acrylamides

Summary

Summary: Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.

Top Publications

  1. Chou F, Lai J, Shih C, Tsai M, Lue S. In vitro biocompatibility of magnetic thermo-responsive nanohydrogel particles of poly(N-isopropylacrylamide-co-acrylic acid) with Fe3O4 cores: effect of particle size and chemical composition. Colloids Surf B Biointerfaces. 2013;104:66-74 pubmed publisher
    ..Overall, the in vitro biocompatibilities of the nanoparticles depend on the chemical composition and size of the Fe(3)O(4)/P(NIPAAm-co-AAc) particles...
  2. Pelin M, Ponti C, Sosa S, Gibellini D, Florio C, Tubaro A. Oxidative stress induced by palytoxin in human keratinocytes is mediated by a H+-dependent mitochondrial pathway. Toxicol Appl Pharmacol. 2013;266:1-8 pubmed publisher
  3. Thakur B, Dittrich T, Chandra P, Becker A, Lippka Y, Selvakumar D, et al. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochem Biophys Res Commun. 2012;424:371-7 pubmed publisher
  4. Green N, Hale A, Cawood R, Illingworth S, Herbert C, Hermiston T, et al. Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer. Nanomedicine (Lond). 2012;7:1683-95 pubmed publisher
  5. Pfannkuchen M, Godrijan J, Pfannkuchen D, Ivesa L, Kružić P, Ciminiello P, et al. Toxin-producing Ostreopsis cf. ovata are likely to bloom undetected along coastal areas. Environ Sci Technol. 2012;46:5574-82 pubmed publisher
    ..Increased monitoring efforts are therefore required to understand the ecology and toxicology of those bloom events and reduce their negative impact on coastal populations...
  6. Esposito E, Impellizzeri D, Mazzon E, Fakhfouri G, Rahimian R, Travelli C, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012;9:66 pubmed publisher
    ..Given the role of inflammatory responses in spinal cord injury (SCI), the effect of NAMPT inhibitors was examined in this setting...
  7. Yang J, Song B, Bhadury P, Chen Z, Yang S, Cai X, et al. Synthesis and antiviral bioactivities of 2-cyano-3-substituted-amino(phenyl) methylphosphonylacrylates (acrylamides) containing alkoxyethyl moieties. J Agric Food Chem. 2010;58:2730-5 pubmed publisher
    ..developed for the synthesis of a series of novel 2-cyano-3-substituted-amino(phenyl) methylphosphonylacrylates (acrylamides) II...
  8. Franchini A, Casarini L, Malagoli D, Ottaviani E. Expression of the genes siamois, engrailed-2, bmp4 and myf5 during Xenopus development in presence of the marine toxins okadaic acid and palytoxin. Chemosphere. 2009;77:308-12 pubmed publisher
    ..The results show that PTX induces an increase in expression levels in all tested genes, while the response to OA seems to be more stage-dependent, with the embryonic development stage more sensitive to the toxin than the larval stages...
  9. Ares I, Cagide E, Louzao M, Espiña B, Vieytes M, Yasumoto T, et al. Ostreocin-D impact on globular actin of intact cells. Chem Res Toxicol. 2009;22:374-81 pubmed publisher
    ..The data suggest that ostreocin-D modulates the unassembled actin pool, activating signal transduction pathways not related to Ca2+ influx in the same way as palytoxin...

Scientific Experts

More Information

Publications62

  1. Ulbrich K, Subr V. Structural and chemical aspects of HPMA copolymers as drug carriers. Adv Drug Deliv Rev. 2010;62:150-66 pubmed publisher
  2. Sala G, Bellocci M, Rossini G. The cytotoxic pathway triggered by palytoxin involves a change in the cellular pool of stress response proteins. Chem Res Toxicol. 2009;22:2009-16 pubmed publisher
  3. Cui Z, Lee B, Pauken C, Vernon B. Degradation, cytotoxicity, and biocompatibility of NIPAAm-based thermosensitive, injectable, and bioresorbable polymer hydrogels. J Biomed Mater Res A. 2011;98:159-66 pubmed publisher
    ..2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011...
  4. Dan L, Klimenkova O, Klimiankou M, Klusman J, van den Heuvel Eibrink M, Reinhardt D, et al. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica. 2012;97:551-9 pubmed publisher
    ..Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear...
  5. Ciminiello P, Dell Aversano C, Fattorusso E, Forino M, Tartaglione L, Grillo C, et al. Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak. J Am Soc Mass Spectrom. 2008;19:111-20 pubmed
    ..We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself...
  6. Green N, Morrison J, Hale S, Briggs S, Stevenson M, Subr V, et al. Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer. J Gene Med. 2008;10:280-9 pubmed publisher
  7. Espiña B, Cagide E, Louzao M, Fernandez M, Vieytes M, Katikou P, et al. Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells. Biosci Rep. 2009;29:13-23 pubmed publisher
  8. Rodrigues A, Almeida A, Infantosi A. Effect of palytoxin on the sodium-potassium pump: model and simulation. Phys Biol. 2008;5:036005 pubmed publisher
  9. Olesen U, Thougaard A, Jensen P, Sehested M. A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor. Mol Cancer Ther. 2010;9:1609-17 pubmed publisher
    ..In conclusion, the combination of high doses of APO866 with rescue by nicotinic acid may significantly increase the therapeutic potential in a subset of cancers with low expression of nicotinic acid phosphoribosyltransferase...
  10. Ciminiello P, Dell Aversano C, Dello Iacovo E, Fattorusso E, Forino M, Grauso L, et al. High resolution LC-MS(n) fragmentation pattern of palytoxin as template to gain new insights into ovatoxin-a structure. The key role of calcium in MS behavior of palytoxins. J Am Soc Mass Spectrom. 2012;23:952-63 pubmed publisher
    ..Either the regions or the specific sites where ovatoxin-a and palytoxin structurally differ have been identified...
  11. Fitzpatrick S, Jafar Mazumder M, Lasowski F, Fitzpatrick L, Sheardown H. PNIPAAm-grafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules. 2010;11:2261-7 pubmed publisher
    ..These results indicate the potential of using PNIPAAm-grafted-collagen as a vehicle for the delivery of therapeutic cells to the subretinal space...
  12. Hara Y, Yoshida R. Self-oscillating polymer fueled by organic acid. J Phys Chem B. 2008;112:8427-9 pubmed publisher
    ..By using the polymer, we first succeeded in causing the self-oscillation of the polymer only in the coexistence of organic acid...
  13. Zoppoli G, Cea M, Soncini D, Fruscione F, Rudner J, Moran E, et al. Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. Exp Hematol. 2010;38:979-88 pubmed publisher
    ..Here we have explored the interaction between APO866 and TRAIL in leukemia cell lines and in primary B-cell chronic lymphocytic leukemia cells...
  14. Wattenberg E. Modulation of protein kinase signaling cascades by palytoxin. Toxicon. 2011;57:440-8 pubmed publisher
    ..The studies discussed in this review investigated how palytoxin stimulates MAP kinase activity and, in turn, how MAP kinases mediate the response of cells to palytoxin...
  15. Tubaro A, Durando P, Del Favero G, Ansaldi F, Icardi G, Deeds J, et al. Case definitions for human poisonings postulated to palytoxins exposure. Toxicon. 2011;57:478-95 pubmed publisher
    ..A standardized protocol for data collection could provide a more rapid and reliable diagnosis of palytoxin-poisoning, but also the collection of necessary data for the risk assessment for this family of toxins...
  16. Honsell G, De Bortoli M, Boscolo S, Dell Aversano C, Battocchi C, Fontanive G, et al. Harmful dinoflagellate Ostreopsis cf. ovata Fukuyo: detection of ovatoxins in field samples and cell immunolocalization using antipalytoxin antibodies. Environ Sci Technol. 2011;45:7051-9 pubmed publisher
  17. Cea M, Soncini D, Fruscione F, Raffaghello L, Garuti A, Emionite L, et al. Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS ONE. 2011;6:e22739 pubmed publisher
    ..In conclusion, NAD(+)-independent HDACs and sirtuins cooperate in leukemia cells to avoid apoptosis. Combining sirtuin with HDAC inhibitors results in synergistic antileukemic activity that could be therapeutically exploited...
  18. Wu C. Palytoxin: membrane mechanisms of action. Toxicon. 2009;54:1183-9 pubmed publisher
    ..As a result palytoxin causes a wide spectrum of secondary pharmacological actions. By acting like a key to unlock the internal structure of the Na,K-ATPase, palytoxin holds promise as a useful tool for investigation of the pump molecule...
  19. Munday R. Palytoxin toxicology: animal studies. Toxicon. 2011;57:470-7 pubmed publisher
    ..Information required for the risk assessment of palytoxin and its derivatives is by no means complete, and recommendations for further studies, which may better inform regulatory decisions regarding these substances, are also discussed...
  20. Pelin M, Sosa S, Della Loggia R, Poli M, Tubaro A, Decorti G, et al. The cytotoxic effect of palytoxin on Caco-2 cells hinders their use for in vitro absorption studies. Food Chem Toxicol. 2012;50:206-11 pubmed publisher
    ..These results indicate that, due to the high susceptibility to PLTX cytotoxic effects, Caco-2 cells do not represent an appropriate and reliable model for investigating intestinal barrier permeation by this toxin...
  21. Fredolini C, Tamburro D, Gambara G, Lepene B, Espina V, Petricoin E, et al. Nanoparticle technology: amplifying the effective sensitivity of biomarker detection to create a urine test for hGH. Drug Test Anal. 2009;1:447-54 pubmed publisher
    ..This technology now provides an opportunity to evaluate the concentration of hGH in urine with high precision and accuracy...
  22. Pezzolesi L, Guerrini F, Ciminiello P, Dell Aversano C, Dello Iacovo E, Fattorusso E, et al. Influence of temperature and salinity on Ostreopsis cf. ovata growth and evaluation of toxin content through HR LC-MS and biological assays. Water Res. 2012;46:82-92 pubmed publisher
  23. Ledreux A, Krys S, Bernard C. Suitability of the Neuro-2a cell line for the detection of palytoxin and analogues (neurotoxic phycotoxins). Toxicon. 2009;53:300-8 pubmed publisher
    ..We conclude by proposing an experimental design for functional assays using the Neuro-2a cell line for the specific detection of four neurotoxic phycotoxin families: saxitoxins, brevetoxins, ciguatoxins and palytoxins...
  24. Ciminiello P, Dell Aversano C, Dello Iacovo E, Fattorusso E, Forino M, Grauso L, et al. Stereostructure and biological activity of 42-hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies. Chem Res Toxicol. 2009;22:1851-9 pubmed publisher
    ..toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities...
  25. Herth M, Barz M, Moderegger D, Allmeroth M, Jahn M, Thews O, et al. Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography. Biomacromolecules. 2009;10:1697-703 pubmed publisher
    ..Furthermore, low metabolism rates could be detected in urine as well as in the blood. Thus, we expect this new strategy for radioactive labeling of polymers as a promising approach for in vivo PET studies...
  26. Galli U, Ercolano E, Carraro L, Blasi Roman C, Sorba G, Canonico P, et al. Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem. 2008;3:771-9 pubmed publisher
    ..Here we report the synthesis of analogues of FK866 synthesized by click chemistry...
  27. Taaning R, Lindsay K, Schiøtt B, Daasbjerg K, Skrydstrup T. Importance of C-N bond rotation in N-acyl oxazolidinones in their SmI2-promoted coupling to acrylamides. J Am Chem Soc. 2009;131:10253-62 pubmed publisher
    ..transfer steps in the SmI(2)-promoted carbon-carbon bond forming reaction between N-acyl oxazolidinones and acrylamides. Competition experiments were performed by reacting two N-acyl oxazolidinones with a limiting amount of N-t-..
  28. Riobo P, Paz B, Franco J, Vazquez J, Murado M, Cacho E. Mouse bioassay for palytoxin. Specific symptoms and dose-response against dose-death time relationships. Food Chem Toxicol. 2008;46:2639-47 pubmed publisher
    ..Herein is demonstrated that the logistic equation and the accumulative function of Weibull's distribution (with the modifications proposed) generate satisfactory toxicological descriptions in all the respects...
  29. Yasuda K, Kitamura N, Gong J, Arakaki K, Kwon H, Onodera S, et al. A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect. Macromol Biosci. 2009;9:307-16 pubmed publisher
    ..This study prompted an innovative strategy in the field of joint surgery to repair an osteochondral defect using an advanced, high-function hydrogel...
  30. Nagase K, Kobayashi J, Okano T. Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering. J R Soc Interface. 2009;6 Suppl 3:S293-309 pubmed publisher
  31. Sosa S, Del Favero G, De Bortoli M, Vita F, Soranzo M, Beltramo D, et al. Palytoxin toxicity after acute oral administration in mice. Toxicol Lett. 2009;191:253-9 pubmed publisher
    ..A NOEL of 300 microg/kg can be estimated from this acute oral toxicity study...
  32. Dai W, Zhang Y, Du Z, Ru M, Lang M. The pH-induced thermosensitive poly (NIPAAm-co-AAc-co-HEMA)-g-PCL micelles used as a drug carrier. J Mater Sci Mater Med. 2010;21:1881-90 pubmed publisher
    ..The release of DOX from micelles could be controlled by changing pH value and temperature in buffer solutions. The micelles are potentially to be used as a new anticancer drug carrier for intracellular delivery...
  33. Rossi R, Castellano V, Scalco E, Serpe L, Zingone A, Soprano V. New palytoxin-like molecules in Mediterranean Ostreopsis cf. ovata (dinoflagellates) and in Palythoa tuberculosa detected by liquid chromatography-electrospray ionization time-of-flight mass spectrometry. Toxicon. 2010;56:1381-7 pubmed publisher
    ..cf. ovata. Another new palytoxin was detected in the standard material from Palythoa tuberculosa provided by Wako Chemicals...
  34. Cabaleiro Lago C, Lynch I, Dawson K, Linse S. Inhibition of IAPP and IAPP(20-29) fibrillation by polymeric nanoparticles. Langmuir. 2010;26:3453-61 pubmed publisher
    ..For the fragment (IAPP(20-29)), the presence of nanoparticles changes the mechanism of association from monomers to fibrils, by interfering with early oligomeric species along the fibrillation pathway...
  35. De Deene Y, Pittomvils G, Visalatchi S. The influence of cooling rate on the accuracy of normoxic polymer gel dosimeters. Phys Med Biol. 2007;52:2719-28 pubmed
    ..A reproducibility study has also been performed on the nPAG gel dosimeter when additional efforts are made to control the temperature changes upon cooling...
  36. Wang D. Neurotoxins from marine dinoflagellates: a brief review. Mar Drugs. 2008;6:349-71 pubmed publisher
    ..This review summarizes the origin, structure and clinical symptoms of PSP, NSP, CFP, AZP, yessotoxin and palytoxin produced by marine dinoflagellates, as well as their molecular mechanisms of action on voltage-gated ion channels...
  37. Olesen U, Christensen M, Bjorkling F, Jaattela M, Jensen P, Sehested M, et al. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008;367:799-804 pubmed publisher
    ..Finally, we observed that treatment with CHS-828 depletes cellular NAD levels in sensitive cancer cells. In conclusion, these results strongly suggest that, like FK866, CHS-828 kills cancer cells by depleting NAD...
  38. Deeds J, Schwartz M. Human risk associated with palytoxin exposure. Toxicon. 2010;56:150-62 pubmed publisher
    ..Continued research into the distribution and occurrence of PTX and PTX-like compounds both in seafood and marine organisms sold in the aquarium trade appears warranted...
  39. Moran M, Carroll W, Selezneva I, Gorelov A, Rochev Y. Cell growth and detachment from protein-coated PNIPAAm-based copolymers. J Biomed Mater Res A. 2007;81:870-6 pubmed
    ..The results demonstrate a versatile method for the cultivation of cells while eliminating the need for the use of digestive enzymes such as trypsin...
  40. Seymour L, Ferry D, Kerr D, Rea D, Whitlock M, Poyner R, et al. Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol. 2009;34:1629-36 pubmed
  41. Fundueanu G, Constantin M, Oanea I, Harabagiu V, Ascenzi P, Simionescu B. Prediction of the appropriate size of drug molecules that could be released by a pulsatile mechanism from pH/thermoresponsive microspheres obtained from preformed polymers. Acta Biomater. 2012;8:1281-9 pubmed publisher
  42. Ramos V, Vasconcelos V. Palytoxin and analogs: biological and ecological effects. Mar Drugs. 2010;8:2021-37 pubmed publisher
    ..In this paper, we review the current knowledge on the effects of PTX and its analogs on different organisms, exposing the impact that these toxins may have in coastal ecosystems...
  43. Zhang L, Liu L, Qie L, Ling K, Xu L, Wang F, et al. Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase. Eur J Pharmacol. 2012;674:163-70 pubmed publisher
    ..Taken together, our results indicated that APO866 is a potent growth inhibitor against glioblastoma through targeting NAMPT...
  44. Vale Gonzalez C, Pazos M, Alfonso A, Vieytes M, Botana L. Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor. Toxicon. 2007;50:541-52 pubmed
  45. Tanabe Y, Yasuda K, Azuma C, Taniguro H, Onodera S, Suzuki A, et al. Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues. J Mater Sci Mater Med. 2008;19:1379-87 pubmed
    ..The PAMPS/polyacrylamide and Cellulose/PDMAAm gels induced a significant inflammation at each week. These DN gels are difficult to be applied as clinical implants in the current situation...
  46. Aligizaki K, Katikou P, Milandri A, Diogène J. Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art. Toxicon. 2011;57:390-9 pubmed publisher
    ..Future recommendations include systematic screening of PlTX in those species and areas where PlTX has already been recorded implementing updated methodologies...
  47. Charlson A, Zeliadt N, Wattenberg E. Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin. Toxicol Appl Pharmacol. 2009;241:143-53 pubmed publisher
    ..These results suggest that ERK5 can act as an alternative mediator for transmitting diverse tumor promoter-stimulated signals...
  48. Ciminiello P, Dell Aversano C, Dello Iacovo E, Fattorusso E, Forino M, Tartaglione L, et al. Palytoxin in seafood by liquid chromatography tandem mass spectrometry: investigation of extraction efficiency and matrix effect. Anal Bioanal Chem. 2011;401:1043-50 pubmed publisher
  49. Kerbrat A, Amzil Z, Pawlowiez R, Golubic S, Sibat M, Darius H, et al. First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium. Mar Drugs. 2011;9:543-60 pubmed publisher
    ..The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed...
  50. Pelin M, Zanette C, De Bortoli M, Sosa S, Loggia R, Tubaro A, et al. Effects of the marine toxin palytoxin on human skin keratinocytes: role of ionic imbalance. Toxicology. 2011;282:30-8 pubmed publisher
    ..The PLTX concentrations inducing cytotoxicty seem to be lower than those of potential cutaneous human exposure during Ostreopsis ovata blooms, indicating the harmful potential of the toxin...
  51. Pistocchi R, Pezzolesi L, Guerrini F, Vanucci S, Dell Aversano C, Fattorusso E. A review on the effects of environmental conditions on growth and toxin production of Ostreopsis ovata. Toxicon. 2011;57:421-8 pubmed publisher
    ..e. 40). For the same strain, both nitrogen and phosphorus limitation determined a decrease in cell toxicity showing different behaviour with respect to many other toxic dinoflagellates...
  52. Roepke T, Bosch M, Rick E, Lee B, Wagner E, Seidlova Wuttke D, et al. Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology. 2010;151:4926-37 pubmed publisher
    ..Therefore, a Gq-mER-coupled signaling pathway appears to be involved in maintaining homeostatic functions and may constitute a novel therapeutic target for treatment of hypoestrogenic symptoms...
  53. Garbern J, Hoffman A, Stayton P. Injectable pH- and temperature-responsive poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors. Biomacromolecules. 2010;11:1833-9 pubmed publisher
    ..This hydrogel system will thus gel at controllable acidic pH values upon injection, and is designed to undergo gradual dissolution as it performs its drug delivery function and the ischemic site returns to physiological pH...