dimethyldithiocarbamate

Summary

Summary: A chemical that acts as a dopamine beta-hydroxylase inhibitor. Its salts are agricultural fungicides. It is inferior to diethyldithiocarbamate as a chelating agent.

Top Publications

  1. Macaluso M, Larson R, Lynch J, Lipton S, Delzell E. Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workers. J Occup Environ Hyg. 2004;1:371-90 pubmed
    Quantitative estimates of exposure to 1,3-butadiene (BD), styrene (STY), and dimethyldithiocarbamate (DMDTC) were developed for a follow-up study of workers at six North American synthetic rubber plants...
  2. Hwang H, Kim J, Eu Y, Moon B, Cho S, Lee C. Photoinhibition of photosystem I is accelerated by dimethyldithiocarbamate, an inhibitor of superoxide dismutase, during light-chilling of spinach leaves. J Photochem Photobiol B. 2004;73:79-85 pubmed
    ..The possible dissociation of LHC I as an early structural change in the PS I complex after DDC-induced photoinhibition of PS I is discussed...
  3. Delap S, Skeeles J, Beasley J, Kreider D, Whitfill C, Houghten G, et al. In vivo studies with dimethyldithiocarbamate, a possible new antimicrobial for use against Aspergillus fumigatus in poultry. Avian Dis. 1989;33:497-501 pubmed
    b>Dimethyldithiocarbamate (DmDTC), the carbamate analogue, was tested for therapeutic efficacy in a series of in vivo challenge trials using 5- and 10-week-old white leghorn chickens...
  4. Scharf B, Trombetta L. The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Long-Evans rats. Toxicol Lett. 2007;174:117-24 pubmed
    The potential toxic effects on human health and deleterious effects to the environment by copper dimethyldithiocarbamate (CDDC), an alternative wood preservative to chromated copper arsenate (CCA) have not been investigated...
  5. Delzell E, Macaluso M, Sathiakumar N, Matthews R. Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industry. Chem Biol Interact. 2001;135-136:515-34 pubmed
    This study evaluated relations between exposure to 1,3-butadiene (BD), styrene (STY) and dimethyldithiocarbamate (DMDTC) and mortality from leukemia among synthetic rubber industry workers...
  6. Tilton F, La Du J, Vue M, Alzarban N, Tanguay R. Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicol Appl Pharmacol. 2006;216:55-68 pubmed
    ..This indicates that the perturbation of no tail expression is in response to the muscle contractions distorting the notochord, while collagen 2a1 is associated with the impact of these molecules on much earlier developmental processes...
  7. Lenartowicz M, Krzeptowski W, Koteja P, Chrząścik K, Møller L. Prenatal treatment of mosaic mice (Atp7a mo-ms) mouse model for Menkes disease, with copper combined by dimethyldithiocarbamate (DMDTC). PLoS ONE. 2012;7:e40400 pubmed publisher
    ..murine fetuses throughout gestation days 7, 11, 15 and 18 with a combination of CuCl(2) (50 mg/kg) and dimethyldithiocarbamate (DMDTC) (280 mg/kg) leads to an increase in survival to about 76±25...
  8. Scharf B, Trombetta L. Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of Long-Evans rats. J Toxicol Environ Health A. 2008;71:1300-6 pubmed publisher
    ..accumulation of copper in the livers and kidneys of Long-Evans rats after a subacute exposure to copper dimethyldithiocarbamate (CDCC) wood preservative...
  9. Guo H, Xing B, Hamlet L, Chica A, He L. Surface-enhanced Raman scattering detection of silver nanoparticles in environmental and biological samples. Sci Total Environ. 2016;554-555:246-52 pubmed publisher

More Information

Publications57

  1. Malik A. Spectrophotometric determination of ferbam (iron(III) dimethyldithiocarbamate) in commercial sample and wheat grains using 4,7-diphenyl-1,10-phenanthroline after extraction into mesityl oxide. J Environ Monit. 2000;2:151-3 pubmed
    A procedure has been developed for the determination of iron(III) dimethyldithiocarbamate by converting it into iron(II)-bathophenanthroline complex, which is then extracted into mesityl oxide in the presence of potassium perchlorate...
  2. Stook K, Dubey B, Ward M, Townsend T, Bitton G, Solo Gabriele H. Heavy metal toxicity of pressure treated wood leachates with MetPLATE. Bull Environ Contam Toxicol. 2004;73:987-94 pubmed
  3. Fu F, Xiong Y, Xie B, Chen R. Adsorption of Acid Red 73 on copper dithiocarbamate precipitate-type solid wastes. Chemosphere. 2007;66:1-7 pubmed
    ..N,N'-bis(dithiocarboxy)piperazine ([CuBDP](n)), copper diethyldithiocarbamate (Cu(DDTC)(2)) and copper dimethyldithiocarbamate (Cu(DMTC)(2)), were prepared and tested as adsorbents to remove Acid Red 73 from wastewater...
  4. Goldman J, Murr A, Buckalew A, Ferrell J, Cooper R. Moderating influence of the drinking water disinfection by-product dibromoacetic acid on a dithiocarbamate-induced suppression of the luteinizing hormone surge in female rats. Reprod Toxicol. 2007;23:541-9 pubmed
    ..in triggering a luteinizing hormone (LH) surge, or to affect the ability of the neurotoxicant sodium dimethyldithiocarbamate (DMDC) to block the surge...
  5. Pyatt D, Gruntmeir J, Stillman W, Irons R. Dimethyldithiocarbamate inhibits in vitro activation of primary human CD4+ T lymphocytes. Toxicology. 1998;128:83-90 pubmed
    ..studies described herein were undertaken to investigate the immunotoxicity of one member of this family, dimethyldithiocarbamate (DMDTC). We demonstrate that 0.1-0...
  6. Elskens M, Penninckx M. Thiram and dimethyldithiocarbamic acid interconversion in Saccharomyces cerevisiae: a possible metabolic pathway under the control of the glutathione redox cycle. Appl Environ Microbiol. 1997;63:2857-62 pubmed
    ..The underlying mechanism of this effect possibly involves the intracellular oxidation of dimethyldithiocarbamate anions to thiram, which in turn oxidizes GSH...
  7. Goldman J, Murr A, Buckalew A, Cooper R. Suppression of the steroid-primed luteinizing hormone surge in the female rat by sodium dimethyldithiocarbamate: relationship to hypothalamic catecholamines and GnRH neuronal activation. Toxicol Sci. 2008;104:107-12 pubmed publisher
    ..Sodium dimethyldithiocarbamate (DMDC) is a pesticide with metal chelating properties that has been found to reduce DbetaH activity...
  8. Quinto I, De Marinis E, Mallardo M, Arcucci A, Della Morte R, Staiano N. Effect of DNOC, Ferbam and Imidan exposure on mouse sperm morphology. Mutat Res. 1989;224:405-8 pubmed
    ..w./day. These data indicate that per os administration of Ferbam succeeded in producing active metabolites able to interfere with the differentiation process of spermatogenic cells...
  9. Delap S, Skeeles J, Kreider D, Whitfill C, Beasley J, Houghten G, et al. In vitro studies with dimethyldithiocarbamate, possible new antimicrobial for use in poultry. Avian Dis. 1989;33:8-11 pubmed
    Tests were conducted to determine the in vitro efficacy of the dithiocarbamate analogue, dimethyldithiocarbamate (DmDTC), against selected poultry pathogens...
  10. Walker E, Hardin H, Gale G, Reifsteck M, Cannon D, Jones M. Antipseudomonal effects of selected dithiocarbamates alone and in combination with gentamicin or aztreonam. Res Commun Chem Pathol Pharmacol. 1989;63:101-17 pubmed
    ..b>Dimethyldithiocarbamate (DMDTC), diethyldithiocarbamate (DEDTC), and sodium N-methyl-D-glucamine dithiocarbamate (NMGDTC) were ..
  11. McFarland M, Glarborg C, Ross M. Chemical treatment of chelated metal finishing wastes. Water Environ Res. 2012;84:2086-9 pubmed
    ..The second approach evaluated the use of sodium dimethyldithiocarbamate (DMDTC) to specifically target and precipitate regulated heavy metals...
  12. Chou A, Maidment N, Klintenberg R, Casida J, Li S, Fitzmaurice A, et al. Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome. J Biol Chem. 2008;283:34696-703 pubmed publisher
    ..Sodium dimethyldithiocarbamate administered to mice for 2 weeks resulted in persistent motor deficits and a mild reduction in striatal ..
  13. Giovagnini L, Mancinetti E, Ronconi L, Sitran S, Marchio L, Castagliuolo I, et al. Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate. J Inorg Biochem. 2009;103:774-82 pubmed publisher
    ..The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl(3)] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines...
  14. Hackenberg F, Oehninger L, Alborzinia H, Can S, Kitanovic I, Geldmacher Y, et al. Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells. J Inorg Biochem. 2011;105:991-9 pubmed publisher
    ..The observation of a dose-dependent inhibition of the oxygen consumption of isolated mice mitochondria indicates the involvement of an intrinsic mitochondrial pathway in this process...
  15. Thompson R, Valentine H, Valentine W. In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate and N,N-dimethyldithiocarbamate in the rat. Toxicol Sci. 2002;70:269-80 pubmed
    ..suggest that NMDC may exert greater acute toxicity following oral exposure than its dialkyl analog,N,N-dimethyldithiocarbamate (DMDC)...
  16. Shanthi R, Krishnamoorthy M. Evaluation of the aneugenic potential of the fungicide Ferbam in mice. Teratog Carcinog Mutagen. 2002;22:451-9 pubmed
    ..There was no significant induction of either hyperdiploidy or hypodiploidy by Ferbam, unlike colchicine, indicating that the fungicide Ferbam is not aneugenic in the mouse test system...
  17. Lei G, Gao P, Liu H, Huang C. Real-time scattered light dark-field microscopic imaging of the dynamic degradation process of sodium dimethyldithiocarbamate. Nanoscale. 2015;7:20709-16 pubmed publisher
    ..define their degradation mechanisms, herein we real-time monitored the decomposition dynamics of sodium dimethyldithiocarbamate (NaDDC) under neutral and alkaline conditions by imaging single silver nanoparticles (AgNPs) under a dark-..
  18. Green T, Toghill A, Moore R. The influence of co-exposure to dimethyldithiocarbamate on butadiene metabolism. Chem Biol Interact. 2001;135-136:585-98 pubmed
    Treatment of rats and mice with a single oral dose of dimethyldithiocarbamate (DMDTC; 250 mg/kg) had a marked effect on hepatic CYP2E1 and aldehyde dehydrogenase activities, measured in vitro, for up to 24 h after dosing...
  19. Malik A, Rao A. Spectrophotometric determination of ziram in a commercial sample and wheat by extraction of its copper dimethyldithiocarbamate complex into molten naphthalene. J AOAC Int. 2002;85:146-8 pubmed
    A method was developed for the determination of zinc(II) dimethyldithiocarbamate by converting it into the copper(II) dithiocarbamate complex, which is then extracted into molten naphthalene...
  20. Sekkat N, Le Du A, Jouany J, Guerbet M. Study of the interactions between copper, cadmium, and ferbam using the protozoan Colpidium campylum bioassay. Ecotoxicol Environ Saf. 1992;24:294-300 pubmed
    ..The results show that, at the concentrations tested, a synergy occurs between cadmium and ferbam, whereas the copper is only oligodynamic...
  21. Bird M, Lewis D, Whitman F, Lewis R, Przygoda R, Witz G. Application of process chemistry and SAR modelling to the evaluation of health findings of lower olefins. Chem Biol Interact. 2001;135-136:571-84 pubmed
    ..A detailed review of the SBR manufacturing process indicates that sodium dimethyldithiocarbamate (DMDTC) introduced into the SBR manufacturing process for a period in the 1950s coincides with increased ..
  22. Ujjani B, Lyman S, Winkelmann D, Antholine W, Petering D, Jones M. Enhancement of cytotoxicity of bleomycin by dithiocarbamates: formation of bis(dithiocarbamato) cu(II). J Inorg Biochem. 1990;38:81-93 pubmed
    ..Ferric tris-diethyldithiocarbamate is also a cytotoxic species. In contrast, when cells are exposed to dimethyldithiocarbamate or its copper complex in Ringer's buffer under metal-restricted condition, washed, and then placed in ..
  23. Borg K, Tjälve H. Effect of thiram and dithiocarbamate pesticides on the gastrointestinal absorption and distribution of nickel in mice. Toxicol Lett. 1988;42:87-98 pubmed
    Oral administration of dimethyldithiocarbamate pesticides (ferbam, ziram or sodium dimethyldithiocarbamate) or thiram together with nickel resulted in increased levels of the metal in several tissues of rats, in comparison with animals ..
  24. Malik A. Determination of the fungicide ferbam in wheat grains after adsorption onto microcrystalline naphthalene. J AOAC Int. 2000;83:971-5 pubmed
    A procedure was developed for the determination of iron(III) dimethyldithiocarbamate by converting it into iron(II)-bathophenanthroline-tetraphenylborate complex, which was then adsorbed onto microcrystalline naphthalene...
  25. Pyatt D, Yang Y, Le A, Stillman W, Irons R. Dithiocarbamates inhibit hematopoiesis via a copper-dependent mechanism. Biochem Biophys Res Commun. 2000;274:513-8 pubmed
    ..These data support a role for copper in DTC-induced hematotoxicity...
  26. Naumov P, Ng S. Experimental and theoretical vibrational study of bis(N,N-dimethylthiocarbamoylthio)acetic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2001;57:1289-94 pubmed
    ..The calculated spectrum compares well with the experimental solid-state FT IR spectrum recorded at 298 and at 77 K...
  27. Mutoh N, Kawabata M, Hayashi Y. Tetramethylthiuram disulfide or dimethyldithiocarbamate induces the synthesis of cadystins, heavy metal chelating peptides, in Schizosaccharomyces pombe. Biochem Biophys Res Commun. 1991;176:1068-73 pubmed
    Tetramethylthiuram disulfide (TMTD) or dimethyldithiocarbamate (DMDTC) induces the synthesis of cadystins, a family of heavy metal chelating isopeptides with the formula (gamma-Glu-Cys)n-Gly (n = 2,3,4,.....
  28. Matsumoto K, Fujibayashi Y, Konishi J, Yokoyama A. [Radiolabeling and biodistribution of 62Cu-dithiocarbamate--an application for the new 62Zn/62Cu generator]. Radioisotopes. 1990;39:482-6 pubmed
    ..Further studies with Cu-dithiocarbamic acid derivatives for development of new generator-produced 62Cu positron radiopharmaceuticals can be recalled...
  29. Padhye L, Kim J, Huang C. Oxidation of dithiocarbamates to yield N-nitrosamines by water disinfection oxidants. Water Res. 2013;47:725-36 pubmed publisher
    Two most commonly used dithiocarbamate (DTC) pesticides, dimethyldithiocarbamate (DMDTC) and diethyldithiocarbamate (DEDTC), were examined in this study to evaluate their potential to form nitrosamines when in contact with various water ..
  30. Masukawa T, Nakanishi K, Katakawa J, Tetsumi T. Protection against alloxan-induced diabetes by various dialkyldithiocarbamates. Experientia. 1995;51:29-31 pubmed
  31. Srikanth S, Berk S. Stimulatory effect of cooling tower biocides on amoebae. Appl Environ Microbiol. 1993;59:3245-9 pubmed
    ..Biocides used to control microbial growth may actually enhance populations of host organisms for pathogenic bacteria...
  32. Cheng H, Sathiakumar N, Graff J, Matthews R, Delzell E. 1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships. Chem Biol Interact. 2007;166:15-24 pubmed
    ..regression coefficient adjusted for all covariates (age, year of birth, race, plant, years since hire and dimethyldithiocarbamate) was similar in magnitude (beta=3.0 x 10(-4), p=0.04)...
  33. Lester P, Thistlewood H, Marshall D, Harmsen R. Assessment of Amblyseius fallacis (Acari: Phytoseiidae) for biological control of tetranychid mites in an Ontario peach orchard. Exp Appl Acarol. 1999;23:995-1009 pubmed
    ..However, further research is necessary into the timing and rate of release, modified spray programmes, and with different crops, in order to clarify the role of this species for biological control in Ontario peach orchards...
  34. Malik A, Rao A. Spectrophotometric determination of ferbam [iron(III) dimethyl dithiocarbamate] in commercial sample and wheat grains after extraction of its bathophenanthroline tetraphenylborate complex into molten naphthalene. J Agric Food Chem. 2000;48:4044-7 pubmed
    A procedure has been developed for the determination of iron(III) dimethyldithiocarbamate by converting it into a iron(III)-bathophenanthroline-tetraphenylborate complex, which was then extracted into molten naphthalene, and the ..
  35. Endo K, Hayashi Y, Hibi T, Hosono K, Beppu T, Ueda K. Enzymological characterization of EpoA, a laccase-like phenol oxidase produced by Streptomyces griseus. J Biochem. 2003;133:671-7 pubmed
    ..EpoA-like activities were detected in cell extracts of 8/40 environmental actinomycetes strains, which suggests that similar oxidases are widely distributed among this group of bacteria...
  36. Malik A, Bansal S, Aulakh J. Fourth-derivative spectrophotometric determination of fungicide ferbam (iron(III) dimethyldithiocarbamate) in a commercial sample and wheat grains using 2,2'-bipyridyl. Anal Bioanal Chem. 2003;375:1250-3 pubmed
    ..has been developed for the direct fourth-derivative spectrophotometric determination of iron(III) dimethyldithiocarbamate by converting it into an iron(II) 2,2'-bipyridyl complex, which is then dissolved in Triton X-100...
  37. Malik A, Seidel B, Faubel W. Capillary electrophoretic determination of ferric dimethyldithiocarbamate as iron(III) chelate of EDTA. J Chromatogr A. 1999;857:365-8 pubmed
    ..electrophoretic method with UV detection has been developed for the determination of Ferbam (ferric dimethyldithiocarbamate) in boric acid buffer after its acidic decomposition and complexation with EDTA as Fe-EDTA- complex...
  38. Aulakh J, Fekete A, Malik A, Mahajan R, Schmitt Kopplin P. Capillary electrophoretic-ultraviolet method for the separation and estimation of zineb, maneb, and ferbam in food samples. J AOAC Int. 2007;90:834-7 pubmed
    ..with ultraviolet detection has been developed for the separation and determination of ferbam [iron(III)-dimethyldithiocarbamate], maneb [manganese(II)-ethylenebisdithiocarbamate] and zineb [zinc(II)-ethylenebisdithiocarbamate], in ..
  39. Goldman J, Parrish M, Cooper R, McElroy W. Blockade of ovulation in the rat by systemic and ovarian intrabursal administration of the fungicide sodium dimethyldithiocarbamate. Reprod Toxicol. 1997;11:185-90 pubmed
    ..The current experiments investigated whether the dithiocarbamate fungicide dimethyldithiocarbamate (DMDTC) would block oocyte release in normally cycling rats when administered systemically during the ..
  40. Montine T, Underhill T, Valentine W, Graham D. Dialkyldithiocarbamates inhibit tyrosine hydroxylase activity in PC12 cells and in fibroblasts that express tyrosine hydroxylase. Neurodegeneration. 1995;4:283-90 pubmed
    ..Diethyldithiocarbamate (DEDC), dimethyldithiocarbamate (DMDC), and methyldithiocarbamate (MDC) were examined for their ability to inhibit tyrosine hydroxylase (..
  41. Guo Y, Smith K, Petris M. Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clusters. J Biol Chem. 2004;279:46393-9 pubmed
    ..Treatment with the metal chelator dimethyldithiocarbamate disassembled the hCtr1 multimer following cisplatin exposure, suggesting that platinum was an integral ..
  42. Jing X, Liu F, Yang X, Ling P, Li L, Long C, et al. Adsorption performances and mechanisms of the newly synthesized N,N'-di (carboxymethyl) dithiocarbamate chelating resin toward divalent heavy metal ions from aqueous media. J Hazard Mater. 2009;167:589-96 pubmed publisher
    ..Negative values of DeltaG(o) indicated that adsorption processes for all tested metal ions onto PSDC were spontaneous...
  43. Borg K, Gottofrey J, Tjälve H. Effects of some chelating agents on the uptake and distribution of 203Hg2+ in the brown trout (Salmo trutta): studies on ethyl- and isopropylxanthate, diethyl- and diisopropyldithiophosphate, dimethyl- and diethyldithiocarbamate and pyridinethione. Arch Toxicol. 1988;62:387-91 pubmed
    ..SIX), sodium diethyldithiophosphate (SEP), sodium diisopropyldithiophosphate (SIP), sodium dimethyldithiocarbamate (SMC), sodium diethyldithiocarbamate (SEC) or sodium pyridinethione (SPyr), respectively...
  44. Saute B, Premasiri R, Ziegler L, Narayanan R. Gold nanorods as surface enhanced Raman spectroscopy substrates for sensitive and selective detection of ultra-low levels of dithiocarbamate pesticides. Analyst. 2012;137:5082-7 pubmed publisher
    ..95 nM, 25.61 ± 1.01 nM, and 12.94 ± 1.22 nM for thiram, ferbam, and ziram respectively. It can be seen that the three different dithiocarbamates can be detected in the low nM range based on the limits of detection that are achieved...
  45. Malik A, Kapoor J, Rao A. Simple and sensitive spectrophotometric determination of ziram, zineb and ferbam in commercial samples and foodstuffs using phenylfluorone. J Environ Monit. 2000;2:367-71 pubmed
    ..The method is sensitive, highly selective and can be used for the determination of ziram, zineb and ferbam in commercial samples and in foodstuffs...
  46. Srivastava R, Gupta S, Ahmad N, Hasan S, Farookh A, Husain M. Comparative evaluation of chelating agents on the mobilization of cadmium: a mechanistic approach. J Toxicol Environ Health. 1996;47:173-82 pubmed
    ..479), and (3) percent survival and percent transport (r =.447). However, the lipophilicity did not show any appreciable correlation with percent survival and stability constant of Cd chelates...
  47. Wedge D, Nagle D. A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. J Nat Prod. 2000;63:1050-4 pubmed
    ..Mixtures of structurally diverse antifungal agents were tested to establish the validity and utility of this method in the discovery of new natural products with activity against agriculturally important fungal pathogens...
  48. Malik A. Direct spectrophotometric determination of ferbam (Iron(III) dimethyldithiocarbamate) in commercial sample and wheat grains using 4,7-diphenyl-1,10-phenanthroline. J Agric Food Chem. 2000;48:5808-11 pubmed
    A procedure has been developed for the determination of iron(III) dimethyldithiocarbamate by converting it into the iron(II)-bathophenanthroline complex, which is then dissolved in acetone-water (1:1), and the absorbance is measured at ..