acrylamide

Summary

Summary: A colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile. It is primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries.

Top Publications

  1. Whittaker A, Marotti I, Dinelli G, Calamai L, Romagnoli S, Manzelli M, et al. The influence of tuber mineral element composition as a function of geographical location on acrylamide formation in different Italian potato genotypes. J Sci Food Agric. 2010;90:1968-76 pubmed publisher
    ..examining the effect of tuber mineral composition, distinctive for geographical location, on the expression of acrylamide precursors in three potato genotypes (Arinda, Rossa di Cetica and Sieglinde) in three Italian potato cultivation ..
  2. Catalgol B, Ozhan G, Alpertunga B. Acrylamide-induced oxidative stress in human erythrocytes. Hum Exp Toxicol. 2009;28:611-7 pubmed publisher
    b>Acrylamide (AA), a widely used industrial chemical, is shown to be neurotoxic, mutagenic and carcinogenic...
  3. Pedersen M, von Stedingk H, Botsivali M, Agramunt S, Alexander J, Brunborg G, et al. Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environ Health Perspect. 2012;120:1739-45 pubmed publisher
    b>Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents.
  4. Ahmad E, Fatima S, Khan M, Khan R. More stable structure of wheat germ lipase at low pH than its native state. Biochimie. 2010;92:885-93 pubmed publisher
    ..Although enzymatically inactive, acid-induced state at pH 0.8 was found to be structurally more stable than native lipase, as shown by chemical and thermal denaturation profiles...
  5. Arihan O, Seringeç N, Gürel E, Dikmenoğlu N. Effects of oral acrylamide intake on blood viscosity parameters in rats. Clin Hemorheol Microcirc. 2011;47:45-52 pubmed publisher
    b>Acrylamide which is formed via reaction of reducing sugars with amino acids during food processing at high temperatures is not only neurotoxic and carcinogenic, but it also damages erythrocyte membrane and generates micronucleated ..
  6. Martyniuk C, Fang B, Koomen J, Gavin T, Zhang L, Barber D, et al. Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by ?,?-unsaturated carbonyl derivatives. Chem Res Toxicol. 2011;24:2302-11 pubmed publisher
    ..To address these data gaps, we incubated purified human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with acrylamide (ACR), acrolein, or methylvinyl ketone (MVK)...
  7. Duarte Salles T, von Stedingk H, Granum B, Gutzkow K, Rydberg P, Törnqvist M, et al. Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa). Environ Health Perspect. 2013;121:374-9 pubmed publisher
    b>Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures...
  8. LoPachin R, Gavin T. Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry. Environ Health Perspect. 2012;120:1650-7 pubmed publisher
    b>Acrylamide (ACR) produces cumulative neurotoxicity in exposed humans and laboratory animals through a direct inhibitory effect on presynaptic function.
  9. Parker J, Balagiannis D, Higley J, Smith G, Wedzicha B, Mottram D. Kinetic model for the formation of acrylamide during the finish-frying of commercial french fries. J Agric Food Chem. 2012;60:9321-31 pubmed publisher
    b>Acrylamide is formed from reducing sugars and asparagine during the preparation of French fries...

More Information

Publications62

  1. Mojska H, Gielecińska I, Stos K. Determination of acrylamide level in commercial baby foods and an assessment of infant dietary exposure. Food Chem Toxicol. 2012;50:2722-8 pubmed publisher
    b>Acrylamide is a monomer that can form in heated starchy food as a result of Maillard reaction. The adverse effects of acrylamide in humans are neurotoxicity and carcinogenicity...
  2. Mei N, McDaniel L, Dobrovolsky V, Guo X, Shaddock J, Mittelstaedt R, et al. The genotoxicity of acrylamide and glycidamide in big blue rats. Toxicol Sci. 2010;115:412-21 pubmed publisher
    b>Acrylamide (AA), a mutagen and rodent carcinogen, recently has been detected in fried and baked starchy foods, a finding that has prompted renewed interest in its potential for toxicity in humans...
  3. Huang Y, Wu K, Liou S, Uang S, Chen C, Shih W, et al. Biological monitoring for occupational acrylamide exposure from acrylamide production workers. Int Arch Occup Environ Health. 2011;84:303-13 pubmed publisher
    ..a repeated-measurement study to (1) investigate the correlation between occupational exposure to airborne acrylamide (AA) and the time-dependent behavior of urinary AAMA, GAMA2, and GAMA3 and (2) calculate the estimated ..
  4. Lipworth L, Sonderman J, Tarone R, McLaughlin J. Review of epidemiologic studies of dietary acrylamide intake and the risk of cancer. Eur J Cancer Prev. 2012;21:375-86 pubmed publisher
    Conjectured associations between dietary acrylamide intake and cancer have been evaluated in more than 15 epidemiologic studies examining almost every major cancer site...
  5. Vikström A, Warholm M, Paulsson B, Axmon A, Wirfalt E, Törnqvist M. Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire data. Food Chem Toxicol. 2012;50:2531-9 pubmed publisher
    Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food...
  6. Pernice R, Hauder J, Koehler P, Vitaglione P, Fogliano V, Somoza V. Effect of sulforaphane on glutathione-adduct formation and on glutathione_S_transferase-dependent detoxification of acrylamide in Caco-2 cells. Mol Nutr Food Res. 2009;53:1540-50 pubmed publisher
    The toxicity of dietary acrylamide (AA) depends on its biotransformation pathways, in which phase I cytochrome P-450 enzymes transform AA into glycidamide...
  7. Muttucumaru N, Powers S, Elmore J, Mottram D, Halford N. Effects of nitrogen and sulfur fertilization on free amino acids, sugars, and acrylamide-forming potential in potato. J Agric Food Chem. 2013;61:6734-42 pubmed publisher
    ..in the formation of color, aroma, and flavor compounds, but also some undesirable contaminants, including acrylamide, which forms when the amino acid that participates in the final stages of the reaction is asparagine...
  8. Ghanayem B, Bai R, Kissling G, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 2010;82:96-104 pubmed publisher
    ..2, 1.6, and 7.2-fold, respectively. The fertility of male mice was compared through mating with control females. Acrylamide (AA)-induced reproductive toxicity was assessed in obese or lean males treated with water or 25 mg AA kg(-1) day(..
  9. Stølevik S, Nygaard U, Namork E, Haugen M, Kvalem H, Meltzer H, et al. Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem Toxicol. 2011;49:1843-8 pubmed publisher
    ..We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment...
  10. Ewaleifoh O, Trinh M, Griffin J, Nguyen T. A novel system to accelerate the progression of nerve degeneration in transgenic mouse models of neuropathies. Exp Neurol. 2012;237:153-9 pubmed publisher
    ..Here, we present a novel technique using acrylamide, an axonal neurotoxin, to provoke rapid axonal degeneration in murine models of neuropathies...
  11. Lee T, Manjanatha M, Aidoo A, Moland C, Branham W, Fuscoe J, et al. Expression analysis of hepatic mitochondria-related genes in mice exposed to acrylamide and glycidamide. J Toxicol Environ Health A. 2012;75:324-39 pubmed publisher
    b>Acrylamide (AA) is an industrial chemical that has been extensively investigated for central nervous system (CNS), reproductive, and genetic toxicity...
  12. Wilson K, Giovannucci E, Stampfer M, Mucci L. Dietary acrylamide and risk of prostate cancer. Int J Cancer. 2012;131:479-87 pubmed publisher
    b>Acrylamide has been designated by IARC as a "probable human carcinogen." High levels are formed during cooking of many commonly consumed foods including French fries, potato chips, breakfast cereal and coffee...
  13. Hogervorst J, Baars B, Schouten L, Konings E, Goldbohm R, van den Brandt P. The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol. 2010;40:485-512 pubmed publisher
    Since 2002, it is known that the probable human carcinogen acrylamide is present in commonly consumed carbohydrate-rich foods, such as French fries and potato chips...
  14. Tran N, Barraj L, Murphy M, Bi X. Dietary acrylamide exposure and hemoglobin adducts--National Health and Nutrition Examination Survey (2003-04). Food Chem Toxicol. 2010;48:3098-108 pubmed publisher
    ..Measured acrylamide (AA-Hb) and glycidamide (Gly-Hb) hemoglobin adducts for over 7000 participants >3 years, 24-h dietary recall, ..
  15. Prasad S, Muralidhara -. Evidence of acrylamide induced oxidative stress and neurotoxicity in Drosophila melanogaster - its amelioration with spice active enrichment: relevance to neuropathy. Neurotoxicology. 2012;33:1254-64 pubmed publisher
    b>Acrylamide (ACR) intoxication in its monomeric form leads to neuronal damage in both experimental animals and humans. Oxidative stress is one of the principle mechanisms related to the neurotoxicity of ACR exposure...
  16. Rodríguez Ramiro I, Ramos S, Bravo L, Goya L, Martin M. Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. J Nutr Biochem. 2011;22:1186-94 pubmed publisher
    Humans are exposed to dietary acrylamide (AA) during their lifetime; it is therefore necessary to investigate the mechanisms associated with AA induced toxic effects...
  17. Nixon B, Stanger S, Nixon B, Roman S. Chronic exposure to acrylamide induces DNA damage in male germ cells of mice. Toxicol Sci. 2012;129:135-45 pubmed publisher
    b>Acrylamide is a reproductive toxicant that has been detected in foods such as potato chips and breads...
  18. Olsen A, Christensen J, Outzen M, Olesen P, Frandsen H, Overvad K, et al. Pre-diagnostic acrylamide exposure and survival after breast cancer among postmenopausal Danish women. Toxicology. 2012;296:67-72 pubmed publisher
    b>Acrylamide is a probable human carcinogen, with industrial contact, tobacco smoking and foods processed at high temperatures as the main routes of exposure...
  19. Von Tungeln L, Doerge D, Gamboa da Costa G, Matilde Marques M, Witt W, Koturbash I, et al. Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay. Int J Cancer. 2012;131:2008-15 pubmed publisher
    b>Acrylamide is a high-volume industrial chemical, a component of cigarette smoke, and a product formed in certain foods prepared at high temperatures...
  20. Vikström A, Abramsson Zetterberg L, Naruszewicz M, Athanassiadis I, Granath F, Törnqvist M. In vivo doses of acrylamide and glycidamide in humans after intake of acrylamide-rich food. Toxicol Sci. 2011;119:41-9 pubmed publisher
    For assessment of cancer risk from acrylamide (AA) exposure through food, the relation between intake from food in humans and the in vivo doses (area under the concentration-time curve, AUC) of AA (AUC-AA) and of its genotoxic metabolite ..
  21. Lee Y, Wu B, Raymond J, Zeng Y, Fang X, Wooley K, et al. A genetically encoded acrylamide functionality. ACS Chem Biol. 2013;8:1664-70 pubmed publisher
    ..The acrylamide moiety is stable in cells, whereas it is active enough to perform a diverse set of unique reactions for protein ..
  22. Curtis T, Powers S, Balagiannis D, Elmore J, Mottram D, Parry M, et al. Free amino acids and sugars in rye grain: implications for acrylamide formation. J Agric Food Chem. 2010;58:1959-69 pubmed publisher
    b>Acrylamide forms from free asparagine and sugars during cooking, and products derived from the grain of cereals, including rye, contribute a large proportion of total dietary intake...
  23. Konings E, Hogervorst J, Van Rooij L, Schouten L, Sizoo E, Van Egmond H, et al. Validation of a database on acrylamide for use in epidemiological studies. Eur J Clin Nutr. 2010;64:534-40 pubmed publisher
    b>Acrylamide, a probable human carcinogen, was detected in various heat-treated foods such as French fries and potato crisps...
  24. Kelkar D, Chaudhuri A, Haldar S, Chattopadhyay A. Exploring tryptophan dynamics in acid-induced molten globule state of bovine alpha-lactalbumin: a wavelength-selective fluorescence approach. Eur Biophys J. 2010;39:1453-63 pubmed publisher
    ..Quenching of BLA tryptophan fluorescence using quenchers of varying polarity (acrylamide and trichloroethanol) reveals varying degrees of accessibility of tryptophan residues, characteristic of native ..
  25. Camacho L, Latendresse J, Muskhelishvili L, Patton R, Bowyer J, Thomas M, et al. Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats. Toxicol Lett. 2012;211:135-43 pubmed publisher
    b>Acrylamide (AA) is a reactive monomer used in many technological applications, but it is the incidental formation during cooking of common starchy foods that leads to pervasive human exposure, typically in the range of 1 ?g/kg body weight ..
  26. Ahmed H, Elmegeed G, El Sayed E, Abd Elhalim M, Shousha W, Shafic R. Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats. Eur J Med Chem. 2010;45:5452-9 pubmed publisher
    b>Acrylamide (ACR) has been shown to be a neurotoxic agent for both laboratory animals and human...
  27. Mehri S, Abnous K, Mousavi S, Shariaty V, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012;32:227-35 pubmed publisher
    b>Acrylamide (ACR) is a potent neurotoxic in human and animal models. In this study, the effect of crocin, main constituent of Crocus sativus L...
  28. Lin C, Lee H, Chen Y, Lien G, Lin L, Wen L, et al. Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. J Hazard Mater. 2013;261:372-7 pubmed publisher
    b>Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans...
  29. Normandin L, Bouchard M, Ayotte P, Blanchet C, Becalski A, Bonvalot Y, et al. Dietary exposure to acrylamide in adolescents from a Canadian urban center. Food Chem Toxicol. 2013;57:75-83 pubmed publisher
    The distribution of acrylamide in food items frequently consumed by Canadian adolescents was determined along with estimates of their contribution to the overall dietary intake of acrylamide...
  30. Tardiff R, Gargas M, Kirman C, Carson M, Sweeney L. Estimation of safe dietary intake levels of acrylamide for humans. Food Chem Toxicol. 2010;48:658-67 pubmed publisher
    b>Acrylamide (AA), a human neurotoxicant and rat tumorigen, is produced in starchy foods when cooked. AA is also an industrial chemical used in polyacrylamide production...
  31. Blom S, Schmitt N, Jensen H. The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes. PLoS ONE. 2009;4:e8251 pubmed publisher
  32. El Sayyad H, Abou Egla M, El Sayyad F, El Ghawet H, Gaur R, Fernando A, et al. Effects of fried potato chip supplementation on mouse pregnancy and fetal development. Nutrition. 2011;27:343-50 pubmed publisher
    b>Acrylamide (ACR), a proven rodent carcinogen, is present at significantly high quantities in commonly consumed foods such as potato chips, raising a health concern worldwide.
  33. Shi J, Ma Y, Zheng M, Ruan Z, Liu J, Tian S, et al. Effect of sub-acute exposure to acrylamide on GABAergic neurons and astrocytes in weaning rat cerebellum. Toxicol Ind Health. 2012;28:10-20 pubmed publisher
    Occupational exposure and experimental intoxication of acrylamide (ACR) can produce skeletal muscle weakness and ataxia...
  34. Zhang L, Gavin T, Barber D, LoPachin R. Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Toxicol Lett. 2011;205:1-7 pubmed publisher
    b>Acrylamide (ACR) intoxication is associated with selective nerve terminal damage in the central and peripheral nervous systems...
  35. Erkekoglu P, Baydar T. Toxicity of acrylamide and evaluation of its exposure in baby foods. Nutr Res Rev. 2010;23:323-33 pubmed publisher
    ..b>Acrylamide, an ?,?-unsaturated (conjugated) reactive molecule, can be detected as a contaminant in several foodstuffs ..
  36. Halford N, Curtis T, Muttucumaru N, Postles J, Elmore J, Mottram D. The acrylamide problem: a plant and agronomic science issue. J Exp Bot. 2012;63:2841-51 pubmed publisher
    b>Acrylamide, a chemical that is probably carcinogenic in humans and has neurological and reproductive effects, forms from free asparagine and reducing sugars during high-temperature cooking and processing of common foods...
  37. Bowyer J, Latendresse J, Delongchamp R, Warbritton A, Thomas M, Divine B, et al. The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water. Toxicol Appl Pharmacol. 2009;240:401-11 pubmed publisher
    ..expression or overt histological signs of neurotoxicity in selected regions of the forebrain might occur from acrylamide exposure via drinking water...
  38. Huang Y, Chen M, Liou S, Chen M, Uang S, Wu K. Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide. Toxicol Lett. 2011;203:118-26 pubmed publisher
    This study elucidates the association of acrylamide metabolites, N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA), N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-cysteine (GAMA2), and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-cysteine (GAMA3) in ..
  39. Hirvonen T, Kontto J, Jestoi M, Valsta L, Peltonen K, Pietinen P, et al. Dietary acrylamide intake and the risk of cancer among Finnish male smokers. Cancer Causes Control. 2010;21:2223-9 pubmed publisher
    To assess the association between dietary acrylamide intake and the risk of cancer among male smokers. The study consisted of 27,111 male smokers, aged 50-69 years, without history of cancer...
  40. Chawla R, Shakya R, Rommens C. Tuber-specific silencing of asparagine synthetase-1 reduces the acrylamide-forming potential of potatoes grown in the field without affecting tuber shape and yield. Plant Biotechnol J. 2012;10:913-24 pubmed publisher
    ..of asparagine synthetase (Ast)-1 and -2 limits asparagine (ASN) formation and, consequently, reduces the acrylamide-forming potential of tubers...
  41. Pelucchi C, La Vecchia C, Bosetti C, Boyle P, Boffetta P. Exposure to acrylamide and human cancer--a review and meta-analysis of epidemiologic studies. Ann Oncol. 2011;22:1487-99 pubmed publisher
    b>Acrylamide has been associated to cancer risk in rodents, but data on humans are inconclusive. We thus carried out a critical review and meta-analysis of studies of exposure to acrylamide and cancer.
  42. Raju J, Sondagar C, Roberts J, Aziz S, Caldwell D, Vavasour E, et al. Dietary acrylamide does not increase colon aberrant crypt foci formation in male F344 rats. Food Chem Toxicol. 2011;49:1373-80 pubmed publisher
    b>Acrylamide, a known rodent and a probable human carcinogen, is spontaneously formed in foods cooked at high temperature...
  43. Garey J, Paule M. Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats. Neurotoxicol Teratol. 2010;32:220-5 pubmed publisher
    b>Acrylamide (ACR) is a relatively potent neurotoxicant. The ingestion of carbohydrate-containing foods cooked at high temperature exposes humans to low levels of ACR virtually daily. At relatively high levels of exposure (i.e...
  44. Zhu G, Zheng H, Zhang P, Jiao Z, Yin J. Near-infrared spectroscopy as a potential tool with radial basis function for measurement of residual acrylamide in organic polymer. Environ Technol. 2013;34:91-9 pubmed
    Poly(acrylamide-co-diallyldimethylammonium chloride) (PDA), which is usually prepared by free radical polymerization of acrylamide monomer (AM) onto the cationic monomer dimethyl diallyl ammonium chloride (DMDAAC), has been widely applied ..
  45. Song J, Zhao M, Liu X, Zhu Y, Hu X, Chen F. Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells. Food Chem Toxicol. 2013;58:306-10 pubmed publisher
    b>Acrylamide (AA) occurs in many cooked starchy foods and has caused widespread concern as a possible carcinogen...
  46. Rahim M, Syed M, Shukor M. Isolation and characterization of an acrylamide-degrading yeast Rhodotorula sp. strain MBH23 KCTC 11960BP. J Basic Microbiol. 2012;52:573-81 pubmed publisher
    As well as for chemical and environmental reasons, acrylamide is widely used in many industrial applications. Due to its carcinogenicity and toxicity, its discharge into the environment causes adverse effects on humans and ecology alike...
  47. Zhang L, Wang E, Chen F, Yan H, Yuan Y. Potential protective effects of oral administration of allicin on acrylamide-induced toxicity in male mice. Food Funct. 2013;4:1229-36 pubmed publisher
    b>Acrylamide (AA) forms during the heating of starchy foods at high temperature, and is regarded as a potential genotoxic carcinogen...
  48. Alturfan A, Tozan Beceren A, Sehirli A, Demiralp E, Sener G, Omurtag G. Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Mol Biol Rep. 2012;39:4589-96 pubmed publisher
    b>Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health...
  49. Kwolek Mirek M, Zadrag Tecza R, Bednarska S, Bartosz G. Yeast Saccharomyces cerevisiae devoid of Cu,Zn-superoxide dismutase as a cellular model to study acrylamide toxicity. Toxicol In Vitro. 2011;25:573-9 pubmed publisher
    b>Acrylamide is known as a cytotoxic and genotoxic component of starch-containing heat-processed food...
  50. Wilson K, Mucci L, Rosner B, Willett W. A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. Cancer Epidemiol Biomarkers Prev. 2010;19:2503-15 pubmed publisher
    b>Acrylamide is a probable human carcinogen formed during cooking of many common foods...
  51. Halford N, Muttucumaru N, Powers S, Gillatt P, Hartley L, Elmore J, et al. Concentrations of free amino acids and sugars in nine potato varieties: effects of storage and relationship with acrylamide formation. J Agric Food Chem. 2012;60:12044-55 pubmed publisher
    b>Acrylamide forms during cooking and processing predominately from the reaction of free asparagine and reducing sugars in the Maillard reaction...
  52. Seale S, Feng Q, Agarwal A, El Alfy A. Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. Pharmacol Biochem Behav. 2012;101:77-84 pubmed publisher
    b>Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. While the primary source of human exposure to acrylamide is occupational, other exposure sources include food, drinking water, and smoking...
  53. Xichun Z. Long-term exposure to various types of dietary fat modulates acrylamide-induced preneoplastic lesions of colon mucosa through Wnt/beta-catenin signaling in rats. Toxicol Mech Methods. 2009;19:285-91 pubmed publisher
    ..whether various dietary fats affected the Wnt signaling pathway of preneoplastic lesions of colon mucosa in acrylamide (ACR)-treated rats...