thiocarbamates

Summary

Summary: Carbamates in which the -CO- group has been replaced by a -CS- group.

Top Publications

  1. Morais C, Gobe G, Johnson D, Healy H. Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma. Apoptosis. 2010;15:412-25 pubmed publisher
    ..The major mechanism of the synergistic effect appears to be mediated by the inhibition of transcription activity of NF-kappaB rather than its expression, and the resultant decrease in the anti-apoptotic proteins Bcl-2 and Bcl-(XL)...
  2. Morais C, Gobe G, Johnson D, Healy H. Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor. Angiogenesis. 2009;12:365-79 pubmed publisher
    ..Collectively, these data suggest that PDTC has some anti-angiogenic properties, which may limit development and progression of RCC...
  3. Sunil Y, Ramadori G, Raddatzc D. Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC. Int J Colorectal Dis. 2010;25:323-33 pubmed publisher
    ..Therefore, we aimed to evaluate the efficacy of compounds known to disrupt the NFkappaB pathway on NFkappaB transcriptional activity and CXCL8 and CXCL10 gene expression in intestinal cell lines...
  4. Kan S, Huang F, Tang J, Gao Y, Yu C. Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury. Inflammation. 2010;33:287-94 pubmed publisher
    ..PDTC might inhibit the activation of NF-kappaB and then reduce the expression of iNOSmRNA and effectively alleviate the severity of lung injury...
  5. Pfeilschifter W, Czech B, Hoffmann B, Sujak M, Kahles T, Steinmetz H, et al. Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?. Neurochem Res. 2010;35:1391-401 pubmed publisher
    ..The attenuation of apoptotic cell death in brain microvascular endothelial cells is dependent on p38 MAPK activity...
  6. Allen E, Anderson D, Florang V, Khanna M, Hurley T, Doorn J. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition. Chem Res Toxicol. 2010;23:1843-50 pubmed publisher
    ..It was determined that molinate sulfone is capable of covalently modifying Cys residues, including catalytic Cys302 of ALDH, accounting for the observed enzyme inhibition...
  7. Chabicovsky M, Prieschl Grassauer E, Seipelt J, Muster T, Szolar O, Hebar A, et al. Pre-clinical safety evaluation of pyrrolidine dithiocarbamate. Basic Clin Pharmacol Toxicol. 2010;107:758-67 pubmed publisher
    ..Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues...
  8. Oh D, Bang J, Choi H, Yang H, Yoo M, Kim K. Fetal bovine serum requirement for pyrrolidine dithiocarbamate-induced apoptotic cell death of MCF-7 breast tumor cells. Eur J Pharmacol. 2010;649:135-9 pubmed publisher
  9. Cichero E, Cesarini S, Fossa P, Spallarossa A, Mosti L. Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. Eur J Med Chem. 2009;44:2059-70 pubmed publisher
    b>Thiocarbamates (TCs) have been recently identified as a new class of potent non-nucleoside HIV-1 Reverse Transcriptase (RT) inhibitors...

More Information

Publications62

  1. Nurmi A, Vartiainen N, Pihlaja R, Goldsteins G, Yrjänheikki J, Koistinaho J. Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window. J Neurochem. 2004;91:755-65 pubmed
    ..The clinically approved PDTC and its analogues may act as anti-inflammatories and may be safe therapies in stroke with a wide time window...
  2. Kabay B, Teke Z, Aytekin F, Yenisey C, Bir F, Sacar M, et al. Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. World J Surg. 2007;31:1707-15 pubmed
    ..It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion...
  3. Nai Y, Jiang Z, Wang Z, Li N, Li J. Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice. JPEN J Parenter Enteral Nutr. 2007;31:18-25 pubmed
    ..This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice...
  4. Ferreira Z, Fernandes P, Duma D, Assreuy J, Avellar M, Markus R. Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B. J Pineal Res. 2005;38:182-8 pubmed
    ..To the best of our knowledge, this is the first time that this relevant pathway for passive and acquired immune response is shown to modulate melatonin production in pineal gland...
  5. Malaguarnera L, Pilastro M, DiMarco R, Scifo C, Renis M, Mazzarino M, et al. Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate. Apoptosis. 2003;8:539-45 pubmed
    ..These findings imply that normal cells are equipped with mechanisms by which they respond differently to PDTC effects with respect to leukemic cells...
  6. Tsuchihashi S, Tamaki T, Tanaka M, Kawamura A, Kaizu T, Ikeda A, et al. Pyrrolidine dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1. Surgery. 2003;133:556-67 pubmed
    ..We examined the impact of PDTC preconditioning against cold ischemia and reperfusion injury in the rat liver...
  7. Gu J, Young E, Busby B, Covington J, Johnson J. Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice. Cancer Biol Ther. 2009;8:514-21 pubmed publisher
    ..These results support the hypothesis that PDTC suppresses tumor angiogenesis, growth, and migration of breast cancer via inhibiting autocrine and paracrine effects of VEGF through the reduction of NF?B activation and VEGF expression...
  8. Moon S, Jung S, Choi Y, Lee Y, Patterson C, Kim C. PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase. J Cell Physiol. 2004;198:310-23 pubmed
    ..In conclusion, an understanding of the molecular mechanisms of PDTC in VSMC provides a theoretical basis for clinical approaches using antioxidant therapies in atherosclerosis...
  9. Cesarini S, Spallarossa A, Ranise A, Fossa P, La Colla P, Sanna G, et al. Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates. Bioorg Med Chem. 2008;16:4160-72 pubmed publisher
    In order to expand the structure-activity relationship (SAR) studies on Thiocarbamates (TCs), a recently discovered class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors, 38 analogues of the lead O-[2-(2-pyridyl)ethyl]-N-..
  10. Calderón Segura M, Gómez Arroyo S, Molina Alvarez B, Villalobos Pietrini R, Calderón Ezquerro C, Cortés Eslava J, et al. Metabolic activation of herbicide products by Vicia faba detected in human peripheral lymphocytes using alkaline single cell gel electrophoresis. Toxicol In Vitro. 2007;21:1143-54 pubmed
    ..The alkaline comet technique is a rapid and sensitive assay, to quickly evaluate DNA damage the metabolic activation of herbicide products by V. faba root in human cells in vitro...
  11. Zhou M, Shi J, Hang C, Cheng H, Qi X, Mao L, et al. Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. J Cereb Blood Flow Metab. 2007;27:1583-92 pubmed
    ..Our results suggest that NF-kappaB is activated in the arterial wall after SAH, which potentially leads to vasospasm development through induction of inflammatory response...
  12. Zimmerman L, Valentine H, Valentine W. Characterization of S-(N,N-Dialkylaminocarbonyl)cysteine Adducts and Enzyme Inhibition Produced by Thiocarbamate Herbicides in the Rat. Chem Res Toxicol. 2004;17:258-67 pubmed
    b>Thiocarbamates are a major class of herbicides used extensively in the agricultural industry...
  13. Liu G, Wang S, Wang B, Kong B. Inhibition of nuclear factor-kappaB by an antioxidant enhances paclitaxel sensitivity in ovarian carcinoma cell line. Int J Gynecol Cancer. 2006;16:1777-82 pubmed
    ..Combining antioxidants and paclitaxel has significant potential to overcome the risk of paclitaxel resistance...
  14. Nurmi A, Lindsberg P, Koistinaho M, Zhang W, Juettler E, Karjalainen Lindsberg M, et al. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke. 2004;35:987-91 pubmed
    ..Because a considerable number of middle cerebral artery occlusions (MCAOs) in humans are not associated with reperfusion during the first 24 hours, the role of NF-kappaB after permanent MCAO (pMCAO) was investigated...
  15. Cheng A, Huang T, Lai C, Kuo J, Huang Y, Lo C, et al. Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells. J Agric Food Chem. 2006;54:4215-21 pubmed
    ..These results suggest that in the luteolin-induced apoptotic pathway, phosphorylation of procaspase-9 by survival signals might play an important role in the ultimate fate of HL-60 cells...
  16. Tamada S, Asai T, Kuwabara N, Iwai T, Uchida J, Teramoto K, et al. Molecular mechanisms and therapeutic strategies of chronic renal injury: the role of nuclear factor kappaB activation in the development of renal fibrosis. J Pharmacol Sci. 2006;100:17-21 pubmed
    ..It is suggested that strategy aiming at NF-kappaB inhibition is important to prevent the progression of renal fibrosis...
  17. Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005;96:791-800 pubmed
    ..Consistent with these findings, A-83-01 inhibited the epithelial-to-mesenchymal transition induced by TGF-beta, suggesting that A-83-01 and related molecules may be useful for preventing the progression of advanced cancers...
  18. Chen D, Peng F, Cui Q, Daniel K, Orlu S, Liu J, et al. Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis. Front Biosci. 2005;10:2932-9 pubmed
  19. Liu K, Chi D, Li C, Hall H, Milhorn D, Krishnaswamy G. HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling. Am J Physiol Lung Cell Mol Physiol. 2005;289:L252-60 pubmed
  20. Uchide N, Ohyama K. Antiviral function of pyrrolidine dithiocarbamate against influenza virus: the inhibition of viral gene replication and transcription. J Antimicrob Chemother. 2003;52:8-10 pubmed
  21. Spallarossa A, Cesarini S, Ranise A, Bruno O, Schenone S, La Colla P, et al. Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2009;44:1650-63 pubmed publisher
    The structure-activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further investigated...
  22. Parodi F, Mao D, Ennis T, Bartoli M, Thompson R. Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J Vasc Surg. 2005;41:479-89 pubmed
    ..The purpose of this study was to determine whether aneurysmal degeneration is influenced by pyrrolidine dithiocarbamate (PDTC), a pharmacologic inhibitor of NF-kappaB...
  23. Cloutier A, Ear T, Blais Charron E, Dubois C, McDonald P. Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils. J Leukoc Biol. 2007;81:567-77 pubmed
    ..Our data also raise the possibility that NF-kappaB or MAPK inhibitors could be useful in the treatment of inflammatory disorders in which neutrophils predominate...
  24. Crack P, Taylor J, Ali U, Mansell A, Hertzog P. Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury. Stroke. 2006;37:1533-8 pubmed
    ..This study was designed to elucidate the mechanisms involved in elevated neuronal cell death arising from an altered endogenous oxidant state...
  25. Ahtoniemi T, Goldsteins G, Keksa Goldsteine V, Malm T, Kanninen K, Salminen A, et al. Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. Mol Pharmacol. 2007;71:30-7 pubmed
    ..These results suggest that PDTC acts as an immunoproteasome inhibitor in mutant SOD1 rats and that immunoproteasome may help the nervous system to cope with deleterious effects of SOD1-G93A mutation...
  26. Kim J, Kim K, Na H, Jeong S, Park H, Kim S, et al. Tumor necrosis factor-? and interleukin-1? expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7. Mol Oral Microbiol. 2012;27:149-59 pubmed publisher
    ..These results show that S. mutans stimulates the production of TNF-? and IL-1? in the mouse macrophage cell line, RAW 264.7, by activating ERK/p38/JNK, and NF-?B through TLR2 and TLR4, respectively...
  27. Sun M, Chen K, Tsao Y, Kao L, Han W, Lin K, et al. Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats. Curr Eye Res. 2011;36:1053-63 pubmed publisher
  28. Jia T, Fu H, Sun J, Zhang Y, Yang W, Li Y. Foxp3 expression in A549 cells is regulated by Toll-like receptor 4 through nuclear factor-?B. Mol Med Rep. 2012;6:167-72 pubmed publisher
    ..In addition, the expression of NF-?B (p65) increased after LPS stimulation and the expression of Foxp3 decreased after blocking NF-?B. These results suggest that TLR4 is involved in the regulation of Foxp3 in A549 cells through NF-?B...
  29. Tang Y, Xie H, Chen J, Geng L, Chen H, Li X, et al. Activated NF-?B in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling. Stem Cells Dev. 2013;22:668-78 pubmed publisher
  30. Ide Y, Matsui T, Ishibashi Y, Takeuchi M, Yamagishi S. Pigment epithelium-derived factor inhibits advanced glycation end product-elicited mesangial cell damage by blocking NF-kappaB activation. Microvasc Res. 2010;80:227-32 pubmed publisher
    ..Our present study suggests that substitution of PEDF proteins may be a promising strategy for the treatment of diabetic nephropathy...
  31. Rezaee R, Hassanzadeh Khayyat M, Mehri F, Khashyarmanesh Z, Moallemzadeh H, Karimi G. Determination of parathion, aldicarb, and thiobencarb in tap water and bottled mineral water in Mashhad, Iran. Drug Chem Toxicol. 2012;35:192-8 pubmed publisher
  32. Chen Y, Chen K, Chen C, Wu H, Su C, Wu C, et al. Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways. Toxicol Lett. 2010;199:333-40 pubmed publisher
    ..Taken together, these results indicate that exposure to PDTC/Cu complex induces cytotoxicity and apoptosis in alveolar epithelial cells via the mitochondria- and ER-stress-related signaling pathways...
  33. Baldoni L, Stortz C, Marino C. Synthesis and conformational analysis of 1,2-cis fused bicyclic ?-d-galactofuranosyl thiocarbamate from per-O-tert-butyldimethylsilyl-?-d-galactofuranosyl isothiocyanate. Carbohydr Res. 2011;346:191-6 pubmed publisher
    ..In aqueous solution, the equilibrium favours the first conformation (3:1 ratio). On the other hand, this ratio decreases for less polar solvents...
  34. Wu K, Schmid Schonbein G. Nuclear factor kappa B and matrix metalloproteinase induced receptor cleavage in the spontaneously hypertensive rat. Hypertension. 2011;57:261-8 pubmed publisher
    ..These results suggest NF?B is an important transcription factor in the SHR and may be involved in the enhanced MMP activity and, consequently, receptor cleavage...
  35. Shimasaki Y, Tsuyama M, Tasmin R, Qiu X, Shimizu M, Sato Y, et al. Thiobencarb herbicide reduces growth, photosynthetic activity, and amount of Rieske iron-sulfur protein in the diatom Thalassiosira pseudonana. J Biochem Mol Toxicol. 2013;27:437-44 pubmed publisher
    ..Although the mechanism by which thiobencarb decreased the Rieske iron-sulfur protein level is not clear, these results suggest that growth was inhibited by interruption of the photosynthetic electron transport chain by thiobencarb...
  36. Guo X, Pan Y, Xiao C, Wu Y, Cai D, Gu J. Fractalkine stimulates cell growth and increases its expression via NF-?B pathway in RA-FLS. Int J Rheum Dis. 2012;15:322-9 pubmed publisher
    ..Fractalkine (FKN), also called CX3CL1, plays an important role in the proliferation of cells. FKN may stimulate the proliferation of RA-FLS and the by nuclear factor ?B (NF-?B) pathway may be one of the steps in this process...
  37. Karimy J, Zhang J, Kurland D, Theriault B, Duran D, Stokum J, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med. 2017;23:997-1003 pubmed publisher
  38. Wang Y, Zhang J, Zhao B, Du X, Ma J, Li J. Development of dispersive liquid-liquid microextraction based on solidification of floating organic drop for the determination of trace nickel. Biol Trace Elem Res. 2011;144:1381-93 pubmed publisher
    ..21% and 2.55%, respectively. The proposed method was assessed through the analysis of certified reference water or recovery experiments...
  39. Cotogni P, Bini R, Trombetta A, Olivero G. Pyrrolidine dithiocarbamate modulates HSP70, iNOS, and apoptosis during hemorrhagic shock resuscitation in rats. J Invest Surg. 2010;23:295-302 pubmed publisher
  40. Mudge S, Paizis K, Auwardt R, Levidiotis V, Fraser S, Power D. Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-?B in a model of membranous glomerulonephritis. Nephron Exp Nephrol. 2010;116:e23-31 pubmed publisher
    ..In this study, therefore, we have determined whether dexamethasone (DEX) and pyrrolidine dithiocarbamate (PDTC), therapies that inhibit NF-?B, influence proteinuria...
  41. Galhano V, Gomes Laranjo J, Peixoto F. Exposure of the cyanobacterium Nostoc muscorum from Portuguese rice fields to Molinate (Ordram(®)): Effects on the antioxidant system and fatty acid profile. Aquat Toxicol. 2011;101:367-76 pubmed publisher
    ..These evidences should be taken in account when using N. muscorum as an environmental indicator species in studies of herbicide biotransformation and biomarker response as well as in environmental monitoring programmes...
  42. Yu hui H, Yun F, Fen J, Xing L. [Study about cardiomyocyte apoptosis in myocardial ischemic-reperfusion injury of rats and NF-?B p65, iNOS expression]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010;26:868-70 pubmed
    ..Analysis of NF-?B and iNOS expression in the rat heart ischemic-reperfusion injury, apoptosis in the process of regulation and its mechanism...
  43. Dacho A, Hanusch C, Lyutenski S, Dietz A. Pyrrolidine dithiocarbamate as an effector and trigger in ischemia-reperfusion injury in adipocutaneous flaps in rats. J Otolaryngol Head Neck Surg. 2012;41:176-82 pubmed
  44. Van Boxtel A, Kamstra J, Fluitsma D, Legler J. Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity. Toxicol Appl Pharmacol. 2010;244:156-61 pubmed publisher
    ..Taken together, these results provide the first evidence that DTC induced teratogenic effects are, at least in part, caused by direct inhibition of LOX activity...
  45. Raspe C, Hocherl K, Rath S, Sauvant C, Bucher M. NF-?B-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis. Cytokine. 2013;61:97-103 pubmed publisher
  46. Li S, Zhong S, Zeng K, Luo Y, Zhang F, Sun X, et al. Blockade of NF-kappaB by pyrrolidine dithiocarbamate attenuates myocardial inflammatory response and ventricular dysfunction following coronary microembolization induced by homologous microthrombi in rats. Basic Res Cardiol. 2010;105:139-50 pubmed publisher
    ..Patients with or at risk of CME may benefit from acute anti-inflammatory treatment with PDTC...
  47. Liu S, Wang H, Tang J, Zhou X. Hypoxia-induced collagen synthesis of human lung fibroblasts by activating the angiotensin system. Int J Mol Sci. 2013;14:24029-45 pubmed publisher
    ..Our results indicate that Ang II-mediated NF-?B signalling via ATR is involved in hypoxia-induced collagen synthesis in human lung fibroblasts...
  48. Yeh P, Lin F, Lin C, Yang C, Chen M, Yang C. Expressions of lymphotactin and its receptor, XCR, in Lewis rats with experimental autoimmune anterior uveitis. Graefes Arch Clin Exp Ophthalmol. 2010;248:1737-47 pubmed publisher
    ..To demonstrate the expression of lymphotactin and its receptor (XCR) in the iris/ciliary body and popliteal lymph node, and to clarify their roles in experimental autoimmune anterior uveitis (EAAU)...
  49. Saka M. Acute toxicity of rice paddy herbicides simetryn, mefenacet, and thiobencarb to Silurana tropicalis tadpoles. Ecotoxicol Environ Saf. 2010;73:1165-9 pubmed publisher
    ..Therefore, the three herbicides can be harmful to amphibian larvae living in paddy water...
  50. Luckprom P, Wongkhantee S, Yongchaitrakul T, Pavasant P. Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells. J Periodontal Res. 2010;45:404-11 pubmed publisher
    ..In this study, we further investigated the effect of extracellular ATP on the expression of RANKL and the mechanism involved...
  51. Ronconi L, Aldinucci D, Dou Q, Fregona D. Latest insights into the anticancer activity of gold(III)-dithiocarbamato complexes. Anticancer Agents Med Chem. 2010;10:283-92 pubmed
  52. Yilmaz E, Soylak M. Ionic liquid-linked dual magnetic microextraction of lead(II) from environmental samples prior to its micro-sampling flame atomic absorption spectrometric determination. Talanta. 2013;116:882-6 pubmed publisher
    ..The accuracy of the developed method was evaluated by the analysis of the certified reference materials and addition-recovery tests. The method was successfully applied to the determination of lead in water, plant and hair samples...
  53. Lynch S, Mahajan R, Beane Freeman L, Hoppin J, Alavanja M. Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS). Environ Res. 2009;109:860-8 pubmed publisher
    ..27, 95% CI=1.18-4.37; NHL: RR(LD)=3.44, 95% CI=1.29-9.21). Our analysis did not find meaningful associations for other cancers analyzed. Further study is warranted for AL, NHL and prostate cancers...