diethylcarbamazine

Summary

Summary: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Top Publications

  1. Casley Smith J, Jamal S, Casley Smith J. Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). Ann Trop Med Parasitol. 1993;87:247-58 pubmed
    ..It is cheap and of very low toxicity. Diethylcarbamazine (DEC) was studied with and without 56 BaP...
  2. Helmy H, Weil G, Ellethy A, Ahmed E, Setouhy M, Ramzy R. Bancroftian filariasis: effect of repeated treatment with diethylcarbamazine and albendazole on microfilaraemia, antigenaemia and antifilarial antibodies. Trans R Soc Trop Med Hyg. 2006;100:656-62 pubmed
    b>Diethylcarbamazine/albendazole (DEC/ALB) therapy is widely used in mass drug administration (MDA) programmes aimed at eliminating lymphatic filariasis...
  3. Bhumiratana A, Koyadun S, Srisuphanunt M, Satitvipawee P, Limpairojn N, Gaewchaiyo G. Border and imported bancroftian filariases: baseline seroprevalence in sentinel populations exposed to infections with Wuchereria bancrofti and concomitant HIV at the start of diethylcarbamazine mass treatment in Thailand. Southeast Asian J Trop Med Public Health. 2005;36:390-407 pubmed
    ..virus (HIV) immunoglobulins in the sentinel population samples which were studied prior to the start of the diethylcarbamazine (DEC) mass treatment phase in the PELF during fiscal years 2002-2006...
  4. Lima A, Medeiros Z, Santos Z, Costa G, Braga C. Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil. Rev Soc Bras Med Trop. 2012;45:745-50 pubmed
    ..This study assessed the occurrence of adverse drug reactions (ADRs) following the first round of mass treatment in two communities treated with different dosages of diethylcarbamazine (DEC) in the City of Recife, Brazil.
  5. Santos Rocha S, Silva B, Gomes F, Soares e Silva A, Raposo C, Barbosa K, et al. Effect of diethylcarbamazine on chronic hepatic inflammation induced by alcohol in C57BL/6 mice. Eur J Pharmacol. 2012;689:194-203 pubmed publisher
    Some pharmacological studies showed that diethylcarbamazine (DEC) interferes with the arachidonic acid metabolism, acting as an anti-inflammatory drug...
  6. Shakya S, Bajpai P, Sharma S, Misra Bhattacharya S. Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi. Parasitol Res. 2008;102:963-72 pubmed publisher
    ..therapy before antifilarial treatment to improve the filaricidal efficacy of the present-day filaricide diethylcarbamazine. An additional objective was to minimize host inflammatory reactions using a rodent model Mastomys coucha ..
  7. Dreyer G, Addiss D, Williamson J, Noroes J. Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti. Trans R Soc Trop Med Hyg. 2006;100:1118-25 pubmed
    Although diethylcarbamazine (DEC) and albendazole are recommended to interrupt transmission of Wuchereria bancrofti, little is known about the macrofilaricidal effect of this drug combination. Forty-seven men with W...
  8. Ramaiah K, Vijay Kumar K, Hosein E, Krishnamoorthy P, Augustin D, Snehalatha K, et al. A campaign of "communication for behavioural impact" to improve mass drug administrations against lymphatic filariasis: structure, implementation and impact on people's knowledge and treatment coverage. Ann Trop Med Parasitol. 2006;100:345-61 pubmed
    ..of many of those included in the rounds of MDA, so that they would be more likely to accept and consume the diethylcarbamazine tablets offered to them...
  9. Pal B, Kulkarni S, Bhandari Y, Ganesh B, Goswami K, Reddy M. Lymphatic filariasis: possible pathophysiological nexus with oxidative stress. Trans R Soc Trop Med Hyg. 2006;100:650-5 pubmed
    ..In the filarial cases, the levels of these parameters were assayed again after treatment with diethylcarbamazine citrate (DEC). Results showed significant (P<0...

More Information

Publications62

  1. Pani S, Reddy G, Vanamail P, Venkatesvarlou N, Das L, Vijayan A. Tolerability and efficacy of single dose diethylcarbamazine (DEC) alone or co-administration with Ivermectin in the clearance of Wuchereria bancrofti microfilaraemia in Pondicherry, South India. J Commun Dis. 2004;36:240-50 pubmed
    ..05). However, no significant difference was observed in reduction of geometric mean Mf density (99.9%, 99.7%, 99.5% respectively). In all the groups, the tolerability and efficacy of the drugs were independent of host age and gender...
  2. Meyrowitsch D, Simonsen P, Magesa S. Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment. Trans R Soc Trop Med Hyg. 2004;98:627-34 pubmed
    The long-term effect of three different strategies for mass diethylcarbamazine (DEC) administration in bancroftian filariasis was assessed 10 years after start of treatment in three endemic communities in Tanzania...
  3. De Rochars M, Direny A, Roberts J, Addiss D, Radday J, Beach M, et al. Community-wide reduction in prevalence and intensity of intestinal helminths as a collateral benefit of lymphatic filariasis elimination programs. Am J Trop Med Hyg. 2004;71:466-70 pubmed
    ..before and approximately nine months after each of two rounds of mass drug administration (MDA) with diethylcarbamazine and albendazole in the context of an LF elimination program in Leogane, Haiti...
  4. Horton J, Witt C, Ottesen E, Lazdins J, Addiss D, Awadzi K, et al. An analysis of the safety of the single dose, two drug regimens used in programmes to eliminate lymphatic filariasis. Parasitology. 2000;121 Suppl:S147-60 pubmed
    ..to be used in programmes to eliminate lymphatic filariasis (albendazole + ivermectin or albendazole + diethylcarbamazine [DEC]) is based on 17 studies conducted in Sri Lanka, India, Haiti, Ghana, Tanzania, Kenya, Ecuador, the ..
  5. Ramaiah K, Thiruvengadam B, Vanamail P, Subramanian S, Gunasekaran S, Nilamani N, et al. Prolonged persistence of residual Wuchereria bancrofti infection after cessation of diethylcarbamazine-fortified salt programme. Trop Med Int Health. 2009;14:870-6 pubmed publisher
    A diethylcarbamazine (DEC)-fortified salt intervention programme was implemented between 1982 and 1986 in Karaikal district, Union territory of Pondicherry, south India, to control Culex transmitted bancroftian filariasis...
  6. Ramaiah K. Lymphatic filariasis elimination programme in India: progress and challenges. Trends Parasitol. 2009;25:7-8 pubmed publisher
  7. Chadee D, Tilluckdharry C, Rawlins S, Doon R, Nathan M. Mass chemotherapy with diethylcarbamazine for the control of Bancroftian filariasis: a twelve-year follow-up in northern Trinidad, including observations on Mansonella ozzardi. Am J Trop Med Hyg. 1995;52:174-6 pubmed
    A microfilaria survey was conducted in Trinidad in 1992, 12 years after mass treatment with spaced doses of diethylcarbamazine citrate (DEC-C) for the control of Bancroftian filariasis; 348 persons were examined using thick blood smears ..
  8. Hussein O, El Setouhy M, Ahmed E, Kandil A, Ramzy R, Helmy H, et al. Duplex Doppler sonographic assessment of the effects of diethylcarbamazine and albendazole therapy on adult filarial worms and adjacent host tissues in Bancroftian filariasis. Am J Trop Med Hyg. 2004;71:471-7 pubmed
    We used duplex Doppler sonography to assess effects of diethylcarbamazine and albendazole therapy (DEC/ALB) on adult Wuchereria bancrofti in vivo...
  9. Sunish I, Rajendran R, Mani T, Munirathinam A, Reuben R, Dash A. Impact of single dose of diethylcarbamazine and other antifilarial drug combinations on bancroftian filarial infection variables: assessment after 2 years. Parasitol Int. 2006;55:233-6 pubmed
    The impact of single dose mass drug administration of diethylcarbamazine (DEC), DEC with albendazole (ALB), and ivermectin (IVR) with albendazole, was examined on the human bancroftian filarial infections in village scale trials in south ..
  10. Mataika J, Kimura E, Koroivueta J, Shimada M. Efficacy of five annual single doses of diethylcarbamazine for treatment of lymphatic filariasis in Fiji. Bull World Health Organ. 1998;76:575-9 pubmed
    Annual single-dose treatments with diethylcarbamazine citrate (DEC) at a dose of 6 mg/kg have been reported effective in reducing microfilariae (mf) rate and density and applicable to large-scale filariasis control campaigns...
  11. Joseph A, Mony P, Prasad M, John S, Srikanth -, Mathai D. The efficacies of affected-limb care with penicillin diethylcarbamazine, the combination of both drugs or antibiotic ointment, in the prevention of acute adenolymphangitis during bancroftian filariasis. Ann Trop Med Parasitol. 2004;98:685-96 pubmed
    ..subjects were supplied with tablets and ointment so that they could take oral penicillin (800 mg/day), oral diethylcarbamazine (DEC; 1 mg/kg...
  12. de Silva N, Pathmeswaran A, Fernando S, Weerasinghe C, Selvaratnam R, Padmasiri E, et al. Impact of mass chemotherapy for the control of filariasis on geohelminth infections in Sri Lanka. Ann Trop Med Parasitol. 2003;97:421-5 pubmed
  13. Simonsen P, Meyrowitsch D, Mukoko D, Pedersen E, Malecela Lazaro M, Rwegoshora R, et al. The effect of repeated half-yearly diethylcarbamazine mass treatment on Wuchereria bancrofti infection and transmission in two East African communities with different levels of endemicity. Am J Trop Med Hyg. 2004;70:63-71 pubmed
    The effect of repeated half-yearly mass treatment with diethylcarbamazine (DEC, 6 mg/kg body weight) on infection and transmission of Wuchereria bancrofti was assessed and compared in communities with high and low endemicity in eastern ..
  14. Fan P. Diethylcarbamazine treatment of bancroftian and malayan filariasis with emphasis on side effects. Ann Trop Med Parasitol. 1992;86:399-405 pubmed
    ..malayi, and in 84% of those with W. bancrofti. Overall, 63% of those treated were free of microfilariae on the last day of treatment, and 92% were free 48 months after treatment...
  15. Alves L, Brayner F, Silva L, Peixoto C. The ultrastructure of infective larvae (L3) of Wuchereria bancrofti after treatment with diethylcarbamazine. Micron. 2005;36:67-72 pubmed
    Although the large use of diethylcarbamazine (DEC), as the major anti-filaricide drug, its mechanism of action remains a matter of controversy. Several authors defend the hypothesis that DEC has no direct effect on nematodes...
  16. Ottesen E, Duke B, Karam M, Behbehani K. Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ. 1997;75:491-503 pubmed
    ..Annual single-dose co-administration of two drugs (ivermectin + diethylcarbamazine (DEC) or albendazole) reduces blood microfilariae by 99% for a full year; even a single dose of one drug (..
  17. Fox L, Furness B, Haser J, Desire D, Brissau J, Milord M, et al. Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. Am J Trop Med Hyg. 2005;73:115-21 pubmed
    ..Children were randomly assigned treatment with placebo, albendazole (ALB), diethylcarbamazine (DEC), or combined therapy...
  18. Saraiva K, Silva V, Torres D, Donato M, Peres N, Souza J, et al. Changes in mouse Leydig cells ultrastructure and testosterone secretion after diethylcarbamazine administration. Micron. 2008;39:580-6 pubmed
    b>Diethylcarbamazine (DEC) has been proven to be highly effective against lymphatic filariasis, although its effect on vertebrate cells remains uncertain...
  19. Ismail M, Jayakody R. Efficacy of albendazole and its combinations with ivermectin or diethylcarbamazine (DEC) in the treatment of Trichuris trichiura infections in Sri Lanka. Ann Trop Med Parasitol. 1999;93:501-4 pubmed
    ..Single-dose combinations of albendazole with ivermectin or of albendazole with diethylcarbamazine (DEC) have recently been seen to produce raid and sustained reductions in Wuchereria bancrofti ..
  20. McLaughlin S, Radday J, Michel M, Addiss D, Beach M, Lammie P, et al. Frequency, severity, and costs of adverse reactions following mass treatment for lymphatic filariasis using diethylcarbamazine and albendazole in Leogane, Haiti, 2000. Am J Trop Med Hyg. 2003;68:568-73 pubmed
    In October 2000, 71,187 persons were treated for lymphatic filariasis using albendazole and diethylcarbamazine (DEC) or DEC alone in Leogane, Haiti. We documented the frequency of adverse reactions, severity and cost of treatment...
  21. Babu B, Satyanarayana K. Factors responsible for coverage and compliance in mass drug administration during the programme to eliminate lymphatic filariasis in the East Godavari District, South India. Trop Doct. 2003;33:79-82 pubmed
    The paper attempts to report the factors responsible for the coverage and compliance of mass diethylcarbamazine citrate (DEC) administration, during the programme to eliminate lymphatic filariasis in the East Godavari District of Andhra ..
  22. Rajendran R, Sunish I, Mani T, Munirathinam A, Abdullah S, Augustin D, et al. The influence of the mass administration of diethylcarbamazine, alone or with albendazole, on the prevalence of filarial antigenaemia. Ann Trop Med Parasitol. 2002;96:595-602 pubmed
    ..e. revenue units) of Villupuram district, in Tamil Nadu, India, were treated with diethylcarbamazine (DEC), either alone (Mugaiyur) or with albendazole (Tirukoilur), in March 2001...
  23. Bockarie M, Tavul L, Ibam I, Kastens W, Hazlett F, Tisch D, et al. Efficacy of single-dose diethylcarbamazine compared with diethylcarbamazine combined with albendazole against Wuchereria bancrofti infection in Papua New Guinea. Am J Trop Med Hyg. 2007;76:62-6 pubmed
    The efficacy of diethylcarbamazine alone was compared with diethylcarbamazine plus albendazole in residents of an island in Papua New Guinea endemic for Wuchereria bancrofti...
  24. Ramaiah K, Vijay Kumar K, Chandrakala A, Augustin D, Appavoo N, Das P. Effectiveness of community and health services-organized drug delivery strategies for elimination of lymphatic filariasis in rural areas of Tamil Nadu, India. Trop Med Int Health. 2001;6:1062-9 pubmed
    ..This requires an effective and sustainable strategy to deliver the drug, diethylcarbamazine (DEC), to communities...
  25. Ramaiah K, Das P, Vanamail P, Pani S. Impact of 10 years of diethylcarbamazine and ivermectin mass administration on infection and transmission of lymphatic filariasis. Trans R Soc Trop Med Hyg. 2007;101:555-63 pubmed
    The potential of repeated mass administration of diethylcarbamazine (DEC) and ivermectin to eliminate lymphatic filariasis has been examined in a study implemented in 10 villages with a population of 18415 in south India...
  26. Freedman D, Plier D, de Almeida A, de Oliveira A, Miranda J, Braga C. Effect of aggressive prolonged diethylcarbamazine therapy on circulating antigen levels in bancroftian filariasis. Trop Med Int Health. 2001;6:37-41 pubmed
    Single dose diethylcarbamazine (DEC) as used in control programmes is effectively microfilaricidal for periods of up to a year or more but has incomplete ability to kill Wuchereria bancrofti adult parasites...
  27. Stolk W, van Oortmarssen G, Pani S, de Vlas S, Subramanian S, Das P, et al. Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis. Am J Trop Med Hyg. 2005;73:881-7 pubmed
    Ivermectin and diethylcarbamazine (DEC) are used in mass treatment programs for the elimination of lymphatic filariasis because of their strong effects on microfilaremia...
  28. Yuvaraj J, Pani S, Vanamail P, Ramaiah K, Das P. Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India. Trop Med Int Health. 2008;13:737-42 pubmed publisher
    To evaluate the impact of seven rounds of mass administration of diethylcarbamazine (DEC) and ivermectin on the prevalence of chronic lymphatic filariasis and to compare it with that observed in a placebo arm in a community-level trial.
  29. Supali T, Djuardi Y, Pfarr K, Wibowo H, Taylor M, Hoerauf A, et al. Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin Infect Dis. 2008;46:1385-93 pubmed publisher
    ..Standard treatment with diethylcarbamazine-albendazole is associated with adverse reactions...
  30. Peixoto C, Rocha A, Aguiar Santos A, Florêncio M. The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti in vivo and in vitro. Parasitol Res. 2004;92:513-7 pubmed
    ..study of microfilariae of Wuchereria bancrofti was performed after treatment in vitro and in vivo with diethylcarbamazine citrate (DEC)...
  31. Ramaiah K, Vanamail P, Pani S, Yuvaraj J, Das P. The effect of six rounds of single dose mass treatment with diethylcarbamazine or ivermectin on Wuchereria bancrofti infection and its implications for lymphatic filariasis elimination. Trop Med Int Health. 2002;7:767-74 pubmed
    Annual mass treatment with single-dose diethylcarbamazine (DEC) or ivermectin (IVM) in combination with albendazole (ALB) for 4-6 years is the principal tool of lymphatic filariasis (LF) elimination strategy...
  32. Njenga S, Wamae C, Njomo D, Mwandawiro C, Molyneux D. Impact of two rounds of mass treatment with diethylcarbamazine plus albendazole on Wuchereria bancrofti infection and the sensitivity of immunochromatographic test in Malindi, Kenya. Trans R Soc Trop Med Hyg. 2008;102:1017-24 pubmed publisher
    Annual single-dose mass treatment of endemic populations with a combination of either diethylcarbamazine (DEC) or ivermectin plus albendazole is recommended as the mainstay of lymphatic filariasis elimination programmes...
  33. Tisch D, Bockarie M, Dimber Z, Kiniboro B, Tarongka N, Hazlett F, et al. Mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea: changes in microfilaremia, filarial antigen, and Bm14 antibody after cessation. Am J Trop Med Hyg. 2008;78:289-93 pubmed
    ..These data suggest that Bm14 antibody may be a sensitive test to monitor continuing transmission during and after mass drug administration aimed at eliminating transmission of lymphatic filariasis...
  34. Kimura E, Spears G, Singh K, Samarawickrema W, Penaia L, Sone P, et al. Long-term efficacy of single-dose mass treatment with diethylcarbamazine citrate against diurnally subperiodic Wuchereria bancrofti: eight years' experience in Samoa. Bull World Health Organ. 1992;70:769-76 pubmed
    A single-dose of diethylcarbamazine citrate (DEC, 6 mg per kg body weight) was administered in three mass treatment campaigns to > 80% of the estimated total Samoan population (160,000) in 1982, 1983, and 1986...
  35. Ozoh G, Boussinesq M, Bissek A, Kobangue L, Kombila M, Mbina J, et al. Evaluation of the diethylcarbamazine patch to evaluate onchocerciasis endemicity in Central Africa. Trop Med Int Health. 2007;12:123-9 pubmed
    As part of a baseline data collection for assessing the impact of the African Programme for Onchocerciasis Control, to evaluate the diethylcarbamazine (DEC) patch test in determining the endemicity of onchocerciasis.
  36. Krentel A, Fischer P, Manoempil P, Supali T, Servais G, Ruckert P. Using knowledge, attitudes and practice (KAP) surveys on lymphatic filariasis to prepare a health promotion campaign for mass drug administration in Alor District, Indonesia. Trop Med Int Health. 2006;11:1731-40 pubmed
    ..The first KAP survey was conducted as a baseline pre-MDA with diethylcarbamazine and albendazole and the second as a post-intervention evaluation in order to obtain information on the ..
  37. Schwab A, Churcher T, Schwab A, Basáñez M, Prichard R. Population genetics of concurrent selection with albendazole and ivermectin or diethylcarbamazine on the possible spread of albendazole resistance in Wuchereria bancrofti. Parasitology. 2006;133:589-601 pubmed
    ..to achieve its aims through yearly mass treatments with albendazole (ABZ) combined with ivermectin (IVM) or diethylcarbamazine (DEC)...
  38. Shenoy R, Kumaraswami V, Suma T, Rajan K, Radhakuttyamma G. A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis. Ann Trop Med Parasitol. 1999;93:367-77 pubmed
    ..Such cases are now being treated with multiple courses of the antifilarial drug diethylcarbamazine (DEC), either alone or in combination with antibiotics or anti-inflammatory drugs, based on anecdotal ..
  39. Koyadun S, Bhumiratana A. Surveillance of imported bancroftian filariasis after two-year multiple-dose diethylcarbamazine treatment. Southeast Asian J Trop Med Public Health. 2005;36:822-31 pubmed
    ..They have a significant influence on the effectiveness of diethylcarbamazine (DEC) mass treatment at the provincial level in the National Program to Eliminate Lymphatic Filariasis (PELF)..
  40. Kshirsagar N, Gogtay N, Garg B, Deshmukh P, Rajgor D, Kadam V, et al. Safety, tolerability, efficacy and plasma concentrations of diethylcarbamazine and albendazole co-administration in a field study in an area endemic for lymphatic filariasis in India. Trans R Soc Trop Med Hyg. 2004;98:205-17 pubmed
    ..Using a combination, such as albendazole (ALB) to diethylcarbamazine (DEC) gives both macrofilaricidal and anti-helmintic activity...
  41. Freeman A, Lammie P, Houston R, LaPointe M, Streit T, Jooste P, et al. A community-based trial for the control of lymphatic filariasis and iodine deficiency using salt fortified with diethylcarbamazine and iodine. Am J Trop Med Hyg. 2001;65:865-71 pubmed
    To evaluate the effectiveness of salt fortified with diethylcarbamazine (DEC) and iodine for elimination of Bancroftian filariasis and iodine deficiency, all consenting residents of Miton, Haiti (n = 1,932) were given salt fortified with ..
  42. Shenoy R, John A, Babu B, Suma T, Kumaraswami V. Two-year follow-up of the microfilaraemia of asymptomatic brugian filariasis, after treatment with two, annual, single doses of ivermectin, diethylcarbamazine and albendazole, in various combinations. Ann Trop Med Parasitol. 2000;94:607-14 pubmed
    Repeated, single, oral doses of combinations of ivermectin, diethylcarbamazine (DEC) or albendazole are recognized as important tools for parasite control in lymphatic filariasis...
  43. Albiez E, Walter G, Kaiser A, Newland H, White A, Greene B, et al. Effects of high doses of diethylcarbamazine on adult Onchocerca volvulus examined by the collagenase technique and by histology. Trop Med Parasitol. 1988;39:87-92 pubmed
    ..carriers from a hyperendemic onchocerciasis area in the Liberian rain forest were treated with high doses of diethylcarbamazine (30 mg/kg/d) over one week. Another ten patients received placebo tablets and served as a control...
  44. Moss D, Priest J, Boyd A, Weinkopff T, Kucerova Z, Beach M, et al. Multiplex bead assay for serum samples from children in Haiti enrolled in a drug study for the treatment of lymphatic filariasis. Am J Trop Med Hyg. 2011;85:229-37 pubmed publisher
    ..IgG responses to PTP3 and MSP-1(19) were not affected by albendazole (ALB), diethylcarbamazine (DEC), or combination of diethylcarbamazine and albendazole (DEC/ALB)...
  45. Queto T, Xavier Elsas P, Gardel M, de Luca B, Barradas M, Masid D, et al. Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine. Am J Respir Crit Care Med. 2010;181:429-37 pubmed publisher
    The mechanism of action of diethylcarbamazine (DEC), an antifilarial drug effective against tropical pulmonary eosinophilia, remains controversial. DEC effects on microfilariae depend on inducible NO synthase (iNOS)...
  46. Mand S, Pfarr K, Sahoo P, Satapathy A, Specht S, Klarmann U, et al. Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am J Trop Med Hyg. 2009;81:702-11 pubmed publisher
    ..controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4 months post treatment) on depletion of Wolbachia endobacteria from Wuchereria bancrofti, ..
  47. Das P, Ramaiah K, Vanamail P, Pani S, Yuvaraj J, Balarajan K, et al. Placebo-controlled community trial of four cycles of single-dose diethylcarbamazine or ivermectin against Wuchereria bancrofti infection and transmission in India. Trans R Soc Trop Med Hyg. 2001;95:336-41 pubmed
    ..placebo-controlled trial was carried out in 1994-98 to compare the effects of 4 cycles of single-dose diethylcarbamazine (DEC) or ivermectin on prevalence and geometric mean intensity (GMI) of microfilaraemia in the human ..
  48. Bernhard P, Magnussen P, Lemnge M. A randomized, double-blind, placebo-controlled study with diethylcarbamazine for the treatment of hydrocoele in an area of Tanzania endemic for lymphatic filariasis. Trans R Soc Trop Med Hyg. 2001;95:534-6 pubmed
    ..Two community studies have recently suggested that the antifilarial drug diethylcarbamazine (DEC) may have a beneficial effect of reducing the size of hydrocoeles of filarial origin...
  49. Gunawardena N, Amarasekera N, Pathmeswaran A, de Silva N. Effect of repeated mass chemotherapy for filariasis control on soil-transmitted helminth infections in Sri Lanka. Ceylon Med J. 2008;53:13-6 pubmed
    In July 2006 Sri Lanka completed 5 rounds of annual mass drug administration (MDA) with diethylcarbamazine citrate (DEC) and albendazole as part of its national programme for elimination of lymphatic filariasis (LF)...
  50. Rajendran R, Sunish I, Mani T, Munirathinam A, Abdullah S, Arunachalam N, et al. Impact of two annual single-dose mass drug administrations with diethylcarbamazine alone or in combination with albendazole on Wuchereria bancrofti microfilaraemia and antigenaemia in south India. Trans R Soc Trop Med Hyg. 2004;98:174-81 pubmed
    ..out in Tamil Nadu state, India to assess the effect of 2 annual single-dose mass drug administrations of diethylcarbamazine + albendazole (DEC + ALB) on microfilaraemia and antigenaemia in one arm, and diethylcarbamazine(DEC) alone ..
  51. Simonsen P, Magesa S, Meyrowitsch D, Malecela Lazaro M, Rwegoshora R, Jaoko W, et al. The effect of eight half-yearly single-dose treatments with DEC on Wuchereria bancrofti circulating antigenaemia. Trans R Soc Trop Med Hyg. 2005;99:541-7 pubmed
    The effect of eight half-yearly treatment rounds with diethylcarbamazine (DEC; 6mg/kg bodyweight) on Wuchereria bancrofti-specific circulating filarial antigen (CFA), a marker of adult worm infection, was followed in 79 individuals who ..
  52. Gunawardena N, Fujimaki Y, Aoki Y, Mishima N, Ezaki T, Uni S, et al. Differential effects of diethylcarbamazine, tetracycline and the combination on Brugia pahangi adult females in vitro. Parasitol Int. 2005;54:253-9 pubmed
    Anti-filarial effects of diethylcarbamazine (DEC), tetracycline (TC) and the combination on Brugia pahangi adult females were studied in 7-day cell-free culture, in terms of microfilaria release, parasite motility, MTT assay for parasite ..
  53. Saraiva K, Silva V, Dias E, Peixoto C. Morphological changes in the testis induced by diethylcarbamazine. Reprod Toxicol. 2006;22:754-9 pubmed
    b>Diethylcarbamazine (DEC) had been proved to be highly effective against lymphatic filariasis, however its effect on vertebrate cells remains uncertain...