nitrosomethylurethane

Summary

Summary: An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.

Top Publications

  1. Harris J, Jackson F, Moxley M, Longmore W. Effect of exogenous surfactant instillation on experimental acute lung injury. J Appl Physiol (1985). 1989;66:1846-51 pubmed
  2. Anderson B, Jackson F, Moxley M, Longmore W. Effects on experimental acute lung injury 24 hours after exogenous surfactant instillation. Exp Lung Res. 1992;18:191-204 pubmed
    ..0 +/- 0.5 dyn/cm after mixing). Intratracheal Survanta shows a beneficial effect on physiologic parameters and biochemical and functional characteristics of alveolar surfactant for 24 h in rats with NNNMU-induced acute lung injury...
  3. Furihata C, Ikui E, Matsushima T. DNA single-strand scission in the pyloric mucosa of rat stomach induced by four glandular stomach carcinogens and three other chemicals. Mutat Res. 1996;368:1-6 pubmed
    ..The present results together with previous information suggest that DNA single-strand scission is a good marker for tumor-initiating activity in rat stomach mucosa...
  4. Yasuhara K, Mitsumori K, Yoshimura H, Imazawa T, Hayashi S, Onodera H, et al. Relationship between the development of pulmonary fibrosis and lung tumors in Syrian golden hamsters induced by N-methyl-N-nitrosourethane. Toxicol Pathol. 1995;23:551-9 pubmed
  5. Nukata Y, Shiiba K, Ebine N, Ishii S, Matsuno S. [Oral administration of OK-432 is an effective immunotherapy against colon cancer--a study in a murine mesenteric lymphnode metastasis model]. Nihon Geka Gakkai Zasshi. 1995;96:671-9 pubmed
    ..In conclusion, oral administration of OK-432 appears to be an effective immunotherapy against colonic cancer especially in the prevention and the treatment for MLN metastasis...
  6. Weinkam R, Plakunov I. A kinetic model of the cell culture cytotoxicity of metabolically activated agents: N-methyl-N-(acetoxymethyl)nitrosamine, methylnitrosourethane, and (methylazoxy)methanol acetate. Chem Res Toxicol. 1989;2:288-94 pubmed
    ..This observation is consistent with a growth rate inhibition effect of the methyldiazonium ion that reflects the intrinsic activity of this species that is independent of the precursor molecule.(ABSTRACT TRUNCATED AT 250 WORDS)..
  7. Maekawa A, Onodera H, Matsushima Y, Nagaoka T, Todate A, Shibutani M, et al. Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitrosourethane. Jpn J Cancer Res. 1989;80:632-6 pubmed
    ..365 x 10(-2), 0.110 x 10(-1) and 0.779 x 10(-1) ppm, respectively. The VSDs estimated in the present study are discussed in comparison with those of other carcinogens...
  8. Fok T, Gu G, To K, Xu F, Ng P, Yin J. Oxygen consumption by lungs with acute and chronic injury in a rabbit model. Intensive Care Med. 2001;27:1532-8 pubmed
    ..To study the oxygen consumption by lungs with acquired acute and chronic injury in a rabbit model...
  9. Cruz W, Corbett J, Longmore W, Moxley M. Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats. Am J Physiol. 1999;276:L263-8 pubmed
    ..These findings suggest that the pathogenic mechanism by which NNMU induces acute lung injury involves BAL cell stimulation of iNOS expression and. NO production in lung tissue...

More Information

Publications35

  1. Lewis J, Ikegami M, Higuchi R, Jobe A, Absolom D. Nebulized vs. instilled exogenous surfactant in an adult lung injury model. J Appl Physiol (1985). 1991;71:1270-6 pubmed
    ..Surfactant administered as an aerosol resulted in modest physiological improvements in this model of lung injury and was superior to the tracheal instillation technique...
  2. Lewis J, Ikegami M, Jobe A. Metabolism of exogenously administered surfactant in the acutely injured lungs of adult rabbits. Am Rev Respir Dis. 1992;145:19-23 pubmed
    ..This indicates that the alveolar environment influenced the function of the exogenously administered surfactant differently in normal and injured rabbits.(ABSTRACT TRUNCATED AT 250 WORDS)..
  3. Ikegami M, Korfhagen T, Whitsett J, Bruno M, Wert S, Wada K, et al. Characteristics of surfactant from SP-A-deficient mice. Am J Physiol. 1998;275:L247-54 pubmed
    ..Although the absence of SP-A changed the structure and in vitro properties of surfactant, the in vivo function of surfactant in SP-A(-/-) mice was not changed under the conditions of these experiments...
  4. Puligandla P, Gill T, McCaig L, Yao L, Veldhuizen R, Possmayer F, et al. Alveolar environment influences the metabolic and biophysical properties of exogenous surfactants. J Appl Physiol (1985). 2000;88:1061-71 pubmed
    ..Thus further preclinical studies are warranted to investigate the specific factors within the alveolar environment that lead to the differences observed in this study...
  5. Kaneko M, Morimura K, Nishikawa T, Wanibuchi H, Takada N, Osugi H, et al. Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis. 2002;23:1729-35 pubmed
    ..The present study demonstrates that rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens have different underlying genetic alterations, even if their pathological features are similar...
  6. Cruz W, Moxley M, Corbett J, Longmore W. Inhibition of nitric oxide synthase attenuates NNMU-induced alveolar injury in vivo. Am J Physiol. 1997;273:L1167-73 pubmed
    ..These investigations demonstrate that the inhibition of NOS attenuates NNMU-induced acute lung injury, suggesting a role for NO. in the progression of acute respiratory distress syndrome...
  7. Wichmann A, Thomson N, Peterson L, Wattenberg E. Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells. Chem Res Toxicol. 2003;16:87-94 pubmed
    ..Altogether, these data indicate that genotoxic methylating agents activate MAPKs through mechanisms that are likely to involve the alkylation of cellular targets other than DNA...
  8. Ito Y, Veldhuizen R, Yao L, McCaig L, Bartlett A, Lewis J. Ventilation strategies affect surfactant aggregate conversion in acute lung injury. Am J Respir Crit Care Med. 1997;155:493-9 pubmed
    ..We conclude that increased surfactant aggregate conversion resulting from suboptimal ventilation of injured lungs may play an important role in the pathophysiology of ventilation-induced lung dysfunction in acute lung injury...
  9. Kappler R, Schlegel J, Kindler Röhrborn A, Mennel H, Scherthan H. Comparative genomic in situ hybridization discloses recurrent gain of chromosome 4 in experimental gliomas of the rat. Cytogenet Cell Genet. 1999;84:194-8 pubmed
    ..Therefore, we conclude that these two alterations may represent different pathways in the pathogenesis of experimental gliomas in the rat. Findings are discussed in analogy to human gliomas...
  10. Yasuhara K, Mitsumori K, Imazawa T, Yoshimura H, Onodera H, Takegawa K, et al. Ultrastructure and cell proliferative activities of karyomegalic alveolar epithelial cells in early pulmonary inflammatory lesions of Syrian golden hamsters induced by N-methyl-N-nitrosourethane. J Vet Med Sci. 1996;58:825-31 pubmed
  11. Pappert D, Gilliard N, Heldt G, Merritt T, Wagner P, Spragg R. Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits. Intensive Care Med. 1996;22:345-52 pubmed
    ..To define the effect of N-nitroso-N-methyl-urethane (NNNMU) on pulmonary gas exchange, compliance and the biochemical and functional properties of the lung surfactant system...
  12. Fitzgerald D, Piccoli C, Yamasaki H. Detection of non-genotoxic carcinogens in the BALB/c 3T3 cell transformation/mutation assay system. Mutagenesis. 1989;4:286-91 pubmed
    ..These results add to existing data supporting the validity of the BALB/c 3T3 cell transformation system as a reliable short-term in vitro test for carcinogens in general, and for non-genotoxic carcinogens in particular...
  13. Lewis J, Ikegami M, Jobe A. Altered surfactant function and metabolism in rabbits with acute lung injury. J Appl Physiol (1985). 1990;69:2303-10 pubmed
    ..These studies characterize quantitative, qualitative, and functional changes of alveolar wash surfactant subfractions in NNNMU-injured lungs...
  14. Vidal Vanaclocha F, Glaves D, Barbera Guillem E, Weiss L. Quantitative microscopy of mouse colon 26 cells growing in different metastatic sites. Br J Cancer. 1991;63:748-52 pubmed
    ..The differences between liver and lung metastases are in accord with analogous site-associated differences in metastatic patterns produced by colon carcinoma cells in mice and in humans...
  15. Peterson L, Urban A, Vu C, Cummings M, Brown L, Warmka J, et al. Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chem Res Toxicol. 2013;26:1464-73 pubmed publisher
    ..N-Nitrosomethylurethane (NMUr), acetoxymethylmethylnitrosamine (AMMN), and 4-(methylnitrosamino)-4-acetoxy-1-(3-pyridyl)-1-..
  16. Tamura T, Nishi T, Goto T, Takeshima H, Ushio Y, Sakata T. Combination of IL-12 and IL-18 of electro-gene therapy synergistically inhibits tumor growth. Anticancer Res. 2003;23:1173-9 pubmed
  17. Dive V, Andarawewa K, Boulay A, Matziari M, Beau F, Guerin E, et al. Dosing and scheduling influence the antitumor efficacy of a phosphinic peptide inhibitor of matrix metalloproteinases. Int J Cancer. 2005;113:775-81 pubmed
  18. Homberg J, Olivier J, Smits B, Mul J, Mudde J, Verheul M, et al. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience. 2007;146:1662-76 pubmed
  19. Veldhuizen R, Marcou J, Yao L, McCaig L, Ito Y, Lewis J. Alveolar surfactant aggregate conversion in ventilated normal and injured rabbits. Am J Physiol. 1996;270:L152-8 pubmed
    ..Furthermore, increased aggregate conversion in injured lungs might contribute to increased small-to-large aggregate ratios in these lungs compared with normal lungs...
  20. Mitsumori K, Yasuhara K, Mori I, Hayashi S, Shimo T, Onodera H, et al. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett. 1998;129:181-90 pubmed
    ..The present study confirmed that rasH2 mice are very sensitive to lung tumor induction by UR and suggested that alveolar epithelial cells in the reparative stage during pulmonary fibrosis are resistant to DNA damage by this carcinogen...
  21. Mizoguchi Y, Hirose M, Yamaguchi T, Boonyaphiphat P, Miki T, Shirai T. Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane. Jpn J Cancer Res. 1998;89:475-80 pubmed
    ..The results indicate that HTHQ may have very weak or weak promotion potential for tongue and forestomach carcinogenesis, but that both minimum and maximum thresholds for active dose levels may exist...
  22. Veldhuizen R, Ito Y, Marcou J, Yao L, McCaig L, Lewis J. Effects of lung injury on pulmonary surfactant aggregate conversion in vivo and in vitro. Am J Physiol. 1997;272:L872-8 pubmed
    ..Furthermore, in vitro conversion of isolated LA does not necessarily reflect the conversion of aggregates within the alveoli...
  23. Ueda T, Ikegami M. Change in properties of exogenous surfactant in injured rabbit lung. Am J Respir Crit Care Med. 1996;153:1844-9 pubmed
    ..These changes probably result from the association of endogenous surfactant components with exogenous surfactant...
  24. Mitsumori K, Yasuhara K, Yoshimura H, Uneyama C, Imazawa T, Onodera H, et al. Experimental induction of pulmonary fibrosis in Syrian golden hamsters by N-methyl-N-nitrosourethane. Exp Toxicol Pathol. 1994;46:287-95 pubmed
  25. Lunn G, Sansone E. Dealing with spills of hazardous chemicals: some nitrosamides. Food Chem Toxicol. 1988;26:481-4 pubmed
    ..In all cases the nitrosamides are completely destroyed and only non-mutagenic reaction mixtures are produced...
  26. Higuchi R, Lewis J, Ikegami M. In vitro conversion of surfactant subtypes is altered in alveolar surfactant isolated from injured lungs. Am Rev Respir Dis. 1992;145:1416-20 pubmed
    ..Furthermore, SP-A may play an important role in the metabolism of alveolar surfactant both in normal and in injured lungs...