  46. McCarty M. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Med Hypotheses. 2005;64:848-53 pubmed
    ..production of the incretin hormone glucagon-like peptide-1 (GLP-1), possibly owing to an inhibitory effect of chlorogenic acid (CGA -- the chief polyphenol in coffee) on glucose absorption...
  47. Tamura H, Akioka T, Ueno K, Chujyo T, Okazaki K, King P, et al. Anti-human immunodeficiency virus activity of 3,4,5-tricaffeoylquinic acid in cultured cells of lettuce leaves. Mol Nutr Food Res. 2006;50:396-400 pubmed
    ..The intact plant produced chicoric acid (dicaffeoyl tartaric acid: L-CCA) as well as chlorogenic acid (3-caffeoylquinic acid: 3-CQA) as the major metabolites...
  48. Suzuki A, Yamamoto N, Jokura H, Yamamoto M, Fujii A, Tokimitsu I, et al. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens. 2006;24:1065-73 pubmed
    ..We therefore examined the effects of 5-caffeoylquinic acid (CQA), a representative chlorogenic acid, on blood pressure and vascular function in age-matched normotensive Wistar-Kyoto rats and spontaneously ..
  49. Reddivari L, Hale A, Miller J. Genotype, location, and year influence antioxidant activity, carotenoid content, phenolic content, and composition in specialty potatoes. J Agric Food Chem. 2007;55:8073-9 pubmed
    ..Phenolic composition differed significantly among genotypes and between locations. The AOA, TP, and chlorogenic acid content were significantly correlated with one another...
  50. Legrand D, Scheen A. [Does coffee protect against type 2 diabetes?]. Rev Med Liege. 2007;62:554-9 pubmed
    ..attributed exclusively to caffeine, but rather that it should be explained by other components, most probably chlorogenic acid and/or various anti-oxidants...
  51. Olthof M, Hollman P, Buijsman M, Van Amelsvoort J, Katan M. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr. 2003;133:1806-14 pubmed
    ..The aim of this study was to identify and quantify the phenolic acid metabolites of chlorogenic acid (major phenol in coffee), quercetin-3-rutinoside (major flavonol in tea) and black tea phenols in humans, and ..
  52. Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J Agric Food Chem. 2000;48:5496-500 pubmed
    Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites...
  53. Liu Z, Liu Z, Shi Y, Zhou G. Evaluation of the immunosensitizing potential of chlorogenic acid using a popliteal lymph node assay in BALB/c mice. Food Chem Toxicol. 2010;48:1059-65 pubmed publisher
    It has yet to be established whether chlorogenic acid (CGA), a common xenobiotic with potential exposure risk to humans, is associated with immune-mediated hypersensitivity reactions (HRs)...