carboxylic acids


Summary: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Top Publications

  1. Paiva S, Strachotov D, Ku erov H, Hlav ek O, Mota S, Casal M, et al. The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies. Biochem J. 2013;454:551-8 pubmed publisher
    ..Both lactic acid uptake mechanisms are diminished in sok2 colonies where JEN1 expression is decreased. The Sok2p transcription factor may therefore be involved in the regulation of non-saturable lactic acid uptake in yeast colonies...
  2. Yang Y, Yao J, Zhang Y. Synthesis of polysubstituted furans via copper-mediated annulation of alkyl ketones with ?,?-unsaturated carboxylic acids. Org Lett. 2013;15:3206-9 pubmed publisher
    A novel copper-mediated annulation of alkyl ketones with ?,?-unsaturated carboxylic acids has been accomplished...
  3. Xia Q, Liu X, Zhang Y, Chen C, Chen W. Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents. Org Lett. 2013;15:3326-9 pubmed publisher
    The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters...
  4. Whelan R, Levin T, Owen J, Garvin M. Short-chain carboxylic acids from gray catbird (Dumetella carolinensis) uropygial secretions vary with testosterone levels and photoperiod. Comp Biochem Physiol B Biochem Mol Biol. 2010;156:183-8 pubmed publisher
    ..We consistently detected the following carboxylic acids: acetic, propanoic, 2-methylpropanoic, butanoic, and 3-methylbutanoic...
  5. Can Güven S, Laska M. Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice. PLoS ONE. 2012;7:e34301 pubmed publisher
    Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated...
  6. Xiang Y, Hirth B, Asmussen G, Biemann H, Bishop K, Good A, et al. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg Med Chem Lett. 2011;21:3050-6 pubmed publisher
    Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization...
  7. Lu P, Sanchez C, Cornella J, Larrosa I. Silver-catalyzed protodecarboxylation of heteroaromatic carboxylic acids. Org Lett. 2009;11:5710-3 pubmed publisher
    A simple and highly efficient protodecarboxylation procedure for a variety of heteroaromatic carboxylic acids catalyzed by Ag(2)CO(3) and AcOH in DMSO is described...
  8. Vazquez J, Durán A, Rodríguez Amado I, Prieto M, Rial D, Murado M. Evaluation of toxic effects of several carboxylic acids on bacterial growth by toxicodynamic modelling. Microb Cell Fact. 2011;10:100 pubmed publisher
    ..However, they typically provide only descriptive information without modelling the influence of acid concentrations on bacterial kinetics...
  9. Nagy P, Erhardt P. On the interaction of aliphatic amines and ammonium ions with carboxylic acids in solution and in receptor pockets. J Phys Chem B. 2012;116:5425-36 pubmed publisher

More Information


  1. Abbott D, Zelle R, Pronk J, van Maris A. Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges. FEMS Yeast Res. 2009;9:1123-36 pubmed publisher
    ..In addition to recent progress in engineering S. cerevisiae for organic acid production, the key limitations and challenges are discussed in the context of sustainable industrial production of organic acids from renewable feedstocks...
  2. Fu Z, Holtzapple M. Fermentation of sugarcane bagasse and chicken manure to calcium carboxylates under thermophilic conditions. Appl Biochem Biotechnol. 2010;162:561-78 pubmed publisher
    Sugarcane bagasse and chicken manure were anaerobically fermented to carboxylic acids using a mixed culture of marine microorganisms at 55 degrees C...
  3. Smallegange R, Qiu Y, Bukovinszkiné Kiss G, van Loon J, Takken W. The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. J Chem Ecol. 2009;35:933-43 pubmed publisher
    The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps...
  4. Petersen T, Khan R, Olofsson B. Metal-free synthesis of aryl esters from carboxylic acids and diaryliodonium salts. Org Lett. 2011;13:3462-5 pubmed publisher
    An efficient arylation of carboxylic acids with diaryliodonium salts has been developed, giving aryl esters in high yields within short reaction times for both aromatic and aliphatic substrates...
  5. Lindenkamp N, Schürmann M, Steinbüchel A. A propionate CoA-transferase of Ralstonia eutropha H16 with broad substrate specificity catalyzing the CoA thioester formation of various carboxylic acids. Appl Microbiol Biotechnol. 2013;97:7699-709 pubmed publisher
    ..spectrometry (HPLC/MS) analyses revealed that the enzyme exhibits a broad substrate specificity for carboxylic acids. The formation of the corresponding CoA-thioesters of acetate using propionyl-CoA as CoA donor, and of ..
  6. Ho Y, Huang Y, Huang C. Chemical rescue of the post-translationally carboxylated lysine mutant of allantoinase and dihydroorotase by metal ions and short-chain carboxylic acids. Amino Acids. 2013;44:1181-91 pubmed publisher
    ..of the K146A mutant of the ALLase and the K103A mutant of DHOase can be chemically rescued by short-chain carboxylic acids, such as acetic, propionic, and butyric acids, but not by ethanol, propan-1-ol, and imidazole, in the ..
  7. Chen P, Horton L, Mikulski R, Deng L, Sundriyal S, Palzkill T, et al. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-?-lactamases. Bioorg Med Chem Lett. 2012;22:6229-32 pubmed publisher
    ..We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors...
  8. Bhadra S, Dzik W, Goossen L. Decarboxylative etherification of aromatic carboxylic acids. J Am Chem Soc. 2012;134:9938-41 pubmed publisher
    ..for the regiospecific construction of diaryl and alkyl aryl ethers starting from easily available aromatic carboxylic acids. They allow converting various aromatic carboxylate salts into the corresponding aryl ethers by reaction with ..
  9. Kumar S, Namkung W, Verkman A, Sharma P. Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem. 2012;20:4237-44 pubmed publisher
    ..Thirty novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids (B01-B30) were synthesized and evaluated for their TMEM16A inhibitory activity by using short circuit current ..
  10. Castanedo G, Seng P, Blaquiere N, Trapp S, Staben S. Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines. J Org Chem. 2011;76:1177-9 pubmed publisher
    A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines...
  11. Zhang W, Zhang X, Li J. Palladium-catalyzed decarboxylative coupling of alkynyl carboxylic acids with benzyl halides or aryl halides. J Org Chem. 2010;75:5259-64 pubmed publisher
    ..1,2-diarylalkynes has been developed via palladium-catalyzed decarboxylative coupling reactions of alkynyl carboxylic acids with benzyl chlorides or aryl halides...
  12. Gao X, Zhang F, Hoffland E. Malate exudation by six aerobic rice genotypes varying in zinc uptake efficiency. J Environ Qual. 2009;38:2315-21 pubmed publisher
    ..The results also emphasize that effects of root exudates on soil properties need to be assessed to evaluate the role of root exudation in nutrient mobilization...
  13. Chen Q, Song J, Pan F, Xia F, Yuan J. The kinetics of photocatalytic degradation of aliphatic carboxylic acids in an UV/TiO2 suspension system. Environ Technol. 2009;30:1103-9 pubmed publisher
    Kinetic studies on the photocatalytic degradation of aliphatic carboxylic acids were carried out in a slurry photoreactor with in-situ monitoring, employing artificial UV light as the source of energy and nano-TiO2 powder as the catalyst...
  14. Finkemeier I, König A, Heard W, Nunes Nesi A, Pham P, Leister D, et al. Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves. Plant Physiol. 2013;162:239-53 pubmed publisher
    ..Although some carboxylic acids have been implicated in the regulation of gene expression for select transcripts, it is unclear whether all ..
  15. Liu X, Wang Z, Cheng X, Li C. Silver-catalyzed decarboxylative alkynylation of aliphatic carboxylic acids in aqueous solution. J Am Chem Soc. 2012;134:14330-3 pubmed publisher
    ..Thus, with AgNO(3) as the catalyst and K(2)S(2)O(8) as the oxidant, various aliphatic carboxylic acids underwent decarboxylative alkynylation with commercially available ethynylbenziodoxolones in aqueous solution ..
  16. O Brien J, Crump D, Mundy L, Chu S, McLaren K, Vongphachan V, et al. Pipping success and liver mRNA expression in chicken embryos exposed in ovo to C8 and C11 perfluorinated carboxylic acids and C10 perfluorinated sulfonate. Toxicol Lett. 2009;190:134-9 pubmed publisher
    ..Based on the present results for white leghorn chickens, current environmental concentrations of PFOA, PFUdA and PFDS are unlikely to affect the hatching success of wild birds...
  17. Szostak M, Spain M, Procter D. Electron transfer reduction of carboxylic acids using SmI2-H2O-Et3N. Org Lett. 2012;14:840-3 pubmed publisher
    The first general method for efficient electron transfer reduction of carboxylic acids has been developed...
  18. Wakayama M, Aoki N, Sasaki H, Ohsugi R. Simultaneous analysis of amino acids and carboxylic acids by capillary electrophoresis-mass spectrometry using an acidic electrolyte and uncoated fused-silica capillary. Anal Chem. 2010;82:9967-76 pubmed publisher
    ..spectrometry (CE-MS) method is demonstrated for the simultaneous analysis of amino acids and small carboxylic acids (glycerate, lactate, fumarate, succinate, malate, tartrate, citrate, iso-citrate, cis-aconitate, and ..
  19. D eon J, Simpson A, Kumar R, Baer A, Mabury S. Determining the molecular interactions of perfluorinated carboxylic acids with human sera and isolated human serum albumin using nuclear magnetic resonance spectroscopy. Environ Toxicol Chem. 2010;29:1678-88 pubmed publisher
    ..Perfluorohexanoic acid (PFHxA) and PFOA were used as model perfluorinated carboxylic acids (PFCAs) to characterize the major site of PFCA interaction in human sera...
  20. Rughoonundun H, Granda C, Mohee R, Holtzapple M. Effect of thermochemical pretreatment on sewage sludge and its impact on carboxylic acids production. Waste Manag. 2010;30:1614-21 pubmed publisher
    This paper investigates the potential of converting sewage sludge into a useful product, namely carboxylic acids. To potentially enhance acid yields, the effect of pretreatment using 0...
  21. Kitanovski Z, Grgic I, Veber M. Characterization of carboxylic acids in atmospheric aerosols using hydrophilic interaction liquid chromatography tandem mass spectrometry. J Chromatogr A. 2011;1218:4417-25 pubmed publisher
    ..e. cis-pinonic and pinic acid) and aromatic (i.e. trimesic, phthalic acid and its isomers) carboxylic acids. Analytes were separated on an amide column using a gradient elution with a 10mM constant ionic strength ..
  22. Cometto Muniz J, Abraham M. Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans. Exp Brain Res. 2010;207:75-84 pubmed publisher
    ..We discuss the mechanistic implications of this model for the process of olfactory detection...
  23. Miyazawa T, Gallagher M, Preti G, Wise P. Odor detection of mixtures of homologous carboxylic acids and coffee aroma compounds by humans. J Agric Food Chem. 2009;57:9895-901 pubmed publisher
    Mixture summation among homologous carboxylic acids, that is, the relationship between detection probabilities for mixtures and detection probabilities for their unmixed components, varies with similarity in carbon-chain length...
  24. Gheibi N, Saboury A, Haghbeen K, Rajaei F, Pahlevan A. Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase. J Enzyme Inhib Med Chem. 2009;24:1076-81 pubmed publisher
    ..Thus, they could completely block the cresolase reaction, by preventing monophenol binding to the enzyme. From an allosteric point of view, n-alkyl acids may be involved in activation of MT catecholase reactions...
  25. Blum M, Boehler M, Randall E, Young V, Csukai M, Kraus S, et al. Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans. Mol Plant Pathol. 2010;11:227-43 pubmed publisher
    ..The transformation and expression of a mutated PiCesA3 allele was carried out in a sensitive wild-type isolate to demonstrate that the mutations in PiCesA3 were responsible for the MPD insensitivity phenotype...
  26. Blum M, Waldner M, Gisi U. A single point mutation in the novel PvCesA3 gene confers resistance to the carboxylic acid amide fungicide mandipropamid in Plasmopara viticola. Fungal Genet Biol. 2010;47:499-510 pubmed publisher
    ..Our data demonstrate that the identified genes are putative cellulose synthases and that one recessive mutation in PvCesA3 causes inheritable resistance to the CAA fungicide mandipropamid...
  27. Widodo B, Broadley M, Rose T, Frei M, Pariasca Tanaka J, Yoshihashi T, et al. Response to zinc deficiency of two rice lines with contrasting tolerance is determined by root growth maintenance and organic acid exudation rates, and not by zinc-transporter activity. New Phytol. 2010;186:400-14 pubmed publisher
    ..Zinc-deficiency tolerance in RIL46 is most likely the result of maintenance of root growth, increased efflux of Zn ligands, and increased uptake of Zn-ligand complexes at low [Zn](ext); these traits are potential breeding targets...
  28. Perez J, Richter H, Loftus S, Angenent L. Biocatalytic reduction of short-chain carboxylic acids into their corresponding alcohols with syngas fermentation. Biotechnol Bioeng. 2013;110:1066-77 pubmed publisher
    Short-chain carboxylic acids generated by various mixed- or pure-culture fermentation processes have been considered valuable precursors for production of bioalcohols...
  29. Yang Y, Xie C, Xie Y, Zhang Y. Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with ?,?-unsaturated carboxylic acids. Org Lett. 2012;14:957-9 pubmed publisher
    A novel copper-catalyzed annulation of 2-alkylazaarenes with ?,?-unsaturated carboxylic acids has been accomplished...
  30. Natsch A, Kuhn F, Tiercy J. Lack of evidence for HLA-linked patterns of odorous carboxylic acids released from glutamine conjugates secreted in the human axilla. J Chem Ecol. 2010;36:837-46 pubmed publisher
    ..Volatile carboxylic acids are the most diverse class of known axillary odorants, and the pattern of these acids is genetically ..
  31. Skinner P, Webb P, Sage C, Dang T, Pride C, Chen R, et al. 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett. 2009;19:4207-9 pubmed publisher
    A series of 5-N,N-disubstituted-5-aminopyrazole-3-carboxylic acids were prepared and found to act as highly potent and selective agonists of the G-Protein Coupled Receptor (GPCR) GPR109b, a low affinity receptor for niacin and some ..
  32. Chao C, Wu Y, Wen Z, Sheu J. Steroidal carboxylic acids from soft coral Paraminabea acronocephala. Mar Drugs. 2013;11:136-45 pubmed publisher
    Three new steroidal carboxylic acids, paraminabic acids A-C (1-3) were isolated from a Formosan soft coral Paraminabea acronocephala...
  33. Hu P, Kan J, Su W, Hong M. Pd(O2CCF3)2/benzoquinone: a versatile catalyst system for the decarboxylative olefination of arene carboxylic acids. Org Lett. 2009;11:2341-4 pubmed publisher
  34. Aoki Y, Furuya S, Suzuki S. Method for rapid detection of the PvCesA3 gene allele conferring resistance to mandipropamid, a carboxylic acid amide fungicide, in Plasmopara viticola populations. Pest Manag Sci. 2011;67:1557-61 pubmed publisher
    ..The occurrence of carboxylic acid amide (CAA)-fungicide-resistant Plasmopara viticola populations is becoming a serious problem in the control of grapevine downy mildew worldwide...
  35. Fernández Álvaro E, Kourist R, Winter J, Böttcher D, Liebeton K, Naumer C, et al. Enantioselective kinetic resolution of phenylalkyl carboxylic acids using metagenome-derived esterases. Microb Biotechnol. 2010;3:59-64 pubmed publisher
    Enantiomerically pure ?-arylalkyl carboxylic acids are important synthetic intermediates for the preparation of a wide range of compounds with biological and pharmacological activities...
  36. Guruge K, Yeung L, Li P, Taniyasu S, Yamashita N, Nakamura M. Fluorinated alkyl compounds including long chain carboxylic acids in wild bird livers from Japan. Chemosphere. 2011;83:379-84 pubmed publisher a Japanese sparrowhawk, indicating that the top predatory wild birds can accumulate several long chain carboxylic acids. However, the current FAC concentrations found in livers may suggest that these compounds alone would not ..
  37. Ruan T, Wang Y, Wang T, Zhang Q, Ding L, Liu J, et al. Presence and partitioning behavior of polyfluorinated iodine alkanes in environmental matrices around a fluorochemical manufacturing plant: another possible source for perfluorinated carboxylic acids?. Environ Sci Technol. 2010;44:5755-61 pubmed publisher
  38. Abou Elseoud S, Abdel Fattah N, Ezz El Din H, Abdel Al H, Mossalem H, Elleboudy N. Carboxylic acids as biomarkers of Biomphalaria alexandrina snails infected with Schistosoma mansoni. Korean J Parasitol. 2010;48:127-32 pubmed publisher
    ..Quantification of carboxylic acids, using HPLC strategy, was fast, easy, and accurate in prediction of infected and uninfected snails and ..
  39. Gernigon N, Al Zoubi R, Hall D. Direct amidation of carboxylic acids catalyzed by ortho-iodo arylboronic acids: catalyst optimization, scope, and preliminary mechanistic study supporting a peculiar halogen acceleration effect. J Org Chem. 2012;77:8386-400 pubmed publisher
    ..and synthetic products motivates the development of catalytic, direct amidation methods employing free carboxylic acids and amines that circumvent the need for stoichiometric activation or coupling reagents...
  40. Chowdhury G, Calcutt M, Guengerich F. Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps. J Biol Chem. 2010;285:8031-44 pubmed publisher
    ..parameters measured for oxidation of DMN and DEN to the aldehydes and for oxidation of the aldehydes to the carboxylic acids. Spectral analysis did not indicate strong affinity of the aldehydes for P450 2A6, but pulse-chase ..
  41. Abdel Azeem A, Abdel Hafez A, El Karamany G, Farag H. Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies. Bioorg Med Chem. 2009;17:3665-70 pubmed publisher
    ..In addition, docking of the mutual ester prodrugs (6-8) into COX-2 active site was conducted in order to predict the affinity and orientation of these prodrugs at the enzyme active site...
  42. Sato M, Kawakami H, Motomura T, Aramaki H, Matsuda T, Yamashita M, et al. Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem. 2009;52:4869-82 pubmed publisher
    ..Here, we show the synthesis and the detailed structure-activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors...
  43. Cornella J, Edwards J, Qin T, Kawamura S, Wang J, Pan C, et al. Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters. J Am Chem Soc. 2016;138:2174-7 pubmed publisher
    A new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-catalysis...
  44. Rousova J, Chintapalli M, Lindahl A, Casey J, Kubatova A. Simultaneous determination of trace concentrations of aldehydes and carboxylic acids in particulate matter. J Chromatogr A. 2018;1544:49-61 pubmed publisher
    b>Carboxylic acids and aldehydes are present in ambient air particulate matter (PM) originating from both primary emission and secondary production in air and may, due to their polarity have, an impact on formation of cloud condensation ..
  45. Li Y, Harir M, Lucio M, Gonsior M, Koch B, Schmitt Kopplin P, et al. Comprehensive structure-selective characterization of dissolved organic matter by reducing molecular complexity and increasing analytical dimensions. Water Res. 2016;106:477-487 pubmed publisher
    ..A minor early eluting hydrophilic fraction was highly aliphatic and presented a large diversity of alicyclic carboxylic acids, whereas the two late eluting, minor hydrophobic fractions appeared as a largely defunctionalized mixture of ..
  46. Kraiem T, Hassen A, Belayouni H, Jeguirim M. Production and characterization of bio-oil from the pyrolysis of waste frying oil. Environ Sci Pollut Res Int. 2017;24:9951-9961 pubmed publisher
    ..chemical mixture of linear saturated, unsaturated, and cyclic hydrocarbons and oxygenated compounds such as carboxylic acids, ketones, aldehydes, and alcohols...
  47. Curtin V, Amharar Y, Gallagher K, Corcoran S, Tajber L, Corrigan O, et al. Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids. Int J Pharm. 2013;456:508-16 pubmed publisher
    ..The results indicate that co-processing with low Tg excipients is an effective strategy at minimising amorphisation of an API on mechanical activation. ..
  48. Wagh A, Law B. Methods for conjugating antibodies to nanocarriers. Methods Mol Biol. 2013;1045:249-66 pubmed publisher
    ..The advantages and limitations are described herein. Specific examples are selected to demonstrate the experimental procedures and to illustrate the potential for applying to other nanocarrier system. ..
  49. Tang J, Goossen L. Arylalkene synthesis via decarboxylative cross-coupling of alkenyl halides. Org Lett. 2014;16:2664-7 pubmed publisher
    ..It allows the regiospecific synthesis of a broad range of aryl- and heteroarylalkenes in high yields. ..
  50. Schwartz T, Shanks B, Dumesic J. Coupling chemical and biological catalysis: a flexible paradigm for producing biobased chemicals. Curr Opin Biotechnol. 2016;38:54-62 pubmed publisher
    ..We show that carboxylic acids, pyrones, and alcohols are highly flexible platforms that can be used to produce biobased chemicals by this ..
  51. Gaida S, Al Hinai M, Indurthi D, Nicolaou S, Papoutsakis E. Synthetic tolerance: three noncoding small RNAs, DsrA, ArcZ and RprA, acting supra-additively against acid stress. Nucleic Acids Res. 2013;41:8726-37 pubmed publisher
    ..Unlike the overexpression of proteins, overexpression of sRNAs imposes hardly any metabolic burden on cells, and constitutes a more effective strain engineering strategy. ..
  52. Gremmel C, Frömel T, Knepper T. Systematic determination of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in outdoor jackets. Chemosphere. 2016;160:173-80 pubmed publisher
    ..02-171 ?g/m(2)), although at lower concentrations compared to the precursors of perfluoroalkyl carboxylic acids (PFCAs), namely fluorotelomer alcohols (FTOHs) (<0.001-698 ?g/m(2))...
  53. Juliá Hernández F, Gaydou M, Serrano E, van Gemmeren M, Martin R. Ni- and Fe-catalyzed Carboxylation of Unsaturated Hydrocarbons with CO2. Top Curr Chem (Cham). 2016;374:45 pubmed publisher
    ..Among the different alternatives in CO2 fixation, the preparation of carboxylic acids, relevant motifs in pharmaceuticals and agrochemicals, is particularly appealing, thus providing a rapid and ..
  54. Wang N, Chelme Ayala P, Pérez Estrada L, Garcia Garcia E, Pun J, Martin J, et al. Impact of ozonation on naphthenic acids speciation and toxicity of oil sands process-affected water to Vibrio fischeri and mammalian immune system. Environ Sci Technol. 2013;47:6518-26 pubmed publisher
    ..Complete removal of toxicity toward Vibrio fischeri was achieved after ozonation followed by 28-day biodegradation period. In vitro and in vivo assays indicated that ozonation reduced the OSPW toxicity to mice...
  55. Bartlett A, Frank R, Gillis P, Parrott J, Marentette J, Brown L, et al. Toxicity of naphthenic acids to invertebrates: Extracts from oil sands process-affected water versus commercial mixtures. Environ Pollut. 2017;227:271-279 pubmed publisher
    ..Our results support the need to better characterize the complex mixtures associated with bitumen-influenced waters, both chemically and toxicologically. ..
  56. Kosman J, Stanislawska A, Gluszynska A, Juskowiak B. Conjugation of hemin to G-quadruplex forming oligonucleotide using click chemistry. Int J Biol Macromol. 2017;101:799-804 pubmed publisher
    ..Using Cu-free click reaction, we successfully synthesized G-quadruplex-hemin conjugate that exhibited promising peroxidase activity. ..
  57. Zhang C, Yan H, Li F, Hu X, Zhou Q. Sorption of short- and long-chain perfluoroalkyl surfactants on sewage sludges. J Hazard Mater. 2013;260:689-99 pubmed publisher
    ..The perfluorinated sulfonic acid (PFSA) demonstrated substantially stronger sorption than perfluorinated carboxylic acid (PFCA) analog. Evidence for both hydrophobic and electrostatic interactions was found. ..
  58. Zhao T, Kurpiewska K, Kalinowska Tłuścik J, Herdtweck E, Dömling A. α-Amino Acid-Isosteric α-Amino Tetrazoles. Chemistry. 2016;22:3009-18 pubmed publisher
    ..Surprisingly, several of the common α-amino acid-isosteric α-amino tetrazoles are unknown up to now. Therefore a rapid synthetic access to this compound class and non-natural derivatives is of high interest to advance the field. ..
  59. Hata K, He Z, Daniliuc C, Itami K, Studer A. Synthesis of dihydrobenzo[b]furans by diastereoselective acyloxyarylation. Chem Commun (Camb). 2014;50:463-5 pubmed publisher
    ..synthesis of 2-aryl-3-acyloxy-2,3-dihydrobenzofurans by palladium-catalyzed acyloxyarylation involving dearomatization of benzofurans with arylboronic acids and carboxylic acids occurring under mild conditions has been developed.
  60. Wang H, Guo L, Duan X. Copper-catalyzed oxidative condensation of ?-oxocarboxylic acids with formamides: synthesis of ?-ketoamides. Org Biomol Chem. 2013;11:4573-6 pubmed publisher
    ..Mechanistic studies have shown that the reaction proceeded via a radical process and (13)C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF. ..
  61. Morgunov I, Kamzolova S, Dedyukhina E, Chistyakova T, Lunina J, Mironov A, et al. Application of organic acids for plant protection against phytopathogens. Appl Microbiol Biotechnol. 2017;101:921-932 pubmed publisher
    ..It was shown that application of carboxylic acids resulted in acceleration of plant development and the yield increase...
  62. Ong L, Tan Y, Tan B, Chung F, Cheong S, Leong C. Single-walled carbon nanotubes (SWCNTs) inhibit heat shock protein 90 (HSP90) signaling in human lung fibroblasts and keratinocytes. Toxicol Appl Pharmacol. 2017;329:347-357 pubmed publisher
    ..In summary, our findings suggest that the toxic effects of SWCNTs are mediated through inhibition of HSP90 in human lung fibroblasts and keratinocytes. ..
  63. Qin M, Tian Y, Sun X, Yu S, Xia J, Gong P, et al. Novel methyl indolinone-6-carboxylates containing an indole moiety as angiokinase inhibitors. Eur J Med Chem. 2017;139:492-502 pubmed publisher
    ..In addition, A8 effectively suppressed the proliferation of human umbilical vein endothelial cells, and HT-29 and MCF-7 cancer cells, by inducing apoptosis. Compound A8 is thus a promising candidate for further investigation. ..
  64. Kazancıoğlu E, Kazancioglu M, Fistikci M, Secen H, Altundas R. Photooxygenation of azidoalkyl furans: catalyst-free triazole and new endoperoxide rearrangement. Org Lett. 2013;15:4790-3 pubmed publisher
    ..The reduction of the peroxide bond and two subsequent C-C bond cleavages provide a triazole having a newly formed carboxylic acid functionality. The reactions are clean and efficient with yields ranging from 60% to 90%. ..