methocarbamol

Summary

Summary: A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)

Top Publications

  1. Schlegelmilch R, Eydeler A, Barkworth M, Radeke A. Bioequivalence study with two different oral formulations of methocarbamol in healthy subjects. A mono-centre, comparative, randomized, open-label, single-dose, 2-way crossover study. Arzneimittelforschung. 2009;59:238-42 pubmed publisher
    The objective of this study was to compare the pharmacokinetic profile of a new oral methocarbamol (CAS 532-03-6) formulation (DoloVisano Methocarbamol 750 mg Tabletten) to that of a registered reference product and to demonstrate the ..
  2. Gholivand M, Khodadadian M. Rationally designed molecularly imprinted polymers for selective extraction of methocarbamol from human plasma. Talanta. 2011;85:1680-8 pubmed publisher
    Molecularly imprinted polymers (MIPs) with high selectivity toward methocarbamol have been computationally designed and synthesized based on the general non-covalent molecular imprinting approach...
  3. Elkady E. Simultaneous determination of diclofenac potassium and methocarbamol in ternary mixture with guaifenesin by reversed phase liquid chromatography. Talanta. 2010;82:1604-7 pubmed publisher
    ..RP-LC) method has been developed for the simultaneous determination of diclofenac potassium (DP) and methocarbamol (MT) in ternary mixture with guaifenesin (GF), degradation product of methocarbamol...
  4. Souri E, Sharifzadeh M, Farsam H, Gharavi N. Muscle relaxant activity of methocarbamol enantiomers in mice. J Pharm Pharmacol. 1999;51:853-5 pubmed
    ..shown that so far no report has been published on the pharmacological activity of individual enantiomers of methocarbamol. This study was conducted to characterize the muscle relaxant activity of methocarbamol enantiomers...
  5. Preston K, Wolf B, Guarino J, Griffiths R. Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability. J Pharmacol Exp Ther. 1992;262:707-20 pubmed
    The effects of orally administered placebo, diphenhydramine, lorazepam, methocarbamol and placebo were studied in volunteers with histories of recreational substance abuse including sedative/hypnotics...
  6. Zha W, Zhu Z. Determination of methocarbamol concentration in human plasma by high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:831-5 pubmed publisher
    ..and reproducible high performance liquid chromatography-tandem mass spectrometric method was developed for methocarbamol analysis in human plasma...
  7. Hoiriis K, Pfleger B, McDuffie F, Cotsonis G, Elsangak O, Hinson R, et al. A randomized clinical trial comparing chiropractic adjustments to muscle relaxants for subacute low back pain. J Manipulative Physiol Ther. 2004;27:388-98 pubmed
    ..Investigating appropriate care has proven difficult, since, in general, acute pain subsides spontaneously and chronic pain is resistant to intervention. Subacute back pain has been rarely studied...
  8. Farsam H, Souri E, Gharavi N. A new HPLC technique for the separation of methocarbamol enantiomers. J Pharm Pharmacol. 1999;51:873-5 pubmed
    ..have developed a stereoselective high-performance liquid chromatography technique for analytical separation of methocarbamol enantiomers...
  9. Ali N, Hegazy M, Abdelkawy M, Abdelaleem E. Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method. Acta Pharm. 2012;62:191-200 pubmed publisher
    Accurate and sensitive methods were developed for simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium in their binary mixtures, and in the presence of a methocarbamol related substance (guaifenesin) using ..

More Information

Publications39

  1. Weng N, Lee J, Hulse J. Development and validation of a high-performance liquid chromatographic method for the determination of methocarbamol in human plasma. J Chromatogr B Biomed Appl. 1994;654:287-92 pubmed
    An isocratic HPLC method was developed and validated for the quantitation of methocarbamol in human plasma...
  2. Alessi Severini S, Coutts R, Jamali F, Pasutto F. High-performance liquid chromatographic analysis of methocarbamol enantiomers in biological fluids. J Chromatogr. 1992;582:173-9 pubmed
    b>Methocarbamol enantiomers in rat and human plasma were quantified using a stereospecific high-performance liquid chromatographic method...
  3. Pouli N, Antoniadou Vyzas A, Foscolos G. Methocarbamol degradation in aqueous solution. J Pharm Sci. 1994;83:499-501 pubmed
    The kinetics of the hydrolysis of methocarbamol to the corresponding diol guaifenesin in aqueous solution was studied. Methocarbamol was rather stable in acidic media but easily hydrolyzed in alkaline solution...
  4. Draper W, Bolfer L, Cottam E, McMichael M, Schubert T. Methocarbamol CRI for symptomatic treatment of pyrethroid intoxication: a report of three cases. J Am Anim Hosp Assoc. 2013;49:325-8 pubmed publisher
    ..b>Methocarbamol, given as intermittent injections, is a common first-line treatment choice for the tremors associated with ..
  5. Obach R, Pruñonosa J, Menargues A, Nomen M, Valles J. Pharmacokinetics and bioavailability of methocarbamol in rats. Biopharm Drug Dispos. 1988;9:501-11 pubmed
    In a pharmacokinetic study, 15, 30, 60, and 150 mg kg-1 intravenous and oral doses of methocarbamol were administered to rats. Differences observed in plasma clearance values, i.e. 0.0203, 0.0156, 0.0123, and 0...
  6. Boakes J, Peach J, McGill S. Does methocarbamol affect fatigue markers in the low-back electromyogram?. J Electromyogr Kinesiol. 1998;8:423-7 pubmed
    ..The question that needed to be addressed was, do centrally acting muscle relaxants (methocarbamol; Robaxin) affect the EMG spectral indices of muscle fatigue that are often used to assess muscle performance...
  7. Amrick C, Bennett D. A comparison of diazepam stimuli in aged and adult rats. Psychopharmacology (Berl). 1987;93:292-5 pubmed
    ..Similar dose-dependent generalization with chlordiazepoxide, pentobarbital, and methocarbamol was also noted in both the aged and adult animals...
  8. Preston K, Guarino J, Kirk W, Griffiths R. Evaluation of the abuse potential of methocarbamol. J Pharmacol Exp Ther. 1989;248:1146-57 pubmed
    The subjective and behavioral effects of p.o. administered methocarbamol, lorazepam and placebo were studied in a nonresidential group of adult male volunteers with histories of recreational substance abuse including sedative/hypnotics...
  9. Jickling G, Heino A, Ahmed S. Acetaminophen toxicity with concomitant use of carbamazepine. Epileptic Disord. 2009;11:329-32 pubmed publisher
    ..5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage...
  10. Rosasco M, Ceresole R, Forastieri C, Segall A. A stability-indicating high-performance liquid chromatographic method for the determination of methocarbamol in veterinary preparations. J AOAC Int. 2009;92:1602-5 pubmed
    An isocratic HPLC method was developed and validated for the quantitation of methocarbamol in the presence of its degradation products...
  11. Ghoneim E, El Desoky H. Electrochemical determination of methocarbamol on a montmorillonite-Ca modified carbon paste electrode in formulation and human blood. Bioelectrochemistry. 2010;79:241-7 pubmed publisher
    ..MMT-Ca) clay, a MMT-Ca modified carbon paste electrode was developed for the sensitive determination of methocarbamol. Methocarbamol has been oxidized in buffered solutions at the developed MMT-Ca-modified CPE in a single 2-..
  12. Walash M, Belal F, Eid M, El Abass S. Spectrofluorometric determination of methocarbamol in pharmaceutical preparations and human plasma. J Fluoresc. 2011;21:555-61 pubmed publisher
    A simple, sensitive and rapid spectrofluorometric method for determination of methocarbamol in pharmaceutical formulations and spiked human plasma has been developed...
  13. Sica D, Comstock T, Davis J, Manning L, Powell R, Melikian A, et al. Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39:193-4 pubmed
    We determined plasma methocarbamol concentrations over 24 h following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic haemodialysis patients and compared these results to those from 17 healthy male volunteers...
  14. Pruitt B. Methocarbamol suspension for the treatment of rhabdomyolysis in equines. Int J Pharm Compd. 2013;17:384-7 pubmed
    Rhabdomyolysis in equines occurs in horses due to physical overexertion or underlying pathologic myopathy. Methocarbamol is a muscle relaxant that can be used in equines to treat symptoms associated with Rhabdomyolysis...
  15. Sahebari M, Jafarian A, Abbasi B. A case report of unusual vasculitic reaction after Methocarbamol injection. Acta Med Iran. 2011;49:192-4 pubmed
    ..These presentations are probably as a side effect of Methocarbamol injection...
  16. El Din M, Eid M, Zeid A. Simultaneous determination of methocarbamol and aspirin by RP-HPLC using fluorescence detection with time programming: its application to pharmaceutical dosage form. Luminescence. 2013;28:332-8 pubmed publisher
    ..reversed-phase liquid chromatographic method was developed and validated for the simultaneous determination of methocarbamol (MET) and aspirin (ASP) in their combined dosage form. The separation of these compounds was achieved within 6...
  17. Minai Tehrani D, Masoudnia A, Alavi S, Osmani R, Lotfi L, Asghari M, et al. Interaction of methocarbamol and yeast sucrase induces enzyme inhibition. Drug Metabol Drug Interact. 2012;27:225-8 pubmed
    b>Methocarbamol is a skeletal muscle relaxant and is widely used to relieve pain in muscles. Many drugs may have interactions with each other when used at the same time...
  18. Walker F. Seizure-like behavior in cats. Can Vet J. 2002;43:3 pubmed
  19. Sannerud C, Ator N. Drug discrimination analysis of midazolam under a three-lever procedure: I. Dose-dependent differences in generalization and antagonism. J Pharmacol Exp Ther. 1995;272:100-11 pubmed
    ..The muscle relaxant methocarbamol and nonsedative/anxiolytic drugs (morphine, caffeine and d-amphetamine) did not produce responding on the ..
  20. Oliveras Moreno J, Hernandez Pacheco E, Oliveras Quintana T, Infante Cossio P, Gutierrez Perez J. Efficacy and safety of sodium hyaluronate in the treatment of Wilkes stage II disease. J Oral Maxillofac Surg. 2008;66:2243-6 pubmed publisher
    ..hyaluronate (SH) into the temporomandibular joint (TMJ) would significantly reduce pain and improve joint function in Wilkes stage II disease, compared with the oral administration of a combination of methocarbamol and paracetamol.
  21. Parker A, Lee J, Redman J, Jolliffe L. Strychnine poisoning: gone but not forgotten. Emerg Med J. 2011;28:84 pubmed publisher
    ..Prompt recognition and early intensive supportive therapy can result in a favourable outcome...
  22. Rzeszutko W. [Determination of methocarbamol]. Acta Pol Pharm. 1990;47:17-9 pubmed
    Method of determination of 3-(2-metoxyfenoxy)-1,3-propandiol (Methocarbamol) with Marquisa reagent was verified. New method of quantitative determination based on the coloured reaction with Ce (IV) ion was developed.
  23. Looke T, Kluth C. Effect of preoperative intravenous methocarbamol and intravenous acetaminophen on opioid use after primary total hip and knee replacement. Orthopedics. 2013;36:25-32 pubmed publisher
    ..hip and knee replacement at one Florida medical center replaced preoperative oral analgesics with intravenous methocarbamol and intravenous acetaminophen...
  24. Kuo K, Odunayo A. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. J Vet Emerg Crit Care (San Antonio). 2013;23:436-41 pubmed publisher
    ..To describe the use of an intravenous lipid emulsion (ILE) as an adjunctive therapy in 2 cats with permethrin toxicity...
  25. Waszynski C. How to try this: detecting delirium. Am J Nurs. 2007;107:50-9; quiz 59-60 pubmed
    ..For a free online video demonstrating the use of this tool, go to http://links.lww.com/A209...
  26. Elkady E. Simultaneous spectrophotometric determination of diclofenac potassium and methocarbamol in binary mixture using chemometric techniques and artificial neural networks. Drug Test Anal. 2011;3:228-33 pubmed publisher
    In this study, the simultaneous determination of diclofenac potassium (DP) and methocarbamol (MT) by chemometric approaches and artificial neural networks using UV spectrophotometry has been reported as a simple alternative to using ..
  27. Erk N, Ozkan Y, Banoglu E, Ozkan S, Senturk Z. Simultaneous determination of paracetamol and methocarbamol in tablets by ratio spectra derivative spectrophotometry and LC. J Pharm Biomed Anal. 2001;24:469-75 pubmed
    ..and high-performance liquid chromatography (HPLC) to the simultaneous determination of paracetamol (PAR) and methocarbamol (MET) in combined pharmaceutical tablets is presented...
  28. Koupai Abyazani M, Esaw B, Laviolette B. Determination of methocarbamol in equine serum and urine by high-performance liquid chromatography with ultraviolet detection and atmospheric pressure ionization-mass spectrometric confirmation. J Anal Toxicol. 1997;21:301-5 pubmed
    Urine and serum samples collected from four standard-bred mares after and oral regimen administration of methocarbamol were extracted and analyzed...
  29. Schneider M. Pain reduction in breast augmentation using methocarbamol. Aesthetic Plast Surg. 1997;21:23-4 pubmed
    ..The standard use of narcotics alone does not optimize pain reduction. Methocarbamol was used intraoperatively and postoperatively in 62 patients undergoing manipulation of the pectoralis major ..
  30. Ferslew K, Hagardorn A, McCormick W. A fatal interaction of methocarbamol and ethanol in an accidental poisoning. J Forensic Sci. 1990;35:477-82 pubmed
    A case is presented of a fatal drug interaction caused by ingestion of methocarbamol (Robaxin) and ethanol. Methocarbamol is a carbamate derivative used as a muscle relaxant with sedative effects...