ditiocarb

Summary

Summary: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.

Top Publications

  1. Prabhu H, Nandini M. Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol. Indian J Exp Biol. 2007;45:465-8 pubmed
    ..It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation...
  2. Pang H, Chen D, Cui Q, Dou Q. Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells. Int J Mol Med. 2007;19:809-16 pubmed
    ..Our data support the concept of using accumulated copper in cancer cells and tissues as a novel target for chemotherapy. This study provides a mechanistic interpretation for utilization of copper chelators in cancer treatment...
  3. Domínguez M, Blasco Ibáñez J, Crespo C, Nacher J, Marqués Marí A, Martínez Guijarro F. Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation. Epilepsia. 2006;47:887-99 pubmed
    ..The objective of this work was to study the developing of the lesion in this model of temporal lobe epilepsy and the implications of the different types of glutamate receptors...
  4. Lushchak V, Semchyshyn H, Lushchak O, Mandryk S. Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells. Biochem Biophys Res Commun. 2005;338:1739-44 pubmed
    ..The results are discussed from the point of view that in vivo Cu,Zn-SOD of S. cerevisiae can demonstrate both anti- and pro-oxidant properties...
  5. Obminska Mrukowicz B, Szczypka M. Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice. J Vet Sci. 2005;6:25-32 pubmed
    ..The obtained results show that DTC administration can be supplemented with zinc in order to restore the immune system impaired by stress...
  6. Kimoto Kinoshita S, Nishida S, Tomura T. Diethyldithiocarbamate can induce two different type of death: apoptosis and necrosis mediating the differential MAP kinase activation and redox regulation in HL60 cells. Mol Cell Biochem. 2004;265:123-32 pubmed
    ..However, the mitochondrial transmembrane potential was remarkably decreased in the DDC-induced necrosis. Finally, duration of c-Jun N-terminal kinase (JNK) activation resulted in different types of cell death...
  7. Bink A, Vandenbosch D, Coenye T, Nelis H, Cammue B, Thevissen K. Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole. Antimicrob Agents Chemother. 2011;55:4033-7 pubmed publisher
    ..albicans biofilms is linked to the ROS-detoxifying activity of Sods. Moreover, Sod inhibitors can be used to potentiate the activity of miconazole against C. albicans biofilms...
  8. Lee S, Lee M, Chung W, Liu J. WAPK, a Ser/Thr protein kinase gene of Nicotiana tabacum, is uniquely regulated by wounding, abscisic acid and methyl jasmonate. Mol Gen Genet. 1998;259:516-22 pubmed
    ..These results suggest that the WAPK gene is regulated by ABA in the wound signal transduction pathway...
  9. Lushchak V, Bagnyukova T, Lushchak O, Storey J, Storey K. Diethyldithiocarbamate injection induces transient oxidative stress in goldfish tissues. Chem Biol Interact. 2007;170:1-8 pubmed
    ..Different actions of the superoxide anion in cellular metabolism and possible consequences of the impairment of superoxide dismutase are discussed...

More Information

Publications62

  1. Han Y, Kim S, Kim S, Park W. Enhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthionine sulfoximine. Int J Oncol. 2008;33:205-13 pubmed
    ..and GSH depletion in ATO-treated cells. In conclusion, the changes in intracellular GSH levels rather than ROS levels are tightly related to the enhancement of ATO-induced apoptosis in HeLa cells by DDC or BSO...
  2. Byrne S, Gu P, Zhou J, Denkin S, Chong C, Sullivan D, et al. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007;51:4495-7 pubmed
    ..13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally...
  3. Cvek B, Dvorak Z. Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals. Curr Pharm Des. 2007;13:3155-67 pubmed
    ..Future research should aim to find the most suitable dithiocarbamate coordination compounds for treatment of cancer and other diseases...
  4. Kang J, Wei Y, Zheng R. Effects of diethyldithiocarbamate on proliferation, redifferention, and apoptosis in human hepatoma cells. Acta Pharmacol Sin. 2001;22:785-92 pubmed
    ..To examine the effects of diethyldithiocarbamate (DDC) on the proliferation, redifferentiation, and apoptosis in human hepatoma cells...
  5. Goldschmidt J, Zuschratter W, Scheich H. High-resolution mapping of neuronal activity by thallium autometallography. Neuroimage. 2004;23:638-47 pubmed
    ..Clusters of layer Vb pyramidal cells and their apical dendrite bundles are clearly visible in the center of the columns...
  6. Tonkin E, Valentine H, Milatovic D, Valentine W. N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve. Toxicol Sci. 2004;81:160-71 pubmed
    ..Additionally lipid peroxidation appears to either be a contributing event in the development of demyelination, possibly through an increase of redox active copper, or a consequence of the myelin injury...
  7. Kanno S, Matsukawa E, Miura A, Shouji A, Asou K, Ishikawa M. Diethyldithiocarbamate-induced cytotoxicity and apoptosis in leukemia cell lines. Biol Pharm Bull. 2003;26:964-8 pubmed
    ..In conclusion, we suggest that DDTC-induced cytotoxicity was via an oxidative shift in the intracellular redox state, and accompanied the activation of endonuclease through apoptosis in leukemia cell lines...
  8. Viquez O, Valentine H, Amarnath K, Milatovic D, Valentine W. Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy. Toxicol Appl Pharmacol. 2008;229:77-85 pubmed publisher
    ..This relationship is consistent with copper-mediated oxidative stress contributing to the myelinopathy...
  9. Blondeau N, Widmann C, Lazdunski M, Heurteaux C. Activation of the nuclear factor-kappaB is a key event in brain tolerance. J Neurosci. 2001;21:4668-77 pubmed
  10. Valentine H, Viquez O, Amarnath K, Amarnath V, Zyskowski J, Kassa E, et al. Nitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury. Chem Res Toxicol. 2009;22:218-26 pubmed publisher
  11. Goldschmidt J, Wanger T, Engelhorn A, Friedrich H, Happel M, Ilango A, et al. High-resolution mapping of neuronal activity using the lipophilic thallium chelate complex TlDDC: protocol and validation of the method. Neuroimage. 2010;49:303-15 pubmed publisher
    ..We present a protocol for mapping neuronal activity with cellular resolution, which is based on intravenous TlDDC injections during ongoing activity in unrestrained behaving animals and short stimulation times of 5 min...
  12. Spiller S, Logsdon N, Deckard L, Sontheimer H. Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo. BMC Cancer. 2011;11:136 pubmed publisher
    ..Nuclear factor kappa-B (NF?B) is a signaling pathway that controls transcriptional activation of genes important for tight regulation of many cellular processes and is aberrantly expressed in many types of cancer...
  13. Wanger T, Scheich H, Ohl F, Goldschmidt J. The use of thallium diethyldithiocarbamate for mapping CNS potassium metabolism and neuronal activity: Tl+ -redistribution, Tl+ -kinetics and Tl+ -equilibrium distribution. J Neurochem. 2012;122:106-14 pubmed publisher
    ..A theoretical guideline is given for the use of K(+) -analogues for imaging neuronal activity with general implications for the use of metal ions in neuroimaging...
  14. Kaplan C, Petersen E, Yocum D, Hersh E. A randomized, controlled dose response study of intravenous sodium diethyldithiocarbamate in patients with advanced human immunodeficiency virus infection. Life Sci. 1989;45:iii-ix pubmed
    ..Further controlled clinical trials of DTC in earlier HIV infection are warranted...
  15. Han Y, Park W. The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. Oncol Rep. 2009;22:385-91 pubmed
    ..In conclusion, our results suggest that GSH depletion rather than ROS level in AMA-treated Calu-6 cells is more tightly related to apoptosis...
  16. Pratt Hyatt M, Lin H, Hollenberg P. Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate. Drug Metab Dispos. 2010;38:2286-92 pubmed publisher
    ..2 and CYP2E1.4, and the k(inact) values were 0.0061 and 0.0187 min(-1), respectively. These data indicate that DDC is a much less efficient inactivator of CYP2E1.2 than it is of either the wild-type or the CYP2E1.4 variant...
  17. Viquez O, Valentine H, Friedman D, Olson S, Valentine W. Peripheral nerve protein expression and carbonyl content in N,N-diethlydithiocarbamate myelinopathy. Chem Res Toxicol. 2007;20:370-9 pubmed
  18. Burkitt M, Bishop H, Milne L, Tsang S, Provan G, Nobel C, et al. Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species. Arch Biochem Biophys. 1998;353:73-84 pubmed
    ..This observation is consistent with our proposed mechanism of dithiocarbamate toxicity, which involves their copper-catalyzed conversion to cytotoxic thiuram disulfides...
  19. Xu K, Kuppusamy P. Dual effects of copper-zinc superoxide dismutase. Biochem Biophys Res Commun. 2005;336:1190-3 pubmed
    ..OH radical scavenger. Our results shed new light on the effect of dysfunctional CuZnSOD and suggest that structural disorder of the enzyme may be one of the endogenous pathways of toxic (.)OH formation in biological systems...
  20. Komarov A, Mattson D, Mak I, Weglicki W. Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice. FEBS Lett. 1998;424:253-6 pubmed
    ..e. after iNOS expression. This is a first report demonstrating iron-dependent iNOS down-regulation in endotoxin-treated mice...
  21. Ahmed S, Baker L, Grainger R, Innocenti P, Quevedo C. Thermal elimination of diethyldithiocarbamates and application in the synthesis of (+/-)-ferrugine. J Org Chem. 2008;73:8116-9 pubmed publisher
    ..2.2] bridged bicyclic amide, which was converted in a one-pot procedure to the 8-azabicyclo[3.2.1]octane ring system of the tropane alkaloid ferrugine by treatment with phenyllithium followed by aqueous sodium hydroxide...
  22. Lipsky J, Shen M, Naylor S. Overview--in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites. Chem Biol Interact. 2001;130-132:81-91 pubmed
    ..Finally we show using SEC-MS that both DSF and MeDTC-SO do not prevent formation of the homotetramer of rmALDH, but inhibit the enzyme by acting directly at the active site of specific monomers of rmALDH...
  23. Lenda D, Boegehold M. Effect of a high salt diet on microvascular antioxidant enzymes. J Vasc Res. 2002;39:41-50 pubmed
    ..These findings suggest that endogenous Cu/Zn SOD preserves the endothelium-dependent control of arteriolar tone in NS rats, and that a reduction in Cu/Zn SOD activity contributes to the loss of arteriolar NO activity in HS rats...
  24. Li Y, Hu B, He M, Xiang G. Simultaneous speciation of inorganic selenium and antimony in water samples by electrothermal vaporization inductively coupled plasma mass spectrometry following selective cloud point extraction. Water Res. 2008;42:1195-203 pubmed
    ..5% for Se(IV) and 4.2% for Sb(III) (C=1.00 microg L(-1), n=5). The proposed method was applied to the speciation of inorganic selenium and antimony in different water samples with satisfactory results...
  25. Paravicini T, Gulluyan L, Dusting G, Drummond G. Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits. Circ Res. 2002;91:54-61 pubmed
    ..However, endothelium-dependent vasorelaxation is largely preserved due to the actions of Cu2+/Zn2+-SOD and increased smooth muscle sensitivity to nitric oxide...
  26. Shokoji T, Nishiyama A, Fujisawa Y, Hitomi H, Kiyomoto H, Takahashi N, et al. Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension. 2003;41:266-73 pubmed
    ..These results suggest that augmented superoxide production contributes to the development of hypertension through activation of the sympathetic nervous system...
  27. Szatrowski T, Nathan C. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 1991;51:794-8 pubmed
  28. Lin R, Buijse L, Dimitrov M, Dohmen P, Kosol S, Maltby L, et al. Effects of the fungicide metiram in outdoor freshwater microcosms: responses of invertebrates, primary producers and microbes. Ecotoxicology. 2012;21:1550-69 pubmed publisher
    ..i./L. At higher treatment levels, including the test systems that received the highest dose, ecological recovery of affected measurement endpoints was fast (effect period < 8 weeks)...
  29. Dogterom P, Nagelkerke J, Van Steveninck J, Mulder G. Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carb. Chem Biol Interact. 1988;66:251-65 pubmed
    ..In the presence of DSF or DDC, cell death occurred even earlier in time. We conclude that cell death can occur in the absence of lipid peroxidation. Therefore, lipid peroxidation is not a requisite for the induction of cell death...
  30. Greenberg S, Ouyang J, Zhao X, Xie J, Wang J, Giles T. Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo. J Pharmacol Exp Ther. 1997;282:1044-54 pubmed
    ..Finally, ethanol inhibits iNOS at the level of transcription and at the level of the enzyme...
  31. Kumar R, Hooda V, Pundir C. Purification and partial characterization of oxalate oxidase from leaves of forage Sorghum (Sorghum vulgare var. KH-105) seedlings. Indian J Biochem Biophys. 2011;48:42-6 pubmed
    ..The positive reaction of the enzyme with orcinol-H2SO4 reagent indicated its glycoprotein nature. The superiority of the purified enzyme over earlier reported oxalate oxidases for determination of urinary oxalate has been demonstrated...
  32. Georgiadis M, Cai Y, Solo Gabriele H. Extraction of arsenate and arsenite species from soils and sediments. Environ Pollut. 2006;141:22-9 pubmed
    ..5% NaDDC where AsIII oxidation was clearly minimized. The combined phosphate and NaDDC solution was applied to several soil and sediment samples. AsIII spiked was quantitatively recovered in all soil types tested...
  33. Costa A, Ramos J, Téllez Soto C, Martin A, Raniero L, Ondar G, et al. Fourier Transform Infrared and Raman spectra, DFT: B3LYP/6-311G(d, p) calculations and structural properties of bis(diethyldithiocarbamate)copper(II). Spectrochim Acta A Mol Biomol Spectrosc. 2013;105:259-66 pubmed publisher
    ..The calculated infrared and Raman spectra, based on the proposed geometrical structure of the bis(diethyldithiocarbamate)copper(II) complex, agreed with the experimental spectra...
  34. Krasnodebska Ostrega B, Sadowska M, Piotrowska K, Wojda M. Thallium (III) determination in the Baltic seawater samples by ICP MS after preconcentration on SGX C18 modified with DDTC. Talanta. 2013;112:73-9 pubmed publisher
    ..10 ng for Tl(I) and 0.43 ng for Tl(III). The method was applied to the determination of Tl(I) and Tl(III) in the Baltic seawater samples enriched in both thallium species...
  35. Sheets P, Yost G, Carlson G. Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1. J Biochem Mol Toxicol. 2004;18:92-9 pubmed
    ..6). Thus, these studies have demonstrated in human lung cell lines that benzene is bioactivated by two lung-expressed p450 enzymes...
  36. Rayatzadeh H, Nouri M, Ghasemi M, Kebriaeezadeh A, Mehr S, Dehpour A. Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice. Seizure. 2009;18:51-6 pubmed publisher
    ..Cholestasis decreased seizure activity and increased lag phase before seizure and both effects were decreased by dithizone injection. It is elicited that zinc may mediate the cholestasis-induced decrement in seizure activity...
  37. Saxena S, Mathur A, Srivastava R. Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential. Antivir Chem Chemother. 2003;14:91-8 pubmed
    ..Interestingly, DDTC alone did not stimulate iNOS and TNF-alpha in mock-infected normal mice. These results show that DDTC may have a possible therapeutic role during JEV infection...
  38. Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, et al. Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2012;56:4140-5 pubmed publisher
    ..tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB...
  39. Xiao Y, Ling J, Qian S, Lin A, Zheng W, Xu W, et al. Preconcentration of trace arsenite and arsenate with titanium dioxide nanoparticles and subsequent determination by silver diethyldithiocarbamate spectrophotometric method. Water Environ Res. 2007;79:1015-22 pubmed
    ..The method was also applied to the analysis of arsenite and arsenate in natural water samples to verify the accuracy. The recovery values remained in a narrow range, from 95 to 103%...
  40. Osawa T, Naito T, Suzuki N, Imai K, Nakanishi K, Kawakami J. Validated method using liquid chromatography-electrospray ionization tandem mass spectrometry for the determination of contamination of the exterior surface of vials containing platinum anticancer drugs. Talanta. 2011;85:1614-20 pubmed publisher
    ..This validated method using LC-ESI-MS/MS for the determination of platinum anticancer drugs is helpful for monitoring contamination of the exterior surface of drug vials...
  41. Gerber I, Dubery I. Fluorescence microplate assay for the detection of oxidative burst products in tobacco cell suspensions using 2',7'-dichlorofluorescein. Methods Cell Sci. 2003;25:115-22 pubmed
  42. Wang Y, Hu C, Liu M, Jiang H, Huo R, Dong D. Copper induces vasorelaxation and antagonizes noradrenaline-induced vasoconstriction in rat mesenteric artery. Cell Physiol Biochem. 2013;32:1247-54 pubmed publisher
    ..The aim of the study was to investigate the effects of copper on vascular tone of rat mesenteric artery and compare the effects of copper on noradrenaline (NA) and high K(+) induced vasoconstriction...
  43. Williams C, Lin Y, Maynard A, Cheng S. Involvement of NF kappa B in potentiated effect of Mn-containing dithiocarbamates on MPP(+) induced cell death. Cell Mol Neurobiol. 2013;33:815-23 pubmed publisher
    ..This study demonstrates that activation of NF-?B is responsible for the potentiated toxic effect of MB and MZ on MPP(+) induced cytotoxicity...
  44. Téllez Soto C, Costa A, Ramos J, Vieira L, Rost N, Versiane O, et al. Surface enhanced Raman scattering, electronic spectrum, natural bond orbital, and Mulliken charge distribution in the normal modes of diethyldithiocarbamate copper (II) complex, [Cu(DDTC)2]. Spectrochim Acta A Mol Biomol Spectrosc. 2013;116:546-55 pubmed publisher
    ..Full assignment of the SERS spectra was also supported by carefully analysis of the distorted geometries generated by the normal modes. ..
  45. Meng L, Cheng J, Yang Y. Supramolecular solvent-based extraction coupled with vortex-mixing for determination of palladium and silver in water samples by flame atomic absorption spectrometry. Water Sci Technol. 2014;69:580-6 pubmed publisher
    ..8 and 1.9 ?g/L and the enrichment factors were 36 and 18 for Pd and Ag, respectively. The quantification limits were 3.2 and 2.4 ?g/L. The method was successfully applied to the determination of Pd and Ag in water samples. ..
  46. Skelly M, O Donoghue D, Baird A. Oxygen metabolites in immune- stimulated ion transport in rat colon: modulation by taurine. Digestion. 2001;63:124-9 pubmed
    ..In this investigation we examined whether indirect (immune) stimulation of ion transport across rat colon was ROM-mediated...
  47. Kiviluoto T, Watanabe S, Hirose M, Sato N, Mustonen H, Puolakkainen P, et al. Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1151-7 pubmed
    ..NO donors retard gastric wound healing by inhibiting migration and proliferation and inducing cell apoptosis. These effects do not seem to be mediated via cGMP, but O2(-*). or peroxynitrites may be involved...
  48. Makino A, Skelton M, Zou A, Cowley A. Increased renal medullary H2O2 leads to hypertension. Hypertension. 2003;42:25-30 pubmed
  49. Garcia Pascual A, Labadia A, Costa G, Triguero D. Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra. Br J Pharmacol. 2000;129:53-62 pubmed
    ..Our results do not support the view that the urethral nitrergic transmitter is free NO, and the possibility that another compound is acting as mediator still remains open. British Journal of Pharmacology (2000) 129, 53 - 62..
  50. Tatrai E, Kovacikova Z, Karacsony G, Hudak A, Adamis Z, Ungvary G. Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro. J Toxicol Environ Health A. 2001;62:207-16 pubmed
    ..The membranes of pneumocytes type II were injured. Data show that DDTC adversely affected type II pneumocyte function and structure...
  51. Wang M, Etheridge J, Thompson J, Vorwald C, Dean D, Fisher J. Evaluation of the in vitro cytotoxicity of cross-linked biomaterials. Biomacromolecules. 2013;14:1321-9 pubmed publisher
    ..Overall, the cytotoxicity response of the cells to PPF was demonstrated to be similar to the cytotoxic response of cells to known noncytotoxic materials (HDPE)...
  52. Matos G, Arruda M. Improvements in cobalt determination by thermospray flame furnace atomic absorption spectrometry using an on-line derivatization strategy. Talanta. 2008;76:475-8 pubmed publisher
    ..Good agreement between the results at the 95% confidence level was observed...
  53. Rodriguez Puyol M, Griera Merino M, Perez Rivero G, Diez Marques M, Ruiz Torres M, Rodriguez Puyol D. Angiotensin II induces a rapid and transient increase of reactive oxygen species. Antioxid Redox Signal. 2002;4:869-75 pubmed
    ..The mechanism may be related to the previously proposed role of H(2)O(2) in the genesis of the Ang II-induced cell contraction...