zineb

Summary

Summary: An agricultural fungicide of the dithiocarbamate class. It has relatively low toxicity and there is little evidence of human injury from exposure.

Top Publications

  1. Shukla Y, Arora A. Transplacental carcinogenic potential of the carbamate fungicide mancozeb. J Environ Pathol Toxicol Oncol. 2001;20:127-31 pubmed
  2. Soloneski S, Reigosa M, Larramendy M. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. II. micronucleus induction in immunophenotyped human lymphocytes. Environ Mol Mutagen. 2002;40:57-62 pubmed
    ..0-100.0 microg/ml of the dithiocarbamate pesticide zineb and its commercial formulation azzurro...
  3. Fejes S, Budai P, Várnagy L, Molnar T, Szabo R, Fáncsi T. Toxicity of a mancozeb containing fungicide formulation and CU-sulphate to chicken embryos after administration as single compounds or in combination. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67:105-9 pubmed
  4. Jia Z, Misra H. Exposure to mixtures of endosulfan and zineb induces apoptotic and necrotic cell death in SH-SY5Y neuroblastoma cells, in vitro. J Appl Toxicol. 2007;27:434-46 pubmed
    ..Earlier it was demonstrated that exposure to the pesticides endosulfan and zineb, alone and in combination, caused neurodegeneration in vivo...
  5. Jia Z, Misra H. Developmental exposure to pesticides zineb and/or endosulfan renders the nigrostriatal dopamine system more susceptible to these environmental chemicals later in life. Neurotoxicology. 2007;28:727-35 pubmed
    ..The purpose of this study was to test the hypothesis that exposure to pesticides such as endosulfan and/or zineb during critical periods of postnatal development could result in neuronal dysfunction and enhance the impact of ..
  6. Qin S, Qiao X, Wang X, Zhao L. [Determination of 4 dithiocarbamate residues in 22 matrices by gas chromatography]. Se Pu. 2010;28:1162-7 pubmed
    ..2 mg/kg (S/N = 10) for the 4 dithiocarbamate residues in the 22 matrices. This method is simple, fast, accurate, reproducible, and suitable for the determination of the 4 dithiocarbamate residues in the matrices mentioned in this paper...
  7. Nordby K, Andersen A, Irgens L, Kristensen P. Indicators of mancozeb exposure in relation to thyroid cancer and neural tube defects in farmers' families. Scand J Work Environ Health. 2005;31:89-96 pubmed
    ..The aim of the study was to investigate associations of indicators of mancozeb exposure with thyroid cancer and neural tube defects in farmers' families...
  8. Pauluhn J, Emura M, Mohr U, Rosenbruch M. Inhalation toxicity of propineb. Part II: Results of mechanistic studies in rats. Inhal Toxicol. 2003;15:435-60 pubmed
    ..Accordingly, the muscular deficits elicited by high concentrations of propineb are viewed to be secondary effects in an animal species likely to be more susceptible to this type of change than humans (Pauluhn & Rosenbruch, 2003)...
  9. Potocnik I, Vukojevic J, Stajic M, Rekanovic E, Milijasevic S, Stepanovic M, et al. Toxicity of fungicides with different modes of action to Cladobotryum dendroides and Agaricus bisporus. J Environ Sci Health B. 2009;44:823-7 pubmed publisher
    ..Iprodione had the best selectivity to both the pathogen and the host, although inferior than prochloraz manganese and carbendazim, fungicides officially recommended for mushroom cultivation in European Union (EU) countries...

More Information

Publications62

  1. Soloneski S, Gonzalez M, Piaggio E, Apezteguia M, Reigosa M, Larramendy M. Effect of the dithiocarbamate pesticide zineb and its commercial formulation azzurro. I. Genotoxic evaluation on cultured human lymphocytes exposed in vitro. Mutagenesis. 2001;16:487-93 pubmed
    The in vitro cytogenetic effects exerted by the dithiocarbamate fungicide zineb and one of its commercial formulations currently used in Argentina, azzurro, were studied in whole blood human lymphocyte cultures...
  2. Swarcewicz M, Gregorczyk A. The effects of pesticide mixtures on degradation of pendimethalin in soils. Environ Monit Assess. 2012;184:3077-84 pubmed publisher
  3. Tomasi T, Ashcraft J, Britzke E. Effects of fungicides on thyroid function, metabolism, and thermoregulation in cotton rats. Environ Toxicol Chem. 2001;20:1709-15 pubmed
    ..In addition, there was no difference between the treated and control animals in any of the metabolic parameters measured. It is concluded that wild rodents exposed to these compounds are not energetically compromised...
  4. Jacobsen P, Axelstad M, Boberg J, Isling L, Christiansen S, Mandrup K, et al. Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides. Reprod Toxicol. 2012;34:237-50 pubmed publisher
    ..As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture...
  5. Runkle J, Tovar Aguilar J, Economos E, Flocks J, Williams B, Muniz J, et al. Pesticide risk perception and biomarkers of exposure in Florida female farmworkers. J Occup Environ Med. 2013;55:1286-92 pubmed publisher
    ..To compare workplace characteristics, workplace behaviors, and the health beliefs of female farmworkers of childbearing age with actual biomarkers of exposure to organophosphate pesticides and to the fungicide mancozeb...
  6. Nebbia C, Dacasto M, Topi B, Burdino E, Ugazio G. Zinc ethylene-bis-dithiocarbamate (Zineb)-mediated inhibition of monooxygenases and lipid peroxidation in bovine liver microsomes. Vet Hum Toxicol. 1997;39:272-5 pubmed
    Hepatic bovine microsomes were incubated with Zineb concentrations ranging from 2.5 mM to 2.5 microM. Only the higher concentrations of the fungicide (2.5 and 0...
  7. Parihar N, Sharma B. Persistence of propineb (polymeric zinc 1,2-propylene bisdithiocarbamate) fungicide in onion and cropped soil. Bull Environ Contam Toxicol. 2011;86:545-7 pubmed publisher
    ..89 ppm of propineb (on CS(2) basis) which persisted up to the 10 and 15 days at normal 1,225 g a.i. ha(-1) and higher 2,450 g a.i. ha(-1) dose of fungicide application. The half life values of propineb ranged from 3.27 to 4.60 days...
  8. Aulakh J, Fekete A, Malik A, Mahajan R, Schmitt Kopplin P. Capillary electrophoretic-ultraviolet method for the separation and estimation of zineb, maneb, and ferbam in food samples. J AOAC Int. 2007;90:834-7 pubmed
    ..determination of ferbam [iron(III)-dimethyldithiocarbamate], maneb [manganese(II)-ethylenebisdithiocarbamate] and zineb [zinc(II)-ethylenebisdithiocarbamate], in borate buffer, after their acidic decomposition and complexation with ..
  9. Capkin E, Terzi E, Boran H, Yandi I, Altinok I. Effects of some pesticides on the vital organs of juvenile rainbow trout (Oncorhynchus mykiss). Tissue Cell. 2010;42:376-82 pubmed publisher
    ..Fish had cell necrosis, degeneration and oedemas in liver, trunk kidney and spleen. None of these lesions were seen in control fish...
  10. Geissen V, Ramos F, de J Bastidas Bastidas P, Díaz González G, Bello Mendoza R, Huerta Lwanga E, et al. Soil and water pollution in a banana production region in tropical Mexico. Bull Environ Contam Toxicol. 2010;85:407-13 pubmed publisher
    ..5 and 4.3 ?g L?¹, respectively), but not with manganese. In deep ground water, no ethylenethiourea was detected. The level of pollution in the region presents a worrisome risk for aquatic life and for human health...
  11. Santos P, Simões T, Sá Correia I. Insights into yeast adaptive response to the agricultural fungicide mancozeb: a toxicoproteomics approach. Proteomics. 2009;9:657-70 pubmed publisher
    ..Our results also suggest that this study provided powerful indications that may be useful to expand the knowledge obtained in yeast not only to the global response to mancozeb toxicity in phytopathogenic fungi but also to humans...
  12. Corsini E, Birindelli S, Fustinoni S, De Paschale G, Mammone T, Visentin S, et al. Immunomodulatory effects of the fungicide Mancozeb in agricultural workers. Toxicol Appl Pharmacol. 2005;208:178-85 pubmed
  13. Singh S, Bano F, Mohanty B. Vitamin E pretreatment prevents the immunotoxicity of dithiocarbamate pesticide mancozeb in vitro: A comparative age-related assessment in mice and chick. Pestic Biochem Physiol. 2016;126:76-84 pubmed publisher
    ..The in vitro preventive effect of Vitamin E has also been explored on toxicity induced by mancozeb. The increased susceptibility observed both in early and aged groups was due to less/decline competence of the immune system. ..
  14. Hemavathi E, Rahiman M. Toxicological effects of ziram, thiram, and dithane M-45 assessed by sperm shape abnormalities in mice. J Toxicol Environ Health. 1993;38:393-8 pubmed
    ..All three of the fungicides tested were found to induce significant increase in the frequency of abnormal sperm at all the doses, and a linear dose effect was observed...
  15. Jacobsen P, Christiansen S, Boberg J, Nellemann C, Hass U. Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats. Int J Androl. 2010;33:434-42 pubmed publisher
    ..In addition, the sexual differentiation of the offspring was affected. This as well as the predictability of the combination effects based on dose-additivity modelling will be studied further in a large dose-response study...
  16. Kimura T, Kuroki K, Doi K. Dermatotoxicity of agricultural chemicals in the dorsal skin of hairless dogs. Toxicol Pathol. 1998;26:442-7 pubmed
    ..ACs examined were pentachlorophenol sodium salt, 2,4-dichlorophenoxyacetic acid (DCPAA), Maneb, and Zineb. One day after cessation of the 7-day AC treatment, the skin treated with DCPPA and Maneb indicated only slight ..
  17. Paro R, Tiboni G, Buccione R, Rossi G, Cellini V, Canipari R, et al. The fungicide mancozeb induces toxic effects on mammalian granulosa cells. Toxicol Appl Pharmacol. 2012;260:155-61 pubmed publisher
    ..These results further substantiate the concept that mancozeb should be regarded as a reproductive toxicant...
  18. Colosio C, Fustinoni S, Birindelli S, Bonomi I, De Paschale G, Mammone T, et al. Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers. Toxicol Lett. 2002;134:133-40 pubmed
    ..770 and 0.702, P=0.009 and 0.024, respectively). Wine consumption positively influenced the excretion of ETU...
  19. Rocha L, Luz C. Utility of six fungicides for selective isolation of Evlachovaea sp. and Tolypocladium cylindrosporum. Mycopathologia. 2009;167:341-50 pubmed publisher
    ..Thiabendazole, which is easy to obtain and can be used in low quantities, showed the greatest utility for a selective medium with these entomopathogenic fungi...
  20. Liu K, Kim C, Kim J. Human exposure assessment to mancozeb during treatment of mandarin fields. Bull Environ Contam Toxicol. 2003;70:336-42 pubmed
  21. Viviani B, Bartesaghi S, Binaglia M, Corsini E, Boraso M, Grazi E, et al. Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells. Toxicol Lett. 2008;182:63-8 pubmed publisher
    ..These data suggest that dithiocarbamates, through the activation of intracellular cascade(s), impair cytoskeletal actin. This effect may contribute to affect synaptic vesicles processing resulting in an impaired cholinergic transmission...
  22. Wojdyła A. Chitosan (biochikol 020 PC) in the control of some ornamental foliage diseases. Commun Agric Appl Biol Sci. 2004;69:705-15 pubmed
    ..Observations made during next spring showed that effectiveness of chitosan (Biochikol 020 PC) was more than 50% (long programme) and below 50% (short programme)...
  23. Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016;41:78-88 pubmed publisher
    ..Maneb and Mancozeb treatment results in intracellular metal accumulation leading to the oxidative stress. The metal moiety and the organic portion of EBDCs contribute to toxicity. ..
  24. La Pera L, Dugo G, Rando R, Di Bella G, Maisano R, Salvo F. Statistical study of the influence of fungicide treatments (mancozeb, zoxamide and copper oxychloride) on heavy metal concentrations in Sicilian red wine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:302-13 pubmed publisher
  25. Hwang E, Cash J, Zabik M. Ozone and hydrogen peroxyacetic acid treatment to reduce or remove EBDCs and ETU residues in a solution. J Agric Food Chem. 2001;49:5689-94 pubmed
    ..The results showed that ozone and HPA gave excellent degradation of pesticide residues depending on pH and temperature. These experiments indicated the potential for the removal of pesticide residues on fruit and in processed products...
  26. Tyagi S, George J, Singh R, Bhui K, Shukla Y. Neoplastic alterations induced in mammalian skin following mancozeb exposure using in vivo and in vitro models. OMICS. 2011;15:155-67 pubmed publisher
    ..Conclusively, we herein present the first report asserting that the mechanism involving S100A6 and S100A9 regulated ERK1/2 signaling underlies the mancozeb-induced neoplastic potential in human skin...
  27. Malik A, Sharma V, Sharma V, Rao A. Column preconcentration and spectrophotometric determination of ziram and zineb in commercial samples and foodstuffs using (1,2'-pyridylazo)-2-naphthol (PAN)-naphthalene as adsorbate. J Agric Food Chem. 2004;52:7763-7 pubmed
    ..for the determination of zinc(II) bis(dimethyldithiocarbamate) (ziram) and zinc(II) ethylenebis(dithiocarbamate) (zineb) after preconcentration on a column using naphthalene-(1,2'-pyridylazo)-2-naphthol (PAN) as adsorbent...
  28. Bindali B, Kaliwal B. Anti-implantation effect of a carbamate fungicide mancozeb in albino mice. Ind Health. 2002;40:191-7 pubmed
    ..Inhibition of implantation by mancozeb may be due to hormonal imbalance or its toxic effects...
  29. Singh A, Chhatpar H. Purification and characterization of chitinase from Paenibacillus sp. D1. Appl Biochem Biotechnol. 2011;164:77-88 pubmed publisher
    ..The present study is the first report on thermodynamic and kinetic characterization of chitinase from Paenibacillus sp. D1...
  30. Shi B, Chen L, Chou K, Haug A. Elevation of intracellular free calcium levels in sperm in response to long-term feeding of fungicides to mice. J Environ Sci Health B. 1992;27:1-8 pubmed
    ..of long-term feeding of fungicides on sperm quality, mice were fed a daily diet containing a mixture of maneb and zineb, at concentrations of 30, 300, and 3000 ppm, respectively...
  31. Iorio R, Castellucci A, Rossi G, Cinque B, Cifone M, Macchiarelli G, et al. Mancozeb affects mitochondrial activity, redox status and ATP production in mouse granulosa cells. Toxicol In Vitro. 2015;30:438-45 pubmed publisher
    ..Our results demonstrate that the low dose of MZ here used induces a mild oxidative stress in GCs, and provides evidence for the possible involvement of AKT/PKB signaling pathway in triggering adaptive and survival response. ..
  32. Prijono D, Robinson M, Rauf A, Bjorksten T, Hoffmann A. Toxicity of chemicals commonly used in Indonesian vegetable crops to Liriomyza huidobrensis populations and the Indonesian parasitoids Hemiptarsenus varicornis, Opius sp., and Gronotoma micromorpha, as well as the Australian parasitoids Hemiptarsenus. J Econ Entomol. 2004;97:1191-7 pubmed
    ..Local Australian parasitoids should help control L. huidobrensis as long as only cyromazine and nontoxic fungicides are applied...
  33. Malik A, Kapoor J, Rao A. Simple and sensitive spectrophotometric determination of ziram, zineb and ferbam in commercial samples and foodstuffs using phenylfluorone. J Environ Monit. 2000;2:367-71 pubmed
    A procedure has been developed for the determination of ziram, zineb and ferbam dithiocarbamate pesticides by converting ziram and zineb into a zinc-phenylfluorone complex and ferbam into an iron phenylfluorone complex, which are then ..
  34. Singh P. Synthesis and fungicidal activity of novel 3-(substituted/unsubstituted phenylselenonyl)-1-ribosyl/deoxyribosyl-1H-1,2,4-triazole. J Agric Food Chem. 2012;60:5813-8 pubmed publisher
  35. García Santos G, Keller Forrer K. Avoidance behaviour of Eisenia fetida to carbofuran, chlorpyrifos, mancozeb and metamidophos in natural soils from the highlands of Colombia. Chemosphere. 2011;84:651-6 pubmed publisher
    ..However, for the case of carbofuran and methamidophos, differences of more than double in avoidance were obtained. Divergence might be explained by soil and temperature conditions...
  36. Rossi G, Buccione R, Baldassarre M, Macchiarelli G, Palmerini M, Cecconi S. Mancozeb exposure in vivo impairs mouse oocyte fertilizability. Reprod Toxicol. 2006;21:216-9 pubmed
    ..Moreover, at this dose mancozeb caused a significant decrease of fertilizability related to a reduction of the formation of male and female pronuclei...
  37. Wang W, Han X, Zhang X, Kang L, Chen S. Synergism in mixtures of cymoxanil and mancozeb on Phytophthora infestans in vivo. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67:299-305 pubmed
  38. Jia Z, Misra H. Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: role of NFkappaB and caspase-3. Free Radic Biol Med. 2007;42:288-98 pubmed
    ..We have, therefore, examined the role of oxidative stress caused by the pesticides endosulfan and zineb in human neuroblastoma cells (SH-SY5Y) in culture...
  39. Genet J, Jaworska G, Deparis F. Effect of dose rate and mixtures of fungicides on selection for QoI resistance in populations of Plasmopara viticola. Pest Manag Sci. 2006;62:188-94 pubmed
    ..These results suggest that the choice of the fungicide partner and its dosage in the mixture can significantly affect the success of QoI resistance management strategies under practical conditions...
  40. Flampouri K, Mavrikou S, Kintzios S, Miliadis G, Aplada Sarlis P. Development and validation of a cellular biosensor detecting pesticide residues in tomatoes. Talanta. 2010;80:1799-804 pubmed publisher
    ..The experimental results showed a higher increase of the intracellular Ca(2+) concentration in cells treated with non-organic samples compared to the cells treated with organic samples...
  41. Hwang E, Cash J, Zabik M. Chlorine and chlorine dioxide treatment to reduce or remove EBDCs and ETU residues in a solution. J Agric Food Chem. 2002;50:4734-42 pubmed
    ..Treatment with both chlorine and chlorine dioxide at pH 4.6, yielded no ETU residues at both 10 and 21 degrees C. The results show that chlorine dioxide gives excellent degradation effects at lower concentrations than liquid chlorine...
  42. Cabras P, Angioni A, Garau V, Melis M, Pirisi F, Cabitza F, et al. The effect of simulated rain on folpet and mancozeb residues on grapes and on vine leaves. J Environ Sci Health B. 2001;36:609-18 pubmed
    ..The data obtained in these experiments show that, in the case of folpet, it is not necessary to repeat the treatment when it rains the day after, while it is recommendable to repeat it in the case of mancozeb...
  43. Andrioli N, Soloneski S, Larramendy M, Mudry M. Cytogenetic and microtubule array effects of the zineb-containing commercial fungicide formulation Azzurro(®) on meristematic root cells of Allium cepa L. Mutat Res. 2012;742:48-53 pubmed publisher
    b>Zineb [ethylene bis(dithiocarbamate) zinc] is a widely employed foliar fungicide for agricultural and industrial applications. Allium cepa L. is a reliable model for the assessment of xenobiotic genotoxicity and cytotoxicity...
  44. Mohapatra S, Deepa M. Residue dynamics of fenamidone and mancozeb on gherkin under two agro climatic zones in the state of Karnataka, India. Bull Environ Contam Toxicol. 2012;88:507-10 pubmed publisher
    ..02 and 0.1 mg kg(-1), respectively in both gherkin and soil. Residues of fenamidone and mancozeb in soil collected on the 20th day from the 2 locations were found to be below quantifiable limit of both fungicides...
  45. Hanumantharaju T, Awasthi M. Persistence and degradation of metalaxyl, mancozeb fungicides and its metabolite ethylenethiourea in soils. J Environ Sci Eng. 2004;46:312-21 pubmed
    ..Amongsoils, degradation of either mancozeb or ETU is not influenced by soil types. However, mancozeb persistence was higher in Hiriyur soils than Chettalli and Bangalore soils...
  46. Bisson M, Hontela A. Cytotoxic and endocrine-disrupting potential of atrazine, diazinon, endosulfan, and mancozeb in adrenocortical steroidogenic cells of rainbow trout exposed in vitro. Toxicol Appl Pharmacol. 2002;180:110-7 pubmed
    ..The in vitro adrenal bioassay can be used for screening of adrenotoxicants and for mechanistic studies of adrenotoxicity...
  47. Paramasivam M, Chandrasekaran S. Dynamics and residues of mixed formulation of fenamidone and mancozeb in gherkin field ecosystem. Ecotoxicol Environ Saf. 2013;98:292-6 pubmed publisher
    ..02 µg/g) and just after treatment for mancozeb (2 µg/g). These results can be utilized in formulating the spray schedule and safety evaluation for these pesticides in gherkin...
  48. Tsang M, Trombetta L. The protective role of chelators and antioxidants on mancozeb-induced toxicity in rat hippocampal astrocytes. Toxicol Ind Health. 2007;23:459-70 pubmed
    ..Mancozeb-induced cytotoxicity in astroyctes can be protected by BHT and that this antioxidant increased the total cellular antioxidant capacity...
  49. Crnogorac G, Schwack W. Determination of dithiocarbamate fungicide residues by liquid chromatography/mass spectrometry and stable isotope dilution assay. Rapid Commun Mass Spectrom. 2007;21:4009-16 pubmed
    ..03 mg kg(-1) and 0.05 mg kg(-1), respectively. Recoveries from grapes, cucumbers, tomatoes, and rucola, spiked in the range of 0.01-0.9 mg kg(-1), averaged between 90 and 100%...
  50. Colosio C, Fustinoni S, Corsini E, Bosetti C, Birindelli S, Boers D, et al. Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: an Italian study. Biomarkers. 2007;12:574-88 pubmed
    ..Altogether the differences between exposed and controls were not consistently correlated to any clinical impairment and suggest that the seasonal application of mancozeb does not pose a significant health risk to exposed subjects...
  51. Steenland K. Carcinogenicity of EBDCs. Environ Health Perspect. 2003;111:A266; author reply A266-7 pubmed
  52. Rekanovic E, Potocnik I, Milijašević Marčić S, Stepanovic M, Todorovic B, Mihajlović M. Toxicity of metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb to Phytophthora infestans isolates from Serbia. J Environ Sci Health B. 2012;47:403-9 pubmed publisher
    ..3% of isolates were sensitive to azoxystrobin and 50% to metalaxyl. Gout's scale indicated that 41.7% isolates were moderately sensitive to azoxystrobin and 50% to metalaxyl...
  53. Potera C. Assessing the impact of aerial pesticide spraying: mancozeb exposures among pregnant women living near banana plantations. Environ Health Perspect. 2014;122:A337 pubmed publisher